keyword
MENU ▼
Read by QxMD icon Read
search

Phenytoine

keyword
https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#1
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29242650/infusion-dose-requirement-of-rocuronium-in-patients-on-phenytoin-therapy-a-prospective-comparative-study
#2
Veena Sheshadri, Arathi Radhakrishnan, Kusuma Halemani, Venkatesh H Keshavan
Background and Aims: Patients with intracranial tumour are usually on anticonvulsants. Patients on phenytoin therapy demonstrate rapid metabolism of nondepolarising muscle relaxants secondary to enzyme induction. Infusion dose requirement of rocuronium in such patients has been sparingly studied. We studied the continuous infusion dose requirement of rocuronium bromide in patients on phenytoin therapy and its correlation with serum levels of phenytoin. Methods: Seventy-five patients scheduled for supratentorial tumour surgery were included in the study...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29232289/phenytoin-associated-hypocoagulability-in-a-septic-patient
#3
Adam Zayac, Komal Akhtar, Ioana Amzuta
No abstract text is available yet for this article.
November 27, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29217084/oral-phenytoin-protects-against-experimental-cyclophosphamide-chemotherapy-induced-hair-loss
#4
A Y Onaolapo, A A Adebayo, O J Onaolapo
In the current study, effects of oral phenytoin on hair growth in cyclophosphamide-treated rats were assessed with the goal of evaluating the ability of phenytoin to suppress chemotherapy-induced hair loss. Thirty-six rats were randomly assigned to six groups (1k6) of six each (n=6). In all groups, anagen was induced in flank skin of rats by depilation. On day 9 (anagen VI), rats were injected once with either distilled water (groups 1-3) or cyclophoshamide (groups 4-6). From day 10, rats in group 1 and 4 received oral vehicle (distilled water), groups 2 and 5 received oral phenytoin (50mg/kg), while groups 3 and 6 also received oral phenytoin (100mg/kg)...
December 4, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29215341/a-rare-complication-of-phenytoin-infusion-in-newborn-purple-glove-syndrome
#5
Dilek Ulubaş Işık, Nihal Demirel, Sara Erol, Sezin Ünal, Ahmet Yağmur Baş
No abstract text is available yet for this article.
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29207763/carbamazepine-induced-thrombocytopenia
#6
Ruhi Kumar, Sridhar Chivukula, Goutham Reddy Katukuri, U K Chandrasekhar, K N Shivashankar
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29199506/inadequate-response-to-imatinib-treatment-in-chronic-myeloid-leukemia-due-to-a-drug-interaction-with-phenytoin
#7
S Osorio, V Escudero-Vilaplana, I Gómez-Centurión, E González-Arias, X García-González, J L Díez
Imatinib mesylate and the newer BCR-ABL tyrosine kinase inhibitors are the standard therapy for chronic myeloid leukemia. Although these are remarkably effective drugs, some mechanisms of resistance have been identified including drug-to-drug interactions. Here we present the case of a chronic myeloid leukemia patient with an inadequate response to imatinib due to concurrent phenytoin administration. Conspicuously low imatinib plasma trough levels were documented. Imatinib dose was increased from 400 to 800 mg with good response...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29199252/-evaluation-of-pharmacotherapy-on-emergency-and-intensive-care-medicine-the-influence-of-intensity-and-duration-of-invasion
#8
Toru Imai
 Critically ill patients who receive high-level invasion show physiological changes different from those under more normal conditions, along with variable therapeutic effects and pharmacokinetics. The concept of systemic inflammatory response syndrome (SIRS) has been introduced to describe the clinical state resulting from invasive actions taken under acute circumstances, resulting in an acute-phase systemic response. In particular, dosages of vancomycin (VCM) and phenytoin (PHT) need to be adjusted by therapeutic drug monitoring (TDM) because of their narrow therapeutic concentration windows...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29196247/early-and-late-post-traumatic-epilepsy-in-the-setting-of-traumatic-brain-injury-a-review-of-anti-epileptic-management
#9
Christopher D Wilson, Josh D Burks, Richard B Rodgers, Robert M Evans, Adewale A Bakare, Sam Safavi-Abbasi
