keyword
MENU ▼
Read by QxMD icon Read
search

Colorectal polys

keyword
https://www.readbyqxmd.com/read/29755670/systemic-inflammatory-status-predict-the-outcome-of-k-ras-wt-metastatic-colorectal-cancer-patients-receiving-the-thymidylate-synthase-poly-epitope-peptide-anticancer-vaccine
#1
Pierpaolo Correale, Cirino Botta, Nicoletta Staropoli, Valerio Nardone, Pierpaolo Pastina, Cristina Ulivieri, Claudia Gandolfo, Tatiana Cosima Baldari, Stefano Lazzi, Domenico Ciliberto, Rocco Giannicola, Antonella Fioravanti, Antonio Giordano, Silvia Zappavigna, Michele Caraglia, Pierfrancesco Tassone, Luigi Pirtoli, Maria Grazia Cusi, Pierosandro Tagliaferri
TSPP is an anticancer poly-epitope peptide vaccine to thymidylate synthase, recently investigated in the multi-arm phase Ib TSPP/VAC1 trial. TSPP vaccination induced immune-biological effects and showed antitumor activity in metastatic colorectal cancer (mCRC) patients and other malignancies. Progression-free and overall survival of 41 mCRC patients enrolled in the study correlated with baseline levels of CEA, immune-inflammatory markers (neutrophil/lymphocyte ratio, CRP, ESR, LDH, ENA), IL-4 and with post-treatment change in p-ANCA and CD56dim CD16bright NKs ( p < 0...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29749542/the-hdac6-inhibitor-acy%C3%A2-1215-enhances-the-anticancer-activity-of-oxaliplatin-in-colorectal-cancer-cells
#2
Dong Hoon Lee, Hye-Rim Won, Hyun-Wook Ryu, Jung Min Han, So Hee Kwon
ACY‑1215, also known as ricolinostat, is a leading histone deacetylase 6 inhibitor, which is currently being tested in clinical trials for hematological malignancies. Previous studies have reported that ACY‑1215 is not potent enough as a monotherapy for the treatment of colorectal cancer (CRC), which generally requires combination therapy for successful treatment. Therefore, the present study aimed to determine whether the synergistic interaction detected between ACY‑1215 and anticancer agents in hematological cancers could occur in solid tumors...
May 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29716915/psmd5-inactivation-promotes-26s-proteasome-assembly-during-colorectal-tumor-progression
#3
Avi Levin, Adi Minis, Gadi Lalazar, Jose Rodriguez, Hermann Steller
Protein degradation by the ubiquitin-proteasome system (UPS) is central to protein homeostasis and cell survival. The active 26S proteasome is a large protease complex consisting of a catalytic 20S subunit and 19S regulatory particles. Cancer cells are exposed to considerable protein overload due to high metabolic rates, reprogrammed energy metabolism and aneuploidy. Here we report a mechanism that facilitates the assembly of active 26S proteasomes in malignant cells. Upon tumorigenic transformation of the gut epithelium, 26S proteasome assembly was significantly enhanced, but levels of individual subunits were not changed...
May 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29695684/effects-of-recombinant-circularly-permuted-tumor-necrosis-factor-tnf-related-apoptosis-inducing-ligand-trail-recombinant-mutant-human-trail-in-combination-with-5-fluorouracil-in-human-colorectal-cancer-cell-lines-hct116-and-sw480
#4
Tongyou Sun, Tienian Zhu, Xiujun Liang, Shifang Yang, Ruijing Zhao
BACKGROUND Circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, a mutant form of tumor necrosis factor-related apoptosis-inducing ligand, is an effective antitumor cytokine. However, its antitumor effect in colorectal cancer is unclear. This study assessed the antitumor effect of circularly permuted tumor necrosis factor-related apoptosis-inducing ligand alone or with 5-fluorouracil in colorectal cancer cells in vitro and explored the underlying mechanisms. MATERIAL AND METHODS We used the (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) assay to analyze cell proliferation inhibition...
