keyword
MENU ▼
Read by QxMD icon Read
search

Neutrophils and catecholamines

keyword
https://www.readbyqxmd.com/read/28884416/repeated-stress-exaggerates-lipopolysaccharide-induced-inflammatory-response-in-the-rat-spleen
#1
M Laukova, Peter Vargovic, I Rokytova, G Manz, R Kvetnansky
Spleen is an immune organ innervated with sympathetic nerves which together with adrenomedullary system control splenic immune functions. However, the mechanism by which prior stress exposure modulates the immune response induced by immunogenic challenge is not sufficiently clarified. Thus, the aim of this study was to investigate the effect of a single (2 h) and repeated (2 h daily for 7 days) immobilization stress (IMO) on the innate immune response in the spleen induced by lipopolysaccharide (LPS, 100 µg/kg)...
September 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28732504/ischaemic-stroke-and-the-recanalization-drug-tissue-plasminogen-activator-interfere-with-antibacterial-phagocyte-function
#2
Antje Vogelgesang, Claudia Lange, Lara Blümke, Georg Laage, Sarah Rümpel, Sönke Langner, Barbara M Bröker, Alexander Dressel, Johanna Ruhnau
BACKGROUND: Stroke induces immune alterations such as impaired oxidative burst and reduced release of neutrophil extracellular traps (NETs). We hypothesised that key enzymes of these defence mechanisms may be altered in ischaemic stroke. Therefore, we analysed the intra- and extracellular amounts of myeloperoxidase (MPO) and neutrophil elastase (NE) in patient sera and granulocytes and monocytes. Because the autonomous nervous system is thought to mediate stroke-induced immune alterations, we also studied the influence of stress hormones and acetylcholine on MPO and NE...
July 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28614141/role-of-hemorrhagic-shock-in-experimental-polytrauma
#3
Stephanie Denk, Sebastian Weckbach, Philipp Eisele, Christian K Braun, Rebecca Wiegner, Julia J Ohmann, Lisa Wrba, Felix M Hoenes, Philipp Kellermann, Peter Radermacher, Ulrich Wachter, Sebastian Hafner, Oscar McCook, Anke Schultze, Annette Palmer, Sonja Braumüller, Florian Gebhard, Markus Huber-Lang
Hemorrhagic shock (HS) after tissue trauma increases the complication and mortality rate of polytrauma (PT) patients. Although several murine trauma models have been introduced, there is a lack of knowledge about the exact impact of an additional HS. We hypothesized that HS significantly contributes to organ injury, which can be reliably monitored by detection of specific organ damage markers.Therefore we established a novel clinically relevant PT plus HS model in C57BL/6 mice which were randomly assigned to control, HS, PT or PT+HS procedure (n = 8 per group)...
June 13, 2017: Shock
https://www.readbyqxmd.com/read/28475489/differential-modulation-of-innate-immune-response-by-epinephrine-and-estradiol
#4
Sona Margaryan, Armenuhi Hyusyan, Anush Martirosyan, Shushan Sargsian, Gayane Manukyan
Background Although it is widely accepted that catecholamines and estrogens influence immunity and have consequences for health, their effect on innate immunity (e.g. monocytes and neutrophils) is still not fully investigated. Materials and methods Our study aimed to analyze the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, monocyte chemoattractant protein (MCP)-1 and IL-8 by whole blood cells following short-term exposure to epinephrine (Epi) and 17β-estradiol (E2) in the presence or absence of lipopolysaccharide (LPS)...
May 5, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27884589/cohabitation-with-an-ehrlich-tumor-bearing-cagemate-induces-immune-but-not-behavioral-changes-in-male-mice
#5
Thalita R M Machado, Glaucie J Alves, Wanderley M Quinteiro-Filho, João Palermo-Neto
Cohabitation with Ehrlich ascitic tumor-injected conspecifics induces behavioral, neurochemical, endocrine and immune changes indicative of stress and immune impairment in female mice. The present work analyzed the effects of similar cohabitation in Swiss and Balb/C male mice. At least 12 pairs of male mice were divided into a control group and an experimental group. On experimental day 1 (ED1), one animal within each experimental pair was inoculated with 5×10(6) Ehrlich tumor cells intraperitoneally (i.p...
