keyword
https://read.qxmd.com/read/38423573/iga-plasma-cell-myeloma-presenting-as-cold-agglutinin-induced-haemolytic-transfusion-reaction
#1
JOURNAL ARTICLE
Maryam Mehdipour Dalivand, Navitha Woddor, Addisalem Makuria, Anita Aggarwal, Victor Eduardo Nava
Cold agglutinins produced in the setting of B cell neoplasms, such as lymphoplasmacytic lymphoma and plasma cell myeloma, can mediate autoimmune haemolytic anemia. Transfusion of these patients can exacerbate cold agglutinin-mediated haemolysis. Moreover, the workup for these reactions represents a diagnostic challenge due in part to false negative direct antiglobulin tests (DATs). Here, we report an anaemic patient who after a red blood cell (RBC) transfusion performed without blood warming, experienced a DAT-negative haemolytic transfusion reaction, and was later diagnosed with IgA-multiple myeloma, which showed an uncommon granular pattern by CD138 immunohistochemistry...
February 28, 2024: BMJ Case Reports
https://read.qxmd.com/read/37942375/autoimmune-hemolytic-anemia-secondary-to-covid-19-vaccine-a-case-report
#2
Mitul H Chaudhary, Anil Kumar Yennam, Nagavenakata Lova Surya Vamshi Avinash Bojanki, Alyssa Nicole G Dela Cruz, Nirali K Chaudhary, Hitesh Kinha, Yoshita Rao Annepu
Autoimmune hemolytic anemia (AIHA) is an acquired hemolysis caused by one's immune system targeting red blood cell surface antigens, resulting in a shortening of the normal red-cell lifespan of 120 days. In this case report, we present an unusual case of a middle-aged woman with no known autoimmune diseases. After ruling out all other possible etiologies, she was later diagnosed with AIHA about two months after receiving her first dose of the Oxford-AstraZeneca COVID-19 vaccine (COVISHIELD). We discuss the possible underlying cause, the COVID-19 vaccine, for the precipitation of AIHA...
October 2023: Curēus
https://read.qxmd.com/read/37933523/immune-checkpoint-inhibitor-associated-hemophagocytic-lymphohistiocytosis-in-a-patient-with-chronic-lymphocytic-leukemia
#3
JOURNAL ARTICLE
Syed B Ali, Bryone Kuss, Chris Karapetis, Tiffany Hughes, Anthony Smith
Haemophagocytic lymphohistiocytosis (HLH) is a rare complication of immune checkpoint inhibitor therapy. A 55-year-old male with stable chronic lymphocytic leukemia presented with fevers and symptomatic anaemia after nine cycles of nivolumab for metastatic melanoma. Investigations were consistent with autoimmune haemolytic anemia and corticosteroids were initiated. Thrombocytopenia and elevated liver enzymes without evidence of chronic lymphocytic leukaemia transformation was present. Ferritin was elevated, and thus HLH was considered and subsequently confirmed on a bone marrow biopsy...
December 2023: Immunotherapy
https://read.qxmd.com/read/37689387/detection-of-red-cell-alloantibody-prior-to-overflow-phenomenon-in-a-case-of-warm-aiha-secondary-to-chronic-lymphocytic-leukemia-and-myasthenia-gravis-a-case-report
#4
JOURNAL ARTICLE
Davood Bava, Vasanth Asirvatham, Saptarshi Mandal, Amit Kumar Rohilla, Siddharth Mittal
INTRODUCTION: Defects in the lymphoid system have been linked to immune dysregulation, which might explain why lymphoid neoplasms and immunological disorders tend to occur concurrently. Chronic Lymphocytic Leukemia (CLL), characterized by the accumulation of dysfunctional lymphocytes, is associated with autoimmune cytopenias such as autoimmune haemolytic anemia (AIHA). Detection of underlying alloantibody in warm AIHA, is challenging for any transfusion medicine specialist. This report highlights the significance of overflow phenonmenon in detection of alloantibody in a case of warm AIHA secondary to CLL and myasthenia gravis...
