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Witold H Polanski, K Daniel Martin, Swen Günther, Gabriele Schackert, Lisa Klingelhoefer, Mareike Fauser, Alexander Storch, Stephan B Sobottka
Background: For quality analysis, we applied the Six Sigma concept to define quality indicators and their boundaries as well as to compare treatment-dependent outcome data of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). Methods: The Unified Parkinson Disease Rating Scale (UPDRS) III with on medication and on stimulation, the reduction of daily levodopa equivalence doses (LED), and the stimulation amplitude 1 year after surgery were registered...
June 18, 2018: International Journal for Quality in Health Care
Anaïs Brosse, Maude Guillier
Small regulatory RNAs are now recognized as key regulators of gene expression in bacteria. They accumulate under specific conditions, most often because their synthesis is directly controlled by transcriptional regulators, including but not limited to alternative sigma factors and response regulators of two-component systems. In turn, small RNAs regulate, mostly at the posttranscriptional level, expression of multiple genes, among which are genes encoding transcriptional regulators. Small RNAs are thus embedded in mixed regulatory circuits combining transcriptional and posttranscriptional controls, and whose properties are discussed here...
May 2018: Microbiology Spectrum
Gopinadh Bhyrapuneni, Jagadeesh Babu Thentu, Abdul Rasheed Mohammed, Raghupathi Reddy Aleti, Nagasurya Prakash Padala, Devender Reddy Ajjala, Ramakrishna Nirogi
The use of liquid chromatography coupled with mass spectrometry (LC-MS/MS) is advantageous in in-vivo receptor occupancy assays at pre-clinical drug developmental stages. Relatively, its application is effective in terms of high throughput, data reproducibility, sensitivity, and sample processing. In this perspective, we have evaluated the use of FTC-146 as a non-radiolabelled tracer to determine the sigma-1 receptor occupancy of test drugs in mice brain. Further, the brain and plasma exposures of test drug were determined at their corresponding occupancies...
June 18, 2018: Journal of Receptor and Signal Transduction Research
Jie Cheng, Chun-Yan Wang, Zi-Hao Lyu, Tong Lin
To elucidate the role of glutathione S-transferases (GSTs) in Heortia vitessoides Moore (Lepidoptera: Crambidae), one of the most destructive defoliating pests in Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae) forests, 16 GST cDNAs were identified in the transcriptome of adult H. vitessoides. All cDNAs included a complete open reading frame and were designated HvGSTd1-HvGSTu2. A phylogenetic analysis showed that the 16 HvGSTs were classified into seven different cytosolic classes; three in delta, two in epsilon, three in omega, three in sigma, one in theta, two in zeta, and two in unclassified...
May 1, 2018: Journal of Insect Science
Cristiano Ialongo, Sergio Bernardini
There is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes...
June 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Rita Turnaturi, Lucia Montenegro, Agostino Marrazzo, Rosalba Parenti, Lorella Pasquinucci, Carmela Parenti
Despite the fact that the benzomorphan skeleton has mainly been employed in medicinal chemistry for the development of opioid analgesics, it is a versatile structure. Its stereochemistry, as well as opportune modifications at the phenolic hydroxyl group and at the basic nitrogen, play a pivotal role addressing the benzomorphan-based compounds to a specific target. In this review, we describe the structure activity-relationships (SARs) of benzomorphan-based compounds acting at sigma 1 receptor (σ1R), sigma 2 receptor (σ2R), voltage-dependent sodium channel, N-Methyl-d-Aspartate (NMDA) receptor-channel complex and other targets...
June 7, 2018: European Journal of Medicinal Chemistry
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Kenichi Ogawa, Katsunori Yoshikawa, Fumio Matsuda, Yoshihiro Toya, Hiroshi Shimizu
Photoinhibition, or cell damage caused by excessively intense light is a major issue for the industrial use of cyanobacteria. To investigate the mechanism of responses to extreme high light intensity, gene expression analysis was performed using the model cyanobacterium Synechocystis sp. PCC 6803 (PCC 6803) cultured under various light intensities. The culture profile data demonstrated that, in contrast to the slow cell growth observed under low light intensities (30 and 50 μmol m-2  s-1 ), maximal cell growth was observed under mid light conditions (300 and 1000 μmol m-2  s-1 )...
