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https://www.readbyqxmd.com/read/29331217/the-cost-of-perioperative-complications-following-pancreaticoduodenectomy-a-systematic-review
#1
REVIEW
Jason Wang, Ronald Ma, Leonid Churilov, Paul Eleftheriou, Mehrdad Nikfarjam, Christopher Christophi, Laurence Weinberg
BACKGROUND/OBJECTIVES: Pancreaticoduodenectomy (PD), also known as a Whipple procedure, is commonly performed for a variety of benign and malignant tumours, including of the pancreatic head and surrounding structures. PD is associated with low mortality but high morbidity and costs. Our objective was to describe the financial burden of complications following pancreaticoduodenectomy. METHODS: We searched for articles using the MEDLINE, EMBASE, Cochrane and EconLit databases from the year 2000...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29329392/risk-of-pancreatic-cancer-associated-with-family-history-of-cancer-and-other-medical-conditions-by-accounting-for-smoking-among-relatives
#2
E Molina-Montes, P Gomez-Rubio, M Márquez, M Rava, M Löhr, C W Michalski, X Molero, A Farré, J Perea, W Greenhalf, L Ilzarbe, M O'Rorke, A Tardón, T Gress, V M Barberà, T Crnogorac-Jurcevic, E Domínguez-Muñoz, L Muñoz-Bellvís, J Balsells, E Costello, J Huang, M Iglesias, J Kleeff, Bo Kong, J Mora, L Murray, D O'Driscoll, I Poves, A Scarpa, W Ye, M Hidalgo, L Sharp, A Carrato, F X Real, N Malats
Background: Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk of PC, but little is known regarding the role of inherited/environmental factors or that of FH of other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches. Methods: Case-control study including 1431 PC cases and 1090 controls and a reconstructed-cohort study (N = 16 747) made up of their first-degree relatives (FDR)...
January 10, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29328761/pancreatic-cancer-a-symptomless-killer
#3
Karen Gedge
Pancreatic cancer is the fifth most common cause of cancer death in the UK. This disease often remains undiagnosed until it is at a late stage, resulting in the majority of tumours being unsuitable for surgical resection. When a diagnosis of pancreatic cancer is confirmed, early input from the multi-disciplinary team (MDT) is vital. Due to the poor prognosis, the screening and treatment of pancreatic cancer remains a considerable challenge for medicine in the 21st century.
July 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29328401/long-non-coding-rna-meg3-functions-as-a-tumour-suppressor-and-has-prognostic-predictive-value-in-human-pancreatic-cancer
#4
Ling Ma, Feng Wang, Chong Du, Zhengkui Zhang, Huahu Guo, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Xiaodong Tian, Yinmo Yang
Long non-coding RNA (lncRNA) MEG3 has been demonstrated to be a tumour suppressor in many malignancies. However, the functional role of MEG3 in pancreatic cancer (PC) is unclear. In this study, the expression pattern of MEG3 was evaluated in 25 samples of microdissected PC tissues and 8 PC cell lines and was compared to the expression in adjacent non‑cancerous tissues and a human pancreatic normal epithelial cell line. Loss of MEG3 expression was observed in both the cancerous tissues and cancer cell lines...
