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Transfusion medicine

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https://www.readbyqxmd.com/read/29148106/epidemiology-of-donors-and-recipients-lessons-from-the-scandat-database
#1
REVIEW
G Edgren, H Hjalgrim
With the development of several 'vein-to-vein' databases, which capture data on the entire donor-recipient continuum and link this data to health outcomes, there has been an increasing number of studies investigating the health effects of all aspects of the practice of transfusion medicine. The Scandinavian Donations and Transfusions (SCANDAT) database is one of several such databases, which includes all electronically available data on blood donors, donations and transfusions since the late 1960s in Sweden and the early 1980s in Denmark...
November 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29132978/intensive-care-in-severe-malaria-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#2
REVIEW
Dilip R Karnad, Mohd Basri Mat Nor, Guy A Richards, Tim Baker, Pravin Amin
Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Cerebral malaria is common in children in Africa, manifests as coma and seizures, and has a high morbidity and mortality. In other regions, adults may also develop cerebral malaria but neurological sequelae in survivors are rare...
November 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29114436/preferred-names-preferred-pronouns-and-gender-identity-in-the-electronic-medical-record-and-laboratory-information-system-is-pathology-ready
#3
Katherine L Imborek, Nicole L Nisly, Michael J Hesseltine, Jana Grienke, Todd A Zikmund, Nicholas R Dreyer, John L Blau, Maia Hightower, Robert M Humble, Matthew D Krasowski
Background: Electronic medical records (EMRs) and laboratory information systems (LISs) commonly utilize patient identifiers such as legal name, sex, medical record number, and date of birth. There have been recommendations from some EMR working groups (e.g., the World Professional Association for Transgender Health) to include preferred name, pronoun preference, assigned sex at birth, and gender identity in the EMR. These practices are currently uncommon in the United States. There has been little published on the potential impact of these changes on pathology and LISs...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29102834/establishment-of-an-alternative-efficiently-genotyping-strategy-for-human-abo-gene
#4
Enzhu Jiang, Peifu Yu, Siyi Zhang, Chunmei Li, Mei Ding, Baojie Wang, Hao Pang
ABO genotyping is used in several disciplines, including transfusion, transplantation, human evolution, and forensic medicine. Detection of single nucleotide polymorphisms (SNPs) on a locus is a common way to identify different genotypes. In this study we developed a strategy for ABO genotyping, which can rapidly and efficiently detect SNPs. DNA fragments containing 4 SNPs in the ABO gene (c.261delG, c.297A > G, c.1009A > G, and c.1061delC) were amplified using individually and multiplexed polymerase chain reaction (PCR)-based methods and subsequently genotyped by high-resolution melting (HRM) analysis...
November 1, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29097176/how-shall-we-transfuse-hippolyta
#5
Brendan C Graham, Lindsey J Graham, Carl H Rose, Jeffrey L Winters
The US Department of Defense recently made the decision to open direct ground combat roles to women. Blood product transfusion is an essential component of the US Military guidelines for tactical combat casualty care and damage control resuscitation, but blood transfusion carries with it the specific side effect of alloimmunization-a uniquely significant side effect for young women who may desire subsequent pregnancies. Presently to be considered are the changes that may need to be made to blood transfusion in the setting of battlefield medicine to optimally care for combat-injured women, as a majority of the existing data regarding the risks of transfusion in the trauma setting involve predominantly men...
October 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29090267/perioperative-patient-blood-management-programme-multidisciplinary-recommendations-from-the-patient-blood-management-initiative-group
#6
Daniela Filipescu, Răzvan Bănăţeanu, Mircea Beuran, Traean Burcoş, Dan Corneci, Dan Cristian, Mircea Diculescu, Alina Dobrotă, Gabriela Droc, Dănuţ Isacoff, Doina Goşa, Ioana Grinţescu, Anca Lupu, Liliana Mirea, Corina Posea, Oana Stanca, Mihai Ştefan, Dana Tomescu, Cristina Tudor, Daniela Ungureanu, Gabriel Mircescu
Patients with untreated anaemia or iron deficiency who undergo surgical procedures have an increased risk for mortality and morbidity. Patient Blood Management programmes address this issue worldwide and try to improve patient outcomes through a complex set of measures targeting anaemia correction, minimisation of bleeding and improvement of anaemia tolerance, in all phases of perioperative care. The Patient Blood Management Initiative Group is a multidisciplinary team of physicians from specialties including anaesthesiology, nephrology, surgery, orthopaedics, haematology, gastroenterology and transfusion medicine...
