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Stereotactic radiation therapy

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https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#1
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663405/a-career-path-for-pure-academic-medical-physicists-in-radiation-oncology-should-be-established
#2
Ke Sheng, Todd Pawlicki, Jing Cai
Medical physics research has led to many advanced radiation oncology technologies in the past decades, such as intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and proton therapy. These have fundamentally shaped the current landscape of cancer treatment. It is believed that medical physics research will continue to play an essential role in advancing radiation oncology in the future. However, sustaining a healthy medical physics research workforce is facing substantial challenges, such as limited funding support and lack of protected research time...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29662656/stereotactic-body-radiation-therapy-for-palliative-management-of-pancreatic-adenocarcinoma-in-elderly-and-medically-inoperable-patients
#3
John F Ryan, Lauren M Rosati, Vincent P Groot, Dung T Le, Lei Zheng, Daniel A Laheru, Eun J Shin, Juan Jackson, Joseph Moore, Amol K Narang, Joseph M Herman
Stereotactic body radiation therapy (SBRT) represents a promising treatment option for patients with localized pancreatic ductal adenocarcinoma (PDAC) who cannot tolerate surgical therapy. We retrospectively reviewed the records of patients with localized PDAC treated with SBRT at our institution between 2010 and 2016 to identify patients deemed medically inoperable due to poor performance status, advanced age, and/or comorbid conditions. Overall survival (OS), progression-free survival (PFS), and local progression-free survival (LPFS) were estimated using Kaplan-Meier curves...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662531/cystic-brain-metastases-in-alk-rearranged-non-small-cell-lung-cancer
#4
REVIEW
Guilherme Nader Marta, Renata Rodrigues da Cunha Colombo Bonadio, Renata Eiras Martins, Henrique Bortot Zuppani, Gilberto de Castro
The central nervous system (CNS) is a common site of disease progression in patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearrangement treated with crizotinib. Cystic brain metastases (CBM) have been recently identified as one possible variant of this disease. An illustrative case report is presented along with a literature review performed in order to track relevant papers about CBM in ALK-rearranged NSCLC, including possible pathophysiology, differential diagnosis and treatment options for this condition...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29661254/the-risk-and-predictors-for-severe-radiation-pneumonitis-in-lung-cancer-patients-treated-with-thoracic-reirradiation
#5
Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang, Guang Li
BACKGROUND: Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. METHODS: Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients...
April 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29656869/comparing-treatment-strategies-for-stage-i-small-cell-lung-cancer
#6
Peter Paximadis, Jennifer L Beebe-Dimmer, Julie George, Anne G Schwartz, Antoinette Wozniak, Shirish Gadgeel
INTRODUCTION: The diagnosis of stage I small-cell lung cancer (SCLC) is increasing in incidence with the advent of low-dose screening computed tomography. Surgery is considered the standard of care but there are very few data to guide clinical decision-making. The purpose of this study was to compare outcomes for patients receiving definitive surgery, stereotactic body radiation therapy (SBRT), or external beam radiation therapy (EBRT) for stage I SCLC. PATIENTS AND METHODS: Patients with a primary diagnosis of stage I SCLC were identified in the National Cancer Database...
March 23, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29656632/long-term-survival-in-patients-treated-with-a-robotic-radiosurgical-device-for-liver-metastases
#7
Sebastian Stintzing, Jobst von Einem, Christoph Fueweger, Alfred Haidenberger, Michael Fedorov, Alexander Muavcevic
Purpose: The treatment of liver metastases with local procedures is a fast progressing field. For the most, long-term survival data is missing raising questions with regard to the efficacy of such modalities when compared to surgical resection. Radiosurgery using the CyberKnife device enables the treatment of liver lesions with a single-session approach. Here we present long-term survival data to explore the curative potential of this strategy. Materials and Methods: Patients with oligo-metastatic disease limited to the liver have been treated with single-session or hypo-fractioned radiosurgery in curative intent and prospectively followed until death...
