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https://www.readbyqxmd.com/read/29166703/in-hospital-outcomes-in-invasively-managed-acute-myocardial-infarction-patients-who-receive-morphine
#1
Cian P McCarthy, Vijeta Bhambhani, Eugene Pomerantsev, Jason H Wasfy
OBJECTIVE: We aimed to analyze the association between morphine and in-hospital outcomes in invasively managed ST elevation myocardial infarction (STEMI) and non-ST elevation acute coronary syndrome (NSTE-ACS) patients. BACKGROUND: Morphine is commonly used for analgesia in the setting of acute coronary syndromes (ACS); however, recently its utility in ACS has come under closer scrutiny. METHODS: We identified all STEMI and NSTE-ACS patients undergoing coronary angiogram +/- percutaneous intervention between January 2009 and July 2016 in our center and recorded patient characteristics and inpatient outcomes...
November 22, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29166698/-the-value-of-endoscopic-decompression-in-surgical-therapy-of-carpal-tunnel-syndrome
#2
Maximilian E T Hessenauer, Andreas Arkudas, Ingo Ludoph, Elias Polykandriotis, Raymund E Horch
Carpal tunnel syndrome is one of the most common diseases in hand surgery. The gold standard in therapy is the surgical release of the carpal tunnel. We provide a brief update on the relevant pathogenesis, diagnosis and therapy and discuss questions related to minimal invasive decompression of the median nerve. Together with a review of the current literature, we report on our experiences in minimally invasive carpal tunnel release via a monoportal endoscopic access in over 700 cases. In conclusion, the endoscopic technique provides superior convalescence and patient safety is comparable to open methods...
November 22, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29166696/-fluorescence-cholangiography-in-comparison-to-radiographic-cholangiography-during-laparoscopic-cholecystectomy
#3
Viktoria Pax, Sylke Schneider-Koriath, Martin Scholz, Reiko Wießner, Kaja Ludwig
Background The reported incidence rate of bile duct injury (BDI) during laparoscopic cholecystectomy (LC) is 0.3%. However, routine use of intraoperative cholangiography (IOC) is a controversial, due to the additional cost and radiation exposure. The aim of this study was to assess the application of fluorescence cholangiography (FC) in comparison to IOC and to LC without any intraoperative imaging. Materials and Methods This prospective study included 230 patients undergoing LC in our institution. The subjects were divided into two groups...
November 22, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29166639/apobec3a-expression-in-penile-squamous-cell-carcinoma
#4
Martina Heller, Elena-Sophie Prigge, Adam Kaczorowski, Magnus von Knebel Doeberitz, Markus Hohenfellner, Stefan Duensing
BACKGROUND: APOBECs (apolipoprotein B mRNA-editing catalytic polypeptides) are cytidine deaminases that have been implicated in the host defense against viruses by blocking viral replication. They have also been shown to play a role in genome hypermutation in several human cancers. An APOBEC3 hypermutation signature has been discovered in cervical cancer, which is intimately associated with infection by high-risk human papillomaviruses (HPVs). At the same time, HPV genomes themselves are subject to DNA editing by APOBECs...
November 23, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29166285/an-evaluation-of-the-usefulness-of-invasive-and-non-invasive-methods-used-to-diagnose-helicobacter-spp-infections-in-dogs
#5
M Jankowski, J Spużak, K Kubiak, K Glińska-Suchocka, M Biernat
The aim of this study was to assess the suitability of invasive and non-invasive methods used to diagnose Helicobacter spp. in the stomachs of dogs. The study was carried out on 30 dogs of both sexes and different breeds, between one and 15 years old. A histopathologic examination, a microbiological culture, a rapid urease test, a direct bacteriological preparation and a nested PCR assay were carried out. Gastric Helicobacter spp. was identified in gastric biopsy specimens from 16 (53.3%) dogs using direct bacteriological preparation, in four (13...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166274/detection-of-experimental-swine-trichinellosis-using-commercial-elisa-test
#6
Michal Gondek, J Bień, Z Nowakowski
The aim of the study carried out on ten young (10-week old) pigs of the native Polish Large White breed experimentally infected with a low dose of 300 invasive muscle larvae (ML) of Trichinella spiralis was intravital detection of trichinellosis using the E-S ELISA test, determination of a variation level of IgG antibodies against excretory-secretory (E-S) antigens of T. spiralis muscle larvae and finally, describing the intensity of T. spiralis larvae infection in selected muscles. The pig sera were collected at 7 and 9 days prior to the experimental infection with T...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166201/warm-water-compress-as-an-alternative-for-decreasing-the-degree-of-phlebitis
#7
Fitri Annisa, Nani Nurhaeni, Dessie Wanda
