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gastrointestinal stromal tumour

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https://www.readbyqxmd.com/read/27904782/prognostic-values-of-dlk1-for-surgery-and-imatinib-mesylate-adjuvant-therapy-in-gastrointestinal-stromal-tumors
#1
Jia Xu, Ming Wang, Zizhen Zhang, Wenyi Zhao, Chaojie Wang, Lin Tu, Yeqian Zhang, Hui Cao
The Delta-like 1 homolog (DLK1) gene is a paternal imprinting gene located on human chromosome 14q32, a site associated with frequent chromosomal mutations in GIST. The expression level of DLK1 is closely associated with the outcome of tumours. However, no study has reported the DLK1 expression in GIST. Here, we demonstrated that DLK1 showed low expression in GIST patients with low risk according to the modified National Institute of Health (NIH) criteria. With increasing tumour risk level, DLK1 gene and protein expression levels gradually increased...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27900093/primary-gastrointestinal-stromal-tumour-of-the-ileum-pre-operatively-diagnosed-as-an-abdominal-abscess
#2
Patrizia Rubini, Francesco Tartamella
The present case report described the acute presentation, diagnosis and management of a primary gastrointestinal stromal tumour (GIST) of the ileum. A male patient (age, 51 years) was admitted to Maggiore Hospital (Parma, Italy) due to presenting with fever, dysuria and lower abdominal pain. Ultrasonography and computed tomography showed a 7,5×5,5-cm pelvic mass containing air and purulent fluid indicative of an intraperitoneal abscess. The patient was subjected to diagnostic laparoscopy, which revealed a huge, soft cystic mass arising from the small bowel...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27886554/a-biomaterial-assisted-mesenchymal-stromal-cell-therapy-alleviates-colonic-radiation-induced-damage
#3
Lara Moussa, Girish Pattappa, Bastien Doix, Sarra-Louiza Benselama, Christelle Demarquay, Marc Benderitter, Alexandra Sémont, Radia Tamarat, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Noëlle Mathieu
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy to reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able to encapsulate and withstand Ad-MSCs, can overcome these limitations. A silanized hydroxypropylmethyl cellulose (Si-HPMC) hydrogel has been designed and characterized for injectable cell delivery using the operative catheter of a colonoscope...
November 16, 2016: Biomaterials
https://www.readbyqxmd.com/read/27855991/-obscure-gastrointestinal-bleeding-due-to-gastrointestinal-stromal-tumors
#4
Larry Romero-Espinosa, Luis Manuel Souza-Gallardo, José Luis Martínez-Ordaz, Teodoro Romero-Hernández, Mauricio de la Fuente-Lira, Jorge Arellano-Sotelo
BACKGROUND: The gastrointestinal stromal tumours (GIST) are the most common soft tissue sarcomas of the digestive tract. They are usually found in the stomach (60-70%) and small intestine (25-30%) and, less commonly, in the oesophagus, mesentery, colon, or rectum. The symptoms present at diagnosis are, gastrointestinal bleeding, abdominal pain, abdominal mass, or intestinal obstruction. The type of symptomatology will depend on the location and size of the tumour. The definitive diagnosis is histopathological, with 95% of the tumours being positive for CD117...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27847538/gastrointestinal-stromal-tumour-of-the-stomach-in-an-8-year-old-boy
#5
James Dc Coates
We report a case of an 8-year-old boy who underwent an ultrasound for investigation of a left upper quadrant mass and who was subsequently diagnosed with gastrointestinal stromal tumour of his stomach. Abdominal ultrasound showed a large cystic mass in the left upper abdomen which was further characterised by magnetic resonance imaging. At laparotomy, a large cystic lesion was excised from his stomach, which was confirmed at histology to be a gastrointestinal stromal tumour. We briefly discuss the presentation and imaging findings of paediatric gastrointestinal stromal tumour and how it differs from the adult form of the disease and treatments...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27844452/urgency-surgical-treatment-for-duodenal-gists-analysis-of-aged-patients-and-review-of-the-literature
#6
Carlo Boselli, Roberto Cirocchi, Alessandro Gemini, Francesco Barberini, Veronica Grassi, Stefano Avenia, Andrea Polistena, Alessandro Sanguinetti, Daniele Pironi, Alberto Santoro, Renata Tabola, Nicola Avenia
INTRODUCTION: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms (85%) of the gastrointestinal (GI) tract; duodenal GISTs constitute 3-5% of all GISTs and represent 10-30% of all malignant tumours of the duodenum. Rarely, patients present severe bowel obstruction, perforation or severe bleeding. The radical resection with complete removal of the tumour remains the main therapeutic approach. We performed a local resection in patients with suspected GIST admitted for emergency treatment for GI bleeding...
