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JOURNAL ARTICLE
Sepideh Mehravar, Gabriela S Leite, Mark Pimentel, Ali Rezaie
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most commonly used echinocandins, were evaluated in various in vitro environments simulating intestinal lumen. The results revealed that while both antifungals are effective in standard medium, their efficacy significantly diminishes in the presence of human small bowel aspirates and bovine bile...
2024: Frontiers in Pharmacology
#2
JOURNAL ARTICLE
Gabriela Leite, Gillian M Barlow, Mohamad Rashid, Ava Hosseini, Daniel Cohrs, Gonzalo Parodi, Walter Morales, Stacy Weitsman, Ali Rezaie, Mark Pimentel, Ruchi Mathur
OBJECTIVES: Gut microbiome changes are linked to obesity, but findings are based on stool data. Here, we analyzed the duodenal microbiome and serum biomarkers in subjects with normal weight, overweight, and obesity. METHODS: Duodenal aspirates and serum samples were obtained from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation. Aspirate DNAs were analyzed by 16S rRNA and shotgun sequencing. Predicted microbial metabolic functions and serum levels of metabolic and inflammatory biomarkers were also assessed...
April 8, 2024: American Journal of Gastroenterology
#3
JOURNAL ARTICLE
Luz M Vidal, Emilio Pimentel, Luis Escobar-Alarcón, Martha P Cruces, Elizabeth Jiménez, Hugo Suárez, Yosary Leyva
Nanoribbons of imidacloprid, a systemic and chloronicotinyl insecticide, were successfully synthesized by laser-induced fragmentation/exfoliation of imidacloprid powders suspended in water, with widths ranging from 160 to 470 nm, lengths in the micron scale, and thickness of a few atoms layers. The aim of the present study was to examine the effects of acute and chronic exposure to imidacloprid (IMC) bulk and compare its effects with synthesized imidacloprid nanoribbons (IMCNR) on larval and adult viability, developmental time, olfactory capacity, longevity, productivity, and genotoxicity in Drosophila melanogaster ...
February 22, 2024: Journal of Toxicology and Environmental Health. Part A
#4
JOURNAL ARTICLE
Mizael Machado, Cintia R R Queiroz-Machado, Dale R Gardner, Márcio B Castro, Antônio Carlos L Câmara, Luciano A Pimentel, Glauco J N Galiza, Franklin Riet-Correa
Leucaena leucocephala poisoning is reported in horses in different Brazilian regions. The poisoning occurred one month after the horses were introduced into paddocks invaded by the plant or after 10 days of consuming cut Leucaena administered as the only food. Affected horses showed moderate to severe hair loss on the mane and tail, orthokeratotic hyperkeratosis with marked follicular telogenization, and hyperplasia of thyroid follicular cells. Mimosin concentration in leaves (5.5 mg/g) was determined by a new HLPC-UV method which is also reported...
February 19, 2024: Toxicon: Official Journal of the International Society on Toxinology
#5
Will Takakura, Ali Rezaie, William D Chey, Jiajing Wang, Mark Pimentel
BACKGROUND/AIMS: We performed a systematic review and meta-analysis evaluating the symptomatic response rate to antibiotics in patients with small intestinal bacterial overgrowth (SIBO). Similarly, we performed a meta-analysis on the symptomatic response to antibiotics in irritable bowel syndrome (IBS) patients with and without SIBO. METHODS: MEDLINE, EMBASE, Web of Science, and Cochrane databases were searched from inception to March 2021. Randomized controlled trials and prospective studies reporting dichotomous outcomes were included...
January 30, 2024: Journal of Neurogastroenterology and Motility
#6
JOURNAL ARTICLE
Ava Hosseini, Gillian M Barlow, Gabriela Leite, Mohamad Rashid, Gonzalo Parodi, Jiajing Wang, Walter Morales, Stacy Weitsman, Ali Rezaie, Mark Pimentel, Ruchi Mathur
Studies using stool samples suggest that non-sugar sweetener (NSS) consumption affects gut microbiome composition. However, stool does not represent the entire gut. We analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N = 35), aspartame only (ASP, N = 9), and controls (CON, N = 55) and the stool microbiome in a subset (N = 40). Duodenal alpha diversity was decreased in NANS vs. CON. Duodenal relative abundance (RA) of Escherichia , Klebsiella , and Salmonella (all phylum Proteobacteria) was lower in both NANS and ASP vs...
