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https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#1
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27908799/isolation-of-novel-stilbenoids-from-the-roots-of-cyrtopodium-paniculatum-orchidaceae
#2
Florence Auberon, Opeyemi Joshua Olatunji, Diamondra Raminoson, Christian D Muller, Beatriz Soengas, Frédéric Bonté, Annelise Lobstein
Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50 values of 45...
November 28, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27901263/negative-effects-of-submandibular-botulinum-neurotoxin-a-injections-on-oral-motor-function-in-children-with-drooling-due-to-central-nervous-system-disorders
#3
Karen van Hulst, Carlyn V Kouwenberg, Pieter H Jongerius, Ton Feuth, Franciscus J A van den Hoogen, Alexander C H Geurts, Corrie E Erasmus
AIM: The aims of this study were: (1) to determine the incidence and nature of adverse effects on oral motor function after first injections of botulinum neurotoxin A (BoNT-A) in submandibular glands for excessive drooling in children with central nervous system disorders; and (2) to identify independent predictors of these adverse effects. METHOD: A cohort study involved 209 children (123 males, 86 females, aged 4-27y, median 8y 4mo), who received submandibular BoNT-A injections for drooling...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27900354/dataset-of-botulinum-toxin-a-influence-on-interleukins-under-neuropathy
#4
Magdalena Zychowska, Ewelina Rojewska, Wioletta Makuch, Siro Luvisetto, Flaminia Pavone, Sara Marinelli, Barbara Przewlocka, Joanna Mika
Our data show that botulinum toxin A (BoNT/A) didn't influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and IL-18) decreased and antinociceptive (IL-10 and IL-1RA) factors increased. Additionally, our behavioral analysis shows that chronic minocycline treatment together with a single BoNT/A injection in CCI-exposed rats has beneficial analgesic effects (M...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27898177/a-mechanism-for-sequence-specificity-in-plant-mediated-interactions-between-herbivores
#5
Wei Huang, Christelle A M Robert, Maxime R Hervé, Lingfei Hu, Zoe Bont, Matthias Erb
Herbivore communities are shaped by indirect plant-mediated interactions whose outcomes are strongly dependent on the sequence of herbivore arrival. However, the mechanisms underlying sequence specificity are poorly understood. We examined the mechanisms that govern sequence-specific effects of the interaction between two specialist maize herbivores, the leaf feeder Spodoptera frugiperda and the root feeder Diabrotica virgifera virgifera. In the field, S. frugiperda reduces D. v. virgifera abundance, but only when it arrives on the plant first...
November 29, 2016: New Phytologist
https://www.readbyqxmd.com/read/27888665/bronchiolitis-and-asthma-the-next-step
#6
Louis Bont
No abstract text is available yet for this article.
November 23, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27884737/botulinum-neurotoxin-type-a-alleviates-mechanical-hypersensitivity-associated-with-infraorbital-nerve-constriction-injury-in-rats
#7
Noboru Noma, Kosuke Watanabe, Yuka Sato, Yoshiki Imamura, Yumiko Yamamoto, Reio Ito, Mitsuru Maruno, Kohei Shimizu, Koichi Iwata
We investigated the effect of botulinum neurotoxin type A (BoNT-A) on mechanical allodynia and hyperalgesia associated with infraorbital nerve constriction (ION-CCI) in rats. ION-CCI rats received a subcutaneous BoNT-A injection into the whisker pad area on day 7 postoperatively and underwent pain assessment on days 14 and 21 postoperatively. Rats were assigned to one of four treatment groups (n=5 each): ION-CCI+BoNT-A 20pg (low-dose group), ION-CCI+BoNT-A 200pg (high-dose group), ION-CCI+saline, and Sham. Mechanical allodynia and hyperalgesia were evaluated preoperatively (baseline) and on days 7, 14, and 21 postoperatively...
November 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27880052/functional-impact-of-different-muscle-localization-techniques-for-botulinum-neurotoxin-a-injections-in-clinical-routine-management-of-post-stroke-spasticity
#8
Kirsten E Zeuner, Arne Knutzen, Carina Kühl, Bettina Möller, Helge Hellriegel, Nils G Margraf, Günther Deuschl, Henning Stolze
BACKGROUND: Treatment options for spasticity include intramuscular botulinum neurotoxin A (BoNT-A) injections. Both ultrasound (US) or electromyographic (EMG) guided BoNT-A injections are employed to isolate muscles. To date, most studies have included patients naïve to BoNT-A or following a prolonged wash out phase. OBJECTIVE: To determine the impact of US/EMG guided BoNT-A injections on function in outpatients with spasticity receiving an established re-injection regime...
