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https://www.readbyqxmd.com/read/29792591/comprehensive-evolutionary-and-phylogenetic-analysis-of-hepacivirus-n-hnv
#1
M S da Silva, D M Junqueira, L F Baumbach, S P Cibulski, A C S Mósena, M N Weber, S Silveira, G M de Moraes, R D Maia, V C S Coimbra, C W Canal
Hepaciviruses (HVs) have been detected in several domestic and wild animals and present high genetic diversity. The actual classification divides the genus Hepacivirus into 14 species (A-N), according to their phylogenetic relationships, including the bovine hepacivirus [Hepacivirus N (HNV)]. In this study, we confirmed HNV circulation in Brazil and sequenced the whole genome of two strains. Based on the current classification of HCV, which is divided into genotypes and subtypes, we analysed all available bovine hepacivirus sequences in the GenBank database and proposed an HNV classification...
May 24, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29792034/soft-hydrogel-zwitterionic-coatings-minimize-fibroblast-and-macrophage-adhesion-on-polyimide-substrates
#2
Dusana Trelova, Alice Rita Salgarella, Leonardo Ricotti, Guido Giudetti, Annarita Cutrone, Petra Sramkova, Anna Zahoranova, Dusan Chorvat, Daniel Hasko, Claudio Canale, Silvestro Micera, Juraj Kronek, Arianna Menciassi, Igor Lacik
Minimizing the foreign body reaction to polyimide-based implanted devices has a pivotal role for several biomedical applications. In this work we propose materials exhibiting non-biofouling properties and a Young's modulus reflecting the one of soft human tissues. We describe the synthesis, characterization and in vitro validation of poly(carboxybetaine) hydrogel coatings covalently attached to polyimide substrates via a photolabile 4-azidophenyl group, incorporated in poly(carboxybetaine) chains at two concentrations of 1...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29792021/evaluation-of-tooth-discolouration-after-the-use-of-experimental-medication-as-root-canal-dressings-an-in-vitro-study
#3
Lorena O Mendes, Nathália E Machado, Paulo R Goldoni, Graziela G Mori
BACKGROUND: Endodontic infections require the use of root canal dressings to reduce microorganisms, and studies of new intracanal medications are common. Two experimental intracanal medications that contain antibiotics and chlorhexidine have been proposed. However, given the composition of these medications, tooth discolouration with subsequent impacts on aesthetic parameters is a concern. The objective of this study is to evaluate tooth discolouration after the use of experimental intracanal medications for up to 180 days...
May 23, 2018: Minerva Stomatologica
https://www.readbyqxmd.com/read/29791974/isolation-and-identification-of-vibrio-species-in-the-rio-bravo-grande-and-water-bodies-from-reynosa-tamaulipas
#4
I Guardiola-Avila, V Martínez-Vázquez, R Requena-Castro, K Juárez-Rendón, M G Aguilera-Arreola, G Rivera, V Bocanegra-García
The Rio Bravo (Rio Grande) adjoins various states in the Mexican region and has a great importance in water distribution in the northeast Tamaulipas (Mexico). In this work 161 strains were isolated, identified and characterized from the water samples taken from the flow of the Rio Bravo and the two inner canals that cover Reynosa city. The strains were identified as V. cholerae (74.5%), Vibrio spp. (1.2%) and V. mimicus (0.6%). Furthermore, the detected virulence genes in the V. cholerae strains, were the hlyA, ompU, tcpA, toxR genes in 78...
May 23, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29791702/all-inside-technique-for-acl-reconstruction-using-a-flipcutter%C3%A2-and-the-tightrope%C3%A2-system
#5
Nicos Papaloucas
There have been many innovations in the field of ACL-reconstruction over the years, including the FlipCutter® and TightRope® system (both from Arthrex Inc.). The FlipCutter® is a combined guide pin and reamer that allows minimally invasive socket-creation from the inside out, especially in difficult-to-reach areas. The TightRope® is a further development of the well-known Endobutton™ (Smith & Nephew plc) that consists of a four-point knotless locking system. Its main advantage is its adjustability, which makes it possible to fill the entire bone socket with the graft without any empty space...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791567/immunohistological-study-of-the-effect-of-vascular-endothelial-growth-factor-on-the-angiogenesis-of-mature-root-canals-in-rat-molars
#6
Cleber Keiti Nabeshima, José Edgar Valdivia, Hector Caballero-Flores, Victor Elias Arana-Chavez, Manoel Eduardo de Lima Machado
Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods Upper first molars of twelve 13-week old Wistar male rats were used. The root pulp of the mesiobuccal canal was removed and the root canal instrumented with K-files up to size #25. Periapical bleeding was induced into the root canal by introducing a #15 K-file beyond the apex...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29791425/-endoscopic-submucosal-dissection-of-a-transpyloric-early-gastric-c%C3%A3-ncer-a-case-report-and-literature-review
#7
Juan Antonio Chirinos Vega, César García Delgado, Alfonso Delgado Vergara
The endoscopic sumucosal disection (ESD) is an advanced endoscopic technique that achieves the curative resection of superficial neoplasms of the gastrointestinal tract, getting block exeresis with margins free of neoplasia avoiding surgery. However, tumors located in the esophagogastric junction, or pylorus, are technically more complex to resect by ESD. When a neoplasm settles in the pylorus, the anatomical characteristics of this region can affect the adequate assessment of the margins and the performance of the procedure...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29791199/localization-of-the-inferior-alveolar-canal-using-ultralow-dose-ct-with-iterative-reconstruction-techniques
#8
Asma'a Abdulrahman Al-Ekrish, Wafa Alfaleh, Romed Hörmann, Ameera Alabdulwahid, Wolfgang Puelacher, Gerlig Widmann
OBJECTIVES: To compare subjective and objective localization of the inferior alveolar canal (IAC) on multidetector computed tomography (MDCT) images obtained by ultralow doses in combination with the reconstruction techniques of filtered backprojection (FBP), Adaptive Statistical Iterative Reconstruction (ASIR), or Model Based Iterative Reconstruction (MBIR) as compared to standard dose MDCT and FBP. METHODS: Three cadavers were imaged with a reference standard dose MDCT examination (CTDIvol: 29...
