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https://www.readbyqxmd.com/read/29433958/an-ontology-driven-clinical-decision-support-system-iddap-for-infectious-disease-diagnosis-and-antibiotic-prescription
#1
Ying Shen, Kaiqi Yuan, Daoyuan Chen, Joël Colloc, Min Yang, Yaliang Li, Kai Lei
BACKGROUND: The available antibiotic decision-making systems were developed from a physician's perspective. However, because infectious diseases are common, many patients desire access to knowledge via a search engine. Although the use of antibiotics should, in principle, be subject to a doctor's advice, many patients take them without authorization, and some people cannot easily or rapidly consult a doctor. In such cases, a reliable antibiotic prescription support system is needed. METHODS AND RESULTS: This study describes the construction and optimization of the sensitivity and specificity of a decision support system named IDDAP, which is based on ontologies for infectious disease diagnosis and antibiotic therapy...
February 9, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29378221/canine-sarcomas-as-a-surrogate-for-the-human-disease
#2
REVIEW
Daniel L Gustafson, Dawn L Duval, Daniel P Regan, Douglas H Thamm
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds...
January 26, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29371141/the-impact-of-childhood-sexual-abuse-on-women-s-sexual-health-a%C3%A2-comprehensive-review
#3
REVIEW
Carey S Pulverman, Chelsea D Kilimnik, Cindy M Meston
INTRODUCTION: Childhood sexual abuse (CSA) has been identified as a potent risk factor for sexual dysfunction. Certain characteristics of the abuse experience, such as repeated abuse, appear to affect the risk of developing sexual dysfunction. Despite the robust findings that CSA can be detrimental to sexual function, there is little consensus on the exact mechanisms that lead to these difficulties. AIM: To summarize the most up-to-date research on the relation between CSA and women's sexual function...
January 19, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29370876/the-development-and-psychometric-evaluation-of-the-group-schema-therapy-rating-scale-revised
#4
Emily Bastick, Suili Bot, Simone J W Verhagen, Gerhard Zarbock, Joan Farrell, Odette Brand-de Wilde, Arnoud Arntz, Christopher William Lee
BACKGROUND: Recent research has supported the efficacy of schema therapy as a treatment for personality disorders. A group format has been developed (group schema therapy; GST), which has been suggested to improve both the clinical and cost-effectiveness of the treatment. AIMS: Efficacy studies of GST need to assess treatment fidelity. The aims of the present study were to improve, describe and evaluate a fidelity measure for GST, the Group Schema Therapy Rating Scale - Revised (GSTRS-R)...
January 26, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29356610/restoring-body-image-after-cancer-rebic-results-of-a-randomized-controlled-trial
#5
Mary Jane Esplen, Jiahui Wong, Ellen Warner, Brenda Toner
Purpose This study aimed to test a group psychosocial intervention focused on improving disturbances of body image (BI), sexual functioning, and quality of life in breast cancer (BC) survivors. Methods A prospective, randomized controlled trial was conducted to assess the efficacy of an 8-week group intervention in women after BC treatment. The manual-based intervention combined two powerful ingredients: expressive guided-imagery exercises integrated within a model of group-therapy principles. The intervention facilitates exploration of identity, the development of new self-schemas, and personal growth...
January 22, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29349097/universal-method-for-the-purification-of-recombinant-aav-vectors-of-differing-serotypes
#6
Shelley A Nass, Maryellen A Mattingly, Denise A Woodcock, Brenda L Burnham, Jeffrey A Ardinger, Shayla E Osmond, Amy M Frederick, Abraham Scaria, Seng H Cheng, Catherine R O'Riordan
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To date, most reported purification schemas are serotype dependent, requiring method development for each AAV gene therapy product. Here, we describe a platform purification process that is compatible with the purification of multiple AAV serotypes. The method generates vector preparations of high purity that are enriched for capsids with full vector genomes, and that minimizes the fractional content of empty capsids...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29345037/prevalence-of-cognitive-impairment-in-major-depression-and-bipolar-disorder
#7
Katie M Douglas, Peter Gallagher, Lucy J Robinson, Janet D Carter, Virginia Vw McIntosh, Christopher Ma Frampton, Stuart Watson, Allan H Young, I Nicol Ferrier, Richard J Porter
OBJECTIVES: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response. METHODS: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a mild to moderate depressive episode (unipolar or bipolar), (iii) 56 outpatients with bipolar disorder, in a depressive episode, and (iv) 63 outpatients with bipolar disorder, currently euthymic...
