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https://www.readbyqxmd.com/read/27887891/high-intake-of-nonmilk-extrinsic-sugars-is-associated-with-protein-and-micronutrient-dilution-in-home-dwelling-and-institutionalized-older-people
#1
Satu K Jyväkorpi, Kaisu H Pitkälä, Taija M Puranen, Mikko P Björkman, Hannu Kautiainen, Timo E Strandberg, Helena Soini, Merja H Suominen
BACKGROUND: High dietary sugar intake may compromise protein and micronutrient intakes in people with low energy intakes. The results of micronutrient dilution studies in older people have been few and conflicting. We examined the nutritional status and nutrient intakes associated with nonmilk extrinsic sugars (NMES) intakes in older people representing a broad spectrum of both healthy and vulnerable older populations. DESIGN AND PARTICIPANTS: This cross-sectional study combined five Finnish data sets covering home-dwelling (n = 526) and institutionalized (n = 374) older people...
November 22, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27883244/a-redox-switchable-germylene-and-its-ligating-properties-in-selected-transition-metal-complexes
#2
Florian Walz, Eric Moos, Delphine Garnier, Ralf Köppe, Christopher E Anson, Frank Breher
The synthesis, structure, and full characterization of a redox-switchable germylene based on a [3]ferrocenophane ligand arrangement, [Fc(NMes)2Ge] (4), is presented. The title compound is readily available from Fc(NHMes)2 (2) and Ge{N(SiMe3)2}2, or from the dilithiated compound Fc(NLiMes)2 · 3 Et2O (3) and GeCl2. Cyclic voltammetry studies are provided for 4 confirming the above mentioned view of a redox-switchable germylene metalloligand. Although several 1:1 Rh(I) and Ir(I) complexes of 4 (5 - 7) are cleanly formed in solution, all attempts to isolate them in pure form failed due to stability problems...
November 24, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27862023/fatigue-reduction-during-aggregated-and-distributed-sequential-stimulation
#3
Austin J Bergquist, Vishvek Babbar, Saima Ali, Milos R Popovic, Masani Kei
INTRODUCTION: Transcutaneous neuromuscular electrical stimulation (NMES) can generate muscle contractions for rehabilitation and exercise. However, NMES-evoked contractions are limited by fatigue when they are delivered "conventionally" (CONV) using a single active electrode. Researchers developed "sequential" (SEQ) stimulation, involving rotation of pulses between multiple "aggregated" (AGGR-SEQ) or "distributed" (DISTR-SEQ) active electrodes, to reduce fatigue (torque-decline) by reducing motor unit discharge rates...
November 11, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27859286/effects-of-electrical-stimulation-on-vocal-functions-in-patients-with-nasopharyngeal-carcinoma
#4
Thomas Law, Kathy Y-S Lee, Rita W-M Wong, Yeptain Leung, Peter K-M Ku, Eddy W-Y Wong, Hok-Nam Li, Louisa K-Y Ng, C Andrew van Hasselt, Michael C-F Tong
OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the effects of neuromuscular electrical stimulation (NMES) on vocal functions in patients with nasopharyngeal carcinoma following radiation therapy. STUDY DESIGN: Prospective, randomized controlled trial. METHODS: One hundred forty newly treated NPC patients were recruited and randomized into NMES or traditional swallowing exercise (TE) group. Participants received intensive NMES or traditional swallowing therapy and were followed up until 12 months postrandomization...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853486/magnetic-resonance-imaging-features-of-idiopathic-granulomatous-mastitis-a-retrospective-analysis
#5
Necdet Poyraz, Ganime Dilek Emlik, Abdussamet Batur, Ebubekir Gundes, Suat Keskin
BACKGROUND: Granulomatous mastitis is a rare and benign inflammatory breast disease that may clinically and radiologically mimic breast cancer. OBJECTIVES: The aim of this study was to evaluate the features of idiopathic granulomatous mastitis (IGM) on breast magnetic resonance imaging (MRI) with mammographic and sonographic findings. PATIENTS AND METHODS: A retrospective analysis was conducted on 20 patients with IGM who had been diagnosed by needle core or excisional biopsy at a single institution between 2006 and 2012...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27845664/the-time-varying-nature-of-electromechanical-delay-and-muscle-control-effectiveness-in-response-to-stimulation-induced-fatigue
#6
Ryan J Downey, Manelle Merad, Eric J Gonzalez, Warren E Dixon
Neuromuscular Electrical Stimulation (NMES) and Functional Electrical Stimulation (FES) are commonly prescribed rehabilitative therapies. Closed-loop NMES holds the promise to yield more accurate limb control, which could enable new rehabilitative procedures. However, NMES/FES can rapidly fatigue muscle, which limits potential treatments and presents several control challenges. Specifically, the stimulation intensity-force relation changes as the muscle fatigues. Additionally, the delayed response between the application of stimulation and muscle force production, termed electromechanical delay (EMD), may increase with fatigue...