April 16, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29652232/long-term-tumor-control-following-stereotactic-radiosurgery-for-jugular-paraganglioma-using-3d-volumetric-segmentation
#8
Neil S Patel, Matthew L Carlson, Bruce E Pollock, Colin L W Driscoll, Brian A Neff, Robert L Foote, Christine M Lohse, Michael J Link
OBJECTIVE The morbidity of gross-total resection of jugular paraganglioma (JP) is often unacceptable due to the potential for irreversible lower cranial neuropathy. Stereotactic radiosurgery (SRS) has been used at the authors' institution since 1990 for the treatment of JP and other benign intracranial tumors. Conventional means of assessing tumor progression using linear measurements or elliptical approximations are imprecise due to the irregular shape and insinuating growth pattern of JP. The objective of this study was to assess long-term tumor control in these patients by using slice-by-slice 3D volumetric segmentation of serial MRI data...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#9
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29622079/lung-cancer-posttreatment-imaging-radiation-therapy-and-imaging-findings
#10
REVIEW
Marcelo F Benveniste, James Welsh, Chitra Viswanathan, Girish S Shroff, Sonia L Betancourt Cuellar, Brett W Carter, Edith M Marom
In this review, we discuss the different radiation delivery techniques available to treat non-small cell lung cancer, typical radiologic manifestations of conventional radiotherapy, and different patterns of lung injury and temporal evolution of the newer radiotherapy techniques. More sophisticated techniques include intensity-modulated radiotherapy, stereotactic body radiotherapy, proton therapy, and respiration-correlated computed tomography or 4-dimensional computed tomography for radiotherapy planning. Knowledge of the radiation treatment plan and technique, the completion date of radiotherapy, and the temporal evolution of radiation-induced lung injury is important to identify expected manifestations of radiation-induced lung injury and differentiate them from tumor recurrence or infection...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29622046/complete-intracranial-response-to-talimogene-laherparepvec-t-vec-pembrolizumab-and-whole-brain-radiotherapy-in-a-patient-with-melanoma-brain-metastases-refractory-to-dual-checkpoint-inhibition
#11
Zoë Blake, Douglas K Marks, Robyn D Gartrell, Thomas Hart, Patti Horton, Simon K Cheng, Bret Taback, Basil A Horst, Yvonne M Saenger
BACKGROUND: Immunotherapy, in particular checkpoint blockade, has changed the clinical landscape of metastatic melanoma. Nonetheless, the majority of patients will either be primary refractory or progress over follow up. Management of patients progressing on first-line immunotherapy remains challenging. Expanded treatment options with combination immunotherapy has demonstrated efficacy in patients previously unresponsive to single agent or alternative combination therapy. CASE PRESENTATION: We describe the case of a patient with diffusely metastatic melanoma, including brain metastases, who, despite being treated with stereotactic radiosurgery and dual CTLA-4/PD-1 blockade (ipilimumab/nivolumab), developed systemic disease progression and innumerable brain metastases...
April 6, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29619976/ablative-hypofractionated-radiation-therapy-enhances-non-small-cell-lung-cancer-cell-killing-via-preferential-stimulation-of-necroptosis-in-vitro-and-in-vivo
#12
Huan-Huan Wang, Zhi-Qiang Wu, Dong Qian, Nicholas G Zaorsky, Ming-Han Qiu, Jing-Jing Cheng, Chao Jiang, Juan Wang, Xian-Liang Zeng, Chun-Lei Liu, Li-Jun Tian, Guo-Guang Ying, Mao-Bin Meng, Xi-Shan Hao, Zhi-Yong Yuan
PURPOSE: To investigate how necroptosis (ie, programmed necrosis) is involved in killing of non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy (HFRT). METHODS AND MATERIALS: Deoxyribonucleic acid damage, DNA repair, and the death form of NSCLC cells were assessed after radiation therapy. The overexpression and silencing of receptor-interacting protein kinases 3 (RIP3, a key protein involved activation of necroptosis)-stable NSCLC cell lines were successfully constructed...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29619964/stereotactic-ablative-radiation-therapy-versus-surgery-in-early-lung-cancer-a-meta-analysis-of-propensity-score-studies
#13
Hanbo Chen, Joanna M Laba, R Gabriel Boldt, Christopher D Goodman, David A Palma, Suresh Senan, Alexander V Louie
PURPOSE: As no completed randomized trials of surgery versus stereotactic ablative radiation therapy (SABR) in patients with early-stage non-small cell lung cancer are available, numerous propensity score studies have attempted to mimic the setting of clinical trials using nonrandomized data. We performed a meta-analysis of propensity score studies comparing SABR and surgery. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried up to December 2016...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29618107/incidence-and-time-of-onset-of-osseous-pseudoprogression-in-patients-with-metastatic-spine-disease-from-renal-cell-or-prostate-carcinoma-after-treatment-with-stereotactic-body-radiation-therapy
#14
Pejman Jabehdar Maralani, Kathleen Winger, Sean Symons, Matylda Machnowska, Chinthaka Heyn, Ali Helmi, Aimee Chan, Chia-Lin Tseng, Arjun Sahgal
BACKGROUND: Tumor osseous pseudoprogression (PP), defined as an imaging-based transient increase in tumor size following treatment, was recently described in patients with spinal metastases following stereotactic body radiation therapy. Distinguishing PP from true tumor progression is critical. OBJECTIVE: To describe the incidence, time of onset, and time range of PP following stereotactic body radiation therapy in patients treated for spinal metastases from either prostate cancer (PC) or renal cell carcinoma (RCC), and associated predictive factors...
