keyword
https://read.qxmd.com/read/38529471/gallbladder-microbial-species-and-host-bile-acids-biosynthesis-linked-to-cholesterol-gallstone-comparing-to-pigment-individuals
#21
JOURNAL ARTICLE
Xinpeng Zhang, Junqing Hu, Yi Li, Jichao Tang, Kaijin Yang, Ayan Zhong, Yanjun Liu, Tongtong Zhang
Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment, or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microbial species spectra of 29 subjects with gallstone disease (GSD, 24 cholesterol and 5 pigment) were revealed by type IIB restriction site-associated DNA microbiome sequencing (2bRAD-M). Among them (21 subjects: 18 cholesterol and 3 pigment), plasma samples were subjected to liquid chromatography-mass spectrometry (LC-MS) untargeted metabolomics...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38529070/retrospective-subgroup-analysis-of-fecal-microbiota-live-jslm-rebyota-%C3%A2-administered-by-colonoscopy-under-enforcement-discretion-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#22
JOURNAL ARTICLE
Whitfield L Knapple, David S Yoho, Alexander Sheh, Joan Thul, Paul Feuerstadt
BACKGROUND: Fecal microbiota, live-jslm (RBL; REBYOTA® ), is the first Food and Drug Administration (FDA)-approved, single-dose, rectally administered, microbiota-based live biotherapeutic product for preventing Clostridioides difficile infection (CDI) recurrence. Alternative routes of administration are of clinical interest. OBJECTIVES: Evaluate the safety and efficacy of RBL administration via colonoscopy. DESIGN: Retrospective analysis of electronic medical records of participants administered RBL via colonoscopy under FDA enforcement discretion...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38528857/an-overview-of-the-bacterial-microbiome-of-public-transportation-systems-risks-detection-and-countermeasures
#23
REVIEW
Yen-Tran Ly, Stefan Leuko, Ralf Moeller
When we humans travel, our microorganisms come along. These can be harmless but also pathogenic, and are spread by touching surfaces or breathing aerosols in the passenger cabins. As the pandemic with SARS-CoV-2 has shown, those environments display a risk for infection transmission. For a risk reduction, countermeasures such as wearing face masks and distancing were applied in many places, yet had a significant social impact. Nevertheless, the next pandemic will come and additional countermeasures that contribute to the risk reduction are needed to keep commuters safe and reduce the spread of microorganisms and pathogens, but also have as little impact as possible on the daily lives of commuters...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38527613/gut-microbiome-diversity-and-composition-in-individuals-with-and-without-extended-spectrum-%C3%AE-lactamase-producing-enterobacterales-carriage-a-matched-case-control-study-in-infectious-diseases-department
#24
JOURNAL ARTICLE
Anders Boyd, Mariam El Dani, Roula Ajrouche, Vanessa Demontant, Justine Cheval, Karine Lacombe, Guillaume Cosson, Christophe Rodriguez, Jean-Michel Pawlotsky, Paul-Louis Woerther, Laure Surgers
OBJECTIVE: Little is known on the effect of gut microbial and Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) carriage, particularly in the general population. The aim of this study was to identify microbiota signatures uniquely correlated with ESBL-E carriage. METHODS: We conducted a case-control study among individuals seeking care at the Sexual Health Clinic or Department of Infectious and Tropical Diseases at Saint-Antoine Hospital, Paris, France...
