keyword
MENU ▼
Read by QxMD icon Read
search

ADA

keyword
https://www.readbyqxmd.com/read/29781767/activities-of-purine-converting-enzymes-in-heart-liver-and-kidney-mice-ldlr-and-apo-e
#1
I M Rybakowska, B Kutryb-Zając, R Milczarek, B Łukasz, E M Slominska, R T Smolenski
Nucleotide metabolism plays a major role in a number of vital cellular processes such as energetics. This, in turn, is important in pathologies such as atherosclerosis. Three month old atherosclerotic mice with knock outs for LDLR and apolipoprotein E (ApoE) were used for the experiments. Activities of AMP-deaminase (AMPD), ecto5'-nucleotidase (e5NT), adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) were measured in heart, liver and kidney cortex and medulla by analysing conversion of substrates into products using HPLC...
May 21, 2018: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29779958/development-of-an-anti-epo-antibody-detection-kit-based-on-lab-on-a-chip-and-bridging-antibody-technologies
#2
Jin-Gyo Oh, Jihyun Seong, Sunmi Han, Tae-Hwe Heo
Immunogenicity is a major concern in the use of biological drugs. In particular, antibody-mediated pure red cell aplasia (PRCA) is a rare condition that is caused by administration of recombinant erythropoietin. There are numerous assay platforms for detect EPO anti-drug antibody (ADA), and most have appropriate assay sensitivity, but in need of improvement in terms of assay turnaround time and user accessibility. Here, the new method was developed based on lab-on-a-chip technology and bridging ELISA. The FREND™ Cartridge is equipped with a microfluidic lateral flow channel, enabling easy, fast and accurate immunoassays with small sample volumes...
May 17, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29776901/a-moderated-e-forum-for-adults-with-cardiovascular-disease-usability-study
#3
Rika Tanaka, Anita Banerjee, Jelena Surikova, Jacqueline Tracey, Ada Payne, Heather Ross, Robert Nolan
BACKGROUND: Self-care behaviors are commonly prescribed to manage both cardiovascular disease and hypertension to reduce modifiable risk factors and improve quality of life. Nevertheless, long-term adherence to self-care recommendations for cardiac patients has been problematic. In cardiac patients, moderated online forums have been found to be particularly useful in supporting maintenance of heart-healthy diet and fewer hospital visits. As such, we developed the e-Forum, a Web-based moderated forum designed to promote continued user engagement and long-term self-care adherence...
May 18, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29776602/blurring-boundaries-receptor-tyrosine-kinases-as-functional-g-protein-coupled-receptors
#4
Caitrin Crudden, Takashi Shibano, Dawei Song, Naida Suleymanova, Ada Girnita, Leonard Girnita
Receptor tyrosine kinases (RTKs) such as the insulin-like growth factor type 1 receptor (IGF-1R) control important biological activities as well as being involved in pathological processes. Due to their supportive nature in many human cancers they have long been considered attractive therapeutic targets. However, lessons learnt from early targeting trials highlight that a simple "active versus inactive" state model with classical kinase-only signaling is overly simplistic and does not describe reality...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29771462/different-neural-activities-support-auditory-working-memory-in-musicians-and-bilinguals
#5
Claude Alain, Yasha Khatamian, Yu He, Yunjo Lee, Sylvain Moreno, Ada W S Leung, Ellen Bialystok
Musical training and bilingualism benefit executive functioning and working memory (WM)-however, the brain networks supporting this advantage are not well specified. Here, we used functional magnetic resonance imaging and the n-back task to assess WM for spatial (sound location) and nonspatial (sound category) auditory information in musician monolingual (musicians), nonmusician bilinguals (bilinguals), and nonmusician monolinguals (controls). Musicians outperformed bilinguals and controls on the nonspatial WM task...
May 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29771301/anti-tnf-levels-in-cord-blood-at-birth-are-associated-with-anti-tnf-type
#6
Shannon L Kanis, Alison de Lima, Cokkie van der Ent, Dimitris Rizopoulos, C Janneke van der Woude
Background and Aims: Pregnancy guidelines for women with Inflammatory Bowel Disease (IBD) provide recommendations regarding anti-TNF cessation during pregnancy, in order to limit fetal exposure. Although infliximab (IFX) leads to higher anti-TNF concentrations in cord blood than adalimumab (ADA), recommendations are similar. We aimed to demonstrate the effect of anti-TNF cessation during pregnancy on fetal exposure, for IFX and ADA separately. Methods: We conducted a prospective single center cohort study...
May 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29769247/dementia-and-physical-activity-dapa-trial-of-moderate-to-high-intensity-exercise-training-for-people-with-dementia-randomised-controlled-trial
#7
Sarah E Lamb, Bart Sheehan, Nicky Atherton, Vivien Nichols, Helen Collins, Dipesh Mistry, Sukhdeep Dosanjh, Anne Marie Slowther, Iftekhar Khan, Stavros Petrou, Ranjit Lall
OBJECTIVE: To estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia. DESIGN: Multicentre, pragmatic, investigator masked, randomised controlled trial. SETTING: National Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions. PARTICIPANTS: 494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care...