January 18, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29344359/group-schema-therapy-for-eating-disorders-study-protocol
#8
Fiona Calvert, Evelyn Smith, Rob Brockman, Susan Simpson
Background: The treatment of eating disorders is a difficult endeavor, with only a relatively small proportion of clients responding to and completing standard cognitive behavioural therapy (CBT). Given the prevalence of co-morbidity and complex personality traits in this population, Schema Therapy has been identified as a potentially viable treatment option. A case series of Group Schema Therapy for Eating Disorders (ST-E-g) yielded positive findings and the study protocol outlined in this article aims to extend upon these preliminary findings to evaluate group Schema Therapy for eating disorders in a larger sample (n = 40)...
2018: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29325436/patient-predictors-of-response-to-cognitive-behaviour-therapy-and-schema-therapy-for-depression
#9
Janet D Carter, Virginia Vw McIntosh, Jennifer Jordan, Richard J Porter, Katie Douglas, Christopher M Frampton, Peter R Joyce
OBJECTIVE: Few studies have examined differential predictors of response to psychotherapy for depression. Greater understanding about the factors associated with therapeutic response may better enable therapists to optimise response by targeting therapy for the individual. The aim of the current exploratory study was to examine patient characteristics associated with response to cognitive behaviour therapy and schema therapy for depression. METHODS: Participants were 100 outpatients in a clinical trial randomised to either cognitive behaviour therapy or schema therapy...
January 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29282089/evaluation-of-a-software-module-for-adaptive-treatment-planning-and-re-irradiation
#10
Anne Richter, Stefan Weick, Thomas Krieger, Florian Exner, Sonja Kellner, Bülent Polat, Michael Flentje
BACKGROUND: The aim of this work is to validate the Dynamic Planning Module in terms of usability and acceptance in the treatment planning workflow. METHODS: The Dynamic Planning Module was used for decision making whether a plan adaptation was necessary within one course of radiation therapy. The Module was also used for patients scheduled for re-irradiation to estimate the dose in the pretreated region and calculate the accumulated dose to critical organs at risk...
December 28, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29238317/therapeutic-self-disclosure-within-dbt-schema-therapy-and-cbasp-opportunities-and-challenges
#11
Stephan Köhler, Anne Guhn, Felix Betzler, Christian Stiglmayr, Eva-Lotta Brakemeier, Philipp Sterzer
In recent years, various therapeutic interventions have been established that extended behavior and cognitive behavior therapy (CBT) by so-called "third-wave" strategies. In order to address specific therapeutic challenges in certain subgroups of patients who do not sufficiently respond to "classical CBT," some of these third-wave strategies put particular emphasis on therapist self-disclosure. This article highlights therapeutic self-disclosure as a means to address interpersonal problems by comparing three third-wave strategies: (a) acceptance and change strategies as used in Dialectical Behavioral Therapy (DBT), (b) the concept of "limited reparenting" as used in Schema Therapy (ST), and (c) disciplined personal involvement as used in the Cognitive Behavioral Analysis System of Psychotherapy (CBASP)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29222292/uncoding-the-genetic-heterogeneity-of-myelodysplastic-syndrome
#12
REVIEW
R Coleman Lindsley
Myelodysplastic syndrome (MDS) is a clinically heterogeneous disease characterized by functional impairment of hematopoiesis and abnormal bone marrow morphology. The type and severity of hematopoietic dysfunction in MDS are highly variable, and the kinetics of disease progression are difficult to predict. Genomic studies have shown that MDS is typically driven by a multistep somatic genetic process affecting a core set of genes. By definition, recurrent MDS driver mutations all drive clonal dominance, although they can have stereotyped positions in the clonal hierarchy or patterns of comutation association and exclusivity...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222238/clinical-implications-of-somatic-mutations-in-aplastic-anemia-and-myelodysplastic-syndrome-in-genomic-age
#13
REVIEW
Jaroslaw P Maciejewski, Suresh K Balasubramanian
Recent technological advances in genomics have led to the discovery of new somatic mutations and have brought deeper insights into clonal diversity. This discovery has changed not only the understanding of disease mechanisms but also the diagnostics and clinical management of bone marrow failure. The clinical applications of genomics include enhancement of current prognostic schemas, prediction of sensitivity or refractoriness to treatments, and conceptualization and selective application of targeted therapies...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29212570/-teaching-me-to-parent-myself-the-feasibility-of-an-in-patient-group-schema-therapy-programme-for-complex-trauma
#14
Rita Younan, Joan Farrell, Tamara May
BACKGROUND: Group schema therapy is an emerging treatment for personality and other psychiatric disorders. It may be particularly suited to individuals with complex trauma given that early abuse is likely to create maladaptive schemas. AIMS: This pilot study explored the feasibility and effectiveness of a 4-week in-patient group schema therapy programme for adults with complex trauma in a psychiatric hospital setting. METHOD: Thirty-six participants with complex trauma syndrome participated in this open trial...
