keyword
https://read.qxmd.com/read/38532029/author-correction-genotype-stratified-treatment-for-monogenic-insulin-resistance-a-systematic-review
#21
Robert K Semple, Kashyap A Patel, Sungyoung Auh, Rebecca J Brown
No abstract text is available yet for this article.
March 26, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38531652/structural-and-functional-effects-of-inosine-modification-in-mrna
#22
JOURNAL ARTICLE
Herra G Mendoza, Peter A Beal
Inosine (I), resulting from the deamination of adenosine (A), is a prominent modification in the human transcriptome. The enzymes responsible for the conversion of adenosine to inosine in human mRNAs are the ADARs (adenosine deaminases acting on RNA). Inosine modification introduces a layer of complexity to mRNA processing and function, as it can impact various aspects of RNA biology, including mRNA stability, splicing, translation, and protein binding. The relevance of this process is emphasized in the growing number of human disorders associated with dysregulated A-to-I editing pathways...
March 26, 2024: RNA
https://read.qxmd.com/read/38531651/adenosine-deaminases-that-act-on-rna-then-and-now
#23
JOURNAL ARTICLE
Brenda L Bass
In this article I recount my memories of key experiments that led to my entry into the RNA editing/modification field. I highlight initial observations made by the pioneers in the ADAR field, and how they fit into our current understanding of this family of enzymes. I discuss early mysteries that have now been solved, as well as those that still linger. Finally, I discuss important, outstanding questions and acknowledge my hope for the future of the RNA editing/modification field.
March 26, 2024: RNA
https://read.qxmd.com/read/38531431/triterpenes-g-a-and-g-e-from-galphimia-glauca-with-anti-inflammatory-and-anti-arthritic-activity-in-mice
#24
JOURNAL ARTICLE
Santillan-Urquiza Mayra Alejandra, Pérez Salud, Vega-Avila Elisa, Jiménez-Ferrer Enrique, Rendón-Martínez Julissa, Tortoriello Jaime, Zamilpa Alejandro, Salinas-Sánchez David, Maribel Herrera-Ruiz
ETHNOPHARMACOLOGICAL RELEVANCE: Galphimia glauca is a medicinal plant that treats inflammatory and anti-rheumatic problems. Its anti-inflammatory capacity has been reported pharmacologically, attributed to the triterpenes G-A and G-E. AIM: The objective of the present work was to measure the anti-inflammatory and immunomodulatory effect of the methanolic extract (GgMeOH) of Galphimia glauca and the isolated galphimines G-A and G-E, first in an acute test of plantar edema with carrageenan, and later in the model of experimental-induced arthritis with CFA...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38529328/the-americans-with-disabilities-act-and-equal-access-to-public-spaces
#25
JOURNAL ARTICLE
Barry A Whaley, Jonathan G Martinis, Giuseppe F Pagano, Sara Barthol, Jessica Senzer, Pamela R Williamson, Peter D Blanck
Since the passage of the landmark Americans with Disabilities Act of 1990, the United States federal government, states, and localities have passed laws and created policies intended to ensure that people with disabilities had full and equal access to public spaces. Nevertheless, more than three decades after the ADA, people with disabilities continue to face architectural and other barriers to community inclusion and participation. This article describes laws, policies, and initiatives that are implemented in the United States at the federal, state, and local levels to address these barriers, examines their effectiveness, and describes the views of advocates working in furtherance of the rights of people with disabilities and the inclusiveness of public spaces...
2024: Laws
https://read.qxmd.com/read/38526670/machine-learning-aided-search-for-ligands-of-p2y-6-and-other-p2y-receptors
#26
JOURNAL ARTICLE
Ana C Puhl, Sarah A Lewicki, Zhan-Guo Gao, Asmita Pramanik, Vadim Makarov, Sean Ekins, Kenneth A Jacobson
The P2Y6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders, yet few potent and selective antagonists are known to date. This prompted us to use machine learning as a novel approach to aid ligand discovery, with pharmacological evaluation at three P2YR subtypes: initially P2Y6 and subsequently P2Y1 and P2Y14 . Relying on extensive published data for P2Y6 R agonists, we generated and validated an array of classification machine learning model using the algorithms deep learning (DL), adaboost classifier (ada), Bernoulli NB (bnb), k-nearest neighbors (kNN) classifier, logistic regression (lreg), random forest classifier (rf), support vector classification (SVC), and XGBoost (XGB) classifier models, and the common consensus was applied to molecular selection of 21 diverse structures...
