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gastrointestinal stromal tumour

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https://www.readbyqxmd.com/read/29114386/suppression-of-inflammation-and-tissue-damage-by-a-hookworm-recombinant-protein-in-experimental-colitis
#1
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29110655/treatment-of-gastrointestinal-stromal-tumours-in-paediatric-and-young-adult-patients-with-sunitinib-a-multicentre-case-series
#2
Piotr Rutkowski, Heather Magnan, Alexander J Chou, Charlotte Benson
BACKGROUND: Gastrointestinal stromal tumours (GIST) are rarely encountered mesenchymal tumours of the gastrointestinal tract (1.5 people per 100,000/year) that are even more rarely seen in paediatric patients (1-2% of all cases). The standard treatment for advanced adult GIST is imatinib with sunitinib as a second-line option. Although the efficacy and tolerability of sunitinib in adults with GIST has been established, little is known of the profile of sunitinib in paediatric/young adult patients with GIST given the rarity of this disease...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29073582/elderly-patients-with-gastrointestinal-stromal-tumour-gist-receive-less-treatment-irrespective-of-performance-score-or-comorbidity-a-retrospective-multicentre-study-in-a-large-cohort-of-gist-patients
#3
Sheima Farag, Frits van Coevorden, Esther Sneekes, Dirk J Grunhagen, Anna K L Reyners, Pieter A Boonstra, Winette T van der Graaf, Hans J Gelderblom, Neeltje Steeghs
OBJECTIVE: Although gastrointestinal stromal tumours (GIST) predominantly occur in older patients, data on treatment patterns in elderly GIST patients are scarce. METHODS: Patients registered in the Dutch GIST Registry (DGR) from January 2009 until December 2016 were included. Differences in treatment patterns between elderly (≥75 years) and younger patients were compared. Multivariate analyses were conducted using logistic regression. RESULTS: Data of 145 elderly and 665 non-elderly patients were registered (median age 78 and 60 years respectively)...
October 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29070651/gene-of-the-month-sdh
#4
REVIEW
Alessandro Pietro Aldera, Dhirendra Govender
Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy...
October 25, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29054076/genetic-polymorphisms-in-angiogenesis-related-genes-are-associated-with-worse-progression-free-survival-of-patients-with-advanced-gastrointestinal-stromal-tumours-treated-with-imatinib
#5
Michiel C Verboom, Jacqueline S L Kloth, Jesse J Swen, Tahar van der Straaten, Judith V M G Bovée, Stefan Sleijfer, Anna K L Reyners, Ron H J Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom
BACKGROUND: Imatinib 400 mg per day is first-line therapy for patients with gastrointestinal stromal tumours (GISTs). Although clinical benefit is high, progression-free survival (PFS) is variable. This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST. METHODS: In 227 patients a pharmacogenetic pathway analysis was performed...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29044935/unusual-presentation-of-metastatic-gastrointestinal-stromal-tumour
#6
Hao-Yun Yap, Tze-Wei Chng, Brian K P Goh
No abstract text is available yet for this article.
October 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28983577/early-experience-with-robot-assisted-laparoscopic-hepatobiliary-and-pancreatic-surgery-in-singapore-single-institution-experience-with-20-consecutive-patients
#7
Brian Kp Goh, Ser-Yee Lee, Chung-Yip Chan, Jen-San Wong, Peng-Chung Cheow, Alexander Yf Chung, London Lpj Ooi
INTRODUCTION: Presently, experience with robot-assisted laparoscopic (RAL) hepatobiliary and pancreatic (HPB) surgery remains limited worldwide. In this study, we report our early experience with RAL HPB surgery in Singapore. METHODS: A retrospective review was conducted of the first 20 consecutive patients who underwent RAL HPB surgery at a single institution over a 34-month period from February 2013 to November 2015. The 20 cases were performed by three principal surgeons, of which 17 (85...
October 6, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28969853/texture-analysis-of-ct-images-in-predicting-malignancy-risk-of-gastrointestinal-stromal-tumours
#8
S Liu, X Pan, R Liu, H Zheng, L Chen, W Guan, H Wang, Y Sun, L Tang, Y Guan, Y Ge, J He, Z Zhou
AIM: To explore the role of texture analysis of computed tomography (CT) images in predicting the malignancy risk of gastrointestinal stromal tumours (GISTs). MATERIALS AND METHODS: Seventy-eight patients with histopathologically confirmed GISTs underwent preoperative CT. Texture analysis was performed on unenhanced and contrast-enhanced CT images, respectively. Fourteen CT texture parameters were obtained and compared among GISTs at different malignancy risks with one-way analysis of variance or independent-samples Kruskal-Wallis test...
