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Microbiome vascular catheters

Christos Rammos, Ulrike B Hendgen-Cotta, Matthias Totzeck, Julia Pohl, Peter Lüdike, Ulrich Flögel, René Deenen, Karl Köhrer, Brent A French, Axel Gödecke, Malte Kelm, Tienush Rassaf
AIMS: Diastolic dysfunction is highly prevalent, and ageing is the main contributor due to impairments in active cardiac relaxation, ventriculo-vascular stiffening, and endothelial dysfunction. Nitric oxide (NO) affects cardiovascular functions, and NO bioavailability is critically reduced with ageing. Whether replenishment of NO deficiency with dietary inorganic nitrate would offer a novel approach to reverse age-related cardiovascular alterations was not known. METHODS AND RESULTS: A dietary nitrate supplementation was applied to young (6 month) and old (20 month) wild-type mice for 8 weeks and compared with controls...
June 2016: European Journal of Heart Failure
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