March 25, 2024: Purinergic Signalling
https://read.qxmd.com/read/38524700/nucleoside-deaminases-the-key-players-in-base-editing-toolkit
#27
JOURNAL ARTICLE
Jiangchao Xiang, Wenchao Xu, Jing Wu, Yaxin Luo, Bei Yang, Jia Chen
The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision. Such nucleoside deaminases include adenosine and cytidine deaminases, which can catalyze adenosine-to-inosine (A-to-I) and cytidine-to-uridine (C-to-U) conversion respectively. These nucleoside deaminases are under the spotlight because of their vast application potential in gene editing. Recent advances in the engineering of current nucleoside deaminases and the discovery of new nucleoside deaminases greatly broaden the application scope and improve the editing specificity of base editors...
December 31, 2023: Biophysics Reports
https://read.qxmd.com/read/38524199/comparison-of-efficacy-and-adherence-of-patient-preferred-1-unit-daily-and-ada-easd-guideline-recommended-2-units-every-3-days-basal-insulin-titration-algorithms-multicenter-randomized-clinical-study
#28
JOURNAL ARTICLE
Ling Li, Xiaodan Zhang, Tong Zhang, Liankun Zeng, Mingrun Lin, Yanli Li, Wangen Li
AIM: Insulin titration often faces inertia, hindering glycemic control. A patient-centered approach empowers patients to overcome this inertia. This study aims to compare the effectiveness of patient-preferred and guideline-recommended self-titration algorithms in achieving glycemic targets and improving adherence. METHODS: Outpatients with type 2 diabetes (T2D) who did not respond to oral antihyperglycemic drugs (OAD) were assessed. They were randomly assigned to patient-preferred and guideline-recommended groups...
2024: Patient Preference and Adherence
https://read.qxmd.com/read/38523059/iclamp-a-novel-technique-to-explore-adenosine-deamination-via-inosine-chemical-labeling-and-affinity-molecular-purification
#29
JOURNAL ARTICLE
Yuxi Yang, Koki Nakayama, Shunpei Okada, Kazuki Sato, Takeshi Wada, Yuriko Sakaguchi, Ayaka Murayama, Tsutomu Suzuki, Masayuki Sakurai
Recent developments in sequencing and bioinformatics have advanced our understanding of adenosine-to-inosine (A-to-I) RNA editing. Surprisingly, recent analyses have revealed the capability of adenosine deaminase acting on RNA (ADAR) to edit DNA:RNA hybrid strands. However, edited inosines in DNA remain largely unexplored. A precise biochemical method could help uncover these potentially rare DNA editing sites. We explore maleimide as a scaffold for inosine labeling. With fluorophore-conjugated maleimide, we were able to label inosine in RNA or DNA...
March 24, 2024: FEBS Letters
https://read.qxmd.com/read/38521874/comparing-achievement-of-national-psoriasis-foundation-treatment-targets-among-patients-with-plaque-psoriasis-treated-with-ixekizumab-versus-other-biologics-in-clinical-and-real-world-studies
#30
JOURNAL ARTICLE
April Armstrong, Alvaro González-Cantero, Saakshi Khattri, Guilherme Muzy, William N Malatestinic, Anastasia Lampropoulou, Meghan Feely, Sophia Kyoungah See, Can Mert, Andrew Blauvelt
INTRODUCTION: The National Psoriasis Foundation (NPF) recommends evaluating patient response to treatment at week 12, with a target response of ≤ 1% body surface area (BSA) affected by plaque psoriasis and an acceptable response of BSA ≤ 3% or ≥ 75% improvement. This post hoc analysis compared the achievement of NPF target and acceptable responses for ixekizumab (IXE) versus other biologics. METHODS: Outcomes were evaluated at week 12 for patients with moderate-to-severe plaque psoriasis from four head-to-head randomized clinical trials (RCTs; UNCOVER-2, UNCOVER-3, IXORA-R, and IXORA-S) and one real-world prospective observational study (Psoriasis Study of Health Outcomes; PSoHO)...
