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https://www.readbyqxmd.com/read/29691262/predicting-medication-adherence-in-older-hispanic-patients-with-type-2-diabetes
#1
Joshua Caballero, Raymond L Ownby, Robin J Jacobs, Naushira Pandya, Patrick C Hardigan, Lazara C Ricabal
PURPOSE: Potential cognitive and demographic correlates of medication nonadherence in older Hispanic adults with type 2 diabetes were investigated. METHODS: Forty community-dwelling participants 65 years of age or older were recruited. Executive control function (ECF) was assessed using the executive clock drawing task (CLOX 1) test and the 25-item Executive Interview. Self-reported medication adherence was measured on a visual analog scale (VAS); measures of glycemic control included glycosylated hemoglobin (HbA1c ) concentration...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29678234/antibodies-to-in-silico-selected-gpi-anchored-theileria-parva-proteins-neutralize-sporozoite-infection-in-vitro
#2
James Nyagwange, Vishvanath Nene, Stephen Mwalimu, Sonal Henson, Lucilla Steinaa, Benjamin Nzau, Edwin Tijhaar, Roger Pelle
East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with a long-acting oxytetracycline. Although effective, this method has serious limitations; the immunity is parasite strain specific and immunized cattle can become life-long asymptomatic carriers of the parasite, posing risk for the spread of the disease...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29600225/comparison-of-health-related-quality-of-life-with-epirubicin-cisplatin-plus-5-fluorouracil-and-docetaxel-cisplatin-plus-5-fluorouracil-chemotherapy-regimens-as-first-line-systemic-therapy-in-locally-advanced-inoperable-or-metastatic-gastric-or-gastro-esophageal
#3
K Govind Babu, Tamojit Chaudhuri, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev
Background: Health-related quality of life (HRQOL) is an important oncologic end point for upper gastrointestinal malignancies. Unfortunately, till date, there is no published prospective data from India, comparing the HRQOL parameters between first-line chemotherapy regimens in advanced/metastatic gastric cancer. Materials and Methods: The present study aimed to compare the HRQOL of first-line systemic chemotherapy with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens in patients with locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29597231/physiology-of-the-calcium-parathyroid-hormone-vitamin-d-axis
#4
David Goltzman, Michael Mannstadt, Claudio Marcocci
Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing receptor (CaSR) on the parathyroid cells, leading to an increase in intracellular calcium. This in turn leads to a reduced parathyroid hormone (PTH) release. Hypocalcemia leads to the opposite sequence of events, namely, lowered intracellular calcium and increased PTH production and secretion. PTH rapidly increases renal calcium reabsorption and, over hours to days, enhances osteoclastic bone resorption and liberates both calcium and phosphate from the skeleton...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29559674/executive-control-processes-are-associated-with-individual-fitness-outcomes-following-regular-exercise-training-blood-lactate-profile-curves-and-neuroimaging-findings
#5
M C Pensel, M Daamen, L Scheef, H U Knigge, S Rojas Vega, J A Martin, H H Schild, H K Strüder, H Boecker
Cardiovascular training has been associated with neuroimaging correlates of executive control functions (ECF) in seniors and children/adolescents, while complementary studies in middle-aged populations are lacking. Ascribing a prominent role to cardiorespiratory fitness improvements, most studies concentrated on training-induced gains in maximal oxygen uptake (VO2 max), although other fitness indices may provide complementary information. Here, we investigated the impact of long-term sub-maximal exercise training on interference control, considering individual training-induced shifts in blood lactate profile curves (BLC) and VO2 max...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29534988/genetic-diversity-and-population-structure-of-theileria-parva-in-south-sudan
#6
Diaeldin A Salih, Joram M Mwacharo, Roger Pelle, Moses N Njahira, David O Odongo, Mary N Mbole-Kariuki, Wani L Marcellino, Agol K Malak, Henary Kiara, Abdel Rahim M El Hussein, Richard P Bishop, Robert A Skilton
Theileria parva is a parasitic protozoan that causes East Coast fever (ECF), an economically important disease of cattle in eastern, central and southern Africa. In South Sudan, ECF is considered a major constraint for livestock development in regions where the disease is endemic. To obtain insights into the dynamics of T. parva in South Sudan, population genetic analysis was performed. Out of the 751 samples included in this study, 178 blood samples were positive for T. parva by species-specific PCR, were collected from cattle from four regions in South Sudan (Bor = 62; Juba = 45; Kajo keji = 41 and Yei = 30) were genotyped using 14 microsatellite markers spanning the four chromosomes...
