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https://www.readbyqxmd.com/read/28733679/increased-overall-cortical-connectivity-with-syndrome-specific-local-decreases-suggested-by-atypical-sleep-eeg-synchronization-in-williams-syndrome
#1
Ferenc Gombos, Róbert Bódizs, Ilona Kovács
Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams syndrome and 21 typically developing age- and gender-matched subjects by calculating weighted phase lag indexes. We found broadband increases in inter- and intrahemispheric neural connectivity for both NREM and REM sleep EEG of Williams syndrome subjects...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733188/assay-stability-the-missing-component-of-the-error-budget
#2
Mackay Mark, Hegedus Gabe, Badrick Tony
Gaining a better understanding of Quality Control (QC) processes is a key requirement to improving performance and reducing patient risk. Detecting analytical error is dependent on a QC strategy that reliably detects a critical shift in a result away from the true value. Recently the concept of Six Sigma has been used by diagnostic laboratories to assess the performance of assays and to assist in the selection of QC rules. The sigma metric is one measure of an assay's ability to perform within specification...
July 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28729683/a-positive-feedback-loop-mediated-by-sigma-x-enhances-expression-of-the-streptococcal-regulator-comr
#3
Rabia Khan, Roger Junges, Heidi A Åmdal, Tsute Chen, Donald A Morrison, Fernanda C Petersen
Natural transformation is used by bacteria to take up DNA from their surroundings and incorporate it into their genomes. Streptococci do so during a transient period of competence, triggered by pheromones that they produce, secrete and sense under conditions influenced by the environment. In Streptococcus mutans, Streptococcus suis, and species of the bovis, salivarius and pyogenic groups of streptococci, the pheromone XIP is sensed by the intra-cellular regulator ComR, that in turn activates the transcription of comS, encoding the XIP precursor, and of sigX, encoding the only known alternative sigma factor in streptococci...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729423/protection-of-the-general-stress-response-%C3%AF-s-by-crsr-allows-a-rapid-and-efficient-adaptation-of-shewanella-oneidensis
#4
Sophie Bouillet, Olivier Genest, Vincent Méjean, Chantal Iobbi-Nivol
To cope with environmental stresses, bacteria have evolved various strategies, including the general stress response (GSR). GSR is governed by an alternative transcriptional sigma factor named σ(S) (RpoS) that associates with RNA polymerase and controls the expression of numerous genes. Previously, we have reported that posttranslational regulation of σ(S) in the aquatic bacterium Shewanella oneidensis involves the CrsR-CrsA partner-switching regulatory system, but the exact mechanism by which CrsR and CrsA control σ(S) activity is not completely unveiled...
July 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28727759/use-of-a-microfluidic-platform-to-uncover-basic-features-of-energy-and-environmental-stress-responses-in-individual-cells-of-bacillus-subtilis
#5
Matthew T Cabeen, Jonathan R Russell, Johan Paulsson, Richard Losick
Bacteria use a variety of stress-sensing systems to sense and respond to diverse stressors and to ensure their survival under adverse conditions. The gram-positive bacterium Bacillus subtilis responds to energy stress (ATP depletion) and to environmental stressors using two distinct stress-sensing pathways that converge on the alternative sigma factor σB to provoke a general stress response. Past efforts to study the σB stress response in bulk culture and on agarose pads were unable to visualize the responses of individual cells under tightly controlled conditions for extended periods of time...
July 20, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28727722/an-attenuated-shigella-mutant-lacking-the-rna-binding-protein-hfq-provides-cross-protection-against-shigella-strains-of-broad-serotype
#6
Jiro Mitobe, Ritam Sinha, Soma Mitra, Dhrubajyoti Nag, Noriko Saito, Ken Shimuta, Nobuo Koizumi, Hemanta Koley
Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain. Here, immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection by S. dysenteriae type 1 and S. sonnei strains. This deletion mutant lacked the RNA-binding protein Hfq leading to increased expression of the type III secretion system via loss of regulation, resulting in attenuation of cell viability through repression of stress response sigma factors...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28724497/a-redesign-approach-for-improving-animal-care-services-for-researchers
#7
Orighomisan Okpe, Jamison V Kovach
Because a research institution's animal care and use program oversees the provision of services specified in approved protocols designed by researchers, the effective provision of services within these programs is paramount to ensuring the humane care and treatment of research animals in accordance with federal, state, and local regulations and institutional policies. To improve the services provided to researchers through animal care and use programs, we investigated the relationship between the researchers who conduct these types of studies and the veterinary operations that provide care and treatment for research animals...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28723845/lean-six-sigma-techniques-to-improve-ophthalmology-clinic-efficiency
#8
Thomas A Ciulla, Mohan V Tatikonda, Yehya A ElMaraghi, Rehan M Hussain, Amanda L Hill, Julie M Clary, Eyas Hattab
PURPOSE: Ophthalmologists serve an increasing volume of a growing elderly population undergoing increasingly complex outpatient medical care, including extensive diagnostic testing and treatment. The resulting prolonged patient visit times ("patient flow times") limit quality, patient and employee satisfaction, and represent waste. Lean Six Sigma process improvement was used in a vitreoretinal practice to decrease patient flow time, demonstrating that this approach can yield significant improvement in health care...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28723387/sigma-1-receptor-activation-modifies-intracellular-calcium-exchange-in-the-g93a-hsod1-als-model
#9
Vedrana Tadić, Ayse Malci, Nadine Goldhammer, Beatrice Stubendorff, Saikata Sengupta, Tino Prell, Silke Keiner, Jingyu Liu, Madlen Guenther, Christiane Frahm, Otto W Witte, Julian Grosskreutz
Aberrations in intracellular calcium (Ca(2+)) have been well established within amyotrophic lateral sclerosis (ALS), a severe motor neuron disease. Intracellular Ca(2+) concentration is controlled in part through the endoplasmic reticulum (ER) mitochondria Ca(2+) cycle (ERMCC). The ER supplies Ca(2+) to the mitochondria at close contacts between the two organelles, i.e. the mitochondria-associated ER membranes (MAMs). The Sigma 1 receptor (Sig1R) is enriched at MAMs, where it acts as an inter-organelle signalling modulator...