June 12, 2018: Journal of Bioscience and Bioengineering
Z Nakudashvili, I Mgebrishvili, I Barbakadze, T Sanikidze
The purpose of our study was a comparative analysis of the effect of dentures from various materials on the immunological and redox-dependent homeostasis of the oral cavity. We studied 60 patients with removable dentures made based on plastics Prothyl Hot, Vertex BasiQ 20 (differing by polymerization regime) and elastic thermoplastic polymer Perflex Flexi Nylon. The control group consisted of 15 volunteers with a practically healthy oral cavity, who did not use dentures. Saliva collected on an empty stomach in a glass tube without the use of a stimulator before the establishment of a denture and 3 days and 1 month after...
May 2018: Georgian Medical News
Edward W Randell, Garry Short, Natasha Lee, Allison Beresford, Margaret Spencer, Marina Kennell, Zoë Moores, David Parry
Six Sigma involves a structured process improvement strategy that places processes on a pathway to continued improvement. The data presented here summarizes a project that took three clinical laboratories from autoverification processes that allowed between about 40% to 60% of tests being auto-verified to more than 90% of tests and samples auto-verified. The project schedule, metrics and targets, a description of the previous system and detailed information on the changes made to achieve greater than 90% auto-verification is presented for this Six Sigma DMAIC (Design, Measure, Analyze, Improve, Control) process improvement project...
June 2018: Data in Brief
Rafael Vieira Coelho, Scheila de Avila E Silva, Sergio Echeverrigaray, Ana Paula Longaray Delamare
This paper presents a prediction of Bacillus subtilis promoters using a Support Vector Machine system. In the literature, there is a lack of information on Gram-positive bacterial promoter sequences compared to Gram-negative bacteria. Promoter sequence identification is essential for studying gene expression. Initially, we collected the B. subtilis genome sequence from the NCBI database, and promoters were identified by their sigma factors in the DBTBS database. We then grouped the promoters according to 15 factors in 2 domains, corresponding to sigma 54 and sigma 70 of Gram-negative bacteria...
August 2018: Data in Brief
Kamran Saeidi, Farid Akhtar
Stainless steel 316 L prepared by laser melting consisted of a hierarchical austenitic microstructure with micrometre-sized (10-25 µm) grains containing fine 1 µm subgrains with a cellular structure. At high-temperature thermal treatments (greater than or equal to 1100°C), merging and growth of the 1 µm subgrains into bigger subgrains restricted the rapid grain growth and microstructure coarsening. Partial phase transformation of austenite to ferrite at temperatures greater than or equal to 1100°C, in combination with gradual and steady growth of subgrains inside the micrometre-sized grains and nucleation of the sigma phase, has promoted the tensile strength of stainless steel 316 L to 300 MPa at 1100°C compared with that of conventionally made 316 L counterparts (approx...
May 2018: Royal Society Open Science
Sergey V Guselnikov, Konstantin O Baranov, Alexander M Najakshin, Ludmila V Mechetina, Nikolai A Chikaev, Alexey I Makunin, Sergey V Kulemzin, Daria A Andreyushkova, Matthias Stöck, Sven Wuertz, Jörn Gessner, Wesley C Warren, Manfred Schartl, Vladimir A Trifonov, Alexander V Taranin
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish. First, based on the bioinformatic analysis of recent transcriptomic and genomic resources, we experimentally characterized the IgL genes in the chondrostean fish, Acipenser ruthenus (sterlet). We show that this species has three loci encoding IgL kappa-like chains with a translocon-type gene organization and a single VJC cluster, encoding homogeneous lambda-like light chain...
