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Viral myocarditis

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https://www.readbyqxmd.com/read/28933176/-myocarditis-and-inflammatory-cardiomyopathy
#1
Dalibor Mlejnek, Jan Krejčí
Myocarditis is an inflammation of the heart muscle. The most common cause of myocarditis is viral infection in industrialized countries. Myocarditis with left ventricular dysfunction is called inflammatory cardiomyopathy and is the major cause of dilated cardiomyopathy. The clinical picture is very diverse, most often the patient present with signs of heart failure, arrhythmic symptoms and chest pains. Despite significant advances in non-invasive diagnostics, particularly magnetic resonance imaging, endomyocardial biopsy remains the gold standard of myocarditis diagnosis...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28914852/-efficiency-of-immunosuppressive-therapy-in-virus-negative-and-virus-positive-patients-with-morphologically-verified-lymphocytic-myocarditis
#2
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov
AIM: To evaluate the efficiency of immunosuppressive therapy (IST) in virus-negative (V-) and virus-positive (V+) patients with lymphocytic myocarditis (LM). SUBJECTS AND METHODS: 60 patients (45 males) (mean age 46.7±11.8 years) with dilated cardiomyopathy (mean left ventricular (LV) end diastolic size (EDS) 6.7±0.7 cm; ejection fraction (EF) 26.2±9.1%) were examined. The diagnosis of active/borderline LM was verified by right ventricular endomyocardial biopsy in 38 patients, by intraoperative LV biopsy in 10, in the study of explanted hearts from 3 patients and at autopsy in 9...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28912259/nod2-nucleotide-binding-oligomerization-domain-2-is-a-major-pathogenic-mediator-of-coxsackievirus-b3-induced-myocarditis
#3
Carsten Tschöpe, Irene Müller, Yu Xia, Konstantinos Savvatis, Kathleen Pappritz, Sandra Pinkert, Dirk Lassner, Markus M Heimesaat, Frank Spillmann, Kapka Miteva, Stefan Bereswill, Heinz-Peter Schultheiss, Henry Fechner, Burkert Pieske, Uwe Kühl, Sophie Van Linthout
BACKGROUND: The cytoplasmatic pattern recognition receptor, NOD2 (nucleotide-binding oligomerization domain 2), belongs to the innate immune system and is among others responsible for the recognition of single-stranded RNA. With Coxsackievirus B3 (CVB3) being a single-stranded RNA virus, and the recent evidence that the NOD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in the pathogenesis of CVB3-induced myocarditis, we aimed to unravel the role of NOD2 in CVB3-induced myocarditis...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28912184/inflammatory-cardiomyopathic-syndromes
#4
REVIEW
Barry H Trachtenberg, Joshua M Hare
Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast, inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of the heart (or myocarditis) is the proximate cause of myocardial dysfunction, causing injury that can range from a fully recoverable syndrome to one that leads to chronic remodeling and dilated cardiomyopathy. The most common cause of inflammatory cardiomyopathies in developed countries is lymphocytic myocarditis most commonly caused by a viral pathogenesis...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28887702/necroptosis-may-be-a-novel-mechanism-for-cardiomyocyte-death-in-acute-myocarditis
#5
Fei Zhou, Xuejun Jiang, Lin Teng, Jun Yang, Jiawang Ding, Chao He
In this study, we investigated the roles of RIP1/RIP3 mediated cardiomyocyte necroptosis in CVB3-induced acute myocarditis. Serum concentrations of creatinine kinase (CK), CK-MB, and cardiac troponin I were detected using a Hitachi Automatic Biochemical Analyzer in a mouse model of acute VMC. Histological changes in cardiac tissue were observed by light microscope and expression levels of RIP1/RIP3 in the cardiac tissue were detected via Western blot and immunohistochemistry. The data showed that RIP1/RIP3 was highly expressed in cardiomyocytes in the acute VMC mouse model and that the necroptosis pathway specific blocker, Nec-1, dramatically reduced the myocardial damage by downregulating the expression of RIP1/RIP3...
