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https://www.readbyqxmd.com/read/29792191/cost-of-provision-of-opioid-substitution-therapy-provision-in-tijuana-mexico
#1
Jose Luis Burgos, Javier A Cepeda, James G Kahn, Maria Luisa Mittal, Emilio Meza, Raúl Rafael Palacios Lazos, Psyché Calderón Vargas, Peter Vickerman, Steffanie A Strathdee, Natasha K Martin
BACKGROUND: Mexico recently enacted drug policy reform to decriminalize possession of small amounts of illicit drugs and mandated that police refer identified substance users to drug treatment. However, the economic implications of drug treatment expansion are uncertain. We estimated the costs of opioid substitution therapy (OST) provision in Tijuana, Mexico, where opioid use and HIV are major public health concerns. METHODS: We adopted an economic health care provider perspective and applied an ingredients-based micro-costing approach to quantify the average monthly cost of OST (methadone maintenance) provision at two providers (one private and one public) in Tijuana, Mexico...
May 23, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29791970/effect-of-high-intensity-resistance-circuit-based-training-in-hypoxia-on-aerobic-performance-and-repeat-sprint-ability
#2
Domingo J Ramos-Campo, Ismael Martínez-Guardado, Guillermo Olcina, Cristian Marín-Pagán, Francisco J Martínez-Noguera, Jorge Carlos-Vivas, Pedro E Alcaraz, Jacobo A Rubio-Arias
Recent acute studies have shown that high-intensity resistance circuit-based (HRC) training in hypoxia increases metabolic stress. However, no intervention studies have yet proven their effectiveness. This study aimed to analyse the effect of 8 weeks of HRC in hypoxia on aerobic performance, resting energy expenditure (REE), repeat sprint ability (RSA) and haematological variables. Twenty-eight subjects were assigned to hypoxia (FiO2 =15%; HRChyp : n=15; age: 24.6±6.8 years; height: 177.4±5.9 cm; weight: 74...
May 23, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29791832/rationale-opportunities-and-reality-of-biosimilar-medications
#3
Gary H Lyman, Robin Zon, R Donald Harvey, Richard L Schilsky
Biologic therapies for cancer and other disorders contribute to improved outcomes for many patients but also account for a large proportion of health care expenditures. Opportunities for cost containment may emerge as the patents on originator products expire and highly similar agents known as..
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791203/short-term-thermoneutral-housing-alters-glucose-metabolism-and-markers-of-adipose-tissue-browning-in-response-to-a-high-fat-diet-in-lean-mice
#4
Zachary Stephen Clayton, Carrie E McCurdy
Systemic insulin resistance and glucose intolerance occur with as little as 3 days of a high-fat diet (HFD) in mice and humans; the mechanisms that initiate acute insulin resistance are unknown. Most laboratories house mice at 22{degree sign}C, which is below their thermoneutral temperature (~30{degree sign}C). Cold stress has been shown to increase white adipose tissue (WAT) browning, alter lipid trafficking and impair immune function, while energy intake and expenditure decrease with increasing ambient temperature; importantly, dysregulation of these parameters have been strongly linked to obesity-induced insulin resistance...
May 23, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29790951/internet-use-and-preventive-health-behaviors-among-couples-in-later-life-evidence-from-the-health-and-retirement-study
#5
Sangbo Nam, Sae Hwang Han, Megan Gilligan
Background and Objectives: The aim of this study was to examine the link between internet use and preventive health behaviors. We focused on couples to examine whether there were cross-partner associations between internet use and preventive health behaviors. Research Design and Methods: The data for this study came from the 2010 and 2012 waves of the Health and Retirement Study and the sample consisted of 5,143 pairs of coupled-individuals. Preventive health behaviors included cancer screenings (mammogram and prostate tests), cholesterol tests, and flu shots...
May 22, 2018: Gerontologist
https://www.readbyqxmd.com/read/29790595/monetary-and-nonmonetary-household-consumption-of-health-services-and-the-role-of-insurance-benefits-an-analysis-of-the-mexico-s-national-household-income-and-expenditure-survey
#6
Edson Serván-Mori, Veronika J Wirtz
OBJECTIVES: To study the monetary and nonmonetary consumption of healthcare services at household level in Mexico and the magnitude of the contribution of public programs. METHODS: By using the National Household Income and Expenditure Survey 2012, we performed a cross-sectional and observational analysis of actual household consumption of health services by insurance type (no insurance, social security, Seguro Popular (SP)). Household consumption was divided into 2 categories: consumption related to "monetary" expenditure in health care and "nonmonetary" consumption in health care by the household...
