Haojun Liang, Kui Chen, Jing Xie, Lei Yao, Yunpeng Liu, Fan Hu, Hao Li, Yinze Lei, Yujiao Wang, Linwen Lv, Ziteng Chen, Sen Liu, Qiuyang Liu, Zhijie Wang, Jiacheng Li, Ya-Nan Chang, Juan Li, Hui Yuan, Gengyan Xing, Gengmei Xing
Improving local bone mineral density (BMD) at fracture-prone sites of bone is a clinical concern for osteoporotic fracture prevention. In this study, a featured radial extracorporeal shock wave (rESW) responsive nano-drug delivery system (NDDS) is developed for local treatment. Based on a mechanic simulation, a sequence of hollow zoledronic acid (ZOL)-contained nanoparticles (HZNs) with controllable shell thickness that predicts various mechanical responsive properties is constructed by controlling the deposition time of ZOL and Ca2+ on liposome templates...
March 27, 2023: Small