November 14, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27843616/update-on-clinical-research-and-state-of-the-art-management-of-patients-with-advanced-sarcomas-and-gist
#7
REVIEW
Yannis Metaxas, Georgios Oikonomopoulos, George Pentheroudakis
Sarcomas constitute a rare group of malignancies. According to histology, different treatment options are effective. For gastrointestinal stromal tumours (GISTs), targeted treatment with imatinib controls about 20% of advanced or metastatic disease, whereas chemotherapy is more effective for the rest of the sarcomas. Currently, new targeted treatments are emerging, showing activity in cases resistant to established primary treatment. On the other hand, the exciting results of immunotherapy for other solid tumours, for example, melanoma and lung cancer, make it a promising option in the fight against sarcomas...
2016: ESMO Open
https://www.readbyqxmd.com/read/27843612/tki-induced-pure-red-cell-aplasia-first-case-report-of-pure-red-cell-aplasia-with-both-imatinib-and-nilotinib
#8
Bishesh Sharma Poudyal, Sampurna Tuladhar, Bishal Gyawali
Tyrosine-kinase inhibitors (TKIs) represent the only hopes for long-term survival for patients with chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours. Thus, uninterrupted use of TKIs is of importance in such patients. Pure red cell aplasia (PRCA) is a rare disorder, not previously known to be associated with TKIs. We present, to the best of our knowledge, the first case of a patient with CML who developed PRCA secondary to both imatinib and nilotinib. Although PRCA was controlled on withdrawal of TKI, TKI continuation in the patient with CML is important...
2016: ESMO Open
https://www.readbyqxmd.com/read/27773150/dual-diagnosis-of-gastrointestinal-stromal-tumour-and-papillary-renal-cell-carcinoma-by-upper-gastrointestinal-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-a-case-report
#9
https://www.readbyqxmd.com/read/27761711/computed-tomography-features-and-predictive-findings-of-ruptured-gastrointestinal-stromal-tumours
#10
Jin Sil Kim, Hyun Jin Kim, Seong Ho Park, Jong Seok Lee, Ah Young Kim, Hyun Kwon Ha
OBJECTIVES: To evaluate the CT features of ruptured GISTs and factors that might be predictive of rupture through comparison with CTs taken prior to rupture and CTs of non-ruptured GIST. METHODS: Forty-nine patients with ruptured GIST and forty-nine patients with non-ruptured GIST matched by age, gender and location were included. Clinical data including pharmacotherapy were reviewed. The imaging features were analyzed. Prior CT obtained before rupture were evaluated...
October 19, 2016: European Radiology
https://www.readbyqxmd.com/read/27751846/safety-and-efficacy-of-regorafenib-in-patients-with-advanced-soft-tissue-sarcoma-regosarc-a-randomised-double-blind-placebo-controlled-phase-2-trial
#11
Olivier Mir, Thomas Brodowicz, Antoine Italiano, Jennifer Wallet, Jean-Yves Blay, François Bertucci, Christine Chevreau, Sophie Piperno-Neumann, Emmanuelle Bompas, Sébastien Salas, Christophe Perrin, Corinne Delcambre, Bernadette Liegl-Atzwanger, Maud Toulmonde, Sarah Dumont, Isabelle Ray-Coquard, Stéphanie Clisant, Sophie Taieb, Cécile Guillemet, Maria Rios, Olivier Collard, Laurence Bozec, Didier Cupissol, Esma Saada-Bouzid, Christine Lemaignan, Wolfgang Eisterer, Nicolas Isambert, Loïc Chaigneau, Axel Le Cesne, Nicolas Penel
BACKGROUND: Regorafenib is a multikinase inhibitor with proven activity in refractory gastrointestinal stromal tumours and chemotherapy-refractory advanced colorectal cancers. We assessed this agent's efficacy and safety in patients with metastatic soft tissue sarcomas previously treated with anthracycline. METHODS: In this randomised, double-blind, phase 2 trial undertaken in France and Austria, we enrolled patients aged 18 years and older with advanced soft tissue sarcomas who had received previous doxorubicin or other anthracycline treatment...
October 14, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27678251/outcomes-of-annual-surveillance-imaging-in-an-adult-and-paediatric-cohort-of-succinate-dehydrogenase-b-mutation-carriers
#12
Nicola Tufton, Lucy Shapiro, Umasuthan Srirangalingam, Polly Richards, Anju Sahdev, Ajith V Kumar, Lorraine McAndrew, Lee Martin, Daniel Berney, John Monson, Shern L Chew, Mona Waterhouse, Maralyn Druce, Márta Korbonits, Karl Metcalfe, William M Drake, Helen L Storr, Scott A Akker
OBJECTIVE: For 'asymptomatic carriers' of the succinate dehydrogenase subunit B (SDHB) gene mutations, there is currently no consensus as to the appropriate modality or frequency of surveillance imaging. We present the results of a surveillance programme of SDHB mutation carriers. DESIGN: Review of clinical outcomes of a surveillance regimen in patients identified to have an SDHB gene mutation, based on annual MRI, in a single UK tertiary referral centre. PATIENTS: A total of 92 patients were identified with an SDHB gene mutation...