September 7, 2023: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/37507272/immunohematological-evaluation-of-red-cell-alloimmunization-and-statistical-assessment-of-various-adsorption-techniques-in-warm-autoimmune-hemolytic-anemia
#5
JOURNAL ARTICLE
Sudipta Sekhar Das, Sourav Mukherjee, Sourav Chowdhury
Adsorption techniques are widely applied to detect underlying masked alloantibodies in warm autoimmune hemolytic anemia (WAIHA). We established various adsorption techniques with an aim to detect alloimmunization in WAIHA This study conducted over a period of nine years included 298 patients of WAIHA. Complete immunohematological evaluation was performed on these 298 samples following departmental protocols. Clinical and laboratory details of patients were obtained from patient files. Various adsorption methods were performed and statistically evaluated in the study...
July 26, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/37373803/a-peculiar-cll-case-with-complex-chromosome-6-rearrangements-and-refinement-of-all-breakpoints-at-the-gene-level-by-genomic-array-a-case-report
#6
Michele Cennamo, Davide Sirocchi, Carolina Giudici, Marzia Giagnacovo, Guido Petracco, Daniela Ferrario, Simona Garganigo, Angela Papa, Emanuela Veniani, Alessandro Squizzato, Lucia Del Vecchio, Carlo Patriarca, Michelarcangelo Partenope, Piergiorgio Modena
INTRODUCTION: Chronic lymphocytic leukemia (CLL), the most common leukemia in Western countries, is a mature B-cell chronic lymphoproliferative disorder characterized by the accumulation of neoplastic CD5+ B lymphocytes, functionally incompetent and usually monoclonal in origin, in bone marrow, lymph nodes and blood. Diagnosis occurs predominantly in elderly patients, with a median age reported between 67 and 72 years. CLL has a heterogeneous clinical course, which can vary from indolent to, less frequently, aggressive forms...
June 17, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37073214/uncovering-the-unusual-a-case-of-mixed-connective-tissue-disease-with-rare-presentation-atypical-complications-and-therapeutic-dilemmas
#7
Rajashree S Khot, Adarsh Patil, Bharatsing D Rathod, Madan Patidar, Prashant P Joshi
Mixed connective tissue disease (MCTD) is an overlap syndrome characterized by features of systemic lupus erythematosus, scleroderma, and polymyositis, along with the presence of the U1RNP antibody. A 46-year-old female patient presented with severe anemia, cough, and breathlessness, and was diagnosed with cold agglutinin disease, a type of autoimmune hemolytic anemia (AIHA). Autoimmune workup revealed MCTD by positive antinuclear and U1RNP antibodies. She had bilateral miliary mottling on X-ray and a tree-in-bud appearance on high-resolution computed tomography of the thorax, which were suggestive of pulmonary tuberculosis...
March 2023: Curēus
https://read.qxmd.com/read/36970161/a-rare-cause-of-recurrent-haemolytic-anaemia-carboplatin-and-paclitaxel-induced-autoimmune-haemolytic-anaemia
#8
JOURNAL ARTICLE
Pitchaporn Yingchoncharoen, Jerapas Thongpiya, Shrinkhala Maharjan, Mahmoud Abdelnabi, Samuel Kim, Sakditad Saowapa, Judy Lalmuanpuii
UNLABELLED: Drug-induced immune haemolytic anaemia (DIIHA) is a rare but serious complication affecting approximately 1 in 1,000,000 patients, but its incidence might be underestimated due to misdiagnosis. Several factors should be considered to ensure an accurate diagnosis, including previous medical history, comorbidities, drug history, the temporal relationship between drug exposure and symptom onset, haemolytic features, and comorbidities in suspected cases. The authors report a case of DIIHA caused by combination chemotherapy with carboplatin and paclitaxel complicated with haeme pigment-induced acute kidney injury...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/36934038/clinical-and-immunohematological-characterization-of-autoimmune-hemolytic-anemia-in-children
#9
JOURNAL ARTICLE
Sudipta Sekhar Das, Kaustabh Chaudhuri, Sourav Mukherjee
Autoimmune Hemolytic Anemia (AIHA) in childhood is uncommon and estimated to be three per million annually under 18 years of age. Detailed immunohematological and clinical characterizations are essential for correct diagnosis of the disease and its management. In this study we described AIHA in children with regards to patient demography, underlying etiology, disease classification, antibody characterization, clinical features, degree of in vivo hemolysis and transfusion management. The prospective observational study was conducted over a period of 6 years and included 29 children with newly diagnosed AIHA...