March 3, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29523777/intracellular-desmoglein-2-cleavage-sensitizes-epithelial-cells-to-apoptosis-in-response-to-pro-inflammatory-cytokines
#7
Mark Yulis, Miguel Quiros, Roland Hilgarth, Charles A Parkos, Asma Nusrat
Desmosomal cadherins mediate intercellular adhesion and have also been shown to regulate homeostatic signaling in epithelial cells. We have previously reported that select pro-inflammatory cytokines induce Dsg2 ectodomain cleavage and shedding from intestinal epithelial cells (IECs). Dsg2 extracellular cleaved fragments (Dsg2 ECF) function to induce paracrine pro-proliferative signaling in epithelial cells. In this study, we show that exposure of IECs to pro-inflammatory cytokines interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) resulted in Dsg2 intracellular cleavage and generation of a ~55 kDa fragment (Dsg2 ICF)...
March 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29515563/the-sco4117-ecf-sigma-factor-pleiotropically-controls-secondary-metabolism-and-morphogenesis-in-streptomyces-coelicolor
#8
María T López-García, Paula Yagüe, Nathaly González-Quiñónez, Beatriz Rioseras, Angel Manteca
Extracytoplasmic function (ECF) sigma factors are a major type of bacterial signal-transducers whose biological functions remain poorly characterized in streptomycetes. In this work we studied SCO4117, a conserved ECF sigma factor from the ECF52 family overexpressed during substrate and aerial mycelium stages. The ECF52 sigma factors harbor, in addition to the ECF sigma factor domain, a zinc finger domain, a transmembrane region, a proline-rich C-terminal extension, and a carbohydrate-binding domain. This class of ECF sigma factors is exclusive to Actinobacteria...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29506920/ecfs-best-practice-guidelines-the-2018-revision
#9
REVIEW
Carlo Castellani, Alistair J A Duff, Scott C Bell, Harry G M Heijerman, Anne Munck, Felix Ratjen, Isabelle Sermet-Gaudelus, Kevin W Southern, Jurg Barben, Patrick A Flume, Pavla Hodková, Nataliya Kashirskaya, Maya N Kirszenbaum, Sue Madge, Helen Oxley, Barry Plant, Sarah Jane Schwarzenberg, Alan R Smyth, Giovanni Taccetti, Thomas O F Wagner, Susan P Wolfe, Pavel Drevinek
Developments in managing CF continue to drive dramatic improvements in survival. As newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of patients who have minimal lung disease on diagnosis. With the introduction of mutation-specific therapies and the prospect of truly personalised medicine, patients have the potential to enjoy good quality of life in adulthood with ever-increasing life expectancy. The landmark Standards of Care published in 2005 set out what high quality CF care is and how it can be delivered throughout Europe...