September 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28875521/chronic-myocarditis-with-a-long-clinical-course-report-of-an-autopsy-case-of-probable-autoimmune-myocarditis
#6
Masayuki Shintaku, Koji Uchiyama, Yohei Kobayashi
The patient was a 54-year-old woman, who died of chronic cardiac insufficiency after a clinical course of 2 years and 4 months. She had complained of myalgia, muscle weakness, and blepharoptosis before the onset of cardiac symptoms, but there was no evidence of myasthenia gravis or collagen-vascular diseases. At autopsy, the heart (280 g) showed marked dilatation of the four chambers and thinning of the ventricular walls. Diffuse and intense lymphocytic infiltration and extensive fibrosis were noted, with the latter being accentuated in the subendocardial and subepicardial zones...
September 6, 2017: Pathology International
https://www.readbyqxmd.com/read/28868104/parvovirus-b19-myocarditis-of-fulminant-evolution
#7
Michael Spartalis, Eleni Tzatzaki, Eleftherios Spartalis, Christos Damaskos, Sophie Mavrogeni, Vassilis Voudris
Myocarditis is an inflammation of the myocardium. Clinical presentation ranges from non-specific systematic symptoms to fulminant collapse and sudden death. Sudden death occurs at rates of 8.6-12% and cardiomyopathy at 9%. In active myocarditis, there is inflammatory cellular infiltrate with myocardial necrosis. The disease is distinguished by clinical presentation in fulminant and non-fulminant myocarditis. We present a rare case of a parvovirus B19-induced fulminant viral myocarditis in a young female. The patient presented with acute onset heart failure mimicking a myocardial infarction, followed by non-specific symptoms that had been misdiagnosed as urinary tract infection...
August 2017: Cardiology Research
https://www.readbyqxmd.com/read/28866672/increased-mobilization-of-cd45-cd34-vla-4-cells-in-acute-viral-myocarditis-induced-by-coxsackievirus-b3
#8
Xingcui Gao, Bin Wei, Yan Deng, Yan Lan Huang, Weifeng Wu
OBJECTIVES: Bone marrow-derived cells (BMCs) have recently been identified to play a vital role in repairing damaged myocardium; however, it is not known whether or not mobilization of BMCs is involved in the pathogenesis of acute viral myocarditis (VMC). Thus, we analyzed the expression of CD45+CD34+VLA-4+ cells and vascular cell adhesion protein-1 (VCAM-1) in a murine model of acute VMC. METHODS: Male BALB/c mice were intraperitoneally infected with coxsackievirus B3 to establish acute VMC...
September 2, 2017: Cardiology
https://www.readbyqxmd.com/read/28856411/evaluation-of-contamination-risks-with-coxsackievirus-b4-e2-in-swiss-albino-mice-stools
#9
Leïla Aguech-Oueslati, Hela Jaidane, Famara Sane, Nedia Jrad-Battikh, Sabrine Ben Hamed, Didier Hober, Jawhar Gharbi
Coxsackie B4 (CV-B4), is a major cause of viral myocarditis, dilated cardiomyopathy, and pancreatitis. Like other human enteroviruses, CV-B4 is ubiquitous, excreted in the stool, transmitted by fecal-oral route, and persists in the environment. In the context of studies on CV-B4 infection, it is important to investigate how this virus can be eliminated and to show the possibility of contamination risk with a CV-B4 E2 infected Swiss albino mice. Swiss albino female mice were inoculated with CV-B4 E2 strain and divided in two groups: the first was intraperitoneally (I...
