keyword
https://read.qxmd.com/read/38058097/parp-inhibitors-in-colorectal-malignancies-a-2023-update
#21
JOURNAL ARTICLE
Nikolaos Skouteris, Georgios Papageorgiou
BACKGROUND: Colorectal carcinoma (CRC) is one of the most common malignancies in the Western world, and metastatic disease is associated with a dismal prognosis. Poly-ADpribose polymerase (PARP) inhibitors gain increasing attention in the field of medical oncology, as they lead to synthetic lethality in malignancies with preexisting alterations in the DNA damage repair (DDR) pathway. As those alterations are frequently seen in CRC, a targeted approach through PARP inhibitors is expected to benefit these patients, both alone and in combination with other agents like chemotherapy, immunotherapy, antiangiogenics, and radiation...
December 6, 2023: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38054850/mhy446-induces-apoptosis-via-reactive-oxygen-species-mediated-endoplasmic-reticulum-stress-in-hct116-human-colorectal-cancer-cells
#22
JOURNAL ARTICLE
Yu Ra Ahn, Jung Yoon Jang, Yong Jung Kang, Hye Jin Oh, Min Kyung Kang, Dahye Yoon, Hyung Sik Kim, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Kim
This study investigated the potential of a newly synthesized histone deacetylase (HDAC) inhibitor, MHY446, in inducing cell death in HCT116 colorectal cancer cells and compared its activity with that of suberoylanilide hydroxamic acid (SAHA), a well-known HDAC inhibitor. The results showed that MHY446 increased the acetylation of histones H3 and H4 and decreased the expression and activity of HDAC proteins in HCT116 cells. Additionally, MHY446 was confirmed to bind more strongly to HDAC1 than HDAC2 and inhibit its activity...
December 6, 2023: Journal of Chemotherapy
https://read.qxmd.com/read/38024994/curcumin-loaded-porous-particles-functionalized-with-ph-responsive-cell-penetrating-peptide-for-colorectal-cancer-targeted-drug-delivery
#23
JOURNAL ARTICLE
Zhila Izadi, Maryam Rashidi, Hossein Derakhshankhah, Mozhdeh Dolati, Mohammad Ghanbari Kermanshahi, Hadi Adibi, Hadi Samadian
The anticancer properties of curcumin have been broadly examined in several shapes, such as nanoparticles and nanocomposite structures. Despite its benefits, curcumin also has some disadvantages, including rapid metabolism, poor absorption, and rapid systemic excretion. Therefore, numerous strategies have been used to increase curcumin's bioavailability. One of these approaches is the use of porous particles like aerogels as drug carriers. Aerogels are special due to their peculiar physical structure. They have a high specific surface area, a significant amount of porosity, and a solid composition, which make them a good choice for drug delivery systems...
November 22, 2023: RSC Advances
https://read.qxmd.com/read/38023716/tissue-adhesive-indocyanine-green-locking-granular-gel-mediated-photothermal-therapy-combined-with-checkpoint-inhibitor-for-preventing-postsurgical-recurrence-and-metastasis-of-colorectal-cancer
#24
JOURNAL ARTICLE
Yuan Zeting, Ma Shuli, Li Yue, Fang Haowei, Shang Jing, Zhan Yueping, Wang Jie, Chen Teng, Deng Wanli, Kunxi Zhang, Yin Peihao
Developing effective therapy to inhibit postoperative recurrence and metastasis of colorectal cancer (CRC) is challenging and significant to reduce mortality and morbidity. Here, a granular hydrogel, assembled from gelatin microgels by dialdehyde starch and interpenetrated with in situ polymerized poly(sulfobetaine methacrylate- co -N-isopropylacrylamide) (P(SBMA- co -NIPAM)), is prepared to load and lock Food and Drug Administration (FDA)-approved indocyanine green (ICG) with definite photothermal function and biosafety for photothermal therapy (PTT) combining with checkpoint inhibitor...
