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https://www.readbyqxmd.com/read/28441858/-development-of-an-eosinophilic-bronchitis-mouse-model-and-the-effects-of-eosinophil-activation-on-airway-hyperresponsiveness-in-eosinophilic-bronchitis-mice
#1
L Li, J T Lin
Objective: To develop a mouse model of eosinophilic bronchitis, and explore the effects of eosinophil activation on airway hyperresponsiveness. Methods: A total of 60 female specific pathogen free BALB/c female mice were divided randomly into four groups: polymyxin B group, normal saline group, polymyxin B+ N-methionine leucine phenylalanine (fMLP) group, normal saline+ fMLP group. All the groups were given corresponding nasal drops for 21 days. The former two groups were given 12 μl 0.5% polymyxin B or normal saline once a day by transnasal administration respectively...
April 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28437060/high-throughput-and-quantitative-measurement-of-microbial-metabolome-by-gas-chromatography-mass-spectrometry-using-automated-alkyl-chloroformate-derivatization
#2
Linjing Zhao, Yan Ni, Mingming Su, Hongsen Li, Fangcong Dong, Wenlian Chen, Runmin Wei, Lulu Zhang, Seu-Ping Guiraud, François-Pierre J Martin, Cynthia Rajani, Guoxiang Xie, Wei Jia
The ability to identify and quantify small molecule metabolites derived from gut microbial-mammalian co-metabolism is essential for the understanding of the distinct metabolic functions of the microbiome. To date, analytical protocols that quantitatively measure a complete panel of microbial metabolites in biological samples have not been established, but urgently needed by the microbiome research community. Here, we report an automated high-throughput quantitative method using a gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) platform to simultaneously measure over one hundred microbial metabolites in human serum, urine, feces and Escherichia coli cell samples within 15 minutes per sample...
April 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28419323/monte-carlo-simulation-used-to-calculate-energy-correction-factor-for-thermoluminescent-dosimeters-used-by-occupational-workers-on-pediatric-exams
#3
G Hoff, D Filipov, S Paschuk, H R Schelin, V Denyak
The main objective of this work is to simulate the X-ray scattered spectra by different pediatric phantoms (simulation of children subjected to barium meal procedures) to calculate an energy correction factor (ECF) to the reading of thermoluminescent dosimeters (TLDs). To perform this evaluation, the TLDs were positioned over three areas in two occupational workers: eyes, thyroid and hands. The Geant4 toolkit was used to define the spectra collected by TLDs, making possible to calculate the ECF. This work was developed in two stages: (1) evaluation of scattered spectra by different standard phantoms (newborn, 1, 5 and 10 years old); (2) definition of the ECF to the absorbed energy by each TLD...
April 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28379281/regression-of-established-cardiac-fibrosis-in-hypertensive-heart-disease
#4
Karl T Weber, Yao Sun, Ivan C Gerling, Ramareddy V Guntaka
Established cardiac fibrosis (ECF) with symptomatic heart failure preserved ejection fraction represents an ever-increasing segment of the hypertensive population. The regression of ECF with attendant improvement in myocardial stiffness and symptomatic failure represents an unmet health care need. Is the regression of ECF in hypertensive heart disease feasible and will stiffness and symptomatic failure be improved? What is the cellular/molecular signaling involved in its regression? What incremental knowledge is needed to proceed effectively? These issues are addressed in this Review...
April 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28373014/the-combyn%C3%A2-ecg-adding-haemodynamic-and-fluid-leads-for-the-ecg-part-ii-prediction-of-total-body-water-tbw-extracellular-fluid-ecf-ecf-overload-fat-mass-fm-and-dry-appendicular-muscle-mass-appmm
#5
Falko Skrabal, Georg P Pichler, Mathias Penatzer, Johannes Steinbichl, Anna-Katharina Hanserl, Alfred Leis, Herbert Loibner
Simultaneous with a 12 channel ECG, body composition was analysed by segmental multi-frequency impedance analysis in 101 healthy subjects and in 118 patients with chronic heart failure (CHF, n= 40), chronic renal failure with haemodialysis (HD, n= 20), and miscellaneous internal diseases (n= 58). Whole body DXA and sodium bromide dilution were used as reference methods for total body water (TBW), extracellular fluid (ECF), appendicular muscle mass (AppMM) and fat mass (FM). Empirical prediction equations were developed in a randomized evaluation sample and then evaluated in unknowns...