August 30, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28822807/spontaneous-activation-of-a-mavs-dependent-antiviral-signaling-pathway-determines-high-basal-interferon-%C3%AE-expression-in-cardiac-myocytes
#10
Efraín E Rivera-Serrano, Nicole DeAngelis, Barbara Sherry
Viral myocarditis is a leading cause of sudden death in young adults as the limited turnover of cardiac myocytes renders the heart particularly vulnerable to viral damage. Viruses induce an antiviral type I interferon (IFN-α/β) response in essentially all cell types, providing an immediate innate protection. Cardiac myocytes express high basal levels of IFN-β to help pre-arm them against viral infections, however the mechanism underlying this expression remains unclear. Using primary cultures of murine cardiac and skeletal muscle cells, we demonstrate here that the mitochondrial antiviral signaling (MAVS) pathway is spontaneously activated in unstimulated cardiac myocytes but not cardiac fibroblasts or skeletal muscle cells...
October 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28812526/parvovirus-infection-is-associated-with-myocarditis-and-myocardial-fibrosis-in-young-dogs
#11
Jordan Ford, Laura McEndaffer, Randall Renshaw, Alex Molesan, Kathleen Kelly
Perinatal parvoviral infection causes necrotizing myocarditis in puppies, which results in acute high mortality or progressive cardiac injury. While widespread vaccination has dramatically curtailed the epidemic of canine parvoviral myocarditis, we hypothesized that canine parvovirus 2 (CPV-2) myocardial infection is an underrecognized cause of myocarditis, cardiac damage, and/or repair by fibrosis in young dogs. In this retrospective study, DNA was extracted from formalin-fixed, paraffin-embedded tissues from 40 cases and 41 control dogs under 2 years of age from 2007 to 2015...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28797313/intravenous-immunoglobulins-in-children-with-new-onset-dilated-cardiomyopathy
#12
Josephine F Heidendael, Suzanne L Den Boer, Joanne G Wildenbeest, Michiel Dalinghaus, Bart Straver, Dasja Pajkrt
BACKGROUND: Dilated cardiomyopathy is a rare but serious disorder in children. No effective diagnostic or treatment tools are readily available. This study aimed to evaluate the efficacy of intravenous immunoglobulins in children with new onset dilated cardiomyopathy. Methods and results In this retrospective cohort study, 94 children with new onset dilated cardiomyopathy were followed during a median period of 33 months. All patients with secondary dilated cardiomyopathy - for example, genetic, auto-immune or structural defects - had been excluded...
August 11, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28770956/investigation-into-the-correlations-of-expressions-of-cav-3-and-smad3-with-pathogenesis-and-prognosis-of-viral-myocarditis
#13
H-L Jia, J Liu
OBJECTIVE: To investigate the correlations of expressions of Caveolae-3 (Cav-3) and sma and mad homologue (Smad3) with the pathogenesis and prognosis of viral myocarditis (VMC). MATERIALS AND METHODS: VMC animal models were prepared and divided into the control group, the virus group and the Shenmai group. We detected the levels of creatine kinase isoenzyme (CK-MB) in the serum that was associated with the myocardial injuries, investigated the pathological features of VMC in BALB/C mice via hematoxylin-eosin (HE) staining, measured the mRNA expressions of Cav-3 and Smad3 via Real-time polymerase chain reaction (RT-PCR) and determined the protein expressions of Cav-3 and Smad3 through Western blotting method...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745014/the-hidden-burden-of-influenza-a-review-of-the-extra-pulmonary-complications-of-influenza-infection
#14
Subhashini A Sellers, Robert S Hagan, Frederick G Hayden, William A Fischer
Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary complications of influenza infection, using organ-specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs...
