keyword
MENU ▼
Read by QxMD icon Read
search

kurume university

keyword
https://www.readbyqxmd.com/read/27881473/clinicopathological-features-of-neoplasms-with-neuroendocrine-differentiation-occurring-in-the-liver
#1
Yoriko Nomura, Osamu Nakashima, Jun Akiba, Sachiko Ogasawara, Shogo Fukutomi, Rin Yamaguchi, Hironori Kusano, Masayoshi Kage, Koji Okuda, Hirohisa Yano
BACKGROUND/AIMS: We investigated the clinicopathological features of hepatic neuroendocrine tumours (NET) and neuroendocrine carcinoma (NEC), which remain largely unknown. MATERIAL AND METHODS: We examined 1235 tumours from 1048 patients who had undergone curative hepatectomy for liver neoplasms at Kurume University Hospital. Pathological diagnoses were based on the 2010 WHO Classification of Tumours of the Digestive System. We performed immunostaining for hepatocyte markers (eg, hepatocyte paraffin (HepPar)-1), neuroendocrine markers (eg, chromogranin A (CGA)) and the proliferation marker (Ki-67)...
November 23, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27811988/association-of-egfr-exon-19-deletion-and-egfr-tki-treatment-duration-with-frequency-of-t790m-mutation-in-egfr-mutant-lung-cancer-patients
#2
Norikazu Matsuo, Koichi Azuma, Kazuko Sakai, Satoshi Hattori, Akihiko Kawahara, Hidenobu Ishii, Takaaki Tokito, Takashi Kinoshita, Kazuhiko Yamada, Kazuto Nishio, Tomoaki Hoshino
The most common event responsible for resistance to first- and second-generation (1st and 2nd) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) is acquisition of T790M mutation. We examined whether T790M is related to clinicopathologic or prognostic factors in patients with relapse of EGFR mutant non-small cell lung cancer (NSCLC) after treatment with 1st or 2nd EGFR-TKIs. We retrospectively reviewed the T790M status and clinical characteristics of 73 patients with advanced or recurrent NSCLC who had been treated with EGFR-TKIs and undergone rebiopsy at Kurume University Hospital between March 2005 and December 2015...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27386941/vascular-inflammation-evaluated-by-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-is-associated-with-endothelial-dysfunction
#3
Akihiro Honda, Nobuhiro Tahara, Yoshikazu Nitta, Atsuko Tahara, Sachiyo Igata, Munehisa Bekki, Tomohisa Nakamura, Yoichi Sugiyama, Hayato Kaida, Seiji Kurata, Kiminori Fujimoto, Toshi Abe, Mika Enomoto, Hisashi Adachi, Jagat Narula, Sho-Ichi Yamagishi, Yoshihiro Fukumoto
OBJECTIVE: Endothelial dysfunction is an initial step in atherosclerotic cardiovascular disease. However, involvement of vascular inflammation in endothelial dysfunction is not fully investigated in humans because of the lack of diagnostic modality to noninvasively evaluate vascular inflammation. We assessed the relationship between endothelial function and vascular inflammation evaluated by [(18)F]-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging. APPROACH AND RESULTS: We examined endothelial function and vascular inflammation by flow-mediated dilation (FMD) of the brachial artery and [(18)F]-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging of carotid arteries, respectively, in 145 subjects (95 men and 50 women; mean age, 61...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27357981/characteristics-of-multidrug-resistant-corynebacterium-spp-isolated-from-blood-cultures-from-hospitalized-patients-in-japan
#4
Liang Qin, Yoshiro Sakai, Rong Bao, Hongmei Xie, Kenji Masunaga, Miho Miura, Kouji Hashimoto, Chiyoko Tanamachi, Bijie Hu, Hiroshi Watanabe
Corynebacterium spp. is genus of Gram-positive, rod-shaped bacteria, which are wildly distributed in nature. We reported the epidemiological investigation of Corynebacterium spp. isolated from bloodstream specimens in Kurume University Hospital, between June 2008 and July 2011. Twenty-two Corynebacterium spp. likely isolates were isolated from 22 hospitalized patients, of which 12 (54.5%) strains were identified as Corynebacterium striatum. Minimum inhibitory concentration tests were performed after biochemical and genotypic identifications...
