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Stereotactic radiation therapy

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https://www.readbyqxmd.com/read/28350950/spine-oncology-metastatic-spine-tumors
#1
David Choi, Mark Bilsky, Michael Fehlings, Charles Fisher, Ziya Gokaslan
Surgery for spinal metastases remains the mainstay treatment for pain, instability, and neurological deterioration due to tumor infiltration of the spine. However, several new therapies are emerging which may improve outcomes further, and in some cases even replace the need for surgery. We now have a better understanding of which factors influence survival and quality of life after surgery, and this underpins the development and application of new treatments, and assessment of outcome.Depending on genetic subtyping of tumors, novel immunotherapies and chemotherapies may be very effective in prolonging quality of life...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28344180/benefit-and-complications-of-frame-based-stereotactic-biopsy-in-old-and-very-old-patients
#2
Johanna Quick-Weller, Julia Tichy, Nazife Dinc, Stephanie Tritt, Sae-Yeon Won, Bedjan Behmanesh, Markus Bruder, Volker Seifert, Lutz Weise, Gerhard Marquardt
OBJECTIVE: Stereotactic biopsy is an everyday procedure implemented in numerous neurosurgical departments. The procedure is performed in order to obtain tumor tissue of unclear diagnosis. Going in hand with low complication rates and high diagnostic yield, stereotactic biopsies can be performed in adults and children likewise for histopathological evaluation of lesions in eloquent localizations. Little is known, however, whether aged patients do benefit from stereotactic biopsy or rather the therapy that is derived from histopathological results...
March 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28343896/assessment-of-hepatic-function-decline-after-stereotactic-body-radiation-therapy-for-primary-liver-cancer
#3
Diego A S Toesca, Evan C Osmundson, Rie von Eyben, Jenny L Shaffer, Albert C Koong, Daniel T Chang
PURPOSE: This study aims to determine how the albumin-bilirubin (ALBI) score compares with the Child-Pugh (CP) score for assessing liver function following stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: In total, 60 patients, 40 with hepatocellular carcinoma (HCC) and 20 with cholangiocarcinoma (CCA), were treated with SBRT. Liver function panels were obtained before and at 1, 3, 6, and 12 months after SBRT. Laboratory values were censored after locoregional recurrence, further liver-directed therapies, or liver transplant...
October 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28342648/the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-target-tracking-system-during-radiation-therapy-based-on-kilovoltage-intrafraction-monitoring-kim
#4
Doan Trang Nguyen, Ricky O'Brien, Jung-Ha Kim, Chen-Yu Huang, Lee Wilton, Peter Greer, Kimberley Legge, Jeremy T Booth, Per Rugaard Poulsen, Jarad Martin, Paul J Keall
PURPOSE: We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. The method was applied to measure and correct for target motion during stereotactic body radiotherapy (SBRT) for prostate cancer. METHODS: Patient: A patient with prostate adenocarcinoma undergoing SBRT with 36.25Gy, delivered in 5 fractions was enrolled in the study...
March 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28341320/gallbladder-toxicity-and-high-dose-ablative-intent-radiation-for-liver-tumors-should-we-constrain-the-dose
#5
Shyam K Tanguturi, Andrzej Niemierko, Jennifer Y Wo, Khanhnhat N Nguyen, Hugh Prichard, Andrew X Zhu, John A Wolfgang, Theodore S Hong
PURPOSE: Little is known about the risk of gallbladder toxicity from hypofractionated (HFXRT) and stereotactic body radiation therapy (SBRT). We report on gallbladder toxicity and attribution to treatment in a prospective series of patients with primary and metastatic liver tumors receiving ablative-intent HFXRT and SBRT with protons. METHODS AND MATERIALS: We evaluated 93 patients with intact gallbladders enrolled in either of 2 trials investigating proton HFXRT and SBRT for primary and metastatic liver tumors from 2009 to 2014...
February 9, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28341317/target-volume-and-artifact-evaluation-of-a-new-data-driven-4d-ct
#6
Rachael Martin, Tinsu Pan
PURPOSE: Four-dimensional computed tomography (4D CT) is often used to define the internal gross target volume (IGTV) for radiation therapy of lung cancer. Traditionally, this technique requires the use of an external motion surrogate; however, a new image, data-driven 4D CT, has become available. This study aims to describe this data-driven 4D CT and compare target contours created with it to those created using standard 4D CT. METHODS AND MATERIALS: Cine CT data of 35 patients undergoing stereotactic body radiation therapy were collected and sorted into phases using standard and data-driven 4D CT...
