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https://www.readbyqxmd.com/read/28223022/early-identification-of-mild-cognitive-impairment-using-incomplete-random-forest-robust-support-vector-machine-and-fdg-pet-imaging
#1
Shen Lu, Yong Xia, Weidong Cai, Michael Fulham, David Dagan Feng
Alzheimer's disease (AD) is the most common type of dementia and will be an increasing health problem in society as the population ages. Mild cognitive impairment (MCI) is considered to be a prodromal stage of AD. The ability to identify subjects with MCI will be increasingly important as disease modifying therapies for AD are developed. We propose a semi-supervised learning method based on robust optimization for the identification of MCI from [18F]Fluorodeoxyglucose PET scans. We extracted three groups of spatial features from the cortical and subcortical regions of each FDG-PET image volume...
February 7, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28217649/effects-of-the-schema-therapy-and-mindfulness-on-the-maladaptive-schemas-hold-by-the-psoriasis-patients-with-the-psychopathology-symptoms
#2
Parvin Jamali Gojani, Mohsen Masjedi, Shahnaz Khaleghipour, Ehsan Behzadi
BACKGROUND: This study aimed to compare the effects of the schema along with mindfulness-based therapies in the psoriasis patients. MATERIALS AND METHODS: This semi-experimental study with post- and pre-tests was conducted on the psoriasis patients in the Dermatology Clinic of the Isfahan Alzahra Hospital, Iran using the convenience sampling in 2014. The patients had a low general health score. The experimental groups included two treatment groups of schema-based (n = 8) and mindfulness (n = 8)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28194611/using-three-dimensional-echocardiography-to-guide-left-ventricle-lead-position-in-cardiac-resynchronization-therapy-does-it-make-any-difference
#3
Haitham A Badran, John Z Kamel, Tarek R Mohamed, Mohamed A Abdelhamid
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with advanced heart failure. Nearly 30% of candidates are inadequate responders. Proper patient selection, left ventricle (LV) lead placement optimization, and optimization of the programming of the CRT device are important approaches to improve outcome of CRT. We examined the role of three-dimensional (3D) echocardiography in determining the optimal LV lead position as a method of optimizing CRT response...
February 13, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28190407/validity-evidence-of-the-spanish-version-of-the-automatic-thoughts-questionnaire-8-in-colombia
#4
Francisco J Ruiz, Juan C Suárez-Falcón, Diana Riaño-Hernández
The Automatic Thoughts Questionnaire (ATQ) is a widely used, 30-item, 5-point Likert-type scale that measures the frequency of negative automatic thoughts as experienced by individuals suffering from depression. However, there is some controversy about the factor structure of the ATQ, and its application can be too time-consuming for survey research. Accordingly, an abbreviated, 8-item version of the ATQ has been proposed. The aim of this study was to analyze the validity evidence of the Spanish version of the ATQ-8 in Colombia...
February 13, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28169430/phase-ii-study-of-bendamustine-bortezomib-and-dexamethasone-bbd-in-the-first-line-treatment-of-patients-with-multiple-myeloma-who-are-not-candidates-for-high-dose-chemotherapy
#5
Jesus G Berdeja, Todd Bauer, Edward Arrowsmith, James Essell, Patrick Murphy, James A Reeves, Ralph V Boccia, William Donnellan, Ian Flinn
The combination of bendamustine, bortezomib and dexamethasone (BBD) was evaluated as a first-line therapy for multiple myeloma. The original treatment regimen of bendamustine 80 mg/m(2) , days 1, 4; bortezomib 1·3 mg/m(2) , days 1, 4, 8, 11; dexamethasone 40 mg, days 1, 2, 3, 4 on a 28-day cycle (up to 8 cycles) was efficacious but determined relatively toxic in an interim analysis. The regimen was amended to bendamustine 80 mg/m(2) , days 1, 2; bortezomib 1·3 mg/m(2) , days 1, 8, 15; dexamethasone 20 mg, days 1, 2, 8, 9, 15, 16 every 28 days (up to 8 cycles), then maintenance 1·3 mg/m(2) IV bortezomib every 2 weeks...