March 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28366760/pilot-study-of-immunological-factors-in-non-inflammatory-bowel-disease-enterocutaneous-fistulas
#6
Goher Rahbour, Janindra Warusavitarne, Ailsa L Hart, Philip J Tozer, Mohammad R Ullah, Gregory P Thomas, Simon M Gabe, Stella C Knight, Hafid O Al-Hassi, Carolynne J Vaizey
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a cytokine elevated in inflammatory bowel disease enterocutaneous fistula (IBD ECF). Dendritic cells are antigen presenting cells that orchestrate the immune responses and regulate the production of cytokines by immune cells including T cells. No study to date has assessed the level of TNF-α or the presence of dendritic cells in non-IBD ECF. The aim of this study was to assess the inflammatory activity, with a particular emphasis on TNF-α in non-IBD ECF when compared with control small bowel tissue...
March 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28358595/treatment-of-enterocutaneous-fistulas-then-and-now
#7
Luis Alfonso Ortiz, Bin Zhang, Maureen Walsh McCarthy, Haytham M A Kaafarani, Peter Fagenholz, David R King, Marc De Moya, George Velmahos, Daniel Dante Yeh
BACKGROUND: An enterocutaneous fistula (ECF) is an aberrant connection between the gastrointestinal tract and the skin or atmosphere (enteroatmospheric fistula [EAF]). Multimodal treatment includes surgical procedures, nutrition support, and wound care. We evaluated our practice and compared our outcomes with previous results published from our institution. MATERIALS AND METHODS: We performed a retrospective analysis of hospitalized ECF/EAF patients admitted between January 2011 and November 2015...
March 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28337665/effect-of-efflux-transporter-inhibition-on-the-distribution-of-fluconazole-in-the-rat-brain
#8
Wei Wang, Na Zheng, Jiatang Zhang, Xusheng Huang, Shengyuan Yu
Multidrug resistance-associated proteins (MRPs) and organic anion transporters (OATs) are expressed on the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), preventing the entry of or the pumping out of numerous molecules. Fluconazole is widely used to treat fungal meningoencephalitis. The effect of these transporters on the distribution of fluconazole in the brain is unclear. We used microdialysis to compare the distribution of fluconazole in the rat brain with and without co-administration of probenecid, a MRP and OAT inhibitor...
March 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28337660/topgear-a-randomized-phase-iii-trial-of-perioperative-ecf-chemotherapy-with-or-without-preoperative-chemoradiation-for-resectable-gastric-cancer-interim-results-from-an-international-intergroup-trial-of-the-agitg-trog-eortc-and-cctg
#9
Trevor Leong, B Mark Smithers, Karin Haustermans, Michael Michael, Val Gebski, Danielle Miller, John Zalcberg, Alex Boussioutas, Michael Findlay, Rachel L O'Connell, Jaclyn Verghis, David Willis, Tomas Kron, Melissa Crain, William K Murray, Florian Lordick, Carol Swallow, Gail Darling, John Simes, Rebecca Wong
BACKGROUND: Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding preoperative chemoradiation to perioperative ECF will improve survival; however, the safety and feasibility of preoperative chemoradiation have yet to be determined. METHODS: TOPGEAR is an international phase III trial in which patients with adenocarcinoma of the stomach were randomized to perioperative ECF alone or with preoperative chemoradiation...
March 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28332070/a-review-on-prevalence-control-measure-and-tolerance-of-tanzania-shorthorn-zebu-cattle-to-east-coast-fever-in-tanzania
#10
E L K Laisser, S W Chenyambuga, E D Karimuribo, G Msalya, M J Kipanyula, A J Mwilawa, R H Mdegela, L J M Kusiluka
In Tanzania, control of East Coast fever (ECF) has predominantly relied on tick control using acaricides and chemotherapy, little on ECF vaccination, and very little on dissemination regarding animal immunization. In this paper, the prevalence, control measure, and tolerance of Tanzania Shorthorn Zebu (TSHZ) cattle to ECF are reviewed. In addition, the opportunities available for reducing the use of acaricides for the benefit of the farmers in terms of reduction of costs of purchasing acaricides and environmental pollution are described...
