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https://www.readbyqxmd.com/read/29457998/home-based-neuromuscular-electrical-stimulation-as-an-add-on-to-pulmonary-rehabilitation-does-not-provide-further-benefits-in-patients-with-chronic-obstructive-pulmonary-disease-a-multicenter-randomized-trial
#1
Tristan Bonnevie, Francis-Edouard Gravier, David Debeaumont, Catherine Viacroze, Jean-François Muir, Antoine Cuvelier, Marie Netchitaïlo, Anne Laure Roy, Jean Quieffin, Marie-Hélène Marques, Clément Médrinal, Johan Dupuis, Catherine Tardif
OBJECTIVE: To assess the additional effect of a home-based neuro muscular electrical stimulation (NMES) program as an add-on to pulmonary rehabilitation (PR), on functional capacity in subjects with chronic obstructive pulmonary disease (COPD). DESIGN: Single-blind, multicenter randomized trial. SETTING: Three PR centers. PARTICIPANTS: Subjects with severe to very severe COPD referred for PR (n=73; median FEV1, 1 (0...
February 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29451272/the-ndpk-nme-superfamily-state-of-the-art
#2
EDITORIAL
Mathieu Boissan, Uwe Schlattner, Marie-Lise Lacombe
Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded proteins are catalytically active NDPKs and that NM23 generally refers to clinical studies on metastasis, we use here NME/NDPK to denote the proteins. Since their discovery in the 1950's, NMEs/NDPKs have been shown to be involved in multiple physiological and pathological cellular processes, but the molecular mechanisms have not been fully determined. Recent progress in elucidating these underlying mechanisms has been presented by experts in the field at the 10th International Congress on the NDPK/NME/AWD protein family in October 2016 in Dubrovnik, Croatia, and is summarized in review articles or original research in this and an upcoming issue of Laboratory Investigation...
February 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29443103/paradigms-of-lower-extremity-electrical-stimulation-training-after-spinal-cord-injury
#3
Ashraf S Gorgey, Refka E Khalil, Robert M Lester, Gary A Dudley, David R Gater
Skeletal muscle atrophy, increased adiposity and reduced physical activity are key changes observed after spinal cord injury (SCI) and are associated with numerous cardiometabolic health consequences. These changes are likely to increase the risk of developing chronic secondary conditions and impact the quality of life in persons with SCI. Surface neuromuscular electrical stimulation evoked resistance training (NMES-RT) was developed as a strategy to attenuate the process of skeletal muscle atrophy, decrease ectopic adiposity, improve insulin sensitivity and enhance mitochondrial capacity...
February 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29434456/does-neuromuscular-electrical-stimulation-therapy-increase-voluntary-muscle-strength-after-spinal-cord-injury-a-systematic-review
#4
Gabriel Ribeiro de Freitas, Camila Szpoganicz, Jocemar Ilha
Background: Physical therapists frequently use neuromuscular electrical stimulation (NMES) therapy in an effort to increase the voluntary strength of partially paralyzed muscles in people with spinal cord injury (SCI), but it is not clear whether this treatment is effective. Objective: To determine the effectiveness of NMES for increasing voluntary strength in the partially paralyzed muscles of people with SCI. Methods: A systematic review of scientific literature was conducted in MEDLINE, CINAHL, PEDro, ScienceDirect, and Embase...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29434248/modulation-of-small-gtpase-activity-by-nme-proteins
#5
REVIEW
Vedrana Filić, Maja Marinović, Marko Šoštar, Igor Weber
NME proteins are reported to influence signal transduction activity of small GTPases from the Ras superfamily by diverse mechanisms in addition to their generic NDP kinase activity, which replenishes the cytoplasmic pool of GTP. Comprehensive evidence shows that NME proteins modulate the activity of Ras GTPases, in particular members of the Rho family, via binding to their major activators GEFs. Direct interaction between several NMEs and Ras GTPases were also indicated in vitro and in vivo. These modes of regulation are mainly independent of the NME's kinase activity...