December 15, 2023: IScience
#7
JOURNAL ARTICLE
Gabriela Leite, Juliana de Freitas Germano, Walter Morales, Stacy Weitsman, Gillian M Barlow, Gonzalo Parodi, Maya L Pimentel, Maria Jesus Villanueva-Millan, Maritza Sanchez, Sarah Ayyad, Ali Rezaie, Ruchi Mathur, Mark Pimentel
Diarrhea-predominant irritable bowel syndrome (IBS-D), associated with increased intestinal permeability, inflammation, and small intestinal bacterial overgrowth, can be triggered by acute gastroenteritis. Cytolethal distending toxin B (CdtB) is produced by gastroenteritis-causing pathogens and may underlie IBS-D development, through molecular mimicry with vinculin. Here, we examine the effects of exposure to CdtB alone on gut microbiome composition, host intestinal gene expression, and IBS-D-like phenotypes in a rat model...
2024: Gut Microbes
#8
JOURNAL ARTICLE
Maria Perpétuo Socorro Sampaio Carvalho, Fábio Magalhães-Gama, Bruna Pires Loiola, Juliana Costa Ferreira Neves, Nilberto Dias Araújo, Flavio Souza Silva, Claudio Lucas Santos Catão, Eliana Brasil Alves, João Paulo Diniz Pimentel, Maria Nazaré Saunier Barbosa, Nelson Abrahim Fraiji, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Allyson Guimarães Costa, Adriana Malheiro
BACKGROUND: Children with B-cell acute lymphoblastic leukemia (B-ALL) have an immune imbalance that is marked by remodeling of the hematopoietic compartment, with effects on peripheral blood (PB). Although the bone marrow (BM) is the main maintenance site of malignancy, the frequency with which immune cells and molecules can be monitored is limited, thus the identification of biomarkers in PB becomes an alternative for monitoring the evolution of the disease. METHODS: Here, we characterize the systemic immunological profile in children undergoing treatment for B-ALL, and evaluate the performance of cell populations, chemokines and cytokines as potential biomarkers during clinical follow-up...
2023: Frontiers in Oncology
#9
JOURNAL ARTICLE
Maria J Villanueva-Millan, Gabriela Leite, Walter Morales, Maritza Sanchez, Gonzalo Parodi, Stacy Weitsman, Shreya Celly, Daniel Cohrs, Huongly Do, Gillian M Barlow, Ruchi Mathur, Ali Rezaie, Mark Pimentel
BACKGROUND: We recently demonstrated that diarrhea-predominant irritable bowel syndrome (IBS-D) subjects have higher relative abundance (RA) of hydrogen sulfide (H2 S)-producing Fusobacterium and Desulfovibrio species, and constipation-predominant IBS (IBS-C) subjects have higher RA of methanogen Methanobrevibacter smithii. AIMS: In this study, we investigate the effects of increased methanogens or H2 S producers on stool phenotypes in rat models. METHODS: Adult Sprague-Dawley rats were fed high-fat diet (HFD) for 60 days to increase M...
December 7, 2023: Digestive Diseases and Sciences
#10
JOURNAL ARTICLE
Kresten Krarup Keller, Chetan B Mukhtyar, Andreas Wiggers Nielsen, Andrea Katharina Hemmig, Sarah Louise Mackie, Sebastian Eduardo Sattui, Ellen-Margrethe Hauge, Anisha Dua, Toby Helliwell, Lorna Neill, Daniel Blockmans, Valérie Devauchelle-Pensec, Eric Hayes, Annett Jansen Venneboer, Sara Monti, Cristina Ponte, Eugenio De Miguel, Mark Matza, Kenneth J Warrington, Kevin Byram, Kinanah Yaseen, Christine Peoples, Michael Putman, Lindsay Lally, Michael Finikiotis, Simone Appenzeller, Ugo Caramori, Carlos Enrique Toro-Gutiérrez, Elisabeth Backhouse, María Camila Guerrero Oviedo, Victor Román Pimentel-Quiroz, Helen Isobel Keen, Claire Elizabeth Owen, Thomas Daikeler, Annette de Thurah, Wolfgang A Schmidt, Elisabeth Brouwer, Christian Dejaco
OBJECTIVE: To develop international consensus-based recommendations for early referral of individuals with suspected polymyalgia rheumatica (PMR). METHODS: A task force including 29 rheumatologists/internists, 4 general practitioners, 4 patients and a healthcare professional emerged from the international giant cell arteritis and PMR study group. The task force supplied clinical questions, subsequently transformed into Population, Intervention, Comparator, Outcome format...