May 23, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29790970/balloon-occlusion-testing-to-assess-retinal-collateral-and-predict-visual-outcomes-in-the-management-of-a-fusiform-intraorbital-ophthalmic-artery-aneurysm-technical-note-and-literature-review
#9
Mithun G Sattur, Matthew E Welz, Bernard R Bendok, Jeffrey W Miller
BACKGROUND AND IMPORTANCE: Aneurysms of the ophthalmic artery (OA) within the orbit and optic canal are extremely rare. Given the peripheral location of these aneurysms and the fact that most are fusiform, parent artery occlusion is preferred for symptomatic aneurysms. However, the impact of OA occlusion on vision is not always innocuous. Balloon occlusion testing (BOT) of the OA has the potential to gauge the possibility of visual compromise, in addition to assessing collaterals. While BOT has been assessed for carotid artery occlusion, its role in OA occlusion has not been well defined...
May 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29790567/regional-diversity-in-the-murine-cortical-vascular-network-is-revealed-by-synchrotron-x-ray-tomography-and-is-amplified-with-age
#10
J A Núñez, A Goring, B Javaheri, H Razi, D Gomez-Nicola, A A Pitsillides, P J Thurner, D Gomez-Nicola, P Schneider, C E Clarkin
TCortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood supply to the bone could enhance the understanding of bone strength determinants and fracture healing. Using synchrotron radiation-based computed tomography, the distribution of vascular canals and osteocyte lacunae was assessed in murine cortical bone and the influence of age on these parameters was investigated...
May 23, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29789864/-vascularized-tumor-of-the-retroauricular-skin
#11
P Meister, W Kelker, U Gößler, R Hammerstingl, T J Vogl, R Winkelmann
An 84-year-old female patient with loss of hearing and otorrhoea went to an otolaryngologist. On examination, a polypoid mass in the auditory canal and a retroauricular skin lesion, possibly seborrheic keratosis, were found. Only the skin was submitted for histological examination and showed a cutaneous highly vascular lesion with an associated "zellballen" of clear cells without atypia. The initial diagnosis was that of a cutaneous glomangioma. Immunohistochemical findings favored diagnosis of a paraganglioma...
May 22, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29789790/distinct-epitopes-on-cd13-mediate-opposite-consequences-for-cell-adhesion
#12
Claudia A Garay-Canales, Ileana Licona-Limón, Enrique Ortega
CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metastasis. CD13 has also been proposed to participate in cell adhesion, as crosslinking of CD13 by certain CD13-specific antibodies induces homotypic aggregation of monocytes and heterotypic adhesion of monocytes to endothelial cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789216/the-clinical-presentation-and-collateral-pathway-development-of-congenital-absence-of-the-internal-carotid-artery
#13
Peng Zhang, Zheng Wang, Feng-Xia Yu, Han Lv, Xue-Huan Liu, Wei-Hua Feng, Jun Ma, Zheng-Han Yang, Zhen-Chang Wang
OBJECTIVE: The objective of this study was to investigate the clinical presentation, risks, and collateral pathway development of the congenital absence of the internal carotid artery (ICA). METHODS: Sixty-four patients (10 new patients and 54 patients from the relevant literature) were studied. Data on demographic, clinical, and radiologic features were collected, followed by an analysis of the risks associated with ICA agenesis. RESULTS: There were 31 male and 33 female patients whose ages ranged from 5 months to 75 years, with a mean age of 31...