February 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28341061/vmat-plus-a-few-computer-optimized-non-coplanar-imrt-beams-vmat-tested-for-liver-sbrt
#7
Abdul Wahab M Sharfo, Maarten L P Dirkx, Sebastiaan Breedveld, Alejandra Méndez Romero, Ben J M Heijmen
PURPOSE: To propose a novel treatment approach, designated VMAT+, involving addition of <5 IMRT beams with computer-optimized non-coplanar orientations to VMAT, and evaluate it for liver Stereotactic Body Radiation Therapy (SBRT). VMAT+ is investigated as an alternative for (1) coplanar VMAT and (2) multi-beam non-coplanar treatment. METHODS/MATERIALS: For fifteen patients with liver metastases, VMAT+ plans were compared with (1) dual-arc VMAT and (2) 25-beam, non-coplanar treatment with computer-optimized beam orientations (25-NCP)...
March 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28339109/validation-of-dynamic-treatment-couch-tracking-for-prostate-sbrt
#8
Stefanie Ehrbar, Simon Schmid, Alexander Jöhl, Stephan Klöck, Matthias Guckenberger, Oliver Riesterer, Stephanie Tanadini-Lang
PURPOSE: In stereotactic body radiation therapy (SBRT) of prostatic cancer, a high dose per fraction is applied to the target with steep dose gradients. Intrafractional prostate motion can occur unpredictably during the treatment and lead to target miss. This work investigated the dosimetric benefit of motion compensation with dynamic treatment-couch tracking for prostate SBRT treatments in the presence of prostatic motion. METHODS: Ten SBRT treatment plans for prostate cancer patients with integrated boosts to their index lesion were prepared...
March 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28336480/can-a-commercially-available-epid-dosimetry-system-detect-small-daily-patient-setup-errors-for-cranial-imrt-srs
#9
Emmelyn S Hsieh, Katherine S Hansen, Michael S Kent, Sanjeev Saini, Sonja Dieterich
PURPOSE: The purpose of this study was to determine if the Sun Nuclear PerFRACTION electronic portal imager device dosimetry software would be able to detect setup errors in a clinical setting and would be able to correctly identify the direction in which the setup error was introduced. METHODS AND MATERIALS: A 7-field intensity modulated radiation therapy (IMRT) treatment plan for a centrally located tumor was developed for 1 phantom and 5 canine cadaver heads...
December 24, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28335794/tumor-motion-changes-in-stereotactic-body-radiotherapy-for-liver-tumors-an-evaluation-based-on-four-dimensional-cone-beam-computed-tomography-and-fiducial-markers
#10
Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya, Fujio Araki
BACKGROUND: For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning simulation represents liver tumor motion during SBRT, and estimated inter- and intrafractional tumor motion changes in patients undergoing liver SBRT. METHODS: Ten patients underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided liver SBRT with abdominal compression (AC) and fiducial markers...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28333016/predictors-of-liver-toxicity-following-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#11
Michael Velec, Carol R Haddad, Tim Craig, Lisa Wang, Patricia Lindsay, James Brierley, Anthony Brade, Jolie Ringash, Rebecca Wong, John Kim, Laura A Dawson
PURPOSE: To identify risk factors associated with a decline in liver function after stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma. METHODS AND MATERIALS: Data were analyzed from patients with hepatocellular carcinoma treated on clinical trials of 6-fraction SBRT. Liver toxicity was defined as an increase in Child-Pugh (CP) score ≥2 three months after SBRT. Clinical factors, SBRT details, and liver dose-volume histogram (DVH) parameters were tested for association with toxicity using logistic regression...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28333015/role-of-stereotactic-body-radiation-therapy-before-orthotopic-liver-transplantation-retrospective-evaluation-of-pathologic-response-and-outcomes
#12
Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio
PURPOSE: To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT). METHODS AND MATERIALS: The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT radiographs were compared with pathologic gold standard...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28333013/the-risk-of-radiation-induced-tumors-or-malignant-transformation-after-single-fraction-intracranial-radiosurgery-results-based-on-a-25-year-experience
#13
Bruce E Pollock, Michael J Link, Scott L Stafford, Ian F Parney, Yolanda I Garces, Robert L Foote
PURPOSE: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). METHODS AND MATERIALS: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332992/clinical-implementation-of-a-model-based-in%C3%A2-vivo-dose-verification-system-for-stereotactic-body-radiation-therapy-volumetric-modulated-arc-therapy-treatments-using-the-electronic-portal-imaging-device
#14
Peter M McCowan, Ganiyu Asuni, Eric Van Uytven, Timothy VanBeek, Boyd M C McCurdy, Shaun K Loewen, Naseer Ahmed, Bashir Bashir, James B Butler, Amitava Chowdhury, Arbind Dubey, Ahmet Leylek, Maged Nashed
PURPOSE: To report findings from an in vivo dosimetry program implemented for all stereotactic body radiation therapy patients over a 31-month period and discuss the value and challenges of utilizing in vivo electronic portal imaging device (EPID) dosimetry clinically. METHODS AND MATERIALS: From December 2013 to July 2016, 117 stereotactic body radiation therapy-volumetric modulated arc therapy patients (100 lung, 15 spine, and 2 liver) underwent 602 EPID-based in vivo dose verification events...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28327948/three-or-more-courses-of-stereotactic-radiosurgery-for-patients-with-multiply-recurrent-brain-metastases
#15
Rupesh Kotecha, Nicholas Damico, Jacob A Miller, John H Suh, Erin S Murphy, Chandana A Reddy, Gene H Barnett, Michael A Vogelbaum, Lilyana Angelov, Alireza M Mohammadi, Samuel T Chao
BACKGROUND: Although patients with brain metastasis are treated with primary stereotactic radiosurgery (SRS), the use of salvage therapies and their consequence remains understudied. OBJECTIVE: To study the intracranial recurrence patterns and salvage therapies for patients who underwent multiple SRS courses. METHODS: A retrospective review was performed of 59 patients with brain metastases who underwent ≥3 SRS courses for new lesions. Cox regression analyzed factors predictive for overall survival...