February 7, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28152688/a-new-digital-classification-schema-to-detect-treatment-variances-and-enable-value-based-payment-reforms
#6
Eric V Schultz, Kelly Choi, William Kea, Augie Smith, Cindy Kim, Matthew Axelrod, Teresa Fletcher, Matthew Love, Ruth Pe Benito, Samira Daswani, Sukhi Kaur, Kathyrn Tanenbaum, James Schaffer, Ali Hasan, Dilip Raj, Kumar Bharath Prabhu, Kiran Suryadevara, Ryan Callahan, Stuart L Goldberg
: 28 Background: Value based payment reforms which improve the outcome to cost ratio (paying for outcomes not for services) require detailed information on both elements. Although the digitalization of medicine via the EHR may facilitate data collection, the imprecise ICD9 and ICD10 schemas hinder analysis (eg: all breast cancers are ICD9 174.9). A more precise classification schema that accounts for biologic variances to allow analysis (and reduction) of treatment variances is needed...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139419/prostate-mri-for-brachytherapists-diagnosis-imaging-pitfalls-and-post-therapy-assessment
#7
REVIEW
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
Optimal integration of multiparametric MRI (mp MRI) into prostate brachytherapy practice necessitates an understanding of imaging findings pertinent to prostate cancer detection and staging. This review will summarize prostate cancer imaging findings and tumor staging on mp MRI, including an overview of the Prostate Imaging Reporting and Data System (PIRADS)-structured reporting schema, mp MRI findings observed in the post-therapy setting including cases of post-treatment recurrence, and MRI concepts integral to successful salvage brachytherapy...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28091817/teratomas-of-the-cranial-vault-a-systematic-analysis-of-clinical-outcomes-stratified-by-histopathological-subtypes
#8
Carlito Lagman, Timothy T Bui, Brittany L Voth, Lawrance K Chung, David J Seo, Courtney Duong, Mark R Libowitz, Naomi E Walker, Daniel T Nagasawa, Isaac Yang
BACKGROUND: Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses: mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas. METHODS: We performed a systematic analysis of the published literature to identify studies describing patients with intracranial teratomas diagnosed with magnetic resonance imaging (MRI) and presenting definite information on histologies, therapies, and outcomes at a minimum follow-up of 2 years...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28063545/pr%C3%A3-vention-de-l-infection-n%C3%A3-onatale-%C3%A3-streptocoques-du-groupe-b-d-apparition-pr%C3%A3-coce
#9
Deborah Money, Victoria M Allen
OBJECTIF: Analyser les données issues de la littérature et formuler des recommandations sur la prise en charge des parturientes en vue de prévenir l'infection néonatale à streptocoques du groupe B d'apparition précoce. Parmi les révisions clés que renferme la présente directive clinique mise à jour, on trouve des modifications quant aux recommandations en ce qui concerne les schémas posologiques d'antibioprophylaxie, les épreuves de sensibilité et la prise en charge des femmes présentant une rupture prématurée des membranes...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28050150/risk-stratification-treatment-selection-and-transplant-eligibility-in-multiple-myeloma-a-qualitative-study-of-the-perspectives-and-self-reported-practices-of-oncologists
#10
T W LeBlanc, A Howson, W Turell, P Sheldon, S C Locke, S A Tuchman, C Gasparetto, S Kaura, Z M Khan, A P Abernethy
BACKGROUND: Since the early 2000s, treatment options for multiple myeloma have rapidly expanded, adding significant complexity to the management of this disease. To our knowledge, no systematic qualitative research on clinical decision-making in multiple myeloma has been published. We sought to characterize how physicians view and implement guidelines and incorporate novel approaches into patient care. METHODS: We designed a semi-structured qualitative interview guide informed by literature review and an expert advisory panel...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28048872/we-fg-bra-10-radiodosimetry-of-a-novel-alpha-particle-therapy-targeted-to-uveal-melanoma-absorbed-dose-to-organs-in-mice
