keyword
MENU ▼
Read by QxMD icon Read
search

Viral myocarditis

keyword
https://www.readbyqxmd.com/read/28634541/campylobacter-jejuni-myocarditis-a-journey-from-the-gut-to-the-heart
#1
M Toba Obafemi, Homeyra Douglas
OBJECTIVES: Campylobacter jejuni is an unusual cause of myocarditis and could easily be missed. METHODS: We describe a case of a 25 year old man, who presented with 3 day history of vomiting and diarrhoea, followed by chest pain and significant high sensitive troponin rise. RESULTS: The patient's profuse diarrhoea was accompanied by raised inflammatory markers, electrocardiogram changes and evidence of cardiomyopathy on transthoracic echocardiogram...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28630939/retrospective-surveillance-of-wastewater-to-examine-seasonal-dynamics-of-enterovirus-infections
#2
Nichole E Brinkman, G Shay Fout, Scott P Keely
Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis. The disease burden of enteroviruses in the United States is difficult to assess because most infections are not recorded. Since infected individuals shed enterovirus in feces and urine, surveillance of municipal wastewater can reveal the diversity of enteroviruses circulating in human populations. Therefore, monthly municipal wastewater samples were collected for 1 year and enteroviruses were quantified by reverse transcriptase quantitative PCR and identified by next-generation, high-throughput sequencing...
May 2017: MSphere
https://www.readbyqxmd.com/read/28627657/shrna%C3%A2-mediated-np-knockdown-inhibits-the-apoptosis-of-cardiomyocytes-induced-by-h1n1pdm2009-influenza-virus
#3
Kun Yu, Yi Ren, Xiwen Zhang, Taiping Qiao, Zhiguo Liu, Jianhua Shi, Yingnan Wang
Acute influenza-associated myocarditis varies in clinical severity ranging between asymptomatic and fulminant varieties. The most severe cases can result in impaired cardiac function‑associated mortality; however, the mechanism underlying the development of viral myocarditis has yet to be fully elucidated. The present study investigated the apoptosis induced in H9C2 cardiomyocytes by infection with the H1N1pdm2009 virus. The H9C2 cells were transfected with nucleoprotein (NP)‑specific short hairpin (sh) RNA, and viral replication was re‑evaluated in H9C2 cells infected with the H1N1pdm2009 virus, as was the apoptosis induced by the virus...
June 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28622497/feline-panleukopenia-virus-is-not-associated-with-myocarditis-or-endomyocardial-restrictive-cardiomyopathy-in-cats
#4
Laura McEndaffer, Alex Molesan, Hollis Erb, Kathleen Kelly
Canine parvovirus-2 (CPV-2) is nearly indistinguishable from feline panleukopenia virus (FPV) and is a well-known cause of viral myocarditis in young puppies; however, it is not known whether either FPV or CPV-2 naturally infects feline cardiomyocytes and causes myocarditis. Endomyocarditis (EMC) and left ventricular endomyocardial fibrosis (LVEF), clinically known as "endomyocardial restrictive cardiomyopathy," are important feline heart diseases suspected to have an infectious etiology. A continuum is suggested with EMC representing the acute reaction to an unknown infectious agent and LVEF the chronic manifestation of repair...
July 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28603559/three-immune-mediated-disease-models-induced-by-theiler-s-virus-multiple-sclerosis-seizures-and-myocarditis
#5
Ikuo Tsunoda, Fumitaka Sato, Seiichi Omura, Mitsugu Fujita, Namie Sakiyama, Ah-Mee Park
Theiler's murine encephalomyelitis virus (TMEV) infection has been used as a viral model for multiple sclerosis (MS), as TMEV can induce chronic inflammatory demyelinating lesions with viral persistence in the spinal cord of SJL/J mice. In contrast, when C57BL/6 mice are infected with TMEV, the mice can clear the virus from the central nervous system (CNS), without viral persistence or demyelination, but develop seizures and hippocampal sclerosis, which has been used as a viral model for seizures/epilepsy. In the two TMEV-induced CNS disease models, not only viral infection, but also immune responses contribute to the pathogenesis...
