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Mark Pimentel

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https://www.readbyqxmd.com/read/28381845/autoimmunity-as-a-potential-cause-of-post-infectious-gut-dysmotility-a-longitudinal-observation
#1
Ali Rezaie, Mark Pimentel, Erica Cohen
No abstract text is available yet for this article.
April 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28323273/hydrogen-and-methane-based-breath-testing-in-gastrointestinal-disorders-the-north-american-consensus
#2
Ali Rezaie, Michelle Buresi, Anthony Lembo, Henry Lin, Richard McCallum, Satish Rao, Max Schmulson, Miguel Valdovinos, Salam Zakko, Mark Pimentel
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research. METHODS: Pre-meeting survey questions encompassing five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting...
March 21, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28291327/mechanism-of-antibacterial-activity-via-morphology-change-of-%C3%AE-agvo3-theoretical-and-experimental-insights
#3
Regiane Cristina de Oliveira, Camila Cristina de Foggi, Mayara Mondego Teixeira, Maya Dayana Penha da Silva, Marcelo Assis, Eric Mark Francisco, Bruna Natalia Alves da Silva Pimentel, Paula Fabiana Dos Santos Pereira, Carlos Eduardo Vergani, Ana Lúcia Machado, Juan Andres, Lourdes Gracia, Elson Longo
The electronic configuration, morphology, optical features, and antibacterial activity of metastable α-AgVO3 crystals have been discussed by a conciliation and association of the results acquired by experimental procedures and first-principles calculations. The α-AgVO3 powders were synthesized using a coprecipitation method at 10, 20, and 30 °C. By using a Wulff construction for all relevant low-index surfaces [(100), (010), (001), (110), (011), (101), and (111)], the fine-tuning of the desired morphologies can be achieved by controlling the values of the surface energies, thereby lending a microscopic understanding to the experimental results...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28112540/do-different-tendons-exhibit-the-same-response-following-chronic-exposure-to-statins
#4
L P Oliveira, C P Vieira, P P Marques, E R Pimentel
Over the past few years, a number of cases of tendon injuries associated with statin therapy have been reported. In this study, we assessed whether statins can affect the extracellular matrix (ECM) of the deep digital flexor tendon (DDFT) and patellar tendon (PT). Wistar rats were assigned to groups treated with atorvastatin (A20, A80), treated with simvastatin (S20, S80), and control. Zymography, Western blotting for collagen I, non-collagenous proteins (NCP), glycosaminoglycans (GAGs), and hydroxyproline quantifications were performed...
October 4, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28002334/gender-differences-among-patients-with-primary-ankylosing-spondylitis-and-spondylitis-associated-with-psoriasis-and-inflammatory-bowel-disease-in-an-iberoamerican-spondyloarthritis-cohort
#5
MULTICENTER STUDY
Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez
The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by X or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27986795/defibrillation-thresholds-with-right-pectoral-implantable-cardioverter-defibrillators-and-impact-of-waveform-tuning-the-tilt-and-tune-trial
#6
Niraj Varma, Raymond Schaerf, Steven Kalbfleisch, Rhea Pimentel, Mark W Kroll, Ashish Oza
AIMS: Assess defibrillation thresholds (DFTs) with right active pectoral implantable cardioverter defibrillator (RICDs). Defibrillation thresholds in patients receiving RICDs are regarded as 'high' and potentially improved by waveform optimization (tuning). However, this has not been systematically tested. METHODS AND RESULTS: Patients receiving RICDs [Single chamber (VVI) = 16, DDD = 32, cardiac resynchronization therapy (CRT) = 43] were randomized to either 50/50% fixed tilt (FT) or tuned waveform (3...