March 2, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29505144/computed-tomography-measured-psoas-density-predicts-outcomes-after-enterocutaneous-fistula-repair
#10
Wilson D Lo, David C Evans, Taehwan Yoo
BACKGROUND: Low muscle mass and quality are associated with poor surgical outcomes. We evaluated computed tomography (CT)-measured psoas muscle density as a marker of muscle quality and physiologic reserve and hypothesized that it predicts poor outcomes after enterocutaneous fistula repair (ECF). METHODS: We conducted a retrospective cohort study of patients 18-90 years old with ECF who failed nonoperative management, requiring elective operative repair at The Ohio State University (2005-2016), and who received preoperative abdomen/pelvis CT scan with intravenous contrast within 3 months of the operation...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29499743/rhipicephalus-appendiculatus-ticks-transmit-theileria-parva-from-persistently-infected-cattle-in-the-absence-of-detectable-parasitemia-implications-for-east-coast-fever-epidemiology
#11
Cassandra L Olds, Kathleen L Mason, Glen A Scoles
BACKGROUND: East Coast fever (ECF) is a devastating disease of cattle and a significant constraint to improvement of livestock production in sub-Saharan Africa. The protozoan parasite causing ECF, Theileria parva, undergoes obligate sexual stage development in its tick vector Rhipicephalus appendiculatus. Tick-borne acquisition and transmission occurs transstadially; larval and nymphal ticks acquire infection while feeding and transmit to cattle when they feed after molting to the next stage...
March 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29494744/day-of-surgery-affects-length-of-hospitalization-for-patients-undergoing-total-joint-arthroplasty-discharged-to-extended-care-facilities
#12
Ryan Lilly, Matthew Siljander, Denise M Koueiter, James Verner
Although the average hospital length of stay (LOS) after total joint arthroplasty (TJA) has decreased during the past 10 years, it continues to play a significant role in postoperative costs. The purpose of this study was to determine the effect of surgical day of the week on hospital LOS among TJA patients discharged to an extended care facility (ECF). A TJA database from a single hospital was used to identify all patients who underwent primary total knee arthroplasty (TKA) and total hip arthroplasty (THA) between January 2013 and December 2016...
March 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29488354/xanthomonas-citri-t6ss-mediates-resistance-to-dictyostelium-predation-and-is-regulated-by-an-ecf-%C3%AF-factor-and-cognate-ser-thr-kinase
#13
Ethel Bayer-Santos, Lidia Dos Passos Lima, Lucas de Moraes Ceseti, Camila Yuri Ratagami, Eliane Silva de Santana, Aline Maria da Silva, Chuck Shaker Farah, Cristina Elisa Alvarez-Martinez
Plant-associated bacteria of the genus Xanthomonas cause disease in a wide range of economically important crops. However, their ability to persist in the environment is still poorly understood. Predation by amoebas represent a major selective pressure to bacterial populations in the environment. In this study, we show that the X. citri type 6 secretion system (T6SS) promotes resistance to predation by the soil amoeba Dictyostelium discoideum. We found that an extracytoplasmic function (ECF) sigma factor (EcfK) is required for induction of T6SS genes during interaction with Dictyostelium...
February 28, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29485847/designing-recognition-molecules-and-tailoring-functional-surfaces-for-in-vivo-monitoring-of-small-molecules-in-the-brain
#14
Limin Zhang, Yang Tian
The in vivo analysis of chemical signals in brain extracellular fluid (ECF) using implanted electrochemical biosensors is a vital way to study brain functions and brain activity mapping. This approach offers excellent spatial (10-200 μm) and temporal (approximately second) resolution and the major advantage of long-term stability. By implantation of a microelectrode in a specific brain region, changes in the concentration of a variety of ECF chemical species can be monitored through applying a suitable electrical signal and, typically, recording the resulting Faradaic current...
February 27, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29479157/exploring-knowledge-and-management-practices-on-ticks-and-tick-borne-diseases-among-agro-pastoral-communities-in-southern-highlands-tanzania
#15
Isack Ibrahim Kerario, Martin Simuunza, Emmanuel L K Laisser, Sebastian Chenyambuga
Aim: The current study was conducted to assess the farmers' knowledge and management practices on ticks and tick-borne diseases (TBDs) through individual interview using a structured questionnaire in Mbarali and Momba districts of Mbeya region. Materials and Methods: A total of 240 households, 120 from each district were asked to mention TBDs of cattle which they thought were the most important in their localities and period of the year when the diseases occurred more frequently...
