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https://www.readbyqxmd.com/read/28934804/comparison-of-7-surgical-interventions-for-lumbar-disc-herniation-a-network-meta-analysis
#1
Fan Feng, Qianqian Xu, Feifei Yan, Yuanlong Xie, Zhouming Deng, Chao Hu, Xiaobin Zhu, Lin Cai
BACKGROUND: The number of interventions on intervertebral discs rapidly increased and the treatment options for lumbar disc surgery quickly evolved. It is important that the safety and efficacy of all new innovative procedures be compared with currently accepted forms of treatment; however, the previous pairwise meta-analyses could not develop the hierarchy of these treatments. OBJECTIVES: The purpose of the study is to perform a network meta-analysis to evaluate the clinical results of 7 surgical interventions for the treatment of lumbar disc herniation...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934794/effects-of-epidemiological-factors-and-pressure-pain-measurements-in-predicting-postoperative-pain-a-prospective-survey-of-1-002-chinese-patients
#2
Guangyou Duan, Shanna Guo, Yuhao Zhang, Ying Ying, Penghao Huang, Li Zhang, Xianwei Zhang
BACKGROUND: A high degree of inter-individual differences was noted in human basal pain as well as the reporting of clinical pain, such as postoperative pain. Understanding the effects of common epidemiological variations and preoperative experimental methods of human pain perception may contribute to individualized pain treatment for patients. OBJECTIVES: The current study was aimed to assess the role of epidemiological factors and preoperative experimental pain sensitivity for predicting postoperative pain and to analyze the potential effects of epidemiological factors on experimental pain sensitivity...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934787/complex-regional-pain-syndrome-type-i-a-debilitating-and-poorly-understood-syndrome-possible-role-for-pulsed-electromagnetic-fields-a-narrative-review
#3
Stefania Pagani, Francesca Veronesi, Nicolo Nicoli Aldini, Milena Fini
BACKGROUND: Complex regional pain syndrome type I (CRPS-I), also called algodystrophy, is a complex syndrome characterized by limb pain, edema, allodynia, hyperalgesia and functional impairment of bone with a similar clinical picture of osteoporosis, including an increased release of various pro-inflammatory neuropeptides and cytokines. Several treatments have been proposed for CRPS-I, but due to the poor outcome of conventional drugs and the invasiveness of some techniques, expectations are now directed towards new resources that could be more effective and less invasive...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934785/1-year-results-of-a-randomized-controlled-trial-of-conservative-management-vs-minimally-invasive-surgical-treatment-for-sacroiliac-joint-pain
#4
Julius Dengler Dengler, Djaya Kools, Robert Pflugmacher, Alessandro Gasbarrini, Domenico Prestamburgo, Paolo Gaetani, Eddie van Eeckhoven, Daniel Cher, Bengt Sturesson
BACKGROUND: Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. Devices to fuse the SIJ are now commercially available, but high-quality evidence supporting their effectiveness is limited. OBJECTIVES: To compare the safety and effectiveness of conservative management (CM) to minimally invasive sacroiliac joint fusion (SIJF) in patients with chronic LBP originating from the SIJ. STUDY DESIGN: Prospective, multicenter randomized controlled trial...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934615/working-memory-and-prefrontal-temporal-hemodynamic-responses-during-post-task-period-in-patients-with-schizophrenia-a%C3%A2-multi-channel-near-infrared-spectroscopy-study
#5
Takamasa Noda, Kazuyuki Nakagome, Shiori Setoyama, Eisuke Matsushima
The relationship between cognitive impairments and social dysfunction in schizophrenia is widely accepted. Neuroimaging studies in patients with schizophrenia have demonstrated abnormal function in the prefrontal region during various neurocognitive tasks. However, studies exploring the neural basis of these cognitive impairments are still limited. Multi-channel near-infrared spectroscopy (NIRS) is a non-invasive functional neuroimaging technique used to detect the spatiotemporal characteristics of brain activity...
September 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28934599/rewarming-after-severe-accidental-hypothermia-using-the-esophageal-heat-transfer-device-a-case-report
#6
Katarina Katja Primožič, Franci Svenšek, Andrej Markota, Andreja Sinkovič
Patients with severe accidental hypothermia require active rewarming. External rewarming may not be successful in severe hypothermia, and use of invasive techniques is limited to regional centers and is associated with vascular access site and other complications. We present a patient with severe accidental hypothermia who was successfuly rewarmed using a novel esophageal heat transfer device. A 55-year-old male (175 cm, 71 kg) was admitted with the first recorded temperature 23.3°C. Rewarming using renal replacement therapy circuit was unsuccessful because of severe hypotension...