September 28, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27627080/-the-skin-a-mirror-of-internal-diseases
#13
Kateřina Jůzlová, Jana Hercogová
UNLABELLED: The knowledge of the relationship between dermatologic manifestations and disorders and internal diseases may facilitate early identification of general disease. The report aims to provide an overview of dermatologic manifestations of gastrointestinal disorders, non-specific inflammatory bowel disease and gastrointestinal stromal tumours, and skin alterations related to diabetes mellitus. The role of a dermatologist is primarily to diagnose dermatoses. KEY WORDS: diabetes mellitus - dermatoses - m...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27604671/dedifferentiated-liposarcoma-of-sigmoid-mesocolon-a-case-report
#14
Silviu Constantinoiu, Ion-Florin Achim, Oana-Eliza Cretu, Tatiana Dumitru, Adrian Constantin, Simona Enache, Ioan Nicolae Mates
Dedifferentiated liposarcoma is a liposarcoma that contains a well-differentiated liposarcoma component juxtaposed to areas of high-grade non-lipogenic sarcoma and was believed to occur from well-differentiated liposarcoma after several years. Dedifferentiated liposarcoma most commonly occurs in the retroperitoneum, while an intraperitoneal location is extremely rare, only seven cases have been reported in literature. Many pathologists recognize that a large number of intra-abdominal poorly differentiated sarcomas are dedifferentiated liposarcomas...
July 2016: Chirurgia
https://www.readbyqxmd.com/read/27566016/prognosis-and-management-of-adult-wild-type-gastrointestinal-stromal-tumours-gists-a-pooled-analysis-and-review-of-literature
#15
N R Bhatt, D Collins, P Crotty, P F Ridgway
A pooled review was performed to determine survival in adult WT GIST (Wild Type GastroIntestinal Stromal Tumours) and compare the same with pediatric WT GISTs. Electronic databases were searched using the terms "Wild type" AND "GIST". Eighty-two adult patients from 14 studies were included in the pooled analysis. Cumulative survival was greater than 50% in both age groups, hence medial survival could not be computed. Mean survival in adults was 15.7 years ± 0.78 and in children was 18.8 years ± 1.3 (p = 0...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27563455/treatment-of-non-resectable-and-metastatic-gastrointestinal-stromal-tumors-experience-with-the-use-of-tyrosine-kinase-inhibitors-in-a-third-level-hospital-in-mexico
#16
Abdel Karim Dip Borunda, Alberto Pimentel Renteria, Miguel Pluma Jiménez, Mario Pérez Martínez, Gloria Martínez Martínez, Samuel Rivera Rivera, Rocío Grajales Álvarez, Yolanda Bautista Aragón, Miguel Quintana Quintana, Juan Alejandro Silva
BACKGROUND: Stromal tumors of the digestive tract are uncommon malignant diseases, are subclassified as leiomyosarcomas and Gastrointestinal Stromal Tumors (GIST) depending on the molecular expression of tyrosine kinase receptor KIT (CD117). GISTs represent 1% of malignant tumors affecting this anatomical site. Localized tumours diseases are reasonably well controlled by surgical resection and several criteria define the need for adjuvant therapy. In the case of metastatic disease a poor prognosis has been reported with systemic treatment based on chemotherapy...
August 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27554383/gastric-inflammatory-fibroid-polyp-mimicking-a-gastrointestinal-stromal-tumour
#17
Marco Silva, Andreia Albuquerque, Hélder Cardoso, Jennifer Costa, Guilherme Macedo
Inflammatory fibroid polyp of the gastrointestinal tract is a rare, benign neoplasm, most frequently located in the gastric antrum. Symptoms depend on the location and the size of the lesion. Biopsies are limited for the diagnosis of inflammatory fibroid polyps and diagnosis may not be possible until resection. The authors present a case of a 55-year-old woman, presenting with an upper gastrointestinal bleeding due to a large gastric inflammatory fibroid polyp imitating a gastrointestinal stromal tumor.
August 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27530882/gastrointestinal-stromal-tumour-in-neurofibromatosis-1-18f-fdg-pet-ct-imaging
#18
Gavin Sugrue, Ba D Nguyen
No abstract text is available yet for this article.
August 16, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27527414/the-human-tyrosine-kinase-kit-and-its-gatekeeper-mutant-t670i-show-different-kinetic-properties-implications-for-drug-design
#19
Miroslava Kissova, Giovanni Maga, Emmanuele Crespan
The tyrosine kinase Kit, a receptor for Stem Cell Factor, is involved, among others, in processes associated to cell survival, proliferation and migration. Upon physiological conditions, the activity of Kit is tightly regulated. However, primary mutations that lead to its constitutive activation are the causal oncogenic driver of gastrointestinal stromal tumours (GISTs). GISTs are known to be refractory to conventional therapies but the introduction of Imatinib, a selective inhibitor of tyrosine kinases Abl and Kit, significantly ameliorated the treatment options of GISTs patients...
October 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27522924/-partial-duodenectomy-as-a-therapeutic-option-in-multiple-duodenal-gastrointestinal-stromal-tumour-associated-with-neurofibromatosis-type-1
#20
Antonio Palomeque Jiménez, José Rubio López, Beatriz Pérez Cabrera, José Antonio Jiménez Ríos
No abstract text is available yet for this article.
August 11, 2016: Gastroenterología y Hepatología
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