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https://www.readbyqxmd.com/read/28353062/self-reported-long-term-cardiac-morbidity-in-breast-cancer-patients-a-retrospective-cohort-study-in-germany-passos-heart-study
#1
Daniel Wollschläger, Hiltrud Merzenich, Lukas Schwentner, Wolfgang Janni, Thomas Wiegel, Detlef Bartkowiak, Achim Wöckel, Marcus Schmidt, Heinz Schmidberger, Maria Blettner
PURPOSE: Improved survival after locoregional breast cancer has increased the concern about late adverse effects after therapy. In particular, radiotherapy was identified as a risk factor for major cardiac events in women treated until the 1990s. While modern radiotherapy with computerized planning based on 3D-imaging can help spare organs at risk, heart exposure may remain substantial. In a retrospective cohort study of women treated for locoregional breast cancer, we investigated whether current radiotherapy is associated with an elevated long-term cardiac morbidity risk...
March 28, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28336316/effects-of-age-and-soybean-isoflavones-on-hepatic-cholesterol-metabolism-and-thyroid-hormone-availability-in-acyclic-female-rats
#2
Branka Šošić-Jurjević, Dieter Lütjohann, Ivana Jarić, Marko Miler, Danijela Vojnović Milutinović, Branko Filipović, Vladimir Ajdžanović, Kostja Renko, Eva Katrin Wirth, Snežana Janković, Josef Kӧhrle, Verica Milošević
Soy-food and its isoflavones, genistein (G) and daidzein (D), were reported to exert mild cholesterol-lowering effect, but the underlying mechanism is still unclear. In this research, first we studied age-related alterations in hepatic cholesterol metabolism of acyclic middle-aged (MA) female rats. Then we tested if purified isoflavones may prevent or reverse these changes, and whether putative changes in hepatic thyroid hormone availability may be associated with this effect. Serum and hepatic total cholesterol (TChol), bile acid and cholesterol precursors, as well as serum TSH and T4 concentrations, hepatic deiodinase (Dio) 1 enzyme activity and MCT8 protein expression were determined by comparing data obtained for MA with young adult (YA) intact (IC) females...
June 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28259714/protective-effect-of-losartan-and-ramipril-against-stress-induced-insulin-resistance-and-related-complications-anti-inflammatory-mechanisms
#3
Barinder Singh, Ashish Mourya, Sangeeta Pilkhwal Sah, Anil Kumar
Chronic restraint stress (CRS) is known to cause various behavioural and biochemical alterations, leading to several negative health outcomes. The present study was designed to explore the impact of inhibiting Renin angiotensin aldosterone system (RAAS) and inflammatory pathways in stress pathophysiology. In the present study, male LACA mice were subjected to restraint stress daily for 30 days. Losartan, nimesulide, ramipril, minocycline and their combinations were administered 45min prior to restraint stress daily and their effects were observed...
April 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28211910/link-between-plasminogen-activator-inhibitor-1-and-cardiovascular-risk-in-chronic-hepatitis-c-after-viral-clearance
#4
Ming-Ling Chang, Yu-Sheng Lin, Li-Heng Pao, Hsin-Chih Huang, Cheng-Tang Chiu
The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Multivariate analysis demonstrated, before anti-HCV-therapy, platelet count and PAI-1-rs1799889 genotype were associated with PAI-1 levels. Among patients with a sustained virological response (SVR, n = 445), platelet count was associated with PAI-1 level at 24 weeks post-therapy...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27973607/serum-sphingosine-1-phosphate-concentrations-are-inversely-associated-with-atherosclerotic-diseases-in-humans
#5
Irina Soltau, Eileen Mudersbach, Markus Geissen, Edzard Schwedhelm, Martin S Winkler, Maria Geffken, Sven Peine, Gerhard Schoen, E Sebastian Debus, Axel Larena-Avellaneda, Guenter Daum
BACKGROUND AND OBJECTIVES: Atherosclerotic changes of arteries are the leading cause for deaths in cardiovascular disease and greatly impair patient's quality of life. Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates potentially pro-as well as anti-atherogenic processes. Here, we investigate whether serum-S1P concentrations are associated with peripheral artery disease (PAD) and carotid stenosis (CS). METHODS AND RESULTS: Serum was sampled from blood donors (controls, N = 174) and from atherosclerotic patients (N = 132) who presented to the hospital with either clinically relevant PAD (N = 102) or CS (N = 30)...