#11
Christopher J Tichacek, Narges K Tafreshi, Mikalai M Budzevich, Epifanio Ruiz, Thaddeus J Wadas, Mark L McLaughlin, Eduardo G Moros, David L Morse
PURPOSE: The melanocortin-1 receptor (MC1R) is expressed in 94% of uveal melanomas and is described as an ideal target for this untreatable disease. MC1RL is a high affinity MC1R specific peptidomimetic ligand that can serve as a scaffold for therapeutic conjugates such as alpha particle emitting isotopes. The purpose of this study was to assess normal tissue distribution and risk as a result of using the DOTA chelator conjugated to MC1RL to deliver (225) Ac: MC1RL-DOTA-(225) Ac. METHODS: 17 non-tumor bearing BALB/c mice were intravenously injected with the novel MC1RL-DOTA-(225) Ac radiopharmaceutical with an average initial administered activity of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035734/does-schema-therapy-change-schemas-and-symptoms-a-systematic-review-across-mental-health-disorders
#12
REVIEW
Christopher D J Taylor, Penny Bee, Gillian Haddock
PURPOSE: Schema therapy was first applied to individuals with borderline personality disorder (BPD) over 20 years ago, and more recent work has suggested efficacy across a range of disorders. The present review aimed to systematically synthesize evidence for the efficacy and effectiveness of schema therapy in reducing early maladaptive schema (EMS) and improving symptoms as applied to a range of mental health disorders in adults including BPD, other personality disorders, eating disorders, anxiety disorders, and post-traumatic stress disorder...
December 30, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28012033/early-maladaptive-schemas-in-adult-patients-with-attention-deficit-hyperactivity-disorder
#13
Alexandra Philipsen, Alexandra P Lam, Sigrid Breit, Caroline Lücke, Helge H Müller, Swantje Matthies
The main purpose of this study was to examine whether adult patients with attention deficit hyperactivity disorder (ADHD) demonstrate sets of dysfunctional cognitive beliefs and behavioural tendencies according to Jeffrey Young's schema-focused therapy model. Sets of dysfunctional beliefs (maladaptive schemas) were assessed with the Young Schema Questionnaire (YSQ-S2) in 78 adult ADHD patients and 80 control subjects. Patients with ADHD scored significantly higher than the control group on almost all maladaptive schemas...
December 23, 2016: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/27992139/b-zell-lymphome-der-haut-pathogenese-diagnostik-und-therapie
#14
Jan P Nicolay, Marion Wobser
Primär kutane B-Zell-Lymphome (PCBCL) beschreiben reifzellige lymphoproliferative Erkrankungen der B-Zell-Reihe, die primär die Haut betreffen. Die Biologie und der klinische Verlauf der einzelnen PCBCL-Subtypen variieren untereinander stark und unterscheiden sich grundsätzlich von primär nodalen und systemischen B-Zell-Lymphomen. Primär kutane Marginalzonenlymphome (PCMZL) und primäre kutane follikuläre Keimzentrumslymphome (PCFCL) werden auf Grund ihres unkomplizierten Verlaufs und ihrer exzellenten Prognose zu den indolenten PCBCL gezählt...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27979915/neural-stem-cell-based-anti-cancer-gene-therapy-a-first-in-human-study-in-recurrent-high-grade-glioma-patients
#15
Jana Portnow, Timothy W Synold, Behnam Badie, Revathiswari Tirughana, Simon F Lacey, Massimo D'Apuzzo, Marianne Z Metz, Joseph Najbauer, Victoria Bedell, Tien Vo, Margarita Gutova, Paul Frankel, Mike Y Chen, Karen S Aboody
PURPOSE: Human neural stem cells (NSCs) are inherently tumor-tropic, making them attractive drug delivery vehicles. Toward this goal, we retrovirally transduced an immortalized, clonal NSC line to stably express cytosine deaminase (HB1.F3.CD.C21; CD-NSCs), which converts the prodrug 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU). EXPERIMENTAL DESIGN: Recurrent high grade glioma patients underwent intracranial administration of CD-NSCs during tumor resection or biopsy...