March 23, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38525219/probiotic-supplementation-as-an-alternative-to-antibiotics-in-broiler-chickens
#25
JOURNAL ARTICLE
Grzegorz Tomczyk, Jowita Samanta Niczyporuk, Wojciech Kozdruń, Anna Sawicka-Durkalec, Łukasz Bocian, Marcin Barabasz, Marcin Michalski
INTRODUCTION: The broiler chicken digestive tract microbiome maintains the bird's immunity. Its composition has been shown to be important not only for the immune system but also for the gastrointestinal function and productivity of broiler chickens. If the microbiome is populated by supplementation with Lactobacillus, Pediococcus and Saccharomyces spp. - microorganisms with probiotic properties and alternatives to antibiotics - the immune system is stimulated. The use of probiotic supplements in the broiler production cycle can boost bird immunity and prevent adenovirus infection...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38524669/gut-microbiome-dynamics-and-enterobacterales-infection-in-liver-transplant-recipients-a-prospective-observational-study
#26
JOURNAL ARTICLE
Federica D'Amico, Matteo Rinaldi, Renato Pascale, Marco Fabbrini, Maria Cristina Morelli, Antonio Siniscalchi, Cristiana Laici, Simona Coladonato, Matteo Ravaioli, Matteo Cescon, Simone Ambretti, Pierluigi Viale, Patrizia Brigidi, Silvia Turroni, Maddalena Giannella
BACKGROUND & AIMS: The aim of this study was to investigate gut microbiome (GM) dynamics in relation to carbapenem-resistant Enterobacterales (CRE) colonization, CRE infection, and non-CRE infection development within 2 months after liver transplant (LT). METHODS: A single-center, prospective study was performed in patients undergoing LT from November 2018 to January 2020. The GM was profiled through 16S rRNA amplicon sequencing of a rectal swab taken on the day of transplantation, and fecal samples were collected weekly until 1 month after LT...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38523602/myd88-exacerbates-inflammation-induced-bone-loss-by-modulating-dynamic-equilibrium-between-th17-treg-cells-and-subgingival-microbiota-dysbiosis
#27
JOURNAL ARTICLE
Po-Yan Hsiao, Ren-Yeong Huang, Lin-Wei Huang, Ching-Liang Chu, Thomas Van Dyke, Lian-Ping Mau, Chia-Dan Cheng, Cheng-En Sung, Pei-Wei Weng, Yu-Chiao Wu, Yi-Shing Shieh, Wan-Chien Cheng
BACKGROUND: This study aimed to investigate the contribution of myeloid differentiation primary-response gene 88 (MyD88) on the differentiation of T helper type 17 (Th17) and regulatory T (Treg) cells and the emerging subgingival microbiota dysbiosis in Porphyromonas gingivalis-induced experimental periodontitis. METHODS: Alveolar bone loss, infiltrated inflammatory cells, immunostained cells for tartrate-resistant acid phosphatase (TRAP), the receptor activator of nuclear factor-kB ligand (RANKL), and osteoprotegerin (OPG) were quantified by microcomputerized tomography and histological staining between age- and sex-matched homozygous littermates (wild-type [WT, Myd88+/+ ] and Myd88-/- on C57BL/6 background)...
March 25, 2024: Journal of Periodontology
https://read.qxmd.com/read/38523273/ecological-patterns-and-processes-of-temporal-turnover-within-lung-infection-microbiota
#28
JOURNAL ARTICLE
Helen Gavillet, Lauren Hatfield, Andrew Jones, Anirban Maitra, Alexander Horsley, Damian Rivett, Christopher van der Gast
BACKGROUND: Chronic infection and consequent airway inflammation are the leading causes of morbidity and early mortality for people living with cystic fibrosis (CF). However, lower airway infections across a range of chronic respiratory diseases, including in CF, do not follow classical 'one microbe, one disease' concepts of infection pathogenesis. Instead, they are comprised of diverse and temporally dynamic lung infection microbiota. Consequently, temporal dynamics need to be considered when attempting to associate lung microbiota with changes in disease status...
March 25, 2024: Microbiome
https://read.qxmd.com/read/38522483/microbiome-interactions-with-different-risk-factors-in-development-of-myocardial-infarction
#29
REVIEW
Manisha Bijla, Sunil Kumar Saini, Ajai Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites...
March 22, 2024: Experimental Gerontology
https://read.qxmd.com/read/38521963/genomic-functional-and-metabolic-enhancements-in-multidrug-resistant-enterobacter%C3%A2-bugandensis%C3%A2-facilitating-its-persistence-and-succession-in-the-international-space-station
#30
JOURNAL ARTICLE
Pratyay Sengupta, Shobhan Karthick Muthamilselvi Sivabalan, Nitin Kumar Singh, Karthik Raman, Kasthuri Venkateswaran
BACKGROUND: The International Space Station (ISS) stands as a testament to human achievement in space exploration. Despite its highly controlled environment, characterised by microgravity, increased CO <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msub><mml:mrow/> <mml:mn>2</mml:mn></mml:msub> </mml:math> levels, and elevated solar radiation, microorganisms occupy a unique niche. These microbial inhabitants play a significant role in influencing the health and well-being of astronauts on board...
March 23, 2024: Microbiome
https://read.qxmd.com/read/38521952/enhanced-bacterial-cancer-therapy-delivering-therapeutic-rna-interference-of-c-myc
#31
JOURNAL ARTICLE
Jason S Williams, Adam T Higgins, Katie J Stott, Carly Thomas, Lydia Farrell, Cleo S Bonnet, Severina Peneva, Anna V Derrick, Trevor Hay, Tianqi Wang, Claire Morgan, Sarah Dwyer, Joshua D'Ambrogio, Catherine Hogan, Matthew J Smalley, Lee Parry, Paul Dyson
BACKGROUND: Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid instability. To overcome this, we sought to develop tumour-targeting attenuated bacteria that stably express shRNA by virtue of integration of an expression cassette within the bacterial chromosome and demonstrate therapeutic efficacy in vitro and in vivo...