February 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29433467/effect-of-tendon-vibration-during-wide-pulse-neuromuscular-electrical-stimulation-nmes-on-muscle-force-production-in-people-with-spinal-cord-injury-sci
#6
Vanesa Bochkezanian, Robert U Newton, Gabriel S Trajano, Amilton Vieira, Timothy S Pulverenti, Anthony J Blazevich
BACKGROUND: Neuromuscular electrical stimulation (NMES) is commonly used in skeletal muscles in people with spinal cord injury (SCI) with the aim of increasing muscle recruitment and thus muscle force production. NMES has been conventionally used in clinical practice as functional electrical stimulation (FES), using low levels of evoked force that cannot optimally stimulate muscular strength and mass improvements, and thus trigger musculoskeletal changes in paralysed muscles. The use of high intensity intermittent NMES training using wide-pulse width and moderate-intensity as a strength training tool could be a promising method to increase muscle force production in people with SCI...
February 13, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29419665/the-effects-of-physical-therapy-with-neuromuscular-electrical-stimulation-in-patients-with-septic-shock-study-protocol-for-a-randomized-cross-over-design
#7
RANDOMIZED CONTROLLED TRIAL
Alessandra Fabiane Lago, Anamaria Siriani de Oliveira, Hugo Celso Dutra de Souza, João Santana da Silva, Anibal Basile-Filho, Ada Clarice Gastaldi
INTRODUCTION: Septic shock is a potentially fatal organ dysfunction caused by an imbalance of the host response to infection. The changes in microcirculation during sepsis can be explained by the alterations in the endothelial barrier function. Endothelial progenitor cells (EPCs) are a potential recovery index of endothelial function and it an increase in response to neuromuscular electrical stimulation (NMES) was demonstrated. Therefore, the objective of this study is to investigate the effects of NMES in patients with septic shock...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29415478/empirically-derived-dietary-patterns-in-uk-adults-are-associated-with-sociodemographic-characteristics-lifestyle-and-diet-quality
#8
Katharine Roberts, Janet Cade, Jeremy Dawson, Michelle Holdsworth
The aim of this study was to examine empirical dietary patterns in UK adults and their association with sociodemographic characteristics, lifestyle factors, self-reported nutrient intake, nutrient biomarkers, and the Nutrient-based Diet Quality Score (NDQS) using National Diet and Nutrition Survey data 2008-2012 ( n = 2083; mean age 49 years; 43.3% male). Four patterns explained 13.6% of the total variance: 'Snacks, fast food, fizzy drinks' (SFFFD), 'Fruit, vegetables, oily fish' (FVOF), 'Meat, potatoes, beer' (MPB), and 'Sugary foods, dairy' (SFD)...
February 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29380329/in-vivo-electrical-stimulation-for-the-assessment-of-skeletal-muscle-contractile-function-in-murine-models
#9
Kaio F Vitzel, Marco A Fortes, Gabriel Nasri Marzuca-Nassr, Maria V M Scervino, Carlos H Pinheiro, Leonardo R Silveira, Rui Curi
Skeletal muscle electrical stimulation is commonly used for clinical purposes, assisting recovery, preservation, or even improvement of muscle mass and function in healthy and pathological conditions. Additionally, it is a useful research tool for evaluation of skeletal muscle contractile function. It may be applied in vitro, using cell culture or isolated fibers/muscles, and in vivo, using human subjects or animal models (neuromuscular electrical stimulation - NMES). This chapter focuses on the electrical stimulation of the sciatic nerve as a research method for evaluation of the contractile properties of murine hind limb muscles...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29366377/pulse-width-does-not-influence-the-gains-achieved-with-neuromuscular-electrical-stimulation-in-people-with-multiple-sclerosis-double-blind-randomized-trial
#10
Awad M Almuklass, Leah Davis, Landon D Hamilton, Jeffrey R Hebert, Enrique Alvarez, Roger M Enoka
BACKGROUND: Multiple sclerosis (MS) eventually compromises the walking ability of most individuals burdened with the disease. Treatment with neuromuscular electrical stimulation (NMES) can restore some functional abilities in persons with MS, but its effectiveness may depend on stimulus-pulse duration. OBJECTIVE: To compare the effects of a 6-week intervention with narrow- or wide-pulse NMES on walking performance, neuromuscular function, and disability status of persons with relapsing-remitting MS...