March 29, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29616661/shell-feature-a-new-radiomics-descriptor-for-predicting-distant-failure-after-radiotherapy-in-non-small-cell-lung-cancer-and-cervix-cancer
#15
Hongxia Hao, Zhiguo Zhou, Shulong Li, Genevieve Maquilan, Michael R Folkert, Puneeth Iyengar, Kenneth D Westover, Kevin Albuquerque, Fang Liu, Hak Choy, Robert D Timmerman, Lin Yang, Jing Wang
Distant failure is the main cause for human cancer-related mortalities. To develop a model for predicting distant failure in non-small cell lung cancer (NSCLC) and cervix caner (CC) patients, a shell feature, consisting of outer voxels around the tumor boundary, was constructed using pre-treatment positron emission tomography (PET) images from 48 NSCLC patients received stereotactic body radiation therapy (SBRT) and 52 CC patients underwent external beam radiation therapy and concurrent chemotherapy followed with high-dose-rate intracavitary brachytherapy...
April 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29615363/trends-in-medicare-reimbursement-and-work-relative-value-unit-production-in-radiation-oncology
#16
Charles C Vu, Thomas B Lanni, Sirisha R Nandalur
PURPOSE: Medicare payments to individual physicians are released annually by the CMS. The purpose of this study is to analyze trends in Medicare reimbursement and work relative value unit (wRVU) production to radiation oncologists. MATERIALS AND METHODS: The Medicare Physician Supplier and Other Provider Public Use File and the CMS Physician Fee Schedule Relative Value Files (to calculate wRVUs) for the calendar years 2012 to 2015 were used in this analysis. Medicare reimbursement was aggregated for each calendar year...
March 31, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29614361/effectiveness-of-pet-ct-as-a-guide-for-palliative-radiation-therapy-for-spinal-metastases
#17
Neil D Almeida, Crystal Adams, Gregory L Davis, Justin Buro, Nadim Nasr, Don McRae, George Cernica, Anthony Caputy, Robert Hong, Jonathan Sherman
BACKGROUND: As back pain is the presenting symptoms in 95% of patients with epidural spinal metastases, appropriately identifying and treating the most symptomatic levels can provide significant palliation. OBJECTIVE: The purpose of this study is to analyze the ability of PET-CT to identify spinal metastases with high metabolic activity and guide radiotherapy. We sought to correlate improvement in back pain with reduction in SUV uptake following treatment. METHODS: We conducted a retrospective review of 72 patients with bony spinal metastases treated with stereotactic ablative radiation therapy at a single center between 2002 and 2014...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29611866/gamma-knife-radiosurgery-for-arteriovenous-malformations-general-principles-and-preliminary-results-in-a-swiss-cohort
#18
Matthieu Raboud, Constantin Tuleasca, Philippe Maeder, Luis Schiappacasse, Maud Marguet, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Arteriovenous malformations (AVMs) are a type of vascular malformation characterised by an abnormal connection between arteries and veins, bypassing the capillary system. This absence of capillaries generates an elevated pressure (hyperdebit), in both the AVM and the venous drainage, increasing the risk of rupture. Management modalities are: observation, microsurgical clipping, endovascular treatment and radiosurgery. The former can be used alone or in the frame of a multidisciplinary approach...
April 3, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29608701/stereotactic-radiosurgery-for-intracranial-ependymomas-an-international-multicenter-study
#19
Hideyuki Kano, Yan-Hua Su, Hsiu-Mei Wu, Gabriela Simonova, Roman Liscak, Or Cohen-Inbar, Jason P Sheehan, Antonio Meola, Mayur Sharma, Gene H Barnett, David Mathieu, Lucas T Vasas, Anthony M Kaufmann, Rachel C Jacobs, L Dade Lunsford
BACKGROUND: Stereotactic radiosurgery (SRS) is a potentially important option for intracranial ependymoma patients. OBJECTIVE: To analyze the outcomes of intracranial ependymoma patients who underwent SRS as a part of multimodality management. METHODS: Seven centers participating in the International Gamma Knife Research Foundation identified 89 intracranial ependymoma patients who underwent SRS (113 tumors). The median patient age was 16...
March 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#20
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
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