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Autoimmune Haemolytic Anemia

Deepak Jain, Harpreet Singh, Gaganpreet Singh, Promil Jain
Varicella is a common infectious exanthematous disease of children. Infection manifests as polymorphic maculopapulovesicular along with low grade fever, malaise and headache. Adults are less likely to be infected with varicella infection but once infected suffer disproportionately from serious complications like pneumonia, encephalitis, hepatitis and thrombocytopenia. Varicella hepatitis is generally a self-limiting disease with only a temporary subclinical rise in hepatic enzymes and are usually encountered however autoimmune hepatitis (AIH) which is an autoimmune disorder of unknown etiology affecting the liver is a very rare association of Varicella infection ...
December 2016: Mædica
B Ramos, G Gastal, R K Rovere
BACKGROUND: Melanoma is one of the fastest growing neoplasms worldwide. Treatment of metastatic disease has swiftly shifted in the last decade from generally ineffective chemotherapy regimens to highly effective targeted treatments or immunotherapy, with a range of side effects that differ completely from those of previous treatments for this disease. CASE: We present a case of a 71-year-old man with diagnosis metastatic melanoma. This patient was treated with anti-CTLA-4 antibody ipilimumab...
December 0: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
P Solves, N Carpio, C Carretero, J I Lorenzo, J Sanz, I Gómez, F López-Chuliá, M J Arilla, A I Regadera, P Montesinos, G F Sanz, M Á Sanz
Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014...
March 2017: Bone Marrow Transplantation
Salony Mittal, Preeti Agarwal, Anupam Wakhlu, Ashutosh Kumar, Raj Mehrotra, Saumya Mittal
INTRODUCTION: Haematological alterations such as anaemia, neutropenia and thrombocytopenia are frequent in Systemic Lupus Erythematosus (SLE). Ferritin being an acute phase reactant can be falsely elevated in lupus cases. AIM: To evaluate the haematological alterations and to re-categorise the types of anemia by soluble transferrin receptor levels in diagnosed cases of SLE. MATERIALS AND METHODS: A sample of 30 newly diagnosed ANA positive SLE patients was taken...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Enrique J deAndrés-Galiana, Juan L Fernández-Martínez, Oscar Luaces, Juan J Del Coz, Leticia Huergo-Zapico, Andrea Acebes-Huerta, Segundo González, Ana P González-Rodríguez
INTRODUCTION: Chronic Lymphocytic Leukemia (CLL) is a disease with highly heterogeneous clinical course. A key goal is the prediction of patients with high risk of disease progression, which could benefit from an earlier or more intense treatment. In this work we introduce a simple methodology based on machine learning methods to help physicians in their decision making in different problems related to CLL. MATERIAL AND METHODS: Clinical data belongs to a retrospective study of a cohort of 265 Caucasians who were diagnosed with CLL between 1997 and 2007 in Hospital Cabueñes (Asturias, Spain)...
April 2016: Journal of Biomedical Informatics
Zahra Nikousefat, Moosa Javdani, Mohammad Hashemnia, Abbas Haratyan, Ali Jalili
INTRODUCTION: Autoimmune haemolytic anemia (AIHA) is a complex process characterized by an immune reaction against red blood cell self-antigens. The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper was written to alert technologists and pathologists to the presence of cold agglutinins and its effect on laboratory tests. CASE PRESENTATION: A 72-year-old female presented to the Shafa laboratory for hematology profile evaluation...
October 2015: Iranian Red Crescent Medical Journal
Marielle Igala, Daniela Nsame, Jennie Dorothée Guelongo Okouango Ova, Siham Cherkaoui, Bouchra Oukkach, Asmae Quessar
Sickle cell anemia results from a single amino acid substitution in the gene encoding the β-globin subunit. Polymerization of deoxygenated sickle hemoglobin leads to decreased deformability of red blood cells. Hashimoto's thyroiditis is a common thyroid disease now recognized as an auto-immune thyroid disorder, it is usually thought to be haemolytic autoimmune anemia. We report the case of a 32 years old women admitted for chest pain and haemolysis anemia in which Hashimoto's thyroiditis and sickle cell anemia were found...
2015: Pan African Medical Journal
Dhwanee Thakkar, Nita Radhakrishnan, P K Pruthi, Anupam Sachdeva
BACKGROUND: Association of autoimmune haemolytic anaemia has been seldom reported with Kawasaki disease. CASE CHARACTERISTICS: A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly. OBSERVATIONS: Positive Direct Coombs test and coronary artery aneurysm on echocardiography. He was managed with steroids along with intravenous immunoglobulins and aspirin. OUTCOME: Early identification of the condition helped in the management...
