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JOURNAL ARTICLE
Haiwei Cao, Yi Jiang, Qiang Sun, Ruichen Liu, Yanyan Li, Jing Huang
Alternative blood sampling strategy can enhance the application of therapeutic drug monitoring (TDM), then improve precision therapy and medication compliance. In developing nations, alternative sampling strategy that allows self-sampling and room temperature transport is especially important. This study validates the use of dried blood spot (DBS) and dried plasma spot (DPS) sampling along with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for analyzing seven common antiepileptic drugs (AEDs) (phenytoin, lamotrigine, levetiracetam, topiramate, carbamazepine, oxcarbazepine and its active metabolite 10,11-dihydro-10-hydroxy carbamazepine) and evaluates their applicability to clinical practice...
March 7, 2024: Journal of Pharmaceutical and Biomedical Analysis
#22
JOURNAL ARTICLE
Mohammad Amin Moshayedi, Ali Asilian, Fatemeh Mokhtari
BACKGROUND AND AIMS: Adverse cutaneous drug reactions (ACDRs) are common and potentially life-threatening, while also hindering patient compliance to medications. Given the regional differences in patterns and prevalence of ACDRs, it is important to study the epidemiology, as well as the clinical and outcome patterns of patients with ACDRs in Iran. METHODS: This cross-sectional study on ACDRs was conducted among hospitalized patients in a referral university hospital in the city of Isfahan, Iran...
March 2024: Health Science Reports
#23
JOURNAL ARTICLE
Kaiser O'Sahil Sadiq, Yogamba Mysore Shivakumar, Eshwar Kumar Burra, Kamran Shahid, Yonas Teferra Tamene, Shefali Piyush Mody, Tuheen Sankar Nath
BACKGROUND: Although phenytoin's potential benefits in wound healing, pain relief, and infection control across various wound types have been previously reported, its use in wound care remains limited. OBJECTIVE: To conduct a comprehensive review to assess the efficacy of topical phenytoin compared with standard and alternative treatments for different wound types. MATERIALS AND METHODS: The authors last searched Cochrane Library, PubMed, PubMed Central, and MEDLINE in June 2023...
February 2024: Wounds: a Compendium of Clinical Research and Practice
#24
JOURNAL ARTICLE
Jakob Christensen, Helga Zoega, Maarit K Leinonen, Nils Erik Gilhus, Mika Gissler, Jannicke Igland, Yuelian Sun, Torbjörn Tomson, Silje Alvestad, Marte-Helene Bjørk, Julie Werenberg Dreier
BACKGROUND: The short- and long-term consequences of restricted fetal growth cause considerable concern, and how prenatal exposure to different antiseizure medications (ASMs) affects fetal growth remains uncertain. METHODS: This was a population-based cohort study of liveborn singleton children born in Denmark, Finland, Iceland, Norway, and Sweden from 1996 to 2017. Prenatal exposure was defined as maternal filling of prescriptions for ASM during pregnancy registered in national prescription registries and primary outcomes were adjusted odds ratios (aORs) of microcephaly or being born small for gestational age...
March 2024: The Lancet regional health. Europe
#25
JOURNAL ARTICLE
Akhil Sahib, Amrita Gotur
No abstract text is available yet for this article.
2024: Journal of Neurosciences in Rural Practice
#26
JOURNAL ARTICLE
Hugo A Jiménez-Vázquez, J Alberto Guevara-Salazar, Delia Quintana-Zavala
N-Arylenaminones are highly versatile compounds which can be synthesized in relatively simple ways. In this work we explored the synthesis of the four monosubstituted N-(4-R-phenyl)enaminones 3a (R = NO2), 3b (R = F), 3c (R = H), and 3d (R = OMe) with the goal of determining the influence of the substituents' electronic effects on tautomer stability and biological activity. These compounds were analyzed by means of Density Functional Theory calculations (DFT), to evaluate the relative stability of the possible tautomers...
March 12, 2024: Chemistry & Biodiversity
#27
JOURNAL ARTICLE
Yan-Lin Zhao, Yu-Xin You, Yu-Lang Chen, Ying Zhang, Yan Du, Dao-Quan Tang
An innovative molecularly imprinted polymer membrane (MIPM) was prepared with polyvinylidene difluoride (PVDF) as the support, phenytoin (PHT) as the single template, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linking reagent, azobisisobutyronitrile as the initiator, and acetonitrile-dimethylformamide (1 : 1.5, v/v) as the porogen. These materials were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller measurements and X-ray photoelectron spectroscopy...
