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https://www.readbyqxmd.com/read/29229473/cystic-fibrosis-research-topics-featured-at-the-14th-ecfs-basic-science-conference-chairman-s-summary
#1
Marcus A Mall, Tzyh-Chang Hwang, Ineke Brakman
In recent years, tremendous progress has been made in the development of novel drugs targeting the basic defect in patients with cystic fibrosis (CF). This breakthrough is based on a solid foundation of knowledge on CFTR's function in health and how mutations in CFTR cause CF multi-organ disease. This knowledge has been collected and continuously expanded by an active and persistent CF research community and has paved the way for precision medicine for CF. Since 2004, the European Cystic Fibrosis Society (ECFS) has held an annual Basic Science Conference that has evolved as an international forum for interdisciplinary discussion of hot topics and unsolved questions related to CF research...
December 8, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29199662/efficacy-and-safety-of-first-line-systemic-chemotherapy-with-epirubicin-cisplatin-plus-5-fluorouracil-and-docetaxel-cisplatin-plus-5-fluorouracil-regimens-in-locally-advanced-inoperable-or-metastatic-gastric-or-gastroesophageal-junction-adenocarcinoma-a-prospective
#2
K G Babu, T Chaudhuri, K C Lakshmaiah, L Dasappa, L A Jacob, McS Babu, A H Rudresha, K N Lokesh, L K Rajeev
BACKGROUND: Patients with locally advanced inoperable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma have a poor prognosis. The maximum benefit of systemic chemotherapy is usually achieved in the first-line setting. Even though systemic chemotherapy has been used for long time, in view of unsatisfactory results, no standard regimen has been emerged. Unfortunately, till date, there is no published prospective data from India, comparing the two most commonly used triplet regimens, epirubicin, cisplatin plus 5-fluorouracil (ECF) and docetaxel, cisplatin plus 5-fluorouracil (DCF), in this patient population...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29196045/cystic-fibrosis-a-call-for-papers-for-ecfs-2018
#3
Emma Grainger
No abstract text is available yet for this article.
November 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29187086/nutrition-management-of-home-parenteral-nutrition-among-patients-with-enterocutaneous-fistula-in-the-sustain-registry
#4
Charlene Compher, Marion F Winkler, Peggi Guenter, Ezra Steiger
BACKGROUND: Home parenteral nutrition (HPN) is a vital therapy for patients who have the diagnosis of enterocutaneous fistula (ECF), yet little is known about how these patients are managed. This research compares nutrition management of adults with ECF as the indication for HPN therapy to those with other indications. METHODS: This is an analysis of data from adult HPN patients in the Sustain registry enrolled between August 2011 and February 2014 who have the diagnosis of ECF or other indication for HPN who served as the control group...
February 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29184768/identifying-osteoporotic-vertebral-endplate-and-cortex-fractures
#5
REVIEW
Yì Xiáng J Wáng, Fernando Ruiz Santiago, Min Deng, Marcello H Nogueira-Barbosa
Osteoporosis is the most common metabolic bone disease, and vertebral fractures (VFs) are the most common osteoporotic fracture. A single atraumatic VF may lead to the diagnosis of osteoporosis. Prevalent VFs increase the risk of future vertebral and non-vertebral osteoporotic fracture independent of bone mineral density (BMD). The accurate and clear reporting of VF is essential to ensure patients with osteoporosis receive appropriate treatment. Radiologist has a vital role in the diagnosis of this disease...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29182901/surgery-for-post-operative-entero-cutaneous-fistulas-is-bowel-resection-plus-primary-anastomosis-without-stoma-a-safe-option-to-avoid-early-recurrence-report-on-20-cases-by-a-single-center-and-systematic-review-of-the-literature
#6
A Lauro, R Cirocchi, N Cautero, A Dazzi, D Pironi, F M Di Matteo, A Santoro, S Faenza, L Pironi, A D Pinna
