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https://www.readbyqxmd.com/read/28819679/neuromuscular-electrical-stimulation-is-effective-in-strengthening-the-quadriceps-muscle-after-anterior-cruciate-ligament-surgery
#1
REVIEW
Annette V Hauger, M P Reiman, J M Bjordal, C Sheets, L Ledbetter, A P Goode
PURPOSE: Reduced ability to contract the quadriceps muscles is often found immediately following anterior cruciate ligament (ACL) surgery. This can lead to muscle atrophy and decreased function. Application of neuromuscular electrical stimulation (NMES) may be a useful adjunct intervention to ameliorate these deficits following ACL surgery. The purpose of this review was to determine whether NMES in addition to standard physical therapy is superior to standard physical therapy alone in improving quadriceps strength or physical function following ACL surgery...
August 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28797897/ultrasonographic-quantification-of-architectural-response-in-tibialis-anterior-to-neuromuscular-electrical-stimulation
#2
Emilie Simoneau-Buessinger, Sébastien Leteneur, Alix Bisman, François Gabrielli, Jennifer Jakobi
While muscle contraction in voluntary efforts has been widely investigated, little is known about contraction during neuromuscular electrical stimulation (NMES). The aim of this study was to quantify in vivo muscle architecture of agonist and antagonist muscles at the ankle joint during NMES. Muscle fascicle lengths and pennation angles of the tibialis anterior (TA) and lateral gastrocnemius muscles were assessed via ultrasonography in 8 healthy young males. Measures were obtained during maximal NMES and torque-matched voluntary dorsiflexion contractions...
July 26, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28792587/electromyographic-bridge-for-promoting-the-recovery-of-hand-movements-in-subacute-stroke-patients-a-randomized-controlled-trial
#3
Yu-Xuan Zhou, Yang Xia, Jia Huang, Hai-Peng Wang, Xue-Liang Bao, Zheng-Yang Bi, Xiao-Bing Chen, Yu-Jie Gao, Xiao-Ying Lü, Zhi-Gong Wang
OBJECTIVE: The electromyographic bridge (EMGB) detects surface electromyographic signals from a non-paretic limb. It then generates electric pulse trains according to the electromyographic time domain features, which can be used to stimulate a paralysed or paretic limb in real time. This strategy can be used for the contralateral control of neuromuscular electrical stimulation (NMES) to improve motor function after stroke. The aim of this study was to compare the treat-ment effects of EMGB vs cyclic NMES on wrist and finger impairments in subacute stroke patients...
August 9, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28777558/high-spin-iron-imido-complexes-competent-for-c-h-bond-amination
#4
Matthew J T Wilding, Diana A Iovan, Theodore A Betley
Reduction of previously reported (ArL)FeCl with potassium graphite furnished a low-spin (S = ½) iron complex (ArL)Fe which features an intramolecular η6-arene interaction and can be utilized as an FeI synthon (ArL = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin). Treatment of (ArL)Fe with adamantyl azide or mesityl azide led to the formation of the high-spin (S = 5/2), three-coordinate imidos (ArL)Fe(NAd) and (ArL)Fe(NMes), respectively, as determined by EPR, zero-field 57Fe Mössbauer, magnetometry, and single crystal X-ray diffraction...
August 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28758085/neuromuscular-electrical-stimulation-and-strength-recovery-of-postnatal-diastasis-recti-abdominis-muscles
#5
Dalia M Kamel, Amel M Yousif
OBJECTIVE: To assess the effect of neuromuscular electrical stimulation (NMES) on the recovery of abdominal muscle strength in postnatal women with diastasis of recti abdominis muscles (DRAM). METHODS: Sixty women, 2 months postnatal, participated in this study. They were divided randomly into two equal groups. Group A received NMES in addition to abdominal exercises; group B received only abdominal exercises. The intervention in both groups was for three times per week for 8 weeks...