Intravenous fluid therapy is an invasive procedure which may increase the risk of patient complications. One of the most common of these is phlebitis, which may cause discomfort and tissue damage. Therefore, a nursing intervention is needed to effectively treat phlebitis. The purpose of this study was to investigate the effectiveness of applying a warm compression intervention to reduce the degree of phlebitis. A quasi-experimental pre-test and post-test design was used, with a non-equivalent control group...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166199/differences-in-temperature-changes-in-premature-infants-during-invasive-procedures-in-incubators-and-radiant-warmers
#8
Ludwy Handhayanti, Yeni Rustina, Tri Budiati
Premature infants tend to lose heat quickly. This loss can be aggravated when they have received an invasive procedure involving a venous puncture. This research uses crossover design by conducting 2 intervention tests to compare 2 different treatments on the same sample. This research involved 2 groups with 18 premature infants in each. The process of data analysis used a statistical independent t test. Interventions conducted in an open incubator showed a p value of .001 which statistically related to heat loss in premature infants...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166181/sensitivity-specificity-and-accuracy-of-kramer-examination-of-neonatal-jaundice-comparison-with-total-bilirubin-serum
#9
Zesi Aprillia, Dewi Gayatri, Fajar Tri Waluyanti
Neonatal jaundice often occurs in the first week after birth. Early detection of neonatal jaundice can prevent kernicterus as a complication of high levels of bilirubin in neonates. Visual assessment is one of the examinations introduced by Kramer to assess the presence of neonatal jaundice. The purpose of this study was to determine the sensitivity, specificity, and accuracy of Kramer's visual assessment in the examination of neonatal jaundice. This study used cross-sectional design to examine 102 infants, with the sample selected by the convenience sampling method...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166033/mapping-nanoscale-hotspots-with-single-molecule-emitters-assembled-into-plasmonic-nanocavities-using-dna-origami
#10
Rohit Chikkaraddy, V A Turek, Nuttawut Kongsuwan, Felix Benz, Cloudy Carnegie, Tim Van De Goor, Bart de Nijs, Angela Demetriadou, Ortwin Hess, Ulrich F Keyser, Jeremy J Baumberg
Fabricating nanocavities in which optically-active single quantum emitters are precisely positioned, is crucial for building nanophotonic devices. Here we show that self-assembly based on robust DNA-origami constructs can precisely position single molecules laterally within sub-5nm gaps between plasmonic substrates that support intense optical confinement. By placing single-molecules at the center of a nanocavity, we show modulation of the plasmon cavity resonance before and after bleaching the chromophore, and obtain enhancements of ≥ 4×10(3) with high quantum yield (≥ 50%)...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29165888/molecular-pathology-and-thyroid-fna
#11
REVIEW
D N Poller, S Glaysher
This review summarises molecular pathological techniques applicable to thyroid FNA. The molecular pathology of thyroid tumours is now fairly well understood. Molecular methods may be used as a rule-in test for diagnosis of malignancy in thyroid nodules, eg BRAF V600E point mutation, use of a seven-gene mutational panel (BRAF V600E, RAS genes, RET/PTC or PAX8/PPARG rearrangement), or as a comprehensive multigene next-generation sequencing panel, eg ThyroSeq v2. Molecular methods can also be applied as rule-out tests for malignancy in thyroid nodules, eg Afirma or ThyroSeq v2 or as markers of prognosis, eg TERT promoter mutation or other gene mutations including BRAF V600E, TP53 and AKT1, and as tests for newly defined tumour entities such as non-invasive follicular thyroid neoplasm with papillary like nuclei, or as a molecular marker(s) for targeted therapies...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29165886/pre-operative-features-of-non-invasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-an-analysis-of-their-cytological-gene-expression-classifier-and-sonographic-findings
#12
S J Song, V A LiVolsi, K Montone, Z Baloch
OBJECTIVE: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology. METHODS: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1(st) April 2016 and 1(st) April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29165847/breast-lesion-characterization-using-whole-lesion-histogram-analysis-with-stretched-exponential-diffusion-model
#13
Chunling Liu, Kun Wang, Xiaodan Li, Jine Zhang, Jie Ding, Karl Spuhler, Timothy Duong, Changhong Liang, Chuan Huang
BACKGROUND: Diffusion-weighted imaging (DWI) has been studied in breast imaging and can provide more information about diffusion, perfusion and other physiological interests than standard pulse sequences. The stretched-exponential model has previously been shown to be more reliable than conventional DWI techniques, but different diagnostic sensitivities were found from study to study. PURPOSE: This work investigated the characteristics of whole-lesion histogram parameters derived from the stretched-exponential diffusion model for benign and malignant breast lesions, compared them with conventional apparent diffusion coefficient (ADC), and further determined which histogram metrics can be best used to differentiate malignant from benign lesions...
