keyword
MENU ▼
Read by QxMD icon Read
search

Fshb

keyword
https://www.readbyqxmd.com/read/28611209/the-highly-overlapping-actions-of-lh-signaling-and-fsh-signaling-on-zebrafish-spermatogenesis
#1
Yuxin Xie, Lianhe Chu, Yun Liu, Kathy W Y Sham, Jianzhen Li, Christopher H K Cheng
Gonadotropin signaling plays a pivotal role in the spermatogenesis of vertebrates, but how gonadotropins regulate the process in non-mammalian species remains elusive. Using a gene knockout approach in zebrafish, we have previously demonstrated the non-canonical action of gonadotropin signaling on spermatogenesis by analyzing four single mutant lines (lhb, lhr, fshb and fshr) and three double mutant lines (lhb;fshb, lhr;fshr and fshb;lhr). In this study, we further investigated the actions of gonadotropins on the testis by establishing three other double mutant zebrafish lines (lhb;lhr, fshb;fshr and lhb;fshr)...
June 13, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28601516/exposure-to-e2-and-ee2-environmental-concentrations-affect-different-components-of-the-brain-pituitary-gonadal-axis-in-pejerrey-fish-odontesthes-bonariensis
#2
Ángela Gárriz, Pamela S Del Fresno, Leandro A Miranda
The present study focuses on the effects of E2 and EE2 environmental concentrations on different components of the reproductive axis of pejerrey (Odontesthes bonariensis), a native fish species from Pampas lakes of Argentina. The results obtained demonstrated that E2 and EE2 separate or mixed, could disrupt key pathways of the pejerrey Brain-Pituitary-Gonadal axis. First, it was observed that at the brain level, gnrh-III and cyp19a1b mRNA expression increased significantly in the exposed fish. Secondly, in the pituitary fshb and lhb mRNA expression levels, the study did not show any differences between treated and control groups...
June 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28537267/meta-analysis-identifies-five-novel-loci-associated-with-endometriosis-highlighting-key-genes-involved-in-hormone-metabolism
#3
Yadav Sapkota, Valgerdur Steinthorsdottir, Andrew P Morris, Amelie Fassbender, Nilufer Rahmioglu, Immaculata De Vivo, Julie E Buring, Futao Zhang, Todd L Edwards, Sarah Jones, Dorien O, Daniëlle Peterse, Kathryn M Rexrode, Paul M Ridker, Andrew J Schork, Stuart MacGregor, Nicholas G Martin, Christian M Becker, Sosuke Adachi, Kosuke Yoshihara, Takayuki Enomoto, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Michiaki Kubo, Gudmar Thorleifsson, Reynir T Geirsson, Unnur Thorsteinsdottir, Leanne M Wallace, Jian Yang, Digna R Velez Edwards, Mette Nyegaard, Siew-Kee Low, Krina T Zondervan, Stacey A Missmer, Thomas D'Hooghe, Grant W Montgomery, Daniel I Chasman, Kari Stefansson, Joyce Y Tung, Dale R Nyholt
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10(-8)), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1 and FSHB)...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28506471/genetics-of-gonadotropins-and-their-receptors-as-markers-of-ovarian-reserve-and-response-in-controlled-ovarian-stimulation
#4
REVIEW
Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Daniele Santi, Giulia Brigante, Manuela Simoni, Livio Casarini
Several controlled ovarian stimulation (COS) protocols have been developed to increase the yield of mature oocytes retrieved in assisted reproductive techniques (ARTs). The ovarian reserve (OR) influences the COS response, and it represents the main parameter that helps clinicians in refining clinical treatments in the perspective of a "personalized" ART. This approach is even more needed in particular conditions such as poor OR or polycystic ovary syndrome. Follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin are currently used in COS at different combinations and with different efficacies, even if the best approach definition is controversial...