December 15, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27960086/integrated-epi-genomic-analyses-identify-subgroup-specific-therapeutic-targets-in-cns-rhabdoid-tumors
#7
Jonathon Torchia, Brian Golbourn, Shengrui Feng, King Ching Ho, Patrick Sin-Chan, Alexandre Vasiljevic, Joseph D Norman, Paul Guilhamon, Livia Garzia, Natalia R Agamez, Mei Lu, Tiffany S Chan, Daniel Picard, Pasqualino de Antonellis, Dong-Anh Khuong-Quang, Aline C Planello, Constanze Zeller, Dalia Barsyte-Lovejoy, Lucie Lafay-Cousin, Louis Letourneau, Mathieu Bourgey, Man Yu, Deena M A Gendoo, Misko Dzamba, Mark Barszczyk, Tiago Medina, Alexandra N Riemenschneider, A Sorana Morrissy, Young-Shin Ra, Vijay Ramaswamy, Marc Remke, Christopher P Dunham, Stephen Yip, Ho-Keung Ng, Jian-Qiang Lu, Vivek Mehta, Steffen Albrecht, Jose Pimentel, Jennifer A Chan, Gino R Somers, Claudia C Faria, Lucia Roque, Maryam Fouladi, Lindsey M Hoffman, Andrew S Moore, Yin Wang, Seung Ah Choi, Jordan R Hansford, Daniel Catchpoole, Diane K Birks, Nicholas K Foreman, Doug Strother, Almos Klekner, Laszló Bognár, Miklós Garami, Péter Hauser, Tibor Hortobágyi, Beverly Wilson, Juliette Hukin, Anne-Sophie Carret, Timothy E Van Meter, Eugene I Hwang, Amar Gajjar, Shih-Hwa Chiou, Hideo Nakamura, Helen Toledano, Iris Fried, Daniel Fults, Takafumi Wataya, Chris Fryer, David D Eisenstat, Katrin Scheinemann, Adam J Fleming, Donna L Johnston, Jean Michaud, Shayna Zelcer, Robert Hammond, Samina Afzal, David A Ramsay, Nongnuch Sirachainan, Suradej Hongeng, Noppadol Larbcharoensub, Richard G Grundy, Rishi R Lulla, Jason R Fangusaro, Harriet Druker, Ute Bartels, Ronald Grant, David Malkin, C Jane McGlade, Theodore Nicolaides, Tarik Tihan, Joanna Phillips, Jacek Majewski, Alexandre Montpetit, Guillaume Bourque, Gary D Bader, Alyssa T Reddy, G Yancey Gillespie, Monika Warmuth-Metz, Stefan Rutkowski, Uri Tabori, Mathieu Lupien, Michael Brudno, Ulrich Schüller, Torsten Pietsch, Alexander R Judkins, Cynthia E Hawkins, Eric Bouffet, Seung-Ki Kim, Peter B Dirks, Michael D Taylor, Anat Erdreich-Epstein, Cheryl H Arrowsmith, Daniel D De Carvalho, James T Rutka, Nada Jabado, Annie Huang
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors...
December 12, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27817184/biomarkers-of-irritable-bowel-syndrome
#8
REVIEW
Jae Hak Kim, Eugenia Lin, Mark Pimentel
Traditionally, irritable bowel syndrome (IBS) has not been regarded as an organic disease, and the pathophysiology of IBS is heterogeneous. Currently, the diagnosis of IBS is based upon the Rome diagnostic criteria. The performance of these criteria is only modest in predicting IBS, and moreover their validation is lacking. Additionally, as functional symptoms are common in the general population, healthy controls or volunteers are difficult to define and there is currently no definition of "normal" in the Rome criteria...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27795384/antimicrobial-susceptibility-of-staphylococcus-isolates-from-the-skin-of-patients-with-diarrhea-predominant-irritable-bowel-syndrome-treated-with-repeat-courses-of-rifaximin
#9
LETTER
Herbert L DuPont, Ray A Wolf, Robert J Israel, Mark Pimentel
No abstract text is available yet for this article.
January 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27682513/a-definitive-blood-test-for-post-infectious-irritable-bowel-syndrome
#10
EDITORIAL
Gillian M Barlow, Ali Rezaie, Eugenia Lin, Mark Pimentel
No abstract text is available yet for this article.