November 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29165776/model-driven-gas-exchange-monitoring-in-the-critically-ill
#14
Cosmin Ion Balan, Adrian View-Kim Wong
Understanding pulmonary gas exchange performance is a dynamic process which, depending on clinical context, exhibits different levels of complexity. Global tools such as tension-based indexes yield clinically crucial information under very specific conditions. Yet, accurate mechanistic insight can only originate in model-based tools. One-parameter models such as shunt or dead space are well established in clinical practice whilst two or three-parameter models have just been advanced and their role is yet to be delineated...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29165772/pediatric-protein-metabolism-techniques-a-review
#15
G Liu, Z-G Li, H-W Wu
Some invasive techniques could be safely and ethically applied to estimate protein metabolism in children. Although these methodologies provide valuable information on whole body protein metabolism, a reflection of what is happening to thousands of protein molecules across a variety of different tissues. However, they provide little information regarding the contribution of specific tissues and proteins to the whole-body changes observed (e.g., whether the increase in protein synthesis was a result of the muscle or splanchnic tissues) which might otherwise be determined in more invasive procedures such as those with muscle biopsies...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165747/the-effect-of-rosmarinus-officinalis-and-chemotherapeutic-etoposide-on-glioblastoma-u87-mg-cell-culture
#16
Meryem Damla Özdemir, Dilek Göktürk
AIM: Glioblastoma (GBM) is the most invasive and common type of brain cancer with very poor prognosis. One of the drugs administered for GBM pharmacotherapy is etoposide (VP-16), which belongs to the topoisomerase inhibitor family. It can be used in combination with other drugs or chemicals to avoid high dose toxicities or augment its effect at lower doses. In this study we aimed to investigate whether high dose toxicities of etoposide can be overcome when used in combination with a natural compound named Rosmarinus Officinalis...
October 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165736/the-spartacus-trial-controversies-and-unresolved-issues
#17
Felix Beuschlein, Paolo Mulatero, Evelyn Asbach, Silvia Monticone, Cristiana Catena, Leonardo A Sechi, Michael Stowasser
Adrenal vein sampling (AVS) is considered the gold standard for the differential diagnosis in patients with primary aldosteronism (PA). The distinction between unilateral and bilateral disease dictates the targeted therapeutic approach with surgery for aldosterone producing adenomas and medical therapy for patients with bilateral hyperplasia. Thereby, this diagnostic step is crucial in clinical care. As AVS is an invasive, not well standardized procedure that is restricted to few specialized centers, several attempts have been made to simplify diagnostic algorithms...
November 17, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29165718/a-phi-class-glutathione-s-transferase-gene-for-verticillium-wilt-resistance-in-gossypium-arboreum-identified-in-a-genome-wide-association-study
#18
Qian Gong, Zhaoen Yang, Eryong Chen, Gaofei Sun, Shoupu He, Hamama Islam Butt, Chaojun Zhang, Xueyan Zhang, Zuoren Yang, Xiongming Du, Fuguang Li
Verticillium wilt disease is one of the most destructive biotic stresses faced by cotton plants. Here, we performed a genome-wide association study (GWAS) in 215 Chinese Gossypium arboreum accessions inoculated as seedlings with Verticillium dahliae to identify candidate loci involved in wilt resistance. We identified 309 loci that had a significant association with Verticillium wilt resistance and Log (P) values greater than 5.0; the highest signal appeared on Ca3 in a 74 Kb haplotype block. Five genes were also located within this haplotype block...
November 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29165667/braf-v600e-mutation-assisted-risk-stratification-of-solitary-intrathyroidal-papillary-thyroid-cancer-for-precision-treatment
#19
Yueye Huang, Shen Qu, Guangwu Zhu, Fei Wang, Rengyun Liu, Xiaopei Shen, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J O'Neill, Mingzhao Xing, Mark S Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová
Background: Precise risk stratification-based treatment of solitary intrathyroidal papillary thyroid cancer (SI-PTC) that is larger than 1.0 cm and 4.0 cm or less is undefined. Methods: A genetic-clinical risk study was performed on BRAF V600E in 955 patients (768 women and 187 men) with SI-PTC, with median age of 46 years and median clinical follow-up time of 64 months at 11 medical centers in six countries. The chi-square test or, for analyses with small numbers, Fisher's exact test was performed to compare recurrence rates...
November 18, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29165661/variability-and-lack-of-prognostic-value-associated-with-atypical-pituitary-adenoma-diagnosis-a-systematic-review-and-critical-assessment-of-the-diagnostic-criteria
#20
Kelsi Chesney, Zoe Memel, Dhiraj J Pangal, Daniel Donoho, Kyle Hurth, Anna Mathew, John D Carmichael, Gabriel Zada
BACKGROUND: Atypical pituitary adenomas (APAs) are a subset of pituitary adenomas (PAs) characterized by the 2004 World Health Organization (WHO) guidelines to have higher risk histopathological features than typical PAs. In July 2017, the WHO published an update to their classification of pituitary tumors and abandoned the APA terminology. OBJECTIVE: To assess the prevalence and outcomes of patients diagnosed with APA through a literature review. Focus was placed on variation in the application of the previous WHO criteria and on rates of recurrence...
November 18, 2017: Neurosurgery
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