June 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28728611/effect-of-electrode-position-of-low-intensity-neuromuscular-electrical-stimulation-on-the-evoked-force-in-the-quadriceps-femoris-muscle
#6
Kohei Watanabe, Shuhei Kawade, Toshio Moritani
OBJECTIVE: The present study aimed to test the effect of the electrode position and inter-electrode distance on the evoked force by neuromuscular electrical stimulation (NMES) with a low current intensity and a single pair of electrodes. Knee extensor forces during NMES to quadriceps femoris muscles were compared among four different electrode configurations in seven healthy men. Electrodes were located at 10 cm proximal and 15 cm distal (P10-D15), 10 cm proximal and 10 cm distal (P10-D10), 5 cm proximal and 15 cm distal, and 5 cm proximal and 10 cm distal (P5-D10) to the center of the longitudinal axis of the quadriceps femoris muscles...
July 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28722822/-test-retest-reliability-of-wide-pulse-high-frequency-nmes-evoked-force
#7
Daria Neyroud, Sidney Grosprêtre, Julien Gondin, Bengt Kayser, Nicolas Place
INTRODUCTION: We aimed to compare forces evoked by wide-pulse high-frequency (WPHF) neuromuscular electrical stimulation (NMES) delivered to a nerve trunk vs. muscle belly and to assess their test-retest intra- and inter-individual reliability. METHODS: Forces evoked during two sessions with WPHF NMES delivered over the tibial nerve trunk and two over the triceps surae muscle belly were compared. Ten individuals participated in four sessions involving ten 20-s WPHF NMES contractions interspaced by 40 s recovery...
July 19, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28696371/biocompatibility-of-four-common-orthopedic-biomaterials-following-a-high-salt-diet-an-in-vivo-study
#8
Mathieu Lecocq, Cécile Bernard, Marie Solenne Felix, Jean-Marc Linares, Julien Chaves-Jacob, Patrick Decherchi, Erick Dousset
Nowadays, salt consumption appears to be drastically above the recommended level in industrialized countries. The health consequences of this overconsumption are heavy since high-salt intake induces cardiovascular disease, kidney dysfunction, and stroke. Moreover, harmful interaction may also occur with orthopaedic devices because overconsumption of salt reinforces the corrosive aspect of biological tissues and favors bone resorption process. In the present study, we aimed to assess the in vivo effect of three weeks of a high-salt diet, associated (or not) with two weeks of the neuro-myoelectrostimulation (NMES) rehabilitation program on the biocompatibility of four biomaterials used in the manufacture of arthroplasty implants...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28689370/intra-target-microdosing-a-novel-drug-development-approach-proof-of-concept-safety-and-feasibility-study-in-humans
#9
T Burt, D MacLeod, K Lee, A Santoro, D K DeMasi, T Hawk, M Feinglos, M Rowland, R J Noveck
Intra-target microdosing (ITM) is a novel drug development approach aimed at increasing the efficiency of first-in-human (FIH) testing of new molecular entities (NMEs). ITM combines intra-target drug delivery and "microdosing," the subpharmacological systemic exposure. We hypothesized that when the target tissue is small (about 1/100th of total body mass), ITM can lead to target therapeutic-level exposure with minimal (microdose) systemic exposure. Each of five healthy male volunteers received insulin microdose into the radial artery or full therapeutic dose intravenously in separate visits...
July 8, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28687460/2016-in-review-fda-approvals-of-new-molecular-entities
#10
Rebekah H Griesenauer, Michael S Kinch
An overview of drugs approved by FDA in 2016 reveals dramatic disruptions in long-term trends. The number of new molecular entities (NMEs) dropped, reflecting the lowest rate of small-molecule approvals observed in almost five decades. In addition, the pace of industry consolidation slowed substantially. The impact of mergers and acquisitions decreased the total number of organizations with past approval experience and continued research and development (R&D) activities to 102, divided evenly between more established pharmaceutical and newer biotechnology companies...
July 4, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28674922/effects-of-training-programs-based-on-ipsilateral-voluntary-and-stimulated-contractions-on-muscle-strength-and-monopedal-postural-control-of-the-contralateral-limb
#11
Mohamed Abdelhafid Kadri, Frederic Noé, Merbouha Boulahbel Nouar, Thierry Paillard
PURPOSE: To compare the effects of unilateral strength training by stimulated and voluntary contractions on muscle strength and monopedal postural control of the contralateral limb. METHODS: 36 non-active healthy male subjects were recruited and split randomly into three groups. Two groups of 12 subjects took part in a strength-training program (3 sessions a week over 8 weeks) comprising 43 contractions of the quadriceps femoris of the ipsilateral limb (at 20% of the MVC)...
