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https://www.readbyqxmd.com/read/27904931/-arthroscopic-tenodesis-or-tenotomy-of-the-long-head-of-the-biceps-tendon-in-preselected-patients-does-it-make-a%C3%A2-difference
#1
M Kerschbaum, N Maziak, M Scheuermann, M Scheibel
BACKGROUND: Are there clinical, cosmetic and/or structural differences between tenotomy and tenodesis of the long head of the biceps tendon (LHB) in patients selected according to commonly used indication criteria? MATERIAL AND METHODS: A total of 85 patients were included in this study. An LHB tenodesis (LHB-TD) was performed in 49 patients and a tenotomy (LHB-TT) in 36 patients. In addition to a standardized examination, the age and gender adjusted Constant score (aCS), the LHB score and the subjective shoulder value (SSV) were assessed...
November 30, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27885409/-simultaneous-surgical-treatment-of-the-long-head-of-the-biceps-tendon-during-operative-treatment-of-proximal-humeral-fractures
#2
M Kerschbaum, M Werth, C Gerhardt, M Scheibel
BACKGROUND: Pathologic conditions of the long biceps tendon can be found within treatment of proximal humeral fractures or as a source of pain after surgery. However, simultaneous surgical treatment at the index surgical intervention is so far not well established. The purpose of this study is to evaluate the results of a simultaneous biceps treatment during plate osteosynthesis of proximal humeral fractures. MATERIALS AND METHODS: Twenty-seven patients were included into this study...
November 24, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27872807/identification-of-the-stria-medullaris-thalami-using-diffusion-tensor-imaging
#3
Ryan B Kochanski, Robert Dawe, Daniel B Eddelman, Mehmet Kocak, Sepehr Sani
BACKGROUND: Deep brain stimulation (DBS) via anatomical targeting of white matter tracts defined by diffusion tensor imaging (DTI) may be a useful tool in the treatment of pathologic neurophysiologic circuits implicated in certain disease states like treatment resistant depression (TRD). We sought to determine if DTI could be used to define the stria medullaris thalami (SM), the major afferent white matter pathway to the lateral habenula (LHb), a thalamic nucleus implicated in the pathophysiology of TRD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27865867/d1-like-dopamine-receptor-dysfunction-in-the-lateral-habenula-nucleus-increased-anxiety-like-behavior-in-rat
#4
Jiangping Chan, Yiling Ni, Pengyue Zhang, Yanmei Chen, Jichuan Zhang
Lateral habenula (LHb) is important for emotional processing. It is a link node between forebrain and midbrain. LHb is reciprocally connected with ventral tegmental area, acting as a regulatory center for the dopaminergic system. However, the role of dopamine receptors in the LHb in emotional processing is less clear. In the present study, the expression of dopamine D1 and D2 receptors in LHb was testified by western blot. In addition, D1- or D2-like receptor agonist or antagonist was bilaterally administered into the LHb, anxiety-like and depressive-like behaviors were tested 15min later in rats...
November 16, 2016: Neuroscience
https://www.readbyqxmd.com/read/27862283/footshock-induced-plasticity-of-gabab-signalling-in-the-lateral-habenula-requires-dopamine-and-glucocorticoid-receptors
#5
Salvatore Lecca, Massimo Trusel, Manuel Mameli
The activity of lateral habenula (LHb) represents a substrate for the encoding of negative-valenced events. The exposure to aversive stimuli in naïve mice is sufficient to trigger a reduction in GABAB -mediated signaling in the LHb. This is ultimately instrumental for the hyperactivity of LHb neurons and for the establishment of depressive-like phenotypes. However, the mechanisms responsible for the induction of this aversion-driven plasticity are missing. Using ex-vivo patch-clamp recordings in slices, here we show that exposing mice to a series of inescapable footshocks (FsE) rapidly reduces baclofen-mediated GABAB currents in the LHb...
