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https://www.readbyqxmd.com/read/28043799/the-expansion-and-performance-of-national-newborn-screening-programmes-for-cystic-fibrosis-in-europe
#1
Jürg Barben, Carlo Castellani, Jeannette Dankert-Roelse, Silvia Gartner, Nataliya Kashirskaya, Barry Linnane, Sarah Mayell, Anne Munck, Dorota Sands, Olaf Sommerburg, Simon Pybus, Victoria Winters, Kevin W Southern
BACKGROUND: Newborn screening (NBS) for cystic fibrosis (CF) is a well-established public health strategy with international standards. The aim of this study was to provide an update on NBS for CF in Europe and assess performance against the standards. METHODS: Questionnaires were sent to key workers in each European country. RESULTS: In 2016, there were 17 national programmes, 4 countries with regional programmes and 25 countries not screening in Europe...
December 30, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28041771/the-effect-of-comorbidities-on-discharge-disposition-and-readmission-for-total-joint-arthroplasty-patients
#2
Jakub Sikora-Klak, Bradley Zarling, Christopher Bergum, Jeffrey C Flynn, David C Markel
BACKGROUND: As the annual demand and number of total joint arthroplasty cases increase, so do concerns of outcomes of patient with specific comorbidities relative to outcomes and costs of care. METHODS: The study cohort included 2009 primary total knee arthroplasty (TKA) patients and 905 total hip arthroplasty patients. Discharge disposition was classified as discharge to any facility or home. The comorbidities of the patients who were readmitted and those without a 90-day event were also evaluated...
November 29, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28039627/enhancement-of-chlorella-vulgaris-harvesting-via-the-electro-coagulation-flotation-ecf-method
#3
Y K Wong, Y H Ho, H M Leung, K C Ho, Y H Yau, K K L Yung
This article explores the potential of using an electro-coagulation-flotation (ECF) harvester to allow flotation of microalgae cells for surface harvesting. A response surface methodology (RSM) model was used to optimize ECF harvesting by adjusting electrode plate material, electrode plate number, charge of the electrodes, electrolyte concentration, and pH value of the culture solution. The result revealed that three aluminum electrode plates (one anode and two cathodes), brine solution (8 g/L), and acidity (pH = 4) of culture solution (optimized ECF harvester) The highest flocculant concentration was measured at 2966 mg/L after 60 min and showed a 79...
December 30, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28035250/from-traditional-serrated-adenoma-to-tubulovillous-adenoma-and-beyond
#4
REVIEW
Sangeetha N Kalimuthu, Adeline Chelliah, Runjan Chetty
It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated polyps. TSAs are characterised by the presence of a "pinecone-like" architecture, granular eosinophilic cytoplasm, luminal serrations, ectopic crypt foci (ECF) and elongated, pencillate nuclei. However, the distinct slit-like luminal serrations, reminiscent of small bowel mucosa, appear to be the most unique and reproducible feature to distinguish TSAs from other polyps...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28033076/a-simplified-technique-for-interventional-extracardiac-fontan
#5
Sudesh Prabhu, Ben Anderson, Cameron Ward, Tom Karl, Nelson Alphonso
PURPOSE: We report a simple technique for an interventional extracardiac Fontan (ECF) procedure. DESCRIPTION: At the preparatory stage along with a bidirectional cavopulmonary connection (BCPC; cardiopulmonary bypass), a short piece of polytetrafluoroethylene (PTFE) tube graft is anastomosed to the inferior surface of the right pulmonary artery. Another longer PTFE graft is anastomosed to the transected inferior vena cava (IVC). A large medial opening in the lower PTFE graft is anastomosed to an atriotomy...
