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Vicent Esteve, José Carneiro, Fátima Moreno, Miquel Fulquet, Salud Garriga, Mónica Pou, Verónica Duarte, Anna Saurina, Irati Tapia, Manel Ramírez de Arellano
INTRODUCTION: Haemodialysis (HD) patients are characterised by significant muscle loss. Recently, neuromuscular electrical stimulation (NMES) has emerged as a new therapeutic alternative to improve these patients' physical condition. To date, no studies on the effects of NMES on body composition in HD patients have been published. OBJECTIVE: To analyse the effect of NMES on muscle strength, functional capacity and body composition in our HD patients. MATERIAL AND METHODS: A 12-week, single-centre, prospective study...
August 26, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Andreas Schindler, Andreas Bartels
High-level regions of the ventral stream exhibit strong category selectivity to stimuli such as faces, houses, or objects. However, recent studies suggest that at least part of this selectivity stems from low-level differences inherent to images of the different categories. For example, visual outdoor and indoor scenes as well as houses differ in spatial frequency, rectilinearity and obliqueness when compared to face or object images. Correspondingly, scene responsive para-hippocampal place area (PPA) showed strong preference to low-level properties of visual scenes also in the absence of high-level scene content...
May 15, 2016: NeuroImage
Keping Yang, Yunfeng Zhang, Chenhong Xu, Xin Li, Dazhu Li
Post-infarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction (MI). Supression of post-infarction inflammation would be a logical approach of alleviating post-infarction injury and promoting cardiac repair. In this study, we investigated the significance of mTORC1 signaling in the anti-inflammatory activity of regulatory T cells (Tregs) after MI. Using the murine MI model with wild type and Rag1(-/-) mice, we found that the mechanistic target of rapamycin compex 1 (mTORC1) signaling was upregulated in Tregs infiltrating into the infarcted myocardium, rather than in circulating Tregs after MI...
March 2016: Immunology and Cell Biology
H-J Trappe
The surface electrocardiogram (ECG) is an important diagnostic tool for the diagnosis of arrhythmias and acute coronary syndrome. Arrhythmias are divided into bradycardias (heart rate < 50/min) and tachycardias (heart rate > 100/min). Among tachycardias, differentiation between small QRS complexes (QRS width < 0.12 s) and broad QRS compexes (≥ 0.12 s) during tachycardia is necessary. It is important to analyze the relationship between P wave and QRS complex, to look for an electric alternans as a leading finding for an accessory pathway...
September 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial respiration. This significantly attenuates an oxidative stress and reduces the extent of HI brain injury. Neonatal mice were subjected to HI, and at the initiation of reperfusion were exposed to isoflurane with or without mechanical ventilation. At the end of HI and isoflurane exposure cerebral mitochondrial respiration, H2O2 emission rates were measured followed by an assessment of cerebral oxidative damage and infarct volumes...
2015: PloS One
Andrei N Lupas, Hongbo Zhu, Mateusz Korycinski
Despite having caused one of the greatest medical catastrophies of the last century through its teratogenic side-effects, thalidomide continues to be an important agent in the treatment of leprosy and cancer. The protein cereblon, which forms an E3 ubiquitin ligase compex together with damaged DNA-binding protein 1 (DDB1) and cullin 4A, has been recently indentified as a primary target of thalidomide and its C-terminal part as responsible for binding thalidomide within a domain carrying several invariant cysteine and tryptophan residues...
January 2015: PLoS Computational Biology
Federico Galvagni, Claudia Lentucci, Francesco Neri, Daniela Dettori, Caterina De Clemente, Maurizio Orlandini, Francesca Anselmi, Stefania Rapelli, Michela Grillo, Sara Borghi, Salvatore Oliviero
Although much is known about the pluripotency self-renewal circuitry, the molecular events that lead embryonic stem cells (ESCs) exit from pluripotency and begin differentiation are largely unknown. We found that the zinc finger transcription factor Snai1, involved in gastrulation and epithelial-mesenchymal transition, is already expressed in the inner cell mass of the preimplantation blastocysts. In ESCs, Snai1 does not respond to TGFβ or BMP4 signaling but it is induced by retinoic acid treatment, which induces the binding, on the Snai1 promoter, of the retinoid receptors RARγ and RXRα, the dissociation of the Polycomb repressor complex 2 which results in the decrease of H3K27me3, and the increase of histone H3K4me3...
