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https://www.readbyqxmd.com/read/29913998/early-maladaptive-schemas-in-finnish-adult-chronic-male-and-female-pain-patients
#1
Tom H J Saariaho, Anita S I Saariaho, Irma A Karila, Matti I Joukamaa
Background and aims of the study The connection between chronic pain and traumatic experiences in childhood has been established in several studies. The association of emotional maltreatment with chronic pain has been studied, but to a lesser degree. Schema therapy [24] is an extension of cognitive therapy and presents the early maladaptive schema (EMS) concept. EMSs reflect early, mainly emotional maltreatment. The aim of the present study was to examine the existence of EMSs, the association between EMSs and pain variables and EMS driven patterns...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29891793/the-effects-of-temperament-on-depression-according-to-the-schema-model-a-scoping-review
#2
REVIEW
Charmaine Ruling Lim, Joanna Barlas, Roger Chun Man Ho
Background : Recent studies have shown that not every depressed patient responds to Cognitive Behavioral Therapy, and some of those who do relapse upon termination. Due to its dual focus on the past and present, Schema Model (SM) represents a promising alternative model to understand depression. However, studies examining SM often operationalize the same construct differently, resulting in inconsistent evidence of change. There is no known review clarifying (1) how best to assess schema constructs; and (2) the relevant pathways to depression, without which, the empirical basis for SM cannot be examined...
June 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29874922/cardiovascular-safety-of-psychiatric-agents-a-cautionary-tale
#3
Theodora A Manolis, Antonis A Manolis, Antonis S Manolis
Psychiatric agents are among the most commonly prescribed medications. Despite the advent of newer generation agents, patients receiving them still experience cardiovascular (CV) side effects. However, these agents may have heterogeneous properties, calling for an individualized approach based on efficacy and also on the particular side effect profile of each specific agent. Proarrhythmic effects arising from drug-induced long-QT syndrome and consequent potentially life-threatening polymorphic ventricular arrhythmias in the form of torsade de pointes, the metabolic syndrome contributing to atherosclerosis and acute coronary syndromes, and drug-induced orthostatic hypotension raise major concerns...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29862221/the-effectiveness-of-emotional-schema-therapy-on-the-emotional-schemas-and-emotional-regulation-in-irritable-bowel-syndrome-single-subject-design
#4
Arefeh Erfan, Ahmad Ali Noorbala, Saeed Karbasi Amel, Abolfazl Mohammadi, Peyman Adibi
Background: Positive and negative emotional states are the most important factors in treatment and prevention process of psychosomatic diseases. This research aimed to investigate the effectiveness of emotional schemas' therapy on emotional schemas' modification and difficulties of emotion regulation in women with irritable bowel syndrome (IBS). Materials and Methods: This research was implemented in the framework of single-subject experimental design using step-wise multiple baselines plan...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29794204/anti-proteases-and-alpha-1-antitrypsin-augmentation-therapy
#5
Charlie Strange
Alpha-1 antitrypsin deficiency is a genetic disease that first highlighted the importance of protease balance in normal lung homeostasis. Proteases such as neutrophil elastase are important in many pulmonary diseases. However, the first commercially licensed anti-protease therapy was used for emphysema in alpha-1 antitrypsin deficiency. The 4 commercial alpha-1 protease inhibitor preparations in the United States are currently given intravenously to augment the serum and alveolar epithelial lining fluid concentrations of alpha-1 antitrypsin...
June 2018: Respiratory Care
https://www.readbyqxmd.com/read/29755954/immune-response-generated-with-the-administration-of-autologous-dendritic-cells-pulsed-with-an-allogenic-tumoral-cell-lines-lysate-in-patients-with-newly-diagnosed-diffuse-intrinsic-pontine-glioma
#6
Daniel Benitez-Ribas, Raquel Cabezón, Georgina Flórez-Grau, Mari Carmen Molero, Patricia Puerta, Antonio Guillen, Sonia Paco, Angel M Carcaboso, Vicente Santa-Maria Lopez, Ofelia Cruz, Carmen de Torres, Noelia Salvador, Manel Juan, Jaume Mora, Andres Morales La Madrid
Background and objective: Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore, potential antitumor activity for disease control. DCs vaccines have been shown to reactivate tumor-specific T cells in both clinical and preclinical settings. We designed a phase Ib immunotherapy (IT) clinical trial with the use of autologous dendritic cells (ADCs) pulsed with an allogeneic tumors cell-lines lysate in patients with newly diagnosed DIPG after irradiation (radiation therapy)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29737529/posttraumatic-headache-classification-by-symptom-based-clinical-profiles
#7
Sylvia Lucas, Andrew H Ahn
There are currently no accepted therapies for posttraumatic headache (PTH). In order to meet the urgent need for effective therapies for PTH, we must continue to address fundamental gaps in our understanding of the clinical course and impact of PTH. Here we examine the existing schema used to characterize the clinical characteristics of PTH, including the International Classification of Headache Disorders (ICHD). There remain unresolved questions about whether to classify patients based on the extent of brain injury or on clinical symptom profiles...