April 17, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28402262/roles-of-differential-expression-of-microrna-21-3p-and-microrna-433-in-fsh-regulation-in-rat-anterior-pituitary-cells
#5
Dong-Xu Han, Xu-Lei Sun, Ming-Qiang Xu, Cheng-Zhen Chen, Hao Jiang, Yan Gao, Bao Yuan, Jia-Bao Zhang
Follicle-stimulating hormone (FSH) secreted by adenohypophyseal cells plays an important role in the regulation of reproduction, but whether microRNAs (miRNAs) regulate the secretion of FSH remains unclear. In the present study, we predicted and screened miRNAs that might act on the follicle-stimulating hormone beta-subunit (FSHb) gene of rats using the TargetScan program and luciferase reporter assays, and the results identified two miRNAs, miR-21-3p and miR-433. We then transfected these miRNAs into rat anterior adenohypophyseal cells and assessed the FSHb expression levels in and FSH secretion by the transfected cells through quantitative PCR and ELISA...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28385888/modeling-and-high-throughput-experimental-data-uncover-the-mechanisms-underlying-fshb-gene-sensitivity-to-gonadotropin-releasing-hormone-pulse-frequency
#6
Estee Stern, Frederique Ruf-Zamojski, Lisa Zalepa-King, Hanna Pincas, Soon Gang Choi, Charles S Peskin, Fernand Hayot, Judith L Turgeon, Stuart C Sealfon
Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms. GnRH regulates the pituitary gonadotropin's follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique β subunits (FSHβ/LHβ). Contrary to Lhb, Fshb gene induction has a preference for low-frequency GnRH pulses. To clarify the underlying regulatory mechanisms, we developed three biologically anchored mathematical models: 1) parallel activation of Fshb inhibitory factors (e...
June 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28330973/neurokinin-b-regulates-reproduction-via-inhibition-of-kisspeptin-in-a-teleost-the-striped-bass
#7
Nilli Zmora, Ten-Tsao Wong, John Stubblefield, Berta Levavi-Sivan, Yonathan Zohar
Kisspeptin and neurokinin B (NKB) are neuropeptides co-expressed in the mammalian hypothalamus and coordinately control GnRH signaling. We have found that Nkb and kisspeptin neurons are distinct in the teleost, striped bass (STB) and capitalized on this phenomenon to study the mode of action of Nkb and its related neuropeptide-F (Nkf), both of which are encoded by the tac3 gene. In vitro brain slices and in vivo administration studies revealed that Nkb/f consistently downregulated kiss2, whereas antagonist (AntD) administration restored this effect...
May 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28323923/genetic-variation-of-follicle-stimulating-hormone-action-is-associated-with-age-at-testicular-growth-in-boys
#8
Alexander S Busch, Casper P Hagen, Katharina M Main, Anita Pereira, Camila Corvalan, Kristian Almstrup, Veronica Mericq, Anders Juul
Context: Although genetic factors play a pivotal role in male pubertal timing, genome-wide association studies have identified only a few loci. Genetic variation of follicle-stimulating hormone (FSH) action affects adult reproductive parameters and female pubertal timing. Objective: To investigate whether genetic variation affecting FSH action is associated with onset of puberty in boys. Design: Cross-sectional and longitudinal study of two cohorts of healthy boys...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#9
Thangal Yumnamcha, Zeeshan A Khan, Chongtham Rajiv, Sijagurumayum D Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
May 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28281143/impact-of-the-fshb-gene-211g-t-polymorphism-on-male-gonadal-function
#10
L Tamburino, S La Vignera, V Tomaselli, R A Condorelli, L M Mongioì, A E Calogero
PURPOSE: The FSHB gene -211G/T polymorphism has been reported to modulate gene expression and to cause inter-individual differences in FSH serum levels in men. This study was undertaken to assess the functional relevance of this polymorphism on gonadotropin and total testosterone serum levels and sperm parameters in men from Eastern Sicily (Italy). METHODS: To accomplish this, 200 men with abnormal conventional sperm parameters or normozoospermia (according to the parameters of WHO 2010) were genotyped by TaqMan Assay...
May 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28262687/the-syndrome-of-central-hypothyroidism-and-macroorchidism-igsf1-controls-trhr-and-fshb-expression-by-differential-modulation-of-pituitary-tgf%C3%AE-and-activin-pathways
#11
Marta García, Raquel Barrio, Montserrat García-Lavandeira, Angela R Garcia-Rendueles, Adela Escudero, Esther Díaz-Rodríguez, Darya Gorbenko Del Blanco, Ana Fernández, Yolanda B de Rijke, Elena Vallespín, Julián Nevado, Pablo Lapunzina, Vilborg Matre, Patricia M Hinkle, Anita C S Hokken-Koelega, María P de Miguel, José Manuel Cameselle-Teijeiro, Manuel Nistal, Clara V Alvarez, José C Moreno
IGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear. Based on a patient with a full deletion of IGSF1 clinically followed from neonate to adulthood, we investigated a common pituitary origin for hypothyroidism and macroorchidism, and the role of IGSF1 as regulator of pituitary hormone secretion. The patient showed congenital central hypothyroidism with reduced TSH biopotency, over-secretion of FSH at neonatal minipuberty and macroorchidism from 3 years of age...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28242307/molecular-identification-of-the-dyn-kor-system-and-its-potential-role-in-the-reproductive-axis-of-goldfish
#12
Yali Liu, Shuisheng Li, Qing Wang, Yu Chen, Xin Qi, Yun Liu, Xiaochun Liu, Haoran Lin, Yong Zhang
To ascertain the significance of the dynorphin/kappa-opioid receptor (Dyn/Kor) system in fish reproduction, prodynorphin (pdyn) cDNA was cloned from goldfish. Two Dyn peptides (DynA and DynB) are present in the goldfish prodynorphin precursor. Both DynA and DynB are biologically active as they are able to functionally interact with the goldfish Kor expressed in cultured eukaryotic cells to suppress forskolin-induced CRE promoter activity. RT-PCR analysis showed that pdyn is widely expressed in brain regions, with the highest expression in hypothalamus...