April 26, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29688721/nano-encapsulation-of-novel-inhibitors-of-pnkp-for-selective-sensitization-to-ionizing-radiation-and-irinotecan-and-induction-of-synthetic-lethality
#5
Zahra Shire, Mohammad Reza Vakili, Timothy D R Morgan, Dennis G Hall, Afsaneh Lavasanifar, Michael Weinfeld
There is increasing interest in developing and applying DNA repair inhibitors in cancer treatment to augment the efficacy of radiation and conventional genotoxic chemotherapy. However, targeting the inhibitor is required to avoid reducing the repair capacity of normal tissue. The aim of this study was to develop nano-delivery systems for the encapsulation of novel imidopiperidine-based inhibitors of the DNA 3'-phosphatase activity of polynucleotide kinase/phosphatase (PNKP), a DNA repair enzyme that plays a critical role in rejoining DNA single- and double-strand breaks...
April 24, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29666858/polytyrosine-nanoparticles-enable-ultra-high-loading-of-doxorubicin-and-rapid-enzyme-responsive-drug-release
#6
Xiaolei Gu, Min Qiu, Huanli Sun, Jian Zhang, Liang Cheng, Chao Deng, Zhiyuan Zhong
Despite the great significance of clinically viable nanovehicles, very few of them exhibit stability and high anticancer drug loading with fast intracellular drug release. Herein, we report that polytyrosine nanoparticles (PTNs) self-assembled from poly(ethylene glycol)-b-poly(l-tyrosine) block copolymer enable the ultra-high loading and rapid enzyme-responsive release of doxorubicin (DOX). Notably, PTNs achieve a remarkably high DOX loading of 63.1 wt% likely due to the existence of strong π-π stacking between polytyrosine and DOX, as shown by UV-vis analysis...
April 18, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29662619/uev1a-ubc13-promotes-colorectal-cancer-metastasis-through-regulating-cxcl1-expression-via-nf-%C3%B0%C2%BAb-activation
#7
Zhaojia Wu, Heather Neufeld, Eminao Torlakovic, Wei Xiao
Colorectal cancer is the second most common cause of cancer-related death worldwide. Uncontrolled growth and distant metastasis are hallmarks of colorectal cancer. However, the precise etiological factors and the mechanisms are diverse and still largely unclear. The potential proto-oncogene UEV1A encodes a ubiquitin conjugating enzyme variant, which is required for Ubc13-catalyzed K63-linked poly-ubiquitination of target proteins and the activation of NF-кB, a transcription factor known to be involved in innate immunity, anti-apoptosis, inflammation and cancer...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29620285/effect-of-hoxa6-on-the-proliferation-apoptosis-migration-and-invasion-of-colorectal-cancer-cells
#8
Shasha Wu, Feixiang Wu, Zheng Jiang
Colorectal cancer (CRC) is one of the most common types of tumor worldwide. The morbidity and mortality rates of CRC have increased significantly in adults <50 years of age. In the present study, the effects of homeobox A6 (HOXA6) on the proliferation, apoptosis, migration and invasion of CRC cells were investigated. The results of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis demonstrated that the expression of HOXA6 in CRC tumor tissue was higher than that in adjacent normal tissue...
April 2, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29620273/p38-inhibitor-inhibits-the-apoptosis-of-cowanin-treated-human-colorectal-adenocarcinoma-cells
#9
Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasin
Colorectal cancer, which is the third most common type of cancer diagnosed in both men and women, is the leading cause of cancer-related deaths worldwide. Cowanin is a pure compound extracted from Garcinia cowa Roxb., a tree species present in Thailand, Malaysia and Myanmar. The crude extract has been demonstrated to have antitumor activity, inflammation induction, antibacterial activity, anti-inflammatory activity and antimalarial activity. In the present study, the effects of cowanin on apoptosis induction and on the apoptosis-related and mitogen-activated protein kinase (MAPK) pathways were investigated in the LoVo human colorectal cancer cell line...
April 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29590112/active-braf-v600e-is-the-key-player-in-generation-of-a-sessile-serrated-polyp-specific-dna-methylation-profile
#10
Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones
BACKGROUND: Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of SSPs is largely unknown with existing genetic studies confined to a limited number of oncogenes and tumor suppressors. A full characterization of the genetic and epigenetic landscape of SSPs would provide insight into their origin and potentially offer new biomarkers useful for detection of SSPs in stool samples...