May 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29768618/case-resolving-capacity-of-dental-care-of-the-unified-health-system-the-perception-of-users-in-a-city-in-the-state-of-s%C3%A3-o-paulo-brazil
#8
Arinilson Moreira Chaves Lima, Cléa Adas Saliba Garbin, José Eduardo Corrente, Nemre Adas Saliba, Suzely Adas Saliba Moimaz
The aim of this study was to learn about the users' perceptions concerning the case-resolving capacity of dental care in the Unified Health System and to analyze the associations between solving capacity and both sociodemographic characteristics and access to the service. This was a cross-sectional study with a quantitative approach, in which 461 users responded to individual interviews. The outcome variable was the case-resolving capacity of dental care, obtained through the question: "In your opinion, is the dentist of this health center managing to solve all your oral health problems (Yes/No)"...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768593/-musculoskeletal-pain-among-bus-drivers-and-fare-collectors-in-the-metropolitan-region-of-belo-horizonte-brazil
#9
Mariana Roberta Lopes Simões, Ada Ávila Assunção, Adriane Mesquita de Medeiros
Musculoskeletal pain among professionals in the transport sector has been linked to working conditions. The scope of this study was to assess the prevalence of cervical musculoskeletal pain and its relation to pain in other areas (arms, hands and shoulders). The association between neck pain, related to pain in other areas or otherwise, was checked against occupational factors. A cross-sectional, descriptive and analytical study was conducted with 799 bus drivers and 708 fare collectors of the Metropolitan Region of Belo Horizonte, Brazil...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29766375/efficacy-of-adalimumab-and-infliximab-in-recalcitrant-retinal-vasculitis-inadequately-responsive-to-other-immunomodulatory-therapies
#10
Claudia Fabiani, Jurgen Sota, Donato Rigante, Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Silvana Guerriero, Alice Bitossi, Ida Orlando, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
The primary aim of the study was to evaluate the efficacy of tumor necrosis factor (TNF)-α blockers adalimumab (ADA) and infliximab (IFX) in refractory sight-threatening retinal vasculitis (RV) during a 12-month follow-up period. Secondary aims were to evaluate (i) any impact of concomitant conventional disease-modifying anti-rheumatic drugs (cDMARDs) and different lines of biologic therapy; (ii) any difference in terms of efficacy between ADA and IFX; (iii) consequences of biotherapies on the best-corrected visual acuity (BCVA); (iv) corticosteroid-sparing effect; and (vi) ocular complications during anti-TNF-α treatment...
May 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29764871/balance-and-mobility-training-at-home-using-wii-fit-in-children-with-cerebral-palsy-a-feasibility-study
#11
Hsiu-Ching Chiu, Louise Ada, Shin-Da Lee
OBJECTIVES: To investigate whether balance and mobility training at home using Wii Fit is feasible and can provide clinical benefits. DESIGN: Single-group, pre-post intervention study. SETTING: Participants' home. PARTICIPANTS: 20 children with cerebral palsy (6-12 years). INTERVENTION: Participants undertook 8 weeks of home-based Wii Fit training in addition to usual care. MAIN MEASURES: Feasibility was determined by adherence, performance, acceptability and safety...
May 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29761619/changes-in-diabetes-medication-regimens-and-glycemic-control-in-adolescents-and-young-adults-with-youth-onset-type-2-diabetes-the-search-for-diabetes-in-youth-study
#12
Cathy Anne Pinto, Jeanette M Stafford, Tongtong Wang, R Ravi Shankar, Jean M Lawrence, Grace Kim, Catherine Pihoker, Ralph B D'Agostino, Dana Dabelea
OBJECTIVE: The aim of the study was to describe recent medication patterns and changes in medication patterns and glycemic control in adolescents and young adults with incident type 2 diabetes (T2D). METHODS: Using data from the SEARCH for Diabetes in Youth Study, we conducted a cross-sectional analysis of treatments for adolescents and young adults with incident T2D in two periods (2002-2005 vs. 2008/2012), and a longitudinal analysis of medications and glycemic control for a subset with baseline and follow-up visits...
May 15, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29760157/methyl-cpg-binding-protein-2-mediates-antifibrotic-effects-in-scleroderma-fibroblasts
#13
Ye He, Pei-Suen Tsou, Dinesh Khanna, Amr H Sawalha
OBJECTIVE: Emerging evidence supports a role for epigenetic regulation in the pathogenesis of scleroderma (SSc). We aimed to assess the role of methyl-CpG-binding protein 2 (MeCP2), a key epigenetic regulator, in fibroblast activation and fibrosis in SSc. METHODS: Dermal fibroblasts were isolated from patients with diffuse cutaneous SSc (dcSSc) and from healthy controls. MeCP2 expression was measured by qPCR and western blot. Myofibroblast differentiation was evaluated by gel contraction assay in vitro...