February 24, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28219785/transcriptional-alterations-induced-by-binary-mixtures-of-ethinylestradiol-and-norgestrel-during-the-early-development-of-zebrafish-danio-rerio
#13
Yan-Qiu Liang, Guo-Yong Huang, Jian-Liang Zhao, Wen-Jun Shi, Li-Xin Hu, Fei Tian, Shuang-Shuang Liu, Yu-Xia Jiang, Guang-Guo Ying
Synthetic estrogens and progestins are commonly used in human and veterinary medicine. After use, they reach aquatic environments via discharge of wastewaters from human and animals, thus posing potential risks to organisms. So far, very little is known about their combined effects in aquatic organisms. The aim of this study was to investigate the effects of binary mixtures of ethinylestradiol (EE2) and norgestrel (NGT) on embryonic zebrafish (Danio rerio) by measuring transcriptional alterations. Zebrafish embryos were exposed to EE2 and NGT alone or in combination at concentrations between 36 and 5513ngL(-1) for 96h post-fertilization (hpf)...
May 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28197776/effects-of-melanocortin-4-receptor-agonists-and-antagonists-on-expression-of-genes-related-to-reproduction-in-spotted-scat-scatophagus-argus
#14
Dong-Neng Jiang, Jian-Tao Li, Ya-Xiong Tao, Hua-Pu Chen, Si-Ping Deng, Chun-Hua Zhu, Guang-Li Li
Melanocortin-4 receptor (Mc4r) function related to reproduction in fish has not been extensively investigated. Here, we report on gene expression changes by real-time PCR following treatment with Mc4r agonists and antagonists in the spotted scat (Scatophagus argus). Using in vitro incubated hypothalamus, the Mc4r nonselective agonist NDP-MSH ([Nle(4), D-Phe(7)]-α-melanocyte stimulating hormone; 10(-6) M) and selective agonist THIQ (N-[(3R)-1, 2, 3, 4-Tetrahydroisoquinolinium-3-ylcarbonyl]- (1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl) piperidin-1-yl]-2-oxoethylamine; 10(-7) M) significantly increased the expression of gnrh (Gonadotropin releasing hormone), while the Mc4r nonselective antagonist SHU9119 (Ac-Nle-[Asp-His-DPhe/DNal(2')-Arg-Trp-Lys]-NH2; 10(-6) M) and selective antagonist Ipsen 5i (compound 5i synthesized in Ipsen Research Laboratories; 10(-6) M) significantly inhibited gnrh expression after 3 h of incubation...
February 14, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28195137/erbb4-confers-risk-for-polycystic-ovary-syndrome-in-han-chinese
#15
Yingqian Peng, Wei Zhang, Ping Yang, Ye Tian, Shizhen Su, Changming Zhang, Zi-Jiang Chen, Han Zhao
A recent genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in European cohorts has identified six susceptibility loci mapping to 11q22.1 (YAP1), 2p21 (THADA), 11p14.1 (FSHB), 2q34 (ERBB4), 12q21.2 (KRR1), and 5q31.1 (RAD50). The loci of 11q22.1, 2p21 and 11p14.1 have been confirmed to be associated with PCOS in Chinese; whereas the other three new loci (2q34, 12q21.2, and 5q31.1) still need to be evaluated in Chinese. This study was aimed to determine if the three new loci identified in European PCOS also confer risks for PCOS in Han Chinese...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068351/phenotype-and-tissue-expression-as-a-function-of-genetic-risk-in-polycystic-ovary-syndrome
#16
Cindy T Pau, Tim Mosbruger, Richa Saxena, Corrine K Welt
Genome-wide association studies and replication analyses have identified (n = 5) or replicated (n = 10) DNA variants associated with risk for polycystic ovary syndrome (PCOS) in European women. However, the causal gene and underlying mechanism for PCOS risk at these loci have not been determined. We hypothesized that analysis of phenotype, gene expression and metformin response as a function of genotype would identify candidate genes and pathways that could provide insight into the underlying mechanism for risk at these loci...