May 23, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29790444/data-envelopment-analysis-for-estimating-efficiency-of-intensive-care-units-a-case-study-in-iran
#7
Mohammad Amin Bahrami, Sima Rafiei, Mahdieh Abedi, Roohollah Askari
Purpose As hospitals are the most costly service providers in every healthcare systems, special attention should be given to their performance in terms of resource allocation and consumption. The purpose of this paper is to evaluate technical, allocative and economic efficiency in intensive care units (ICUs) of hospitals affiliated by Yazd University of Medical Sciences (YUMS) in 2015. Design/methodology/approach This was a descriptive, analytical study conducted in ICUs of seven training hospitals affiliated by YUMS using data envelopment analysis (DEA) in 2015...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29788789/measuring-functional-impairment-in-children-and-adolescents-psychometric-properties-of-the-columbia-impairment-scale-cis
#8
Brandon K Attell, Christopher Cappelli, Brigitte Manteuffel, Hongli Li
The role of measuring functional impairment holds an important place in research, clinical practice, and service provision for children and adolescents. Responding to the growing need to measure serious emotional disturbances at the local, state, and national level, the Columbia Impairment Scale (CIS) was developed in the early 1990s and has remained one of the several popular scales for assessing functional impairment. However, despite the growing popularity of the instrument in research and practice, only a few studies to date have specifically examined the psychometric properties of the CIS...
January 1, 2018: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/29788444/norepinephrine-and-thyroxine-are-predictors-of-fat-mass-gain-in-humans-with-cold-induced-brown-adipose-tissue-activation
#9
Brittany Begaye, Paolo Piaggi, Marie S Thearle, Kaitlyn Haskie, Mary Walter, Mathias Schlögl, Susan Bonfiglio, Jonathan Krakoff, Karyne L Vinales
Context: In healthy adults with detectable cold-induced brown fat activation (CIBA), the relationships between sympathetic nervous system (SNS) or thyroid activity during energy balance (EBL) with CIBA and body composition change are undetermined. Objective: To investigate the relationships between CIBA and thermoneutral catecholamines and thyroid hormones measured during EBL and to determine if CIBA, catecholamines, or thyroid hormones predict body composition changes...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788288/food-exclusion-based-on-igg-antibodies-alleviates-symptoms-in-ulcerative-colitis-a-prospective-study
#10
Liu Jian, He Anqi, Liu Gang, Wang Litian, Xu Yanyan, Wang Mengdi, Liu Tong
Background: Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods: The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group...
May 16, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788203/do-cost-containment-policies-save-money-and-influence-physicians-prescribing-behavior-lessons-from-south-korea-s-drug-policy-for-diabetes-medication
#11
Shin-On Kang, Seung Ju Kim, Sohee Park, Sung-In Jang, Eun-Cheol Park
Objective: We evaluate the effects of drug price reduction policy on pharmaceutical expenditure and prescription patterns in diabetes medication. Design: An interrupted time series study design using generalized estimating equations. Setting: This study used National Health Insurance claim data from 2010 to 2013. Participants: A total of 68 127 diabetes patients and 12 465 hospitals. Intervention(s): The drug price reduction policy...
May 17, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29788014/persistently-increased-resting-energy-expenditure-predicts-short-term-mortality-in-patients-with-acute-on-chronic-liver-failure
#12
Jia Yao, Xiaoshuang Zhou, Hui Wang, Lili Yuan, Yu Chen, Zhongping Duan
OBJECTIVE: Hypermetabolism based on measurements of resting energy expenditure (REE) is suggested to be a potential biomarker for predicting the clinical outcomes of some diseases. We aimed to evaluate the potential value of hypermetabolism for predicting the short-term (28-day) mortality of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). METHODS: A total of 105 HBV-ACLF patients, 30 chronic hepatitis B (CHB) patients and 30 healthy controls (HCs) were included in this study...
May 22, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29787724/disease-tolerance-linking-sickness-behaviours-to-metabolism-helps-mitigate-malaria
#13
Pedro F Vale
Malaria-infected mice exhibit a range of sickness behaviours, and experience metabolic shifts and physiological pathologies that result in reduced energy expenditure. Treating sick mice with glucose increases disease tolerance by improving the physiological and behavioural symptoms of malaria infection without affecting parasite loads.