January 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29357280/effectiveness-of-neuromuscular-electrical-stimulation-on-lower-limb-hemiplegic-patients-following-chronic-stroke-a-systematic-review
#11
REVIEW
Zhongqiu Hong, Minghong Sui, Zhiqiang Zhuang, Huihua Liu, Xiuyuan Zheng, Chuanping Cai, Dongmei Jin
OBJECTIVE: To investigate the effectiveness of neuromuscular electrical stimulation (NMES) with or without other interventions in improving lower limb activity after chronic stroke. DATA SOURCE: Electronic databases including PubMed, EMBase, Cochrane Library, PEDro (Physiotherapy Evidence Database) and PsycINFO were searched from the inception to January, 2017. STUDY SELECTION: We selected the randomized controlled trials (RCTs) involving chronic stroke survivors with lower limb dysfunction and comparing NMES or combined with other interventions with control of no electrical-stimulated treatment...
January 18, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29335666/a-modified-dynamic-surface-controller-for-delayed-neuromuscular-electrical-stimulation
#12
Naji Alibeji, Nicholas Kirsch, Brad E Dicianno, Nitin Sharma
A widely accepted model of muscle force generation during neuromuscular electrical stimulation (NMES) is a second-order nonlinear musculoskeletal dynamics cascaded to a delayed first-order muscle activation dynamics. However, most nonlinear NMES control methods have either neglected the muscle activation dynamics or used an ad hoc strategies to tackle the muscle activation dynamics, which may not guarantee control stability. We hypothesized that a nonlinear control design that includes muscle activation dynamics can improve the control performance...
August 2017: IEEE/ASME Transactions on Mechatronics
https://www.readbyqxmd.com/read/29316600/impact-of-neuromuscular-electrical-stimulation-nmes-on-90-day-episode-costs-and-post-acute-care-utilization-in-total-knee-replacement-patients-with-disuse-atrophy
#13
Sarmistha Pal, Morad Chughtai, Assem A Sultan, Anton Khlopas, Nipun Sodhi, Nicole E George, Jennifer I Etcheson, Chukwuweike U Gwam, Jared M Newman, Linsen T Samuel, Anil Bhave, Joan E DaVanzo, Michael A Mont
INTRODUCTION: This study evaluated differences in: 1) total episode payments, 2) probability of hospital readmission, 3) probability of inpatient rehab facility (IRF) and utilization, and 4) probability of skilled nursing care facility (SNF) utilization in patients who had disuse atrophy and underwent a total knee arthroplasty (TKA) and either did, or did not, receive preoperative home-based neuromuscular electrical stimulation (NMES) therapy. MATERIALS AND METHODS: We used the Medicare limited dataset for a 5% sample of beneficiaries from 2014 and 2015 to construct episodes-of-care for TKA (DRG-470) patients with disuse atrophy who underwent a TKA during the 30 days prior to hospital admission and 90 days post-discharge...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29297675/discrete-fourier-transform-based-multivariate-image-analysis-application-to-modeling-aromatase-inhibitory-activity
#14
Stephen J Barigye, Matheus P Freitas, Priscila Ausina, Patricia Zancan, Mauro Sola-Penna, Juan Alberto Castillo-Garit
We have recently generalized the formerly alignment-dependent MIA-QSAR (acronym for Multivariate Image Analysis applied to Quantitative Structure Activity Relationships) method through the application of the Discrete Fourier Transform (DFT), allowing for its application to non-congruent and structurally diverse chemical compound datasets. Here, we report the first practical application of this method in the screening of molecular entities of therapeutic interest, with the human aromatase inhibitory activity as the case study...
January 3, 2018: ACS Combinatorial Science
https://www.readbyqxmd.com/read/29288590/combined-electrical-stimulation-and-exercise-for-swallow-rehabilitation-post-stroke-a-pilot-randomized-control-trial
#15
Lise Sproson, Sue Pownall, Pam Enderby, Jenny Freeman
BACKGROUND: Dysphagia is common after stroke, affecting up to 50% of patients initially. It can lead to post-stroke pneumonia, which causes 30% of stroke-related deaths, a longer hospital stay and poorer health outcomes. Dysphagia care post-stroke generally focuses on the management of symptoms, via modified oral intake textures and adapted posture, rather than direct physical rehabilitation of the swallowing function. Transcutaneous neuromuscular electrical stimulation (NMES) is a promising rehabilitation technology that can be used to stimulate swallowing; however, findings regarding efficacy have been conflicting...