2016: PloS One
https://www.readbyqxmd.com/read/27566674/the-role-of-active-brown-adipose-tissue-abat-in-lipid-metabolism-in-healthy-chinese-adults
#6
Xiaoliang Shao, Wei Yang, Xiaonan Shao, Chun Qiu, Xiaosong Wang, Yuetao Wang
BACKGROUND: The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism. METHODS: We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis...
August 26, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27494444/prevalence-of-potential-familial-hypercholesteremia-fh-in-54-811-statin-treated-patients-in-clinical-practice
#7
Alberico L Catapano, Dominik Lautsch, Lale Tokgözoglu, Jean Ferrieres, Martin Horack, Michel Farnier, Peter P Toth, Philippe Brudi, Joanne E Tomassini, Baishali Ambegaonkar, Anselm K Gitt
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a life-threatening disease, characterized by elevated LDL-C levels and a premature, increased risk of coronary heart disease (CHD) that is globally underdiagnosed. The percentage of patients with possible or probable FH in various countries was examined in the Dyslipidemia International Study (DYSIS). METHODS: DYSIS is a multinational, cross-sectional observational study of 54,811 adult outpatients treated with statin therapy...
September 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27389630/vaccine-strategies-for-lowering-ldl-by-immunization-against-proprotein-convertase-subtilisin-kexin-type-9
#8
Bryce Chackerian, Alan Remaley
PURPOSE OF REVIEW: mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of hypercholesterolemia. However, one major drawback of mAb-based therapy for a chronic condition like dyslipidemia is its relatively high cost. This review summarizes two recent studies describing novel vaccine approaches for lowering LDL-cholesterol by active immunization against PCSK9. RECENT FINDINGS: PCSK9 is a plasma protein secreted by the liver that controls cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the LDL receptor...
August 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27298669/acute-myocardial-infarction-in-a-26-year-old-patient-with-familial-hypercholesteremia
#9
Takeshi Miyayama, Shin-Ichiro Miura, Tomo Komaki, Takashi Kuwano, Joji Morii, Hiroaki Nishikawa, Keijiro Saku
A 26-year-old male suffered sustained chest pain. Electrocardiogram showed ST-segment elevation in the anteroseptal wall and reciprocal ST-segment change in the inferior wall. The troponin-I level and the white blood cell count were elevated. We gave a diagnosis of acute myocardial infarction. He underwent urgent coronary angiography, which revealed 90% diffuse stenosis in the middle right coronary artery and total occlusion in the proximal left anterior descending coronary artery (LAD). Since the electrocardiogram indicated that the culprit lesion was in the proximal LAD, we performed percutaneous coronary intervention...
July 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27228696/-modern-conceptions-about-the-possible-impact-of-palm-oil-on-human-health
#10
REVIEW
O S Medvedev, N A Medvedeva
Review of the scientific literature on the evidence of the relationship between palm oil (PO) and its components and adverse effects on human health, on the mechanisms of cholesterol control and risks for development of cardiovascular diseases. PO is solid or semisolid at room temperature and often is used as a natural substitute for partially hydrogenated vegetable oils containing trans fatty acids which increase risks of hypercholesteremia. PO contains both saturated and unsaturated fats as well as substances with antioxidant activity...