September 29, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28969200/gastroduodenal-intussusception-due-to-gastrointestinal-stromal-tumour-gist
#9
Abdul Rehman Abdul Jameel, Durairaj Segamalai, Gnanasekaran Murugaiyan, Rajendran Shanmugasundaram, Naganath Babu Obla
Gastroduodenal intussusception is the rarest forms of adult intussusception. We present a case of gastroduodenal intussusception due to a gastric Gastrointestinal Stromal Tumour (GIST). The patient was a 65-year-old female who clinically presented as acute gastric outlet obstruction. The patient was managed by gentle reduction of the intussusception, followed by wedge resection of the tumour. She was relieved of her symptoms and recurrence free for past one year.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28950990/recent-advances-in-the-diagnosis-of-soft-tissue-tumours
#10
REVIEW
Inga-Marie Schaefer, Christopher D M Fletcher
Soft tissue tumours are relatively rare, but are diagnostically challenging as they comprise a large spectrum of diagnostic entities. Substantial advances have been made in recent years in identifying the underlying recurrent chromosomal and genomic alterations in a significant subset of soft tissue tumours, and this continues to enrich our understanding of the biological mechanisms of tumour development and progression. Ongoing validation and integration of these findings into existing pathological-diagnostic algorithms has led to re- or subclassification of diagnostic categories and will continue to shape a more nuanced (and hopefully clinically relevant) tumour classification system in the future...
September 23, 2017: Pathology
https://www.readbyqxmd.com/read/28946040/hif-2alpha-achilles-heel-of-pseudohypoxic-subtype-paraganglioma-and-other-related-conditions
#11
Sri Harsha Tella, David Taïeb, Karel Pacak
Paragangliomas (PGLs) belong to the most hereditary endocrine tumours. The existence of mutated HIF2A in these tumours, the role of oncometabolites on HIFs stabilisation and a recent concept proposing how hereditary PGLs converge on the hypoxia-signalling pathway, brought solid evidence of the existence of PGL hypoxiom. Hypoxia-inducible factor 2alpha (HIF-2α) antagonists -PT2385, and PT2399 have been shown to have promising results in the management of clear cell renal cell carcinoma by targeting the HIF-2α pathway in recent and ongoing clinical trials (PT2799)...
September 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28900473/resection-of-rectal-gist-using-a-novel-technique-a-report-of-two-cases
#12
Osama Eldamshety, Islam H Metwally, Elsayed Ghoneem, Wagdi F Elkashef
Rectal gastrointestinal stromal tumours (GISTs) are uncommon tumours and usually present with large sizes. We present two cases of rectal GIST. Imatinib was used in the setting of neoadjuvant and adjuvant therapy. Both tumours were resected transanally by the transanal endoscopic operation (TEO) platform. Oncosurgeons are recommended to implement sphincter-sparing surgeries for these cases.
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28882125/evidence-mapping-based-on-systematic-reviews-of-therapeutic-interventions-for-gastrointestinal-stromal-tumors-gist
#13
Mónica Ballesteros, Nadia Montero, Antonio López-Pousa, Gerard Urrútia, Ivan Solà, Gabriel Rada, Hector Pardo-Hernandez, Xavier Bonfill
BACKGROUND: Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. METHODS: We followed the methodology of Global Evidence Mapping (GEM)...
September 7, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28842575/treatment-patterns-efficacy-and-toxicity-of-regorafenib-in-gastrointestinal-stromal-tumour-patients
#14
Gustavo Schvartsman, Michael J Wagner, Behrang Amini, Chrystia M Zobniw, Van Anh Trinh, Andrea G Barbo, Heather Y Lin, Wei-Lien Wang, Anthony Paul Conley, Vinod Ravi, Dejka M Araujo, Maria Alejandra Zarzour, Robert S Benjamin, Shreyaskumar Patel, Neeta Somaiah
Regorafenib was approved as third-line therapy for advanced Gastrointestinal Stromal Tumour (GIST) at a starting dose of 160 mg daily 3 weeks on, 1 week off, based on improvement in progression free survival over placebo (4.8 vs. 0.9 months), but the response rate was low at 4.5%. Given the high toxicity rate in GIST patients, there is variability in the post-marketing dosing of regorafenib. We aimed to summarize our experience regarding prescribing patterns, efficacy and toxicity of regorafenib and determine the role of response assessment by Choi criteria in GIST patients...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839880/gastrointestinal-stromal-tumours-gists-an-insight-into-clinical-practice-with-review-of-literature
#15
M J McDonnell, S Punnoose, Y K S Viswanath, N J Wadd, A Dhar
BACKGROUND: Gastrointestinal stromal tumours (GISTs) are rare mesenchymal tumours of the gastrointestinal tract. We retrospectively reviewed the clinical management of all patients with GIST presenting to a regional multidisciplinary upper gastrointestinal cancer group in the north of England. METHODS: Clinical, pathological, immunohistochemical treatment strategies, follow-up and outcome data on all patients with GIST between 2007 and 2012 were reviewed. Tumours were categorised by risk according to the National Institutes of Health (NIH) and AFIP models...
