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https://www.readbyqxmd.com/read/27913762/aspen-felanpe-clinical-guidelines-nutrition-support-of-adult-patients-with-enterocutaneous-fistula
#1
Vanessa J Kumpf, Jose Eduardo de Aguilar-Nascimento, Jose Ignacio Diaz-Pizarro Graf, Amber M Hall, Liam McKeever, Ezra Steiger, Marion F Winkler, Charlene W Compher
BACKGROUND: The management of patients with enterocutaneous fistula (ECF) requires an interdisciplinary approach and poses a significant challenge to physicians, wound/stoma care specialists, dietitians, pharmacists, and other nutrition clinicians. Guidelines for optimizing nutrition status in these patients are often vague, based on limited and dated clinical studies, and typically rely on individual institutional or clinician experience. Specific nutrient requirements, appropriate route of feeding, role of immune-enhancing formulas, and use of somatostatin analogues in the management of patients with ECF are not well defined...
December 2, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27893673/risk-factor-and-outcome-for-intra-abdominal-bleeding-in-patients-with-enterocutaneous-fistula
#2
Lei Wu, Jianan Ren, Qinjie Liu, Gefei Wang, Xiuwen Wu, Guosheng Gu, Guanwei Li, Kun Guo, Zhiwu Hong, Qiongyuan Hu, Huajian Ren, Jieshou Li
Intra-abdominal bleeding is a major and lethal complication in patients with enterocutaneous fistula (ECF) while few studies are involved in this aspect. In the present study, we aimed to investigate the risk factors and assessed the outcome for intra-abdominal bleeding in patients with ECF.A retrospective study was performed from October 2013 to October 2015. Medical records of 67 ECF patients with intra-abdominal bleeding and 134 ECF patients without intra-abdominal bleeding matched as controls were reviewed and analyzed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27873747/atypical-presentation-of-appendicitis
#3
Oliver Beaumont, Robert Miller, Richard Guy
A woman aged 64 years presented as an emergency with a mass in the right iliac fossa, clinically within the abdominal wall, but an otherwise soft abdomen. Systemically, she was quite well with normal vital signs. Blood tests revealed raised inflammatory markers, and an abdominal CT scan demonstrated a perforated appendix with associated large subcutaneous abscess. This represents a rare presentation of a common condition, demonstrating how appendicitis can still be a challenging problem for the clinician...
November 10, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27866464/endometriotic-cyst-fluid-induces-reactive-oxygen-species-ros-in-human-immortalized-epithelial-cells-derived-from-ovarian-endometrioma
#4
Yoichi Kobayashi, Kiyono Osanai, Kei Tanaka, Yoshiko Nishigaya, Hironori Matsumoto, Mai Momomura, Masamichi Hashiba, Shizuka Mita, Satoru Kyo, Mitsutoshi Iwashita
OBJECTIVES: Endometriotic cyst fluid (ECF) contains a large amount of reactive oxygen species (ROS), and endometriotic cysts are exposed to strong oxidative stress, which may cause malignant transformation. In this study, ROS production by ECF was clinically analysed. METHODS: Human immortalized epithelial cells derived from ovarian endometrioma (EMosis-CC/TERT 1) were treated with ECF. In addition, ROS production in EMosis-CC/TERT 1 was measured, and its clinical significance was analysed...
November 20, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27847669/novel-approach-for-enterocutaneous-fistula-treatment-with-the-use-of-viable-cryopreserved-placental-membrane
#5
Frederick Nichols, Aaron Overly
Enterocutaneous fistulas (ECF) are a difficult and costly surgical complication to manage. The standard treatment of nil per os (NPO) and total paraenteral nutrition (TPN) is not well tolerated by patients. TPN is also known for complications associated with long term central venous catheterization and for high cost of prolonged hospital stay. We present two low output ECF cases successfully treated with viable cryopreserved placental membrane (vCPM) placed into the fistula tracts. One patient is a 59-year-old male with a low output ECF from a jejunostomy tube site four weeks after the surgery...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27808443/evaluating-the-potential-of-effluent-extracts-from-pulp-and-paper-mills-in-canada-brazil-and-new-zealand-to-affect-fish-reproduction-estrogenic-effects-in-fish
#6
Rodrigo Orrego, Craig B Milestone, L Mark Hewitt, John Guchardi, Tatiana Heid-Furley, Alison Slade, Deborah L MacLatchy, Douglas Holdway
This study examined the potential of pulp mill effluent from pulp producing countries (Canada, Brazil, New Zealand) to affect fish reproduction. Specifically, the estrogenic effects in juvenile rainbow trout (Oncorhynchus mykiss) pulse-exposed to 11 different mill effluent extracts (intra peritoneal IP-injections of SPE-DCM non-polar fraction). The results indicated that effluent extracts were estrogenic in juvenile trout irrespective of the gender, reflected by increasing level of plasma vitellogenin (VTG) (Brazil > New Zealand > Canada)...
