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https://www.readbyqxmd.com/read/29705270/nuclear-progestin-receptor-pgr-knockouts-resulted-in-subfertility-in-male-tilapia-oreochromis-niloticus
#1
Xuelian Fang, Limin Wu, Lanying Yang, Lingyun Song, Jing Cai, Feng Luo, Jing Wei, Linyan Zhou, Deshou Wang
It was documented that 17α, 20β-dihydroxy-4-pregnen-3-one (DHP), a fish specific progestin, might play critical roles in spermatogenesis, sperm maturation and spermiation partially through activating nuclear receptor (Pgr). However, no direct evidence is available to demonstrate the functions of DHP in fish spermatogenesis. To further elucidate the roles of DHP in teleosts, we generated a pgr homozygous mutant line in XY Nile tilapia (Oreochromis niloticus). Pgr gene mutation resulted in the development of a smaller, thinner testis and a lower GSI compared with normal testis...
April 26, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29617818/fshb-211-g-t-is-a-major-genetic-modulator-of-reproductive-physiology-and-health-in-childbearing-age-women
#2
Kristiina Rull, Marina Grigorova, Aivar Ehrenberg, Pille Vaas, Aire Sekavin, Diana Nõmmemees, Mart Adler, Ele Hanson, Peeter Juhanson, Maris Laan
STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associated with serum FSH, LH and anti-Müllerian hormone (AMH) levels in reproductive age women, their menstrual cycle parameters and risk of infertility? SUMMARY ANSWER: Only the FSHB -211 G>T variant was a major genetic determinant of serum gonadotropin levels in both, eumenorrheic healthy women and female infertility patients, and the T-allele carrier status was enriched among idiopathic infertility cases...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29579177/fshb-knockout-mouse-model-two-decades-later-and-into-the-future
#3
T Rajendra Kumar
In 1997, nearly 20 years ago now, we first reported the phenotypes of follicle-stimulating hormone beta (Fshb) null mice. Since then, these mice have been useful for various physiological and genetic studies in reproductive and skeletal biology. In a 2009 review entitled "FSHβ knockout mouse model: a decade ago and into the future", I summarized the need for and what led to the development of a FSH-deficient mouse model and its applications including delineation of the then emerging extra-gonadal roles of FSH in bone cells using this genetic model...
March 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29534107/regulation-of-fsh-expression-by-differentially-expressed-mir-186-5p-in-rat-anterior-adenohypophyseal-cells
#4
Dong-Xu Han, Yue Xiao, Chang-Jiang Wang, Hao Jiang, Yan Gao, Bao Yuan, Jia-Bao Zhang
Follicle-stimulating hormone (FSH) has key roles in animal reproduction, including spermatogenesis and ovarian maturation. Many factors influence FSH secretion. However, despite the broad functions of microRNAs (miRNAs) via the regulation of target genes, little is known about their roles in FSH secretion. Our previous results suggested that miR-186-5p targets the 3' UTR of FSHb; therefore, we examined whether miR-186-5p could regulate FSH secretion in rat anterior adenohypophyseal cells. miR-186-5p was transfected into rat anterior pituitary cells...
2018: PloS One
https://www.readbyqxmd.com/read/29496550/seasonal-variation-of-pituitary-gonadotropin-subunit-brain-type-aromatase-and-sex-steroid-receptor-mrnas-and-plasma-steroids-during-gametogenesis-in-wild-sablefish
#5
José M Guzmán, J Adam Luckenbach, Denis A M da Silva, Edward S Hayman, Gina M Ylitalo, Frederick W Goetz, Penny Swanson
Pituitary-hormone signaling plays critical roles in the onset and progression of gametogenesis in vertebrates. This study characterized expression patterns of pituitary gonadotropin beta-subunits (fshb and lhb), brain-type aromatase (cyp19a1b), androgen (ar1, ar2) and estrogen receptors (esr1, esr2a, esr2b), and changes in plasma steroid levels by liquid chromatography/tandem mass spectrometry in wild sablefish (Anoplopoma fimbria, order Scorpaeniformes) during a complete reproductive cycle. Transcripts for fshb increased during early gametogenesis and peaked in late vitellogenic females and late recrudescent males, while expression of lhb reached maximum levels in periovulatory and spermiating fish...