December 7, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29199818/precision-medicine-in-pediatric-neurooncology-a-review
#15
Aaron Y Mochizuki, Isaura M Frost, Melina B Mastrodimos, Ashley S Plant, Anthony C Wang, Theodore B Moore, Robert M Prins, Paul S Weiss, Steven J Jonas
Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects...
January 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29195073/epigenetic-therapy-ties-myc-depletion-to-reversing-immune-evasion-and-treating-lung-cancer
#16
Michael J Topper, Michelle Vaz, Katherine B Chiappinelli, Christina E DeStefano Shields, Noushin Niknafs, Ray-Whay Chiu Yen, Alyssa Wenzel, Jessica Hicks, Matthew Ballew, Meredith Stone, Phuoc T Tran, Cynthia A Zahnow, Matthew D Hellmann, Valsamo Anagnostou, Pamela L Strissel, Reiner Strick, Victor E Velculescu, Stephen B Baylin
Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune therapy. Herein, pharmacologic and isoform specificity of HDACis are investigated to guide their addition to a DNMTi, thus devising a new, low-dose, sequential regimen that imparts a robust anti-tumor effect for non-small-cell lung cancer (NSCLC). Using in-vitro-treated NSCLC cell lines, we elucidate an interferon α/β-based transcriptional program with accompanying upregulation of antigen presentation machinery, mediated in part through double-stranded RNA (dsRNA) induction...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29171179/optimal-timing-of-viral-load-monitoring-during-pregnancy-to-predict-viraemia-at-delivery-in-hiv-infected-women-initiating-art-in-south-africa-a-simulation-study
#17
Maia Lesosky, Tracy Glass, Elton Mukonda, Nei-Yuan Hsiao, Elaine J Abrams, Landon Myer
INTRODUCTION: HIV viral load (VL) monitoring is a central tool to evaluate ART effectiveness and transmission risk. There is a global movement to expand VL monitoring following recent recommendations from the World Health Organization (WHO), but there has been little research into VL monitoring in pregnant women. We investigated one important question in this area: when and how frequently VL should be monitored in women initiating ART during pregnancy to predict VL at the time of delivery in a simulated South African population...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29149076/the-association-between-food-addiction-and-early-maladaptive-schemas-in-overweight-and-obese-women-a-preliminary-investigation
#18
Claudio Imperatori, Marco Innamorati, David Lester, Massimo Continisio, Michela Balsamo, Aristide Saggino, Mariantonietta Fabbricatore
In recent years, there has been a growing focus on early maladaptive schemas (EMSs) as core features associated with eating psychopathology. The aims of the present study were to assess in overweight and obese women: (i) the association between dysfunctional eating patterns (i.e., food addiction and binge eating) and EMSs, and (ii) the association between food addiction and EMSs after controlling for potential confounding variables (i.e., binge eating severity and psychopathology). Participants were 70 overweight and obese women seeking low-energy-diet therapy...
November 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29125326/young-schema-questionnaire%C3%A2-%C3%A2-short-form-version-3-ysq-s3-preliminary-validation-in-older-adults
#19
Katelyn Phillips, Robert Brockman, Phoebe E Bailey, Ian I Kneebone
OBJECTIVES: The aim of the current study was to establish the reliability and validity of one of the most used schema questionnaires, Young Schema Questionnaire Short Form Version 3 (YSQ-S3) in older adults. METHOD: 104 participants aged 60-84 years were recruited. They were administered a battery of questionnaires, including the YSQ-S3, Young-Atkinson Mode Inventory (YAMI), Germans (Personality) Screener, the Geriatric Depression Scale (GDS), The Geriatric Anxiety Inventory (GAI) and the Basic Psychological Needs Scale (BPNS)...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29120915/schema-therapy-for-emotional-dysregulation-in-personality-disorders-a-review
#20
Harold Dadomo, Marta Panzeri, Daniele Caponcello, Alessandro Carmelita, Alessandro Grecucci
PURPOSE OF REVIEW: To give an update on the most recent studies regarding the role of schema therapy in the treatment of emotion dysregulation related to personality disorders. RECENT FINDINGS: In personality disorders, a lack of emotion regulation can be found. Schema therapy treats emotion dysregulation with a series of techniques, such as imagery rescripting, limited reparenting, chairwork, and cognitive restructuring to remove dysregulatory mechanism. SUMMARY: Schema therapy is one of the most efficient therapies for personality disorders...
November 7, 2017: Current Opinion in Psychiatry
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