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gastrointestinal stromal tumour

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https://www.readbyqxmd.com/read/29755907/the-100-most-influential-papers-and-recent-trends-in-the-field-of-gastrointestinal-stromal-tumours-a-bibliometric-analysis
#1
Khadijah Siddiq, Hira F Akbar, Meeshal Khan, Amna A Siddiqui, Salman Nusrat, Jean Y Blay
Background Bibliometric analysis is a statistical tool used to examine the exponential growth in medical research. Many analogous analyses have been conducted, but none existed for gastrointestinal stromal tumors (GISTs). Hence, we conducted a citation analysis of the hundred most cited and recently published articles on this topic. Methods Scopus was chosen as the primary database, through which the top 100 and recent publications were ranked according to the citation count and were then analysed. Results The 100 most cited articles were published between 1992 and 2013, among which the greatest number of articles were published in the years 2002 (n = 15) and 2006 (n = 11)...
March 12, 2018: Curēus
https://www.readbyqxmd.com/read/29752127/implementation-of-next-generation-sequencing-technology-for-somatic-mutation-detection-in-routine-laboratory-practice
#2
Tindaro Giardina, Cleo Robinson, Fabienne Grieu-Iacopetta, Michael Millward, Barry Iacopetta, Dominic Spagnolo, Benhur Amanuel
The introduction of next generation sequencing (NGS) in the routine diagnostic setting is still in the development phase and has been limited by its complexity. Targeted NGS offers an attractive alternative to performing multiple single target assays and is very useful in meeting the increasing clinical demand for testing of multiple genetic aberrations in cancer specimens. To this end, we carried out a blinded validation study on 113 tumours in a diagnostic laboratory and compared mutation results from targeted NGS with those from Sanger sequencing, pyrosequencing, competitive allele specific TaqMan polymerase chain reaction (CAST PCR) and Cobas assays...
May 8, 2018: Pathology
https://www.readbyqxmd.com/read/29740484/establishment-of-a-gist-t1-gastrointestinal-stromal-tumour-cell-line-resistant-to-imatinib-mesylate
#3
Yongjian Zhou, Jiabi Chen, Xiaoyuan Weng, Guosheng Lin, Zicheng Huang, Hanli Shui
In the present study, imatinib mesylate (IM) was used to induce resistance in the gastrointestinal stromal tumour (GIST) cell line, GIST-T1, to establish a stable resistant cell line. The growth characteristics and expression profile of the established cell line were compared with those of the parental cell line. Additionally, the resistance mechanism of the gastrointestinal stromal tumours was preliminarily investigated. The GIST-T1 cells were cultured in vitro , and the drug was administered in the logarithmic phase of cell growth using intermittent dosing with increasing concentrations to obtain a drug-resistant cell line by repeated induction...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29717299/anorectal-gastrointestinal-stromal-tumour-a-case-treated-with-radical-surgery
#4
Arbin Joshi
Gastrointestinal Stromal Tumour involving rectum and anal canal is an extremely rare entity. This is a case report of a 47 years lady presented with fresh rectal bleed associated with rectal pain and foul smelling rectal mucus discharge. On rectal examination, she had a firm mass palpable about 1.5 cm from anal verge. Considering the size of the tumour and its close proximity with cervix and involvement of levator muscles, extralevator abdominal perineal excision of rectum was undertaken with good recovery after surgery...
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#5
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29664995/nationwide-trends-in-the-incidence-and-outcome-of-patients-with-gastrointestinal-stromal-tumour-in-the-imatinib-era
#6
W T A van der Graaf, R Tielen, J J Bonenkamp, V Lemmens, R H A Verhoeven, J H W de Wilt
BACKGROUND: The incidence, treatment and outcome of patients with newly diagnosed gastrointestinal stromal tumour (GIST) were studied in an era known for advances in diagnosis and treatment. METHODS: Nationwide population-based data were retrieved from the Netherlands Cancer Registry. All patients with GIST diagnosed between 2001 and 2012 were included. Primary treatment, defined as any treatment within the first 6-9 months after diagnosis, was studied. Age-standardized incidence was calculated according to the European standard population...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29658339/refractory-hypercalcaemia-secondary-to-localised-gastrointestinal-stromal-tumour
#7
T Hart, D Sinitsky, A Shamsiddinova, A Rohatgi
Gastrointestinal stromal tumours are a rare form of intra-abdominal neoplasm derived from mesenchymal tissue, typically presenting with abdominal pain, anaemia or bleeding into the bowel or abdominal cavity. Hypercalcaemia is an unusual complication, having been documented in only seven previous patients, all of whom had advanced metastatic disease. We present a case of treatment-resistant hypercalcaemia in a patient with non-metastatic gastrointestinal stromal tumour, which resolved following excision of the tumour...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29595183/gastrointestinal-stromal-tumours-of-stomach-robot-assisted-excision-with-the-da-vinci-surgical-system-regardless-of-size-and-location-site
#8
Niccolo Furbetta, Matteo Palmeri, Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Saverio Latteri, Emanuele Marciano, Andrea Moglia, Alfred Cuschieri, Giulio Di Candio, Franco Mosca, Luca Morelli
AIMS: The role of minimally invasive surgery of gastrointestinal stromal tumours (GISTs) of the stomach remains uncertain especially for large and/or difficult located tumours. We are hereby presenting a single-centre series of robot-assisted resections using the da Vinci Surgical System (Si or Xi). SUBJECTS AND METHODS: Data of patients undergoing robot-assisted treatment of gastric GIST were retrieved from the prospectively collected institutional database and a retrospective analysis was performed...