January 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28761758/the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale-field-tested-in-infrequent-tumour-entities-an-extended-analysis-of-its-feasibility-at-the-medical-university-of-vienna
#16
Barbara Kiesewetter, Markus Raderer, Gerald W Prager, Thorsten Fuereder, Christine Marosi, Matthias Preusser, Michael Krainer, Gottfried J Locker, Thomas Brodowicz, Christoph C Zielinski
BACKGROUND: The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a new tool to quantify the clinical benefit that may be anticipated from a novel anticancer treatment. We present here an analysis on the feasibility of the ESMO-MCBS in less frequent tumour entities. METHODS: This study evaluates the practicability of the ESMO-MCBS for metastatic neuroendocrine tumours (NETs), soft tissue sarcomas, glioblastoma, thyroid cancer, pancreatic cancer, head/neck cancer, urothelial cancer and ovarian cancer at the Medical University Vienna...
2017: ESMO Open
https://www.readbyqxmd.com/read/28751509/giant-oesophageal-gastrointestinal-stromal-tumour-presenting-with-dyspnoea-and-clubbed-fingers
#17
Yurie Yamamoto, Yosuke Sasaki, Michio Kougame, Naobumi Tochigi
Gastrointestinal stromal tumours (GISTs) are mesenchymal neoplasms of the gastrointestinal tract originating from the interstitial cells of Cajal. Giant oesophageal GISTs are rare since the oesophagus is rarely the primary site of GISTs, and they are usually diagnosed early due to complaints such as dysphagia. We present the case of a giant oesophageal GIST presenting with prominent clubbing. The case underlined the diagnostic importance of clubbing and the careful consideration of chemotherapy. Although clubbed fingers associated with GISTs are rare, our experience demonstrates the importance of physicians' recognition of clubbing as a paraneoplastic phenomenon for early diagnosis of malignancies since patients seldom notice their own clubbing by themselves...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28750235/investigation-of-the-effect-of-plasma-albumin-levels-on-regorafenib-induced-hepatotoxicity-using-a-validated-liquid-chromatography-tandem-mass-spectrometry-method
#18
Yi Yun Pang, Yeong Lan Tan, Han Kiat Ho
Regorafenib is an oral multikinase inhibitor indicated for metastatic colorectal cancer and gastrointestinal stromal tumour. Due to its extensive plasma protein binding and low calculated hepatic extraction ratio, the hepatotoxicity observed with usage of the drug may be related to its plasma exposure. To investigate the highly dynamic free:bound drug concentration for regorafenib in the plasma, a bioanalytical liquid chromatography-tandem mass spectrometric assay was developed and validated in human plasma...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28744850/the-expression-of-hematopoietic-progenitor-cell-antigen-cd34-is-regulated-by-dna-methylation-in-a-site-dependent-manner-in-gastrointestinal-stromal-tumours
#19
Irina Bure, Alexander Braun, Claudia Kayser, Helene Geddert, Inga-Marie Schaefer, Silke Cameron, Michael B Ghadimi, Philipp Ströbel, Martin Werner, Arndt Hartmann, Stefan Wiemann, Abbas Agaimy, Florian Haller, Evgeny A Moskalev
The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-dependent expression. Two sample sets of primary GISTs were interrogated including 52 fresh-frozen and 134 paraffin-embedded and formalin-fixed specimens. DNA methylation analysis was performed by HumanMethylation450 BeadChip array in three cell lines derived from gastric and intestinal GISTs, and differentially methylated CpG sites were established upstream of CD34...
December 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28736068/gastrointestinal-stromal-tumour-and-second-tumours-a-literature-review
#20
REVIEW
Rafael Núñez-Martín, Ricardo Cubedo Cervera, Mariano Provencio Pulla
There are several tumours associated with gastrointestinal stromal tumour (GIST), most of them without an apparent family relationship; only 5% of them occur within the context of a family syndrome. In this article the corresponding literature about the former has been reviewed. A search in Pubmed was carried out, the methodology of which is described in detail in the body of the article. A total of 88 articles have been chosen for the review, next to the application of limits as well as a manual review. GIST patients have a twofold risk of developing a second tumour than the general population (4-33% of them develop a second neoplasm, either synchronic or metachronic)...
October 23, 2017: Medicina Clínica
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