February 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27667751/reactive-oxygen-species-mediated-cardiac-reperfusion-injury-mechanisms-and-therapies
#6
REVIEW
Fereshte Bagheri, Vahid Khori, Ali Mohammad Alizadeh, Solmaz Khalighfard, Saeed Khodayari, Hamid Khodayari
Reperfusion injury is an inherent response to the restoration of blood flow after ischemia. It is a complex process involving numerous mechanisms occurring in the intracellular and extracellular environments, and it is mediated in part by reactive oxygen species (ROS). The imbalance between the cellular formation of free radicals and cells' capacity to defend against them can cause cardiac tissue injuries. In this context, ROS play an essential role in both the organ injury and repair processes. After reperfusion, infiltration into the myocardium of inflammatory leucocytes, such as macrophages and neutrophils, causes further ROS production beyond the initiation of the inflammatory cascade...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27520090/white-blood-cell-concentrations-during-lower-body-negative-pressure-and-blood-loss-in-humans
#7
Noud van Helmond, Blair D Johnson, Timothy B Curry, Andrew P Cap, Victor A Convertino, Michael J Joyner
What is the central question of this study? Is lower body negative pressure a useful surrogate to study white blood cell responses to haemorrhage in humans? What is the main finding and its importance? We found that lower body negative pressure appears to be a useful surrogate to study the early white blood cell mobilization response during blood loss. Hypovolaemia has been associated with an immune response that might be secondary to sympathoexcitation. We tested the hypothesis that simulated hypovolaemia using lower body negative pressure (LBNP) and real hypovolaemia induced via experimental blood loss (BL) cause similar increases in the white blood cell concentration ([WBC])...
October 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27133786/psychological-stress-promotes-neutrophil-infiltration-in-colon-tissue-through-adrenergic-signaling-in-dss-induced-colitis-model
#8
Que Deng, Hongyu Chen, Yanjun Liu, Fengjun Xiao, Liang Guo, Dan Liu, Xiang Cheng, Min Zhao, Xiaomeng Wang, Shuai Xie, Siyong Qi, Zhaoyang Yin, Jiangping Gao, Xintian Chen, Jiangong Wang, Ning Guo, Yuanfang Ma, Ming Shi
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition. Psychological stress has been postulated to affect the clinical symptoms and recurrence of IBD. The exact molecular mechanisms are not fully understood. In the present study, we demonstrate that psychological stress promotes neutrophil infiltration into colon tissues in dextran sulfate sodium (DSS)-induced colitis model. The psychological stress resulted in abnormal expression of the proinflammatory cytokines (IL-1β, IL-6, IL-17A, and IL-22) and neutrophil chemokines (CXCL1 and CXCL2) and overactivation of the STAT3 inflammatory signaling pathway...
October 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27106212/spinal-gaba-b-receptor-modulates-neutrophil-recruitment-to-the-knee-joint-in-zymosan-induced-arthritis
#9
Gabriel S Bassi, David do C Malvar, Thiago M Cunha, Fernando Q Cunha, Alexandre Kanashiro
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in a murine model of zymosan-induced arthritis by using different pharmacological tools. We observed that intrathecal administration of baclofen, a selective GABA-B agonist, exacerbated the inflammatory response in the knee after zymosan administration characterized by an increase in the neutrophil recruitment and knee joint edema, whereas saclofen, a GABA-B antagonist, exerted the opposite effect...
August 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27068752/enhanced-activity-of-hormone-sensitive-lipase-hsl-in-mesenteric-but-not-epididymal-fat-correlates-with-higher-production-of-epinephrine-in-mesenteric-adipocytes-in-rat-model-of-cachectic-rheumatoid-arthritis
#10
Andrea Stofkova, Katarina Krskova, Simon Vaculin, Jana Jurcovicova
Cachectic rheumatoid arthritis, the less frequent form of the disease, is associated with loss of fat mass and often more severe course of the disease. Its experimental model represents rat adjuvant arthritis (AA) characterized by edema, lack of appetite, sharp body weight and fat loss. As individual fat depots display functional differences, here we studied lipolytic activity and sensitivity to lipolytic stimuli of nodeless epididymal fat (eWAT) and perinodal mesenteric fat (mWAT) depots at the peak of AA...