March 2015: Stem Cells
William R Branch, Julian Bayliss, Krystal A Tolley
The taxonomic status of recently discovered populations of pygmy chameleons (Rhampholeon) from the northern Mozambique montane isolates of Mt. Chiperone, Mt. Mabu, Mt. Inago and Mt. Namuli are assessed, and compared with the closest geographical congeners, including Rhampholeon platyceps Günther 1893 from Mt. Mulanje, and Rh. chapmanorum Tilbury 1992 from the Malawi Hills, both in southern Malawi. Relationships were examined using morphological features and a phylogenetic analysis incorporating two mitochondrial and one nuclear marker...
2014: Zootaxa
Rima Raffoul Khoury, Gordon J Sutton, Diako Ebrahimi, D Brynn Hibbert
We report a systematic study of the effects of types and positions of amino acid residues of tripeptides on the formation constants logβ, acid dissociation constants pKa, and the copper coordination modes of the copper(II) complexes with 27 tripeptides formed from the amino acids glutamic acid, glycine, and histidine. logβ values were calculated from pH titrations with l mmol L(-1):1 mmol L(-1) solutions of the metal and ligand and previously reported ligand pKa values. Generalized multiplicative analysis of variance (GEMANOVA) was used to model the logβ values of the saturated, most protonated, monoprotonated, logβ(CuL) - logβ(HL), and pKa of the amide group...
February 3, 2014: Inorganic Chemistry
Serkan Celik, Fatih Tangi, Emrah Kilicaslan, Yavuz S Sanisoglu, Cagatay Oktenli, Cihan Top
OBJECTIVE: As little is known about relationship between acylation stimulating protein (ASP) and oxidative stress, whether there is any link between ASP and oxidative stress in young obese males were investigated. DESIGN AND METHODS: Forty-five obese (median body mass index (BMI) = 36.99 (IQR = 3.65) kg m(-2)) male subjects (median age = 22 (IQR = 6) years) and 24 age-matched (median age = 22.5 (IQR = 4.8) years) healthy male volunteers (median body mass index (BMI) = 23...
August 2013: Obesity
Kang-Ling Liao, Xue-Feng Bai, Avner Friedman
CD200 is a cell membrane protein that interacts with CD200 receptor (CD200R) of myeloid lineage cells. During tumor initiation and progression, CD200-positive tumor cells can interact with M1 and M2 macrophages through CD200-CD200R-compex, and downregulate IL-10 and IL-12 productions secreted primarily by M2 and M1 macrophages, respectively. In the tumor microenvironment, IL-10 inhibits the activation of cytotoxic T lymphocytes (CTL), while IL-12 enhances CTL activation. In this paper, we used a system approach to determine the combined effect of CD200-CD200R interaction on tumor proliferation by developing a mathematical model...
July 7, 2013: Journal of Theoretical Biology
Sumanta Kumar Padhi, Ryoichi Fukuda, Masahiro Ehara, Koji Tanaka
Cyclometalated ruthenium complexes having C(^)N and N(^)C type coordinating ligands with NAD(+)/NADH function have been synthesized and characterized by spectroscopic methods. The variation of the coordinating position of σ-donating carbon atom leads to a drastic change in their properties. Both the complex Ru(phbn)(phen)(2)]PF(6) ([1]PF(6)) and [Ru(pad)(phen)(2)]PF(6) ([2]PF(6)) reduced to Ru(phbnHH)(phen)(2)]PF(6) ([1HH]PF(6)) and [Ru(padHH)(phen)(2)]PF(6) ([2HH]PF(6)) by chemical and electrochemical methods...
August 6, 2012: Inorganic Chemistry
Natalia Vodzinska, Boris Galkin, Yuriy Ishkov, Anna Kirichenko, Alexandra Kondratyuk, Tetiana Filipova
The influence of free base of quinolinilporphyrin and its Zn complex on infectivity of lactophages E3, E5 and E17 has been studied. The results of our investigations show that inhibition of lactophage activity by Zn complex of quinolinilporphyrin at concentration 10 microM and 20 microM was in the range 53-62% and 65-85%, respectively. The presence of this porphyrin in nutrient medium prevents the propagation of bacteriophage infection in Lactococcus lactis, but does not affect the phage adsorption process...