October 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/29090212/metabolism-of-citrate-and-other-carboxylic-acids-in-erythrocytes-as-a-function-of-oxygen-saturation-and-refrigerated-storage
#7
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Tatsuro Yoshida, Andrew Dunham, Edward Y Wen, Alexander Q Wen, Rob C Roach, Kirk C Hansen, Yang Xia, Angelo D'Alessandro
State-of-the-art proteomics technologies have recently helped to elucidate the unanticipated complexity of red blood cell metabolism. One recent example is citrate metabolism, which is catalyzed by cytosolic isoforms of Krebs cycle enzymes that are present and active in mature erythrocytes and was determined using quantitative metabolic flux analysis. In previous studies, we reported significant increases in glycolytic fluxes in red blood cells exposed to hypoxia in vitro or in vivo, an observation relevant to transfusion medicine owing to the potential benefits associated with hypoxic storage of packed red blood cells...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29083113/hydroxyethyl-starch-and-kidney-function-a-retrospective-study-in-patients-undergoing-therapeutic-plasma-exchange
#8
Muthuchellappan Radhakrishnan, Akshay Batra, Sundar Periyavan, Mariamma Philip, Vivek Anand
PURPOSE: Hydroxyethyl starch (HES) and albumin are used as replacement fluids during therapeutic plasma exchange (TPE). HES solutions are no longer recommended in critically ill patients due to its effect on kidneys and coagulation. In this retrospective study, we tried to look at the association between cumulative HES administration and kidney function in patients undergoing TPE. METHODS: Transfusion medicine department register was scrutinized to identify adult patients who had completed at least 5 cycles of TPE during the period June 2014-May 2015...
October 30, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29078929/blood-product-transfusions-and-reactions
#9
REVIEW
Jessica L Osterman, Sanjay Arora
Blood product transfusions are an essential component of the practice of emergency medicine. From acute traumatic hemorrhage to chronic blood loss necessitating transfusion for symptomatic anemia, familiarity with individual blood products and their indications for transfusion is an essential tool for every emergency physician (EP). Although the focus of this article is primarily on the transfusion of red blood cells, many of the concepts are applicable to the transfusion of all blood products. EPs must be fully familiar with both the individual blood components and the potential reactions and complications of these transfusions...
December 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29076249/expanding-access-to-transfusion-medicine-and-improving-practice-guidelines-patient-blood-management-protocols-and-products
#10
EDITORIAL
D J Roberts
No abstract text is available yet for this article.
October 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29076098/good-manufacturing-practice-gmp-translation-of-advanced-cellular-therapeutics-lessons-for-the-manufacture-of-erythrocytes-as-medicinal-products
#11
Neil W A McGowan, John D M Campbell, Joanne C Mountford
Blood transfusion is a mainstay of modern medical practice. In many parts of the world the use of this life-saving therapy is hampered by issues of supply and the potential for transfusion transmitted infections. Accordingly, there are many studies seeking to find an alternative to donated red blood cells (RBCs) for transfusion, including large-scale production from adult and pluripotent stem cells, or erythroid cell lines. Translating basic studies, using any cell lineage, into protocols that are suitable for the generation of cellular therapies requires a wide range of biological and regulatory procedures to be put in place...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29071816/application-of-multiplex-ligation-dependent-probe-amplification-assay-for-genotyping-major-blood-group-systems-including-del-variants-in-the-d-negative-korean-population
#12
Banseok Kim, Seung Tae Lee, Sinyoung Kim, Jong Rak Choi, Hyun Ok Kim
BACKGROUND: The DEL blood type, a very weak D variant, is a major concern in the field of transfusion medicine because of its potential to cause anti-D alloimmunization. We investigated the molecular basis of serologically D-negative phenotypes, including the DEL type, and the distribution of other blood group systems in the Korean population using the recently developed multiplex ligation-dependent probe amplification (MLPA) assay. METHODS: Blood group genotyping using the MLPA assay and RhCE phenotyping were performed on randomly selected 95 D-negative red blood cell products...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29070972/congress-of-the-german-society-of-transfusion-medicine-and-immunohematology-50th-anniversary
#13
EDITORIAL
Harald Klüter, Birgit Gathof, Peter Schlenke
No abstract text is available yet for this article.
September 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29070083/human-immunodeficiency-virus-infection-acquired-through-a-traditional-healer-s-ritual-a-case-report
#14
Pedro Pallangyo, Paulina Nicholaus, Henry Mayala, Andrew Kabeho, Anna Nkinda, Mohamed Janabi
BACKGROUND: Globally, over 36 million people were infected with human immunodeficiency virus by the end of 2015. The Sub-Saharan African region home to less than one-fifth of the global population disproportionately harbors over two-thirds of the total infections and related deaths. Residents of Sub-Saharan Africa continue to face limited access to allopathic medicine and it is estimated that over 80% of primary health care needs in the region are met through traditional healing practices...