November 10, 2016: Synapse
https://www.readbyqxmd.com/read/27854152/identification-of-four-snps-in-lhb-gene-and-their-associations-with-sperm-qualities-of-chinese-buffaloes
#6
Yunyun Cheng, Jiaming Gu, Han Xue, Qiang Li, Mingming Liang, Nan Wang, Gang Wang, Qingyan Wu, Songcai Liu, Hao Yu, Jiabao Zhang, Linlin Hao
Luteinizing hormone beta polypeptide (LHB) gene has been considered important for sexual behavior and has associations with sperm quality. In this study, four SNPs (g.276 T>C, g.377A>C, g.401T>C, and g.412A>G) were detected in the LHB gene of 165 water buffaloes by direct sequencing and identification of overlap peaks, each of which was associated with at least one sperm quality trait of ejaculate volume, sperm concentration, post-thaw sperm motilities, and sperm abnormalities by chi-square analysis...
November 17, 2016: Animal Biotechnology
https://www.readbyqxmd.com/read/27830690/-detection-of-novel-genetic-markers-of-susceptibility-to-preeclampsia-based-on-an-analysis-of-the-regulatory-genes-in-the-placental-tissue
#7
V N Serebrova, E A Trifonova, T V Gabidulina, I Yu Bukharina, T A Agarkova, I D Evtushenko, N R Maksimova, V A Stepanov
Regulatory single nucleotide polymorphisms (rSNPs) are the least-studied group of SNP; however, they play an essential role in the development of human pathology by altering the level of candidate genes expression. In this work, we analyzed 29 rSNPs in 17 new candidate genes associated with preeclampsia (PE) according to the analysis of the transcriptome in placental tissue. Three ethnic groups have been studied (yakut, russian, and buryat). We have detected significant associations of PE with eight rSNPs in six differentially expressed genes, i...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27822183/can-the-lateral-habenula-crack-the-serotonin-code
#8
REVIEW
Anna Tchenio, Kristina Valentinova, Manuel Mameli
The lateral habenula (LHb) and the serotonergic system both contribute to motivational states by encoding rewarding and aversive signals. Converging evidence suggests that perturbation of these systems is critical for the pathophysiology of mood disorders. Anatomical and functional studies indicate that the serotonergic system and the LHb are interconnected in a forward-feedback loop. However, how serotonin release modifies the synaptic and cellular properties of LHb neurons and whether this has any behavioral repercussions remain poorly investigated...
2016: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/27813530/involvement-of-infralimbic-prefrontal-cortex-but-not-lateral-habenula-in-dopamine-attenuation-after-chronic-mild-stress
#9
Jared L Moreines, Zoe L Owrutsky, Anthony A Grace
Emerging evidence supports a role for dopamine in major depressive disorder (MDD). We recently reported fewer spontaneously active ventral tegmental area (VTA) dopamine neurons (ie reduced dopamine neuron population activity) in the chronic mild stress (CMS) rodent model of MDD. In this study, we examine the role of two brain regions that have been implicated in MDD in humans, the infralimbic prefrontal cortex (ILPFC)-ie rodent homologue of Brodmann Area 25 (BA25), and the lateral habenula (LHb), in the CMS-induced attenuation of dopamine neuron activity...
November 4, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27803150/gonadotropin-characterization-localization-and-expression-inthe-european-hake-merluccius-merluccius
#10
Michela Candelma, Romain Fontaine, Sabrina Colella, Alberto Santojanni, Finn-Arne Weltzien, Oliana Carnevali
In vertebrates, the regulation of gametogenesis is under the control of gonadotropins (Gth), follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh). In fish, the physiological role of Gths is not fully understood, especially in species with asynchronous ovarian development. In order to elucidate the role of Gths in species with asynchronous ovary, we studied European hake (Merluccius merluccius) during the reproductive season. For this aim, we first cloned and sequenced both hormones. Then, we characterized their amino acid sequence and performed phylogenetic analyses to verify the relationship to their orthologues in other species...