September 21, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28934419/characterizing-antigenic-determinants-in-helicobacter-pylori-caga-capable-of-detecting-serum-antibodies-in-children
#7
Min-Kyoung Shin, Jin-Su Jun, Soon-Wook Kwon, Dong-Hae Lee, Jong-Hun Ha, Jin-Sik Park, Hyung Lyun Kang, Seung Chul Baik, Ji Sook Park, Ji-Hyun Seo, Hee-Shang Youn, Myung Je Cho, Woo Kon Lee
Helicobacter pylori can persistently colonize the mucosa of the human stomach, resulting in gastric disorders. Endoscopic biopsy for rapid urease test and histopathologic examination are considered as the most accurate diagnostic methods for H. pylori infection. Serological methods are recommended for children because of invasiveness of the diagnosis mentioned above. Here, the cytotoxin-associated gene A protein (Cag A), as an immunodominant antigen, was subdivided to determine which regions harbor antigenicity for humans...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28934365/murine-glomerular-transcriptome-links-endothelial-cell-specific-molecule-1-deficiency-with-susceptibility-to-diabetic-nephropathy
#8
Xiaoyi Zheng, Fariborz Soroush, Jin Long, Evan T Hall, Puneeth K Adishesha, Sanchita Bhattacharya, Mohammad F Kiani, Vivek Bhalla
Diabetic nephropathy (DN) is the leading cause of kidney disease; however, there are no early biomarkers and no cure. Thus, there is a large unmet need to predict which individuals will develop nephropathy and to understand the molecular mechanisms that govern this susceptibility. We compared the glomerular transcriptome from mice with distinct susceptibilities to DN at four weeks after induction of diabetes, but before histologic injury, and identified differential regulation of genes that modulate inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28934317/photosynthetic-epibionts-and-endobionts-of-pacific-oyster-shells-from-oyster-reefs-in-rocky-versus-mudflat-shores
#9
Laurent Barillé, Anthony Le Bris, Vona Méléder, Patrick Launeau, Marc Robin, Ioanna Louvrou, Lourenço Ribeiro
The Pacific oyster, Crassostrea gigas (Thunberg), is the main bivalve species cultivated in the world. With global warming enabling its reproduction and larval survival at higher latitudes, this species is now recognized as invasive and creates wild oyster reefs globally. In this study, the spatial distribution of photosynthetic assemblages colonizing the shells of wild C. gigas was investigated on both a large scale (two contrasting types of reefs found in mudflats and rocky areas) and a small scale (within individual shells) using a hyperspectral imager...
2017: PloS One
https://www.readbyqxmd.com/read/28934315/usefulness-of-fecal-calprotectin-for-the-early-prediction-of-short-term-outcomes-of-remission-induction-treatments-in-ulcerative-colitis-in-comparison-with-two-item-patient-reported-outcome
#10
Takahiko Toyonaga, Taku Kobayashi, Masaru Nakano, Eiko Saito, Satoko Umeda, Shinji Okabayashi, Ryo Ozaki, Toshifumi Hibi
BACKGROUND: Fecal calprotectin (FC) is well accepted as a non-invasive biomarker which objectively reflects colonic inflammation in ulcerative colitis (UC). However, its value as a marker of response during the early phase of remission induction treatment has not been well studied. The aim of this study is to evaluate the significance of FC for predicting the short-term outcomes of remission induction treatment in patients with UC. METHODS: A prospective observational study was conducted among 31 patients with active UC...
2017: PloS One
https://www.readbyqxmd.com/read/28934299/a-novel-copro-diagnostic-molecular-method-for-qualitative-detection-and-identification-of-parasitic-nematodes-in-amphibians-and-reptiles
#11
Lucas G Huggins, Christopher J Michaels, Sheena M Cruickshank, Richard F Preziosi, Kathryn J Else
Anthropogenic disturbance via resource acquisition, habitat fragmentation and climate change, amongst other factors, has led to catastrophic global biodiversity losses and species extinctions at an accelerating rate. Amphibians are currently one of the worst affected classes with at least a third of species categorised as being threatened with extinction. At the same time, they are also critically important for many habitats and provide man with a powerful proxy for ecosystem health by acting as a bioindicator group...
2017: PloS One
https://www.readbyqxmd.com/read/28934283/grading-of-invasive-breast-carcinoma-through-grassmannian-vlad-encoding
#12
Kosmas Dimitropoulos, Panagiotis Barmpoutis, Christina Zioga, Athanasios Kamas, Kalliopi Patsiaoura, Nikos Grammalidis
In this paper we address the problem of automated grading of invasive breast carcinoma through the encoding of histological images as VLAD (Vector of Locally Aggregated Descriptors) representations on the Grassmann manifold. The proposed method considers each image as a set of multidimensional spatially-evolving signals that can be efficiently modeled through a higher-order linear dynamical systems analysis. Subsequently, each H&E (Hematoxylin and Eosin) stained breast cancer histological image is represented as a cloud of points on the Grassmann manifold, while a vector representation approach is applied aiming to aggregate the Grassmannian points based on a locality criterion on the manifold...
