keyword
MENU ▼
Read by QxMD icon Read
search

gastrointestinal stromal tumour

keyword
https://www.readbyqxmd.com/read/28208869/mature-cystic-teratoma-with-co-existent-mucinous-cystadenocarcinoma-in-the-same-ovary-a-diagnostic-dilemma
#1
Sanjeet Roy, Sramana Mukhopadhayay, Mayank Gupta, Anuradha Chandramohan
Mature cystic teratoma co-existing with a mucinous cystadenocarcinoma is an infrequently encountered entity with only a handful of cases reported till date. The possibilities in such a case are either a malignant transformation of a benign teratoma into adenocarcinoma or a collision tumor between a mature cystic teratoma and a mucinous tumour of either a primary ovarian surface epithelial-stromal origin or a secondary from a primary gastrointestinal tract tumour. The importance of distinguishing between the two entities has significant bearing on subsequent therapeutic management...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203166/gastrointestinal-stromal-tumour-with-synchronous-bone-metastases-a-case-report-and-literature-review
#2
Philippe Rochigneux, Lénaig Mescam-Mancini, Delphine Perrot, Erwan Bories, Laurence Moureau-Zabotto, Anthony Sarran, Jérôme Guiramand, François Bertucci
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28199021/successful-treatment-of-a-metastatic-gastrointestinal-stromal-tumour-in-a-dog-with-toceranib-phosphate-palladia
#3
J W Elliott, F Swinbourne, A Parry, L Baines
A ten-year-old, female-entire English springer spaniel presented with a large intra-abdominal mass but no other clinical signs. Gastrointestinal stromal tumour of the caecum with widespread abdominal metastasis was confirmed. Treatment with toceranib phosphate resulted in complete response, despite the absence of exon-8 or exon-11 c-kit mutation. There was no clinical evidence of tumour recurrence nine months after diagnosis.
February 15, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28170370/development-of-a-gene-panel-for-next-generation-sequencing-of-clinically-relevant-mutations-in-cell-free-dna-from-cancer-patients
#4
Umberto Malapelle, Clara Mayo de-Las-Casas, Danilo Rocco, Monica Garzon, Pasquale Pisapia, Nuria Jordana-Ariza, Maria Russo, Roberta Sgariglia, Caterina De Luca, Francesco Pepe, Alejandro Martinez-Bueno, Daniela Morales-Espinosa, María González-Cao, Niki Karachaliou, Santiago Viteri Ramirez, Claudio Bellevicine, Miguel Angel Molina-Vila, Rafael Rosell, Giancarlo Troncone
BACKGROUND: When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use in ultra-deep sequencing to identify such mutations in cfDNA. METHODS: Our panel ('SiRe') covers 568 mutations in six genes (EGFR, KRAS, NRAS, BRAF, cKIT and PDGFRα)involved in non-small-cell lung cancer (NSCLC), gastrointestinal stromal tumour, colorectal carcinoma and melanoma...
February 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28104721/gastrointestinal-stromal-tumour-gist-presenting-as-a-strangulated-inguinal-hernia-with-small-bowel-obstruction
#5
Marco Massani, Giovanni Capovilla, Cesare Ruffolo, Nicolò Bassi
Gastrointestinal stromal tumours (GISTs) can arise everywhere along the gastrointestinal (GI) tract. Their presentation in unusual locations should always be taken into account. A 74-year-old man referred to the emergency department for small bowel obstruction caused by an incarcerated inguinal hernia. A CT scan showed a mesenchymal tumour originating from the herniated bowel loop and a mass in the ascending colon. Laparoscopic resection of the mass and laparoscopic right hemicolectomy were performed. The histology showed a ruptured GIST arising from the herniated small bowel and a high-grade dysplasia villous adenoma of the right colon...
January 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28092014/a-rare-entity-of-gastrointestinal-stromal-tumour-arising-from-a-meckel-s-diverticulum-a-case-report
#6
Kshitij Manerikar, Iqbal Ali, Chandradip Patil, Mirat Dholakia, Pratham Mody
No abstract text is available yet for this article.