January 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28030494/traumatic-colon-injury-in-damage-control-laparotomy-a-multicenter-trial-is-it-safe-to-do-a-delayed-anastomosis
#6
Leah Tatebe, Andrew Jennings, Ken Tatebe, Alexandra Handy, Purvi Prajapati, Michael Smith, Tai Do, Gerald O Ogola, Rajesh R Gandhi, Therese M Duane, Stephen Luk, Laura B Petrey
BACKGROUND: Delayed colonic anastomosis after damage control laparotomy (DCL) is an alternative to colostomies during a single laparotomy (SL) in high-risk patients. However, literature suggests increased colonic leak rates up to 27% with DCL, and various reported risk factors. We evaluated our regional experience to determine if delayed colonic anastomosis was associated with worse outcomes. METHODS: A multi-center retrospective cohort study was performed across three Level I Trauma Centers encompassing traumatic colon injuries from January 2006 through June 2014...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28017640/cystic-fibrosis-a-call-for-papers-for-the-ecfs-meeting
#7
Emma Grainger
No abstract text is available yet for this article.
December 22, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28017572/data-sharing-between-providers-and-quality-initiatives-eliminate-unnecessary-nursing-home-admissions
#8
Ryan J Charles, Bonita M Singal, Andrew G Urquhart, Michael A Masini, Brian R Hallstrom
BACKGROUND: The Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) has monitored discharge disposition, after total hip and knee arthroplasties, since inception in 2012 and found the standardized risk of extended care facility (ECF) placement to be highly variable between hospitals. METHODS: The variation in standardized risks of ECF placement among MARCQI member sites was reported to the collaborative. At the May 2, 2014 quarterly meeting, a quality initiative was started, emphasizing the wide variability between hospitals, the contribution of hospital and surgeon to that variability using median odds ratios, and the need for outlier hospitals to initiate quality improvement (QI) processes...
November 28, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27979485/discharge-destination-and-readmission-rates-in-older-trauma-patients
#9
David S Strosberg, Blain Chaise Housley, Daniel Vazquez, Amy Rushing, Steven Steinberg, Christian Jones
BACKGROUND: In older trauma patients, the impact of discharge destination on readmission rates is not known. The objective of this study was to evaluate the association between the discharge destination and the 30-day readmission rate in older trauma patients. MATERIALS AND METHODS: A previously validated database of all patients aged 45 years or older undergoing trauma evaluation at our level 1 trauma center between January 1, 2008 and December 31, 2008 was analyzed to retrospectively compare the incidences of 30-day readmission between patients discharged to home, to inpatient rehabilitation facilities, and to other extended care facilities (ECFs)...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27965645/glucose-induces-ecf-sigma-factor-genes-sigx-and-sigm-independent-of-cognate-anti-sigma-factors-through-acetylation-of-csha-in-bacillus-subtilis
#10
Mitsuo Ogura, Kei Asai
Extracytoplasmic function (ECF) σ factors have roles related to cell envelope and/or cell membrane functions, in addition to other cellular functions. Without cell-surface stresses, ECF σ factors are sequestered by the cognate anti-σ factor, leading to inactivation and the resultant repression of regulons due to the inhibition of transcription of their own genes. Bacillus subtilis has seven ECF σ factors including σ(X) and σ(M) that transcribe their own structural genes. Here, we report that glucose addition to the medium induced sigX and sigM transcription independent of their anti-σ factors...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27940243/sigch-an-extracytoplasmic-function-sigma-factor-of-porphyromonas-gingivalis-regulates-the-expression-of-cdhr-and-hmuyr
#11
Koki Ota, Yuichiro Kikuchi, Kentaro Imamura, Daichi Kita, Kouki Yoshikawa, Atsushi Saito, Kazuyuki Ishihara
Extracytoplasmic function (ECF) sigma factors play an important role in the bacterial response to various environmental stresses. Porphyromonas gingivalis, a prominent etiological agent in human periodontitis, possesses six putative ECF sigma factors. So far, information is limited on the ECF sigma factor, PGN_0319. The aim of this study was to investigate the role of PGN_0319 (SigCH) of P. gingivalis, focusing on the regulation of hmuY and hmuR, which encode outer-membrane proteins involved in hemin utilization, and cdhR, a transcriptional regulator of hmuYR...