November 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38006397/manganese-dioxide-entrapping-dendrimers-co-deliver-protein-and-nucleotide-for-magnetic-resonance-imaging-guided-chemodynamic-starvation-immune-therapy-of-tumors
#25
JOURNAL ARTICLE
Yue Gao, Zhijun Ouyang, Siyan Shen, Hongwei Yu, Bingyang Jia, Han Wang, Mingwu Shen, Xiangyang Shi
Development of a nanoscale drug delivery system that can simultaneously exert efficient tumor therapeutic efficacy while creating the desired antitumor immune responses is still challenging. Herein, we report the use of a manganese dioxide (MnO2 )-entrapping dendrimer nanocarrier to codeliver glucose oxidase (GOx) and cyclic GMP-AMP (cGAMP), an agonist of the stimulator of interferon genes (STING) for improved tumor chemodynamic/starvation/immune therapy. Methoxy poly(ethylene glycol) ( m PEG)- and phenylboronic acid (PBA)-modified generation 5 (G5) poly(amidoamine) dendrimers were first synthesized and then entrapped with MnO2 nanoparticles (NPs) to generate the hybrid MnO2 @G5- m PEG-PBA (MGPP) NPs...
December 12, 2023: ACS Nano
https://read.qxmd.com/read/37972906/improved-antitumor-activity-through-a-tyramidyl-maslinic-acid-derivative-design-and-validation-as-drug-loaded-electrospun-polymeric-nanofibers
#26
JOURNAL ARTICLE
Cristina Luque, María de la Cabeza Fernández, David Fuentes-Rios, Ana Cepero, Rafael Contreras-Cáceres, Manuel Doña, Gloria Perazzoli, Laura Lozano-Chamizo, Marco Filice, Marzia Marciello, Victor Gonzalez-Rumayor, Juan Manuel López-Romero, Laura Cabeza, Consolación Melguizo, José Prados
Among the most harmful tumors detected in the human body, such as breast, colon, brain or pancreas, breast (BC) and colorectal cancer (CRC) are the first and third most frequent cancer worldwide, respectively. The current existing chemotherapeutic treatments present serious side effects due to their intravenous administration can induce cytotoxicity in healthy cells. Thus, new treatment methods based on drug-loaded polymeric nanofibers (NFs) have gained significant potential for their use in localized cancer chemotherapy...
November 14, 2023: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/37968472/apc-pik3ca-mutations-and-%C3%AE-catenin-status-predict-tankyrase-inhibitor-sensitivity-of-patient-derived-colorectal-cancer-cells
#27
JOURNAL ARTICLE
Mingjue Chen, Tetsuo Mashima, Taichi Oishi, Yukiko Muramatsu, Yosuke Seto, Manabu Takamatsu, Naomi Kawata, Shun Morino, Ayane Nakamura, Saori Inaba, Xunmei Yuan, Kohei Maruyama, Mai Suzuki, Ayana Sato, Haruka Yoshida, Myung-Kyu Jang, Anna Mizutani, Kengo Takeuchi, Kensei Yamaguchi, Fumiyuki Shirai, Satoshi Nagayama, Ryohei Katayama, Hiroyuki Seimiya
BACKGROUND: Aberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize AXINs, β-catenin repressors. Tankyrase inhibitors block WNT/β-catenin signaling and colorectal cancer (CRC) growth. We previously reported that 'short' APC mutations, lacking all seven β-catenin-binding 20-amino acid repeats (20-AARs), are potential predictive biomarkers for CRC cell sensitivity to tankyrase inhibitors. Meanwhile, 'Long' APC mutations, which possess more than one 20-AAR, do not predict inhibitor-resistant cells...