March 6, 2024: RSC Advances
#28
Nadia M Saleem, Nidheesh Chencheri, Sen Thomas, Gail Alexander, Biju Madathil
We present a case of a three-year-old girl with a rare genetic epilepsy with developmental delay. She was born to a non-consanguineous parentage and required resuscitation soon after delivery via cesarean section. The patient had her first seizure within 36 hours of life, which progressed into refractory epilepsy. She required multiple hospital admissions due to prolonged seizures. Despite being tried on multiple drug combinations over the years, she responded only to phenytoin. Basic imaging and other investigations, including genetic analysis, revealed a fibroblast growth factor 12 (FGF12) mutation...
February 2024: Curēus
#29
JOURNAL ARTICLE
Punam Salaria, N N Subrahmanyeswara Rao, Tejas M Dhameliya, M Amarendar Reddy
UNLABELLED: The most promising anticonvulsant phytocompounds were explored in this work using docking, molecular dynamic (MD) simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area (MM-PBSA) approaches. A total of 70 phytochemicals were screened against α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid (AMPA), N -methyl-d-aspartate (NMDA), voltage-gated sodium ion channels (VGSC), and carbonic anhydrase enzyme II (CA II) receptors, and the docking results were compared to the reference drug phenytoin...
April 2024: 3 Biotech
#30
JOURNAL ARTICLE
Shivani Tyagi, Rakhi Mishra, Avijit Mazumder, Rupa Mazumder, Gurvinder Singh, Pratibha Pandey
The research involves the synthesis of a series of new pyridine analogs 5(i-x) and their evaluation for anti-epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier-Haack reaction principle. AutoDock 4.2 was used for their in silico screening against AMPA (-amino-3-hydroxy-5-methylisoxazole) receptor (PDB ID:3m3f). For in vivo testing, the maximal electroshock seizure (MES) model was used. The physicochemical, pharmacokinetic, drug-like, and drug-score features of all synthesized compounds were assessed using the online Swiss ADME and Protein Plus software...
March 2024: Chemical Biology & Drug Design
#31
JOURNAL ARTICLE
Yirga Legesse Niriayo, Tesfay Gebregziabher, Gebre Teklemariam Demoz, Nigusse Tesfay, Kidu Gidey
BACKGROUND: Although antiseizure medications play a crucial role in the management of epilepsy, their benefit can be compromised due to drug-related problems. Drug therapy problems can lead to poor seizure control, reduced quality of life, and increased morbidity and mortality in patients with epilepsy. However, in our setting, there is limited knowledge about drug therapy problems and the factors that contribute to them. OBJECTIVE: The aim of this study was to investigate the prevalence and contributing factors of drug-therapy problems among patients with epilepsy...
2024: PloS One
#32
JOURNAL ARTICLE
T M Chernykh, D A Malyugin, M V Khachaturov, A A Shefer, V I Zoloedov
RELEVANCE: Insulinoma is the most common hormonally active neuroendocrine tumor (NET) of the pancreas. In recent years, there has been a trend towards an increase in the incidence of NET especially insulinoma. AIM: Summarizing and analyzing current data on various approaches to the treatment of insulinoma. Our review includes a comprehensive assessment of the advantages and disadvantages of currently available insulinoma treatment methods in comparison with past experience, as well as a review of promising methods that are not currently widely used...
February 28, 2024: Problemy E̊ndokrinologii
#33
REVIEW
Anastasiia D Shkodina, Mainak Bardhan, Hitesh Chopra, Onyekachi Emmanuel Anyagwa, Viktoriia A Pinchuk, Kateryna V Hryn, Anzhelina M Kryvchun, Dmytro I Boiko, Vinay Suresh, Amogh Verma, Mykhailo Yu Delva
Multiple sclerosis is a chronic inflammatory disease that affects the central nervous system and can cause various types of pain including ongoing extremity pain, Lhermitte's phenomenon, trigeminal neuralgia, and mixed pain. Neuropathic pain is a major concern for individuals with multiple sclerosis as it is directly linked to myelin damage in the central nervous system and the management of neuropathic pain in multiple sclerosis is challenging as the options available have limited efficacy and can cause unpleasant side effects...