March 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28330304/elicitation-of-gymnemic-acid-production-in-cell-suspension-cultures-of-gymnema-sylvestre-r-br-through-endophytic-fungi
#11
Vasudeva Reddy Netala, Venkata Subbaiah Kotakadi, Susmila Aparna Gaddam, Sukhendu Bikash Ghosh, Vijaya Tartte
The enhancement of plant secondary metabolite production in cell suspension cultures through biotic or abiotic elicitation has become a potential biotechnological approach for commercialization or large-scale production of bioactive compounds. Gymnema sylvestre R.Br. is an important medicinal plant, rich in a group of oleanane triterpenoid saponins called gymnemic acid, well known for its anti-diabetic activity. Two endophytic fungal strains were isolated from the leaves of G. sylvestre and identified as Polyancora globosa and Xylaria sp...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323788/traumatic-colon-injury-in-damage-control-laparotomy-a-multicenter-trial-is-it-safe-to-do-a-delayed-anastomosis
#12
Leah Carey Tatebe, Andrew Jennings, Ken Tatebe, Alexandra Handy, Purvi Prajapati, Michael Smith, Tai Do, Gerald O Ogola, Rajesh R Gandhi, Therese M Duane, Stephen Luk, Laura Bruce Petrey
BACKGROUND: Delayed colonic anastomosis after damage control laparotomy (DCL) is an alternative to colostomies during a single laparotomy (SL) in high-risk patients. However, literature suggests increased colonic leak rates up to 27% with DCL, and various reported risk factors. We evaluated our regional experience to determine if delayed colonic anastomosis was associated with worse outcomes. METHODS: A multicenter retrospective cohort study was performed across three Level I trauma centers encompassing traumatic colon injuries from January 2006 through June 2014...
April 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28322252/structure-and-mechanism-of-a-group-i-cobalt-energy-coupling-factor-transporter
#13
Zhihao Bao, Xiaofeng Qi, Sen Hong, Ke Xu, Fangyuan He, Minhua Zhang, Jiugeng Chen, Daiyin Chao, Wei Zhao, Dianfan Li, Jiawei Wang, Peng Zhang
Energy-coupling factor (ECF) transporters are a large family of ATP-binding cassette transporters recently identified in microorganisms. Responsible for micronutrient uptake from the environment, ECF transporters are modular transporters composed of a membrane substrate-binding component EcfS and an ECF module consisting of an integral membrane scaffold component EcfT and two cytoplasmic ATP binding/hydrolysis components EcfA/A'. ECF transporters are classified into groups I and II. Currently, the molecular understanding of group-I ECF transporters is very limited, partly due to a lack of transporter complex structural information...
March 21, 2017: Cell Research
https://www.readbyqxmd.com/read/28321590/extreme-climatic-conditions-and-health-service-utilisation-across-rural-and-metropolitan-new-south-wales
#14
Edward Jegasothy, Rhydwyn McGuire, John Nairn, Robert Fawcett, Benjamin Scalley
Periods of successive extreme heat and cold temperature have major effects on human health and increase rates of health service utilisation. The severity of these events varies between geographic locations and populations. This study aimed to estimate the effects of heat waves and cold waves on health service utilisation across urban, regional and remote areas in New South Wales (NSW), Australia, during the 10-year study period 2005-2015. We divided the state into three regions and used 24 over-dispersed or zero-inflated Poisson time-series regression models to estimate the effect of heat waves and cold waves, of three levels of severity, on the rates of ambulance call-outs, emergency department (ED) presentations and mortality...