December 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27933020/feasibility-of-group-schema-therapy-for-outpatients-with-severe-borderline-personality-disorder-in-germany-a-pilot-study-with-three-year-follow-up
#16
Eva Fassbinder, Maren Schuetze, Annika Kranich, Valerija Sipos, Fritz Hohagen, Ida Shaw, Joan Farrell, Arnoud Arntz, Ulrich Schweiger
Borderline Personality Disorder (BPD) is a severe, challenging to treat mental disorder. Schema therapy (ST) as an individual therapy has been proven to be an effective psychological treatment for BPD. A group format of ST (GST) has been developed and evaluated in a randomized controlled trial in the United States and piloted in The Netherlands. These results suggest that GST speeds up and amplifies treatment effects of ST and might reduce delivery costs. However, feasibility in the German health care system and with BPD patients with high BPD severity and comorbidity, and frequent hospitalization, has not been tested to date...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27912159/changes-in-the-self-during-cognitive-behavioural-therapy-for-social-anxiety-disorder-a-systematic-review
#17
REVIEW
Bree Gregory, Lorna Peters
A consistent feature across cognitive-behavioural models of social anxiety disorder (SAD) is the central role of the self in the emergence and maintenance of the disorder. The strong emphasis placed on the self in these models and related empirical research has also been reflected in evidence-based treatments for the disorder. This systematic review provides an overview of the empirical literature investigating the role of self-related constructs (e.g., self-beliefs, self-images, self-focused attention) proposed in cognitive models of SAD, before examining how these constructs are modified during and following CBT for SAD...
November 23, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27878966/risk-adapted-stratification-for-optimally-intensive-treatment-assignment-of-pediatric-patients-with-non-hodgkin-lymphoma-is-an-effective-strategy-in-developing-countries
#18
Asim F Belgaumi, Mohammed Anas, Khawar S Siddiqui, Mohammed F Akhter, Amani Al-Kofide
BACKGROUND: Pediatric patients with non-Hodgkin lymphoma (NHL) in developing countries (DCs) present with greater tumor load even at lower stages and with comorbidities that impact therapy delivery. This causes toxic mortality with "standard" intensive protocols or recurrences with "gentler" treatment. OBJECTIVES: We developed and evaluated a risk stratification schema that guides intensity of therapy. DESIGN/METHODS: Sixty-nine patients were prospectively assigned to five risk groups (A-E; n = 6, 15, 16, 15, and 17) following staging and treated with protocols of risk-stratified intensity...
November 23, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27862056/integrating-social-justice-into-the-practice-of-cbft-a-critical-look-at-family-schemas
#19
Elizabeth O Parker, Teresa McDowell
Many families come to therapy struggling with the negative consequence of social inequity. Family therapy modalities have been developed to address these negative consequences and attend to power and social equity (Transformative family therapy: Just families in a just society. Boston, MA: Pearson Education; Socio-emotional relationship therapy. New York, NY: Springer). We argue that many family therapy modalities can be adapted to include social equity (Applying critical social theory in family therapy practice...
November 16, 2016: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/27844506/a-comparison-of-pre-dropout-and-temporary-rupture-sessions-in-psychotherapy
#20
I Volkan Gülüm, Gonca Soygüt, Jeremy D Safran
: Although numerous studies have investigated the relationship between the therapeutic alliance and dropout, most have focused on the relationship between alliance quality and psychotherapy outcomes. OBJECTIVE: To compare sessions with therapeutic alliance ruptures and two sessions prior to treatment dropout (pre-dropout) in terms of rupture subtypes, psychotherapists' behavior, attitudes, and session content. METHOD: We implemented quantitative methods to select the sessions and qualitative methods to analyze them...
November 15, 2016: Psychotherapy Research: Journal of the Society for Psychotherapy Research
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