February 29, 2024: CNS Drugs
#34
JOURNAL ARTICLE
Yoav Kan-Tor, Lior Ness, Liran Szlak, Felix Benninger, Sivan Ravid, Michal Chorev, Michal Rosen-Zvi, Yishai Shimoni, Robert S Fisher
Epilepsy is a severe chronic neurological disease affecting 60 million people worldwide. Primary treatment is with anti-seizure medicines (ASMs), but many patients continue to experience seizures. We used retrospective insurance claims data on 280,587 patients with uncontrolled epilepsy (UE), defined as status epilepticus, need for a rescue medicine, or admission or emergency visit for an epilepsy code. We conducted a computational risk ratio analysis between pairs of ASMs using a causal inference method, in order to match 1034 clinical factors and simulate randomization...
March 2024: Epilepsy Research
#35
JOURNAL ARTICLE
Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
February 27, 2024: Epilepsia
#36
JOURNAL ARTICLE
Partow Mirzaee Saffari, Pooria Asili, Sadaf Eshraghi, Ahad Muhammadnejad, Ahmad Reza Dehpour, Ramin Goudarzi, Alireza Partoazar
To examine the effect of topical phosphatidylserine (PS) on wound healing factors and tissue necrosis in in vivo models. Topical PS was applied to evaluate aspects of the wound healing process and growth factors production of vascular endothelial growth factors (VEGF) as well a necrosis reduction in the skin flap of rat models. Moreover, phenytoin (PHT) and cyclosporine A (CsA) were used topically as positive control treatments in wound and necrosis models, respectively. Immunohistochemistry (IHC) VEGF, transforming growth factor-β (TGF-β), fibroblast growth factor (FGF) and histopathology were analysed on the wounds of rats...
April 2024: Clinical and Experimental Pharmacology & Physiology
#37
JOURNAL ARTICLE
Ronald Oboth, Larrey Kasereka Kamabu, Herve M Lekuya, Godfrey S Bbosa, Martha Sajatovic, Elly Katabira, Mark Kaddumukasa, Moses Galukande
INTRODUCTION: Post-traumatic seizures (PTS) are common among patients with depressed skull fractures (DSF). Understanding the burden of post traumatic seizures and the factors associated among adult patients with DSF is important to improve clinical care. OBJECTIVE: To determine the prevalence and factors associated with post-traumatic seizures among adult patients with DSF at Mulago National Referral hospital (MNRH). METHODS: A cross-sectional study was conducted among 333 study participants between March 2021 and February 2022...
February 17, 2024: Epilepsy & Behavior: E&B
#38
JOURNAL ARTICLE
Samuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, Wenlei Ye, R Ryley Parrish, Maegan Soriano, Samrat Thouta, Janette Mezeyova, Matthew Waldbrook, Richard Dean, Thilo Focken, Mohammad-Reza Ghovanloo, Peter C Ruben, Fiona Scott, Charles J Cohen, James Empfield, J P Johnson
Voltage-gated sodium channel (NaV ) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating neuronal action potential firing to reduce excitability in the brain. However, all currently available NaV -targeting antiseizure medications nonselectively inhibit the brain channels NaV 1.1, NaV 1.2, and NaV 1.6, which potentially limits the efficacy and therapeutic safety margins of these drugs. Here, we report on XPC-7724 and XPC-5462, which represent a new class of small molecule NaV -targeting compounds...
February 15, 2024: ACS Chemical Neuroscience
#39
JOURNAL ARTICLE
Brian Moseley, Dimitrios Bourikas, Svetlana Dimova, Sami Elmoufti, Simon Borghs
INTRODUCTION: This article aimed to assess the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with focal-onset seizures on specific concomitant antiseizure medications (ASMs) taken as part of their treatment regimen. METHODS: This was a post hoc analysis of pooled data from double-blind, placebo-controlled trials (N01252/NCT00490035, N01253/NCT00464269, and N01358/NCT01261325) in patients with uncontrolled focal-onset seizures randomized to BRV (50-200 mg/day) or placebo on the most common concomitant ASMs at trial initiation...
February 15, 2024: Advances in Therapy
#40
JOURNAL ARTICLE
Jennifer Marsh, Angela T Logan, Erin P Bilgili, Lyndsey J Bowman, Allyssa R Webb
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Nirmatrelvir/ritonavir is one of few options for outpatient treatment of COVID-19, but its use has been limited in transplant recipients due to significant drug interactions with immunosuppressants...
February 13, 2024: American Journal of Health-system Pharmacy: AJHP
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