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https://www.readbyqxmd.com/read/29770894/efficacy-of-punarnavine-in-restraining-organ-specific-tumour-progression-in-4t1-induced-murine-breast-tumour-model
#1
Gilcy George Kallivalappil, Girija Kuttan
Most of the breast cancer deaths occur when cancer cells depart from their tumour of origin and spread systemically and colonise distant organs. The present study was to find out whether punarnavine, the quinolizidine alkaloid, with already proven antimetastatic effect on spontaneous B16F10 pulmonary metastasis has got any effect on a drastic organ-specific breast cancer spread. For the study, we selected a syngenic mouse 4T1 breast tumour model that mimics stage four of human breast cancer. The metastatic progression of 4T1 to lymph nodes, lungs, and liver was reduced by punarnavine (40 mg/kg body weight) administration in BALB/c mice...
May 17, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29761918/lncrna-hoxa11-as-promotes-hepatocellular-carcinoma-progression-by-repressing-mir-214-3p
#2
Meixiao Zhan, Ke He, Jing Xiao, Fei Liu, Haihe Wang, Zhenglin Xia, Xiaopeng Duan, Rui Huang, Yong Li, Xu He, Hua Yin, Guoan Xiang, Ligong Lu
Accumulating studies supported that lncRNAs played important roles in tumorigenesis. LncRNA HOXA11-AS was a novel lncRNA that has been proved to involved in several tumours. However, the role of HOXA11-AS in the development of hepatocellular carcinoma (HCC) remains to be explained. In our study, we showed that HOXA11-AS expression was up-regulated in the HCC tissues, and the higher expression of HOXA11-AS was associated with the advanced stage in the HCC samples. In addition, we indicated that the expression of HOXA11-AS was up-regulated in HCC cell lines (Hep3B, SMMC-7721, MHCC97-H and BEL-7402) compared with normal liver cell lines (HL-7702)...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29755775/rectal-and-anal-canal-neuroendocrine-tumours
#3
Teresa Raposo André, Margarida Brito, João Geraldes Freire, António Moreira
Neuroendocrine tumors (NETs) are rare, representing 0.5% of all newly diagnosed malignancies. Rectal and anal canal (AC) NETs account for less than 1% of all rectal and AC cancers. Review our institutional experience on NET of the rectum and AC, with emphasis on demographic, histological and treatment features and oncologic outcomes. The study group was identified from the Portuguese Regional South Oncological Registry. From 2000 to 2014, 22 patients with rectal or AC NETs were treated at our institution. Medical records were retrospectively reviewed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755635/microfluidic-platform-for-probing-cancer-cells-migration-property-under-periodic-mechanical-confinement
#4
Dongce Ma, Ran Wang, Shuxun Chen, Tao Luo, Yu-Ting Chow, Dong Sun
Cancer cell migration and invasion, which are involved in tumour metastasis, are hard to predict and control. Numerous studies have demonstrated that physical cues influence cancer cell migration and affect tumour metastasis. In this study, we proposed the use of a microchannel chip equipped with a number of vertical constrictions to produce periodic compression forces on cells passing through narrow channels. The chip with repeated vertical confinement was applied on adherent MHCC-97L liver cancer cells and suspended OCI-AML leukaemia cells to determine the migration ability of these cancer cells...
March 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29754133/solitary-calvarial-haemangioma-presenting-as-metastatic-renal-cell-carcinoma
#5
Calver Pang, Yew Loong Loo, Robert Corns, Rasheed Mohammed
Renal cell carcinoma is the most common renal tumour in adult that often metastasises to the lung, liver or bone. Head and neck lesions are uncommon with no early warning signs and presents with overt metastases at primary presentation in 25%-30% of reported cases. The incidence of haemangiomas that suggest malignancy are similar to that of bone metastasis. Calvarial haemangiomas usually present as asymptomatic and discovered incidentally on imaging or postmortem examination. We report a case where an initial diagnosis of benign tumour of the skull was made based on clinical presentation and calvarial haemangioma on CT head but was confirmed as metastatic clear cell carcinoma of the kidney after histopathological results...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29748642/gestational-oral-low-dose-estradiol-17%C3%AE-induces-altered-dna-methylation-of-cdkn2d-and-psat1-in-embryos-and-adult-offspring
#6
Vera A van der Weijden, Veronika L Flöter, Susanne E Ulbrich
Endocrine disrupting chemicals (EDC) interfere with the natural hormone balance and may induce epigenetic changes through exposure during sensitive periods of development. In this study, the effects of short-term estradiol-17β (E2) exposure on various tissues of pregnant sows (F0 ) and on day 10 blastocysts (F1 ) were assessed. Intergenerational effects were investigated in the liver of 1-year old female offspring (F1 ). During gestation, sows were orally exposed to two low doses and a high dose of E2 (0.05, 10, and 1000 µg/kg body weight/day)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741394/effective-combination-therapy-of-percutaneous-ethanol-injection-and-chemotherapy-based-on-injectable-low-molecular-weight-gels
#7
Guotao Li, Yan Liang, Changzhen Sun, Xinyu Peng, Na Hao, Miaochang Liu, Wenxia Gao, Huayue Wu, Bin He
Percutaneous ethanol injection (PEI) therapy was used in liver cancer treatment, however, the therapeutic ethanol in PEI easily flew away from injected solid tumours and hinder the treatment effect. In this paper, injectable supramolecular gels formed by self-assembly of low molecular weight gelators (LMWGs) based on glycylglycine modified phenylboronic acid were prepared to localize ethanol and load chemotherapeutic drug for in situ synergistic therapy. The mechanism, morphology and rheological property of supramolecular gels were characterized by NMR, UV, SEM, etc...