March 23, 2024: Dermatology and Therapy
https://read.qxmd.com/read/38519817/a-high-threshold-of-biotherapeutic-aggregate-numbers-is-needed-to-induce-an-immunogenic-response-in-vitro-in-vivo-and-in-the-clinic
#31
JOURNAL ARTICLE
Joseph R Cohen, Stephen R Brych, Siddharth Prabhu, Vivian Bi, Ahmed Elbaradei, Joshua M Tokuda, Cathie Xiang, Martha Hokom, Xiaohong Cui, Claudia Ly, Nathan Amos, Jilin Sun, Dominador Calamba, Jonathan Herskovitz, Allyson Capili, Kimya Nourbakhsh, Anthony Merlo, Julia Carreon, Jette Wypych, Linda O Narhi, Vibha Jawa, Marisa K Joubert
BACKGROUND AND PURPOSE: There is concern that subvisible aggregates in biotherapeutic drug products pose a risk to patient safety. We investigated the threshold of biotherapeutic aggregates needed to induce immunogenic responses. METHODS AND RESULTS: Highly aggregated samples were tested in cell-based assays and induced cellular responses in a manner that depended on the number of particles. The threshold of immune activation varied by disease state (cancer, rheumatoid arthritis, allergy), concomitant therapies, and particle number...
March 22, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38519399/adavosertib-encapsulated-metal-organic-frameworks-for-p53-mutated-gallbladder-cancer-treatment-via-synthetic-lethality
#32
JOURNAL ARTICLE
Shijie Li, Sarun Juengpanich, Win Topatana, Tianao Xie, Lidan Hou, Yiyuan Zhu, Jiadong Chen, Yukai Shan, Yina Han, Ziyi Lu, Tianen Chen, Charlie Topatana, Bin Zhang, Jiasheng Cao, Jiahao Hu, Jiafei Yan, Yingxin Chen, Zhen Gu, Jicheng Yu, Xiujun Cai, Mingyu Chen
Adavosertib (ADA) is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer (GBC). However, drug resistance due to DNA damage response compensation pathways and high toxicity limits further applications. Herein, estrone-targeted ADA-encapsulated metal-organic frameworks (ADA@MOF-EPL) for GBC synthetic lethal treatment by inducing conditional factors are developed. The high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor microenvironment...
February 29, 2024: Science Bulletin
https://read.qxmd.com/read/38517760/society-for-ambulatory-anesthesia-updated-consensus-statement-on-perioperative-blood-glucose-management-in-adult-patients-with-diabetes-mellitus-undergoing-ambulatory-surgery
#33
JOURNAL ARTICLE
Niraja Rajan, Elizabeth W Duggan, Basem B Abdelmalak, Steven Butz, Leopoldo V Rodriguez, Mary Ann Vann, Girish P Joshi
WHAT OTHER GUIDELINES ARE AVAILABLE ON THIS TOPIC: Since the publication of the SAMBA Consensus Statement for perioperative blood glucose management in the ambulatory setting in 2010, several recent guidelines have been issued by the American Diabetes Association (ADA), the American Association of Clinical Endocrinologists (AACE), the Endocrine Society, the Centre for Perioperative Care (CPOC), and the Association of Anaesthetists of Great Britain and Ireland (AAGBI) on DM care in hospitalized patients; however, none are specific to ambulatory surgery...
March 22, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38516789/prevalence-estimates-of-tuberculosis-infection-in-adults-in-denmark-a-retrospective-nationwide-register-based-cross-sectional-study-2010-to-2018
#34
JOURNAL ARTICLE
Anne Ahrens Østergaard, Troels Lillebaek, Inge Petersen, Andreas Fløe, Eliza H Worren Bøkan, Ole Hilberg, Inge K Holden, Lone Larsen, Ada Colic, Christian Wejse, Pernille Ravn, Bente Mertz Nørgård, Stephanie Bjerrum, Isik Somuncu Johansen
BackgroundTuberculosis (TB) elimination requires identifying and treating persons with TB infection (TBI).AimWe estimate the prevalence of positive interferon gamma release assay (IGRA) tests (including TB) and TBI (excluding TB) in Denmark based on TBI screening data from patients with inflammatory bowel disease (IBD) or inflammatory rheumatic disease (IRD).MethodsUsing nationwide Danish registries, we included all patients with IBD or IRD with an IGRA test performed between 2010 and 2018. We estimated the prevalence of TBI and positive IGRA with 95% confidence intervals (CI) in adolescents and adults aged 15-64 years after sample weighting adjusting for distortions in the sample from the background population of Denmark for sex, age group and TB incidence rates (IR) in country of birth...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38516355/case-report-profound-newborn-leukopenia-related-to-a-novel-rac2-variant
#35
Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J Kim-Chang, Paul L Martin, Amy P Stallings, John W Sleasman, Steven M Holland, Amy P Hsu, Thomas L Leto, Talal Mousallem
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and Escherichia coli bacteremia. He did not pass early confirmatory hearing screens. Initial blood counts and lymphocyte flow cytometry revealed profound neutropenia and lymphopenia with a T-/B-/NK- phenotype. Red blood cell adenosine deaminase 1 activity was within normal limits. A presumptive diagnosis of reticular dysgenesis was considered...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38515770/successful-embolization-of-an-anterior-chest-wall-arteriovenous-malformation-using-combined-transfemoral-and-transradial-approaches-with-onyx
#36
Islam M Rajab, Abdelkarim Adas, Abdalhakim R M Shubietah, Mohammed I Khader
We present a case of successful embolization of an anterior chest wall arteriovenous malformation (AVM) in a 24-year-old male patient. This report aims to highlight the efficacy and safety of using the liquid embolic agent (onyx) as well as the combined approaches (trans-femoral and trans-radial) in managing rare complex chest wall AVMs.