December 30, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29278871/the-effect-of-surface-neuromuscular-electrical-stimulation-on-patients-with-post-stroke-dysphagia
#16
Pingping Meng, Shuchao Zhang, Qiang Wang, Peipei Wang, Chao Han, Jinghui Gao, Shouwei Yue
OBJECTIVE: To assess whether the clinical efficacy of a therapeutic protocol using surface neuromuscular electrical stimulation (sNMES) on patients with post-stroke dysphagia (PSD) is superior to that without sNMES, and whether swallowing functional outcome is different with regards to different electrode placement on patients' skin of neck. METHODS: Thirty patients with PSD were randomly allocated into treatment group A (TGA), treatment group B (TGB) and control group according to a random number table...
December 15, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29240948/early-cyclical-neuromuscular-electrical-stimulation-improves-strength-and-trophism-by-akt-pathway-signaling-in-partially-paralyzed-biceps-muscle-after-spinal-cord-injury-in-rats
#17
Gabriel R de Freitas, Caroline C do Espírito Santo, Nicolas A M M de Machado-Pereira, Franciane Bobinski, Adair R S Dos Santos, Jocemar Ilha
Background: Electrical stimulation is often used to treat weakness in people with spinal cord injury (SCI), however its efficacy to increase strength and trophism are weak and the mechanisms underlying the therapeutic benefits are unknown. Objective: The purpose of the study was to analyze the effects of neuromuscular electrical stimulation (NMES) on muscle function, trophism and the Akt pathway signaling involved in muscular plasticity after incomplete-SCI in rats...
December 12, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29240148/direct-write-micro-nano-optical-fibers-by-near-field-melt-electrospinning
#18
Qinnan Chen, Xuecui Mei, Zhe Shen, Dezhi Wu, Yang Zhao, Lingyun Wang, Xiaojun Chen, Gonghan He, Zhe Yu, Ke Fang, Daoheng Sun
A simple fabrication method of micro/nano-optical fibers (MNOFs) based on near-field melt electrospinning (NMES) is proposed in this Letter. Single fibers with diameters ranging from 500 nm to 6 μm were directly written by near-field electrospinning of molten poly(methyl methacrylate) (PMMA). The morphology and transmission characteristics of single PMMA MNOFs were experimentally measured. The results showed that PMMA MNOFs have the advantages of smooth surfaces, uniform diameters, and low loss. As an example of one-step fabrication for MNOF devices, a planar helical MNOF structure was directly written and optically characterized...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29233625/the-clinical-use-of-neuromuscular-electrical-stimulation-for-neuromuscular-rehabilitation-what-are-we-overlooking
#19
Nicola A Maffiuletti, Julien Gondin, Nicolas Place, Jennifer Stevens-Lapsley, Isabelle Vivodtzev, Marco A Minetto
The clinical success of neuromuscular electrical stimulation (NMES) for neuromuscular rehabilitation is greatly compromised by the poor consideration of different physiological and methodological issues that are not always obvious for the clinicians. Therefore, the aim of this narrative review is to re-examine some of these fundamental aspects of NMES using a tripartite model perspective. First, we contend that NMES does not actually bypass the central nervous system but results in a multitude of neurally-mediated responses that contribute substantially to force generation and may engender neural adaptations...
December 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29231243/neuromuscular-electrical-stimulation-nmes-for-patellofemoral-pain-syndrome
#20
REVIEW
Ana Luiza C Martimbianco, Maria Regina Torloni, Brenda Ng Andriolo, Gustavo Jm Porfírio, Rachel Riera
BACKGROUND: Patellofemoral pain syndrome, now generally referred to as patellofemoral pain (PFP), is one of the most common orthopaedic disorders, characterised by pain in the anterior or retropatellar knee region. Neuromuscular electrical stimulation (NMES) has been proposed generally as a complementary treatment, associated with other interventions such as exercise, or as a single treatment to increase muscle force, reduce knee pain, and improve function. OBJECTIVES: To assess the effects (benefits and harms) of neuromuscular electrical stimulation for people with patellofemoral pain...
December 12, 2017: Cochrane Database of Systematic Reviews
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