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https://www.readbyqxmd.com/read/29903643/the-use-of-neuromuscular-electrical-stimulation-nmes-for-managing-the-complications-of-ageing-related-to-reduced-exercise-participation
#1
REVIEW
Dominic O'Connor, Louise Brennan, Brian Caulfield
Exercise participation and activity levels are low in many older adults, and when paired with the multi-systemic effects of ageing, such as sarcopenia and decreased cardiovascular function, can result in a loss of functional independence. Voluntary exercise may not always be feasible for these individuals, highlighting a need for alternative therapies. There is a growing body of literature that recognises the positive effects of neuromuscular electrical stimulation (NMES) on muscle strength, muscle mass and cardiorespiratory function in older adults...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29845600/neuromuscular-electrostimulation-for-adults-with-chronic-obstructive-pulmonary-disease
#2
REVIEW
Kylie Hill, Vinicius Cavalheri, Sunita Mathur, Marc Roig, Tania Janaudis-Ferreira, Priscila Robles, Thomas E Dolmage, Roger Goldstein
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD), the use of neuromuscular electrostimulation (NMES) either alone, or together with conventional exercise training, might improve the condition of the peripheral muscles, increase exercise capacity and functional performance, reduce symptoms and improve health-related quality of life (HRQoL). OBJECTIVES: To determine the effects of NMES, applied in isolation or concurrently with conventional exercise training to one or more peripheral muscles, on peripheral muscle force and endurance, muscle size, exercise capacity, functional performance, symptoms, HRQoL and adverse events in people with COPD...
May 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29802953/impact-of-prolonged-neuromuscular-electrical-stimulation-on-metabolic-profile-and-cognition-related-blood-parameters-in-type-2-diabetes-a-randomized-controlled-cross-over-trial
#3
Toshiaki Miyamoto, Toshio Iwakura, Naoki Matsuoka, Masako Iwamoto, Mariko Takenaka, Yasunori Akamatsu, Toshio Moritani
AIMS: This study aimed to examine the effect of prolonged neuromuscular electrical stimulation (NMES) on the metabolic profile and cognition-related blood parameters in patients with type 2 diabetes mellitus (T2DM). METHODS: Fourteen patients with T2DM (63.2 ± 3.0 years, 76.1 ± 3.5 kg) participated in a randomized controlled cross-over study, in which 8-week-long NMES interventions were performed on both legs. The NMES training protocol consisted of 40-min sessions, 5 days per week, for 8 weeks...
May 24, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29797723/-effect-of-neuromuscular-electrical-stimulation-frequency-on-muscles-of-the-tongue
#4
Heidi Kletzien, John A Russell, Glen Leverson, Nadine P Connor
INTRODUCTION: Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model. METHODS: Eighty-six young, middle-aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100 Hz (5 days/wk, 8 wks), sham, or no implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles...
May 25, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29791704/use-of-neuromuscular-electrical-stimulation-during-physical-therapy-may-reduce-the-incidence-of-arthrofibrosis-after-total-knee-arthroplasty
#5
Chukwuweike U Gwam, Tanner McGinnis, Jennifer I Etcheson, Nicole E George, Assem A Sultan, Ronald E Delanois, Anil Bhave, Steven F Harwin, Michael A Mont
INTRODUCTION: Arthrofibrosis remains a major complication following total knee arthroplasty (TKA) that negatively impacts patient outcomes and exhausts healthcare resources. The use of neuromuscular electrical stimulation (NMES) has demonstrated the ability to facilitate quadriceps muscle recovery and reduce pain. Therefore, the purpose of this study was to compare TKA patients who received physical therapy (PT) and adjuvant NMES therapy versus physical therapy alone in terms of: 1) rates of manipulation under anesthesia (MUA) to treat arthrofibrosis; and 2) post-therapy range of motion (ROM)...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29789948/the-application-of-neuromuscular-electrical-stimulation-nmes-in-cancer-rehabilitation-current-prescription-pitfalls-and-future-directions
#6
Dominic O'Connor, Brian Caulfield
The plethora of treatment complications associated with cancer can be offset by regular exercise participation; however, adherence to current guidelines is poor, in particular in those unable or not allowed to participate in voluntary exercise due to their underlying disease. Alternative therapies such as neuromuscular electrical stimulation (NMES) are promising although previous results in cancer survivors have been equivocal. This is likely in response to methodological issues such as inappropriate NMES prescription...
May 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29788511/training-effects-of-alternated-and-pulsed-currents-on-the-quadriceps-muscles-of-athletes
#7
Pedro Oliveira, Karenina Arrais Guida Modesto, Martim Bottaro, Nicolas Babault, João Luiz Quagliotti Durigan
The aim of the study was to evaluate the effects of 6 weeks training with different neuromuscular electrical stimulation (NMES) currents (medium alternated and low-frequency pulsed current) on muscle architecture and neuromuscular performance of competitive athletes. A double-blind controlled and randomized experimental study was carried out with 33 athletes (22.2±2.6 yrs, 74.7±9.8 kg, 176.8±6.0 cm), divided into 3 groups: mid-frequency current (MF, n=12), pulsed current (PC, n=11) and the control group (CG, n=10)...