June 30, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27258999/clinical-and-immunological-studies-of-49-cases-of-various-types-of-intercellular-iga-dermatosis-and-13-cases-of-classical-subcorneal-pustular-dermatosis-examined-at-kurume-university
#5
T Hashimoto, K Teye, N Ishii
OBJECTIVES: From our cohort of 5402 autoimmune bullous disease cases, we selected 49 cases with various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were sent from other institutes in Japan and other countries. METHODS: We studied clinically and immunologically the 49 IAD cases and the 13 classical SPD cases. RESULTS: There were 17 SPD-type IAD, 12 intraepidermal neutrophilic IgA dermatosis (IEN)-type IAD, two IgA-pemphigus vegetans, 4 IgA-pemphigus foliaceus, 6 IgA-pemphigus vulgaris and 8 unclassified IAD cases...
June 3, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27247994/clinical-and-immunological-studies-for-105-japanese-seropositive-patients-of-epidermolysis-bullosa-acquisita-examined-at-kurume-university
#6
Takashi Hashimoto, Zhexiong Jin, Norito Ishii
OBJECTIVES: Using our serological diagnostic criteria, we selected 105 Japanese patients with epidermolysis bullosa acquisita (EBA), an autoimmune bullous disease (AIBD) reacting with type VII collagen, from our cohort of 5063 AIBD patients. METHODS: We examined the patients clinically and immunologically. RESULTS: We found diversity of clinical manifestations in both cutaneous and oral mucosal lesions and a high rate of inflammatory-type EBA patients in Japan...
August 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27106498/summary-of-results-of-serological-tests-and-diagnoses-for-4774-cases-of-various-autoimmune-bullous-diseases-consulted-to-kurume-university
#7
T Hashimoto, D Tsuruta, H Koga, S Fukuda, B Ohyama, A Komai, T Karashima, C Ohata, K Teye, N Ishii
BACKGROUND: Although many new disease entities of autoimmune bullous disease (AIBD) are recently recognized, satisfactory immunological diagnostic method and comprehensive classification for various AIBDs have not been established. OBJECTIVE: In this study, we selected and examined 4774 patients with various AIBDs from our cohort of 5063 difficult AIBD patients, whose sera and information were sent for our diagnostic method from other institutes in either Japan or other countries for these 19 years...
April 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27041157/post-travel-consultations-in-a-regional-hub-city-hospital-japan
#8
Kenichiro Yaita, Yoshiro Sakai, Jun Iwahashi, Kenji Masunaga, Nobuyuki Hamada, Hiroshi Watanabe
OBJECTIVE: To clarify the characteristics of post-travel consultation services in Japan, particularly in the provinces, we analyzed our post-travel patients in the travel clinic of Kurume University Hospital located in Kurume City (a regional hub City in southwestern Japan). METHODS: Sixty post-travel patients visited our clinic between April 2008 and October 2014 and participated in this study: 55 were Japanese and five were foreign. We summarized and compared the characteristics of the patients after dividing the Japanese participants into long-term travelers (>14 days) and short-term travelers (≤14 days)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26984075/a-retrospective-analysis-of-drug-fever-diagnosed-during-infectious-disease-consultation
#9
Kenichiro Yaita, Yoshiro Sakai, Kenji Masunaga, Hiroshi Watanabe
OBJECTIVE: To clarify the current situation concerning drug fever (DF) in Japan, we retrospectively analyzed patients undergoing infectious disease consultation at our institution. METHODS: Between April 2014 and May 2015, we extracted the records of DF patients from among 388 patients who had obtained infectious disease consultations in Kurume University Hospital. We reviewed their medical charts and summarized the characteristics of DF. RESULTS: This study included the records of 16 patients...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26935570/patients-with-posttraumatic-stress-disorder-with-comorbid-major-depressive-disorder-require-a-higher-dose-of-psychotropic-drugs
#10
Hiromi Chiba, Misari Oe, Naohisa Uchimura
Major depressive disorder (MDD) has been associated with stressful life events and with posttraumatic stress disorder (PTSD). PTSD and MDD comorbidity was also reported to be associated with greater symptom severity and lower levels of functioning. However, the characteristics of pharmacotherapy for PTSD with MDD are not fully understood. To understand this relationship, we conducted a retrospective review using medical charts at the Department of Neuropsychiatry, Kurume University Hospital. Information from 55 patients with PTSD was analyzed...