January 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29322792/krasg12d-loh-promotes-malignant-biological-behavior-and-energy-metabolism-of-pancreatic-ductal-adenocarcinoma-cells-through-the-mtor-signaling-pathway
#5
X Shen, L G Chang, M Y Hu, D Yan, L N Zhou, Y Ma, S K Ling, Y Q Fu, S Y Zhang, B Kong, P L Huang
Oncogenic Kras with loss of heterozygosity (LOH) is frequently detected in various tumours. However, the exact function and mechanism by which KrasG12D-LOH operates remain unclear. Therefore, the current study investigated the effect of KrasG12D-LOH on the malignant phenotype of pancreatic ductal adenocarcinoma (PDAC) cells. Our investigation revealed that KrasG12D-LOH is associated with increased proliferation, invasion and reduced apoptosis in PDAC cells. The results also exhibited enhanced glycolytic phenotype of KrasG12D-LOH PDAC cells...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322406/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-preclinical-evaluation-of-therapies-in-cancer
#6
William Berry, Daniel Croagh
Personalising cancer therapy is a way of improving treatment efficacy, by selecting specific treatments for patients with certain molecular changes to their tumour. This requires both molecular material to detect these targets and a preclinical disease model to demonstrate treatment efficacy. In pancreatic cancer this is problematic, as most patients present with advanced disease and are therefore ineligible for surgery. As a result, biological material derived from such patients has been excluded from all preclinical studies in personalised medicine...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321190/genomic-landscape-of-pancreatic-neuroendocrine-tumours-the-international-cancer-genome-consortium
#7
Andrea Mafficini, Aldo Scarpa
Neuroendocrine tumours (NETs) may arise throughout the body and are a highly heterogeneous, relatively rare class of neoplasms difficult to study also for the lack of disease models. Despite this, knowledge on their molecular alterations has expanded in the latest years, also building from genetic syndromes causing their onset. Pancreatic NETs (PanNETs) have been among the most studied, and research so far has outlined a series of recurring features, as inactivation of MEN1, VHL, TSC1/2 genes, and hyperactivation of the PI3K/mTOR pathway...
January 10, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29316343/circulating-monocyte-chemoattractant-protein-1-mcp-1-is-associated-with-cachexia-in-treatment-na%C3%A3-ve-pancreatic-cancer-patients
#8
Erin E Talbert, Heather L Lewis, Matthew R Farren, Mitchell L Ramsey, Jeffery M Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M Pawlik, Teresa A Zimmers, Gregory B Lesinski, Phil A Hart, Mary E Dillhoff, Carl R Schmidt, Denis C Guttridge
BACKGROUND: Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. Thus, we sought to assess potential biomarkers of cancer-induced cachexia in patients with earlier stages of disease...
January 7, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29316119/solid-pseudopapillary-tumour-of-the-pancreas-clinicopathological-analysis
#9
Simon McCluney, Nilukshi Wijesuriya, Vinayata Sheshappanavar, Joanne Chin-Aleong, Roger Feakins, Robert Hutchins, Ajit Abraham, Satyajit Bhattacharya, Roberto Valente, Hemant Kocher
BACKGROUND: We report on our experience of the surgical management and outcomes of 11 patients with solid pseudopapillary tumour of the pancreas (SPT). We sought to correlate the immunohistochemical staining of these tumours with that previously reported in the literature. METHODS: A retrospective analysis of the clinical presentation, radiological findings, surgical treatment, histopathological characteristics and outcomes for patients surgically managed with SPT at The Royal London Hospital...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29288273/pro-inflammatory-cytokines-after-an-episode-of-acute-pancreatitis-associations-with-fasting-gut-hormone-profile
#10
Sayali A Pendharkar, Ruma G Singh, Shayal K Chand, Aya Cervantes, Maxim S Petrov
INTRODUCTION: Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are often elevated in individuals after acute pancreatitis but what determines their levels is poorly understood. Gut hormones have emerged as possible modulators of inflammatory response. The aim was to investigate the associations between pro-inflammatory cytokines and a comprehensive panel of gut hormones after an episode of acute pancreatitis...