July 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28652015/landscape-of-innovation-for-cardiovascular-pharmaceuticals-from-basic-science-to-new-molecular-entities
#12
Jennifer M Beierlein, Laura M McNamee, Michael J Walsh, Kenneth I Kaitin, Joseph A DiMasi, Fred D Ledley
PURPOSE: This study examines the complete timelines of translational science for new cardiovascular therapeutics from the initiation of basic research leading to identification of new drug targets through clinical development and US Food and Drug Administration (FDA) approval of new molecular entities (NMEs) based on this research. METHODS: This work extends previous studies by examining the association between the growth of research on drug targets and approval of NMEs associated with these targets...
July 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28636643/neuromuscular-electrical-stimulation-prevents-skeletal-muscle-dysfunction-in-adjuvant-induced-arthritis-rat
#13
Koichi Himori, Daisuke Tatebayashi, Keita Kanzaki, Masanobu Wada, Håkan Westerblad, Johanna T Lanner, Takashi Yamada
Skeletal muscle weakness is a prominent feature in patients with rheumatoid arthritis (RA). In this study, we investigated whether neuromuscular electrical stimulation (NMES) training protects against skeletal muscle dysfunction in rats with adjuvant-induced arthritis (AIA). AIA was produced by intraarticular injection of complete Freund's adjuvant into the knees of Wistar rats. For NMES training, dorsiflexor muscles were stimulated via a surface electrode (0.5 ms pulse, 50 Hz, 2 s on/4 s off). NMES training was performed every other day for three weeks and consisted of three sets produced at three min intervals...
2017: PloS One
https://www.readbyqxmd.com/read/28621488/effects-of-intradialytic-neuromuscular-electrical-stimulation-on-strength-and-muscle-architecture-in-patients-with-chronic-kidney-failure-randomized-clinical-trial
#14
Jociane Schardong, Thiago Dipp, Camila Bassani Bozzeto, Marília Godoy da Silva, Gabriela Leivas Baldissera, Raíssa de Castro Ribeiro, Bruna Pan Valdemarca, Alexandre Severo do Pinho, Graciele Sbruzzi, Rodrigo Della Méa Plentz
This study aimed to evaluate the effects of neuromuscular electrical stimulation (NMES) on muscle strength and architecture, functional capacity, and endothelial function in patients with chronic kidney failure (CKF) on hemodialysis (HD). Twenty-one patients with CKF on HD were randomized into a control group (CG; n = 10) and neuromuscular electrical stimulation group (NMESG; n = 11) who received NMES in the quadriceps muscle for 8 weeks, 3 times/week (20-34 min) during HD sessions. The muscle strength of the lower limbs was evaluated by dynamometry and sit-and-stand test (SST); muscle architecture through ultrasonography; functional capacity by the distance covered in a 6-min walk test and the endothelial function by flow-mediated dilatation technique of the brachial artery...
June 16, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28610968/comparison-of-the-effect-of-sensory-level-and-conventional-motor-level-neuromuscular-electrical-stimulation-on-quadriceps-strength-after-total-knee-arthroplasty-a-prospective-randomized-single-blind-trial
#15
Yosuke Yoshida, Koki Ikuno, Koji Shomoto
OBJECTIVE: To compare sensory-level neuromuscular electrical stimulation (sNMES) and conventional motor- level neuromuscular electrical stimulation (mNMSE ) in patients after total knee arthroplasty (TKA). DESIGN: A prospective randomized single-blind trial. SETTING: A hospital total arthroplasty center: inpatients. PARTICIPANTS: Patients with osteoarthritis (N=66, 85% women, mean age 73.5±6.3y) were randomized to receive either sNMES applied to the quadriceps (the sNMES group), mNMES (the mNMES group), or no stimulation (the Control group) in addition to a standard rehabilitation program...