May 8, 2018: Headache
https://www.readbyqxmd.com/read/29672073/positive-clinical-psychology-and-schema-therapy-st-the-development-of-the-young-positive-schema-questionnaire-ypsq-to-complement-the-young-schema-questionnaire-3-short-form-ysq-s3
#8
John P Louis, Alex M Wood, George Lockwood, Moon-Ho Ringo Ho, Eamonn Ferguson
Negative schemas have been widely recognized as being linked to psychopathology and mental health, and they are central to the Schema Therapy (ST) model. This study is the first to report on the psychometric properties of the Young Positive Schema Questionnaire (YPSQ). In a combined community sample (Manila, Philippines, n = 559; Bangalore, India, n = 350; Singapore, n = 628), we identified a 56-item, 14-factor solution for the YPSQ. Multigroup confirmatory factor analysis supported the 14-factor model using data from two other independent samples: an Eastern sample from Kuala Lumpur, Malaysia (n = 229) and a Western sample from the United States (n = 214)...
April 19, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29663340/molecular-signatures-in-hepatocellular-carcinoma-a-step-toward-rationally-designed-cancer-therapy
#9
REVIEW
Derek J Erstad, Bryan C Fuchs, Kenneth K Tanabe
Molecular characterization of hepatocellular carcinoma (HCC) has greatly improved our understanding of disease pathogenesis. Mutational analysis, RNA and microRNA expression profiling, and epigenetic characterization have revealed common aberrations in oncogenes and tumor suppressors that correlate with disease biology and serve as a guide for the rational design of targeted therapies. These approaches have also led to the discovery of novel targets, including mutations in isocitrate dehydrogenase and chromatin remodeling enzymes...
April 17, 2018: Cancer
https://www.readbyqxmd.com/read/29601274/revisiting-the-safe-place-method-and-regulatory-aspects-in-psychotherapy-when-easing-allostatic-overload-in-traumatized-patients
#10
Anna Gerge
Safe-place inductions are considered important altered states of consciousness (ASC) to be (re)installed during trauma-informed psychotherapy. Coregulation aimed at changing implicit relational knowing and increasing integration and coherence through relational work and hypnotic techniques is crucial, as clients' abilities to self-soothe and regulate have become seriously impaired. Thus, resource-oriented metaphors as inner strength imagery is advocated. Also, methods such as creative-arts therapy and neurofeedback will induce ASCs, as most methods used with complex traumatized clients, due to their high hypnotizability...
April 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29485047/american-association-of-physicists-in-medicine-task-group-263-standardizing-nomenclatures-in-radiation-oncology
#11
REVIEW
Charles S Mayo, Jean M Moran, Walter Bosch, Ying Xiao, Todd McNutt, Richard Popple, Jeff Michalski, Mary Feng, Lawrence B Marks, Clifton D Fuller, Ellen Yorke, Jatinder Palta, Peter E Gabriel, Andrea Molineu, Martha M Matuszak, Elizabeth Covington, Kathryn Masi, Susan L Richardson, Timothy Ritter, Tomasz Morgas, Stella Flampouri, Lakshmi Santanam, Joseph A Moore, Thomas G Purdie, Robert C Miller, Coen Hurkmans, Judy Adams, Qing-Rong Jackie Wu, Colleen J Fox, Ramon Alfredo Siochi, Norman L Brown, Wilko Verbakel, Yves Archambault, Steven J Chmura, Andre L Dekker, Don G Eagle, Thomas J Fitzgerald, Theodore Hong, Rishabh Kapoor, Beth Lansing, Shruti Jolly, Mary E Napolitano, James Percy, Mark S Rose, Salim Siddiqui, Christof Schadt, William E Simon, William L Straube, Sara T St James, Kenneth Ulin, Sue S Yom, Torunn I Yock
A substantial barrier to the single- and multi-institutional aggregation of data to supporting clinical trials, practice quality improvement efforts, and development of big data analytics resource systems is the lack of standardized nomenclatures for expressing dosimetric data. To address this issue, the American Association of Physicists in Medicine (AAPM) Task Group 263 was charged with providing nomenclature guidelines and values in radiation oncology for use in clinical trials, data-pooling initiatives, population-based studies, and routine clinical care by standardizing: (1) structure names across image processing and treatment planning system platforms; (2) nomenclature for dosimetric data (eg, dose-volume histogram [DVH]-based metrics); (3) templates for clinical trial groups and users of an initial subset of software platforms to facilitate adoption of the standards; (4) formalism for nomenclature schema, which can accommodate the addition of other structures defined in the future...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29485009/oral-submucous-fibrosis-as-an-overhealing-wound-implications-in-malignant-transformation
#12
Mohit Sharma, Smitha Sammith Shetty, Raghu Radhakrishnan
BACKGROUND: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. OBJECTIVE: The objective of this article is to decipher the pathogenesis of oral submucous fibrosis in order to identify novel drug targets...