November 1, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27785462/activation-of-a-habenulo-raphe-circuit-is-critical-for-the-behavioral-and-neurochemical-consequences-of-uncontrollable-stress-in-the-male-rat
#11
Samuel D Dolzani, Michael V Baratta, Jose Amat, Kara L Agster, Michael P Saddoris, Linda R Watkins, Steven F Maier
Exposure to uncontrollable stress [inescapable tailshock (IS)] produces behavioral changes that do not occur if the stressor is controllable [escapable tailshock (ES)] an outcome that is mediated by greater IS-induced dorsal raphe nucleus (DRN) serotonin [5-hydroxytryptamine (5-HT)] activation. It has been proposed that this differential activation occurs because the presence of control leads to top-down inhibition of the DRN from medial prefrontal cortex (mPFC), not because uncontrollability produces greater excitatory input...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27732891/lesions-of-the-lateral-habenula-facilitate-active-avoidance-learning-and-threat-extinction
#12
Mihee Song, Yong Sang Jo, Yeon-Kyung Lee, June-Seek Choi
The lateral habenula (LHb) is an epithalamic brain structure that provides strong projections to midbrain monoaminergic systems that are involved in motivation, emotion, and reinforcement learning. LHb neurons are known to convey information about aversive outcomes and negative prediction errors, suggesting a role in learning from aversive events. To test this idea, we examined the effects of electrolytic lesions of the LHb on signaled two-way active avoidance learning in which rats were trained to avoid an unconditioned stimulus (US) by taking a proactive shuttling response to an auditory conditioned stimulus (CS)...
October 11, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27682823/excitation-of-lateral-habenula-neurons-as-a-neural-mechanism-underlying-ethanol-induced-conditioned-taste-aversion
#13
Shashank Tandon, Kristen A Keefe, Sharif A Taha
KEY POINTS: The lateral habenula (LHb) has been implicated in regulation of drug-seeking behaviours through aversion-mediated learning. In this study, we recorded neuronal activity in the LHb of rats during an operant task before and after ethanol-induced conditioned taste aversion (CTA) to saccharin. Ethanol-induced CTA caused significantly higher baseline firing rates in LHb neurons, as well as elevated firing rates in response to cue presentation, lever press and saccharin taste. In a separate cohort of rats, we found that bilateral LHb lesions blocked ethanol-induced CTA...
September 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27678415/ethanol-potentiates-both-gabaergic-and-glutamatergic-signaling-in-the-lateral-habenula
#14
Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Ye
Ethanol's aversive property may limit it's use, but the underlying mechanisms are no well-understood. Emerging evidence suggests a critical role for the lateral habenula (LHb) in the aversive response to various drugs, including ethanol. We previously showed that ethanol enhances glutamatergic transmission and stimulates LHb neurons. GABAergic transmission, a major target of ethanol in many brain regions, also tightly regulates LHb activity. This study assessed the action of ethanol on LHb GABAergic transmission in rat brain slices...
September 25, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27623306/high-frequency-stimulation-of-the-subthalamic-nucleus-modulates-neuronal-activity-in-the-lateral-habenula-nucleus
#15
Henrike Hartung, Sonny K H Tan, Yasin Temel, Trevor Sharp
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is often used to treat movement disability in advanced Parkinson's disease, but some patients experience debilitating psychiatric effects including depression. Interestingly, HFS of the STN modulates 5-HT neurons in the dorsal raphe nucleus (DRN) which are linked to depression, but the neural substrate of this effect is unknown. Here, we tested the effect of STN stimulation on neuronal activity in the lateral habenula nucleus (LHb), an important source of input to DRN 5-HT neurons and also a key controller of emotive behaviours...