May 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29487567/regulatory-architecture-of-the-l%C3%AE-t2-gonadotrope-cell-underlying-the-response-to-gonadotropin-releasing-hormone
#6
Frederique Ruf-Zamojski, Miguel Fribourg, Yongchao Ge, Venugopalan Nair, Hanna Pincas, Elena Zaslavsky, German Nudelman, Stephanie J Tuminello, Hideo Watanabe, Judith L Turgeon, Stuart C Sealfon
The LβT2 mouse pituitary cell line has many characteristics of a mature gonadotrope and is a widely used model system for studying the developmental processes and the response to gonadotropin-releasing hormone (GnRH). The global epigenetic landscape, which contributes to cell-specific gene regulatory mechanisms, and the single-cell transcriptome response variation of LβT2 cells have not been previously investigated. Here, we integrate the transcriptome and genome-wide chromatin accessibility state of LβT2 cells during GnRH stimulation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29486146/identification-and-functional-characterization-of-two-secretogranin-ii-genes-in-orange-spotted-grouper-epinephelus-coioides
#7
Hu Shu, Lidong Yang, Yong Zhang, Xiaochun Liu, Haoran Lin, Shuisheng Li
Secretoneurin (SN) is an important stimulator of pituitary luteinizing hormone (LH) synthesis and secretion in goldfish. It is unknown whether this neuropeptide performs the same role in other fish species. In this study, the full-length cDNAs encoding Secretogranin IIa (SgIIa) and b (SgIIb) were cloned from the brain of orange-spotted grouper. Sequence analysis showed that a 34-amino acid SN peptide (SNa) is present in SgIIa proprotein, and a 33-amino acid SN peptide (SNb) is present in SgIIb proprotein. The two SN peptides share a low degree of similarity but contain the signature YTPQ-X-LA-X7 -EL sequence...
May 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29471436/antiandrogen-treatment-ameliorates-reproductive-and-metabolic-phenotypes-in-the-letrozole-induced-mouse-model-of-pcos
#8
Genevieve E Ryan, Shaddy Malik, Pamela L Mellon
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone, anovulation, and obesity. In the current study, we sought to determine whether androgen receptor (AR) actions are responsible for any of the phenotypes observed in LET mice...
April 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29438534/both-in-vivo-fsh-depletion-and-follicular-exposure-to-gonadotrophin-releasing-hormone-analogues-in-vitro-are-not-effective-to-prevent-follicular-depletion-during-chemotherapy-in-mice
#9
F Horicks, G Van Den Steen, C Gervy, H J Clarke, I Demeestere
STUDY QUESTION: Does fertility preservation using gonadotrophin-releasing hormone (GnRH) analogues during chemotherapy act through a direct effect on the ovary or through inhibition of FSH secretion? SUMMARY ANSWER: The absence of FSH in vivo and the direct exposition of ovarian follicles to GnRH analogues in vitro did not prevent chemotherapy-induced ovarian damage. WHAT IS KNOWN ALREADY: The potential mechanisms of action of GnRH analogues in protecting ovaries against chemotherapy damage remain poorly understood...
April 1, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29326840/reproductive-gene-expression-in-a-coral-reef-fish-exposed-to-increasing-temperature-across-generations
#10
Heather D Veilleux, Jennifer M Donelson, Philip L Munday
Reproduction in marine fish is generally tightly linked with water temperature. Consequently, when adults are exposed to projected future ocean temperatures, reproductive output of many species declines precipitously. Recent research has shown that in the common reef fish, Acanthochromis polyacanthus , step-wise exposure to higher temperatures over two generations (parents: +1.5°C, offspring: +3.0°C) can improve reproductive output in the F2 generation compared to F2 fish that have experienced the same high temperatures over two generations (F1 parents: +3...