March 23, 2024: Cell & Bioscience
https://read.qxmd.com/read/38521228/hungatella-hathewayi-bacteremia-due-to-acute-appendicitis-a-case-report-and-a-narrative-review
#32
Elie Bou Sanayeh, Mark Tawfik, Marina Makram, Georges Khattar, Faris Qaqish, Sudeep Acharya, Janet Farag, Michel Chalhoub, Allison Glaser
Hungatella species, including Hungatella hathewayi and Hungatella effluvii, previously identified as part of the Clostridium genus, are anaerobic bacteria primarily residing in the gut microbiome, with infrequent implications in human infections. This article presents the case of an 87-year-old Asian male admitted for a hyperosmolar hyperglycemic state with septic shock secondary to Hungatella hathewayi bacteremia originating from acute appendicitis. Remarkably, the bacterium was detected in the blood 48 hours before the emergence of clinical and radiographic evidence of acute appendicitis...
March 21, 2024: Anaerobe
https://read.qxmd.com/read/38520837/airway-commensal-bacteria-in-cystic-fibrosis-inhibit-the-growth-of-p-aeruginosa-via-a-released-metabolite
#33
JOURNAL ARTICLE
Andrew Tony-Odigie, Alexander H Dalpke, Sébastien Boutin, Buqing Yi
In cystic fibrosis (CF), Pseudomonas aeruginosa infection plays a critical role in disease progression. Although multiple studies suggest that airway commensals might be able to interfere with pathogenic bacteria, the role of the distinct commensals in the polymicrobial lung infections is largely unknown. In this study, we aimed to identify airway commensal bacteria that may inhibit the growth of P. aeruginosa. Through a screening study with more than 80 CF commensal strains across 21 species, more than 30 commensal strains from various species have been identified to be able to inhibit the growth of P...
March 9, 2024: Microbiological Research
https://read.qxmd.com/read/38520075/signals-that-control-mait-cell-function-in-healthy-and-inflamed-human-tissues
#34
REVIEW
Andrew J Konecny, Yin Huang, Manu Setty, Martin Prlic
Mucosal-associated invariant T (MAIT) cells have a semi-invariant T-cell receptor that allows recognition of antigen in the context of the MHC class I-related (MR1) protein. Metabolic intermediates of the riboflavin synthesis pathway have been identified as MR1-restricted antigens with agonist properties. As riboflavin synthesis occurs in many bacterial species, but not human cells, it has been proposed that the main purpose of MAIT cells is antibacterial surveillance and protection. The majority of human MAIT cells secrete interferon-gamma (IFNg) upon activation, while some MAIT cells in tissues can also express IL-17...
March 22, 2024: Immunological Reviews
https://read.qxmd.com/read/38519882/hpv-associated-cervicovaginal-microbiome-and-host-metabolome-characteristics
#35
JOURNAL ARTICLE
Yao Zhang, Xu Wu, Dan Li, Rong Huang, Xiangyu Deng, Mingxing Li, Fukuan Du, Yueshui Zhao, Jing Shen, Yu Chen, Pingxiu Zhang, Congcui Hu, Zhangang Xiao, Qinglian Wen
BACKGROUND: Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively...
March 22, 2024: BMC Microbiology
https://read.qxmd.com/read/38519354/datathons-fostering-equitability-in-data-reuse-in-ecology
#36
JOURNAL ARTICLE
Stephanie D Jurburg, María J Álvarez Blanco, Antonis Chatzinotas, Anahita Kazem, Birgitta König-Ries, Doreen Babin, Kornelia Smalla, Victoria Cerecetto, Gabriela Fernandez-Gnecco, Fernanda Covacevich, Emilce Viruel, Yesica Bernaschina, Carolina Leoni, Silvia Garaycochea, Jose A Terra, Pablo Fresia, Eva Lucía Margarita Figuerola, Luis Gabriel Wall, Julieta Mariana Covelli, Ana Carolina Agnello, Esteban Emanuel Nieto, Sabrina Festa, Lina Edith Dominici, Marco Allegrini, María Celina Zabaloy, Marianela Estefanía Morales, Leonardo Erijman, Anahi Coniglio, Fabricio Dario Cassán, Sofia Nievas, Diego M Roldán, Rodolfo Menes, Patricia Vaz Jauri, Carla Silva Marrero, Adriana Montañez Massa, María Adelina Morel Revetria, Ana Fernández-Scavino, Luciana Pereira-Mora, Soledad Martínez, Juan Pablo Frene
Approaches to rapidly collecting global biodiversity data are increasingly important, but biodiversity blind spots persist. We organized a three-day Datathon event to improve the openness of local biodiversity data and facilitate data reuse by local researchers. The first Datathon, organized among microbial ecologists in Uruguay and Argentina assembled the largest microbiome dataset in the region to date and formed collaborative consortia for microbiome data synthesis.