2016: Voprosy Pitaniia
https://www.readbyqxmd.com/read/27177316/treatment-interruption-after-2-year-antiretroviral-treatment-initiated-during-acute-early-hiv-in-infancy
#11
Dalton Wamalwa, Sarah Benki-Nugent, Agnes Langat, Kenneth Tapia, Evelyn Ngugi, Helen Moraa, Elizabeth Maleche-Obimbo, Vincent Otieno, Irene Inwani, Barbra A Richardson, Bhavna Chohan, Julie Overbaugh, Grace C John-Stewart
OBJECTIVE: Treatment interruption has been well tolerated and durable in some pediatric studies but none have compared treatment interruption with continued antiretroviral treatment (ART) following ART initiation in early HIV. The objective of this study was to compare outcomes in treatment interruption versus continued ART among early-treated infants. DESIGN: Randomized trial (OPH-03; NCT00428116). METHODS: The trial included HIV-infected infants who initiated ART at less than 13 months of age, received ART for 24 months, and, if eligible (CD4% >25%, normal growth), were randomized to treatment interruption versus continued ART...
September 24, 2016: AIDS
https://www.readbyqxmd.com/read/26632690/end-stage-renal-disease-as-a-potential-risk-factor-for-retinal-vein-occlusion
#12
San-Ni Chen, Te-Cheng Yang, Jian-Teng Lin, Ie-Bin Lian
End stage renal disease (ESRD) has been reported to be an important risk factor for systemic vascular disease. Retinal vein occlusion (RVO) is closely related with cardiovascular diseases; however, its association with ESRD had not been reported. The aim of the study was to investigate whether ESRD is a risk factor for RVO, including central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). This population-based study is based on the longitudinal data from Taiwan National Health Insurance Research Database...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25983325/spontaneous-and-diet-aggravated-hemolysis-and-its-correction-by-probucol-in-sr-bi-knockout-mice-with-ldl-r-deficiency
#13
Jiawei Liao, Mingming Gao, Mengyu Wang, Xin Guo, Wei Huang, George Liu
BACKGROUND: High density lipoprotein receptor SR-BI plays a vital role in cholesterol homeostasis. Depletion of SR-BI causes plasma free cholesterol (FC) accumulation, which disrupts erythrocytes membrane and might induce hemolytic anemia. Here we explored the effects of hypercholesteremia, induced by depletion of low density lipoprotein receptor (LDL-R) and high fat diet (HFD) feeding, on plasma FC and possible hemolysis in SR-BI knockout (KO) mice, and the therapeutic effects of a lipid-lowering drug probucol...
July 17, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25880842/clonorchis-sinensis-acetoacetyl-coa-thiolase-identification-and-characterization-of-its-potential-role-in-surviving-in-the-bile-duct
#14
Jinsi Lin, Hongling Qu, Guishan Chen, Lei He, Yanquan Xu, Zhizhi Xie, Mengyu Ren, Jiufeng Sun, Shan Li, Wenjun Chen, Xueqing Chen, Xiaoyun Wang, Xuerong Li, Chi Liang, Yan Huang, Xinbing Yu
BACKGROUND: Clonorchis sinensis (C. sinensis) inhabits in bile duct of the host. However, the mechanisms involved in why C. sinensis can survive in the bile environment containing lipids have not yet been explored. In this study, C. sinensis acetoacetyl-CoA thiolase (CsACAT), a member of the thiolase family which has a key role in the beta oxidation pathway of fatty acid production, was identified and characterized to understand its potential role in adapting to the bile environment. METHODS: The encoding sequence, conserved domains and spatial structure of CsACAT were identified and analyzed by bioinformatic tools...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25779265/clonorchis-sinensis-acetoacetyl-coa-thiolase-identification-and-characterization-of-its-potential-role-in-surviving-in-the-bile-duct
#15
Jinsi Lin, Hongling Qu, Guishan Chen, Lei He, Yanquan Xu, Zhizhi Xie, Mengyu Ren, Jiufeng Sun, Shan Li, Wenjun Chen, Xueqing Chen, Xiaoyun Wang, Xuerong Li, Chi Liang, Yan Huang, Xinbing Yu
BACKGROUND: Clonorchis sinensis (C. sinensis) inhabits in bile duct of the host. However, the mechanisms involved in why C. sinensis can survive in the bile environment containing lipids have not yet been explored. In this study, C. sinensis acetoacetyl-CoA thiolase (CsACAT), a member of the thiolase family which has a key role in the beta oxidation pathway of fatty acid production, was identified and characterized to understand its potential role in adapting to the bile environment. METHODS: The encoding sequence, conserved domains and spatial structure of CsACAT were identified and analyzed by bioinformatic tools...