December 29, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29285254/microrna-co-expression-networks-exhibit-increased-complexity-in-pancreatic-ductal-compared-to-vater-s-papilla-adenocarcinoma
#11
Tommaso Mazza, Massimiliano Copetti, Daniele Capocefalo, Caterina Fusilli, Tommaso Biagini, Massimo Carella, Antonio De Bonis, Nicola Mastrodonato, Ada Piepoli, Valerio Pazienza, Evaristo Maiello, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli, Francesca Tavano
MiRNA expression abnormalities in adenocarcinoma arising from pancreatic ductal system (PDAC) and Vater's papilla (PVAC) could be associated with distinctive pathologic features and clinical cancer behaviours. Our previous miRNA expression profiling data on PDAC (n=9) and PVAC (n=4) were revaluated to define differences/similarities in miRNA expression patterns. Afterwards, in order to uncover target genes and core signalling pathways regulated by specific miRNAs in these two tumour entities, miRNA interaction networks were wired for each tumour entity, and experimentally validated target genes underwent pathways enrichment analysis...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282264/comparing-the-diagnostic-accuracy-of-five-common-tumour-biomarkers-and-ca19-9-for-pancreatic-cancer-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#12
Long Ge, Bei Pan, Fujian Song, Jichun Ma, Dena Zeraatkar, Jianguo Zhou, Jinhui Tian
INTRODUCTION: Surgical resection is the only curative treatment for patients with resectable pancreatic cancer. Unfortunately, 80%-85% of patients present with locally advanced or metastatic unresectable pancreatic cancer at the time of diagnosis. Detection of pancreatic cancer at early stages remains a great challenge due to lack of accurate detection tests. Recommendations in existing clinical practice guidelines on early diagnosis of pancreatic cancer are inconsistent and based on limited evidence...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29277891/fluorescence-and-multispectral-optoacoustic-imaging-for-an-optimised-detection-of-deeply-located-tumours-in-an-orthotopic-mouse-model-of-pancreatic-carcinoma
#13
Joanna Napp, Marieke A Stammes, Jing Claussen, Hendrica A J M Prevoo, Cornelis F M Sier, Freek J M Hoeben, Marc S Robillard, Alexander L Vahrmeijer, Tim Devling, Alan B Chan, Lioe-Fee de Geus-Oei, Frauke Alves
A crucial point for the management of pancreatic ductal adenocarcinoma (PDAC) is the decrease of R1 resections. Our aim was to evaluate the combination of multispectral optoacoustic tomography (MSOT) with fluorescence guided surgery (FGS) for diagnosis and perioperative detection of tumour nodules and resection margins in a xenotransplant mouse model of human pancreatic cancer. The peptide cRGD, conjugated with the near infrared fluorescent (NIRF) dye IRDye800CW and with a trans-cyclooctene (TCO) tag for future click chemistry (cRGD-800CW-TCO), was applied to PDAC bearing immunodeficient nude mice...
December 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29273939/impact-of-tissue-transport-on-pet-hypoxia-quantification-in-pancreatic-tumours
#14
Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C Dhani, Iram Siddiqui, David W Hedley, David A Jaffray
BACKGROUND: The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive PET tracers is slow, comparable to the rate of diffusive equilibration in some tissue types, including mucinous and necrotic tissue. This means that tracer uptake on the scale of a PET imaging voxel-large enough to include such tissue and hypoxic cells-can be as much determined by tissue transport properties as it is by hypoxia...
December 22, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29258858/emerging-biomarkers-for-immunomodulatory-cancer-treatment-of-upper-gastrointestinal-pancreatic-and-hepatic-cancers
#15
REVIEW
Belinda Lee, Ryan Hutchinson, Hui-Li Wong, Jeanne Tie, Tracy Putoczki, Ben Tran, Peter Gibbs, Michael Christie
Carcinomas of the oesophagus, stomach, pancreas and liver are common and account for a disproportionately high number of cancer deaths. There is a need for new treatment options for patients with advanced disease. Immunomodulatory treatments including immune checkpoint blockade offer a promising new approach, with efficacy shown in other solid tumour types. However, only a small proportion of patients with carcinomas of the oesophagus, stomach, pancreas and liver have responded to single agent checkpoint inhibitors, and there is a need for markers that are predictive of response to guide treatment of individual patients...
