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https://www.readbyqxmd.com/read/28422594/intentional-replantation-of-an-immature-incisor-with-a-transverse-root-fracture-and-endo-perio-condition-4-year-follow-up
#1
Atsushi Oishi
This case report describes the importance of continual examination for dental trauma and the efficacy of intentional replantation with retrograde root canal filling for a transverse root fracture in an immature incisor accompanied by subsequent periodontal-endodontic disease. In the treatment of traumatically fractured roots in immature incisors, continual examination is indispensable for the final diagnosis because roots in immature teeth are less calcified, resulting in less detailed radiological examinations...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28416306/histologic-findings-of-a-human-immature-revascularized-regenerated-tooth-with-symptomatic-irreversible-pulpitis
#2
Chufang Peng, Yuming Zhao, Wenjun Wang, Yuan Yang, Man Qin, Lihong Ge
INTRODUCTION: Pulp revascularization/regeneration in immature permanent teeth with necrotic pulp and/or apical periodontitis is an effective approach for inducing root maturation. Previous histologic studies showed cementoid/osteoid tissue and/or periodontal ligament-like tissue formed within the root canals. This case report describes the histologic findings of a human symptomatic irreversible pulpitis immature permanent tooth with most of the pulp removed after a revascularization/regeneration procedure...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28390826/estimation-of-date-of-death-through-wound-healing-of-an-extraction-socket-a-case-report
#3
Joan Viciano, Ruggero D'Anastasio, Cristian D'Ovidio, Sara Costantini, Aldo Carnevale, Luigi Capasso
Surgical extraction of teeth due to dental pathologies is a relatively common procedure in modern man. The healing of the wound that results occurs in gradual and sequential stages, such that the analysis of this repair process can be very useful in forensic investigations on human remains. The following study reports on a particular case where the remodeling of a tooth socket allowed an estimation of the time that had elapsed from the day of the surgical extraction of the tooth to the time of death. The corpse was that of a woman of 34 years...
March 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28390134/primordial-odontogenic-tumor-an-immunohistochemical-profile
#4
R Bologna-Molina, T Mikami, V Pereira-Prado, F-R Pires, R Carlos-Bregni, A Mosqueda-Taylor
BACKGROUND: Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28365680/pro-inflammatory-cytokine-tnf-%C3%AE-attenuates-bmp9-induced-osteo-odontoblastic-differentiation-of-the-stem-cells-of-dental-apical-papilla-scaps
#5
Feilong Wang, Ying Jiang, Xia Huang, Qiao Liu, Yan Zhang, Wenping Luo, Fugui Zhang, Pengfei Zhou, Juhong Lin, Hongmei Zhang
BACKGROUND/AIMS: Periapical periodontitis is a common oral disease caused by bacterial invasion of the tooth pulp, which usually leads to local release of pro-inflammatory cytokines and osteolytic lesion. This study is intended to examine the effect of TNF-α on BMP9-induced osteogenic differentiation of the stem cells of dental apical papilla (SCAPs). METHODS: Rat model of periapical periodontitis was established. TNF-α expression was assessed. Osteogenic markers and ectopic bone formation in iSCAPs were analyzed upon BMP9 and TNF-α treatment...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28361313/functional-tooth-regeneration
#6
Masamitsu Oshima, Miho Ogawa, Takashi Tsuji
Three-dimensional organogenesis in vivo is principally regulated by the spatiotemporal developmental process that relies on the cellular behavior such as cell growth, migration, differentiation, and cell-to-cell interaction. Organ development and morphogenesis have been elucidated to be regulated by the proper transient expression of various signaling molecules including cytokines, extracellular matrix, and adhesion molecules based on the epithelial and mesenchymal interactions. Current bioengineering technology for regenerating three-dimensional organ has progressed to the replication of organogenesis, thereby enabling the development of fully functional bioengineered organs using bioengineered organ germs that are generated from immature stem cells via tissue engineering technology in vitro...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28342218/histological-assessment-of-regenerative-endodontic-treatment-in-animal-studies-with-different-scaffolds-a-systematic-review
#7
REVIEW
Milad Altaii, Lindsay Richards, Giampiero Rossi-Fedele
BACKGROUND/AIM: The concept of regenerative endodontic procedures remains controversial. The aim of this study was to evaluate the histology of the tissues formed in immature animal teeth with necrotic and infected pulps after attempted endodontic regeneration procedures using different scaffolds. DESIGN: A systematic electronic literature search was performed in PubMed, Web of Science, Scopus, EMBASE, DOSS, and Cochrane Library databases. The terms used were a combination of the following: "immature permanent necrotic tooth or teeth" or "open apex or apices" and "regeneration or revitalization or revascularization" and "histology...