BACKGROUND: A review was performed on entero-cutaneous fistula (ECF) repair and early recurrence, adding our twenty adult patients (65% had multiple fistulas). METHODS: The search yielded 4.098 articles but only 15 were relevant: 1.217 patients underwent surgery. The interval time between fistula's diagnosis and operative repair was between 3 months and 1 year. A bowel resection with primary anastomosis was performed in 1.048 patients, 192 (18.3%) underwent a covering stoma: 856 patients (81...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29151703/3d-printed-fistula-stent-designed-for-management-of-enterocutaneous-fistula-an-advanced-strategy
#7
Jin-Jian Huang, Jian-An Ren, Ge-Fei Wang, Zong-An Li, Xiu-Wen Wu, Hua-Jian Ren, Song Liu
Enterocutaneous fistulas (ECFs) are great challenges during the open abdomen. The loss of digestive juice, water-electrolyte imbalance and malnutrition are intractable issues during management of ECF. Techniques such as "fistula patch" and vacuum-assisted closure therapy have been applied to prevent contamination of open abdominal wounds by intestinal fistula drainage. However, failures are encountered due to high-output fistula and anatomical complexity. Here, we report 3D-printed patient-personalized fistula stent for ECF treatment based on 3D reconstruction of the fistula image...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29112621/the-role-of-extracellular-fluid-in-biokinetic-modeling
#8
Guthrie Miller, John A Klumpp, Dunstana Melo, Deepesh Poudel
The pharmacokinetic equations of Pierson et al. describing the behavior of bromide in rat provide a general approach to the modeling of extracellular fluid (ECF). The movement of material into ECF spaces is rapid and is completely characterized by tissue volumes and vascular flow rates to and from a tissue, the volumes of the tissue, and the ECF associated with the tissue. Early-time measurements are needed to characterize ECF. Measurements of DTPA disappearance from plasma by Wedeking et al. are discussed as an example of such measurements...
December 2017: Health Physics
https://www.readbyqxmd.com/read/29100759/-one-pot-ethyl-chloroformate-derivatization-and-liquid-liquid-extraction-of-reduced-glutathione-in-erythrocyte-and-its-quantitative-gc-ms-analysis
#9
Alessandra Manca, Eugenio Alladio, Paola Massarenti, M Paola Puccinelli, Antonella De Francesco, Erika Del Grosso, Giulio Mengozzi, Marco Pazzi, Marco Vincenti
A simple "one-pot" derivatization and liquid-liquid extraction (LLE) procedure was developed for GC-MS analysis of reduced glutathione (GSH) analysis in erythrocytes. The metabolite was extracted by 5% (w/v) TCA, the supernatant treated with ECF and ethanol-pyridine media, the derivative separated and detected by gas chromatography-mass spectrometry using a short non-polar capillary GC column at a high column-head pressure. Total analysis time was 11min. The process was optimized by a Design of Experiment. The method was validated showing a good linearity over the 25...
October 20, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29093476/in-vivo-neurochemical-measurements-in-cerebral-tissues-using-a-droplet-based-monitoring-system
#10
Guillaume Petit-Pierre, Philippe Colin, Estelle Laurer, Julien Déglon, Arnaud Bertsch, Aurélien Thomas, Bernard L Schneider, Philippe Renaud
Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temporal resolution. Here we show a functional in vivo validation of a droplet collection system included at the tip of a neural probe. The system comprises an advanced droplet formation mechanism which enables the collection of neurochemicals present in the brain ECF at high-temporal resolution. The probe was implanted in a rat brain and could successfully collect fluid samples organized in a train of droplets...
November 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29089037/revisiting-atenolol-as-a-low-passive-permeability-marker
#11
Xiaomei Chen, Tim Slättengren, Elizabeth C M de Lange, David E Smith, Margareta Hammarlund-Udenaes
BACKGROUND: Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood-brain barrier (BBB) and the intestinal epithelium. However, the extent of S-atenolol (the active enantiomer) distribution in brain has never been evaluated, at equilibrium, to confirm that no transporters are involved in its transport at the BBB. METHODS: To assess whether S-atenolol, in fact, depicts the characteristics of a low passive permeable drug at the BBB, a microdialysis study was performed in rats to monitor the unbound concentrations of S-atenolol in brain extracellular fluid (ECF) and plasma during and after intravenous infusion...