November 23, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27878594/healthy-brain-ageing-assessed-with-18f-fdg-pet-and-age-dependent-recovery-factors-after-partial-volume-effect-correction
#9
Stijn Bonte, Pieter Vandemaele, Stijn Verleden, Kurt Audenaert, Karel Deblaere, Ingeborg Goethals, Roel Van Holen
No abstract text is available yet for this article.
November 23, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27871449/botulinum-toxin-as-early-intervention-for-spasticity-after-stroke-or-non-progressive-brain-lesion-a-meta-analysis
#10
Raymond L Rosales, Fran Efendy, Ericka Sa Teleg, Mary Md Delos Santos, Mary Ce Rosales, Marc Ostrea, Michelle J Tanglao, Arlene R Ng
Spasticity is a functionally limiting disorder that commonly occurs following stroke or severe brain injury, and may lead to disability and pain. In tandem with neurorehabilitation, botulinum toxin type A (BoNT-A) is the recommended first-line treatment for spasticity and, to date, the majority of trials have reported BoNT-A use in patients >6months after ictus. The present meta-analysis aimed to evaluate the effects of early BoNT-A injection for post-stroke spasticity on improvements in hypertonicity, disability, function and associated pain...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27864751/defining-the-risk-and-associated-morbidity-and-mortality-of-severe-respiratory-syncytial-virus-infection-among-infants-with-chronic-lung-disease
#11
REVIEW
Bosco Paes, Brigitte Fauroux, Josep Figueras-Aloy, Louis Bont, Paul A Checchia, Eric A F Simões, Paolo Manzoni, Xavier Carbonell-Estrany
INTRODUCTION: The REGAL (RSV evidence-a geographical archive of the literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This third publication covers the risk and burden of RSV infection in infants with chronic lung disease (CLD), formerly called bronchopulmonary dysplasia (BPD). METHODS: A systematic review was undertaken of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials...
November 18, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27855719/an-illness-focused-interactive-booklet-to-optimise-management-and-medication-for-childhood-fever-and-infections-in-out-of-hours-primary-care-study-protocol-for-a-cluster-randomised-trial
#12
Eefje G P M de Bont, Geert-Jan Dinant, Gijs Elshout, Gijs van Well, Nick A Francis, Bjorn Winkens, Jochen W L Cals
BACKGROUND: Fever is the most common reason for a child to be taken to a general practitioner (GP), especially during out-of-hours care. It is mostly caused by self-limiting infections. However, antibiotic prescription rates remain high, especially during out-of-hours care. Anxiety and lack of knowledge among parents, and perceived pressure to prescribe antibiotics amongst GPs, are important determinants of excessive antibiotic prescriptions. An illness-focused interactive booklet has the potential to improve this by providing parents with information about fever self-management strategies...
November 17, 2016: Trials
https://www.readbyqxmd.com/read/27855161/an-integrative-approach-to-computational-modelling-of-the-gene-regulatory-network-controlling-clostridium-botulinum-type-a1-toxin-production
#13
Adaoha E C Ihekwaba, Ivan Mura, John Walshaw, Michael W Peck, Gary C Barker
Clostridium botulinum produces botulinum neurotoxins (BoNTs), highly potent substances responsible for botulism. Currently, mathematical models of C. botulinum growth and toxigenesis are largely aimed at risk assessment and do not include explicit genetic information beyond group level but integrate many component processes, such as signalling, membrane permeability and metabolic activity. In this paper we present a scheme for modelling neurotoxin production in C. botulinum Group I type A1, based on the integration of diverse information coming from experimental results available in the literature...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27852950/photoperiod-affects-the-phenotype-of-mitochondrial-complex-i-mutants
#14
Pierre Pétriacq, Linda De Bont, Lucie Genestout, Jingfang Hao, Constance Laureau, Igor Florez-Sarasa, Touami Rzigui, Guillaume Queval, Françoise Gilard, Caroline Mauve, Florence Guérard, Marlène Lamothe-Sibold, Jessica Marion, Chantal Fresneau, Spencer Craig Brown, Antoine Danon, Anja Krieger-Liszkay, Richard Berthomé, Miquel Ribas-Carbo, Guillaume G B Tcherkez, Gabriel Cornic, Bernard Pineau, Bertrand Gakiere, Rosine De Paepe
Plant mutants for genes encoding subunits of mitochondrial Complex I (CI, NADH:ubiquinone oxidoreductase), the first enzyme of the respiratory chain, display various phenotypes depending on growth conditions. Here, we examined the impact of photoperiod, a major environmental factor controlling plant development, on two Arabidopsis thaliana CI mutants: a new insertion mutant interrupted in both ndufs8.1 and ndufs8.2 genes encoding the NDUFS8 subunit, and the previously characterized ndufs4 CI mutant. In long day (LD) condition, both ndufs8...