March 21, 2024: Trends in Microbiology
https://read.qxmd.com/read/38518435/standards-for-fecal-microbiota-transplant-tools-and-therapeutic-advances
#37
JOURNAL ARTICLE
Ilia Belotserkovsky, Lisa M Stabryla, Monique Hunter, Jessica Allegretti, Benjamin J Callahan, Paul E Carlson, Phillip J Daschner, Maryam Goudarzi, Cyril Guyard, Scott A Jackson, Krishna Rao, Stephanie L Servetas, Harry Sokol, Jennifer A Wargo, Shawn Novick
Fecal microbiota transplantation (FMT) has been demonstrated to be efficacious in preventing recurrent Clostridioides difficile (C. difficile) infections, and is being investigated for treatment of several other diseases including inflammatory bowel disease, cancer, obesity, liver disease, and diabetes. To speed up the translation of FMT into clinical practice as a safe and standardized therapeutic intervention, additional evidence-based technical and regulatory guidance is needed. To this end in May of 2022, the International Alliance for Biological Standardization (IABS) and the BIOASTER Microbiology Technology Institute hosted a second webinar to discuss key issues still impeding the advancement and standardization of FMT...
March 21, 2024: Biologicals: Journal of the International Association of Biological Standardization
https://read.qxmd.com/read/38515324/microbiomes-detected-by-cerebrospinal-fluid-metagenomic-next-generation-sequencing-among-patients-with-and-without-hiv-with-suspected-central-nervous-system-infection
#38
JOURNAL ARTICLE
Shi Zou, Zhong Chen, Yuting Tan, Miao Tan, Wei Guo, Songjie Wu, Jie Liu, Shihui Song, Yongquan Peng, Min Wang, Ke Liang
BACKGROUND: Opportunistic infections in the central nervous system (CNS) can be a serious threat to people living with HIV. Early aetiological diagnosis and targeted treatment are crucial but difficult. Metagenomic next-generation sequencing (mNGS) has significant advantages over traditional detection methods. However, differences in the cerebrospinal fluid (CSF) microbiome profiles of patients living with and without HIV with suspected CNS infections using mNGS and conventional testing methods have not yet been adequately evaluated...
March 21, 2024: HIV Medicine
https://read.qxmd.com/read/38514648/integrative-metagenomic-and-metabolomic-analyses-reveal-the-potential-of-gut-microbiota-to-exacerbate-acute-pancreatitis
#39
JOURNAL ARTICLE
Jianjun Liu, Qiulong Yan, Shenghui Li, Juying Jiao, Yiming Hao, Guixin Zhang, Qingkai Zhang, Fei Luo, Yue Zhang, Qingbo Lv, Wenzhe Zhang, Aiqin Zhang, Huiyi Song, Yi Xin, Yufang Ma, Lawrence Owusu, Xiaochi Ma, Peiyuan Yin, Dong Shang
Early dysbiosis in the gut microbiota may contribute to the severity of acute pancreatitis (AP), however, a comprehensive understanding of the gut microbiome, potential pathobionts, and host metabolome in individuals with AP remains elusive. Hence, we employed fecal whole-metagenome shotgun sequencing in 82 AP patients and 115 matched healthy controls, complemented by untargeted serum metabolome and lipidome profiling in a subset of participants. Analyses of the gut microbiome in AP patients revealed reduced diversity, disrupted microbial functions, and altered abundance of 77 species, influenced by both etiology and severity...
March 21, 2024: NPJ Biofilms and Microbiomes
https://read.qxmd.com/read/38514634/promastigote-eps-secretion-and-haptomonad-biofilm-formation-as-evolutionary-adaptations-of-trypanosomatid-parasites-for-colonizing-honeybee-hosts
#40
JOURNAL ARTICLE
Jéssica Carreira de Paula, Pedro García Olmedo, Tamara Gómez-Moracho, María Buendía-Abad, Mariano Higes, Raquel Martín-Hernández, Antonio Osuna, Luis Miguel de Pablos
Bees are major pollinators involved in the maintenance of all terrestrial ecosystems. Biotic and abiotic factors placing these insects at risk is a research priority for ecological and agricultural sustainability. Parasites are one of the key players of this global decline and the study of their mechanisms of action is essential to control honeybee colony losses. Trypanosomatid parasites and particularly the Lotmaria passim are widely spread in honeybees, however their lifestyle is poorly understood. In this work, we show how these parasites are able to differentiate into a new parasitic lifestyle: the trypanosomatid biofilms...
March 21, 2024: NPJ Biofilms and Microbiomes
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