October 31, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29079615/%C3%AE-glucanase-activity-of-the-oral-bacterium-tannerella-forsythia-contributes-to-the-growth-of-a-partner-species-fusobacterium-nucleatum-in-co-biofilms
#12
Kiyonobu Honma, Angela Ruscitto, Ashu Sharma
Tannerella forsythia and Fusobacterium nucleatum are dental plaque bacteria implicated in the development of periodontitis. These two species have been shown to form synergistic biofilms and found to be closely associated in dental plaque biofilms. A number of genetic loci for TonB-dependent membrane receptors (TDR) for glycan acquisition, with many existing in association with genes coding for enzymes involved in the breakdown of complex glycans, have been identified in T. forsythia In this study, we focused on a locus, BFO_0186 -- BFO_0188, that codes for a predicted TDR-SusD transporter along with a putative β-glucan hydrolyzing enzyme (BFO_0186)...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29069433/modulation-of-extracytoplasmic-function-ecf-sigma-factor-promoter-selectivity-by-spacer-region-sequence
#13
Ahmed Gaballa, Veronica Guariglia-Oropeza, Franziska Dürr, Bronwyn G Butcher, Albert Y Chen, Pete Chandrangsu, John D Helmann
The ability of bacteria to adapt to stress depends on the conditional expression of specific sets of genes. Bacillus subtilis encodes seven extracytoplasmic function (ECF) sigma (σ) factors that regulate functions important for survival under conditions eliciting cell envelope stress. Of these, four have been studied in detail: σ M , σ W , σ X and σ V . These four σ factors recognize overlapping sets of promoters, although the sequences that determine this overlapping recognition are incompletely understood...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29064568/utility-of-preoperative-holter-monitoring-in-children-undergoing-extracardiac-conduit-fontan-operation
#14
Jun Sasaki, Michael M Lopez, Sherrie J Baysa, Ronald J Kanter, Anthony F Rossi
BACKGROUND: In patients undergoing extracardiac conduit Fontan (ECF) who require postoperative pacing, epicardial leads are usually required because of anatomical constraints. If indicated, these could be conveniently placed at the time of ECF. We have routinely performed ambulatory 24-hour Holter monitoring before ECF to determine the presence or absence of preoperative sinus node dysfunction, in attempt to avoid repeat sternotomy at a later time. METHODS: We performed a retrospective study of all patients undergoing ECF from January 2000 to December 2015...
October 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29059500/role-of-extracytoplasmic-function-sigma-factor-pg1660-rpoe-in-the-oxidative-stress-resistance-regulatory-network-of-porphyromonas-gingivalis
#15
Yuetan Dou, Hiel Rutanhira, Xin Chen, Arunima Mishra, Charles Wang, Hansel M Fletcher
In Porphyromonas gingivalis, PG1660 composed of 174 amino acids, is annotated as an extracytoplasmic function (ECF) sigma factor (RpoE homologue-σ24). Because PG1660 can modulate several virulence factors and responds to environmental signals in P. gingivalis, its genetic properties were further evaluated. PG1660 is co-transcribed with its downstream gene PG1659, and the transcription start site was identified as an adenine residue 54-nt upstream of the ATG translation start codon. In addition to binding its own promoter, using the purified rPG1660 and RNAP core enzyme from E...
October 23, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29035211/error-correcting-factorization
#16
Miguel Angel Bautista, Oriol Pujol, Fernando de la Torre, Sergio Escalera
Error Correcting Output Codes (ECOC) is a successful technique in multi-class classification, which is a core problem in Pattern Recognition and Machine Learning. A major advantage of ECOC over other methods is that the multi-class problem is decoupled into a set of binary problems that are solved independently. However, literature defines a general error-correcting capability for ECOCs without analyzing how it distributes among classes, hindering a deeper analysis of pairwise error-correction. To address these limitations this paper proposes an Error-Correcting Factorization (ECF) method...