March 20, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28301212/the-use-of-latex-catheters-to-close-enterocutaneous-fistulas-an-institutional-protocol-and-retrospective-review
#15
Shamar Young, Donna D'Souza, David Hunter, Jafar Golzarian, Michael Rosenberg
OBJECTIVE: The objective of our study was to retrospectively review an institutional protocol that uses latex catheters for the treatment of enterocutaneous fistulas (ECFs) that are resistant to simple drainage. MATERIALS AND METHODS: Forty-six consecutive patients with ECFs that did not close with simple abscess drainage were treated with latex catheters. These patients' charts were retrospectively reviewed to determine treatment success rates and the relationship of treatment success to clinical characteristics...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28295534/mucin-rich-variant-of-traditional-serrated-adenoma-mrtsa-a-distinct-morphological-variant
#16
Sangeetha N Kalimuthu, Stefano Serra, Sara Hafezi-Bakhtiari, Richard Colling, Lai Mun Wang, Runjan Chetty
Traditional serrated adenomas (TSAs) account for 5% of serrated polyps, have villiform architecture, eosinophilic cells with a brush border and indented, flat-topped luminal serrations. However, some are composed of mucin-filled goblet cells (GC): a mucin-rich variant (MrTSA). The aim of this study was to determine if this variant has unique features compared to classic TSA (cTSA). 156 TSAs were retrieved from 2010-2016. Patient demographics, site of polyps, and 16 microscopic variables, were evaluated. TSAs containing 50% or more GCs were classified as MrTSAs...
March 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28251873/mix-and-matching-as-a-promoter-recognition-mechanism-by-ecf-%C3%AF-factors
#17
Jelena Guzina, Marko Djordjevic
BACKGROUND: Transcription initiation is in bacteria exhibited by different σ factors, most of which fall within σ(70) family. This family is diverse, ranging from the housekeeping Group I (RpoDs), to Group IV (ECF) σ factors, that transcribe smaller regulons under more stringent conditions. RpoDs employ a kinetic mix-and-match mechanism, where promoter elements complement each other binding strengths in achieving sufficient transcription activity. On the other hand, it is assumed that ECF σs, which are the most distant from the housekeeping σ factors, cannot exhibit mix-and-matching...
February 7, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28231338/genes-encoding-two-theileria-parva-antigens-recognized-by-cd8-t-cells-exhibit-sequence-diversity-in-south-sudanese-cattle-populations-but-the-majority-of-alleles-are-similar-to-the-muguga-component-of-the-live-vaccine-cocktail
#18
Diaeldin A Salih, Roger Pelle, Joram M Mwacharo, Moses N Njahira, Wani L Marcellino, Henry Kiara, Agol K Malak, Abdel Rahim M El Hussein, Richard Bishop, Robert A Skilton
East Coast fever (ECF), caused by Theileria parva infection, is a frequently fatal disease of cattle in eastern, central and southern Africa, and an emerging disease in South Sudan. Immunization using the infection and treatment method (ITM) is increasingly being used for control in countries affected by ECF, but not yet in South Sudan. It has been reported that CD8+ T-cell lymphocytes specific for parasitized cells play a central role in the immunity induced by ITM and a number of T. parva antigens recognized by parasite-specific CD8+ T-cells have been identified...
2017: PloS One
https://www.readbyqxmd.com/read/28209392/transfer-of-do-not-resuscitate-orders-to-the-emergency-department-from-extended-care-facilities
#19
Colleen M McQuown, Jennifer A Frey, Ahmad Amireh, Ali Chaudhary
PURPOSE/OBJECTIVE: With an elderly and chronically ill patient population visiting the emergency department, it is important to know patients' wishes regarding care preferences and advanced directives. Ohio law states DNR orders must be transported with the patient when they leave an extended care facility (ECF). We reviewed the charts of ECF patients to evaluate which patients presenting to the ED had their DNR status recognized by the physician and DNR orders that were made during their hospital stay...
February 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28193369/-expressed-emotions-burden-and-family-functioning-in-schizophrenic-and-bipolar-i-patients-of-a-multimodal-intervention-program-prisma
#20
Alexandra Ramírez, Juan David Palacio, Cristian Vargas, Ana María Díaz-Zuluaga, Kelly Duica, Yuli Agudelo Berruecos, Sigifredo Ospina, Carlos López-Jaramillo
INTRODUCTION: Bipolar disorder and schizophrenia are causes of major suffering in patients. Nevertheless, they also affect family and caregiver functioning. This is important because the participation and involvement of families and caregivers is essential to achieve an optimal treatment. OBJECTIVE: To describe the level of expressed emotions, burden, and family functioning of bipolar and schizophrenic patients and, to evaluate the efficacy of the multimodal intervention (MI) versus traditional intervention (TI) in family functioning and its perception by patients and caregivers...
January 2017: Revista Colombiana de Psiquiatría
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