2017: PloS One
https://www.readbyqxmd.com/read/28934275/activation-of-phosphatidylinositol-3-kinase-akt-snail-signaling-pathway-contributes-to-epithelial-mesenchymal-transition-induced-multi-drug-resistance-to-sorafenib-in-hepatocellular-carcinoma-cells
#13
Jiejie Dong, Bo Zhai, Weihua Sun, Fengli Hu, Hao Cheng, Jun Xu
Sorafenib, an orally available kinase inhibitor, is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), and it exerts potent inhibitory activity against epithelial-mesenchymal transition (EMT) and multidrug resistance (MDR) by inhibiting mitogen-activated protein kinase (MAPK) signaling in HCC. However, after long-term exposure to sorafenib, HCC cells exhibit EMT and resistance to sorafenib. The activation of AKT by sorafenib is thought to be responsible for the development of these characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28934233/cardiovascular-disease-and-mortality-after-breast-cancer-in-postmenopausal-women-results-from-the-women-s-health-initiative
#14
Na-Jin Park, Yuefang Chang, Catherine Bender, Yvette Conley, Rowan T Chlebowski, G J van Londen, Randi Foraker, Sylvia Wassertheil-Smoller, Marcia L Stefanick, Lewis H Kuller
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among older postmenopausal women. The impact of postmenopausal breast cancer on CVD for older women is uncertain. We hypothesized that older postmenopausal women with breast cancer would be at a higher risk of CVD than similar aged women without breast cancer and that CVD would be a major contributor to the subsequent morbidity and mortality. METHODS: In a prospective Women's Health Initiative study, incident CVD events and total and cause-specific death rates were compared between postmenopausal women with (n = 4,340) and without (n = 97,576) incident invasive breast cancer over 10 years post-diagnosis, stratified by 3 age groups (50-59, 60-69, and 70-79)...
2017: PloS One
https://www.readbyqxmd.com/read/28934230/e-cadherin-a-determinant-molecule-associated-with-ovarian-cancer-progression-dissemination-and-aggressiveness
#15
Marina Rosso, Blanca Majem, Laura Devis, Lara Lapyckyj, María José Besso, Marta Llauradó, María Florencia Abascal, María Laura Matos, Lucia Lanau, Josep Castellví, José Luis Sánchez, Asunción Pérez Benavente, Antonio Gil-Moreno, Jaume Reventós, Anna Santamaria Margalef, Marina Rigau, Mónica Hebe Vazquez-Levin
Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern. Epithelial-to-mesenchymal transition (EMT) has been reported in OC and downregulation of Epithelial cadherin (E-cadherin) is a hallmark of this process. However, findings on the relationship between E-cadherin levels and OC progression, dissemination and aggressiveness are controversial. In this study, the evaluation of E-cadherin expression in an OC tissue microarray revealed its prognostic value to discriminate between advanced- and early-stage tumors, as well as serous tumors from other histologies...
2017: PloS One
https://www.readbyqxmd.com/read/28934151/natural-history-of-hpv-infection-across-the-lifespan-role-of-viral-latency
#16
REVIEW
Patti E Gravitt, Rachel L Winer
Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection)...
September 21, 2017: Viruses
https://www.readbyqxmd.com/read/28934140/applications-of-pna-based-artificial-restriction-dna-cutters
#17
REVIEW
Narumi Shigi, Jun Sumaoka, Makoto Komiyama
More than ten years ago, artificial restriction DNA cutters were developed by combining two pseudo-complementary peptide nucleic acid (pcPNA) strands with either Ce(IV)/EDTA or S1 nuclease. They have remarkably high site-specificity and can cut only one predetermined site in the human genome. In this article, recent progress of these man-made tools have been reviewed. By cutting the human genome site-selectively, desired fragments can be clipped from either the termini of chromosomes (telomeres) or from the middle of genome...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28934122/invasion-of-dendritic-cells-macrophages-and-neutrophils-by-the-bordetella-adenylate-cyclase-toxin-a-subversive-move-to-fool-host-immunity
#18
REVIEW
Giorgio Fedele, Ilaria Schiavoni, Irena Adkins, Nela Klimova, Peter Sebo
Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host's respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3',5'-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28934061/current-safety-issues-with-quadrivalent-meningococcal-conjugate-vaccines
#19
Tanya R Myers, Michael M McNeil
Invasive meningococcal disease, although rare, can present as sudden, life-threatening disease with high risk of mortality or severe long-term sequelae. The main prevention strategy for invasive meningococcal disease in the United States is the routine vaccination of adolescents and other persons at increased risk of meningococcal disease with quadrivalent meningococcal conjugate vaccines. Two such vaccines are currently licensed and available in the United States, Menactra® (Sanofi Pasteur) and Menveo® (Glaxo Smith Kline), and usage in the adolescent population have steadily increased since their introduction...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28934010/down-regulation-of-klf5-in-cancer-associated-fibroblasts-inhibit-gastric-cancer-cells-progression-by-ccl5-ccr5-axis
#20
Tingsong Yang, Min Chen, Yingying Sun, Xiaobing Zhang, Zhou Zhang, Bin Xu, Jie Hua, Zhigang He, Zhenshun Song
It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal fibroblasts activation and tumor promoting effects remain unclear. Here, we showed that KLF5 expression was more frequently observed in gastric cancer-associated fibroblasts compared with normal mucosal fibroblasts. Moreover, KLF5 expression in tumor stroma was closely associated with clinicopathological features such as tumor size, invasion depth, cell grade and lymph node metastasis, as well as poor prognosis in patients with gastric cancer...
September 21, 2017: Cancer Biology & Therapy
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