March 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28341745/phospholipase-c-related-but-catalytically-inactive-protein-prip-upregulates-osteoclast-differentiation-via-calcium-calcineurin-nfatc1-signaling
#8
Ayako Murakami, Miho Matsuda, Yui Harada, Masato Hirata
Phospholipase C-related, but catalytically inactive protein (PRIP) was previously identified as a novel inositol 1,4,5-trisphosphate-binding protein with a domain organization similar to that of phospholipase C-δ, but lacking phospholipase activity. We recently showed that PRIP gene knockout (KO) in mice increases bone formation and concomitantly decreases bone resorption, resulting in increased bone mineral density and trabecular bone volume. However, the role of PRIP in osteoclastogenesis has not yet been fully elucidated...
March 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28294199/management-of-an-immature-partially-necrotic-permanent-molar-by-pulp-revascularization-%C3%A2-two-year-follow-up
#9
Julian Schmoeckel, Mhd Said Mourad, Christian H Splieth, Ruth M Santamaria
Root canal treatment of immature teeth is considered a great challenge for both the dentist and the patient. The thinness of the root canals walls and the lack of an apical barrier leads to unpredictable treatment results. Revascularization is a novel promising treatment option in the field of regenerative endodontics for management of immature necrotic permanent teeth. This case presents a successful treatment of an 8-year-old patient with a partially necrotic, immature permanent mandibular right first molar pulp by revascularization...
March 14, 2017: Quintessence International
https://www.readbyqxmd.com/read/28282516/f-spondin-negatively-regulates-dental-follicle-differentiation-through-the-inhibition-of-tgf-%C3%AE-activity
#10
Ai Orimoto, Misaki Kurokawa, Keisuke Handa, Masaki Ishikawa, Eisaku Nishida, Makoto Aino, Akio Mitani, Miho Ogawa, Takashi Tsuji, Masahiro Saito
OBJECTIVE: F-spondin is an extracellular matrix (ECM) protein that belongs to the thrombospondin type I repeat superfamily and is a negative regulator of bone mass. We have previously shown that f-spondin is specifically expressed in the dental follicle (DF), which gives rise to the periodontal ligament (PDL) during the tooth root formation stage. To investigate the molecular mechanism of PDL formation, we investigated the function of f-spondin in DF differentiation. DESIGN: The expression patterning of f-spondin in the developing tooth germ was compared with that of periodontal ligament-related genes, including runx2, type I collagen and periostin, by in situ hybridization analysis...
March 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28218034/extensive-maxillary-odontomas-in-2-dogs
#11
Naomi K Hoyer, Kristin M Bannon, Cynthia M Bell, Jason W Soukup
Two immature male dogs were presented for the treatment of extensive maxillary compound odontomas. In both cases, clinical evaluation and diagnostic imaging revealed extensive lesions invading and displacing anatomical structures of the maxilla. Histopathology confirmed the diagnoses in both cases. One dog was treated with partial rostral maxillectomy, and the other dog was treated with enucleation of the cystic lining and removal of tooth-like structures through a lateral rhinotomy utilizing an intraoral approach...
December 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28216269/antibacterial-effects-of-antimicrobials-used-in-regenerative-endodontics-against-biofilm-bacteria-obtained-from-mature-and-immature-teeth-with-necrotic-pulps
#12
Jordon C Jacobs, Alex Troxel, Ygal Ehrlich, Kenneth Spolnik, Josef S Bringas, Richard L Gregory, Ghaeth H Yassen
INTRODUCTION: We investigated the direct and residual antibacterial effects of intracanal antimicrobials against bacterial biofilms obtained from infected mature and immature teeth with necrotic pulps. METHODS: Sterile dentin slabs (n = 100) were inoculated with bacterial biofilms obtained from root canals of an immature or a mature tooth with pulpal necrosis and incubated anaerobically for 3 weeks (n = 50 per biofilm). Dentin infected with each type of biofilm received 1 week of treatment with 1 or 5 mg/mL double antibiotic paste (DAP) in methylcellulose hydrogels, calcium hydroxide, or placebo paste or received no treatment (n = 10)...