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760053/size-tagged-preferred-ends-in-maternal-plasma-dna-shed-light-on-the-production-mechanism-and-show-utility-in-noninvasive-prenatal-testing
#14
Kun Sun, Peiyong Jiang, Ada I C Wong, Yvonne K Y Cheng, Suk Hang Cheng, Haiqiang Zhang, K C Allen Chan, Tak Y Leung, Rossa W K Chiu, Y M Dennis Lo
Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific preferred end sites in plasma DNA of pregnant women. In this study, we performed integrative analysis of preferred end sites with the size characteristics of plasma DNA fragments. We mined the preferred end sites in short and long plasma DNA molecules separately and found that these "size-tagged" ends showed improved accuracy in fetal DNA fraction estimation and enhanced noninvasive fetal trisomy 21 testing...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29757711/misleading-health-consumers-through-violations-of-communicative-norms-a-case-study-of-online-diabetes-education
#15
Derek Powell, Martin Keil, Dru Brenner, Liliana Lim, Ellen M Markman
Communication is a cooperative endeavor that goes well beyond decoding sentences' literal meaning. Listeners actively construe the meaning of utterances from both their literal meanings and the pragmatic principles that govern communication. When communicators make pragmatically infelicitous statements, the effects can be similar to paltering-misleading speech that evokes false inferences from true statements. The American Diabetes Association's (ADA's) "Diabetes Myths" website provides a real-world case study in such misleading communications...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29757076/economic-evaluation-of-concussion-programs-in-the-state-of-idaho-the-collective-potential-of-prevention-and-clinical-care
#16
Susie Bergeron, Hilary Flint, Zeynep Hansen
Concussion, or mild traumatic brain injury, especially among young children, teenagers, and young adults, is a significant problem in Ada County, Idaho, and the United States. Although much has been learned about concussion, considerable controversy and gaps in knowledge still exist in many areas of research, leading to variation in concussion assessment, treatment, and management protocols. Health systems can positively impact concussion outcomes through community education and outreach, and provision of timely, coordinated, evidence-based clinical care...
May 14, 2018: Population Health Management
https://www.readbyqxmd.com/read/29753681/quality-of-plasma-samples-and-bd-vacutainer-barricor-tubes-effects-of-centrifugation
#17
Andrea Padoan, Martina Zaninotto, Elisa Piva, Laura Sciacovelli, Ada Aita, Adriano Tasinato, Mario Plebani
BACKGROUNDS: The BD Vacutainer ® Barricor™ Plasma collection tube (BD Barricors) uses an innovative non-gel separation method. This study compared the plasma residual cell count (PRCC) obtained from BD Barricor and from BD PST II plasma tubes. METHODS: Four BD Barricors and one BD PST II were collected from 40 donors. BD PST II was centrifuged at 1300g/10 min, while the BD Barricors were centrifuged at 1800g/10 min, 4000g/3 min, 4000g/7 min and 4000g/15 min...
May 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29752254/cognitive-assessment-of-patients-with-alzheimer-s-disease-by-telemedicine-pilot-study
#18
Anna Carotenuto, Raffaele Rea, Enea Traini, Giovanna Ricci, Angiola Maria Fasanaro, Francesco Amenta
BACKGROUND: Approximately 46.8 million people are living with dementia worldwide and their number will grow in the next years. Any potential treatment should be administered as early as possible because it is important to provide an early cognitive assessment and to regularly monitor the mental function of patients. Information and communication technologies can be helpful to reach and follow patients without displacing them, but there may be doubts about the reliability of cognitive tests performed by telemedicine...
May 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29751001/ixekizumab-pharmacokinetics-anti-drug-antibodies-and-efficacy-through-60-weeks-of-treatment-of-moderate-to-severe-plaque-psoriasis
#19
Kristian Reich, Kimberley Jackson, Susan Ball, Sandra Garces, Lisa Kerr, Laiyi Chua, Talia M Muram, Andrew Blauvelt
Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, is efficacious for moderate-to-severe plaque psoriasis. We examined relationships between serum ixekizumab concentrations, treatment-emergent anti-drug antibodies (TE-ADA), and efficacy during 60 weeks of treatment in a randomized, controlled, phase 3 study. Steady-state ixekizumab serum trough concentrations were rapidly achieved and associated with high clinical responses at week 12 with a starting dose of 160 mg followed by 80 mg every 2 weeks...
May 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29749935/improvement-of-reverse-remodeling-using-electrocardiogram-fusion-optimized-intervals-in-cardiac-resynchronization-therapy-a-randomized-study
#20
Emilce Trucco, José María Tolosana, Elena Arbelo, Ada Doltra, María Ángeles Castel, Eva Benito, Roger Borràs, Eduard Guasch, Silvia Vidorreta, Barbara Vidal, Silvia Montserrat, Marta Sitges, Antonio Berruezo, Josep Brugada, Lluís Mont
OBJECTIVES: The aim of this study was to compare patient response to cardiac resynchronization therapy (CRT) using fusion-optimized atrioventricular (AV) and interventricular (VV) intervals versus nominal settings. BACKGROUND: The additional benefit obtained by AV- and VV-interval optimization in patients undergoing CRT remains controversial. Previous studies show short-term benefit in hemodynamic parameters; however, midterm randomized comparison between electrocardiogram optimization and nominal parameters is lacking...
February 2018: JACC. Clinical Electrophysiology
keyword
keyword
37764
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"