November 15, 2023: British Journal of Cancer
https://read.qxmd.com/read/37956925/size-tunable-nanogels-for-cascaded-release-of-metronidazole-and-chemotherapeutic-agents-to-combat-fusobacterium-nucleatum-infected-colorectal-cancer
#28
JOURNAL ARTICLE
Shuang Xie, Li Wei, Yuan Liu, Jie Meng, Wenxiong Cao, Bo Qiu, Xiaohong Li
Bacteria play important roles in tumor formation, growth and metastasis through downregulating immune response and initiating drug resistance. Herein, size-tunable nanogels (NGs) have been developed to address the existing size paradox in tumor accumulation, intratumoral penetration and intracellular release of therapeutics for the treatment of Fusobacterium nucleatum (F. nucleatum)-infected colorectal cancer. Zinc-imidazolate frameworks with doxorubicin (DOX) loading and folate grafting (f-ZIFD ) were mixed with metronidazole (MET) and encapsulated in NGs through thiol-ene click crosslinking of sulfhydryl hyaluronan, sulfhydryl alginate and 4-arm poly(ethylene glycol) acrylate...
November 11, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37940081/co-delivering-irinotecan-and-imiquimod-by-ph-responsive-micelle-amplifies-anti-tumor-immunity-against-colorectal-cancer
#29
JOURNAL ARTICLE
Wenlu Yan, Yu Li, Yiting Zou, Runqi Zhu, Ting Wu, Wenhui Yuan, Tianqun Lang, Yaping Li, Qi Yin
Irinotecan (IRT), a classic clinical chemotherapeutic agent for treating colorectal cancer, has been found to induce immunogenic cell death (ICD) while exerting cytotoxicity in tumor cells. This effect is likely to be amplified in combination with immune modulators. Unfortunately, free drugs without targeting capacity would receive poor outcomes and strong side effects. To address these issues, in this work, an acid-sensitive micelle based on an amphiphilic poly(β-amino ester) derivative was constructed to co-deliver IRT and the immune adjuvant imiquimod (IMQ), termed PII...
November 6, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/37902628/4-3-phenyl-4-3-4-5-trimethoxybenzoyl-1-h-pyrrol-1-yl-benzenesulfonamide-a-novel-carbonic-anhydrase-and-wnt-%C3%AE-catenin-signaling-pathway-dual-targeting-inhibitor-with-potent-activity-against-multidrug-resistant-cancer-cells
#30
JOURNAL ARTICLE
Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D'Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Sciò, Viviana Orlando, Sara D'Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Cinzia Fionda, Rosa Bordone, Giorgia Della Rocca, Gianluca Canettieri, Claudiu T Supuran, Romano Silvestri, Giuseppe La Regina
We synthesized new pyrrole and indole derivatives as human carbonic anhydrase (hCA) inhibitors with the potential to inhibit the Wnt/β-catenin signaling pathway. The presence of both N 1-(4-sulfonamidophenyl) and 3-(3,4,5-trimethoxyphenyl) substituents was essential for strong hCA inhibitors. The most potent hCA XII inhibitor 15 ( K i = 6.8 nM) suppressed the Wnt/β-catenin signaling pathway and its target genes MYC, Fgf20, and Sall4 and exhibited the typical markers of apoptosis, cleaved poly(ADP-ribose)polymerase, and cleaved caspase-3...
October 30, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/37898773/a-carrier-free-supramolecular-nano-twin-drug-for-overcoming-irinotecan-resistance-and-enhancing-efficacy-against-colorectal-cancer
#31
JOURNAL ARTICLE
Miaomiao Yuan, Tong Chen, Lu Jin, Peng Zhang, Luoyijun Xie, Shuyi Zhou, Lianfeng Fan, Li Wang, Cai Zhang, Ning Tang, LiHao Guo, Chengmei Xie, Yanhong Duo, Ling Li, Leilei Shi
Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate adverse events. Poly-ADP-Ribose Polymerase (PARP) participates in the maintenance of genome stability and the repair of DNA damage, thus playing a critical role in chemotherapy resistance. In this work, we introduce a novel curative strategy that utilizes nanoparticles (NPs) prepared by dynamic supramolecular co-assembly of Ir and a PARP inhibitor (PARPi) niraparib (Nir) through π-π stacking and hydrogen bond interactions...
