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https://www.readbyqxmd.com/read/29166495/photodynamic-action-of-the-red-laser-on-propionibacterium-acnes
#1
Rogério Rodrigo Ramos, Jeferson Leandro de Paiva, José Paulo Franco Dos Santos Gomes, Nagib Pezati Boer, José Maria Pereira de Godoy, Fernando Batigalia
BACKGROUND: Photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. OBJECTIVE: To evaluate the effect of red laser 660nm with the photosensitizer methylene blue on Propionibacterium acnes in vitro. METHOD: The experimental design was distributed into four groups (1 - control group without the application of light and without photosensitizer, 2 - application of light, 3 - methylene blue without light, and 4 - methylene blue with light)...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166200/effect-of-audiovisual-distraction-on-distress-and-oxygenation-status-in-children-receiving-aerosol-therapy
#2
Ni Luh Putu Shinta Devi, Nani Nurhaeni, Happy Hayati
Aerosol therapy, a treatment for children with disorders of the respiratory system, often causes distress, especially in young children. Distress during aerosol therapy can decrease the effectiveness of the treatment. This study aimed to determine the effect of audiovisual distraction on distress levels and oxygenation status (measured by oxygen saturation and respiratory frequency) in children who receive aerosol therapy for disorders of the respiratory system. A quasi-experimental design was employed, specifically a non-equivalent control group, pre-test-post-test design...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166194/the-effects-of-music-therapy-on-the-physiological-response-of-asthmatic-children-receiving-inhalation-therapy
#3
Riau Roslita, Nani Nurhaeni, Dessie Wanda
The clinical manifestation of asthma in children can interfere with their daily activities. Music therapy may become one of the alternative approaches to making children feel comfortable during inhalation therapy. The aim of the study was to identify the effects of music therapy on the physiological response of asthmatic preschool and school-age children receiving inhalation therapy. This study used a quasi-experimental, nonequivalent control group with a pre-test-post-test design. The 44 respondents consisted of preschool and school-age children assigned to intervention and control groups...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165872/manganese-dioxide-coated-ws2-fe3-o4-ssio2-nanocomposites-for-ph-responsive-mr-imaging-and-oxygen-elevated-synergetic-therapy
#4
Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attached...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29165777/the-use-of-crystalloids-in-traumatic-brain-injury
#5
Wojciech Dąbrowski, Tom Woodcock, Ziemowit Rzecki, Manu L N G Malbrain
Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypo- and hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. The current weight of evidence in the published literature suggests that albumin therapy is harmful and plasma substitutes have failed to demonstrate superiority over crystalloids solutions...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29165752/the-clinical-effects-of-combined-use-of-inhaled-nitric-oxide-at-early-stage-to-cure-severe-respiratory-failure-in-neonates
#6
W Wang, Z-G Li, G Liu, L Xue
OBJECTIVE: To observe the clinical effects of combined use of inhaled nitric oxide at the early stage to cure severe respiratory failure in neonates. PATIENTS AND METHODS: 45 cases of neonates with severe respiratory failure, who were admitted to the neonatal intensive care unit (NICU) of XuZhou Children's Hospital from November 2014 to February 2016, were selected as objects of study, namely the iNO treatment group. On the basis of conventional treatment and mechanical ventilation, all of them were treated with the combined use of iNO at the early stage...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165393/the-role-of-hypoxia-in-glioblastoma-invasion
#7
REVIEW
Ana Rita Monteiro, Richard Hill, Geoffrey J Pilkington, Patrícia A Madureira
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 to 17 months. The current treatment for GBM involves tumor resection surgery based on MRI image analysis, followed by radiotherapy and treatment with temozolomide. However, the gradual development of tumor resistance to temozolomide is frequent in GBM patients leading to subsequent tumor regrowth/relapse. For this reason, the development of more effective therapeutic approaches for GBM is of critical importance...