November 8, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27834612/the-effectiveness-of-neuromuscular-electrical-stimulation-in-improving-voluntary-activation-of-the-quadriceps-a-critically-appraised-topic
#7
Cody B Bremner, William R Holcomb, Christopher D Brown, Melanie E Perreault
: Clinical Scenario: Orthopedic knee conditions are regularly treated in sports medicine clinics. Rehabilitation protocols for these conditions are often designed to address the associated quadriceps strength deficits. Despite these efforts, patients with orthopedic knee conditions often fail to completely regain their quadriceps strength. Disinhibitory modalities have recently been suggested as a clinical tool that can be used to counteract the negative effects of arthrogenic muscle inhibition (AMI), which is believed to limit the effectiveness of therapeutic exercise...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27832594/high-frequency-neuromuscular-electrical-stimulation-modulates-interhemispheric-inhibition-in-healthy-humans
#8
Nicolas Gueugneau, Sidney Grosprêtre, Paul J Stapley, Romuald Lepers
High frequency neuromuscular electrical stimulation (HF NMES) induces muscular contractions through neural mechanisms that partially match physiological motor control. Indeed, a portion of the contraction arises from central mechanisms, whereby spinal motoneurons are recruited through the evoked sensory volley. However, the involvement of supraspinal centers of motor control during such a stimulation remained poorly understood. Therefore, we tested whether a single HF NMES session applied to the upper limb influences interhemispheric inhibition (IHI) from left to right motor cortex (M1)...
November 9, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27821435/what-can-be-learned-from-recent-new-drug-applications-a-systematic-review-of-drug-interaction-data-for-drugs-approved-by-the-u-s-fda-in-2015
#9
Jingjing Yu, Zhu Zhou, Katie H Owens, Tasha K Ritchie, Isabelle Ragueneau-Majlessi
As a follow-up to previous reviews, the aim of the present analysis was to systematically examine all drug metabolism, transport, PK, and DDI data available in the 33 NDAs and 12 BLAs approved by the FDA in 2015, using the University of Washington Drug Interaction Database©, and to highlight the significant findings. All of the NDAs were well-characterized with regard to drug metabolism, transport, and/or organ impairment, and were fully analyzed in this review. In vitro, a majority of the NMEs were found to be substrates or inhibitors/inducers of at least one DME or transporter...