June 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28577338/specific-brain-activation-patterns-associated-with-two-neuromuscular-electrical-stimulation-protocols
#16
Jennifer Wegrzyk, Jean-Philippe Ranjeva, Alexandre Fouré, Anne Kavounoudias, Christophe Vilmen, Jean-Pierre Mattei, Maxime Guye, Nicola A Maffiuletti, Nicolas Place, David Bendahan, Julien Gondin
The influence of neuromuscular electrical stimulation (NMES) parameters on brain activation has been scarcely investigated. We aimed at comparing two frequently used NMES protocols - designed to vary in the extent of sensory input. Whole-brain functional magnetic resonance imaging was performed in sixteen healthy subjects during wide-pulse high-frequency (WPHF, 100 Hz-1 ms) and conventional (CONV, 25 Hz-0.05 ms) NMES applied over the triceps surae. Each protocol included 20 isometric contractions performed at 10% of maximal force...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28572500/neuromuscular-electrical-stimulation-improves-skeletal-muscle-regeneration-through-satellite-cell-fusion-with-myofibers-in-healthy-elderly-subjects
#17
Ester Sara Di Filippo, Rosa Mancinelli, Mariangela Marrone, Christian Doria, Vittore Verratti, Luana Toniolo, Josè Luiz Dantas, Stefania Fulle, Tiziana Pietrangelo
The aim was to determine whether neuromuscular electrical stimulation (NMES) affects skeletal muscle regeneration through a reduction of oxidative status in satellite cells of healthy elderly subjects. Satellite cells from the Vastus lateralis skeletal muscle of 12 healthy elderly subjects before and after 8 weeks of NMES were allowed to proliferate to provide myogenic populations of adult stem cells (myogenic precursor cells; MPCs). These MPCs were then investigated in terms of their proliferation, their basal cytoplasmic free Ca(2+) concentrations, and their expression of myogenic regulatory factors (PAX3, PAX7, MYF5, MYOD, MYOG) and microRNAs (miR-1, miR-133a/b, miR-206)...
June 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28567858/optimization-of-interphase-intervals-to-enhance-the-evoked-muscular-responses-of-transcutaneous-neuromuscular-electrical-stimulation
#18
Jose Luis Vargas Luna, Matthias Krenn, Winfried Mayr, Jorge Armando Cortés Ramírez
Neuromuscular electrical stimulation (NMES) is a widely used technique for clinical diagnostic, treatment, and research. Normally, it applies charge-balanced biphasic pulses, which several publications have reported to be less efficient than monophasic pulses. A good alternative is the use of interphase intervals (IPI) on biphasic pulses that allows to achieve similar responses than those evoked by monophasic stimulation. This study analyzes the enhancing mechanism of the IPI and provides guidelines on how to optimize the IPI in order to reduce secondary effects such as the electrode corrosion...
June 1, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28556590/biocompatibility-of-four-common-orthopedic-biomaterials-following-neuroelectromyostimulation-an-in-vivo-study
#19
Lecocq Mathieu, Felix Marie-Solenne, Bernard Cécile, Linares Jean-Marc, Chaves-Jacob Julien, Decherchi Patrick, Dousset Erick
Despite the worldwide high prevalence of total joint arthroplasty (TJA), life expectancy of prosthesis remains limited by mechanical and chemical constraint which promote wear debris production, surrounding tissues damage and finally prosthesis loosening. Such results could be amplified by neuro-myoelectrostimulation (NMES; widely used to reduce neuromuscular deficits observed following TJA surgery). It was previously described in an in vivo experiment that interactions between NMES and Ti6Al4V implant are deleterious for both implant and surrounding muscles...
May 29, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28527228/efficacy-of-neuromuscular-electrical-stimulation-for-preventing-quadriceps-muscle-wasting-in-patients-with-moderate-or-severe-acute-stroke-a-pilot-study
#20
Masafumi Nozoe, Masashi Kanai, Hiroki Kubo, Yuka Takeuchi, Miki Kobayashi, Miho Yamamoto, Asami Furuichi, Makoto Yamazaki, Shinichi Shimada, Kyoshi Mase
BACKGROUND: Stroke-related muscle wasting is one of the factors leading to long-term disability and functional dependency. No study has reported an effective therapeutic intervention for such muscle wasting. OBJECTIVE: The purpose of this study was to investigate the effects of neuromuscular electrical stimulation (NMES) on quadriceps muscle mass preservation in patients with acute moderate or severe stroke by using ultrasonography (US). METHODS: Twenty patients with acute, moderate, or severe stroke (age: 68±11 years) were divided into usual care group (control group) and intervention groups (NMES group), respectively...
2017: NeuroRehabilitation
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