March 15, 2023: Transfusion and Apheresis Science
https://read.qxmd.com/read/36338884/can-sars-cov-2-trigger-new-onset-of-autoimmune-disease-in-adults-a-case-based-review
#10
REVIEW
Balqis Okta Putry, Namira Khairunnisa, Hanny Mutiarayni Balga, Yanto Sandy Tjang, Maria Selvester Thadeus, Frans Santosa, Taufiq Fredrik Pasiak
INTRODUCTION: Although it has been proposed that SARS-CoV-2 can cause autoimmunity by inducing a transient immunodeficiency of both innate and acquired immunity components in which the immune system fails to identify autoantigens adequately, the exact mechanism that causes this disease remains unknown. We aim to systematically review of existing case reports for evidence of new autoimmune diseases in adults caused by SARS-CoV-2 infection. METHODS: PRISMA-P 2020 method was used to search for literature in "PubMed" databases using the string "COVID-19 AND autoimmune disease AND complication"...
November 2022: Heliyon
https://read.qxmd.com/read/36338555/warm-autoimmune-haemolytic-anaemia-complicated-by-simultaneous-arterial-and-venous-thromboses-a-case-report
#11
Ela Ćurčić, Ozrenka Zlopaša, Sara Šundalić, Mia Rora, Radovan Radonić, Ana Vujaklija Brajković
The novelty described in this case report is the simultaneous development of arterial and venous thrombosis in a previously healthy Caucasian 37-year-old male with newly diagnosed warm autoimmune haemolytic anaemia (WA-AIHA). Clinical presentation included sensorimotor dysphasia, right arm paresis, abdominal pain, and swelling of the left leg. Computed tomography angiography showed partial occlusion of the left middle cerebral artery and multiple infarcts of the kidneys and spleen, while Doppler ultrasound revealed thrombosis of the left popliteal vein...
2022: Pan African Medical Journal
https://read.qxmd.com/read/36334945/autoimmune-haemolytic-anaemia
#12
REVIEW
María Argüello Marina, Montserrat López Rubio, Lucía Castilla García
Autoimmune haemolytic anaemias (AIHA) are acquired haematological disorders caused by increased peripheral erythrocyte destruction mediated by autoantibodies against erythrocyte antigens. They classified according to aetiology into primary and secondary, and according to the type of antibody and reaction temperature into AIHA due to warm antibodies (w-AIHA) and AIHA due to cold antibodies (c-AIHA). The mainstay of management in w-AIHA remains glucocorticoid therapy, and the early addition of rituximab has shown good results in recent studies...
January 5, 2023: Medicina Clínica
https://read.qxmd.com/read/36126922/-autoimmune-haemolytic-anemias
#13
JOURNAL ARTICLE
Sabine Ehrlich, Christian Wichmann, Karsten Spiekermann
Autoimmune haemolytic anemia (AIHA) is defined as the immune-mediated destruction of red blood cells. In most cases, antibodies that target surface antigens on erythrocytes lead to their premature degradation in the spleen or, less commonly, in the liver. The term includes a heterogenous group of diseases, which differ largely in pathophysiology and treatment. The two most common entities are warm AIHA and cold AIHA. Diagnostic testing involves the analysis of haemolytic markers like lactate dehydrogenase, haptoglobin and unconjugated bilirubin as well as a hemoglobin and reticulocytes...
September 2022: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/35773127/influence-of-immunohematological-markers-on-severity-of-in-vivo-hemolysis-in-human-warm-autoimmune-haemolytic-anemia
#14
JOURNAL ARTICLE
Sudipta Sekhar Das, Sourav Mukherjee
Autoantibody production in autoimmune haemolytic anemia (AIHA) is the result of the loss of self-immunological tolerance of the host. Here we investigated the various immunohematological markers that may influence the severity of in vivo hemolysis in warm AIHA (WAIHA). Complete direct antiglobulin test (DAT) evaluation and immunohematological characterization were performed in 247 patients of WAIHA following departmental protocols. Clinical and laboratory details of patients were obtained from patient file...