May 19, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29788991/bilateral-tympanokeratomas-cholesteatomas-with-bilateral-otitis-media-unilateral-otitis-interna-and-acoustic-neuritis-in-a-dog
#14
Liv Østevik, Kathrine Rudlang, Tuva Holt Jahr, Mette Valheim, Bradley Lyndon Njaa
BACKGROUND: An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis and perineuritis in a dog with chronic otitis, bilateral tympanokeratomas and presumed extension of otic infection to the central nervous system...
May 22, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29788831/lumbosacral-transitional-vertebrae-in-cats-and-its-relationship-to-lumbosacral-vertebral-canal-stenosis
#15
Georgina Harris, Jessica Ball, Steven De Decker
Objectives Although a clear relationship has been demonstrated between the presence of lumbosacral transitional vertebrae and the development of lumbosacral stenosis in dogs, this relationship has not been evaluated in cats. The aim of this study was to investigate the relationship between the presence of lumbosacral transitional vertebrae and lumbosacral stenosis in cats. Methods The medical records and diagnostic imaging studies of 13 cats diagnosed with lumbosacral stenosis were retrospectively reviewed for lumbosacral abnormalities and compared with findings of 405 cats that underwent CT for reasons unrelated to spinal disease...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29788544/cochlear-implantation-using-a-custom-guide-catheter-in-fourteen-patients-with-incomplete-partition-type-iii
#16
Hao Tian, Line Wang, Fenqi Gao, Wenqi Liang, Kevin A Peng
Incomplete partition type III (IP-III), also termed X-linked deafness with stapes gusher, is a heterogeneous condition that predominantly affects males; however, females demonstrating the phenotype also exist. The absence of a bony partition between the fundus of the internal auditory canal (IAC) and cochlea predisposes these patients to cerebrospinal fluid leak or electrode passage into the IAC when performing cochlear implantation. We describe a surgeon-fabricated guide catheter, made intraoperatively from a 16-gauge intravenous catheter, that helps avoid electrode passage into the IAC during CI for patients with IP-III...
May 22, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29788439/repair-of-temporal-bone-defects-via-the-middle-cranial-fossa-approach-treatment-of-2-pathologies-with-1-operation
#17
Daniel B Eddelman, Stephan Munich, Ryan B Kochanski, Michael Eggerstedt, Robert P Kazan, Roham Moftakhar, Lorenzo Munoz, Rich W Byrne, R Mark Wiet
BACKGROUND: Temporal bone dehiscence (TBD) often results in leakage of cerebrospinal fluid (CSF) and/or encephalocele. TBD can also occur over the superior semicircular canal, causing debilitating vertigo. Both can be repaired surgically, but traditional treatment is focused only on one pathology, not both. OBJECTIVE: To report our experience in the treatment of TBD via the middle cranial fossa (MCF) approach. METHODS: A retrospective review was conducted for all patients who underwent MCF approach for surgical repair of any temporal fossa dehiscence...
May 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29788370/large-traumatic-skull-base-internal-carotid-artery-pseudoaneurysm-managed-with-endovascular-flow-diversion-2-dimensional-operative-video
#18
Gary Rajah, Richard Justin Garling, Leonardo Rangel-Castilla
We present a case of a traumatic skull base internal carotid artery (ICA) pseudoaneurysm treated with endovascular flow diversion stenting. The patient was a 27-year-old male who was involved in a motorcycle accident suffering multiple traumatic injuries including a large skull base fracture that extended through the carotid canal. Computed tomography angiography revealed a 2-cm right ICA pseudoaneurysm. Once the patient was stable, a digital subtraction angiography demonstrated enlargement of the pseudoaneurysm...
May 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29787862/multiple-modes-of-canalization-links-between-genetic-environmental-canalizations-and-developmental-stability-and-their-trait-specificity
#19
REVIEW
Kazuo H Takahashi
The robustness of biological systems against mutational and environmental perturbations is termed canalization. Because reducing phenotypic variability under environmental and genetic perturbations can be adaptive and facilitated by natural selection, it has been suggested that once canalization mechanisms have evolved to buffer the effects of environmental perturbations, they may act to buffer any and all sources of variation. Although whether canalization mechanisms are general or specific to the types of perturbation or phenotypic traits that they buffer is often addressed, the links between different canalization mechanisms remain unclear...
May 19, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29787861/morphological-homeostasis-in-the-fossil-record
#20
REVIEW
Mark Webster
Morphological homeostasis limits the extent to which genetic and/or environmental variation is translated into phenotypic variation, providing generation-to-generation fitness advantage under a stabilizing selection regime. Depending on its lability, morphological homeostasis might also have a longer-term impact on evolution by restricting the variation-and thus the response to directional selection-of a trait. The fossil record offers an inviting opportunity to investigate whether and how morphological homeostasis constrained trait evolution in lineages or clades on long timescales (thousands to millions of years) that are not accessible to neontological studies...
May 19, 2018: Seminars in Cell & Developmental Biology
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