November 22, 2017: Cells
https://www.readbyqxmd.com/read/29164803/preclinical-evaluation-and-optimization-of-a-cell-therapy-using-human-cord-blood-derived-endothelial-colony-forming-cells-for-ischemic-retinopathies
#8
Emma Reid, Jasenka Guduric-Fuchs, Christina L O'Neill, Lynsey-Dawn Allen, Sarah E J Chambers, Alan W Stitt, Reinhold J Medina
Cell therapy using endothelial progenitors holds promise for vascular repair in ischemic retinopathies. Using a well-defined subpopulation of human cord blood-derived endothelial progenitors known as endothelial colony-forming cells (ECFCs), we have evaluated essential requirements for further development of this cell therapy targeting the ischemic retina, including dose response, delivery route, and toxicity. First, to evaluate therapeutic efficacy relating to cell dose, ECFCs were injected into the vitreous of mice with oxygen-induced retinopathy...
November 22, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29164478/excited-state-and-non-linear-optical-properties-of-nir-absorbing-%C3%AE-thiophene-fused-bf2-azadipyrromethene-dyes-computational-investigation
#9
Yogesh Gawale, Lydia Rhyman, Mohamed I Elzagheid, Ponnadurai Ramasami, Nagaiyan Sekar
Density functional theory and time-dependent density functional theory computations were used to understand the electronic and photophysical parameters of NIR β-thiophene-fused BF2-azadipyrromethene dyes. The computed data are in good agreement with those obtained experimentally and they provide insights into the origin of red shifted optical spectra compared to the parent aza-BODIPY, low Stokes shift, non-linear optical responses and quantitative description of the singlet-triplet energy gap. The resultant decrease in the HOMO - LUMO energy gap is responsible for the red shift...
November 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29164403/a-novel-photodynamic-therapy-based-drug-delivery-system-layered-on-a-stent-for-treating-cholangiocarcinoma
#10
Po-Chin Liang, Kai-Wen Huang, Chien-Chih Tung, Ming-Chu Chang, Fuh-Yu Chang, Jau-Min Wong, Yu-Ting Chang
This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers...
November 22, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29164394/combination-of-nad-and-nadph-offers-greater-neuroprotection-in-ischemic-stroke-models-by-relieving-metabolic-stress
#11
Qiao Huang, Meiling Sun, Mei Li, Dingmei Zhang, Feng Han, Jun Chao Wu, Kohji Fukunaga, Zhong Chen, Zheng-Hong Qin
Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD(+)) have been reported to have potent neuroprotective effects against ischemic neuronal injury. Both NADPH and NAD(+) are essential cofactors for anti-oxidation and cellular energy metabolism. We investigated if combined NADPH and NAD(+) could offer better neuroprotective effects on cellular and animal models of ischemic stroke. In vitro studies with primary cultured neurons demonstrated that NAD(+) was effective in protecting neurons against oxygen-glucose deprivation/reoxygenation (OGD/R) injury when given during the early time period of reoxygenation...
November 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29164187/fluorous-photosensitizers-enhance-photodynamic-therapy-with-perfluorocarbon-nanoemulsions
#12
Rachael A Day, Daniel A Estabrook, Jessica K Logan, Ellen M Sletten
Photodynamic therapy (PDT) requires a photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and a photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT.
November 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29163184/silencing-of-nac1-expression-induces-cancer-cells-oxidative-stress-in-hypoxia-and-potentiates-the-therapeutic-activity-of-elesclomol
#13
Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu, Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang
In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear protein of the BTB/POZ gene family, has pivotal roles in cancer development. Here, we identified that NAC1-PDK3 axis as necessary for suppression of mitochondrial function, oxygen consumption, and more harmful ROS generation and protects cancer cells from apoptosis in hypoxia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163050/mechanisms-of-cisplatin-induced-ototoxicity-and-otoprotection
#14
REVIEW
Sandeep Sheth, Debashree Mukherjea, Leonard P Rybak, Vickram Ramkumar
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants as otoprotective agents. Later studies show that ROS could stimulate cochlear inflammation, suggesting the use of anti-inflammatory agents for treatment of hearing loss...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29162863/pulse-frequency-dependency-of-photobiomodulation-on-the-bioenergetic-functions-of-human-dental-pulp-stem-cells
#15
Hong Bae Kim, Ku Youn Baik, Pill-Hoon Choung, Jong Hoon Chung