May 22, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29781580/neuromuscular-electrical-stimulation-compared-to-volitional-exercise-in-improving-muscle-function-in-rheumatoid-arthritis-a-randomized-pilot-study
#8
Sara R Piva, Samannaaz S Khoja, Frederico G S Toledo, Mary Chester Wasko, G Kelley Fitzgerald, Bret H Goodpaster, Clair N Smith, Anthony Delitto
OBJECTIVES: To compare the feasibility and effectiveness of Neuromuscular Electrical Stimulation (NMES) with high-intensity volitional resistance training in improving muscle structure and function, and physical function in patients with rheumatoid arthritis (RA). We also described pre- and post-intervention values of myocyte characteristics. METHODS: Two-group single-blinded pilot randomized study in adults with RA. Participants were assigned to 36 sessions over 16 weeks of NMES (n=31) or volitional training (n=28)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29779531/orphan-drugs-and-their-impact-on-pharmaceutical-development
#9
REVIEW
Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth
High levels of productivity, with an increasing number of approvals for new molecular entities (NMEs) by the FDA during the past decade, have coincided with the emergence of innovative drugs for treatments of rare diseases that have utilized the FDA orphan drug program. Since 2000, NMEs with orphan designation encompass a significant portion of approved drugs and constitute about 80% of the approved drugs that have established novel human genome-encoded products in recent years. Biological approvals are also expanding, with 40% of the approved biological agents having orphan designation...
June 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29777714/efficiency-of-neuromuscular-electrical-stimulation-and-transcutaneous-nerve-stimulation-on-hemiplegic-shoulder-pain-a-prospective-randomized-controlled-trial
#10
Meimei Zhou, Fang Li, Weibo Lu, Junfa Wu, Song Pei
OBJECTIVE: To compare the efficacy of neuromuscular electrical stimulation (NMES) and transcutaneous nerve stimulation (TENS) on hemiplegic shoulder pain (HSP). DESIGN: This is a prospective randomized controlled trial (RCT). SETTING: A total of 184 HSP patients, aged 18-80 years, were recruited in the Rehabilitation Hospital from February 2014 to July 2016. The Ethics approval was obtained from the Institutional Review Board of the Hospital...
May 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29760579/the-effect-of-transcutaneous-neuromuscular-electrical-stimulation-on-laryngeal-vestibule-closure-timing-in-swallowing
#11
Christopher R Watts, Matthew J Dumican
Background: The purpose of this study was to investigate the effect of transcutaneous neuromuscular electrical stimulation (NMES) on the timing of laryngeal vestibule closure during the pharyngeal stage of swallowing in healthy adults. The theoretical framework proposed that NMES applied to these muscles would present a perturbation to laryngeal vestibular closure reaction time (the amount of time for the laryngeal vestibule to close once the swallowing reflex has been triggered) by providing an antagonistic force to the direction of vestibule closure...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29758996/patterns-of-malignant-non-mass-enhancement-on-3-t-breast-mri-help-predict-invasiveness-using-the-bi-rads-lexicon-fifth-edition
#12
Seung Min Lee, Kyung Jin Nam, Ki Seok Choo, Jin You Kim, Dong Wook Jeong, Hyun Yul Kim, Jee Yeon Kim
Background Non-mass enhancements (NME) with invasive components account for 10-42% of total malignant NMEs. The factors associated with invasiveness on magnetic resonance imaging (MRI) could be useful for clinical assessment and treatment. Purpose To evaluate the clinical significances of the distributions and internal enhancement patterns (IEP) of malignant NMEs on 3-T breast MRI. Material and Methods A total of 448 consecutive women with newly diagnosed breast cancer that had undergone preoperative MRI and surgery between February 2013 and March 2016 were identified...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29751111/2017-in-review-fda-approvals-of-new-molecular-entities
#13
Michael S Kinch, Rebekah H Griesenauer
An overview of drugs approved by the FDA in 2017 reflected a reversion to the mean after a low number of NME approvals in 2016. This reversal was largely driven by the largest number of biologics-based NMEs recorded to date, which offset an average number of small-molecule approvals. Oncology indications continued to dominate followed by novel treatments for infectious, immunologic and neurologic diseases. From a mechanistic standpoint, the industry has continued a trend of target diversification, reflecting advances in scientific understanding of disease processes...