November 3, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27796702/equilibrium-and-non-equilibrium-concentration-fluctuations-in-a-critical-binary-mixture
#7
Fabio Giavazzi, Alessandro Fornasieri, Alberto Vailati, Roberto Cerbino
When a macroscopic concentration gradient is present across a binary mixture, long-ranged non-equilibrium concentration fluctuations (NCF) appear as a consequence of the coupling between the gradient and spontaneous equilibrium velocity fluctuations. Long-ranged equilibrium concentration fluctuations (ECF) may be also observed when the mixture is close to a critical point. Here we study the interplay between NCF and critical ECF in a near-critical mixture aniline/cyclohexane in the presence of a vertical concentration gradient...
October 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27777002/structural-basis-of-novel-iron-uptake-route-and-reaction-intermediates-in-ferritins-from-gram-negative-bacteria
#8
Sella Kim, Ji-Hye Lee, Jong Hyeon Seok, Yi-Ho Park, Sang Won Jung, Art E Cho, Cheolju Lee, Mi Sook Chung, Kyung Hyun Kim
Iron and oxygen chemistry is mediated by iron proteins for many biological functions. Carboxylate-bridged diiron enzymes including ferritin have in common the mechanism of oxygen activation via peroxodiferric intermediates. However, the route for iron uptake and the structural identification of intermediates still remain incomplete. The 4-fold symmetry channel of Helicobacter pylori ferritin (Hpf) was previously proposed as the iron uptake route in eubacteria, but the amino acid residues at the 4-fold channel are not highly conserved...
October 21, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27776843/histopathological-regression-after-neoadjuvant-docetaxel-oxaliplatin-fluorouracil-and-leucovorin-versus-epirubicin-cisplatin-and-fluorouracil-or-capecitabine-in-patients-with-resectable-gastric-or-gastro-oesophageal-junction-adenocarcinoma-flot4-aio-results
#9
Salah-Eddin Al-Batran, Ralf D Hofheinz, Claudia Pauligk, Hans-Georg Kopp, Georg Martin Haag, Kim Barbara Luley, Johannes Meiler, Nils Homann, Sylvie Lorenzen, Harald Schmalenberg, Stephan Probst, Michael Koenigsmann, Matthias Egger, Nicole Prasnikar, Karel Caca, Jörg Trojan, Uwe M Martens, Andreas Block, Wolfgang Fischbach, Rolf Mahlberg, Michael Clemens, Gerald Illerhaus, Katja Zirlik, Dirk M Behringer, Wolff Schmiegel, Michael Pohl, Michael Heike, Ulrich Ronellenfitsch, Martin Schuler, Wolf O Bechstein, Alfred Königsrainer, Timo Gaiser, Peter Schirmacher, Wael Hozaeel, Alexander Reichart, Thorsten O Goetze, Mark Sievert, Elke Jäger, Stefan Mönig, Andrea Tannapfel
BACKGROUND: Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma, but has not yet been evaluated in the context of resectable patients. Here we report findings from the phase 2 part of the phase 2/3 FLOT4 trial, which compared histopathological regression in patients treated with a docetaxel-based triplet chemotherapy versus an anthracycline-based triplet chemotherapy before surgical resection. METHODS: In this randomised, open-label, phase 2/3 study, eligible participants were recruited from 28 German oncology centres...