October 28, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/37863059/an-activity-based-functional-test-for-identifying-homologous-recombination-deficiencies-across-cancer-types-in-real-time
#32
JOURNAL ARTICLE
Chih-Ying Lee, Wen-Fang Cheng, Po-Han Lin, Yu-Li Chen, Shih-Han Huang, Kai-Hang Lei, Ko-Yu Chang, Min-Yu Ko, Peter Chi
Homologous recombination (HR)-mediated DNA repair is a prerequisite for maintaining genome stability. Cancer cells displaying HR deficiency (HRD) are selectively eliminated by poly(ADP-ribose) polymerase inhibitors (PARPis). To date, sequencing of HR-associated genes and analyzing genome instability have been used as clinical predictions for PARPi therapy. However, these genetic tests cannot reflect dynamic changes in the HR status. Here, we have developed a virus- and activity-based functional assay to quantify real-time HR activity directly...
October 12, 2023: Cell reports medicine
https://read.qxmd.com/read/37841928/long-non-coding-rna-h19-enhances-the-pro-apoptotic-activity-of-itf2357-a-histone-deacetylase-inhibitor-in-colorectal-cancer-cells
#33
JOURNAL ARTICLE
Chiara Zichittella, Marco Loria, Adriana Celesia, Diana Di Liberto, Chiara Corrado, Riccardo Alessandro, Sonia Emanuele, Alice Conigliaro
Introduction: Long non-coding RNA H19 (lncH19) is highly expressed in colorectal cancer (CRC) and plays critical roles in tumor development, proliferation, metastasis, and drug resistance. Indeed, the expression of lncH19 usually affects the outcomes of chemo-, endocrine, and targeted therapies. ITF2357 (givinostat) is a histone deacetylase inhibitor (HDACi) that revealed a significant anti-tumor action by inducing apoptosis in different tumor models, including leukemia, melanoma, and glioblastoma. However, no data are present in the literature regarding the use of this compound for CRC treatment...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37830460/cd44-targeted-delivery-of-hyaluronic-acid-coated-polymeric-nanoparticles-against-colorectal-cancer
#34
JOURNAL ARTICLE
Niraj Phatak, Sankha Bhattacharya, Disha Shah, Laxmi Manthalkar, Putrevu Sreelaya, Arinjay Jain
Aim: To develop hyaluronic acid (HA)-coated poly-lactic-co-glycolic acid (PLGA)-polysarcosine (PSAR) coupled sorafenib tosylate (SF) polymeric nanoparticles for targeted colon cancer therapy. Materials & methods: PLGA-PSAR shells were encapsulated with SF via nanoprecipitation. Interactions were examined with transmission electron microscopy, revealing formulation component interactions. Results: The optimized HA-coated polymeric nanoparticles (238.8 nm, -6.1 mV, 68.361% entrapment) displayed enhanced controlled release of SF...
October 13, 2023: Nanomedicine
https://read.qxmd.com/read/37730576/chemopreventive-effect-of-a-milk-whey-by-product-derived-from-buffalo-bubalus-bubalis-in-protecting-from-colorectal-carcinogenesis
#35
JOURNAL ARTICLE
Nunzio Antonio Cacciola, Tommaso Venneri, Angela Salzano, Nunzia D'Onofrio, Manuela Martano, Anella Saggese, Francesco Vinale, Gianluca Neglia, Ciro Campanile, Loredana Baccigalupi, Paola Maiolino, Mariarosaria Cuozzo, Roberto Russo, Maria Luisa Balestrieri, Michael John D'Occhio, Ezio Ricca, Francesca Borrelli, Giuseppe Campanile
BACKGROUND: Several studies show that natural foods are a source of compounds with anticancer properties that affect the gut microbiota and its metabolites. In the present study, we investigate the effect of a delactosed buffalo milk whey by-product (DMW) on colorectal carcinogenesis. METHODS: The effect of DMW on colorectal carcinoma (CRC) was investigated in the established mouse model of azoxymethane (AOM)-induced colon carcinoma, which closely resembles the human clinical condition of CRC...