November 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27818472/a-single-session-of-neuromuscular-electrical-stimulation-enhances-vascular-endothelial-function-and-peripheral-blood-circulation-in-patients-with-acute-myocardial-infarction
#10
Shinya Tanaka, Takashi Masuda, Kentaro Kamiya, Nobuaki Hamazaki, Ayako Akiyama, Yumi Kamada, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Junya Ako
This study aimed to investigate whether a single session of neuromuscular electrical stimulation (NMES) can enhance vascular endothelial function and peripheral blood circulation in patients with acute myocardial infarction (AMI). Thirty-four male patients with AMI were alternately assigned to 2 groups, and received NMES with muscle contraction (NMES group, n = 17) or without muscle contraction (control group, n = 17) after admission. NMES was performed for quadriceps and gastrocnemius muscles of both legs for 30 minutes...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27815950/a-randomized-double-blind-placebo-controlled-study-of-neuromuscular-electrical-stimulation-nmes-use-for-recovery-after-elective-total-hip-replacement-surgery
#11
Jerome J Castellano, Ana-Marie Rojas, Raj Karia, Tracey Hunter, James Slover, Alex Moroz
Early physical activity has been proven to accelerate functional recovery after total hip replacement (THR). Weightbearing intolerance secondary to postoperative pain inhibits participation in physical therapy and limits the achievement of functional independence. Neuromuscular electrical stimulation (NMES) has been shown to improve pain and accelerate recovery. This study focused on the effects of NMES on weightbearing pain. The primary objective of this study was to compare the efficacy of NMES versus placebo in the reduction of pain and the use of opiate medications in the treatment of patients during weightbearing exercises after THR...
November 2016: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/27813169/heavier-group-13-metal-i-heterocycles-stabilized-by-sterically-demanding-diiminophosphinates-a-structurally-characterized-monomer-dimer-pair-for-gallium
#12
Andrew L Hawley, C André Ohlin, Lea Fohlmeister, Andreas Stasch
We have synthesized and characterized the monomeric diiminophosphinate-stabilized Group 13 metal(I) complexes [(Dip) LE:], (Dip) L=Ph2 P(NDip)2 , Dip=2,6-iPr2 C6 H3 ; E=Ga (1), In (2) and Tl (3). In addition, we structurally characterized the dimeric complex [((Dip) LGa)2 ], 12 . Similar synthetic attempts using (Mes) L=Ph2 P(NMes)2 , Mes=2,4,6-Me3 C6 H2 afforded product mixtures from which the mixed oxidation state species [((Mes) L)3 Ga4 I3 ] 4 was isolated. [(Dip) LGa:] 1 is converted with dry air to the gallium(III) oxide species [((Dip) LGaO)2 ] 5...
November 3, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27793340/neuromuscular-electrical-stimulation-may-attenuate-muscle-proteolysis-after-cardiovascular-surgery-a-preliminary-study
#13
Kotaro Iwatsu, Yuki Iida, Yuji Kono, Takenori Yamazaki, Akihiko Usui, Sumio Yamada
OBJECTIVE: To explore the efficacy of postoperative neuromuscular electrical stimulation (NMES) on muscle protein degradation and muscle weakness in patients after cardiovascular surgery. METHODS: Sixty-one patients underwent NMES daily from postoperative days (PODs) 1 to 5 in addition to postoperative mobilization program (NMES group), and 41 patients underwent postoperative mobilization program only (non-NMES group). The primary outcome was the concentration of 3-methylhistidine (3-MH) in 24-hour urine corrected for urinary creatinine content (3-MH/Cre) from PODs 1 to 5...
September 23, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27789768/neuromuscular-electrical-stimulation-prior-to-pre-sleep-protein-feeding-stimulates-the-use-of-protein-derived-amino-acids-for-overnight-muscle-protein-synthesis
#14
Marlou L Dirks, Bart B L Groen, Rinske Franssen, Janneau van Kranenburg, Luc J C van Loon
BACKGROUND: Short periods of muscle disuse result in substantial skeletal muscle atrophy. Recently, we showed that both neuromuscular electrical stimulation (NMES) as well as pre-sleep dietary protein ingestion represent effective strategies to stimulate muscle protein synthesis rates. In this study we test our hypothesis that NMES can augment the use of pre-sleep protein-derived amino acids for overnight muscle protein synthesis in older males. METHODS: Twenty healthy, older (69±1 y) males were subjected to 24 h of bed rest, starting at 8:00 AM...