2018: Frontiers in Immunology
Wiktor Zierkiewicz, Mariusz Michalczyk, Steve Scheiner
The σ-hole tetrel bonds formed by a tetravalent molecule are compared with those involving a π-hole above the tetrel atom in a trivalent bonding situation. The former are modeled by TH₄, TH₃F, and TH₂F₂ (T = Si, Ge, Sn) and the latter by TH₂=CH₂, THF=CH₂, and TF₂=CH₂, all paired with NH₃ as Lewis base. The latter π-bonded complexes are considerably more strongly bound, despite the near equivalence of the σ and π-hole intensities. The larger binding energies of the π-dimers are attributed to greater electrostatic attraction and orbital interaction...
June 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mary Godley, Jeanne B Jenkins
BACKGROUND: Patient satisfaction scores in the vascular interventional radiology department were low, especially related to wait times in registration and for tests/treatments, with low scores for intentions to recommend. PURPOSE: The purpose of our quality improvement project was to decrease wait times and improve patient satisfaction using Lean Six Sigma's define, measure, analyze, improve, and control (DMAIC) framework with a pre-/postintervention design. RESULTS: There was a statistically significant decrease in wait times (P < ...
June 8, 2018: Journal of Nursing Care Quality
Tamara Tse, Thomas Linden, Leonid Churilov, Stephen Davis, Geoffrey Donnan, Leeanne M Carey
RESEARCH QUESTION: 1. Does activity participation improve over time in the first year after stroke? 2. What is the association of depressive symptoms on retained activity participation 12-months post-stroke adjusting for neurological stroke severity and age? 3. Is an improvement in activity participation associated with a decrease in depressive symptoms between 3- and 12-months post-stroke? DESIGN: Longitudinal observational study of activity participation and depressive symptoms in ischemic stroke survivors...
June 11, 2018: Disability and Rehabilitation
Aimi Nadia Binti Razlan, Muzammil Ullah, Marina Yurievna Kapitonova, Norhayati Binti Liaqat Ali Khan, Syed Baharom Syed Ahmad Fuad
The aim of the study was to investigate the location of motor neuron somata of geniohyoid muscle in rat. Nine Sprague-Dawley rats were used in this study. Operations were performed under general anaesthesia. Nembutal sodium, 40 mg per kg intraperitoneally was used for anaesthesia. 0.02 to 0.05 ml of 30% horseradish peroxidase (Sigma Type VI) solution in normal saline was injected into the exposed right geniohyoid muscle. After 48 hr, the animals were fixed by perfusion through left ventricle of heart, first by 100 ml normal saline and then with 500 ml of 1...
June 11, 2018: Anatomia, Histologia, Embryologia
Simen Akkermans, Philippe Nimmegeers, Jan F Van Impe
Building mathematical models in predictive microbiology is a data driven science. As such, the experimental data (and its uncertainty) has an influence on the final predictions and even on the calculation of the model prediction uncertainty. Therefore, the current research studies the influence of both the parameter estimation and uncertainty propagation method on the calculation of the model prediction uncertainty. The study is intended as well as a tutorial to uncertainty propagation techniques for researchers in (predictive) microbiology...
May 29, 2018: International Journal of Food Microbiology
Yukihide Minoda, Ryo Sugama, Yoichi Ohta, Mitsuhiko Ikebuchi, Hiroaki Nakamura
BACKGROUND: Patella-post impingement (PPI), contact of the patellar component with the tibial post, occurs during deep knee flexion after posterior stabilized total knee arthroplasty (TKA). In a previous pilot study, only two product lines were investigated. The aim of this study was to compare PPI between 12 contemporary posterior stabilized knee prostheses. METHODS: Twelve posterior stabilized knee prostheses were implanted in full-length sawbone models of the femur and tibia using a navigation system...
June 5, 2018: Knee
Alex S Arvanitakis, Chris D A Blair
We construct the exceptional sigma model: a two-dimensional sigma model coupled to a supergravity background in a manifestly (formally) E_{D(D)}-covariant manner. This formulation of the background is provided by exceptional field theory (EFT), which unites the metric and form fields of supergravity in E_{D(D)} multiplets before compactification. The realization of the symmetries of EFT on the world sheet uniquely fixes the Weyl-invariant Lagrangian and allows us to relate our action to the usual type-IIA fundamental string action and a form of the type-IIB (m, n) action...
May 25, 2018: Physical Review Letters
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