INTRODUCTION: Moderate to severe traumatic brain injury confers increased risk of early and late post-traumatic seizures (PTS). Early PTS are diagnosed when seizures develop within 7 days following injury, whereas initial seizures in late PTS occur later. Traditionally, patients have been treated with phenytoin (PHT) to prevent early PTS, and more recently with levetiracetam (LEV). Various regimens have been tried in patients to prevent late PTS with variable success. In this meta-analysis, we assessed and compared effectiveness of these drugs on early and late PTS prevention...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29193939/-prevalence-of-subclinical-hypothyroidism-in-pediatric-patients-with-drug-resistant-epilepsy
#10
Adriana Lorena Aparicio-Claure, Jesús Darío Rayo-Mares, Elisa Nishimura-Meguro, Julia Rocío Herrera-Márquez, Juan Pablo Muñoz-Montúfar, Juan Carlos Núñez-Enríquez
BACKGROUND: In several studies it has been reported a high prevalence of subclinical hypothyroidism in children with epilepsy secondary to the use of monotherapy with valproic acid, carbamazepine and phenytoin. The aim of this article is to determine the prevalence of subclinical hypothyroidism in children with drug-resistant epilepsy treated at the Pediatric Neurology Service of the Hospital de Pediatría, Centro Médico Nacional Siglo XXI in Mexico City. METHODS: We conducted a descriptive cross-sectional study...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29185625/unusual-warfarin-dose-to-achieve-therapeutic-inr-in-a-4-month-old-child-non-genetics-risk-factors-are-still-a-challenge
#11
Lucas Miyake Okumura, Giovanna Webster Negretto, Clarissa Gutiérrez Carvalho
OBJECTIVE: To report a case of a 4-month old girl that required 0.7 mg/kg/day (5 mg) of warfarin and discuss relevant risk factors for requiring higher doses. CASE DESCRIPTION: In November 2015, a 5 kg female infant (36-week preterm) was admitted to the hospital due to status epilepticus and fever. Diazepam, phenytoin and ceftriaxone were prescribed. Cerebrospinal fluid contained 7 leukocytes, 150 mg/dL proteins, 1 mg/dL glucose and gram positive cocci were observed...
October 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29184346/cutaneous-adverse-drug-reactions-to-lamotrigine-and-human-leukocyte-antigen-typing-in-north-indian-patients-a-case-series
#12
Shivani Srivastava, Bhargavi Ramanujam, Kavish Ihtisham, Manjari Tripathi
Cutaneous adverse drug reaction (cADR) has limited epidemiological data in India. The older antiepileptic drugs, i.e., carbamazepine, phenytoin, valproic acid, phenobarbitone, etc., induce severe cADRs that have a strong associated with human leukocyte antigen (HLA)-related genetic risk factors. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, but this has not been reported in the Indian population. Here, we report case series of three patients with LTG-induced "Stevens-Johnson syndrome (SJS)...
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29175014/influence-of-sedation-on-onset-and-quality-of-euthanasia-in-sheep
#13
Michele Barletta, Erik H Hofmeister, John F Peroni, Merrilee Thoresen, Alexandra M Scharf, Jane E Quandt
The purpose of this study was to determine if dexmedetomidine administered IV prior to euthanasia in sheep affected the speed or quality of euthanasia. Twenty clinically healthy Dorset-cross adult ewes between 1 and 3years of age were enrolled in a randomized blinded experimental trial. The subjects were randomly assigned to receive dexmedetomidine 5μg/kg IV or an equivalent volume of saline. Five minutes later, euthanasia was accomplished with a pentobarbital/phenytoin overdose given IV. The time to apnea, asystole, cessation of audible heartbeat, and absence of corneal reflex were recorded by two blinded investigators...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29171002/pharmacokinetic-pharmacodynamic-analysis-of-adjunctive-perampanel-in-subjects-with-partial-onset-seizures
#14
O Takenaka, J Ferry, K Saeki, A Laurenza
OBJECTIVES: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial-onset seizures (POS) and identify factors explaining between-subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. MATERIALS & METHODS: Population PK analysis was performed using nonlinear mixed-effect modeling with data from phase II/III randomized, double-blind, placebo-controlled studies of adjunctive perampanel in POS...