Photobiomodulation (PBM) therapy contributes to pain relief, wound healing, and tissue regeneration. The pulsed wave (PW) mode has been reported to be more effective than the continuous wave (CW) mode when applying PBM to many biological systems. However, the reason for the higher effectiveness of PW-PBM is poorly understood. Herein, we suggest using delayed luminescence (DL) as a reporter of mitochondrial activity after PBM treatment. DL originates mainly from mitochondrial electron transport chain systems, which produce reactive oxygen species (ROS) and adenosine triphosphate (ATP)...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162066/effect-of-sivelestat-sodium-in-patients-with-acute-lung-injury-or-acute-respiratory-distress-syndrome-a-meta-analysis-of-randomized-controlled-trials
#16
Shenglan Pu, Daoxin Wang, Daishun Liu, Yan Zhao, Di Qi, Jing He, Guoqi Zhou
BACKGROUND: Sivelestat is widely used in treating acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), although the clinical efficacy of sivelestat remains controversial. This study aimed to evaluate the impact of sivelestat in patients with ALI/ARDS. METHODS: Electronic databases, PubMed, Embase, and the Cochrane Library, were searched to identify trials through April 2017. Randomized controlled trials (RCTs) were included irrespective of blinding or language that compared patients with and without sivelestat therapy in ALI/ARDS...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29161882/redox-active-quinones-chelators-as-possible-antitumor-drugs-properties-mechanisms-of-action-cells-delivery-and-cells-toxicity
#17
Nikolaj Polyakov, Tatyana Leshina, Lidiya Fedenok, Irina Slepneva, Igor A Kirilyuk, Justina Furso, Magdalena M Olchawa, Tadeusz Sarna, Martyna Elas, Itzhak Bilkis, Lev Weiner
SIGNIFICANCE: Chemotherapy is currently the principal method for treating many malignancies. Thus, development of improved antitumor drugs with enhanced efficacy and selectivity remains a high priority. Recent Advances: Anthracycline antibiotics (AAs), e.g., doxorubicin, daunomycin, and mitomycin C, are an important family of antitumor agents widely used in chemotherapy. All these compounds are quinones. They are thus capable of being reduced by appropriate chemicals or reductases. One of their important properties is that under aerobic conditions their reduced forms undergo oxidation, with concomitant production of reactive oxygen species (ROS), i...
November 22, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29161401/the-evolution-of-airway-management-new-concepts-and-conflicts-with-traditional-practice
#18
A F McNarry, A Patel
In the last 25 yr, there have been several advances in the safe management of the airway. Videolaryngoscopes and supraglottic airways, now in routine use by new trainees in anaesthesia, have had their genesis in the recent past. The 4th National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society published in 2011 a seminal report that has influenced airway management worldwide . Understanding how the report's recommendations were constructed and how clinical guidelines compliment rather than contradict them is important in understanding the tenets of safe airway management...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161007/polymer-based-technologies-for-sensing-applications
#19
Wildemar Stefanio Pereira Carvalho, Menglian Wei, Nduka Ikpo, Yongfeng Gao, Michael J Serpe
Reports in the literature on the development of new chemical sensing technologies have been growing steadily in number for years. For example, a Web of Science topic search using the term "Chemical Sensing" revealed that over 8,000 papers were published in 2015-2017, with over 40,000 citations to those papers. In this review, we focus on highlighting recent examples of chemical sensing related to human health (e.g., disease diagnosis, health monitoring, and water/food safety), and for environmental monitoring...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160836/an-in-vitro-study-of-the-photodynamic-effectiveness-of-go-ag-nanocomposites-against-human-breast-cancer-cells
#20
Fozia Shaheen, Muhammad Hammad Aziz, Muhammad Fakhar-E-Alam, Muhammad Atif, Mahvish Fatima, Riaz Ahmad, Atif Hanif, Saqib Anwar, Fatima Zafar, Ghazanfar Abbas, Syed Mansoor Ali, Mukhtar Ahmed
Graphene-based materials have garnered significant attention because of their versatile bioapplications and extraordinary properties. Graphene oxide (GO) is an extremely oxidized form of graphene accompanied by the functional groups of oxygen on its surface. GO is an outstanding platform on which to pacify silver nanoparticles (Ag NPs), which gives rise to the graphene oxide-silver nanoparticle (GO-Ag) nanocomposite. In this experimental study, the toxicity of graphene oxide-silver (GO-Ag) nanocomposites was assessed in an in vitro human breast cancer model to optimize the parameters of photodynamic therapy...
November 21, 2017: Nanomaterials
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