December 8, 2016: Anaerobe
https://www.readbyqxmd.com/read/27913762/aspen-felanpe-clinical-guidelines
#12
Vanessa J Kumpf, Jose Eduardo de Aguilar-Nascimento, Jose Ignacio Diaz-Pizarro Graf, Amber M Hall, Liam McKeever, Ezra Steiger, Marion F Winkler, Charlene W Compher
BACKGROUND: The management of patients with enterocutaneous fistula (ECF) requires an interdisciplinary approach and poses a significant challenge to physicians, wound/stoma care specialists, dietitians, pharmacists, and other nutrition clinicians. Guidelines for optimizing nutrition status in these patients are often vague, based on limited and dated clinical studies, and typically rely on individual institutional or clinician experience. Specific nutrient requirements, appropriate route of feeding, role of immune-enhancing formulas, and use of somatostatin analogues in the management of patients with ECF are not well defined...
January 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27893673/risk-factor-and-outcome-for-intra-abdominal-bleeding-in-patients-with-enterocutaneous-fistula
#13
Lei Wu, Jianan Ren, Qinjie Liu, Gefei Wang, Xiuwen Wu, Guosheng Gu, Guanwei Li, Kun Guo, Zhiwu Hong, Qiongyuan Hu, Huajian Ren, Jieshou Li
Intra-abdominal bleeding is a major and lethal complication in patients with enterocutaneous fistula (ECF) while few studies are involved in this aspect. In the present study, we aimed to investigate the risk factors and assessed the outcome for intra-abdominal bleeding in patients with ECF.A retrospective study was performed from October 2013 to October 2015. Medical records of 67 ECF patients with intra-abdominal bleeding and 134 ECF patients without intra-abdominal bleeding matched as controls were reviewed and analyzed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27873747/atypical-presentation-of-appendicitis
#14
Oliver Beaumont, Robert Miller, Richard Guy
A woman aged 64 years presented as an emergency with a mass in the right iliac fossa, clinically within the abdominal wall, but an otherwise soft abdomen. Systemically, she was quite well with normal vital signs. Blood tests revealed raised inflammatory markers, and an abdominal CT scan demonstrated a perforated appendix with associated large subcutaneous abscess. This represents a rare presentation of a common condition, demonstrating how appendicitis can still be a challenging problem for the clinician...
November 10, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27866464/endometriotic-cyst-fluid-induces-reactive-oxygen-species-ros-in-human-immortalized-epithelial-cells-derived-from-ovarian-endometrioma
#15
Yoichi Kobayashi, Kiyono Osanai, Kei Tanaka, Yoshiko Nishigaya, Hironori Matsumoto, Mai Momomura, Masamichi Hashiba, Shizuka Mita, Satoru Kyo, Mitsutoshi Iwashita
OBJECTIVES: Endometriotic cyst fluid (ECF) contains a large amount of reactive oxygen species (ROS), and endometriotic cysts are exposed to strong oxidative stress, which may cause malignant transformation. In this study, ROS production by ECF was clinically analysed. METHODS: Human immortalized epithelial cells derived from ovarian endometrioma (EMosis-CC/TERT 1) were treated with ECF. In addition, ROS production in EMosis-CC/TERT 1 was measured, and its clinical significance was analysed...
November 20, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27847669/novel-approach-for-enterocutaneous-fistula-treatment-with-the-use-of-viable-cryopreserved-placental-membrane
#16
Frederick Nichols, Aaron Overly
Enterocutaneous fistulas (ECF) are a difficult and costly surgical complication to manage. The standard treatment of nil per os (NPO) and total paraenteral nutrition (TPN) is not well tolerated by patients. TPN is also known for complications associated with long term central venous catheterization and for high cost of prolonged hospital stay. We present two low output ECF cases successfully treated with viable cryopreserved placental membrane (vCPM) placed into the fistula tracts. One patient is a 59-year-old male with a low output ECF from a jejunostomy tube site four weeks after the surgery...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27808443/evaluating-the-potential-of-effluent-extracts-from-pulp-and-paper-mills-in-canada-brazil-and-new-zealand-to-affect-fish-reproduction-estrogenic-effects-in-fish
#17
Rodrigo Orrego, Craig B Milestone, L Mark Hewitt, John Guchardi, Tatiana Heid-Furley, Alison Slade, Deborah L MacLatchy, Douglas Holdway
The authors examined the potential of pulp mill effluent from pulp-producing countries (Canada, Brazil, New Zealand) to affect fish reproduction. Specifically, the estrogenic effects in juvenile rainbow trout (Oncorhynchus mykiss) pulse-exposed to 11 different mill effluent extracts (intraperitoneal injections of solid-phase extraction-dichloromethane nonpolar fraction). The results indicated that effluent extracts were estrogenic in juvenile trout irrespective of the gender, as reflected by increasing level of plasma vitellogenin (VTG; Brazil > New Zealand > Canada)...