September 20, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37686423/targeted-therapy-for-cancers-from-ongoing-clinical-trials-to-fda-approved-drugs
#36
REVIEW
Ha Yeong Choi, Ji-Eun Chang
The development of targeted therapies has revolutionized cancer treatment, offering improved efficacy with reduced side effects compared with traditional chemotherapy. This review highlights the current landscape of targeted therapy in lung cancer, colorectal cancer, and prostate cancer, focusing on key molecular targets. Moreover, it aligns with US Food and Drug Administration (FDA)-approved drugs and drug candidates. In lung cancer, mutations in the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements have emerged as significant targets...
September 3, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37669142/genetic-variants-that-impact-alternative-polyadenylation-in-cancer-represent-candidate-causal-risk-loci
#37
JOURNAL ARTICLE
Bin Li, Yimin Cai, Can Chen, Gaoyuan Li, Ming Zhang, Zequn Lu, Fuwei Zhang, Jinyu Huang, Linyun Fan, Caibo Ning, Yanmin Li, Wenzhuo Wang, Hui Geng, Yizhuo Liu, Shuoni Chen, Hanting Li, Shuhui Yang, Heng Zhang, Wen Tian, Zhongchao Zhu, Bin Xu, Heng Li, Haijie Li, Meng Jin, Xiaoyang Wang, Shaokai Zhang, Jiuyang Liu, Chaoqun Huang, Xiaojun Yang, Yongchang Wei, Ying Zhu, Jianbo Tian, Xiaoping Miao
UNLABELLED: Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression of cancer, suggesting that the genetic determinants of APA might play an important role in regulating cancer risk. Here, we depicted a pan-cancer atlas of human APA quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 cancer types. Systematic multiomics analyses indicated that cancer apaQTLs could contribute to APA regulation by altering poly(A) motifs, RNA-binding proteins (RBP), and chromatin regulatory elements and were preferentially enriched in genome-wide association studies (GWAS)-identified cancer susceptibility loci...
November 1, 2023: Cancer Research
https://read.qxmd.com/read/37642651/association-of-nonalcoholic-fatty-liver-disease-with-colorectal-adenomatous-polyps-and-non-adenomatous-polyps-a-cross-sectional-study
#38
JOURNAL ARTICLE
Yingxue Yang, Yajie Teng, Jiayi Shi, Jianhao Xu, Jie Bao, Xia Zhang, Qinghua Wang
AIM: This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD. METHODS: A retrospective, cross-sectional study was conducted at the First People's Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who underwent abdominal ultrasonography and colonoscopy over a 5 year period...
August 23, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37634281/braf-p-v600e-mutation-as-a-molecular-boundary-between-genuine-oligo-repeated-and-poly-metastatic-disease-in-colorectal-cancer
#39
JOURNAL ARTICLE
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Monica Ianniello, Marika Casillo, Nadia Petrillo, Francesco Sabbatino, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Vittorio Albino, Vincenza Granata, Francesco Izzo, Annabella Di Mauro, Massimiliano Berretta, Raffaella Ruggiero, Oreste Gualillo, Roberto Sirica, Guglielmo Nasti, Giovanni Savarese
No abstract text is available yet for this article.
August 25, 2023: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/37611648/promotion-of-colorectal-cancer-progression-by-immune-related-lnc-sox9-4-via-suppression-of-ybx1-poly-ubiquitination-and-degradation
#40
JOURNAL ARTICLE
Yan Zhao, Sheng Yang, Hongxu Nie, Dongsheng Zhang, Tuo Wang, Qingyang Sun, Xiaowei Wang, Yueming Sun
BACKGROUND: Recent research has highlighted the versatile functions of long non-coding RNAs (lncRNAs) in the onset and progression of various malignancies. Still, insufficient knowledge is available on how lnc-SOX9-4 functions in colorectal cancer (CRC) progression. METHODS: Bioinformatics analysis was used to identify a novel lncRNA (lnc-SOX9-4), and the expression pattern of the RNA in CRC was verified using qRT-PCR. Gene ontology (GO) term analysis and Gene set enrichment analysis (GSEA) were implemented for the identification of the related mechanisms and roles of lnc-SOX9-4...
August 21, 2023: Cellular Signalling
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