January 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28050383/unusual-visceral-sarcomas-report-of-2-cases-with-review-of-literature
#7
Navneet Jain, Nadia Shirazi, Neena Chauhan, Meenu Gupta
Sarcomas account for only 1% of adult solid tumours. Visceral sarcomas except Gastrointestinal Stromal Tumours (GIST) are rare and therefore little is known about the natural history and prognosis of these tumours. They tend to occur in older adults with no sex predilection and are characterized by an aggressive behaviour. Proper evaluation of these tumours is necessary because these are uncommon tumours which often present with advanced disease in an anatomically complex location. Since there are very few published studies on visceral sarcomas, the data is insufficient to suggest prognosis and optimum treatment strategies...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28000652/laparoscopic-resection-of-duodenal-gastrointestinal-stromal-tumour
#8
Tammy Zioni, Vitaliy Dizengof, Boris Kirshtein
Only a few studies have revealed using laparoscopic technique with limited resection of gastrointestinal stromal tumour (GIST) of the duodenum. A 68-year-old man was admitted to the hospital due to upper gastrointestinal (GI) bleeding. Evaluation revealed an ulcerated, bleeding GI tumour in the second part of the duodenum. After control of bleeding during gastroduodenoscopy, he underwent a laparoscopic wedge resection of the area. During 1.5 years of follow-up, the patient is disease free, eats drinks well, and has regained weight...
December 21, 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27999655/clinical-implications-of-repeated-drug-monitoring-of-imatinib-in-patients-with-metastatic-gastrointestinal-stromal-tumour
#9
Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist, Kjetil Boye
BACKGROUND: Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clinical outcomes in GIST patients. However, there are few studies of repeated measurements of IM levels, and therapeutic drug monitoring is not yet a part of routine clinical practice. This study was conducted to reveal clinical scenarios where plasma concentration measurement of IM trough level (Cmin) is advantageous...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27972562/cost-effectiveness-analysis-of-regorafenib-in-gastrointestinal-stromal-tumours-in-england-using-crossover-adjustment-methods
#10
A Pitcher, E Grabbi, M Madin-Warburton, S Vadgama
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27964865/gastrointestinal-stromal-tumours-gists-a-descriptive-study-on-29-cases
#11
Lamine Hamzaoui, Mouna Medhioub, Mahdi Bouassida, Moufida Mahmoudi, Souhaiel El Bouchtili, Heykal Ezzine, Emna Chelbi, Hassen Touinsi, Mohamed Mousadek Azouz
BACKGROUND AND STUDY AIM: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, originating from Cajal cells in different sites of the digestive tract. The aim of the study is to report on epidemiological, clinical, histological, and therapeutic characteristics of GISTs. PATIENTS AND METHODS: A retrospective descriptive study of 29 cases of GIST in gastroenterology and general surgery departments of Mohamed Tahar Maamouri Hospital (Nabeul, Tunisia) was conducted from January 2005 to March 2012...
December 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27904782/prognostic-values-of-dlk1-for-surgery-and-imatinib-mesylate-adjuvant-therapy-in-gastrointestinal-stromal-tumors
#12
Jia Xu, Ming Wang, Zizhen Zhang, Wenyi Zhao, Chaojie Wang, Lin Tu, Yeqian Zhang, Hui Cao
The Delta-like 1 homolog (DLK1) gene is a paternal imprinting gene located on human chromosome 14q32, a site associated with frequent chromosomal mutations in GIST. The expression level of DLK1 is closely associated with the outcome of tumours. However, no study has reported the DLK1 expression in GIST. Here, we demonstrated that DLK1 showed low expression in GIST patients with low risk according to the modified National Institute of Health (NIH) criteria. With increasing tumour risk level, DLK1 gene and protein expression levels gradually increased...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27900093/primary-gastrointestinal-stromal-tumour-of-the-ileum-pre-operatively-diagnosed-as-an-abdominal-abscess
#13
Patrizia Rubini, Francesco Tartamella
The present case report described the acute presentation, diagnosis and management of a primary gastrointestinal stromal tumour (GIST) of the ileum. A male patient (age, 51 years) was admitted to Maggiore Hospital (Parma, Italy) due to presenting with fever, dysuria and lower abdominal pain. Ultrasonography and computed tomography showed a 7,5×5,5-cm pelvic mass containing air and purulent fluid indicative of an intraperitoneal abscess. The patient was subjected to diagnostic laparoscopy, which revealed a huge, soft cystic mass arising from the small bowel...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27886554/a-biomaterial-assisted-mesenchymal-stromal-cell-therapy-alleviates-colonic-radiation-induced-damage
#14