February 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28325266/stage-i-small-cell-lung-cancer-a-new-potential-option-for-stereotactic-ablative-radiation-therapy-a-review-of-literature
#16
REVIEW
Filippo Alongi, Stefano Arcangeli, Berardino De Bari, Niccolò Giaj-Levra, Alba Fiorentino, Rosario Mazzola, Marco Trovò
Small cell lung cancer (SCLC) is relative rare histology in lung cancer patients. The standard treatment, in patients with an intra-thoracic disease, is represented by the use of concurrent chemo-radiotherapy; while patients with early SCLC stage, surgical resection could be recommended. Stereotactic body radiotherapy (SBRT) is a recently introduced technique allowing the delivery of very high radiation doses to limited target volumes and it is considered the standard approach in the treatment of not operable stage I Non Small-Cell Lung Cancer (NSCLC)...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#17
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28317152/-68-ga-psma-pet-for-radiation-treatment-planning-in-prostate-cancer-recurrences-after-surgery-individualized-medicine-or-new-standard-in-salvage-treatment
#18
Gregor Habl, Katharina Sauter, Kilian Schiller, Sabrina Dewes, Tobias Maurer, Matthias Eiber, Stephanie E Combs
BACKGROUND: (68) Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving (68) Ga-PSMA-PET imaging before salvage radiotherapy (RT). METHODS AND MATERIALS: In this study, 100 patients with biochemical failure after RP± prior RT who underwent (68) Ga-PSMA PET/CT or PET/MRI were evaluated undergoing salvage RT in our department...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28315510/policies-for-reirradiation-of-recurrent-high-grade-gliomas-a-survey-among-italian-radiation-oncologists
#19
Carlo Furlan, Stefano Arcangeli, Michele Avanzo, Maria A Mirri, Fernando Munoz, Stefania Giudici, Antonio Perrone, Dante Amelio, Luigi Tomio, Loredana Draghini, Aniko M Deli, Giovanni Pavanato, Francesca M Giuliano, Antonio Pontoriero, Patrizia Ciammella, Pierina Navarria, Alberto Iannalfi, Michela Buglione, Cesare Guida, Silvia Cammelli, Vincenzo Iorio, Massimo Cardinali, Domenico Genovesi, Lucia Barsacchi, Mario Balducci, Rita Bagnoli, Franco Berti, Giampaolo Montesi, Francesco Pasqualetti, Paolo Bonome, Riccardo Santoni, Daniela Doino, Patrizia Schirru, Valentina Pinzi, Valentina Borzillo, Fabio Ferrarese, Marica Ferro, Luigi De Cicco, Marco Krengli, Silvia Scoccianti, Vittorio Donato
PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach...
March 18, 2017: Tumori
https://www.readbyqxmd.com/read/28314970/-is-surgical-treatment-ever-indicated-in-metastatic-renal-cell-carcinoma-and-if-so-based-on-which-scientific-rationale
#20
M Burger
BACKGROUND: Metastasis is a common event in renal cell carcinoma. Surgical resection of metastases may be feasible in two scenarios: aiming at palliation, which may be feasible due to reduced radiosensitivity of renal cell cancer, and aiming at prolonging survival, which may be feasible given the rather good prognosis of some patterns of metastasis. OBJECTIVE: This review intends to reflect on current evidence for surgical resection of metastases in both scenarios...
March 17, 2017: Der Urologe. Ausg. A
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