June 2016: Autoimmunity
https://www.readbyqxmd.com/read/26764148/ventricular-myocarditis-coincides-with-atrial-myocarditis-in-patients
#11
Mark P V Begieneman, Reindert W Emmens, Liza Rijvers, Bela Kubat, Walter J Paulus, Alexander B A Vonk, Lawrence Rozendaal, P Stefan Biesbroek, Diana Wouters, Sacha Zeerleder, Marieke van Ham, Stephane Heymans, Albert C van Rossum, Hans W M Niessen, Paul A J Krijnen
INTRODUCTION: Atrial fibrillation (AF) is a common complication in myocarditis. Atrial inflammation has been suggested to play an important role in the pathophysiology of AF. However, little is known about the occurrence of atrial inflammation in myocarditis patients. Here, we analyzed inflammatory cell numbers in the atria of myocarditis patients without symptomatic AF. METHODS: Cardiac tissue was obtained postmortem from lymphocytic myocarditis patients (n=6), catecholamine-induced myocarditis patients (n=5), and control patients without pathological evidence of heart disease (n=5)...
March 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/26716738/-the-history-of-renalase-from-amine-oxidase-to-a-a-nad-p-h-oxidase-anomerase
#12
REVIEW
I S Severina, V I Fedchenko, A V Veselovsky, A E Medvedev
Renalase is a recently discovered secretory protein, which plays a certain (still poorly understood) role in regulation of blood pressure. The review summarizes own and literature data accumulated since the first publication on relanase (2005). Initial reports on FAD-dependent amine oxidase activity of this protein were not confirmed in independent experiments performed in different laboratories. In addition, proposed amine oxidase activity of circulating extracellular renalase requires the presence of FAD, which has not been detected either in blood or urinary renalase...
November 2015: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/26628215/periparturient-stress-and-immune-suppression-as-a-potential-cause-of-retained-placenta-in-highly-productive-dairy-cows-examples-of-prevention
#13
REVIEW
Ryszard Mordak, Peter Anthony Stewart, Stewart Peter Anthony
The immune system during the periparturient period is impaired. At this time the most important factor causing immune-suppression in highly productive cows is metabolic stress resulting from hormonal and metabolic fluctuations, a negative energy balance, shortage of proteins, minerals and vitamins which are required to meet the demands of the fetus as well as the onset of lactation. This stress can activate the hypothalamic-pituitary-adrenocortical axis (HPA), which results in increase plasma corticosteroids...
December 2, 2015: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/26541702/psychological-stress-induced-catecholamines-accelerates-cutaneous-aging-in-mice
#14
Bruna Romana-Souza, Gracineide Santos Lima-Cezar, Andréa Monte-Alto-Costa
Psychological stress may be an important extrinsic factor which influences aging process. However, neither study demonstrated the mechanism by which chronic stress participates in skin aging. Aim of this study was to investigate the effects of chronic psychological stress on mice skin. Mice were daily submitted to rotational stress, for 28 days, until euthanasia. After 28 days, mice were killed and normal skin was analyzed. Macroscopically, dorsum skin of chronically stressed mice presented more wrinkled when compared to that of nonstressed mice...
December 2015: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/25678697/functional-changes-in-neutrophils-and-psychoneuroendocrine-responses-during-105-days-of-confinement
#15
C Strewe, F Muckenthaler, M Feuerecker, B Yi, M Rykova, I Kaufmann, I Nichiporuk, G Vassilieva, M Hörl, S Matzel, G Schelling, M Thiel, B Morukov, A Choukèr
The innate immune system as one key element of immunity and a prerequisite for an adequate host defense is of emerging interest in space research to ensure crew health and thus mission success. In ground-based studies, spaceflight-associated specifics such as confinement caused altered immune functions paralleled by changes in stress hormone levels. In this study, six men were confined for 105 days to a space module of ~500 m(3) mimicking conditions of a long-term space mission. Psychic stress was surveyed by different questionnaires...