September 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28742212/relevant-researches-on-chronic-viral-myocarditis-cvmc-in-children-complicated-with-arrhythmia-and-thyroid-hormone-level
#15
M-Y Fu, Q-W Wang, Y Xue, F Xu, C-L Li, X-J An
OBJECTIVE: To analyze the correlation between chronic viral myocarditis (CVMC) in children, complicated with arrhythmia and thyroid hormone level. PATIENTS AND METHODS: 60 patients with CVMC complicated with arrhythmia were continuously selected (course of disease > 3 months) and they are were diagnosed with arrhythmia by the routine 18-lead electrocardiogram and 24-hour Holter; the average follow-up time is about 2 years, during which the left ventricular end-diastolic diameter (LVEDd), left ventricular ejection fraction (LVEF), the occurrence rate of malignant arrhythmia events, immune state of T cell and thyroid hormone level (FT3, FT4, TSH, TGAb and TPOAb) were compared...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28735322/viral-infection-of-the-heart-pathogenesis-and-diagnosis
#16
Mateusz Kuffner, Agnieszka Pawlak, Maciej Przybylski
Viral infections of the heart cause serious clinical problems, either as infectious myocarditis, which usually is a consequence of acute infection or as idiopathic dilated cardiomyopathy, resulting rather from a chronic infection. This minireview presents an up-to-date view on pathomechanisms of viral infection of the heart tissues, the role of immune system in controlling infectious process at its various stages and current possibilities of recognizing viral infection of the heart with use of both cardiological and virological methods...
January 2, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28712393/-vcam-1-mediated-migration-of-cd34-vla-4-bone-marrow-derived-cells-into-myocardial-tissues-in-mice-with-acute-viral-myocarditis
#17
Xiaochun Zeng, Xingcui Gao, Weifeng Wu, Bin Wei
Objective To analyze the migration and expression of CD34(+)VLA-4(+) cells under the induction of vascular cell adhesion molecule-1 (VCAM-1) in a murine model of acute viral myocarditis (VMC). Methods Frequency of CD34(+)VLA-4(+) cells in the myocardial tissues and peripheral blood were examined by flow cytometry. The mRNA and protein of VCAM-1 in the myocardial tissues were analyzed by real-time quantitative PCR and Western blotting. Results In the acute VMC mice, CD34(+)VLA-4(+) cell population in the myocardial tissues significantly increased at day 3, peaked at day 7, and then decreased, but it was still higher than that in the control group at day 14 and 28...
July 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28695302/argatroban-attenuates-diabetic-cardiomyopathy-in-rats-by-reducing-fibrosis-inflammation-apoptosis-and-protease-activated-receptor-expression
#18
Yogesh Bulani, Shyam Sunder Sharma
PURPOSE: Chronic diabetes is associated with cardiovascular dysfunctions. Diabetic cardiomyopathy (DCM) is one of the serious cardiovascular complications associated with diabetes. Despite significant efforts in understanding the pathophysiology of DCM, management of DCM is not adequate due to its complex pathophysiology. Recently, involvement of protease-activated receptors (PARs) has been postulated in cardiovascular diseases. These receptors are activated by thrombin, trypsin, or other serine proteases...
July 10, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28680336/significant-reduction-of-peripheral-blood-interleukin-35-and-cd4-ebi3-t-cells-which-are-negatively-correlated-with-an-increase-in-the-plasma-il-17-and-ctni-level-in-viral-myocarditis-patients
#19
Han Ouyang, Li Xiang, Jianchang Chen, Weiting Xu, Yang Jiao, Huaying Shen
INTRODUCTION: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4(+)EBI3(+) T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease. MATERIAL AND METHODS: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4(+)EBI3(+) T cells in 40 VMC patients and in 20 healthy individuals...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28667560/cardiac-autoimmunity-myocarditis
#20
William Bracamonte-Baran, Daniela Čiháková
Myocarditis is the inflammation of the muscle tissues of the heart (myocardium). After a pathologic cardiac-specific inflammatory process, it may progress to chronic damage and dilated cardiomyopathy. The latter is characterized by systolic dysfunction, whose clinical correlate is heart failure. Nevertheless, other acute complications may arise as consequence of tissue damage and electrophysiologic disturbances. Different etiologies are involved in triggering myocarditis. In some cases, such as giant cell myocarditis or eosinophilic necrotizing myocarditis, it is an autoimmune process...
2017: Advances in Experimental Medicine and Biology
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