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Amitai Shenhav, Carolyn K Dean Wolf, Uma R Karmarkar
Our most important decisions often provoke the greatest anxiety, whether we seek the better of two prizes or the lesser of two evils. Yet many of our choices are more mundane, such as selecting from a slate of mediocre but acceptable restaurants. Previous research suggests that choices of decreasing value should provoke decreasing anxiety. Here we show that this is not the case. Across three behavioral studies and one fMRI study, we find that anxiety and its neural correlates demonstrate a U-shaped function of choice set value, greatest when choosing between both the highest value and lowest value sets...
May 17, 2018: Journal of Experimental Psychology. General
Mohamed N Thabit, Mohamed A Sayed, Magda M Ali
PURPOSE: Epilepsy is a major public health problem worldwide. There are many misconceptions about people's knowledge and attitudes about epilepsy, which influence people's behavior towards patients with epilepsy. METHODS: We conducted a cross-sectional study in Sohag University, a public Egyptian University, in Upper Egypt. We used an Arabic language designed questionnaire to assess people's knowledge about epilepsy and their attitudes towards patients with epilepsy...
May 5, 2018: Epilepsy Research
Catherine Long, Nigel Curtis, Bridget Joan Freyne
No abstract text is available yet for this article.
May 10, 2018: Archives of Disease in Childhood
Aner Govrin
I describe the perception of evil as a categorization judgment, based on a prototype, with extensive feedback loops and top-down influences. Based on the attachment approach to moral judgment (Govrin, 2014, 2018), I suggest that the perception of evil consists of four salient features: Extreme asymmetry between victim and perpetrator; a specific perceived attitude of the perpetrator toward the victim's vulnerability; the observer's inability to understand the perpetrator's perspective; and insuperable differences between the observer and perpetrator's judgment following the incident which shake the observer no less than the event itself...
2018: Frontiers in Psychology
Charles Herbaux, Reid Merryman, Steven Devine, Philippe Armand, Roch Houot, Franck Morschhauser, Bradley Haverkos
PD-1 blockade is an effective therapy in relapsed/refractory (R/R) classical Hodgkin Lymphoma (cHL) who have relapsed after or are ineligible for autologous hematopoietic cell transplantation (HCT). While single-agent anti-PD-1 monoclonal antibodies (mAbs) are associated with high response rates and durable remissions, available results to date suggest that a large majority of patients will eventually progress on therapy. Many of these patients are potential candidates for allogeneic HCT (allo-HCT) after receiving anti-PD-1 mAbs, and allo-HCT remains for now the only treatment with demonstrated curative potential in this setting...
May 2, 2018: Blood
Martina Kelly, Tim Dornan, Tamara Pringsheim
BACKGROUND: Quetiapine is an antipsychotic that is widely prescribed off-label by family physicians despite evidence that safer alternatives exist. The aim of this research was to explore, in-depth, family physicians' reasons for this behaviour. METHODS: We conducted qualitative interviews with 15 urban family physicians in Alberta between October 2015 and April 2016. Participants were purposively selected based on sex, years of experience and practice type. Interviews explored participants' experiences prescribing quetiapine...
April 30, 2018: CMAJ Open
Lishu Chen, Dawei Wang, Yonghua Zhao
To explore the mechanism of acupoint embedding for obesity based on the western pathological mechanism of chronic low inflammatory response inducing the imbalance between"promoting inflammation"and"anti-inflammation"in immune reaction, and the pathological nature of deficient healthy qi and state of evil domination in the TCM theory induced by the"stagnation heat, phlegm heat, dampness heat, stasis heat"on the basis of qi deficiency. The mechanism may be improving the secretory disorder of adipose tissue and metabolic inflammatory response by the enhanced anti-inflammatory phagocytosis clearance ability in the immune system which is caused by the new inflammatory reaction under the stimulation of innate immune response pattern...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Suyun Li
There are connotations on regulating deficiency and excess by acupuncture reinforcing and reducing in Neijing ( the Internal Canon of Medicine ), including regulating yin and yang , regulating blood and qi , regulating weakened body resistance and state of evil domination, regulating the deficiency and excess of syndrome. The deficiency and excess usually mean the objects received reinforcing and reducing, such as tangible blood stasis, pus, water, etc, and invisible qi . The deficiency and excess had always mean the symptoms of diseases since Nanjing ( Classic of Questioning ), and the reinforcing and reducing of acupuncture was regulating qi ...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Ajaz Ahmad Waza, Zeenat Hamid, Sajad Ali, Shabir Ahmad Bhat, Musadiq Ahmad Bhat
Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising as a result of oxidative and inflammatory insults. Tremendous research has been carried out on HO-1 since years, pertaining its cytoprotective effect against oxidative injury and other cellular stresses. HO-1, by regulating intracellular levels of pro-oxidant heme, or by other benefits of its by-products such as carbon monoxide (CO) and biliverdin (BV) had become an important candidate protein to be up-regulated to combat diverse stressful events...