October 21, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27756520/prevalence-and-clinical-significance-of-extracardiac-findings-in-cardiovascular-magnetic-resonance
#10
Agne Ulyte, Nomeda Valeviciene, Darius Palionis, Simona Kundrotaite, Algirdas Tamosiunas
OBJECTIVE: In cardiac magnetic resonance imaging (CMR), incidental pathological findings are frequently found outside the investigated cardiovascular system. Some of these findings might have clinical implications. The aim of this study was to determine the prevalence of incidental extracardiac findings (ECF) in CMR and their clinical significance. METHODS: A total of 4165 CMR reports from 2009-2012 were retrospectively reviewed for ECF. Two hundred-twenty reports with ECF were found...
September 22, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27740595/how-glutamate-is-managed-by-the-blood-brain-barrier
#11
Richard A Hawkins, Juan R Viña
A facilitative transport system exists on the blood-brain barrier (BBB) that has been tacitly assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential amino acid whose brain content is much greater than plasma, and studies in vivo show that glutamate does not enter the brain in appreciable quantities except in those small regions with fenestrated capillaries (circumventricular organs). The situation became understandable when luminal (blood facing) and abluminal (brain facing) membranes were isolated and studied separately...
October 8, 2016: Biology
https://www.readbyqxmd.com/read/27704189/sublethal-effects-of-chlorine-free-kraft-mill-effluents-on-daphnia-magna
#12
Soledad Chamorro, Daniela López, Pablina Brito, Mayra Jarpa, Benjamin Piña, Gladys Vidal
The implementation of elemental chlorine-free (ECF) bleaching methods has drastically reduced the aquatic toxicity of Kraft mill effluents during the last decade. However, the residual toxicity of Kraft mill effluents is still a potential concern for the environment, even when subjected to secondary wastewater treatment. The aim of this study is characterize potential sublethal effects of ECF Kraft mill effluents using Daphnia magna as model species. D. magna exposed towards increasing concentration of ECF Kraft mill effluent showed a significant, dose-dependent reduction in feeding...
December 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27700998/coagulation-flocculation-as-pre-treatment-for-micro-scale-fe-cu-o3-process-cf-mfe-cu-o3-treatment-of-the-coating-wastewater-from-automobile-manufacturing
#13
Zhaokun Xiong, Jinyan Cao, Dan Yang, Bo Lai, Ping Yang
A coagulation-flocculation as pre-treatment combined with mFe/Cu/O3 (CF-mFe/Cu/O3) process was developed to degrade the pollutants in automobile coating wastewater (ACW). In coagulation-flocculation (CF) process, high turbidity removal efficiency (97.1%) and low COD removal efficiency (10.5%) were obtained under the optimal conditions using Al2(SO4)3·18H2O and CaO. The effluent of CF process (ECF) was further disposed by mFe/Cu/O3 process, and its key operating parameters were optimized by batch experiments...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27684739/suppression-of-abnormal-morphology-and-extracytoplasmic-function-sigma-activity-in-bacillus-subtilis-ugtp-mutant-cells-by-expression-of-heterologous-glucolipid-synthases-from-acholeplasma-laidlawii
#14
Satoshi Matsuoka, Takahiro Seki, Kouji Matsumoto, Hiroshi Hara
Glucolipids in Bacillus subtilis are synthesized by UgtP processively transferring glucose from UDP-glucose to diacylglycerol. Here we conclude that the abnormal morphology of a ugtP mutant is caused by lack of glucolipids, since the same morphology arises after abolition of glucolipid production by disruption of pgcA and gtaB, which are involved in UDP-glucose synthesis. Conversely, expression of a monoglucosyldiacylglycerol (MGlcDG) produced by 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii (alMGS) almost completely suppressed the ugtP disruptant phenotype...
December 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27673568/intrarater-reliability-of-tonometry-and-bioimpedance-spectroscopy-to-measure-tissue-compressibility-and-extracellular-fluid-in-the-legs-of-healthy-young-people-in-australia-and-myanmar
#15
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Measurements of tissue compressibility and extracellular fluid (ECF) are used to monitor progression of lymphedema, a chronic swelling of the subcutaneous tissue. Later stages of lymphedema are characterized by fibrotic induration in the subcutis and hyperkeratosis of the skin. Several devices are available to measure these changes, but previous reliability and validity studies have been conducted primarily on adult women with unilateral arm lymphedema using contralateral limbs as controls...