November 2016: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/28593659/il-17-induced-expression-of-monocyte-chemoattractant-protein-1-in-cardiac-myocytes-requires-nf-%C3%AE%C2%BAb-through-the-phosphorylation-of-p65
#6
Yan Shen, Xin Xie, Zhuolun Li, Yan Huang, Li Ma, Xinhe Shen, Yanyue Liu, Yuxia Zhao
IL-17 plays a key role in a variety of autoimmune diseases. Monocyte chemoattractant protein-1 (MCP-1) is involved in the infiltration of mononuclear cells of myocardium in viral myocarditis (VMC). However, the relationship between IL-17 and MCP-1 in myocardial injury remains unclear. In this study, the expression of MCP-1 mRNA and protein in cardiac myocytes were detected with qRT-PCR and ELISA respectively. It was found that IL-17A induced MCP-1 expression in a dose and time dependent manner in cardiac myocytes, which could be blocked by IL-17A and IL-17RA neutralizing antibodies...
June 7, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28588491/therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review
#7
REVIEW
Jialiang Gao, Guang Chen, Haoqiang He, Chao Liu, Xingjiang Xiong, Jun Li, Jie Wang
Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28576783/survival-and-left-ventricular-function-changes-in-fulminant-versus-non-fulminant-acute-myocarditis
#8
Enrico Ammirati, Manlio Cipriani, Marzia Lilliu, Paola Sormani, Marisa Varrenti, Claudia Raineri, Duccio Petrella, Andrea Garascia, Patrizia Pedrotti, Alberto Roghi, Edgardo Bonacina, Antonella Moreo, Maurizio Bottiroli, Maria P Gagliardone, Michele G Mondino, Stefano Ghio, Rossana Totaro, Fabio M Turazza, Claudio F Russo, Fabrizio Oliva, Paolo G Camici, Maria Frigerio
Background -Previous reports have suggested that despite their dramatic presentation, patients with fulminant myocarditis (FM) might have better outcome than those with acute non-fulminant myocarditis (NFM). In this retrospective study, we report outcome and changes in left ventricular ejection fraction (LVEF) in a large cohort of patients with FM compared with NFM. Methods -The study population consists of 187 consecutive patients admitted between May 2001 and November 2016 with a diagnosis of acute myocarditis (onset of symptoms <1 month) of whom 55 required inotropes and/or mechanical circulatory support (FM) whilst the remaining 132 patients were hemodynamically stable (NFM)...
June 2, 2017: Circulation
https://www.readbyqxmd.com/read/28560385/the-pi3k-akt-mtor-pathway-is-involved-in-cvb3-induced-autophagy-of-hela-cells
#9
Huan Chang, Xin Li, Qian Cai, Chunyun Li, Lang Tian, Jia Chen, Xiaowei Xing, Yu Gan, Wen Ouyang, Zuocheng Yang
Recent studies have found that viral myocarditis (VMC) associated with coxsackievirus B3 (CVB3) causes autophagy activation after infection, but the specific mechanism is not clear. The present study demonstrated that the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway participates in CVB3‑induced autophagy. We found that the light chain 3 (LC3)‑Ⅱ/LC3‑I ratio was increased and p62 and p‑mTOR were altered at different times during CVB3 infection...
May 31, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28556177/outcome-predictor-in-dilated-cardiomyopathy-or-myocarditis
#10
Friedhelm Kuethe, Marcus Franz, Christian Jung, Christiane Porrmann, Franziska Reinbothe, Peter Schlattmann, Renate Egerer, Gerhard Mall
BACKGROUND: The objective of the present study was to identify parameters of prognostic relevance in patients presenting with chronic left ventricular dysfunction who underwent endomyocardial biopsy. METHODS: 351 consecutive patients (age 47.7±12.6 years, 281 male) with a chronic left ventricular dysfunction were enrolled. Endomyocardial biopsies were analysed by histopathology according to Dallas criteria and immunohistological WHO criteria. Virus genome was detected by polymerase chain reaction...