2016: Kurume Medical Journal
https://www.readbyqxmd.com/read/26809536/-treatment-strategy-for-non-functional-pancreatic-neuroendocrine-tumors-p-nets-at-kurume-university-hospital
#11
Yusuke Kawashima, Hiroto Ishikawa, Toru Hisaka, Kouji Okuda, Yoshito Akagi
Pancreatic neuroendocrine tumors (P-NETs) are relatively rare. Approximately 50-90% of non-functioning P-NETs are malignant, and the only curative treatment is surgical resection. Liver and lymph node metastases often occur. In Japan, the mTOR inhibitor everolimus is now covered by the national health insurance for treatment of P-NETs, including advanced and unresectable tumors. We present a case of P-NETs with liver metastases seen at our hospital and discuss our treatment strategy for this disease. Patients with tumors≤1 cm receive follow-up observation...
January 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26794891/clinicopathologic-and-prognostic-implications-of-programmed-death-ligand-1-expression-in-thymoma
#12
Shintaro Yokoyama, Hiroaki Miyoshi, Tatsuya Nishi, Toshihiro Hashiguchi, Masahiro Mitsuoka, Shinzo Takamori, Yoshito Akagi, Tatsuyuki Kakuma, Koichi Ohshima
BACKGROUND: Programmed death ligand 1 (PD-L1) has been reported to be expressed in various malignancies and is considered to be a prognostic factor and an immunotherapeutic target. The aim of this study was to characterize PD-L1 expression in thymoma and determine statistical associations between this expression and clinical features. METHODS: We reviewed formalin-fixed, paraffin-embedded tissue specimens from 82 thymoma cases accumulated at Kurume University, the majority of which achieved surgical complete resection...
April 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26462957/risk-factors-for-and-circumstances-of-needlestick-and-sharps-injuries-of-doctors-in-operating-rooms-a-study-focusing-on-surgeries-using-general-anesthesia-at-kurume-university-hospital-japan
#13
Yuko Yonezawa, Koji Yahara, Miho Miura, Fumiyo Hieda, Ryoji Yamakawa, Kenji Masunaga, Yasunori Mishima, Hiroshi Watanabe
Healthcare workers are exposed to serious infectious diseases via needlestick and sharps injuries. The operating room is a particularly important environment in which the risk for needlestick injuries is increased for surgical doctors. According to national surveillance studies, the proportion of needlestick and sharps injuries in operating rooms has been increasing for unknown reasons. In this study, we examined risk factors for and circumstances of injuries in operating rooms by combining and analyzing incidence reports and electronic records of every surgery in Kurume University Hospital (Kurume, Japan)...
December 2015: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26026104/duration-of-first-line-treatment-with-molecular-targeted-therapy-is-a-prognostic-factor-in-metastatic-renal-cell-carcinoma
#14
Kosuke Ueda, Shigetaka Suekane, Kiyoaki Nishihara, Naoyuki Ogasawara, Hirofumi Kurose, Shuichiro Hayashi, Katsuaki Chikui, Shunsuke Suyama, Makoto Nakiri, Mitsunori Matsuo, Tsukasa Igawa
AIM: We investigated the prognostic factors associated with overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received molecular targeted-therapies. MATERIAL AND METHODS: A total of 66 patients underwent molecular targeted-therapies at the Kurume University between May 2008 and April 2014. Medical records were retrieved and analyzed retrospectively. RESULTS: The median OS was 25.9 [95% confidence interval (CI)=18...
June 2015: Anticancer Research
https://www.readbyqxmd.com/read/25810421/the-impact-of-body-mass-index-on-perioperative-outcomes-after-laparoscopic-colorectal-surgery
#15
Tetsushi Kinugasa, Takefumi Yoshida, Tomoaki Mizobe, Taro Isobe, Yosuke Oka, Yoshito Akagi
Laparoscopic colorectal surgery has gained increasing attention during the past 20 years. Surgeons today are more often confronted with obese patients. Therefore, it is timely to investigate the feasibility and safety of laparoscopic surgery for colorectal disease in obese patients. This study included 65 patients with colorectal disease who underwent laparoscopic surgery, between January 2009 and January 2014, at Kurume University Hospital. We divided the patients in this study into two groups based on their body mass index (BMI): <25 kg/m(2) (non-obese group) and ≥ 25 kg/m(2) (obese group)...