December 1, 2023: Annals of the Rheumatic Diseases
#11
JOURNAL ARTICLE
E Contreras, M Jurado-Ezqueta, R Pimentel, L Serrano, C Hidalgo, A Jiménez, M J Polo
High amounts of phosphorus (P) in rivers come mainly from two sources: fertilizers washed off from agricultural and urban areas by runoff water (non-point sources) and urban and industrial development which are translated in P discharges from wastewater treatment plants (WWTP). This work analyses the content of P in water for nearly 40 years inquiring into the origin of the sources, based on the hypothesis of runoff generation from the detection of river streamflow increases during the P contribution episode and the previous precipitation...
November 21, 2023: Environmental Research
#12
JOURNAL ARTICLE
Ava Hosseini, Mohamad Rashid, Gabriela Leite, Gillian M Barlow, Gonzalo Parodi, Maritza Sanchez, Sarah Ayyad, Maya L Pimentel, Walter Morales, Stacy Weitsman, Mark Pimentel, Ruchi Mathur
BACKGROUND: The coronavirus disease 2019 (COVID-19) global pandemic necessitated many severe lifestyle changes, including lockdowns, social distancing, altered food consumption and exercise patterns, and extensive hygiene practices. These extensive changes may have affected the human gut microbiome, which is highly influenced by lifestyle. AIMS: To examine the potential effects of pandemic-related lifestyle changes on the metabolically relevant small bowel microbiome...
August 14, 2023: Digestive Diseases and Sciences
#13
JOURNAL ARTICLE
Martha P Cruces, Emilio Pimentel, Luz M Vidal, Elizabeth Jiménez, Hugo Suárez, Enrique Camps, Enrique Campos-González
Rapid development of nanotechnology, particularly nanoparticles of pesticides, has facilitated the transformation of traditional agriculture. However, testing their effectiveness is essential for avoiding any environmental or adverse human health risk attributed to nanoparticle-based formulations, especially insecticides. Recently, organic nanoparticles of bifenthrin, a pyrethroid insecticide, were successfully synthesized by laser ablation of solids in liquid technique, with the most probable size of 5 nm...
July 21, 2023: Journal of Toxicology and Environmental Health. Part A
#14
JOURNAL ARTICLE
Juliana R P Ferreira, Isabela D Sucupira, Gabriella M C Carvalho, Fernando F Paiva, Pedro M Pimentel-Coelho, Paulo H Rosado-de-Castro, Paulo A S Mourão, Roberto J C Fonseca
Background Intracerebral hemorrhage is the most serious complication of anticoagulant therapy but the effects of different types of oral anticoagulants on the expansion of these hemorrhages are still unclear. Clinical studies have revealed controversial results; more robust and long-term clinical evaluations are necessary to define their outcomes. An alternative is to test the effect of these drugs in experimental models of intracerebral bleeding induced in animals. Aims To test new oral anticoagulants (dabigatran etexilate, rivaroxaban, and apixaban) in an experimental model of intracerebral hemorrhage induced by collagenase injection into the brain striatum of rats...