December 2022: Transfusion and Apheresis Science
https://read.qxmd.com/read/35537944/management-of-atypical-uremic-hemolytic-syndrome-in-pregnant-patient
#15
E Simón Polo, J Hernández Laforet, B Carretero de la Encarnación, J A Monsalve Naharro
Atypical uremic haemolytic syndrome is a variant of thrombotic micro-andiopathy characterized by non-autoimmune hemolytic anemia, thrombocytopenia and acute renal failure as a result of excessive activation of the complement. Up to 60% of patients have mutations in the genes that encode the complement system. A disensing factor is required for its manifestation, including gestation. It is an entity with a high morbidity, which can decrease drastically if an early diagnosis is made and appropriate treatment is initiated...
April 2022: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/35485209/cold-agglutinin-mediated-autoimmune-haemolytic-anaemia-associated-with-covid-19-infection-a-case-report
#16
C Y Chang, H H Chin, P W Chin, M Zaid
No abstract text is available yet for this article.
June 2022: Hong Kong Medical Journal
https://read.qxmd.com/read/35440330/severe-autoimmune-hemolytic-anemia-complicating-treatment-naive-chronic-hepatitis-c-infection-a-case-report
#17
Mahadev Meena, Durga Shankar Meena, Deepak Kumar, Sonu Pandit
BACKGROUND: Haematological manifestations in Hepatitis C virus (HCV) infection has been uncommon since the advent of direct-acting antiviral drugs (DAAs). However, primary HCV disease can cause significant haematological disease in the form of various autoimmune cytopenias. CASE PRESENTATION: We herein discuss a 68-years-old female with chronic HCV infection for the last 15 years (not on the treatment), presented with complaints of progressive fatigue, exertional dyspnea, and increased abdominal distention over the previous 20 days...
April 18, 2022: Cardiovascular & Hematological Disorders Drug Targets
https://read.qxmd.com/read/35413226/targeted-next-generation-sequencing-revealed-a-novel-homozygous-mutation-in-the-lrba-gene-causes-severe-haemolysis-associated-with-inborn-errors-of-immunity-in-an-indian-family
#18
JOURNAL ARTICLE
Prabhakar Kedar, Rashmi Dongerdiye, Shanmukhaiah Chandrakala, Umair Ahmed Bargir, Manisha Madkaikar
OBJECTIVES: LPS-responsive beige-like anchor protein (LRBA) deficiency abolishes LRBA protein expression due to biallelic mutations in the LRBA gene that lead to autoimmune manifestations, inflammatory bowel disease, hypogammaglobulinemia in early stages, and variable clinical manifestations. MATERIALS AND METHODS: Mutational analysis of the LRBA gene was performed in Indian patients using targeted Next Generation Sequencing (t-NGS) and confirmed by Sanger sequencing using specific primers of exons 53...
December 2022: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/35307304/impact-of-baseline-fluorescent-antinuclear-antibody-positivity-on-the-clinical-outcome-of-patients-with-primary-autoimmune-hemolytic-anemia
#19
JOURNAL ARTICLE
Aseem Rangnekar, Suchitra Shenoy M, Chakrapani Mahabala, Prashantha Balanthimogru
INTRODUCTION: Autoimmune haemolytic anaemia (AIHA) is an autoimmune disorder that can present in primary or secondary forms. The literature looking at impact of baseline fluorescent antinuclear antibody (FANA) positivity on outcomes of AIHA patients is infrequent. OBJECTIVE: To study the impact of baseline FANA positivity in patients with primary AIHA. METHOD: A prospective cohort study involving 29 consecutive primary AIHA patients presenting to the Haematology department from 2013 to 2015 was analysed...
2023: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/34744345/immunohematological-and-clinical-characterization-of-complement-and-non-complement-associated-warm-autoimmune-haemolytic-anemia-and-risk-factors-predicting-their-occurrences
#20
JOURNAL ARTICLE
Sudipta Sekhar Das, Anupam Chakrapani, Soumya Bhattacharya, Rathindra Nath Biswas, Mahammad Safi
Antigen - antibody complexes on heavily coated red cells in Warm autoimmune haemolytic anemia (WAIHA) often activates the complement pathway and red cells bound C3 complement component are encountered in complement associated WAIHA (CWAIHA). Patients belonging to CWAIHA and non-complement associated WAIHA (NCWAIHA) may demographically, clinically and immunohematologically behave differently therefore we planned to study the clinical and immunohematological characteristics of CWAIHA and NCWAIHA with emphasis to various potential factors associated with CWAIHA...
October 2021: Indian Journal of Hematology & Blood Transfusion
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