2011: Polish Journal of Microbiology
L Brennan, R L Heathcote, A E Lucas
A series of hypotheses on the role of the individual administrator in famine relief are proposed and three are examined with respect to case studies of famines in India (1896 and 1906-1907), Uganda (1908) and Lombok (1940). While the evidence is not conclusive, the focus upon the role of the individual administrator offers additional insights into the compexities of official response to famines.
December 1984: Disasters
M A Ali, K Mitwally, S A Ahmed
The reflectance of an absorbing medium R(theta)(ø) for incident light of an arbitrary state of polarization is considered as a function of the compex dielectic constant epsilon; ø is the angle incidence and theta is an incident polarization parameter, for which cos(2)theta and sin(2)theta give the power fractions of incident radiation that are p- and s-polarized, respectively. Our objective is to explore the complex epsilon-plane and define the domains for which the different types of R(theta)(ø) vs ø curves (monotonic, single minimum, and secondary maximum and minimum) occur...
November 1, 1990: Applied Optics
Roswitha Schmickl, Marte H Jørgensen, Anne K Brysting, Marcus A Koch
BACKGROUND: The genomes of higher plants are, on the majority, polyploid, and hybridisation is more frequent in plants than in animals. Both polyploidisation and hybridisation contribute to increased variability within species, and may transfer adaptations between species in a changing environment. Studying these aspects of evolution within a diversified species complex could help to clarify overall spatial and temporal patterns of plant speciation. The Arabidopsis lyrata complex, which is closely related to the model plant Arabidopsis thaliana, is a perennial, outcrossing, herbaceous species complex with a circumpolar distribution in the Northern Hemisphere as well as a disjunct Central European distribution in relictual habitats...
2010: BMC Evolutionary Biology
M M Volkov, A V Smirnov, V A Dobronravov, O A Degtereva, E V Sheviakova, I Iu Panina, I I Trofimenko
The aim of the study was to identify factors related to heart valve calcification (HVC) and effect of HVC on intracardiac hemodynamics in patients with chronic kidney disease (CKD). 377 CKD patients of the control group and 132 ones treated by hemodialysis (HD) were examined using echocardiography, cardiomonitoring, measurement of the carotid intima-media thickness and mineral bone density, X-ray imaging of calcified abdominal aorta. HVC was diagnosed in 38.9 and 27.3% of the CKD patients on hemodialysis and without it respectively...
2009: Klinicheskaia Meditsina
Urszula Stolarska, Sławomir Kroczka, Aleksandra Gergont, Małgorzata Steczkowska, Marek Kaciński
INTRODUCTION: The Verbal Fluency Test is one of the easiest method in the neuropsychological evaluation of the frontal and temporal lobes' functioning. The amount of reasearch considering children's performance is still small compared to the adult population. The test lacks polish norms (as well as norms for children in other countries, except for unique cases). AIM OF THE STUDY: it was to present possible methods of quality and quantity analysis of the Verbal Fluency Test, and the statistical interpretation of children's performance, depending on the general result, age and diagnosis...
2008: Przegla̧d Lekarski
Milos R Popovic
Key to a successful application of functional electrical stimulation as a rehabilitation therapy (also termed functional electrical therapy or FET) is modular, portable, programmable, and versatile transcutaneous electrical stimulation technology. In this article a hardware platform, Compex Motion, that has been used successfully to develop numerous FET systems for walking, reaching and grasping is presented. The Compex Motion stimulator can be programmed to generate any arbitrary stimulation sequence, which can be controlled or regulated using any external sensor or sensory system...
2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jolanta Wilmańska, Ewa Gułaj
BACKGROUND: More then half of elderly adults over 60 years old suffer from arthrosis. Pain and mobility reduction associated with this disease, reduce elderly peoples independence and are the reason of their physical disability. The aim of this study was to estimate coincidence of arthrosis and depression in population of outpatients of Geriatric Clinic and to asses the influence of each disease on functional ability, pain and selfhealth evaluation. Furthermore we tried to evaluate a relationship between age, sex, education, financial position, self-evaluation of health condition with presence of arthrosis...
December 29, 2006: Ortopedia, Traumatologia, Rehabilitacja
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