July 2023: TH Open: Companion Journal to Thrombosis and Haemostasis
#15
JOURNAL ARTICLE
Colin A Simpfendorfer, Michael R Heithaus, Michelle R Heupel, M Aaron MacNeil, Mark Meekan, Euan Harvey, C Samantha Sherman, Leanne M Currey-Randall, Jordan S Goetze, Jeremy J Kiszka, Matthew J Rees, Conrad W Speed, Vinay Udyawer, Mark E Bond, Kathryn I Flowers, Gina M Clementi, Jasmine Valentin-Albanese, M Shiham Adam, Khadeeja Ali, Jacob Asher, Eva Aylagas, Océane Beaufort, Cecilie Benjamin, Anthony T F Bernard, Michael L Berumen, Stacy Bierwagen, Chico Birrell, Erika Bonnema, Rosalind M K Bown, Edward J Brooks, J Jed Brown, Dayne Buddo, Patrick J Burke, Camila Cáceres, Marta Cambra, Diego Cardeñosa, Jeffrey C Carrier, Sara Casareto, Jennifer E Caselle, Venkatesh Charloo, Joshua E Cinner, Thomas Claverie, Eric E G Clua, Jesse E M Cochran, Neil Cook, Jessica E Cramp, Brooke M D'Alberto, Martin de Graaf, Mareike C Dornhege, Mario Espinoza, Andy Estep, Lanya Fanovich, Naomi F Farabaugh, Daniel Fernando, Carlos E L Ferreira, Candace Y A Fields, Anna L Flam, Camilla Floros, Virginia Fourqurean, Laura Gajdzik, Laura García Barcia, Ricardo Garla, Kirk Gastrich, Lachlan George, Tommaso Giarrizzo, Rory Graham, Tristan L Guttridge, Valerie Hagan, Royale S Hardenstine, Stephen M Heck, Aaron C Henderson, Patricia Heithaus, Heidi Hertler, Mauricio Hoyos Padilla, Robert E Hueter, Rima W Jabado, Jean-Christophe Joyeux, Vanessa Jaiteh, Mohini Johnson, Stacy D Jupiter, Muslimin Kaimuddin, Devanshi Kasana, Megan Kelley, Steven T Kessel, Benedict Kiilu, Taratau Kirata, Baraka Kuguru, Fabian Kyne, Tim Langlois, Frida Lara, Jaedon Lawe, Elodie J I Lédée, Steve Lindfield, Andrea Luna-Acosta, Jade Q Maggs, B Mabel Manjaji-Matsumoto, Andrea Marshall, Lucy Martin, Daniel Mateos-Molina, Philip Matich, Erin McCombs, Ashlie McIvor, Dianne McLean, Llewelyn Meggs, Stephen Moore, Sushmita Mukherji, Ryan Murray, Stephen J Newman, Josep Nogués, Clay Obota, Domingo Ochavillo, Owen O'Shea, Kennedy E Osuka, Yannis P Papastamatiou, Nishan Perera, Bradley Peterson, Caio R Pimentel, Fabián Pina-Amargós, Hudson T Pinheiro, Alessandro Ponzo, Andhika Prasetyo, L M Sjamsul Quamar, Jessica R Quinlan, José Amorim Reis-Filho, Hector Ruiz, Alexei Ruiz-Abierno, Enric Sala, Pelayo Salinas de-León, Melita A Samoilys, William R Sample, Michelle Schärer-Umpierre, Audrey M Schlaff, Kurt Schmid, Sara N Schoen, Nikola Simpson, Adam N H Smith, Julia L Y Spaet, Lauren Sparks, Twan Stoffers, Akshay Tanna, Rubén Torres, Michael J Travers, Maurits van Zinnicq Bergmann, Laurent Vigliola, Juney Ward, Joseph D Warren, Alexandra M Watts, Colin K Wen, Elizabeth R Whitman, Aaron J Wirsing, Aljoscha Wothke, Esteban Zarza-González, Demian D Chapman
A global survey of coral reefs reveals that overfishing is driving resident shark species toward extinction, causing diversity deficits in reef elasmobranch (shark and ray) assemblages. Our species-level analysis revealed global declines of 60 to 73% for five common resident reef shark species and that individual shark species were not detected at 34 to 47% of surveyed reefs. As reefs become more shark-depleted, rays begin to dominate assemblages. Shark-dominated assemblages persist in wealthy nations with strong governance and in highly protected areas, whereas poverty, weak governance, and a lack of shark management are associated with depauperate assemblages mainly composed of rays...