July 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28720220/application-of-ultrahigh-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-for-the-characterization-of-organic-aerosol-searching-for-naphthenic-acids
#10
Mahmoud M Yassine, Ewa Dabek-Zlotorzynska
Naphthenic acids (NAs) are naturally occurring constituents of hydrocarbon deposits (petroleum, oil sands bitumen, and crude oils), and present in any facilities that extract, process or use crude oil or bitumen for manufacturing. In the Athabasca oil sands region (AOSR) of Alberta, Canada, this diverse group of saturated acyclic, monocyclic, and polycyclic carboxylic acids is present in bitumen and in tailing ponds. Little is known about the occurrence of residual oil sands derived organic material, including NAs, in atmospheric particulate matter (PM)...
June 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28716934/sigma-1-receptors-control-immune-driven-peripheral-opioid-analgesia-during-inflammation-in-mice
#11
Miguel A Tejada, Angeles Montilla-García, Shane J Cronin, Domagoj Cikes, Cristina Sánchez-Fernández, Rafael González-Cano, M Carmen Ruiz-Cantero, Josef M Penninger, José M Vela, José M Baeyens, Enrique J Cobos
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether sigma-1 antagonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mice. The selective sigma-1 antagonists BD-1063 and S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute (3 h) inflammation...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28714889/staphylococcus-aureus-regulator-sigma-b-is-important-to-develop-chronic-infections-in-hematogenous-murine-osteomyelitis-model
#12
Lorena Tuchscherr, Jennifer Geraci, Bettina Löffler
Staphylococcus aureus is a major pathogen causing bone infections that can become chronic and difficult to treat. Recently, we described the mechanism employed by S. aureus to switch to small colony variants (SCVs) and trigger intracellular bacterial persistence through the global stress regulator SigB. Here, we studied the role of SigB in the formation of chronic osteomyelitis. We used a murine hematogenous osteomyelitis model, where the mice were infected via the tail vein and subsequently developed chronic osteomyelitis...
July 15, 2017: Pathogens
https://www.readbyqxmd.com/read/28711894/-markers-of-dental-children-s-health-in-the-application-of-therapeutic-orthodontic-equipment
#13
Аліса В Пачевська, Аліна В Білошицька
INTRODUCTION: Treatment of teeth anomalies using removable and non-removable orthodontic devices in children leads to complications such as caries, gingivitis, periodontitis, oral mucosa hyperplasia. Etiopathogenetical of these diseases can be associated with biochemical changes in the composition of saliva. AIM: To determine the activity of lysozyme and amylase in oral fluid in children when using a fixed and removable orthodontic devices. MATERIALS AND METHODS: Amylase and lysozyme were studied in oral fluid...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28704044/new-scandium-borylimido-chemistry-synthesis-bonding-and-reactivity
#14
Benjamin A Clough, Simona Mellino, Eric Clot, Philip Mountford
We report a combined synthetic, mechanistic and theoretical study of the first borylimido complex of a rare earth metal, (NacNacNMe2)Sc{NB(NAr'CH)2} (25, Ar' = 2,6-C6H3iPr2, NacNacNMe2 = Ar'NC(Me)CHC(Me)NCH2CH2NMe2). Thermolysis of the methyl-borylamide (NacNacNMe2)Sc(Me){NHB(NAr'CH)2} (18) generated transient imide 25 via rate-determining, 1st order methane elimination (KIE ca. 8.7). In the absence of external substrate, 25 underwent a reversible cyclometallation reaction (sp3 C-H bond addition to Sc=Nimide) with a methyl group of the NacNacNMe2 ligand forming {MeC(NC6H3iPrCH(Me)CH2)CHC(Me)NCH2CH2NMe2}-Sc{NHB(NAr'CH)2} (21)...