October 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29067705/demographic-and-epidemiologic-characterization-of-transfusion-recipients-from-four-us-regions-evidence-from-the-reds-iii-recipient-database
#15
Matthew S Karafin, Roberta Bruhn, Matt Westlake, Marian T Sullivan, Walter Bialkowski, Gustaf Edgren, Nareg H Roubinian, Ronald G Hauser, Daryl J Kor, Debra Fleischmann, Jerome L Gottschall, Edward L Murphy, Darrell J Triulzi
BACKGROUND: Blood transfusion is one of the most common medical procedures during hospitalization in the United States. To understand the benefits of transfusion while mitigating potential risks, a multicenter database containing detailed information on transfusion incidence and recipient outcomes would facilitate research. STUDY DESIGN AND METHODS: The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) program has developed a comprehensive transfusion recipient database utilizing data from hospital electronic health records at 12 participating hospitals in four geographic regions...
October 24, 2017: Transfusion
https://www.readbyqxmd.com/read/29064872/no-differences-in-renal-function-between-balanced-6-hydroxyethyl-starch-130-0-4-and-5-albumin-for-volume-replacement-therapy-in-patients-undergoing-cystectomy-a-randomized-controlled-trial
#16
Tobias Kammerer, Florian Brettner, Sebastian Hilferink, Nikolai Hulde, Florian Klug, Judith Pagel, Alexander Karl, Alexander Crispin, Klaus Hofmann-Kiefer, Peter Conzen, Markus Rehm
BACKGROUND: The use of artificial colloids has declined in critical care, whereas they are still used in perioperative medicine. Little is known about the nephrotoxic potential in noncritically ill patients during routine surgery. The objective of this trial was to evaluate the influences of albumin 5% and balanced hydroxyethyl starch 6% (130/0.4) on renal function and kidney injury. METHODS: One-hundred urologic patients undergoing elective cystectomy were randomly assigned for this prospective, single-blinded, controlled study with two parallel groups to receive either albumin 5% or balanced hydroxyethyl starch 6% (130/0...
October 24, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29061498/effect-of-a-red-blood-cell-transfusion-on-biological-markers-used-to-determine-the-cause-of-anemia-a-prospective-study
#17
Antoine Froissart, Benjamin Rossi, Brigitte Ranque, Irène Jarrin, Jean-François Bergmann, Sébastien Beaune, Sandrine Dautheville, Nicole Breau, Agnès Dauvergne, Lauréline Deluche, Tiphaine Robert, Nathalie Gault, Carine Roy, Virginie Zarrouk, Olivier Steichen, Bruno Fantin
BACKGROUND: Blood test results required for the evaluation of anemia are considered difficult to interpret after red blood cell transfusion. However, this hypothesis is neither supported by a strong physiological rationale nor is it evidence based. METHODS: We conducted a prospective multicenter study to compare the values of key assays before and after a course of red blood cell transfusion in the emergency or internal medicine units in four university hospitals...
October 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29058354/the-practice-of-diagnosing-and-reporting-transfusion-associated-circulatory-overload-a-national-survey-among-physicians-and-haemovigilance-officers
#18
J J Bosboom, R B Klanderman, A L Peters, E K van de Weerdt, E J Goudswaard, J M Binnekade, J J Zwaginga, E A M Beckers, B F Geerts, M W Hollmann, S S Zeerleder, M van Kraaij, A P Vlaar
OBJECTIVES: This study aims at identifying factors that disciplines consider when diagnosing and reporting transfusion-associated circulatory overload ('TACO'). BACKGROUND: TACO is a clinical diagnosis based mainly on subjective factors. Therefore, TACO could be an underreported complication of blood transfusion. METHODS: A survey was conducted among critical care physicians, anaesthesiologists, haematologists, transfusion medicine physicians and haemovigilance officers using case vignettes and a questionnaire...
October 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29051799/red-cell-genotyping-precision-medicine-a-conference-summary
#19
REVIEW
Gregory A Denomme, Waseem Q Anani, Neil D Avent, Gregor Bein, Lynne B Briggs, Razvan C Lapadat, Celina Montemayor, Maria Rios, Maryse St-Louis, Lynne Uhl, Silvano Wendel, Willy A Flegel
This review summarizes the salient points of the symposium 'Red Cell Genotyping 2015: Precision Medicine' held on 10 September 2015 in the Masur Auditorium of the National Institutes of Health. The specific aims of this 6th annual symposium were to: (1) discuss how advances in molecular immunohematology are changing patient care; (2) exemplify patient care strategies by case reports (clinical vignettes); (3) review the basic molecular studies and their current implications in clinical practice; (4) identify red cell genotyping strategies to prevent alloimmunization; and (5) compare and contrast future options of red cell genotyping in precision transfusion medicine...
October 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/29050669/-transfusion-clinique-et-biologique-%C3%A2-what-makes-transfusion-medicine-and-biology-so-special
#20
EDITORIAL
O Garraud
No abstract text is available yet for this article.
November 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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