June 16, 2023: Science
#16
JOURNAL ARTICLE
Gabriela Leite, Ali Rezaie, Ruchi Mathur, Gillian M Barlow, Mohamad Rashid, Ava Hosseini, Jiajing Wang, Gonzalo Parodi, Maria Jesus Villanueva-Millan, Maritza Sanchez, Walter Morales, Stacy Weitsman, Mark Pimentel
BACKGROUND AND AIMS: Despite accelerated research in small intestinal bacterial overgrowth (SIBO), questions remain regarding optimal diagnostic approaches and definitions. Here, we aim to define SIBO using small bowel culture and sequencing, identifying specific contributory microbes, in the context of gastrointestinal symptoms. METHODS: Subjects undergoing esophagogastroduodenoscopy (without colonoscopy) were recruited and completed symptom severity questionnaires...
June 12, 2023: Clinical Gastroenterology and Hepatology
#17
JOURNAL ARTICLE
Paraskevas Gkolfakis, Georgios Tziatzios, Gabriela Leite, Ioannis S Papanikolaou, Elias Xirouchakis, Ioannis G Panayiotides, Athanasios Karageorgos, Maria Jesus Millan, Ruchi Mathur, Stacy Weitsman, George D Dimitriadis, Evangelos J Giamarellos-Bourboulis, Mark Pimentel, Konstantinos Triantafyllou
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial, wide-spectrum liver disorder. Small intestinal bacterial overgrowth (SIBO) is characterized by an increase in the number and/or type of colonic bacteria in the upper gastrointestinal tract. SIBO, through energy salvage and induction of inflammation, may be a pathophysiological factor for NAFLD development and progression. AIM/METHODS: Consecutive patients with histological, biochemical, or radiological diagnosis of any stage of NAFLD (non-alcoholic fatty liver [NAFL], non-alcoholic steatohepatitis [NASH], cirrhosis) underwent upper gastrointestinal endoscopy...
March 10, 2023: Microorganisms
#18
JOURNAL ARTICLE
María Herrán, Brittany L Adler, Jamie Perin, Walter Morales, Mark Pimentel, Zsuzsanna H McMahan
OBJECTIVE: The gastrointestinal (GI) tract is commonly affected in systemic sclerosis (SSc). A positive association between antivinculin antibody levels and GI symptom severity is reported in SSc. We sought to examine whether antivinculin antibodies associate with measures of GI dysmotility and extraintestinal clinical phenotype in SSc. METHODS: A total of 88 well-characterized patients with SSc and GI disease were assayed for antivinculin antibodies by enzyme-linked immunosorbent assay...
March 23, 2023: Arthritis Care & Research
#19
JOURNAL ARTICLE
Quedyane Silva da Cruz, Marco Valério Jansen Cutrim, Taiza Pimentel Santos, Ana Karoline Duarte Dos Santos Sá, Lisana Furtado Cavalcanti-Lima
β-diversity and functional traits of phytoplankton indicators associated with environmental heterogeneity were investigated as environmental quality descriptors in coastal (CS), estuarine (ES), and limnetic (LS) sectors in a tropical river-to-sea ecosystem. Results showed that environmental heterogeneity was marked by spatial differences, contributing to biological heterogeneity. Sporadic and recurrent blooms were associated with environmental spatiotemporal variations and reflected a reduction in ES α-diversity...
March 14, 2023: Marine Environmental Research
#20
JOURNAL ARTICLE
Seung Young Kim, Jae Ho Park, Gabriela Leite, Mark Pimentel, Ali Rezaie
BACKGROUND: Interleukin (IL)-10 knockout (KO) mice, a model for inflammatory bowel disease (IBD), develop chronic enterocolitis due to an aberrant immune response to enteric antigens. Endoscopy, the gold standard for evaluation of human mucosal health, is not widely available for murine models. AIMS: To assess the natural history of left-sided colitis in IL-10 KO mice via serial endoscopies. METHODS: BALB/cJ IL-10 KO mice underwent regular endoscopic assessments from 2 up to 8 months of age...
March 17, 2023: Digestive Diseases and Sciences
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