March 8, 2015: Indian Pediatrics
Paul R J Ames, Darren Aw, Mervin G Rainey
Campath is being employed for the treatment of autoimmune haemolytic anemia (AIHA) whether or not associated to B cell chronic lymphoid leukaemia (CLL). CD5 negative CLL is relatively uncommon and runs an indolent course. We report a CD5 negative CLL patient who developed AIHA associated with cytomegalovirus infection reactivation whilst on treatment with Campath for progressive disease.
September 2014: Indian Journal of Hematology & Blood Transfusion
A Bollotte, T Vial, P Bricca, C Bernard, C Broussolle, P Sève
PURPOSE: Drug-induced immune haemolytic anemia occurs in one case per million and can be fatal. Our aim was to describe the main characteristics and the type of drug involved. METHODS: Cases were retrospectively identified using spontaneous notifications collected by our pharmacovigilance centre and the results of immuno-hematological investigations performed by the laboratory of French blood establishment of Lyon between 2000 and 2012. Inclusion criteria were: an immune (positive direct antiglobulin test), hemolytic, anemia (haemoglobin <100 g/L), with at least a plausible causal relationship with drug exposure according to the French method of imputability or the presence of drug-dependent antibodies, and exclusion of other causes of hemolysis...
December 2014: La Revue de Médecine Interne
Valery Alexandrovich Chereshnev, Polina Vladimirovna Kosareva, Evgeny Ivanovich Samodelkin, Ludmila Vladimirovna Sivakova
UNLABELLED: 2-butoxyethanol (C6H14O2) is widely used in many industrial reagents; according to the in vitro data it was established that 2-butoxyethanol metabolites are strong haemolytic poisons. Ghanayem B.I., Sullivan Ch.A. (1993) investigated in vitro the effect of BE on the red blood cells of 10 species of mammals, including humans. In this study, the authors established the species specificity with regard to the development of hemolytic anemia under the effect of butoxyethanol. In the context of the available data, creation of experimental model based on the introduction of animal butoxyethanol is taking place...
January 2014: Hellenic Journal of Nuclear Medicine
Connie Heiligers-Duckers, Philo T Werner, Marlea E P van Drunen
Reticulocytes are immature erythrocytes; the number of reticulocytes in the peripheral blood reflects erythropoietic activity. Two cases are described to illustrate the use of the reticulocyte count in the diagnostic workup of anaemia. The first patient was a 62-year-old woman presenting with fatigue. Laboratory evaluation showed severe macrocytic anaemia, thrombocytopaenia and the presence of schistocytes. A low reticulocyte count suggested decreased erythropoiesis underlying the anaemia; this led to the diagnosis of vitamin B12 deficiency...
2013: Nederlands Tijdschrift Voor Geneeskunde
Juxian Tong, Wei Kou, Qi Chen, Duan Xiao
Both autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria are common hemolytic diseases. The former causes hemolysis because of immune disorder, and the latter is an acquired clonal hematologic disorder of stem cells. The two entities are often separate diseases, but can also occur concomitantly or secondary to each other. paroxysmal nocturnal haemoglobinuria-like defect-like defect is a special type of autoimmune haemolytic anaemia and should be distinguished from typical paroxysmal nocturnal haemoglobinuria-like defect...
December 2013: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Henrik Birgens, Henrik Frederiksen, Hans C Hasselbalch, Inge H Rasmussen, Ove J Nielsen, Lars Kjeldsen, Herdis Larsen, Torben Mourits-Andersen, Torben Plesner, Dorthe Rønnov-Jessen, Hanne Vestergaard, Tobias W Klausen, Claudia Schöllkopf
The impact of first-line treatment with the anti-CD 20 chimeric monoclonal antibody rituximab in patients with warm-antibody reactive autoimmune haemolytic anaemia (WAIHA) is unknown. We report the first randomized study of 64 patients with newly diagnosed WAIHA who received prednisolone and rituximab combined (N = 32) or prednisolone monotherapy (N = 32). After 12 months, a satisfactory response was observed in 75% of the patients treated with rituximab and prednisolone but in a significantly smaller proportion (36%) of those given prednisolone alone (P = 0·003)...