September 27, 2016: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/27603112/binding-of-pollutants-to-biomolecules-a-simulation-study
#16
Ahmet Yildirim, Jin Zhang, Sergio Manzetti, David van der Spoel
A number of cases around the world have been reported where animals were found dead or dying with symptoms resembling a thiamine (vitamin B) deficiency, and for some of these, a link to pollutants has been suggested. Here, we investigate whether biomolecules involved in thiamin binding and transport could be blocked by a range of different pollutants. We used in silico docking of five compound classes (25 compounds in total) to each of five targets (prion protein, ECF-type ABC transporter, thi-box riboswitch receptor, thiamin pyrophosphokinase, and YKoF protein) and subsequently performed molecular dynamics (MD) simulations to assess the stability of the complexes...
October 17, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27603006/distribution-of-extracellular-fluid-in-legs-with-venous-edema-and-lymphedema
#17
Kotaro Suehiro, Noriyasu Morikage, Osamu Yamashita, Takasuke Harada, Koshiro Ueda, Makoto Samura, Yuya Tanaka, Yuriko Takeuchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: This study aimed to determine the specific fluid distribution pattern in legs with lymphedema (LE) in comparison to normal legs and legs with venous edema (VE) using bioelectrical impedance analysis (BIA). METHODS AND RESULTS: BIA was performed in 47 patients with lymphedema (LE; 63 legs), 33 patients with venous edema (VE; 60 legs), and 33 normal subjects (N; 66 legs). The ratio of intracellular fluid (ICF) resistance (Ri) to extracellular fluid (ECF) resistance (Re) of a whole leg normalized to the right arm (Ri/Re leg), a surrogate parameter for ECF/ICF, and the Ri/Re of the thigh and calf without normalization (Ri/Re thigh, Ri/Re calf, respectively) were obtained...
September 2016: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/27602573/the-anti-sigma-factor-rsiv-is-a-bacterial-receptor-for-lysozyme-co-crystal-structure-determination-and-demonstration-that-binding-of-lysozyme-to-rsiv-is-required-for-%C3%AF-v-activation
#18
Jessica L Hastie, Kyle B Williams, Lindsey L Bohr, Jon C Houtman, Lokesh Gakhar, Craig D Ellermeier
σ factors provide RNA polymerase with promoter specificity in bacteria. Some σ factors require activation in order to interact with RNA polymerase and transcribe target genes. The Extra-Cytoplasmic Function (ECF) σ factor, σV, is encoded by several Gram-positive bacteria and is specifically activated by lysozyme. This activation requires the proteolytic destruction of the anti-σ factor RsiV via a process of regulated intramembrane proteolysis (RIP). In many cases proteases that cleave at site-1 are thought to directly sense a signal and initiate the RIP process...
September 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27589998/induction-of-humoral-immune-response-to-multiple-recombinant-rhipicephalus-appendiculatus-antigens-and-their-effect-on-tick-feeding-success-and-pathogen-transmission
#19
Cassandra L Olds, Stephen Mwaura, David O Odongo, Glen A Scoles, Richard Bishop, Claudia Daubenberger
BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect feeding success and possibly reduce tick-borne transmission of T. parva. Here we report the evaluation of a multivalent vaccine cocktail of tick antigens for their ability to reduce R. appendiculatus feeding success and possibly reduce tick-transmission of T...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27586904/condensed-phase-qm-mm-simulations-utilizing-the-exchange-core-functions-to-describe-exchange-repulsions-at-the-qm-boundary-region
#20
Satoru Umino, Hideaki Takahashi, Akihiro Morita
In a recent work, we developed a method [H. Takahashi et al., J. Chem. Phys. 143, 084104 (2015)] referred to as exchange-core function (ECF) approach, to compute exchange repulsion Eex between solute and solvent in the framework of the quantum mechanical (QM)/molecular mechanical (MM) method. The ECF, represented with a Slater function, plays an essential role in determining Eex on the basis of the overlap model. In the work of Takahashi et al. [J. Chem. Phys. 143, 084104 (2015)], it was demonstrated that our approach is successful in computing the hydrogen bond energies of minimal QM/MM systems including a cationic QM solute...
August 28, 2016: Journal of Chemical Physics
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