September 13, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27621460/illusory-late-heavy-bombardments
#16
Patrick Boehnke, T Mark Harrison
The Late Heavy Bombardment (LHB), a hypothesized impact spike at ∼3.9 Ga, is one of the major scientific concepts to emerge from Apollo-era lunar exploration. A significant portion of the evidence for the existence of the LHB comes from histograms of (40)Ar/(39)Ar "plateau" ages (i.e., regions selected on the basis of apparent isochroneity). However, due to lunar magmatism and overprinting from subsequent impact events, virtually all Apollo-era samples show evidence for (40)Ar/(39)Ar age spectrum disturbances, leaving open the possibility that partial (40)Ar* resetting could bias interpretation of bombardment histories due to plateaus yielding misleadingly young ages...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27616647/reproductive-toxicity-of-azoxystrobin-to-adult-zebrafish-danio-rerio
#17
Fangjie Cao, Lizhen Zhu, Hui Li, Song Yu, Chengju Wang, Lihong Qiu
In the past few decades, extensive application of azoxystrobin has led to great concern regarding its adverse effects on aquatic organisms. The objective of the present study was to evaluate the reproductive toxicity of azoxystrobin to zebrafish. After adult zebrafish of both sexes were exposed to 2, 20 and 200 μg/L azoxystrobin for 21 days, egg production, the fertilization rate, the gonadosomatic index (GSI) and hepatosomatic index (HSI), 17β-estradiol (E2), testosterone (T) and vitellogenin (Vtg) concentrations, and histological alterations in the gonads and livers were measured...
September 8, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27599831/outcomes-following-long-head-of-biceps-tendon-tenodesis
#18
REVIEW
Saad M AlQahtani, Ryan T Bicknell
Lesions of the proximal long head of the biceps tendon (LHB) have been considered as a major cause of shoulder pain and dysfunction. The role of the LHB in causing pain has been a source of controversy for many years, and extensive literature is available discussing anatomy, function, pathology, and most importantly appropriate treatment. Despite this, there is a lack of consensus in the literature regarding the management of biceps-related pathology. Biceps tenotomy and tenodesis are common surgical treatment options when dealing with LHB-related pathology...
December 2016: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/27596561/nicotine-regulates-activity-of-lateral-habenula-neurons-via-presynaptic-and-postsynaptic-mechanisms
#19
Wanhong Zuo, Cheng Xiao, Ming Gao, F Woodward Hopf, Krešimir Krnjević, J Michael McIntosh, Rao Fu, Jie Wu, Alex Bekker, Jiang-Hong Ye
There is much interest in brain regions that drive nicotine intake in smokers. Interestingly, both the rewarding and aversive effects of nicotine are probably critical for sustaining nicotine addiction. The medial and lateral habenular (LHb) nuclei play important roles in processing aversion, and recent work has focused on the critical involvement of the LHb in encoding and responding to aversive stimuli. Several neurotransmitter systems are implicated in nicotine's actions, but very little is known about how nicotinic acetylcholine receptors (nAChRs) regulate LHb activity...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27577549/long-head-biceps-tenodesis-or-tenotomy-in-arthroscopic-rotator-cuff-repair-bite-study-protocol
#20
Derek Friedrich Petrus van Deurzen, Vanessa Antoinet Bernice Scholtes, Nienke Willemien Willigenburg, Navin Gurnani, Lukas Pieter Eduard Verweij, Michel Pieter Jozef van den Bekerom
BACKGROUND: Optimal treatment of the diseased long head of the biceps (LHB) tendon during rotator cuff repair remains a topic of debate: tenotomy or tenodesis. A recent meta analysis revealed no difference in strength or functional outcome between treatments. The included studies varied in methodological quality, and only two were randomized controlled trials (RCTs). As strong evidence in favor of either tenotomy or tenodesis is still lacking, we designed this randomized controlled trial to compare functional outcomes after tenotomy and tenodesis when performed in adjunct to arthroscopic rotator cuff repair...
2016: BMC Musculoskeletal Disorders
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