November 16, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27852706/efficacy-of-two-injection-site-localisation-techniques-for-botulinum-toxin-injections-a-single-blind-crossover-randomised-trial-protocol-among-adults-with-hemiplegia-due-to-stroke
#15
Claire Morel, Isabelle Hauret, Nicolas Andant, Armand Bonnin, Bruno Pereira, Emmanuel Coudeyre
INTRODUCTION: Botulinum toxin injections are an effective treatment for limb spasticity following stroke. Different tracking techniques are used for this purpose: palpation, electrostimulation, electromyography and ultrasound. Yet very few studies have compared these different techniques, and none has successfully proved the superior efficacy of ultrasound-guided injections compared to another tracking method. The primary objective of our study was therefore to compare the efficacy of botulinum toxin injections depending on the tracking technique used: ultrasound versus electrostimulation...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27836031/surveillance-of-cattle-health-in-the-netherlands-monitoring-trends-and-developments-using-routinely-collected-cattle-census-data
#16
I M G A Santman-Berends, H Brouwer-Middelesch, L Van Wuijckhuise, A J G de Bont-Smolenaars, G Van Schaik
Since 2002, a national cattle health surveillance system (CHSS) is in place that consists of several surveillance components. The CHSS combines enhanced passive reporting, diagnostic and post-mortem examinations, random surveys for prevalence estimation of endemic diseases and quarterly data analysis. The aim of the data-analysis component, which is called the Trend Analysis Surveillance Component (TASC), is to monitor trends and developments in cattle health using routine census data. The challenges that were faced during the development of TASC and the merits of this surveillance component are discussed, which might be of help to those who want to develop a monitoring and surveillance system that includes data analysis...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27830106/occurrence-of-dysphagia-following-botulinum-toxin-injection-in-parkinsonism-related-cervical-dystonia-a-retrospective-study
#17
Addie Patterson, Leonardo Almeida, Christopher W Hess, Daniel Martinez-Ramirez, Michael S Okun, Ramon L Rodriguez, Valerie Rundle-Gonzalez, Aparna Wagle Shukla, Irene A Malaty
BACKGROUND: The aim was to compare the occurrence of post-injection dysphagia in parkinsonism-related cervical dystonia (PRCD) versus cervical dystonia (CD) of other etiologies (non-PRCD). A secondary objective was to explore potential clinical differences between PRCD and non-PRCD and their respective responses to botulinum toxin (BoNT). METHODS: A cross-sectional chart review was carried out of patients treated for CD with Onabotulinumtoxin A at the University of Florida...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27825345/reconfiguring-health-workforce-a-case-based-comparative-study-explaining-the-increasingly-diverse-professional-roles-in-europe
#18
Antoinette de Bont, Job van Exel, Silvia Coretti, Zeynep Güldem Ökem, Maarten Janssen, Kristin Lofthus Hope, Tomasz Ludwicki, Britta Zander, Marie Zvonickova, Christine Bond, Iris Wallenburg
BACKGROUND: Over the past decade the healthcare workforce has diversified in several directions with formalised roles for health care assistants, specialised roles for nurses and technicians, advanced roles for physician associates and nurse practitioners and new professions for new services, such as case managers. Hence the composition of health care teams has become increasingly diverse. The exact extent of this diversity is unknown across the different countries of Europe, as are the drivers of this change...
November 8, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27816992/impaired-heart-rate-variability-in-cervical-dystonia-is-associated-to-depression
#19
F Hentschel, D Dressler, M Abele, S Paus
Causes of cardiovascular autonomic dysfunction in cervical dystonia (CD) are poorly understood. Studies examining effects of botulinum neurotoxin (BoNT) therapy on heart rate variability (HRV) yielded contradictory results. There is compelling evidence that depression shifts autonomic balance towards sympathetic predominance. As depression is the most frequent non-motor symptom in CD, we sought to determine if it is associated to dysfunction of cardiovascular autonomic regulation. Standardized interviews, clinical examinations, self-rating forms, autonomic symptom questionnaire, and automated autonomic testing in outpatients with idiopathic CD were used...
November 5, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27814412/an-update-on-neurotoxin-products-and-administration-methods
#20
Julien Lanoue, Joanna Dong, Timothy Do, Gary Goldenberg
Since onabotulinumtoxinA for nonsurgical aesthetic enhancement of glabellar lines was initially reported, the popularity of botulinum neurotoxin (BoNT) products among both clinicians and consumers has rapidly grown, and we have seen several additional BoNT formulations enter the market. As the demand for minimally invasive cosmetic procedures continues to increase, we will see the introduction of additional formulations of BoNT products as well as new delivery devices and administration techniques. In this article, we provide a brief update on current and upcoming BoNT products and also review the literature on novel administration methods based on recently published studies...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
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