November 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27547364/interspecific-variation-in-the-relationship-between-clutch-size-laying-date-and-intensity-of-urbanization-in-four-species-of-hole-nesting-birds
#11
Marie Vaugoyeau, Frank Adriaensen, Alexandr Artemyev, Jerzy Bańbura, Emilio Barba, Clotilde Biard, Jacques Blondel, Zihad Bouslama, Jean-Charles Bouvier, Jordi Camprodon, Francesco Cecere, Anne Charmantier, Motti Charter, Mariusz Cichoń, Camillo Cusimano, Dorota Czeszczewik, Virginie Demeyrier, Blandine Doligez, Claire Doutrelant, Anna Dubiec, Marcel Eens, Tapio Eeva, Bruno Faivre, Peter N Ferns, Jukka T Forsman, Eduardo García-Del-Rey, Aya Goldshtein, Anne E Goodenough, Andrew G Gosler, Arnaud Grégoire, Lars Gustafsson, Iga Harnist, Ian R Hartley, Philipp Heeb, Shelley A Hinsley, Paul Isenmann, Staffan Jacob, Rimvydas Juškaitis, Erkki Korpimäki, Indrikis Krams, Toni Laaksonen, Marcel M Lambrechts, Bernard Leclercq, Esa Lehikoinen, Olli Loukola, Arne Lundberg, Mark C Mainwaring, Raivo Mänd, Bruno Massa, Tomasz D Mazgajski, Santiago Merino, Cezary Mitrus, Mikko Mönkkönen, Xavier Morin, Ruedi G Nager, Jan-Åke Nilsson, Sven G Nilsson, Ana C Norte, Markku Orell, Philippe Perret, Christopher M Perrins, Carla S Pimentel, Rianne Pinxten, Heinz Richner, Hugo Robles, Seppo Rytkönen, Juan Carlos Senar, Janne T Seppänen, Luis Pascoal da Silva, Tore Slagsvold, Tapio Solonen, Alberto Sorace, Martyn J Stenning, Piotr Tryjanowski, Mikael von Numers, Wieslaw Walankiewicz, Anders Pape Møller
The increase in size of human populations in urban and agricultural areas has resulted in considerable habitat conversion globally. Such anthropogenic areas have specific environmental characteristics, which influence the physiology, life history, and population dynamics of plants and animals. For example, the date of bud burst is advanced in urban compared to nearby natural areas. In some birds, breeding success is determined by synchrony between timing of breeding and peak food abundance. Pertinently, caterpillars are an important food source for the nestlings of many bird species, and their abundance is influenced by environmental factors such as temperature and date of bud burst...
August 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27528177/repeat-treatment-with-rifaximin-is-safe-and-effective-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome
#12
Anthony Lembo, Mark Pimentel, Satish S Rao, Philip Schoenfeld, Brooks Cash, Leonard B Weinstock, Craig Paterson, Enoch Bortey, William P Forbes
BACKGROUND & AIMS: Few treatments have demonstrated efficacy and safety for diarrhea-predominant irritable bowel syndrome (IBS-D). A phase 3, randomized, double-blind, placebo-controlled trial was performed to evaluate the safety and efficacy of repeat treatment with the nonsystemic antibiotic rifaximin. METHODS: The trial included adults with IBS-D, mean abdominal pain and bloating scores of 3 or more, and loose stool, located at 270 centers in the United States and Europe from February 2012 through June 2014...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27489527/update-on-irritable-bowel-syndrome-diagnostics-and-therapeutics
#13
Mark Pimentel
No abstract text is available yet for this article.
July 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27402085/small-intestinal-bacterial-overgrowth-is-associated-with-irritable-bowel-syndrome-and-is-independent-of-proton-pump-inhibitor-usage
#14
Evangelos J Giamarellos-Bourboulis, Emmanouel Pyleris, Charalambos Barbatzas, Aikaterini Pistiki, Mark Pimentel
BACKGROUND: Current knowledge suggests that small intestinal overgrowth participates in the pathogenesis of irritable bowel syndrome. It is questionable if this association is modulated by intake of proton pump inhibitors (PPIs). METHODS: In a prospective study, quantitative cultures of duodenal aspirates were performed for aerobic species in 897 consecutive patients undergoing upper GI tract endoscopy. SIBO was defined as equal to or more than 10(3) cfu/ml. The effect of PPI intake on the relationship between SIBO and IBS was the primary endpoint...
July 11, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27380731/intestinal-methane-production-is-associated-with-decreased-weight-loss-following-bariatric-surgery
#15
Ruchi Mathur, Manpreet S Mundi, Kathleen S Chua, Paul A Lorentz, Gillian M Barlow, Eugenia Lin, Miguel Burch, Adrienne Youdim, Mark Pimentel
To determine whether methane and hydrogen on breath test affects weight loss after bariatric surgery, 156 subjects (pre-surgery BMI ≥33) were recruited ≥4 months after surgery. Pre- and post-surgery weights and BMIs were recorded. Post-surgery methane and hydrogen levels were determined. % total weight loss and % change in BMI were prorated to six months after surgery. M+/H+ subjects (N=13) exhibited lower prorated % change in BMI vs. all other subjects (N=144) (p=0.13), and significantly lower prorated % total weight loss (p=0...
