Andres R Henriquez, Samantha J Snow, Thomas W Jackson, John S House, Devin I Alewel, Mette C Schladweiler, Matthew C Valdez, Danielle L Freeborn, Colette N Miller, Rachel Grindstaff, Prasada Rao S Kodavanti, Urmila P Kodavanti
Psychosocially-stressed individuals might have exacerbated responses to air pollution exposure. Acute ozone exposure activates the neuroendocrine stress response leading to systemic metabolic and lung inflammatory changes. We hypothesized chronic mild stress (CS) and/or social isolation (SI) would cause neuroendocrine, inflammatory, and metabolic phenotypes that would be exacerbated by an acute ozone exposure. Male 5-week-old Wistar-Kyoto rats were randomly assigned into 3 groups: no stress (NS) (pair-housed, regular-handling); SI (single-housed, minimal-handling); CS (single-housed, subjected to mild unpredicted-randomized stressors [restraint-1 h, tilted cage-1 h, shaking-1 h, intermittent noise-6 h, and predator odor-1 h], 1-stressor/day*5-days/week*8-weeks...
October 29, 2022: Toxicology and Applied Pharmacology