April 24, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Anastasia Lim, Hans W Hoek, Samrad Ghane, Mathijs Deen, Jan Dirk Blom
Background: Among Muslim patients, a common cultural concept of distress is the notion that jinn may be the cause of mental health problems, especially in the presence of hallucinations. Objective: This study examines the frequency with which this attribution style is manifest in a specific psychiatric outpatient population with a Muslim background. Methods: Of all patients registered at an outpatient clinic specialized in transcultural psychiatry, data were collected on folk belief, religion, hallucinations (if present), and medical diagnosis...
2018: Frontiers in Psychiatry
Cassiano R A F Diniz, Plinio C Casarotto, Leonardo Resstel, R L Joca Sâmia
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplasticity. In contrast, both precursor proBDNF and BDNF propeptide (another metabolic product from proBDNF cleavage) have a high affinity to p75 receptor (p75R) and usually convey apoptosis and neuronal shrinkage...
April 4, 2018: Neuroscience and Biobehavioral Reviews
Bhawana Aggarwal, Neerja Gupta
No abstract text is available yet for this article.
March 29, 2018: Indian Journal of Pediatrics
Bernhard Meier, Fabian Nietlispach
No abstract text is available yet for this article.
March 24, 2018: European Heart Journal
Seema Patel, Ahmad Homaei, Akondi Butchi Raju, Biswa Ranjan Meher
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, autoimmune, metabolic to degenerative. Both hypo and hyper level of estrogen has been linked to chronic and acute diseases...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Cornelis G Vos, Jean-Paul P M de Vries
No abstract text is available yet for this article.
March 20, 2018: European Journal of Vascular and Endovascular Surgery
Xiao-Xiao Lian, Xiao-Xia Guo
To investigate the herbal prescription rules of Professor Jiang Liangduo in the treatment of abdominal mass based on the traditional Chinese medicine inheritance support system software (TCMISS) of version 2.5, find out new herbal formulas for the treatment of abdominal mass, and then provide new reference to its traditional Chinese medicine therapy. By the method of retrospective study, one hundred and thirty-two outpatient prescriptions of Professor Jiang for the treatment of abdominal mass were collected to establish a typical database with TCMISS...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Edward H Reynolds
The word hysteria originated in the Corpus Hippocraticum (c420 BCE) as a natural explanation for a variety of diseases in women linked in the Greco-Roman mind to an animate or inanimate womb, but which in the last five centuries has evolved to describe an elusive disorder of brain ± mind in men and women, currently referred to by neurologists as "functional neurological disorder". The Babylonians, Assyrians and Egyptians had no knowledge of brain or psychological function. Babylonian and Assyrian descriptions of disease and behaviour include only rare examples suggestive of modern hysteria...
May 15, 2018: Journal of the Neurological Sciences
S C Donnelly
No abstract text is available yet for this article.
March 1, 2018: QJM: Monthly Journal of the Association of Physicians
Yi-Quan Yan, Juan Xie, Jing-Fu Wang, Zhao-Feng Shi, Xiang Zhang, Yong-Ping Du, Xing-Cheng Zhao
Hepatocellular carcinoma (HCC) is one of the most malignant diseases worldwide. The unfavorable clinical outcome and poor prognosis are due to high rates of recurrence and metastasis after treatments. Some scholars of traditional Chinese medicine suggested that endogenous wind-evil had played an important role in metastasis of malignant tumor. Therefore, the drug of dispelling wind-evil could be used to prevent cancer metastasis and improve the poor prognosis. So we wondered whether Scorpion, one of the most important wind calming drugs, has antitumor effect especially in epithelial-mesenchymal transition (EMT) and metastasis of HCC in this research...
April 2018: Experimental Biology and Medicine
Shizue Ohsawa, John Vaughen, Tatsushi Igaki
No abstract text is available yet for this article.
February 26, 2018: Developmental Cell
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