November 2013: British Journal of Haematology
S Sideris, A Loizidou, A Georgala, F Lebrun, T Gil, Pr Awada, Pr Piccart, F Cardoso
A 61-year-old female, followed-up for a metastatic breast cancer, was admitted in our institution with conjunctival icterus, asthenia and abdominal crampoid pain. The patient was included in a clinical trial comparing the efficiency of capecitabine monotherapy versus capecitabine conjugated with a new biological agent in a randomised and double blind trial. The patient was in the capecitabine alone arm. Biological tests performed upon admission suggested the diagnosis of haemolytic anaemia. Moreover, the direct Coombs test result was twice positive indicating autoimmune haemolytic anaemia...
March 2013: Acta Clinica Belgica
A Agapidou, E Vlachaki, T Theodoridis, M Economou, V Perifanis
Recent advances in the management of hemoglobinopathies offer an improved potential for safe pregnancy with favourable outcome in patients with β-thalassemia major. Autoimmune diseases that are common in women at reproductive age might be fulminant and hardly manageable in pregnant women with thalassemia. Thus immunosuppressant drugs like cyclosporine A could be necessary in order to maintain good maternal and foetal health. We present a case report of a 35-year-old woman with β-thalassemia major, splenectomy, autoimmune hemolytic anemia and insulin treated diabetes mellitus who was treated with cyclosporine A during her pregnancy, and delivered a healthy male infant...
January 2013: Hippokratia
Nidhi Aggarwal, Anand Kumar Rai, Yizhak Kupfer, Sidney Tessler
Glycosylated haemoglobin (HbA1c) is a measurement commonly performed in patients with diabetes. Factors causing a change in the life span of the red blood cell (RBC) can affect the measurement of HbA1c. Thus haemolysis is an important factor that may affect the HbA1c level determination. Haemolysis has been shown to cause a falsely low HbA1c. A 62-year-old man with a history of autoimmune haemolytic anaemia was admitted for severe haemolytic anaemia and an Hb of 2.9 g/dL. HbA1c tested during hospitalisation was unrecordable due to the extremely low Hb...
2013: BMJ Case Reports
Su W Maung, Maeve Leahy, Hilary M O'Leary, Irfan Khan, Mary R Cahill, Oonagh Gilligan, Philip Murphy, Suzanne McPherson, Fred Jackson, Mary Ryan, Brian Hennessy, Johnny McHugh, Matthew Goodyer, Larry Bacon, Peter O'Gorman, Aisling Nee, Michael O'Dwyer, Helen Enright, Jean Saunders, Denis O'Keeffe
This retrospective analysis assessed the response, safety and duration of response to standard dose rituximab 375 mg/m(2) weekly for four weeks as therapy for patients with primary or secondary warm autoimmune haemolytic anaemia (WAIHA), who had failed initial treatment. Thirty-four patients received rituximab for WAIHA in seven centres in the Republic of Ireland. The overall response rate was 70·6% (24/34) with 26·5% (9/34) achieving a complete response (CR). The time to response was 1 month post-initiation of rituximab in 87·5% (21/24) and 3 months in 12·5% (3/24) of patients...
October 2013: British Journal of Haematology
A Wang, J R Smith, K E Creevy
OBJECTIVE: To compare short-term outcome and frequency of adverse events for dogs with idiopathic immune-mediated haemolytic anaemia treated with glucocorticoids and mycophenolate mofetil vs alternate immunosuppressive protocols. METHODS: A retrospective study of medical case records of dogs with immune-mediated haemolytic anaemia was conducted. Data collected included signalment, clinicopathological data, medications administered, duration of hospitalization, short-term survival and adverse events...
August 2013: Journal of Small Animal Practice
Susanta Kumar Das, Amritava Ghosh, Niloy Banerjee, Sudarshan Khaskil, Sabya Sachi Mukherjee
Chronic cold agglutinin disease is a subgroup of auto-immune haemolytic anaemia. Primary cold agglutinin disease has traditionally been defined by the absence of any underlying or associated disease. It usually affects elderly. The term cold refers to the fact that the auto-antibody involved reacts with red cells poorly or not at all at 37 degrees C, whereas it reacts strongly at lower temperature. Here a case of severe pallor, jaundice and red colour urine in winter season for last 10 years diagnosed as a case of primary cold agglutinin disease is reported...
October 2012: Journal of the Indian Medical Association
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