July 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28702490/sigma-2-receptor-ligands-qsar-model-dataset
#15
Antonio Rescifina, Giuseppe Floresta, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Giovanni Nastasi, Maria Dichiara, Emanuele Amata
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2 (σ2) receptor ligands selective over Sigma-1 (σ1) receptor. The development of the QSAR model has been undertaken with the use of CORAL software using SMILES, molecular graphs and hybrid descriptors (SMILES and graph together). Data here reported include the regression for σ2 receptor pKi QSAR models. The QSAR model was also employed to predict the σ2 receptor pKi values of the FDA approved drugs that are herewith included...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28701150/physiological-roles-of-sigma-factor-sigd-in-corynebacterium-glutamicum
#16
Hironori Taniguchi, Tobias Busche, Thomas Patschkowski, Karsten Niehaus, Miroslav Pátek, Jörn Kalinowski, Volker F Wendisch
BACKGROUND: Sigma factors are one of the components of RNA polymerase holoenzymes, and an essential factor of transcription initiation in bacteria. Corynebacterium glutamicum possesses seven genes coding for sigma factors, most of which have been studied to some detail; however, the role of SigD in transcriptional regulation in C. glutamicum has been mostly unknown. RESULTS: In this work, pleiotropic effects of sigD overexpression at the level of phenotype, transcripts, proteins and metabolites were investigated...
July 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28700608/the-ecf-sigma-factor-pspto_1043-in-pseudomonas-syringae-pv-tomato-dc3000-is-induced-by-oxidative-stress-and-regulates-genes-involved-in-oxidative-stress-response
#17
Bronwyn G Butcher, Zhongmeng Bao, Janet Wilson, Paul Stodghill, Bryan Swingle, Melanie Filiatrault, David Schneider, Samuel Cartinhour
The bacterial plant pathogen Pseudomonas syringae adapts to changes in the environment by modifying its gene expression profile. In many cases, the response is mediated by the activation of extracytoplasmic function (ECF) sigma factors that direct RNA polymerase to transcribe specific sets of genes. In this study we focus on PSPTO_1043, one of ten ECF sigma factors in P. syringae pv. tomato DC3000 (DC3000). PSPTO_1043, together with PSPTO_1042, encode an RpoERsp/ChrR-like sigma/anti-sigma factor pair. Although this gene pair is unique to the P...
2017: PloS One
https://www.readbyqxmd.com/read/28700244/targeted-yttrium-89-doxorubicin-drug-eluting-bead-a-safety-and-feasibility-pilot-study-in-a-rabbit-liver-cancer-model
#18
Johannes M Ludwig, Minzhi Xing, Yongkang Gai, Lingyi Sun, Dexing Zeng, Hyun S Kim
PURPOSE: To evaluate feasibility and safety of the cancer targeting (Radio)-Chemoembolization drug eluting bead (TRCE-DEB) concept drug SW43-DOX-L-NETA(89Y) DEB for the intra-arterial treatment of VX2 rabbit liver tumors. The treatment compound comprises of the Sigma-2 receptor ligand SW43 for cancer targeting, Doxorubicin (DOX), and 89Yttrium (89Y) as non-radioactive surrogate for therapeutic (Yttrium-90, Lutetium-177) and imaging (Yttrium-86) radioisotopes via the chelator L-NETA. MATERIAL AND METHODS: Ten New Zealand white rabbits with VX2 tumor allografts were used...
July 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28699871/two-component-system-cbra-cbrb-controls-alginate-production-in-azotobacter-vinelandii
#19
Elva Quiroz-Rocha, Fernando Bonilla-Badía, Valentina García-Aguilar, Liliana López-Pliego, Jade Serrano-Román, Miguel Cocotl-Yañez, Josefina Guzmán, Carlos L Ahumada-Manuel, Luis Felipe Muriel-Millán, Miguel Castañeda, Guadalupe Espín, Cinthia Nuñez
Azotobacter vinelandii, belonging to the Pseudomonadaceae family, is a free-living bacterium that has been considered to be a good source for the production of bacterial polymers such as alginate. In A. vinelandii the synthesis of this polymer is regulated by the Gac/Rsm post-transcriptional regulatory system, in which the RsmA protein binds to the mRNA of the biosynthetic algD gene, inhibiting translation. In several Pseudomonas spp. the two-component system CbrA/CbrB has been described to control a variety of metabolic and behavioural traits needed for adaptation to changing environmental conditions...
July 12, 2017: Microbiology
https://www.readbyqxmd.com/read/28691976/distinct-lipoprotein-curves-in-normal-weight-overweight-and-obese-children-and-adolescents
#20
Hagar Interator, Yael Lebenthal, Moshe Hoshen, Inbar Safra, Ran Balicer, Moshe Leshno, Raanan Shamir
OBJECTIVES: Pediatric lipoprotein curves are based on population-based samples. As obesity, may alter lipoprotein levels, cut-offs not adjusted for body mass index (BMI) are potentially inappropriate. We aimed to develop distinct serum lipid curves based on sex and BMI-percentiles for children and adolescents. METHODS: Cross-sectional analysis included all healthy children and adolescents (age range 2-17 years) with available serum lipid concentrations (n = 152,820 of approximately 1...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
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