2018: Conservation Physiology
https://www.readbyqxmd.com/read/29259254/identification-of-long-non-coding-rnas-in-the-immature-and-mature-rat-anterior-pituitary
#11
Dong-Xu Han, Xu-Lei Sun, Yao Fu, Chang-Jiang Wang, Jian-Bo Liu, Hao Jiang, Yan Gao, Cheng-Zhen Chen, Bao Yuan, Jia-Bao Zhang
Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. However, a systematic analysis of lncRNAs expressed at different developmental stages of normal pituitary, particularly in rats, has not been performed. Therefore, we contrasted two cDNA libraries of immature (D15) and mature (D120) anterior pituitary in rat that were sequenced on an Illumina HiSeq Xten platform, and a total of 29,568,806,352 clean reads were identified...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210006/triiodothyronine-differentially-modulates-the-lh-and-fsh-synthesis-and-secretion-in-male-rats
#12
Renata Marino Romano, Paula Bargi-Souza, Erika Lia Brunetto, Francemilson Goulart-Silva, Renato M Salgado, Telma Maria Tenorio Zorn, Maria Tereza Nunes
Hypothyroidism and thyrotoxicosis produce adverse effects in male reproduction by unknown mechanisms. We investigated whether triiodothyronine (T3) modulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) synthesis/secretion, by inducing different thyroid states. In hypothyroidism, the content of Lhb and Fshb mRNAs was increased, while their association to ribosomes and the protein content were reduced and the serum LH and FSH concentrations were augmented and decreased, respectively. Thyrotoxicosis reduced Lhb mRNA and LH serum concentration, and increased Lhb mRNA translational rate...
January 2018: Endocrine
https://www.readbyqxmd.com/read/29179257/is-the-fshr-2039a-g-variant-associated-with-susceptibility-to-testicular-germ-cell-cancer
#13
A K Bang, A S Busch, K Almstrup, J Gromoll, S Kliesch, E Rajpert-De Meyts, N E Skakkebaek, A Juul, F Tüttelmann, N Jørgensen
Testicular germ cell cancer (TGCC) is derived from germ cell neoplasia in situ (GCNIS), which arises due to niche disturbances affecting the Sertoli cells. It is believed that exogenous endocrine factors have a crucial role in governing neoplastic transformation but on a strong hereditary background. Follicle-stimulating hormone (FSH) is the major regulatory hormone of the Sertoli cells. FSH signalling-related single-nucleotide polymorphisms (SNPs) have previously been shown to affect FSH action in men at different levels...
January 2018: Andrology
https://www.readbyqxmd.com/read/29077908/differential-impact-of-genetic-loci-on-age-at-thelarche-and-menarche-in-healthy-girls
#14
Alexander S Busch, Casper P Hagen, Maria Assens, Katharina M Main, Kristian Almstrup, Anders Juul
Context: Recent genetic studies have identified genetic variants associated with age at pubertal onset. Whereas genome-wide association studies reported associations of several hundred genetic variants with timing of self-reported age at menarche, a recent clinical study focused on genetic variation affecting follicle-stimulating hormone action and clinically determined age at thelarche. The observations appear to be incongruent, as effect sizes varied substantially among the studies...
January 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29065928/chromatin-status-and-transcription-factor-binding-to-gonadotropin-promoters-in-gonadotrope-cell-lines
#15
Huimin Xie, Hanne M Hoffmann, Anita K Iyer, Melissa J Brayman, Cindy Ngo, Mary Jean Sunshine, Pamela L Mellon
BACKGROUND: Proper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to expression of the glycoproteins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), we characterized chromatin structure changes, imparted mainly by histone modifications, in model gonadotrope cell lines. METHODS: We evaluated chromatin status and gene expression profiles by chromatin immunoprecipitation assays, DNase sensitivity assay, and RNA sequencing in three developmentally staged gonadotrope cell lines, αT1-1 (progenitor, expressing Cga), αT3-1 (immature, expressing Cga and Gnrhr), and LβT2 (mature, expressing Cga, Gnrhr, Lhb, and Fshb), to assess changes in chromatin status and transcription factor access of gonadotrope-specific genes...
October 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29055862/juvenile-exposure-to-bisphenol-a-promotes-ovarian-differentiation-but-suppresses-its-growth-potential-involvement-of-pituitary-follicle-stimulating-hormone
#16
Weiting Chen, Shuk-Wa Lau, Yuqin Fan, Rudolf S S Wu, Wei Ge
Bisphenol A (BPA), a plastic monomer and plasticizer, is commonly used in plastics industry, and it has been well documented to be an estrogenic endocrine disrupter. In the present study, we investigated the effect of early (juvenile) exposure to BPA on the hypothalamic-pituitary-gonad (HPG) axis in the zebrafish. Estradiol (E2) and testosterone (T) were also included as positive and negative controls respectively. Juvenile zebrafish were exposed to BPA (1 and 10μM), E2 (10nM) and T (10nM) from 20 to 40 dpf (days post-fertilization), the period of sex/gonadal differentiation, followed by histological and expression analyses at 40 dpf...