December 16, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29250314/a-case-of-long-survival-insulinoma-with-multiple-neuroendocline-tumour-type-1-controlled-by-multimodal-therapy
#16
Masahiro Shiihara, Wataru Izumo, Ryota Higuchi, Takehisa Yazawa, Shuichiro Uemura, Toru Furukawa, Masakazu Yamamoto
Insulinomas with multiple neuroendocrine tumour type 1 (MEN1) sometimes have metachronous or recurrent tumours. However, the treatment for these tumours is controversial, and published reports regarding multimodal therapy for insulinomas are limited. We report a 73-year-old woman with recurrent insulinoma with MEN1 successfully controlled by multimodal therapy. She had several complications, and poor performance status. Her hypoglycaemia did not improve after 6-month octreotide LAR; as such, she underwent enucleation of the pancreatic tumour...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29241949/a-severe-but-reversible-reduction-in-insulin-sensitivity-is-observed-in-patients-with-insulinoma
#17
Raluca Maria Furnica, Laure Istasse, Dominique Maiter
BACKGROUND: Hypoglycemic manifestations are highly variable in patients with an insulinoma and largely independent of tumour size and severity of insulin hypersecretion. OBJECTIVES: We investigated the clinical, biological and tumoral characteristics of insulinomas in a large monocentric series of patients and we evaluated their insulin sensitivity before and after successful pancreatic surgery. PATIENTS AND METHODS: This was a retrospective analysis of 40 patients treated for an insulinoma between 1982 and 2012 in our academic hospital...
December 11, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29239038/gastroenteropancreatic-neuroendocrine-neoplasms-selected-pathology-review-and-molecular-updates
#18
REVIEW
Siaw M Chai, Ian S Brown, M Priyanthi Kumarasinghe
Gastroenteropancreatic (GEP) neuroendocrine neoplasms can be broadly separated into well- and poorly differentiated categories. Tumours within each category have similarities in morphology and immunophenotype, but vary in grade, behaviour, molecular signature and responses to therapy. The aetiology of these differences is multifactorial. Site of origin, mucosal milieu and hereditary influences are some of the currently known factors. Given these differences, staging and grading systems continue to evolve, and the most recent World Health Organization classification of pancreatic neuroendocrine neoplasms reflects this by introducing a grade 3 neuroendocrine tumour category for morphologically well-differentiated tumours with an elevated Ki-67 proliferation index and/or mitotic count...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239037/well-differentiated-pancreatic-neuroendocrine-tumours-pannets-and-poorly-differentiated-pancreatic-neuroendocrine-carcinomas-pannecs-concepts-issues-and-a-practical-diagnostic-approach-to-high-grade-g3-cases
#19
REVIEW
Aatur D Singhi, David S Klimstra
With increasing accessibility and advancements in abdominal imaging modalities, the incidence of pancreatic neuroendocrine neoplasms has increased steadily during the past few decades. By definition, neuroendocrine neoplasms of the pancreas show neuroendocrine differentiation, but they represent a broad and heterogeneous group of neoplasms with diverse clinical and pathological characteristics. The majority of pancreatic neuroendocrine neoplasms can be classified as well-differentiated pancreatic neuroendocrine tumours (PanNETs) or poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs)...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29235373/pro-inflammatory-cytokine-induced-lipolysis-after-an-episode-of-acute-pancreatitis
#20
Sayali A Pendharkar, Ruma G Singh, Maxim S Petrov
CONTEXT: Pro-inflammatory cytokine-stimulated lipolysis is one of the mechanisms underlying the pathogenesis of type 2 diabetes. However, whether it plays a role in the pathogenesis of post-pancreatitis diabetes mellitus (PPDM) remains unknown. OBJECTIVE: To investigate the associations between markers of lipid metabolism and pro-inflammatory cytokines in individuals after acute pancreatitis (AP) in general, and in individuals with abnormal glucose metabolism (AGM) following AP in particular...
December 13, 2017: Archives of Physiology and Biochemistry
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