November 3, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27796702/equilibrium-and-non-equilibrium-concentration-fluctuations-in-a-critical-binary-mixture
#18
Fabio Giavazzi, Alessandro Fornasieri, Alberto Vailati, Roberto Cerbino
When a macroscopic concentration gradient is present across a binary mixture, long-ranged non-equilibrium concentration fluctuations (NCF) appear as a consequence of the coupling between the gradient and spontaneous equilibrium velocity fluctuations. Long-ranged equilibrium concentration fluctuations (ECF) may be also observed when the mixture is close to a critical point. Here we study the interplay between NCF and critical ECF in a near-critical mixture aniline/cyclohexane in the presence of a vertical concentration gradient...
October 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27777002/structural-basis-of-novel-iron-uptake-route-and-reaction-intermediates-in-ferritins-from-gram-negative-bacteria
#19
Sella Kim, Ji-Hye Lee, Jong Hyeon Seok, Yi-Ho Park, Sang Won Jung, Art E Cho, Cheolju Lee, Mi Sook Chung, Kyung Hyun Kim
Iron and oxygen chemistry is mediated by iron proteins for many biological functions. Carboxylate-bridged diiron enzymes including ferritin have the common mechanism of oxygen activation via peroxodiferric intermediates. However, the route for iron uptake and the structural identification of intermediates still remain incomplete. The 4-fold symmetry channel of Helicobacter pylori ferritin was previously proposed as the iron-uptake route in eubacteria, but the amino acid residues at the 4-fold channel are not highly conserved...
December 4, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27776843/histopathological-regression-after-neoadjuvant-docetaxel-oxaliplatin-fluorouracil-and-leucovorin-versus-epirubicin-cisplatin-and-fluorouracil-or-capecitabine-in-patients-with-resectable-gastric-or-gastro-oesophageal-junction-adenocarcinoma-flot4-aio-results
#20
Salah-Eddin Al-Batran, Ralf D Hofheinz, Claudia Pauligk, Hans-Georg Kopp, Georg Martin Haag, Kim Barbara Luley, Johannes Meiler, Nils Homann, Sylvie Lorenzen, Harald Schmalenberg, Stephan Probst, Michael Koenigsmann, Matthias Egger, Nicole Prasnikar, Karel Caca, Jörg Trojan, Uwe M Martens, Andreas Block, Wolfgang Fischbach, Rolf Mahlberg, Michael Clemens, Gerald Illerhaus, Katja Zirlik, Dirk M Behringer, Wolff Schmiegel, Michael Pohl, Michael Heike, Ulrich Ronellenfitsch, Martin Schuler, Wolf O Bechstein, Alfred Königsrainer, Timo Gaiser, Peter Schirmacher, Wael Hozaeel, Alexander Reichart, Thorsten O Goetze, Mark Sievert, Elke Jäger, Stefan Mönig, Andrea Tannapfel
BACKGROUND: Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma, but has not yet been evaluated in the context of resectable patients. Here we report findings from the phase 2 part of the phase 2/3 FLOT4 trial, which compared histopathological regression in patients treated with a docetaxel-based triplet chemotherapy versus an anthracycline-based triplet chemotherapy before surgical resection. METHODS: In this randomised, open-label, phase 2/3 study, eligible participants were recruited from 28 German oncology centres...
December 2016: Lancet Oncology
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