February 26, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29466692/anti-programmed-cell-death-1-pd-1-monoclonal-antibodies-in-treating-advanced-melanoma-a-clinical-update
#13
Van Anh Trinh, Jocelyn Joseph, Wen-Jen Hwu
Since their approval by regulatory agencies worldwide, the anti-PD-1 monoclonal antibodies (mAbs), as monotherapy or in combination with ipilimumab, have become the standard frontline therapy for advanced BRAF-wild-type melanoma and an eminent rival to targeted therapy in the first-line setting for unresectable BRAF-mutated melanoma. Mature survival data from randomized phase 3 trials have emerged, confirming their position in the current treatment schema for advanced melanoma. Recently, the clinical utility of anti-PD-1 agents has extended into other disease settings, such as resected high-risk melanomas, non-cutaneous subtypes, and brain metastases...
January 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29463474/sexual-self-schema-scale-for-women-validation-and-psychometric-properties-of-the-polish-version
#14
Krzysztof Nowosielski, Konrad S Jankowski, Robert Kowalczyk, Jacek Kurpisz, Małgorzata Normantowicz-Zakrzewska, Aleksandra Krasowska
INTRODUCTION: The sexual self-schema is a part of a broader concept of the self that is believed to be crucial for intrapersonal and interpersonal sexual relationships. AIM: To develop and perform psychometric validation of the Polish version of the Sexual Self-Schema Scale for Women (SSSS-W-PL). METHODS: 561 women 18 to 55 years old were included in the final analysis. Linguistic validation was performed in 4 steps in line with the MAPI Institute guidelines...
February 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29433958/an-ontology-driven-clinical-decision-support-system-iddap-for-infectious-disease-diagnosis-and-antibiotic-prescription
#15
Ying Shen, Kaiqi Yuan, Daoyuan Chen, Joël Colloc, Min Yang, Yaliang Li, Kai Lei
BACKGROUND: The available antibiotic decision-making systems were developed from a physician's perspective. However, because infectious diseases are common, many patients desire access to knowledge via a search engine. Although the use of antibiotics should, in principle, be subject to a doctor's advice, many patients take them without authorization, and some people cannot easily or rapidly consult a doctor. In such cases, a reliable antibiotic prescription support system is needed. METHODS AND RESULTS: This study describes the construction and optimization of the sensitivity and specificity of a decision support system named IDDAP, which is based on ontologies for infectious disease diagnosis and antibiotic therapy...
March 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29378221/canine-sarcomas-as-a-surrogate-for-the-human-disease
#16
REVIEW
Daniel L Gustafson, Dawn L Duval, Daniel P Regan, Douglas H Thamm
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds...
March 9, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29371141/the-impact-of-childhood-sexual-abuse-on-women-s-sexual-health-a-comprehensive-review
#17
REVIEW
Carey S Pulverman, Chelsea D Kilimnik, Cindy M Meston
INTRODUCTION: Childhood sexual abuse (CSA) has been identified as a potent risk factor for sexual dysfunction. Certain characteristics of the abuse experience, such as repeated abuse, appear to affect the risk of developing sexual dysfunction. Despite the robust findings that CSA can be detrimental to sexual function, there is little consensus on the exact mechanisms that lead to these difficulties. AIM: To summarize the most up-to-date research on the relation between CSA and women's sexual function...
April 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29370876/the-development-and-psychometric-evaluation-of-the-group-schema-therapy-rating-scale-revised
#18
Emily Bastick, Suili Bot, Simone J W Verhagen, Gerhard Zarbock, Joan Farrell, Odette Brand-de Wilde, Arnoud Arntz, Christopher William Lee
BACKGROUND: Recent research has supported the efficacy of schema therapy as a treatment for personality disorders. A group format has been developed (group schema therapy; GST), which has been suggested to improve both the clinical and cost-effectiveness of the treatment. AIMS: Efficacy studies of GST need to assess treatment fidelity. The aims of the present study were to improve, describe and evaluate a fidelity measure for GST, the Group Schema Therapy Rating Scale - Revised (GSTRS-R)...
January 26, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29356610/restoring-body-image-after-cancer-rebic-results-of-a-randomized-controlled-trial
#19
Mary Jane Esplen, Jiahui Wong, Ellen Warner, Brenda Toner
Purpose This study aimed to test a group psychosocial intervention focused on improving disturbances of body image (BI), sexual functioning, and quality of life in breast cancer (BC) survivors. Methods A prospective, randomized controlled trial was conducted to assess the efficacy of an 8-week group intervention in women after BC treatment. The manual-based intervention combined two powerful ingredients: expressive guided-imagery exercises integrated within a model of group-therapy principles. The intervention facilitates exploration of identity, the development of new self-schemas, and personal growth...
March 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29349097/universal-method-for-the-purification-of-recombinant-aav-vectors-of-differing-serotypes
#20
Shelley A Nass, Maryellen A Mattingly, Denise A Woodcock, Brenda L Burnham, Jeffrey A Ardinger, Shayla E Osmond, Amy M Frederick, Abraham Scaria, Seng H Cheng, Catherine R O'Riordan
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To date, most reported purification schemas are serotype dependent, requiring method development for each AAV gene therapy product. Here, we describe a platform purification process that is compatible with the purification of multiple AAV serotypes. The method generates vector preparations of high purity that are enriched for capsids with full vector genomes, and that minimizes the fractional content of empty capsids...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
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