May 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29742451/muscle-plasticity-of-aged-subjects-in-response-to-electrical-stimulation-training-and-inversion-and-or-limitation-of-the-sarcopenic-process
#14
REVIEW
Thierry Paillard
This review addresses the possible structural and functional adaptations of the muscle function to neuromuscular electrical stimulation (NMES) training in frail and/or aged (without advanced chronic disease) subjects. Evidence suggests that the sarcopenic process and its structural and functional effects would be limited and/or reversed through NMES training using excito-motor currents (or direct currents). From a structural viewpoint, NMES helps reduce muscle atrophy. From a functional viewpoint, NMES enables the improvement of motor output (i...
May 6, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29738790/neuromuscular-electrical-stimulation-can-improve-mobility-in-older-adults-but-the-time-course-varies-across-tasks-double-blind-randomized-trial
#15
Diba Mani, Awad M Almuklass, Ioannis G Amiridis, Roger M Enoka
Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty healthy older adults (73.5 ± 4.8 yrs) participated in a 6-week intervention comprising 3 weekly sessions of either narrow- or wide-pulse NMES. Motor function was assessed at Weeks 0, 4, 7, and 10...
May 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29714601/influence-of-drug-lag-on-new-drug-label-revisions
#16
Chikara Kikuchi, Miyako Murakami, Hitoshi Shimomura, Shuji Shimada, Takao Aoyama
BACKGROUND: Drug lag (DL) in Japan has decreased in the last few years as a result of the globalization of drug development in the past decade, and new molecule entities (NMEs) with short DL are on the rise. The purpose of this study was to investigate the influence of DL on postmarketing safety of NMEs, by comparing the length of DL and the chronological trend of package insert revisions. METHODS: The number of label revisions occurring during 6 years after approval was investigated for 142 NMEs approved between 2000 and 2006...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29708782/mri-clinical-examination-and-mammography-for-preoperative-assessment-of-residual-disease-and-pathologic-complete-response-after-neoadjuvant-chemotherapy-for-breast-cancer-acrin-6657-trial
#17
John R Scheel, Eunhee Kim, Savannah C Partridge, Constance D Lehman, Mark A Rosen, Wanda K Bernreuter, Etta D Pisano, Helga S Marques, Elizabeth A Morris, Paul T Weatherall, Sandra M Polin, Gillian M Newstead, Laura J Esserman, Mitchell D Schnall, Nola M Hylton
OBJECTIVE: The objective of our study was to determine the accuracy of preoperative measurements for detecting pathologic complete response (CR) and assessing residual disease after neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer. SUBJECTS AND METHODS: The American College of Radiology Imaging Network 6657 Trial prospectively enrolled women with ≥ 3 cm invasive breast cancer receiving NACT. Preoperative measurements of residual disease included longest diameter by mammography, MRI, and clinical examination and functional volume on MRI...
June 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29705497/presynaptic-inhibition-mechanisms-may-subserve-the-spinal-excitability-modulation-induced-by-neuromuscular-electrical-stimulation
#18
Sidney Grosprêtre, Nicolas Gueugneau, Alain Martin, Romuald Lepers
This study aimed at deciphering the origins of spinal excitability modulation that follows neuromuscular electrical stimulation (NMES). Ten participants (age: 24.6 ± 4.2 years) performed 2 randomized NMES sessions on plantar flexors with frequencies of stimulations of 20 or 100 Hz (pulse width: 1 ms) at 20% of maximal voluntary contraction (MVC). Before and after each session, the posterior tibial nerve was stimulated to record H-reflex of soleus (SOL), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)...
April 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29689307/sensory-threshold-neuromuscular-electrical-stimulation-fosters-motor-imagery-performance
#19
Tiffany Corbet, Iñaki Iturrate, Michael Pereira, Serafeim Perdikis, José Del R Millán
Motor imagery (MI) has been largely studied as a way to enhance motor learning and to restore motor functions. Although it is agreed that users should emphasize kinesthetic imagery during MI, recordings of MI brain patterns are not sufficiently reliable for many subjects. It has been suggested that the usage of somatosensory feedback would be more suitable than standardly used visual feedback to enhance MI brain patterns. However, somatosensory feed-back should not interfere with the recorded MI brain pattern...
April 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29688861/examining-the-spatiotemporal-evolution-of-vaccine-refusal-nonmedical-exemptions-from-vaccination-in-california-2000-2013
#20
Paul L Delamater, Timothy F Leslie, Y Tony Yang
BACKGROUND: Vaccine hesitancy continues to be an issue throughout the United States, as numerous vaccine hesitant parents are choosing to exempt their children from school-entry vaccination requirements for nonmedical reasons, despite the safety and effectiveness of vaccines. We conduct an analysis of how vaccine refusal, measured by the use of nonmedical exemptions (based on personal or religious beliefs) from vaccination (NMEs), evolved across space and over time in California. METHODS: Using school-entry data from the California Department of Public Health, we examined NMEs for students entering kindergarten in California from 2000 to 2013...
April 24, 2018: BMC Public Health
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