2015: Kurume Medical Journal
https://www.readbyqxmd.com/read/25790229/randomized-phase-ii-study-of-5-fluorouracil-hepatic-arterial-infusion-with-or-without-antineoplastons-as-an-adjuvant-therapy-after-hepatectomy-for-liver-metastases-from-colorectal-cancer
#16
RANDOMIZED CONTROLLED TRIAL
Yutaka Ogata, Keiko Matono, Hideaki Tsuda, Masataka Ushijima, Shinji Uchida, Yoshito Akagi, Kazuo Shirouzu
BACKGROUND: Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. Antineoplaston A10 and AS2-1 reportedly control neoplastic growth and do not significantly inhibit normal cell growth. Antineoplastons contain 3-phenylacetylamino-2, 6-piperidinedione (A10), phenylacetylglutamine plus phenylacetylisoglutamine (A10-I), and phenylacetylglutamine plus phenylacetate (AS2-1). This open label, non- blinded randomized phase II study compared the efficacy of hepatic arterial infusion (HAI) with 5-fluorouracil,with or without antineoplastons as a postoperative therapy for colorectal metastasis to the liver...
2015: PloS One
https://www.readbyqxmd.com/read/25075111/benefit-of-lateral-lymph-node-dissection-for-rectal-cancer-long-term-analysis-of-944-cases-undergoing-surgery-at-a-single-center-1975-2004
#17
Tetsushi Kinugasa, Yoshito Akagi, Kazuo Shirouzu
BACKGROUND: Pelvic sidewall dissection (PSD) has the potential to decrease local recurrence so that PSD may be an effective strategy for lower rectal cancer. Therefore, it is important to investigate the validity of PSD for its potential clinical use in lower rectal cancer therapy and prognosis. PATIENTS AND METHODS: The present study included all 994 patients with rectal cancer who underwent curative surgery from January 1975 until December 2004 at the Kurume University Hospital in Fukuoka...
August 2014: Anticancer Research
https://www.readbyqxmd.com/read/25075101/minichromosome-maintenance-protein-7-is-a-risk-factor-for-recurrence-in-patients-with-dukes-c-colorectal-cancer
#18
Yoshiaki Ishibashi, Tetsushi Kinugasa, Yoshito Akagi, Takafumi Ohchi, Yukito Gotanda, Natsuki Tanaka, Shinya Fujino, Kotaro Yuge, Shiro Kibe, Naohiro Yoshida, Tomoaki Mizobe, Yosuke Oka, Takefumi Yoshida, Kazuo Shirouzu
BACKGROUND: It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes. PATIENTS AND METHODS: The study included 145 patients with colorectal cancer who underwent curative surgery, from January 2002 until December 2004, at the Kurume University Hospital in Fukuoka, Japan...
August 2014: Anticancer Research
https://www.readbyqxmd.com/read/24827996/cytological-nuclear-atypia-classification-can-predict-prognosis-in-patients-with-endometrial-cancer
#19
T Yamaguchi, A Kawahara, S Hattori, T Taira, H Abe, S Sanada, J Akiba, S Nishio, K Ushijima, T Kamura, M Kage
OBJECTIVE: Endometrial cancer is one of the leading causes of malignancy in females. Nuclear findings are important for patients with cancer, and can provide valuable information to treating oncologists. We investigated whether nuclear findings were a useful prognostic factor in patients with endometrial cancer. METHOD: We investigated 71 cases of endometrial carcinoma with paired histology and cytology at Kurume University Hospital. We classified endometrial endometrioid adenocarcinoma (EEC) G1 and G2 as type I carcinomas, and uterine papillary serous carcinoma (UPSC), clear cell carcinoma (CC) and EEC G3 as type II carcinomas...
June 2015: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/24692736/multimodal-approach-for-cervical-esophageal-carcinoma-role-of-neoadjuvant-chemotherapy
#20
Gen Suzuki, Hideya Yamazaki, Etsuyo Ogo, Toshi Abe, Hidehiro Eto, Koichiro Muraki, Chikayuki Hattori, Hirohito Umeno, Tadashi Nakashima, Toshiaki Tanaka, Satoaki Nakamura, Ken Yoshida
AIM: To examine the outcome of patients with cervical esophageal cancer treated by a multimodal protocol. PATIENTS AND METHODS: We retrospectively analyzed the outcome and prognostic factors for 20 patients with cervical esophageal cancer who received multimodal treatment at the Kurume University Hospital between 2003 and 2009. One case of stage I, seven of stage II and 12 of stage III disease (2 T1, 3 T2, 4 T3, 11 T4 and 14 N1) were included. Radiotherapy was administered at a median dose of 60 Gy (range=30-70 Gy)...
April 2014: Anticancer Research
keyword
keyword
37689
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"