May 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29740688/the-safety-and-efficacy-of-oxycodone-versus-fentanyl-in-percutaneous-microwave-ablation-of-a-liver-tumour-abutting-the-capsule
#8
Wen-Tao Wu, Zhen-Yu Jia, Yu Chen, Qi-Feng Chen, Qing-Quan Zu, Zheng-Qiang Yang, Sheng Liu, Hai-Bin Shi
PURPOSE: The present study compared the safety and efficacy of oxycodone with those of fentanyl under non-intubated general anaesthesia in percutaneous microwave ablation (MWA) of a liver tumour abutting the capsule. MATERIALS AND METHODS: Thirty-eight patients underwent MWA of liver cancers abutting the capsule. Patients received 0.1 mg/kg oxycodone (O group) or 1 μg/kg fentanyl (F group) prior to the start of ablation. Both groups received continuous infusions of propofol for non-intubated general anaesthesia during ablation...
May 8, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29740687/radioembolisation-in-europe-a-survey-amongst-cirse-members
#9
Margot T M Reinders, Etienne Mees, Maciej J Powerski, Rutger C G Bruijnen, Maurice A A J van den Bosch, Marnix G E H Lam, Maarten L J Smits
INTRODUCTION: Radioembolisation of liver tumours demands many choices from the physician regarding planning of treatment and subsequent follow-up. METHODS: An online questionnaire was distributed amongst all members of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) to investigate the current state of radioembolisation practice. RESULTS: The survey was completed by 60 centres. The increasing number of radioembolisation procedures may reflect that radioembolisation is increasingly recognised as a valuable treatment option in European cancer guidelines...
May 8, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#10
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29737513/development-and-validation-of-a-difficulty-score-to-predict-intraoperative-complications-during-laparoscopic-liver-resection
#11
M C Halls, G Berardi, F Cipriani, L Barkhatov, P Lainas, S Harris, M D'Hondt, F Rotellar, I Dagher, L Aldrighetti, R I Troisi, B Edwin, M Abu Hilal
BACKGROUND: Previous studies have demonstrated that patient, surgical, tumour and operative variables affect the complexity of laparoscopic liver resections. However, current difficulty scoring systems address only tumour factors. The aim of this study was to develop and validate a predictive model for the risk of intraoperative complications during laparoscopic liver resections. METHODS: The prospectively maintained databases of seven European tertiary referral liver centres were compiled...
May 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29737459/safety-of-intra-articular-transplantation-of-lentivirally-transduced-mesenchymal-stromal-cells-for-haemophilic-arthropathy-in-a-non-human-primate
#12
Tsukasa Ohmori, Hiroaki Mizukami, Yuko Katakai, Sho Kawai, Hitoyasu Nakamura, Makoto Inoue, Tsugumine Shu, Hideharu Sugimoto, Yoichi Sakata
Joint bleeding and resultant arthropathy are major determinants of quality of life in haemophilia patients. We previously developed a mesenchymal stromal cell (MSC)-based treatment approach for haemophilic arthropathy in a mouse model of haemophilia A. Here, we evaluated the long-term safety of intra-articular injection of lentivirally transduced autologous MSCs in non-human primates. Autologous bone-marrow-derived MSCs transduced with a lentiviral vector expressing coagulation factor VIII (FVIII) were injected into the left knee joint of cynomolgus monkeys...
May 8, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29736801/global-rigid-registration-of-ct-to-video-in-laparoscopic-liver-surgery
#13
Maria R Robu, João Ramalhinho, Stephen Thompson, Kurinchi Gurusamy, Brian Davidson, David Hawkes, Danail Stoyanov, Matthew J Clarkson
PURPOSE: Image-guidance systems have the potential to aid in laparoscopic interventions by providing sub-surface structure information and tumour localisation. The registration of a preoperative 3D image with the intraoperative laparoscopic video feed is an important component of image guidance, which should be fast, robust and cause minimal disruption to the surgical procedure. Most methods for rigid and non-rigid registration require a good initial alignment. However, in most research systems for abdominal surgery, the user has to manually rotate and translate the models, which is usually difficult to perform quickly and intuitively...