March 23, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29592983/rare-cause-of-fever-of-unknown-origin-gastrointestinal-stromal-tumour
#9
Manjunath Havalappa Dodamani, Rajiv Ranjan Kumar, Mayur Parkhi, Rajendar Basher
A 44-year-old man presented with fever (low to high grade) for 2-month duration despite treatment with oral antibiotics and antipyretics. Further, enquiry did not yield any potentially explanatory clues to a diagnosis. Physical examination revealed only left axillary lymphadenopathy, but was otherwise unremarkable. A number of diagnosis included tuberculosis, malignancy, lymphoma, connective disease disorder and infective endocarditis. Further evaluation revealed severe anaemia due to iron deficiency which was supported with blood transfusion and oral iron supplementation...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29579329/prediction-of-morbidity-following-cytoreductive-surgery-for-metastatic-gastrointestinal-stromal-tumour-in-patients-on-tyrosine-kinase-inhibitor-therapy
#10
M Fairweather, M J Cavnar, G Z Li, M M Bertagnolli, R P DeMatteo, C P Raut
BACKGROUND: Although cytoreductive surgery has been shown to be beneficial in carefully selected patients with metastatic gastrointestinal stromal tumours (GISTs) treated with tyrosine kinase inhibitors (TKIs), factors predictive of postoperative morbidity have not been investigated previously. METHODS: A surgical complexity score for GIST metastasectomy (GM-SCS) composed of patient-related and surgical factors was assigned retrospectively to patients with metastatic GIST treated with TKI therapy and surgery at two institutions between 2002 and 2014...
March 26, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29567631/interventional-radiology-role-in-the-treatment-of-sarcomas
#11
REVIEW
Thierry de Baere, Lambros Tselikas, Guillaume Gravel, Antoine Hakime, Frederic Deschamps, Charles Honoré, Olivier Mir, Axel Lecesne
In bone and soft tissue sarcomas (STS), surgery was to the only local curative treatment, but recently, radiation therapy and interventional radiology has evolved to potentially curative treatment, namely in small size tumours. Indication for local treatment in STS needs validation in multidisciplinary team. Most will agree on local treatment for single metastatic location in a well-controlled disease and for no local treatment in a rapidly evolving multi-metastatic disease. The challenge is in patients who are in between, for whom benefit of disease control on overall survival should be evaluated...
May 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29564142/gastric-schwannoma-a-rare-benign-mimic-of-gastrointestinal-stromal-tumour
#12
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29534341/gastrointestinal-stromal-tumour-with-an-unusual-presentation-as-a-huge-prostatic-mass-a-case-report
#13
Jianjian Xiang, Jiangfeng Li, Song Wang, Xiao Wang
No abstract text is available yet for this article.