December 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28974703/sex-steroid-production-associated-with-puberty-is-absent-in-germ-cell-free-salmon
#17
Lene Kleppe, Eva Andersson, Kai Ove Skaftnesmo, Rolf B Edvardsen, Per Gunnar Fjelldal, Birgitta Norberg, Jan Bogerd, Rüdiger W Schulz, Anna Wargelius
In all vertebrates studied so far, germ cells are not required for pubertal maturation of the gonadal steroidogenic system, subsequent development of secondary sex characteristics and reproductive behavior. To explore if the absence of germ cells affects puberty or growth in Atlantic salmon, germ cell-free (GCF), dnd knockout and wild type (WT) postsmolts were stimulated to enter puberty. No GCF fish entered puberty, whereas 66.7% (males) and 30% (females) WT fish completed or entered puberty, respectively...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28972919/reproductive-effects-of-synthetic-progestin-norgestrel-in-zebrafish-danio-rerio
#18
Yan-Qiu Liang, Guo-Yong Huang, Zhong Lin, Jin Li, Jie-Wen Yang, Lai-Yuan Zhong, Guang-Guo Ying
The aim of this study was to assess the adverse effects of synthetic progestin norgestrel (NGT) on the reproduction of zebrafish by measuring the egg production, histology and transcriptional expression profiles along the hypothalamic-pituitary-gonadal (HPG) axis in adult zebrafish. After a pre-exposure period of 7 days, adult zebrafish were exposed to 6, 29 and 69 ng L-1 NGT for 21 days. The results showed that exposure to 69 ng L-1 NGT led to a significant up-regulation of follicle stimulating hormone, beta polypeptide (fshb), luteinizing hormone, beta polypeptide (lhb), progesterone receptor (pgr), estrogen receptor 1 (esr1) and androgen receptor (ar) genes in the brains, as well as significant up-regulation of hydroxysteroid 20-beta dehydrogenase (hsd20b) and hydroxysteroid 11-beta dehydrogenase 2 (hsd11b2) genes and down-regulation of 11-beta-hydroxylase (cyp11b) gene in the ovaries of females...
January 2018: Chemosphere
https://www.readbyqxmd.com/read/28964731/time-and-dose-related-effects-of-a-gonadotropin-releasing-hormone-agonist-and-dopamine-antagonist-on-reproduction-in-the-northern-leopard-frog-lithobates-pipiens
#19
Maria Vu, Bradley Weiler, Vance L Trudeau
Gonadotropin-releasing hormone (GnRH) stimulates luteinizing hormone release to control ovulation and spermiation in vertebrates. Dopamine (DA) has a clear inhibitory role in the control of reproduction in numerous teleosts, and emerging evidence suggests that similar mechanisms may exist in amphibians. The interactions between GnRH and DA on spawning success and pituitary gene expression in the Northern leopard frog (Lithobates pipiens) were therefore investigated. Frogs were injected during the natural breeding season with a GnRH agonist [GnRH-A; (Des-Gly10 , D-Ala6 , Pro-NHEt9 )-LHRH; 0...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28901453/the-role-of-gene-polymorphisms-in-endometriosis
#20
Michail Matalliotakis, Maria I Zervou, Charoula Matalliotaki, Nilufer Rahmioglu, George Koumantakis, Ioannis Kalogiannidis, Ioannis Prapas, Krina Zondervan, Demetrios A Spandidos, Ioannis Matalliotakis, George N Goulielmos
Endometriosis is a benign gynecologic disorder, affecting up to 10% of women, characterized by the presence of functional endometrial tissue at ectopic positions generally within the peritoneum. It is a heritable condition influenced by multiple genetic and environmental factors, with an overall heritability estimated at approximately 50%. In this study, we investigated whether single nucleotide polymorphisms (SNPs) rs7521902, rs10859871 and rs11031006, mapping to WNT4, VEZT and FSHB genetic loci, respectively, are associated with risk for endometriosis in a Greek population...
November 2017: Molecular Medicine Reports
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