2017: PloS One
https://www.readbyqxmd.com/read/27998941/mir-361-3p-regulates-fsh-by-targeting-fshb-in-a-porcine-anterior-pituitary-cell-model
#17
Rui-Song Ye, Meng Li, Chao-Yun Li, Qi-En Qi, Ting Chen, Xiao Cheng, Songbo Wang, Gang Shu, Li-Na Wang, Xiao-Tong Zhu, Qingyan Jiang, Qian-Yun Xi, Yong-Liang Zhang
FSH plays an essential role in processes involved in human reproduction, including spermatogenesis and the ovarian cycle. While the transcriptional regulatory mechanisms underlying its synthesis and secretion have been extensively studied, little is known about its post-transcriptional regulation. A bioinformatics analysis from our group indicated that a microRNA (miRNA; miR-361-3p) could regulate FSH secretion by potentially targeting the FSHB subunit. Herein, we sought to confirm these findings by investigating the miR-361-3p-mediated regulation of FSH production in primary pig anterior pituitary cells...
December 20, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27994055/smad3-regulates-follicle-stimulating-hormone-synthesis-by-pituitary-gonadotrope-cells-in-vivo
#18
Yining Li, Gauthier Schang, Ulrich Boehm, Chu-Xia Deng, Jonathan Graff, Daniel J Bernard
Pituitary follicle-stimulating hormone (FSH) is an essential regulator of fertility in females and of quantitatively normal spermatogenesis in males. Pituitary-derived activins are thought to act as major stimulators of FSH synthesis by gonadotrope cells. In vitro, activins signal via SMAD3, SMAD4, and forkhead box L2 (FOXL2) to regulate transcription of the FSHβ subunit gene (Fshb). Consistent with this model, gonadotrope-specific Smad4 or Foxl2 knock-out mice have greatly reduced FSH and are subfertile. The role of SMAD3 in vivo is unresolved; however, residual FSH production in Smad4 conditional knock-out mice may derive from partial compensation by SMAD3 and its ability to bind DNA in the absence of SMAD4...
February 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27940043/gonadotropin-subunits-of-the-characiform-astyanax-altiparanae-molecular-characterization-spatiotemporal-expression-and-their-possible-role-on-female-reproductive-dysfunction-in-captivity
#19
Lázaro Wender O de Jesus, Jan Bogerd, Felipe M Vieceli, Giovana S Branco, Marília P Camargo, Mônica Cassel, Renata G Moreira, Chao Y I Yan, Maria I Borella
To better understand the endocrine control of reproduction in Characiformes and the reproductive dysfunctions that commonly occur in migratory fish of this order when kept in captivity, we chose Astyanax altiparanae, which has asynchronous ovarian development and multiple spawning events, as model species. From A. altiparanae pituitary total RNA, we cloned the full-length cDNAs coding for the follicle-stimulating hormone β subunit (fshb), the luteinizing hormone β subunit (lhb), and the common gonadotropin α subunit (gpha)...
May 15, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27916574/temperature-affects-sexual-maturation-through-the-control-of-kisspeptin-kisspeptin-receptor-gnrh-and-gth-subunit-gene-expression-in-the-grass-puffer-during-the-spawning-season
#20
Md Shahjahan, Takashi Kitahashi, Hironori Ando
Water temperature is an environmental factor of primary importance that influences reproductive function in fish. To understand the molecular and physiological mechanisms underlying the regulation of reproduction by temperature, we examined changes in expression of genes encoding kisspeptin (kiss2), kisspeptin receptor (kiss2r) and three gonadotropin-releasing hormones (gnrh1, gnrh2 and gnrh3) in the brain and genes encoding gonadotropin (GTH) subunits (gpa, fshb and lhb) in the pituitary of grass puffer exposed to a low temperature (14°C), normal temperature (21°C) and high temperature (28°C) for 7days...
March 1, 2017: General and Comparative Endocrinology
keyword
keyword
37733
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"