Lara Moussa, Girish Pattappa, Bastien Doix, Sarra-Louiza Benselama, Christelle Demarquay, Marc Benderitter, Alexandra Sémont, Radia Tamarat, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Noëlle Mathieu
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy to reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able to encapsulate and withstand Ad-MSCs, can overcome these limitations. A silanized hydroxypropylmethyl cellulose (Si-HPMC) hydrogel has been designed and characterized for injectable cell delivery using the operative catheter of a colonoscope...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27855991/-obscure-gastrointestinal-bleeding-due-to-gastrointestinal-stromal-tumors
#15
Larry Romero-Espinosa, Luis Manuel Souza-Gallardo, José Luis Martínez-Ordaz, Teodoro Romero-Hernández, Mauricio de la Fuente-Lira, Jorge Arellano-Sotelo
BACKGROUND: The gastrointestinal stromal tumours (GIST) are the most common soft tissue sarcomas of the digestive tract. They are usually found in the stomach (60-70%) and small intestine (25-30%) and, less commonly, in the oesophagus, mesentery, colon, or rectum. The symptoms present at diagnosis are, gastrointestinal bleeding, abdominal pain, abdominal mass, or intestinal obstruction. The type of symptomatology will depend on the location and size of the tumour. The definitive diagnosis is histopathological, with 95% of the tumours being positive for CD117...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27847538/gastrointestinal-stromal-tumour-of-the-stomach-in-an-8-year-old-boy
#16
James Dc Coates
We report a case of an 8-year-old boy who underwent an ultrasound for investigation of a left upper quadrant mass and who was subsequently diagnosed with gastrointestinal stromal tumour of his stomach. Abdominal ultrasound showed a large cystic mass in the left upper abdomen which was further characterised by magnetic resonance imaging. At laparotomy, a large cystic lesion was excised from his stomach, which was confirmed at histology to be a gastrointestinal stromal tumour. We briefly discuss the presentation and imaging findings of paediatric gastrointestinal stromal tumour and how it differs from the adult form of the disease and treatments...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27844452/urgency-surgical-treatment-for-duodenal-gists-analysis-of-aged-patients-and-review-of-the-literature
#17
Carlo Boselli, Roberto Cirocchi, Alessandro Gemini, Francesco Barberini, Veronica Grassi, Stefano Avenia, Andrea Polistena, Alessandro Sanguinetti, Daniele Pironi, Alberto Santoro, Renata Tabola, Nicola Avenia
INTRODUCTION: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms (85%) of the gastrointestinal (GI) tract; duodenal GISTs constitute 3-5% of all GISTs and represent 10-30% of all malignant tumours of the duodenum. Rarely, patients present severe bowel obstruction, perforation or severe bleeding. The radical resection with complete removal of the tumour remains the main therapeutic approach. We performed a local resection in patients with suspected GIST admitted for emergency treatment for GI bleeding...
November 14, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27843616/update-on-clinical-research-and-state-of-the-art-management-of-patients-with-advanced-sarcomas-and-gist
#18
REVIEW
Yannis Metaxas, Georgios Oikonomopoulos, George Pentheroudakis
Sarcomas constitute a rare group of malignancies. According to histology, different treatment options are effective. For gastrointestinal stromal tumours (GISTs), targeted treatment with imatinib controls about 20% of advanced or metastatic disease, whereas chemotherapy is more effective for the rest of the sarcomas. Currently, new targeted treatments are emerging, showing activity in cases resistant to established primary treatment. On the other hand, the exciting results of immunotherapy for other solid tumours, for example, melanoma and lung cancer, make it a promising option in the fight against sarcomas...
2016: ESMO Open
https://www.readbyqxmd.com/read/27843612/tki-induced-pure-red-cell-aplasia-first-case-report-of-pure-red-cell-aplasia-with-both-imatinib-and-nilotinib
#19
Bishesh Sharma Poudyal, Sampurna Tuladhar, Bishal Gyawali
Tyrosine-kinase inhibitors (TKIs) represent the only hopes for long-term survival for patients with chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours. Thus, uninterrupted use of TKIs is of importance in such patients. Pure red cell aplasia (PRCA) is a rare disorder, not previously known to be associated with TKIs. We present, to the best of our knowledge, the first case of a patient with CML who developed PRCA secondary to both imatinib and nilotinib. Although PRCA was controlled on withdrawal of TKI, TKI continuation in the patient with CML is important...
2016: ESMO Open
https://www.readbyqxmd.com/read/27773150/dual-diagnosis-of-gastrointestinal-stromal-tumour-and-papillary-renal-cell-carcinoma-by-upper-gastrointestinal-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-a-case-report
#20
keyword
keyword
37705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"