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38515728/comparison-of-three-vst-orthokeratology-lenses-in-axial-length-growth-and-average-corneal-reshaping-in-myopia-children-a-retrospective-self-controlled-study
#37
JOURNAL ARTICLE
Anken Wang, Wansheng Zang, Li Shen, Lu Gao, Chenhao Yang
PURPOSE: To determine the differences in myopia control efficiency and corneal reshaping between three different brands of orthokeratology (OK) lenses (Lucid, Euclid, and Alpha). METHOD: We retrospectively reviewed subjects who started simultaneously using different brands of OK lenses. For each participant, every 6 months in the 19 months of following, the changes in axial length (AL), horizontal and vertical maximum distances of the treatment zone (HMDTZ and VMDTZ), width of the high convex zone (WHCZ), distance of decentration, and horizontal and vertical components of the decentration vector were measured...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515445/safety-tolerability-and-efficacy-estimate-of-evoked-gamma-oscillation-in-mild-to-moderate-alzheimer-s-disease
#38
JOURNAL ARTICLE
Mihály Hajós, Alyssa Boasso, Evan Hempel, Monika Shpokayte, Alex Konisky, Chandran V Seshagiri, Vitella Fomenko, Kim Kwan, Jessie Nicodemus-Johnson, Suzanne Hendrix, Brent Vaughan, Ralph Kern, Jonathan T Megerian, Zach Malchano
BACKGROUND: Alzheimer's Disease (AD) is a multifactorial, progressive neurodegenerative disease that disrupts synaptic and neuronal activity and network oscillations. It is characterized by neuronal loss, brain atrophy and a decline in cognitive and functional abilities. Cognito's Evoked Gamma Therapy System provides an innovative approach for AD by inducing EEG-verified gamma oscillations through sensory stimulation. Prior research has shown promising disease-modifying effects in experimental AD models...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38515012/development-and-validation-of-cognitive-ageing-risk-score-cars-for-early-detection-of-subtle-cognitive-deficits-in-older-people
#39
JOURNAL ARTICLE
Ada Wai Tung Fung, Allen Ting Chun Lee, Suk Ling Ma, Linda Chiu Wa Lam
BACKGROUND: Early cognitive deficits commonly seen in older people have not been well defined and managed in primary care. The objectives are (1) to develop and validate a new risk score to estimate the risk of dementia in Chinese older population; and (2) to evaluate the use of risk score in conjunction with cognitive screening in detecting early cognitive deficits in community older people. METHODS: A development cohort of 306 cognitive healthy older adults aged 60 or above were followed for 6 years...
March 21, 2024: BMC Geriatrics
https://read.qxmd.com/read/38514757/paper-based-electrochemical-device-for-early-detection-of-integrin-%C3%AE-v%C3%AE-6-expressing-tumors
#40
JOURNAL ARTICLE
Stefano Cinti, Stefano Tomassi, Chiara Ciardiello, Rossella Migliorino, Marinella Pirozzi, Alessandra Leone, Elena Di Gennaro, Virginia Campani, Giuseppe De Rosa, Vincenzo Maria D'Amore, Salvatore Di Maro, Greta Donati, Sima Singh, Ada Raucci, Francesco Saverio Di Leva, Horst Kessler, Alfredo Budillon, Luciana Marinelli
Despite progress in the prevention and diagnosis of cancer, current technologies for tumor detection present several limitations including invasiveness, toxicity, inaccuracy, lengthy testing duration and high cost. Therefore, innovative diagnostic techniques that integrate knowledge from biology, oncology, medicinal and analytical chemistry are now quickly emerging in the attempt to address these issues. Following this approach, here we developed a paper-based electrochemical device for detecting cancer-derived Small Extracellular Vesicles (S-EVs) in fluids...
March 21, 2024: Communications Chemistry
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