May 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28550395/a-critical-role-for-il-21-receptor-signaling-in-the-coxsackievirus-b3-induced-myocarditis
#11
Fan Yang, Xiao-Mou Wei, Wen-Wu Liang, Wen-Hong Mo, Bao-Ping Tan, Hong Wang
To determine whether IL-21 receptor signaling plays a significant role in promoting Tfh cell-mediated cardiac injury in viral myocarditis (VMC), we compared IL-21R-deficient mice for some parameters of VMC. Balb/c and IL-21R(-/-) mice were infected with CVB3. Frequencies of splenic Tfh cells were determined by flow cytometric analysis, and productions of anti-adenine nucleotide translocator (ANT) autoantibodies were detected by enzyme-linked immunosorbent assay. To determine the effects of IL-21R signal on the proliferation of B cells, lymphocytes from spleens of the IL-21R(-/-) and Balb/c mice infected by CVB3 were tagged with carboxyfluorescein succinimidyl ester (CFSE) and then were stimulated with lipopolysaccharides plus IL-21 or anti-IL-21 neutralizing antibody for 3 days...
May 26, 2017: Inflammation
https://www.readbyqxmd.com/read/28540218/non-st-elevation-myocardial-infarction-and-post-stenting-ventricular-septal-defect-in-the-setting-of-viral-myocarditis
#12
Lilia M Sierra-Galan, Angel L Alberto-Delgado, Ana-Camila Flores-Ventura, Eugenio A Ruesga-Zamora, Raquel Mendoza-Aguilar, Victor A Ferrari
No abstract text is available yet for this article.
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28539455/functional-consequences-of-rna-5-terminal-deletions-on-coxsackievirus-b3-rna-replication-and-ribonucleoprotein-complex-formation
#13
Nicolas Lévêque, Magali Garcia, Alexis Bouin, Joseph H C Nguyen, Genevieve P Tran, Laurent Andreoletti, Bert L Semler
Group B coxsackieviruses are responsible for chronic cardiac infections. However, the molecular mechanisms by which the virus can persist in the human heart long after the signs of acute myocarditis have abated are still not completely understood. Recently, coxsackievirus B3 strains with 5' terminal deletions in genomic RNAs were isolated from a patient suffering from idiopathic dilated cardiomyopathy, suggesting that such mutant viruses may be the forms responsible for persistent infection. These deletions lacked portions of 5' stem-loop I, which is an RNA secondary structure required for viral RNA replication...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28531186/parvovirus-b19-induced-vascular-damage-in-the-heart-is-associated-with-elevated-circulating-endothelial-microparticles
#14
Katrin Bachelier, Susanne Biehl, Viktoria Schwarz, Ingrid Kindermann, Reinhard Kandolf, Martina Sauter, Christian Ukena, Ali Yilmaz, Karen Sliwa, Claus-Thomas Bock, Karin Klingel, Michael Böhm
BACKGROUND: Diagnosis of viral myocarditis is difficult by clinical criteria but facilitated by detection of inflammation and viral genomes in endomyocardial biopsies. Parvovirus B19 (B19V) targets endothelial cells where viral nucleic acid is exclusively detected in the heart. Microparticles (MPs) are released after cell damage or activation of specific cells. We aimed to investigate whether circulating endothelial MPs (EMPs) in human and experimental models of myocarditis are associated with B19V myocarditis...
2017: PloS One
https://www.readbyqxmd.com/read/28506553/inhibition-of-12-15-lo-ameliorates-cvb3-induced-myocarditis-by-activating-nrf2
#15
Feng Ai, Jiayong Zheng, Yanwei Zhang, Taibing Fan
Cardiac 12/15-lipoxygenase (12/15-LO) was reported to be markedly up-regulated and involved in the development of heart failure. Nuclear factor E2-related factor 2 (Nrf2) plays anti-inflammatory and anti-oxidation roles in response to oxidative stress. However, the role of 12/15-LO in viral myocarditis (VMC) and its underlying molecular mechanism have not yet been elucidated. Here, we demonstrated that 12/15-LO was up-regulated and Nrf2 was down-regulated in coxsackievirus B3 (CVB3)-infected mice and cardiac myocytes...