May 7, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29726404/feasibility-study-of-fe-sub-3-sub-o-sub-4-sub-tao-sub-x-sub-nanoparticles-as-a-radiosensitizer-for-proton-therapy
#14
Sang Hee Ahn, Nohyun Lee, Changhoon Choi, Sung Won Shin, Youngyih Han, Hee Chul Park
We investigated the feasibility of using multifunctional Fe3O4/TaOx (core/shell) nanoparticles, developed for use in contrast agents for computed tomography (CT) and magnetic resonance imaging (MRI), as dose-enhancing radiosensitizers. First, to verify the detectability of Fe3O4/TaOx nanoparticles in imaging, in vivo tests were conducted. Approximately 600 mg/kg of 19-nm-diameter Fe3O4/TaOx nanoparticles dispersed in phosphate-buffered saline was injected into the tail vein of six Balb/c mice used as tumour (4T1 mammary carcinoma cell) models...
May 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29726259/-liver-surgery-for-colorectal-liver-metastases
#15
V Třeška
INTRODUCTION: Resection of colorectal liver metastases (CLM) is the only radical treatment. Nevertheless, radical liver surgery for CLM is possible in about 30% of patients with 40-50% five year overall survival. The results of liver surgery depend on various factors including the extent of CLM, characteristics of the primary colorectal carcinoma, exact preoperative diagnosis and optimal timing of the surgery by a multidisciplinary team. The aim of this review is to summarize the current possibilities of liver surgery and to point out the possibilities of increasing resectability of primary non-resectable CLM...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29725020/hcc-derived-exosomes-elicit-hcc-progression-and-recurrence-by-epithelial-mesenchymal-transition-through-mapk-erk-signalling-pathway
#16
Lu Chen, Piao Guo, Yuchao He, Ziye Chen, Liwei Chen, Yi Luo, Lisha Qi, Yuanyuan Liu, Qiang Wu, Yunlong Cui, Feng Fang, Xiaofang Zhang, Tianqiang Song, Hua Guo
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhibiting metastasis and recurrence are urgently needed. Exosomes are small lipid-bilayer vesicles that are implicated in tumour development and metastasis. Rab27a, a small GTPase, regulates exosome secretion by mediating multivesicular endosome docking at the plasma membrane...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29724794/prognostic-value-of-chromogranin-a-in-patients-with-get-nen-in-the-pancreas-and-the-small-intestine
#17
Malgorzata Fuksiewicz, Maria Kowalska, Agnieska Kolasinska-Cwikla, Jaroslaw B Cwikla, Lukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, Beata Kotowicz
The aim of this study was to evaluate the clinical usefulness of the chromogranin A determination in patients with NENs of the digestive system and to analyse the association between concentration of the marker and PFS and OS. Serum concentrations of CgA were determined before the treatment in 131 patients with NENs, including patients with tumours located in the pancreas, the small intestine, caecum, appendix and in the colon. No significant associations were identified in CgA concentrations between the control group and patients with NENs in appendix and colon...
May 3, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29724434/visual-criterion-for-evaluating-hepatobiliary-phase-image-acquisition-of-gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid-enhanced-mri
#18
Y Takatsu, M Nakamura, S Kobayashi, T Miyati
AIM: To evaluate the hepatobiliary phase (HBP) of liver magnetic resonance imaging (MRI) using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid, and report a visual criterion based on the portal vein (PV), which can be used as a substitute for the quantitative liver-spleen contrast ratio (Q-LSC). MATERIALS AND METHODS: In HBP images of 167 patients, a visual criterion was established based on the sufficient contrast between the liver parenchyma (LP) and PV...
April 30, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29722201/treating-cachexia-using-soluble-acvr2b-improves-survival-alters-mtor-localization-and-attenuates-liver-and-spleen-responses
#19
Tuuli A Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J Hulmi
BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. METHODS: The effects of blocking activin receptor type 2 (ACVR2) ligands on both muscle and non-muscle tissues were investigated in a preclinical model of cancer cachexia using a recombinant soluble ACVR2B (sACVR2B-Fc). Treatment with sACVR2B-Fc was applied either only before the tumour formation or with continued treatment both before and after tumour formation...
May 2, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29720474/functional-and-genomic-characterization-of-a-xenograft-model-system-for-the-study-of-metastasis-in-triple-negative-breast-cancer
#20
Cameron N Johnstone, Andrew D Pattison, Kylie L Gorringe, Paul F Harrison, David R Powell, Peter Lock, David Baloyan, M Ernst, Alastair G Stewart, Traude H Beilharz, Robin L Anderson
Triple-negative breast cancer represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes. Hence, new molecular targets for therapeutic intervention are necessary. Analyses of panels of human or mouse cancer lines derived from the same individual that differ in their cellular phenotypes but not in genetic background have been instrumental in defining the molecular players that drive the various hallmarks of cancer.To determine the molecular regulators of metastasis in triple-negative breast cancer, we completed a rigorous in vitro and in vivo characterization of four populations of the MDA-MB-231 human breast cancer line ranging in aggressiveness from non-metastatic to spontaneously metastatic to lung, liver, spleen and lymph node...
April 30, 2018: Disease Models & Mechanisms
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