January 2018: Veterinary World
https://www.readbyqxmd.com/read/29455876/laser-ablation-facilitates-closure-of-chronic-enterocutaneous-fistulae
#16
Ravi N Srinivasa, Rajiv N Srinivasa, Joseph J Gemmete, Anthony N Hage, William Sherk, Jeffrey Forris Beecham Chick
This report describes the use of laser ablation for treatment of chronic enterocutaneous fistulae (ECFs) after failure of conservative therapy. Three patients underwent laser ablation for treatment of 8 ECFs. Mean duration of fistula patency was 28 months with mean fistula output of 134 mL/day. The initial technical success was 100% with no major or minor complications. Three ECFs required repeat treatment. At mean follow-up of 53 days, 7 of the fistulae were occluded. One fistula showed a markedly reduced output of 10 mL/day...
March 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29448989/redefining-bowel-regimen-pharmacologic-strategies-and-nutritional-considerations-in-the-management-of-small-bowel-fistulas
#17
REVIEW
Sara E Parli, Carolyn Pfeifer, Douglas R Oyler, Barbara Magnuson, Levi D Procter
Enterocutaneous fistulae (ECF) and enteroatmospheric fistulae (EAF) are difficult complications that primarily arise after abdominal surgical procedures. Development of an ECF or EAF carries significant mortality and morbidity. Effective management of patients with these disease states requires a multidisciplinary approach, which includes surgical, pharmacotherapeutic, and nutritional interventions. This review focuses on the medical and nutritional management of ECF/EAF, providing background on drug agents and nutritional strategies that may be helpful in reducing effluent volume, optimizing fistula healing, and maintaining nutritional health...
February 12, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29438446/a-thioredoxin-dependent-peroxiredoxin-q-from-corynebacterium-glutamicum-plays-an-important-role-in-defense-against-oxidative-stress
#18
Tao Su, Meiru Si, Yunfeng Zhao, Yan Liu, Shumin Yao, Chengchuan Che, Can Chen
Peroxiredoxin Q (PrxQ) that belonged to the cysteine-based peroxidases has long been identified in numerous bacteria, but the information on the physiological and biochemical functions of PrxQ remain largely lacking in Corynebacterium glutamicum. To better systematically understand PrxQ, we reported that PrxQ from model and important industrial organism C. glutamicum, encoded by the gene ncgl2403 annotated as a putative PrxQ, played important roles in adverse stress resistance. The lack of C. glutamicum prxQ gene resulted in enhanced cell sensitivity, increased ROS accumulation, and elevated protein carbonylation levels under adverse stress conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29429808/immune-parameters-to-p67c-antigen-adjuvanted-with-isa206vg-correlate-with-protection-against-east-coast-fever
#19
Anna Lacasta, Stephen Mwalimu, Elisabeth Kibwana, Rosemary Saya, Elias Awino, Thomas Njoroge, Jane Poole, Nicholas Ndiwa, Roger Pelle, Vishvanath Nene, Lucilla Steinaa
East Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29427748/the-non-thyroidal-illness-syndrome-is-associated-with-postoperative-surgical-site-infections-in-enterocutaneous-fistulae
#20
Huajian Ren, Jianan Ren, Gefei Wang, Zhiwu Hong, Guosheng Gu, Jun Chen, Xiuwen Wu, Qiongyuan Hu, Guanwei Li
BACKGROUND: Non-thyroidal illness syndrome (NTIS) is common in critically ill patients and associated with adverse outcomes. Many enterocutaneous fistula (ECF) patients still suffer NTIS prior to definitive surgery. This study was designed to explore the association between preoperative NTIS and postoperative outcomes in ECF patients. METHODS: A total of 264 ECF patients who underwent definitive surgery from April 2014 to November 2016 were studied. Thyroid hormones were tested for each patient before surgery, and the patients were divided into two groups (NTIS group and euthyroid group) according to the presence of NTIS...
February 7, 2018: International Journal of Surgery
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