May 1, 2015: Journal of Applied Physiology
https://www.readbyqxmd.com/read/25624468/functional-capacities-of-human-igm-memory-b-cells-in-early-inflammatory-responses-and-secondary-germinal-center-reactions
#16
Marc Seifert, Martina Przekopowitz, Sarah Taudien, Anna Lollies, Viola Ronge, Britta Drees, Monika Lindemann, Uwe Hillen, Harald Engler, Bernhard B Singer, Ralf Küppers
The generation and functions of human peripheral blood (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG(+) memory B cells. This analysis revealed a high similarity of IgM(+)(IgD(+))CD27(+) and IgG(+) memory B cells but also pointed at distinct functional capacities of both subsets. In vitro analyses revealed a tendency of activated IgM(+)IgD(+)CD27(+) B cells to migrate to B-cell follicles and undergo germinal center (GC) B-cell differentiation, whereas activated IgG(+) memory B cells preferentially showed a plasma cell (PC) fate...
February 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25591042/synergistic-inhibition-of-%C3%AE-2-adrenergic-receptor-mediated-alveolar-epithelial-fluid-transport-by-interleukin-8-and-transforming-growth-factor-%C3%AE
#17
Brant M Wagener, Jérémie Roux, Michel Carles, Jean-Francois Pittet
BACKGROUND: Patients with acute respiratory distress syndrome who retain maximal alveolar fluid clearance (AFC) have better clinical outcomes. The release of endogenous catecholamines associated with shock or the administration of β2-adrenergic receptor (β2AR) agonists enhances AFC via a 3'-5'-cyclic adenosine monophosphate-dependent mechanism. The authors have previously reported that transforming growth factor-β1 (TGF-β1) and interleukin-8 (IL-8), two major mediators of alveolar inflammation associated with the early phase of acute respiratory distress syndrome, inhibit AFC upregulation by β2AR agonists via a phosphoinositol-3-kinase (PI3K)-dependent mechanism...
May 2015: Anesthesiology
https://www.readbyqxmd.com/read/25525983/pilot-study-of-association-of-catechol-o-methyl-transferase-rs4680-genotypes-with-acute-kidney-injury-and-tubular-stress-after-open-heart-surgery
#18
Christian Albert, Johanna Kube, Anja Haase-Fielitz, Annemarie Dittrich, Denny Schanze, Martin Zenker, Hermann Kuppe, Roland Hetzer, Rinaldo Bellomo, Peter R Mertens, Michael Haase
AIM: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. PATIENTS & METHODS: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. RESULTS: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0...
2014: Biomarkers in Medicine
https://www.readbyqxmd.com/read/25186490/deletion-of-the-%C3%AE-2a-%C3%AE-2c-adrenoceptors-accelerates-cutaneous-wound-healing-in-mice
#19
Bruna Romana-Souza, Adriana P Nascimento, Patricia C Brum, Andréa Monte-Alto-Costa
The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutaneous wound healing. A full-thickness excisional lesion was performed on the dorsal skin of the α2A/α2C-adrenoceptor knockout and wild-type mice. Seven or fourteen days later, the animals were euthanized and the lesions were formalin-fixed and paraffin-embedded or frozen...
October 2014: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/25041622/supplementation-with-olive-oil-but-not-fish-oil-improves-cutaneous-wound-healing-in-stressed-mice
#20
Alice dos Santos Rosa, Luana Graziella Bandeira, Andréa Monte-Alto-Costa, Bruna Romana-Souza
Supplementation with olive and fish oils reverses the effects of stress on behavioral activities and adrenal activation. However, previous studies have not shown whether supplementation with olive and fish oil could inhibit the effects of stress on cutaneous wound healing. Thus, this study investigated the effects of supplementation with fish or olive oil on cutaneous healing in stressed mice. Mice were subjected to rotational stress and treated with olive or fish oil daily until euthanasia. An excisional lesion was created on each mouse, and 14 days later, the lesions were analyzed...
July 2014: Wound Repair and Regeneration
keyword
keyword
37708
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"