December 2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25624570/animal-models-of-erectile-dysfunction
#16
REVIEW
Snehlata V Gajbhiye, Kshitij S Jadhav, Padmaja A Marathe, Dattatray B Pawar
Animal models have contributed to a great extent to understanding and advancement in the field of sexual medicine. Many current medical and surgical therapies in sexual medicine have been tried based on these animal models. Extensive literature search revealed that the compiled information is limited. In this review, we describe various experimental models of erectile dysfunction (ED) encompassing their procedures, variables of assessment, advantages and disadvantages. The search strategy consisted of review of PubMed based articles...
January 2015: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/25586614/exercise-protects-against-pcb-induced-inflammation-and-associated-cardiovascular-risk-factors
#17
Margaret O Murphy, Michael C Petriello, Sung Gu Han, Manjula Sunkara, Andrew J Morris, Karyn Esser, Bernhard Hennig
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that contribute to the initiation of cardiovascular disease. Exercise has been shown to reduce the risk of cardiovascular disease; however, whether exercise can modulate PCB-induced vascular endothelial dysfunction and associated cardiovascular risk factors is unknown. We examined the effects of exercise on coplanar PCB-induced cardiovascular risk factors including oxidative stress, inflammation, impaired glucose tolerance, hypercholesteremia, and endothelium-dependent relaxation...
February 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/25382353/low-serum-adiponectin-levels-are-associated-with-reduced-insulin-sensitivity-and-lipid-disturbances-in-short-children-born-small-for-gestational-age
#18
Yuefang Huang, Yanhong Li, Qiuli Chen, Hongshan Chen, Huamei Ma, Zhe Su, Minlian Du
BACKGROUND: Being born as small for gestational age (SGA) has an increased risk of developing metabolic/cardiovascular disturbances in later life. The role of adiponectin in the metabolic disturbance in SGA children remained undefined. OBJECTIVE: The aim of this study was to investigate the association between serum levels of adiponectin and insulin sensitivity as well as lipid profile in short children born SGA at prepubertal ages. PATIENTS AND METHODS: Serum levels of adiponectin, fasting glucose, insulin, IGF-I, IGFBP-1, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein A-I (ApoA-I) and Apo B were measured in 30 prepubertal short children born SGA...
July 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25339541/robinetinidol-flavone-attenuates-cholesterol-synthesis-in-hepatoma-cells-via-inhibition-of-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase
#19
Hai Niu, Yu Chao, Ke Li, Junxiang Li, Weihong Gong, Wen Huang
Robinetinidol-(4β,2')-tetrahydroxy-flavone (RBF) is an oligomeric condensed polyphenol that has been shown to exhibit anti-obesity effects in mice. However, little is know regarding its effect on cholesterol synthesis. The present study therefore aimed to investigate the effect of RBF on cholesterol synthesis. It was determined that RBF decreased serum total cholesterol and low density lipoprotein cholesterol in rats by 25.9 and 50.8%, respectively (P<0.001). These results strengthen evidence for the hypothesis that RBF exerts anti-atherogenic effects in vivo...
January 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25300997/upregulated-expression-of-human-alpha-defensins-1-2-and-3-in-hypercholesteremia-and-its-relationship-with-serum-lipid-levels
#20
Yun-Xi Li, Chao-Qun Lin, Da-Yu Shi, Shu-Ying Zeng, Wen-Sheng Li
Human alpha-defensins are natural antimicrobial peptides of neutrophils evolved in host defense reactions and circulating nonstressed alpha-defensins may be associated with serum lipid levels. The aim of this work was to examine whether the expression of alpha-defensins 1, 2 and 3 genes are changed and whether this changes are reversed following treatment in patients with hypercholesteremia. A total of 40 individuals of hypercholesteremia group were studied, compared with 40 individuals of normal control group...
November 2014: Human Immunology
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