October 16, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/29024715/proposal-of-a-flow-scheme-for-the-chemical-form-based-quantitative-analysis-of-chlorine-compounds-in-pulp-for-sanitary-products-and-verification-of-safety
#17
Takeharu Wada, Kei Iwasaki, Yasushi Minobe, Mitsuhiro Wada, Shigeo Imai, Satoko Ishii
To determine the amounts and chemical forms of chlorine compounds in elemental chlorine-free (ECF) bleached pulp for sanitary products, a chemical-form-based quantitative analysis flow scheme was created. The scheme involves quantitative determination of compounds eluted in elution tests assuming dermal exposure. The results indicated that most of the chlorine compounds in pulp used for sanitary products were insoluble organically bound chlorine and water-soluble chlorides consisting of chloride ions. The total amount of chlorine obtained by analysis of the total chlorine in the pulp products was close to the sum of the amounts of water-soluble chlorides, residual chlorine, chloroacetic acids, and insoluble organically bound chlorine...
October 9, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29018122/the-bvgas-regulon-of-bordetella-pertussis
#18
Kyung Moon, Richard P Bonocora, David D Kim, Qing Chen, Joseph T Wade, Scott Stibitz, Deborah M Hinton
Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgA~P), and virulence-activated genes (vags) are expressed [Bvg(+) mode]. When BvgS is inactive and BvgA is not phosphorylated, virulence-repressed genes (vrgs) are induced [Bvg(-) mode]. Here, we have used transcriptome sequencing (RNA-seq) and reverse transcription-quantitative PCR (RT-qPCR) to define the BvgAS-dependent regulon of B...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28993557/biological-functions-of-glucolipids-in-bacillus-subtilis
#19
Satoshi Matsuoka
Glyceroglycolipids are very important in Gram-positive bacteria and cyanobacteria. In Bacillus subtilis, a model organism for the Gram-positive bacteria, the ugtP mutant, which lacks glyceroglucolipids, shows abnormal morphology. Lack of glucolipids has many consequences: abnormal localization of the cytoskeletal protein MreB and activation of some extracytoplasmic function (ECF) sigma factors (σ(M), σ(V) and σ(X)) in the log phase are two examples. Conversely, the expression of monoglucosyldiacylglycerol (MGlcDG) by 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii (alMGS) almost completely suppresses the ugtP disruptant phenotype...
October 6, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28976791/adjuvant-chemoradiotherapy-with-epirubicin-cisplatin-and-fluorouracil-compared-with-adjuvant-chemoradiotherapy-with-fluorouracil-and-leucovorin-after-curative-resection-of-gastric-cancer-results-from-calgb-80101-alliance
#20
RANDOMIZED CONTROLLED TRIAL
Charles S Fuchs, Donna Niedzwiecki, Harvey J Mamon, Joel E Tepper, Xing Ye, Richard S Swanson, Peter C Enzinger, Daniel G Haller, Tomislav Dragovich, Steven R Alberts, Georg A Bjarnason, Christopher G Willett, Leonard L Gunderson, Richard M Goldberg, Alan P Venook, David Ilson, Eileen O'Reilly, Kristen Ciombor, David J Berg, Jeffrey Meyerhardt, Robert J Mayer
Purpose After curative resection of gastric or gastroesophageal junction adenocarcinoma, Intergroup Trial 0116 (Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocarcinoma: Demonstrated superior survival for patients who received postoperative chemoradiotherapy with bolus fluorouracil (FU) and leucovorin (LV) compared with surgery alone. CALGB 80101 (Alliance; Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma) assessed whether a postoperative chemoradiotherapy regimen that replaced FU plus LV with a potentially more active systemic therapy could further improve overall survival...
November 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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