October 27, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27748503/neuromuscular-electrical-stimulation-for-muscle-weakness-in-adults-with-advanced-disease
#15
REVIEW
Sarah Jones, William D-C Man, Wei Gao, Irene J Higginson, Andrew Wilcock, Matthew Maddocks
BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews Issue 1, 2013 on Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease.Patients with advanced progressive disease often experience muscle weakness, which can impact adversely on their ability to be independent and their quality of life. In those patients who are unable or unwilling to undertake whole-body exercise, neuromuscular electrical stimulation (NMES) may be an alternative treatment to enhance lower limb muscle strength...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27736286/does-preoperative-physiotherapy-improve-postoperative-patient-based-outcomes-in-older-adults-who-have-undergone-total-knee-arthroplasty-a-systematic-review
#16
Ross Alexander Chesham, Sivaramkumar Shanmugam
BACKGROUND: Knee osteoarthritis (OA) is a leading cause of disability in older adults (≥60) in the UK. If nonsurgical management fails and if OA severity becomes too great, knee arthroplasty is a preferred treatment choice. Preoperative physiotherapy is often offered as part of rehabilitation to improve postoperative patient-based outcomes. OBJECTIVES: Systematically review whether preoperative physiotherapy improves postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty (TKA) and compare study interventions to best-practice guidelines...
October 13, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27732921/safety-and-feasibility-of-a-neuromuscular-electrical-stimulation-chronaxie-based-protocol-in-critical-ill-patients-a-prospective-observational-study
#17
Paulo Eugênio Silva, Nicolas Babault, João Batista Mazullo, Tamires Pereira de Oliveira, Bárbara Letícia Lemos, Vitor Oliveira Carvalho, Joao Luiz Quagliotti Durigan
PURPOSE: The aim of this study was to evaluate the safety and feasibility of a neuromuscular electrical stimulation (NMES) protocol based on neuromuscular excitability and applied in numerous muscle groups of critical ill patients. MATERIALS AND METHODS: We performed a prospective observational study using an NMES applied daily and bilaterally into 5 muscle groups in lower limbs for 3 consecutive days. The characteristics of NMES were 90 contractions per muscle, pulse width equal to chronaxie, and a pulse frequency of 100 Hz...
September 22, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27732639/transactivation-assays-to-assess-canine-and-rodent-pregnane-x-receptor-pxr-and-constitutive-androstane-receptor-car-activation
#18
Marija Pinne, Elsa Ponce, Judy L Raucy
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake of both endogenous substrates and xenobiotics. Activation of these receptors can lead to adverse drug effects as well as drug-drug interactions. Depending on which nuclear receptor is activated will determine which adverse effect could occur, making identification important...
2016: PloS One
https://www.readbyqxmd.com/read/27728864/neuromuscular-electrical-stimulation-for-muscle-wasting-in-heart-failure-patients
#19
Masakazu Saitoh, Marcelo Rodrigues Dos Santos, Markus Anker, Stefan D Anker, Stephan von Haehling, Jochen Springer
Neuromuscular electrical stimulation (NMES) seems to be safe and beneficial in improvement in functional capacity, muscle strength, and quality of life when compared with conventional aerobic exercise, while the change in muscle fiber composition and muscle size was conflicting in patients with heart failure (HF). Moreover, NMES studies seem to have beneficial effects on pro-inflammatory cytokine, oxidative enzyme activity, and protein anabolic and catabolic metabolism that are the key molecular mechanism of muscle wasting in patients with HF...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27695905/the-efficacy-of-post-operative-devices-following-knee-arthroscopic-surgery-a-systematic-review
#20
Corey T Gatewood, Andrew A Tran, Jason L Dragoo
PURPOSE: There is a wide array of device modalities available for post-operative treatment following arthroscopic knee surgery; however, it remains unclear which types and duration of modality are the most effective. This systematic review aimed to investigate the efficacy of device modalities used following arthroscopic knee surgery. METHODS: A systematic search of the literature was performed on: PubMed; Scopus; MEDLINE; EMBASE; PEDro; SportDiscus; and CINAHL databases (1995-2015) for clinical trials using device modalities following arthroscopic knee surgery: cryotherapy, continuous passive motion (CPM), neuromuscular electrical stimulation (NMES), surface electromyographic (sEMG) biofeedback and shockwave therapy (ESWT)...
October 1, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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