June 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28499238/inhibition-of-inos-protects-cardiomyocytes-against-coxsackievirus-b3-induced-cell-injury-by-suppressing-autophagy
#16
Li Qi, Qi Xin, Jia Wenjun
BACKGROUND: Coxsackievirus B3 (CVB3), a member of the picornavirus family, is one of the major causative enteroviruses of viral myocarditis. The aim of the current study was to investigate the role and underlying mechanism of iNOS and autophagy in CVB3 infected cardiomyocytes. METHODS: Myocardial cell H9c2 were randomly divided into four groups: control group, CVB3 group, CVB3+L-NAME group and the CVB3+iNOS siRNA group. Cell proliferation was detected by MTT method and cell apoptosis was determined by flow cytometric...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28453502/identification-of-key-genes-affecting-results-of-hyperthermia-in-osteosarcoma-based-on-integrative-chip-seq-targetscan-analysis
#17
Yuxia Shi, Fan Yang, Shuqing Wei, Gang Xu
BACKGROUND The purpose of this study was to research the effects of hyperthermia on osteosarcoma (OS) by integrating the Chromatin Immunoprecipitation with the generation sequencing (ChIP-Seq) and TargetScan analysis of heat shock transcription factor 1 (HSF1). MATERIAL AND METHODS The HSF1 ChIP-seq dataset of GSE60984 was downloaded from the Gene Expressed Omnibus (GEO) database. The HSF1-binding sites were screened by MACS2 in OS cells after 10 and 20 min of hyperthermia, and they were annotated using the ChIPseeker package...
April 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28451703/-inflammatory-cardiomyopathy-and-myocarditis
#18
B Maisch, A D Ristic, S Pankuweit
We describe diagnosis, differential diagnosis, multimodality imaging and medical and invasive diagnostic treatment in patients with inflammatory cardiomyopathy and myocarditis under etiological considerations in reference to a landmark position paper of the Working Group Myocardial and Pericardial Diseases of the European Society of Cardiology together with recent developments in diagnosis and treatment. Diagnosis of the symptomatic patient is the assessment of etiology of inflammatory cardiomyopathy, followed by the clinical presentation, course, treatment option and prognosis...
April 27, 2017: Herz
https://www.readbyqxmd.com/read/28435073/evaluation-of-a-rapid-detection-for-coxsackievirus-b3-using-one-step-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp
#19
A Monazah, M Zeinoddini, A R Saeeidinia
Coxsackievirus B3 (CVB3) is a member of the genus Enterovirus within the family Picornaviridae and is an important pathogen of viral myocarditis, which accounts for more than 50% viral myocarditis cases. VP1 is major capsid protein that this region has a low homology in both amino acid and nucleotide sequences among Enteroviruses. Therefore we have chosen this region for designed a set of RT-LAMP primers for CVB3 detection. For this the total RNA was extracted from 24-h post infected-HeLa cells with complete cytopathic effect (CPE), and applied to a one-step reverse transcription loop-mediated isothermal amplification reaction (RT-LAMP) using CVB3-specific primers...
April 21, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28402006/virus-myocarditis-in-a-1-month-old-boy-presenting-as-two-types-of-paroxysmal-supraventricular-tachycardia
#20
Shuhei Fujita, Takeshi Futatani, Tatsuya Kubo, Masae Itamochi, Yusuke Yachi, Hidenori Iwasaki, Ayako Shimao, Shihomi Ina, Hiroyuki Higashiyama, Noboru Igarashi, Kiyoshi Hatasaki
Herein we describe the case of a 1-month-old boy with acute viral myocarditis, who presented with two kinds of paroxysmal supraventricular tachycardia, and who was cured after medical treatment. He was brought to the emergency room with poor feeding due to fever. On the third day of hospitalization, a narrow QRS tachycardia (180-200 beats/min) was detected. Echocardiography showed a high echoic area at the atrial septum around the atrioventricular node. The patient was clinically diagnosed with acute myocarditis...
May 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
keyword
keyword
37757
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"