May 21, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29787574/child-morbidity-and-mortality-associated-with-alternative-policy-responses-to-the-economic-crisis-in-brazil-a-nationwide-microsimulation-study
#14
Davide Rasella, Sanjay Basu, Thomas Hone, Romulo Paes-Sousa, Carlos Octávio Ocké-Reis, Christopher Millett
BACKGROUND: Since 2015, a major economic crisis in Brazil has led to increasing poverty and the implementation of long-term fiscal austerity measures that will substantially reduce expenditure on social welfare programmes as a percentage of the country's GDP over the next 20 years. The Bolsa Família Programme (BFP)-one of the largest conditional cash transfer programmes in the world-and the nationwide primary healthcare strategy (Estratégia Saúde da Família [ESF]) are affected by fiscal austerity, despite being among the policy interventions with the strongest estimated impact on child mortality in the country...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29787541/validation-of-predictive-equations-to-assess-energy-expenditure-in-acute-spinal-cord-injury
#15
Christine L Ramirez, Stacy Pelekhaty, Jennifer M Massetti, Samuel Galvagno, Laura Harmon, Isadora Botwinick, Thomas M Scalea, Deborah M Stein
BACKGROUND: Acute spinal cord injury (SCI) is devastating with morbidities compounded by inadequate nutrition. The American Society for Parenteral and Enteral Nutrition recommends indirect calorimetry (IC) to evaluate energy needs in SCI because no predictive energy equations have been validated. We sought to determine the accuracy of predictive equations to predict measured energy expenditure (MEE). METHODS: A retrospective review was performed over 2 years. Patients 18 years or older with cervical SCI who received IC were included...
April 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787309/predicting-intensive-care-unit-readmission-with-machine-learning-using-electronic-health-record-data
#16
Juan C Rojas, Kyle A Carey, Dana P Edelson, Laura R Venable, Michael D Howell, Matthew M Churpek
RATIONALE: Patients transferred from the intensive care unit (ICU) to the wards who are later readmitted to the ICU have increased length of stay, healthcare expenditure, and mortality compared to those who are never readmitted. Improving risk-stratification for patients transferred to the wards could have important benefits for critically ill hospitalized patients. OBJECTIVE: We aimed to use a machine-learning technique to derive and validate an ICU readmission prediction model with variables available in the electronic health record (EHR) in real-time and compare it to previously published algorithms...
May 22, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29786816/examination-of-morbidity-and-mortality-of-cases-according-to-intra-vehicle-position-and-accident-mechanism
#17
Orhan Meral, Ekin Özgür Aktaş, Murat Ersel
BACKGROUND: Traffic accidents are still an important public health issue in our country and intra-vehicle accidents cause substantial morbidity and mortality. In this study, we aimed to investigate the effect of seating position on morbidity and mortality in traffic accidents. METHODS: Patients who were admitted to the Emergency Department, Faculty of Medicine, Ege University between May 1, 2014 and November 30, 2014 due to injuries in motor vehicles and who signed informed consent were included...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29785203/conflict-and-tuberculosis-in-sudan-a-10-year-review-of-the-national-tuberculosis-programme-2004-2014
#18
Sara A Hassanain, Jeffrey K Edwards, Emilie Venables, Engy Ali, Khadiga Adam, Hafiz Hussien, Asma Elsony
Background: Sudan is a fragile developing country, with a low expenditure on health. It has been subjected to ongoing conflicts ever since 1956, with the Darfur crisis peaking in 2004. The conflict, in combination with the weak infrastructure, can lead to poor access to healthcare. Hence, this can cause an increased risk of infection, greater morbidity and mortality from tuberculosis (TB), especially amongst the poor, displaced and refugee populations. This study will be the first to describe TB case notifications, characteristics and outcomes over a ten-year period in Darfur in comparison with the non-conflict Eastern zones within Sudan...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29784793/camp-inducible-coactivator-crtc3-attenuates-brown-adipose-tissue-thermogenesis
#19
Young-Sil Yoon, Wen-Wei Tsai, Sam Van de Velde, Zhijiang Chen, Kuo-Fen Lee, Donald A Morgan, Kamal Rahmouni, Shigenobu Matsumura, Ezra Wiater, Youngsup Song, Marc Montminy
In response to cold exposure, placental mammals maintain body temperature by increasing sympathetic nerve activity in brown adipose tissue (BAT). Triggering of β-adrenergic receptors on brown adipocytes stimulates thermogenesis via induction of the cAMP/PKA pathway. Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29783952/differences-between-fast-and-slow-muscles-in-scallops-revealed-through-proteomics-and-transcriptomics
#20
Xiujun Sun, Zhihong Liu, Biao Wu, Liqing Zhou, Qi Wang, Wei Wu, Aiguo Yang
BACKGROUND: Scallops possess striated and catch adductor muscles, which have different structure and contractile properties. The striated muscle contracts very quickly for swimming, whereas the smooth catch muscle can keep the shells closed for long periods with little expenditure of energy. In this study, we performed proteomic and transcriptomic analyses of differences between the striated (fast) and catch (slow) adductor muscles in Yesso scallop Patinopecten yessoensis. RESULTS: Transcriptomic analysis reveals 1316 upregulated and 8239 downregulated genes in slow compared to fast adductor muscle...
May 22, 2018: BMC Genomics
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