November 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29170352/55%C3%A2-mini-sim-innovative-bite-sized-simulation-teaching-in-a-busy-children-s-emergency-department
#15
Rachel Sunley, Karen Moloney, Jessica Parker, Christopher Arrowsmith, Kirsty Brown, Alex Wilson
: Emergency Medicine requires a highly skilled workforce who are passionate about delivering excellent patient care. Shift patterns linked with the ever increasing numbers of patients who attend Emergency Departments puts strain on educating the workforce and fostering team togetherness.Our objective in devising and instigating the 'Mini Sim' programme was to embed regular in-situ simulation training to enhance the learning of all staff within our Emergency Department team, building a highly trained workforce to deliver excellent care within the remit of our busy department...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29161629/the-effects-of-felbamate-on-appetitive-and-aversive-instrumental-learning-in-adult-rats
#16
John J Orczyk, Preston E Garraghty
Antiepileptic medications are the frontline treatment for seizure conditions but are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin-, carbamazepine-, and valproate-treated rats. In the present experiment, the effects of felbamate (FBM) have been compared to water-treated controls (controls) using the same instrumental training tasks employed here. Rats treated with FBM displayed a deficit in acquiring a tone-signaled avoidance response, relative to controls, but this was true only if they had no prior appetitive experience...
November 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29135699/phenytoin-induced-excessive-sedation-during-awake-craniotomy-an-unusual-observation
#17
Ankur Khandelwal, Navdeep Sokhal, Niraj Kumar, Shalendra Singh, Suman Sokhal
No abstract text is available yet for this article.
November 10, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29133240/prediction-of-human-cns-pharmacokinetics-using-a-physiologically-based-pharmacokinetic-modeling-approach
#18
Yumi Yamamoto, Pyry A Välitalo, Yin Cheong Wong, Dymphy R Huntjens, Johannes H Proost, An Vermeulen, Walter Krauwinkel, Margot W Beukers, Hannu Kokki, Merja Kokki, Meindert Danhof, Johan G C van Hasselt, Elizabeth C M de Lange
Knowledge of drug concentration-time profiles at the central nervous system (CNS) target-site is critically important for rational development of CNS targeted drugs. Our aim was to translate a recently published comprehensive CNS physiologically-based pharmacokinetic (PBPK) model from rat to human, and to predict drug concentration-time profiles in multiple CNS compartments on available human data of four drugs (acetaminophen, oxycodone, morphine and phenytoin). Values of the system-specific parameters in the rat CNS PBPK model were replaced by corresponding human values...
November 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29131525/modified-dispersive-liquid-phase-microextraction-based-on-sequential-injection-solidified-floating-organic-drop-combined-with-hplc-for-the-determination-of-phenobarbital-and-phenytoin
#19
Arezou Amiri Pebdani, Shayesteh Dadfarnia, Ali Mohammad Haji Shabani, Saeid Khodadoust, Mohammad Sharif Talebianpoor
A modified dispersive liquid phase microextraction based on sequential injection solidified floating organic drop was developed for simultaneous separation/preconcentration of trace amounts of phenobarbital and phenytoin. The important factors affecting on the extraction recovery including pH, the volume of extraction solvent, ionic strength and the number of injections were investigated and optimized by Box-Behnken design and desirability function. Under the optimum experimental conditions, the calibration graph was linear in the concentration range of 1...
November 13, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29130833/changes-in-the-pharmacokinetics-of-phenytoin-in-dextran-sulfate-sodium-induced-ulcerative-colitis-in-mice
#20
Yoshiki Kusunoki, Yurika Kido, Yuichi Naito, Risako Kon, Nanaho Mizukami, Miho Kaneko, Nobuyuki Wakui, Yoshiaki Machida, Nobutomo Ikarashi
We previously demonstrated that the expression levels of drug-metabolizing enzymes, cytochrome P450 (CYP) enzymes, in the liver are significantly decreased in a murine model of ulcerative colitis (UC). In this study, we investigated changes in the pharmacokinetics of phenytoin, a CYP2C substrate drug, in the presence of UC. Colitis was induced by feeding male mice 3.5% dextran sulfate sodium (DSS) dissolved in drinking water for 10 days. The messenger RNA (mRNA) expression of CYP2C29 and CYP2C37 and the protein expression of CYP2C in the liver were evaluated via real-time reverse transcription-polymerase chain reaction and Western blotting, respectively...
January 1, 2017: International Journal of Toxicology
keyword
keyword
37753
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"