2018: PloS One
https://www.readbyqxmd.com/read/29579325/a-phase-2-study-of-the-parp-inhibitor-veliparib-plus-temozolomide-in-patients-with-heavily-pretreated-metastatic-colorectal-cancer
#11
Michael J Pishvaian, Rebecca S Slack, Wei Jiang, A Ruth He, Jimmy J Hwang, Amy Hankin, Karen Dorsch-Vogel, Divyesh Kukadiya, Louis M Weiner, John L Marshall, Jonathan R Brody
BACKGROUND: Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors such as veliparib are potent sensitizing agents and have been safely combined with DNA-damaging agents such as temozolomide. The sensitizing effects of PARP inhibitors are magnified when cells harbor DNA repair defects. METHODS: A single-arm, open-label, phase 2 study was performed to investigate the disease control rate (DCR) after 2 cycles of veliparib plus temozolomide in patients with metastatic colorectal cancer (mCRC) refractory to all standard therapies...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29545011/supramolecular-polymeric-chemotherapy-based-on-cucurbit-7-uril-peg-copolymer
#12
Hao Chen, Yueyue Chen, Han Wu, Jiang-Fei Xu, Zhiwei Sun, Xi Zhang
We develop a strategy of supramolecular polymeric chemotherapy based on a new kind of water-soluble polymer that bears cucurbit[7]uril (CB[7]) in the main-chain. To this end, we synthesized a bis-alkynyl functionalized CB[7] and polymerized it with α,ω-diazide-PEG through click reaction to form the desired CB[7] based main-chain polymer (poly-CB[7]). Anticancer drug, oxaliplatin, could be encapsulated into the cavity of poly-CB[7] to form a supramolecular polymeric complex, which displayed low cytotoxicity to normal cells...
February 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29519158/cd133-targeted-delivery-of-self-assembled-pegylated-carboxymethylcellulose-sn38-nanoparticles-to-colorectal-cancer
#13
Mona Alibolandi, Khalil Abnous, Sajjad Anvari, Marzieh Mohammadi, Mohammad Ramezani, Seyed Mohammad Taghdisi
Poor aqueous solubility of chemotherapeutics such as SN38 (7-ethyl-10-hydroxycamptothecin) and the associated systemic adverse effects are serious limitations of their clinical use. To improve the drug delivery efficiency of such compounds, they were covalently conjugated to hydrophilic macromolecular carriers that specifically deliver the drug moiety to the tumour cells. In the current study, we developed a PEGylated acetylated carboxymethylcellulose conjugate of SN38 which was covalently attached to an aptamer against a cancer stem cell marker, CD133...
March 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29484409/suppression-of-the-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-colon-cancer-cells-by-the-natural-compound-riccardin-d-from-dumortierahirsute
#14
Huiping Liu, Guoning Li, Bin Zhang, Deqing Sun, Jing Wu, Fang Chen, Feng Kong, Yun Luan, Wen Jiang, Rongmei Wang, Xia Xue
Colorectal cancer (CRC) is a major cause of mortality and morbidity. Chronic inflammation is closely associated with the development, progression and prognosis of the majority of intestinal malignancies. In recent years, targeting the nuclear factor (NF)‑κB signaling pathway for CRC therapy has become an attractive strategy. Riccardin D, a novel macrocyclicbis (bibenzyl) compound, was isolated from the Chinese liverwort plant. Previous studies have suggested that Riccardin D exerted chemo‑preventative effects against the intestinal malignancy formation...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29478780/inherited-dna-repair-defects-in-colorectal-cancer
#15
Saud H AlDubayan, Marios Giannakis, Nathanael D Moore, G Celine Han, Brendan Reardon, Tsuyoshi Hamada, Xinmeng Jasmine Mu, Reiko Nishihara, Zhirong Qian, Li Liu, Matthew B Yurgelun, Sapna Syngal, Levi A Garraway, Shuji Ogino, Charles S Fuchs, Eliezer M Van Allen
Colorectal cancer (CRC) heritability has been estimated to be around 30%. However, mutations in the known CRC-susceptibility genes explain CRC risk in fewer than 10% of affected individuals. Germline mutations in DNA-repair genes (DRGs) have recently been reported in CRC, but their contribution to CRC risk is largely unknown. We evaluated the gene-level germline mutation enrichment of 40 DRGs in 680 unselected CRC individuals and 27,728 ancestry-matched cancer-free adults. Significant findings were then examined in independent cohorts of 1,661 unselected CRC individuals and 1,456 individuals with early-onset CRC...
