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iwatani ryuji

Yosuke Nakayama, Seiji Ueda, Sho-ichi Yamagishi, Nana Obara, Kensei Taguchi, Ryotaro Ando, Yusuke Kaida, Ryuji Iwatani, Kumiko Kaifu, Miyuki Yokoro, Maki Toyonaga, Takuo Kusumoto, Kei Fukami, Seiya Okuda
Ischemia/reperfusion injury is the leading cause of acute tubular necrosis. Nitric oxide has a protective role against ischemia/reperfusion injury; however, the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, in ischemia/reperfusion injury remains unclear. ADMA is produced by protein arginine methyltransferase (PRMT) and is mainly degraded by dimethylarginine dimethylaminohydrolase (DDAH). Here we examined the kinetics of ADMA and PRMT and DDAH expression in the kidneys of ischemia/reperfusion-injured mice...
March 2014: Kidney International
Yoshimi Takamiya, Kei Fukami, Sho-ichi Yamagishi, Yusuke Kaida, Yosuke Nakayama, Nana Obara, Ryuji Iwatani, Ryotaro Ando, Kiyomi Koike, Takanori Matsui, Yuri Nishino, Seiji Ueda, Mark E Cooper, Seiya Okuda
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is responsible for the degradation of various types of extracellular matrix (ECM) proteins such as type IV collagen. Decreased MMP-2 expression and activity has been generally thought to contribute to increased accumulation of ECM at the advanced stage of diabetic nephropathy. However, the kinetics and role of MMP-2 in the early phase of diabetic nephropathy remain unclear. To address this issue, we examined whether streptozotocin (STZ)-induced early diabetic nephropathy was accelerated in MMP-2 knockout (KO) mice...
January 2013: Nephrology, Dialysis, Transplantation
Yusuke Kaida, Seiji Ueda, Sho-ichi Yamagishi, Yosuke Nakayama, Ryotaro Ando, Ryuji Iwatani, Kei Fukami, Seiya Okuda
AIMS: Proteinuria is an independent risk factor for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Asymmetric dimethylarginine (ADMA) is a mediator of endothelial dysfunction and is associated with proteinuria in CKD patients. Thus, ADMA can partially account for the increased risk of CVD in CKD patients presenting proteinuria. However, a causal relationship between proteinuria and ADMA remains to be demonstrated. MAIN METHODS: We first investigated whether and how proteinuria might increase ADMA levels in adriamycin (ADR)-treated rats...
September 24, 2012: Life Sciences
Kiyomi Koike, Kei Fukami, Koji Yonemoto, Ryuji Iwatani, Rimi Obata, Kaoru Ueda, Maki Toyonaga, Seiji Ueda, Atsuko Ohara, Kazuhito Takeda, Sho-Ichi Yamagishi, Seiya Okuda
BACKGROUND/AIMS: Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-positive microscopic polyangiitis patients with renal involvement have been shown to have a progressive clinical course. In this study, we compared the clinical utility of the Japanese Vasculitis Activity Score (JVAS) with the Birmingham Vasculitis Activity Score (BVAS) for predicting death in patients with MPO-ANCA-associated renal involvement. METHODS: Sixty-nine patients with MPO-ANCA-associated vasculitis with renal involvement (22 males and 47 females, age 69...
2012: American Journal of Nephrology
Junko Yoshimura, Kei Fukami, Kiyomi Koike, Makio Nagano, Takafumi Matsumoto, Ryuji Iwatani, Takuo Kusumoto, Takuma Hazama, Seiji Ueda, Hisashi Adachi, Yuji Hirai, Konomi Takasu, Koichi Ohshima, Sho-ichi Yamagishi, Seiya Okuda
1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we examined the relationship between expression of forkhead box P3 (Foxp3) and T cell intracytoplasmic antigen (TIA)-1, T(reg) and CTL markers and renal survival in patients with MPO-ANCA-GN. 2. Forty patients with MPO-ANCA-GN and 10 patients with minimal change nephrotic syndrome (MCNS) underwent physical examination, determination of blood chemistry and renal biopsy...
September 2010: Clinical and Experimental Pharmacology & Physiology
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