March 13, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29524855/melena-as-an-unusual-presentation-of-gastrointestinal-stromal-tumour-a-case-report
#14
G Mulkerrin, N M Hogan, M Sheehan, M R Joyce
INTRODUCTION: Gastrointestinal Stromal Tumors (GISTs) are a rare slow growing malignancy, accounting for less than 1% of all gastrointestinal (GI) tract tumors. These tumors are usually discovered incidentally by endoscopy, surgery or radiology. However on occasions they may present with significant symptoms including GI blood loss. This case report discusses an atypical presentation of a GIST in a 57-year-old female. CASE PRESENTATION: A 57-year-old woman presented to the emergency department following one episode of melena...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29507015/the-mass-effect-of-a-slowly-growing-gist
#15
Deepali Prakash, Leandro Siragusa, Saj Wajed, Antonio Manzelli
Gastrointestinal stromal tumours (GISTs) are typically defined as solid masses arising from the GI tract, most commonly from the stomach and small intestine. They seldom present in a cystic form. Management of cystic masses arising from the GI tract may pose a diagnostic predicament. We had one such case that presented itself with complaints of a slow growing intra-abdominal mass. An ultrasound scan demonstrated a thick-walled cystic lesion arising from the pelvis. Further imaging evaluations in the form of a CT scan revealed a complex large cystic mass arising from left upper quadrant (see Figure 1)...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29492250/gastrointestinal-stromal-tumour-as-a-rare-association-with-neurofibromatosis-type-1
#16
Rhona H Hurley, Michael McCormick, Mohamad Elhassan, Gary Nicholson
Gastrointestinal stromal tumours (GIST) are rare tumours of mesenchymal origin. These can be associated with neurofibromatosis type 1 (NF1), which is an autosomal dominant disorder. The prevalence of GIST in NF1 is estimated at 3.9-25%. This paper describes the presentation of a GIST arising from the jejenum in a 75-year-old lady with NF1, who presented with gastrointestinal bleeding. This was diagnosed by CT angiography. She was managed with laparotomy, with resection of small bowel, and an ischaemic segment of large bowel with two primary anastomoses...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29487722/prognostic-role-of-the-primary-tumour-site-in-patients-with-operable-small-intestine-and-gastrointestinal-stromal-tumours-a-large-population-based-analysis
#17
Hua Ye, Hua Xin, Qi Zheng, Qijun Shen, Wenyu Dai, Feng Wu, Cheng Zheng, Ping Chen
The postoperative recurrence risk of gastrointestinal stromal tumour (GIST) should be estimated when considering adjuvant systemic therapy. Previous studies in the literature have suggested that small intestinal GISTs are more aggressive than gastric GISTs. We assessed the prognostic role of the primary tumour site in patients with operable GIST to compare the outcomes of gastric and small intestinal GISTs over a decade of treatment. The Surveillance, Epidemiology, and End Results (SEER) database was queried for cases of gastric and small intestinal GISTs between 2004 and 2014 using the GIST-specific histology code (ICD-O-3 code 8936), and only patients with tissues sampled by surgical resection were selected for this study...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29484926/giant-gastrointestinal-stromal-tumour-of-the-stomach-a-case-report-with-surgical-treatment
#18
Y Zhang, Y J Wang, C J Lu, G M Shu, T Bai
We report a case of giant gastrointestinal stromal tumour of the stomach in a 71-year-old woman, with emphasis on its going through surgical resection. The physical examination and radiological findings revealed that a giant mass occupied most of the abdominal cavity. The patient underwent an en-block resection of the mass, partial resection of the distal stomach and Billroth II gastrojejunostomy. The pathological diagnosis was gastrointestinal stromal tumour. The patient had a long-term disease-free survival...
March 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29472628/ultrastructural-and-immunohistochemical-features-of-telocytes-in-placental-villi-in-preeclampsia
#19
Natalia V Nizyaeva, Tatiana V Sukhacheva, Roman A Serov, Galina V Kulikova, Marina N Nagovitsyna, Natalia E Kan, Victor L Tyutyunnik, Stanislav V Pavlovich, Rimma A Poltavtseva, Ekaterina L Yarotskaya, Aleksandr I Shchegolev, Gennadiy T Sukhikh
A new cell type, interstitial Cajal-like cell (ICLC), was recently described in different organs. The name was recently changed to telocytes (TCs), and their typical thin, long processes have been named telopodes (Tp). TCs regulate the contractile activity of smooth muscle cells and play a role in regulating vessel contractions. Although the placenta is not an innervated organ, we believe that TCs are present in the placenta. We studied placenta samples from physiological pregnancies and in different variants of preeclampsia (PE)...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449894/personalization-of-regorafenib-treatment-in-metastatic-gastrointestinal-stromal-tumours-in-real-life-clinical-practice
#20
Margherita Nannini, Maria Concetta Nigro, Bruno Vincenzi, Elena Fumagalli, Giovanni Grignani, Lorenzo D'Ambrosio, Giuseppe Badalamenti, Lorena Incorvaia, Raffaella Bracci, Silvia Gasperoni, Maristella Saponara, Lidia Gatto, Valentina Indio, Annalisa Astolfi, Valerio Di Scioscio, Paolo G Casali, Giuseppe Tonini, Massimo Aglietta, Antonio Russo, Guido Biasco, Maria A Pantaleo
Background: Regorafenib (REG) has now been approved as the standard third-line therapy in metastatic gastrointestinal stromal tumour (GIST) patients at the recommended dose and schedule of 160 mg once daily for the first 3 weeks of each 4-week cycle. However, it has a relevant toxicity profile that mainly occurs within the first cycles of therapy, and dose and schedule adjustments are often required to reduce the frequency or severity of adverse events and to avoid early treatment discontinuation...
December 2017: Therapeutic Advances in Medical Oncology
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