March 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29451980/nanocarrier-composed-of-magnetite-core-coated-with-three-polymeric-shells-mediates-lcs-1-delivery-for-synthetic-lethal-therapy-of-blm-defective-colorectal-cancer-cells
#16
Anuradha Gupta, Anas Ahmad, Hardeep Singh, Sharanjeet Kaur, Neethu K M, Md Meraj Ansari, Govindasamy Jayamurugan, Rehan Khan
Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded nanocarrier (LCS-1-NC). The drug LCS-1 has poor aqueous solubility. To overcome its limitations, a customized NC, composed of a magnetite core coated with three polymeric shells, namely, aminocellulose (AC), branched poly(amidoamine), and paraben-PEG, was developed for encapsulating LCS-1...
March 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29441979/using-pva-and-tpgs-as-combined-emulsifier-in-nanoprecipitation-method-improves-characteristics-and-anticancer-activity-of-ibuprofen-loaded-plga-nanoparticles
#17
A Sahin, F Spiroux, I Guedon, F B Arslan, E T Sarcan, T Ozkan, N Colak, S Yuksel, S Ozdemir, B Ozdemir, S Akbas, G Ultav, Y Aktas, Y Capan
In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly(lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA-TPGS (d-α-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29425857/a-disposable-immunosensor-using-ito-based-electrode-modified-by-a-star-shaped-polymer-for-analysis-of-tumor-suppressor-protein-p53-in-human-serum
#18
Muhammet Aydın, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
Label-free immunosensor based on tetra armed star-shaped poly(glycidylmethacrylate) (StarPGMA ) modified disposable ITO electrode was developed for detection of p53 protein, an important colorectal cancer biomarker. This disposable biosensor was fabricated by spin-coating technique using star-shaped StarPGMA with epoxy side groups. After formation of a stable film with epoxy ends, anti-p53 antibodies were bound to these groups covalently. Stepwise modification of the electrode was followed by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) studies...
June 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29399200/synergistic-inhibition-of-colon-cancer-cell-growth-by-a-combination-of-atorvastatin-and-phloretin
#19
Mo Zhou, Jinkai Zheng, Jinfeng Bi, Xinye Wu, Jian Lyu, Kun Gao
Atorvastatin (ATST), a drug commonly used to reduce the levels of cholesterol and low-density lipoproteins, is a prospective agent for the prevention of colorectal cancer in patients with hyperlipidemia. ATST in combination with functional components is a promising strategy for cancer chemoprevention. In the present study, the growth inhibitory effect of ATST combined with phloretin (PT) on SW620 and HCT116 colon cancer cells was investigated. The results of MTT assays indicated that the combination of PT and ATST markedly reduced cell survival in both cell lines compared with PT or ATST treatment administered individually...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29383150/molecular-crosstalk-between-ferroptosis-and-apoptosis-emerging-role-of-er-stress-induced-p53-independent-puma-expression
#20
Se Hoon Hong, Dae-Hee Lee, Young-Sun Lee, Min Jee Jo, Yoon A Jeong, William T Kwon, Haroon A Choudry, David L Bartlett, Yong J Lee
Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and other forms of cell death such as apoptosis. Human pancreatic cancer PANC-1 and BxPC-3 and human colorectal cancer HCT116 cells were treated with ferroptotic agents such as erastin and artesunate (ART) in combination with the apoptotic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
December 29, 2017: Oncotarget
keyword
keyword
37691
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"