July 2, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27378276/recombinant-human-n-acetylgalactosamine-6-sulfate-sulfatase-galns-produced-in-the-methylotrophic-yeast-pichia-pastoris
#16
Alexander Rodríguez-López, Carlos J Alméciga-Díaz, Jhonnathan Sánchez, Jefferson Moreno, Laura Beltran, Dennis Díaz, Andrea Pardo, Aura María Ramírez, Angela J Espejo-Mojica, Luisa Pimentel, Luis A Barrera
Mucopolysaccharidosis IV A (MPS IV A, Morquio A disease) is a lysosomal storage disease (LSD) produced by mutations on N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Recently an enzyme replacement therapy (ERT) for this disease was approved using a recombinant enzyme produced in CHO cells. Previously, we reported the production of an active GALNS enzyme in Escherichia coli that showed similar stability properties to that of a recombinant mammalian enzyme though it was not taken-up by culture cells. In this study, we showed the production of the human recombinant GALNS in the methylotrophic yeast Pichia pastoris GS115 (prGALNS)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27347377/lovastatin-lactone-may-improve-irritable-bowel-syndrome-with-constipation-ibs-c-by-inhibiting-enzymes-in-the-archaeal-methanogenesis-pathway
#17
Steven M Muskal, Joe Sliman, John Kokai-Kun, Mark Pimentel, Vince Wacher, Klaus Gottlieb
UNLABELLED: Methane produced by the methanoarchaeon Methanobrevibacter smithii ( M. smithii) has been linked to constipation, irritable bowel syndrome with constipation (IBS-C), and obesity. Lovastatin, which demonstrates a cholesterol-lowering effect by the inhibition of HMG-CoA reductase, may also have an anti-methanogenesis effect through direct inhibition of enzymes in the archaeal methanogenesis pathway. We conducted protein-ligand docking experiments to evaluate this possibility...
2016: F1000Research
https://www.readbyqxmd.com/read/27261204/a-predictive-model-to-estimate-cost-savings-of-a-novel-diagnostic-blood-panel-for-diagnosis-of-diarrhea-predominant-irritable-bowel-syndrome
#18
Mark Pimentel, Chris Purdy, Raf Magar, Ali Rezaie
PURPOSE: A high incidence of irritable bowel syndrome (IBS) is associated with significant medical costs. Diarrhea-predominant IBS (IBS-D) is diagnosed on the basis of clinical presentation and diagnostic test results and procedures that exclude other conditions. This study was conducted to estimate the potential cost savings of a novel IBS diagnostic blood panel that tests for the presence of antibodies to cytolethal distending toxin B and anti-vinculin associated with IBS-D. METHODS: A cost-minimization (CM) decision tree model was used to compare the costs of a novel IBS diagnostic blood panel pathway versus an exclusionary diagnostic pathway (ie, standard of care)...
July 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26902227/breath-testing-for-small-intestinal-bacterial-overgrowth-should-we-bother
#19
Mark Pimentel
The hydrogen breath test is based on following breath hydrogen levels after the administration of a carbohydrate (most commonly lactulose) to a patient with suspected small intestinal bacterial overgrowth. The test is based on the interaction between the administered carbohydrate and the intestinal bacteria. The resulting fermentation produces hydrogen. A positive breath test is based on a breath hydrogen rise prior to the expected arrival time in the highly microbial cecum. Despite renewed enthusiasm for breath testing in recent years due to associations with conditions such as irritable bowel syndrome, breath testing poses many challenges...
March 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26833719/metabolic-effects-of-eradicating-breath-methane-using-antibiotics-in-prediabetic-subjects-with-obesity
#20
Ruchi Mathur, Kathleen S Chua, Mindy Mamelak, Walter Morales, Gillian M Barlow, Rita Thomas, Darko Stefanovski, Stacy Weitsman, Zachary Marsh, Richard N Bergman, Mark Pimentel
OBJECTIVE: Methanogens colonizing the human gut produce methane and influence host metabolism. This study examined metabolic parameters in methane-producing subjects before and after antibiotic treatment. METHODS: Eleven prediabetic methane-positive subjects (9F, 2M) with obesity (BMI 35.17 ± 7.71 kg/m(2) ) aged 47 ± 9 years were recruited. Subjects underwent breath testing, symptom questionnaire, oral glucose tolerance test (OGTT), lipid profile, and stool Methanobrevibacter smithii levels, gastric transit, and energy utilization analyses...
March 2016: Obesity
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