April 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28210431/vertical-root-fracture-resistance-of-simulated-immature-permanent-teeth-filled-with-mta-using-different-vehicles
#13
Hacer Aksel, Sevinc Askerbeyli-Örs, Derya Deniz-Sungur
BACKGROUND: The aim of the study is to evaluate the resistance vertical root fracture (VRF) of mineral trioxide aggregate (MTA) filled-immature permanent roots by using three different vehicles. MATERIAL AND METHODS: Forty-extracted human single-rooted mandibular premolars were selected and the root length was standardized to the length of 9 mm. For simulation of immature tooth apices, peeso reamers were introduced into the root canals and the prepared roots were assigned into three experimental groups according the used vehicle (distilled water-DW, prophylene glycol-PG, chlorhexidine-CHX) and control group (n=10)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28196330/decellularized-human-dental-pulp-as-a-scaffold-for-regenerative-endodontics
#14
J S Song, K Takimoto, M Jeon, J Vadakekalam, N B Ruparel, A Diogenes
Teeth undergo postnatal organogenesis relatively late in life and only complete full maturation a few years after the crown first erupts in the oral cavity. At this stage, development can be arrested if the tooth organ is damaged by either trauma or caries. Regenerative endodontic procedures (REPs) are a treatment alternative to conventional root canal treatment for immature teeth. These procedures rely on the transfer of apically positioned stem cells, including stem cells of the apical papilla (SCAP), into the root canal system...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28194367/retreatment-of-failed-regenerative-endodontic-of-orthodontically-treated-immature-permanent-maxillary-central-incisor-a-case-report
#15
Musaed Fahad Al-Tammami, Saad A Al-Nazhan
A revascularization procedure was shown to be the best alternative therapy for immature teeth with necrotic pulp and apical infection. A 12 year old female with a history of trauma to her upper central incisor and a sinus tract was referred for endodontic treatment. She was an active orthodontic patient and had undergone regenerative endodontic treatment for the past 2 years. Clinical examination revealed no response to sensibility, percussion, and palpation tests. The preoperative radiograph showed an open apex and apical rarefaction...
February 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28190588/survival-of-the-apical-papilla-and-its-resident-stem-cells-in-a-case-of-advanced-pulpal-necrosis-and-apical-periodontitis
#16
Vanessa Chrepa, Brandon Pitcher, Michael A Henry, Anibal Diogenes
INTRODUCTION: Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis. The characteristics and phenotype of this tissue in the presence of inflammation are largely unknown. The purpose of this study was to characterize a human apical papilla sample that was isolated from an immature tooth with pulp necrosis and apical periodontitis...
April 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28179936/vital-pulp-therapy-with-calcium-silicate-cements-report-of-two-cases
#17
Hengameh Ashraf, Afsaneh Rahmati, Neda Amini
This article describes successful use of calcium-enriched mixture (CEM) cement and Biodentine in apexogenesis treatment in two 8-year-old patients, one with immature permanent molar diagnosed primarily with irreversible pulpitis and the other with partially vital maxillary central incisor. After access cavity preparation, partial pulpotomy in molar and full pulpotomy in central was performed, and the remaining pulps was capped with either Biodentine or CEM cement, in each tooth. The crowns were restored with composite filling material at the following visit...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28132710/treatment-outcomes-of-apexification-or-revascularization-in-nonvital-immature-permanent-teeth-a-retrospective-study
#18
Jidapa Silujjai, Pairoj Linsuwanont
INTRODUCTION: The purposes of this retrospective study were to evaluate the clinical and radiographic outcomes of mineral trioxide aggregate apexification and revascularization in nonvital immature permanent teeth and to analyze factors influencing treatment outcome. METHODS: Forty-six cases (29 cases of apexification and 17 cases of revascularization) were recruited into this study. Patients' preoperative and postoperative information was analyzed. Treatment outcomes were categorized as a success or failure and functional retention...
February 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28106508/gelma-encapsulated-hdpscs-and-huvecs-for-dental-pulp-regeneration
#19
A Khayat, N Monteiro, E E Smith, S Pagni, W Zhang, A Khademhosseini, P C Yelick
Pulpal revascularization is commonly used in the dental clinic to obtain apical closure of immature permanent teeth with thin dentinal walls. Although sometimes successful, stimulating bleeding from the periapical area of the tooth can be challenging and in turn may deleteriously affect tooth root maturation. Our objective here was to define reliable methods to regenerate pulp-like tissues in tooth root segments (RSs). G1 RSs were injected with human dental pulp stem cells (hDPSCs) and human umbilical vein endothelial cells (HUVECs) encapsulated in 5% gelatin methacrylate (GelMA) hydrogel...
February 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28050518/revitalization-of-an-immature-permanent-mandibular-molar-with-a-necrotic-pulp-using-platelet-rich-fibrin-a-case-report
#20
Dayalan Subash, Krishnamma Shoba, Shibu Aman, Srinivasan Kumar Indu Bharkavi
Any insult to the pulp during its development causes cessation of dentin formation and root growth. Pulpal status and degree of root development are the decisive factors in the treatment approach. Various treatment options have been tried like surgery with root-end sealing, calcium hydroxide-apexification, placement of apical plug and regenerative endodontic procedures to induce apexogenesis. An ideal scenario for a necrosed tooth with immature root would be continued root development coupled with regeneration of pulp tissue...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
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