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https://www.readbyqxmd.com/read/28340094/nlrp2-is-a-suppressor-of-nf-%C3%A6-b-signaling-and-hla-c-expression-in-human-trophoblasts
#1
Tamara Tilburgs, Torsten B Meissner, Leonardo M R Ferreira, Arend Mulder, Kiran Musunuru, Junqiang Ye, Jack L Strominger
During human pregnancy, fetal extravillous trophoblasts (EVT) play a key role in the regulation of maternal T cell and NK cell responses. EVT display a unique combination of Human Leukocyte Antigens (HLA); EVT do not express HLA-A and HLA-B, but do express HLA-C, HLA-E and HLA-G. The mechanisms establishing this unique HLA expression pattern have not been fully elucidated. The MHC class I and class II transcriptional activators NLRC5 and CIITA are expressed neither by EVT nor by the EVT model cell line JEG3, which has an MHC expression pattern identical to that of EVT...
March 7, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28333608/morbidity-in-pregnant-women-associated-with-unverified-penicillin-allergies-antibiotic-use-and-group-b-streptococcus-infections
#2
Shilpa H Desai, Michael S Kaplan, Qiaoling Chen, Eric M Macy
CONTEXT: The morbidity potentially associated with unverified penicillin allergy in pregnant women, with and without group B streptococcus (GBS) infections, is unknown. Penicillin allergy testing is safe during pregnancy but is done infrequently. OBJECTIVE: To determine morbidity associated with antibiotic use in a large cohort of pregnant women, with and without an unverified history of penicillin allergy, and with and without GBS. DESIGN: Retrospective...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28330857/estimated-disability-adjusted-life-years-averted-by-free-of-charge-provision-of-the-levonorgestrel-releasing-intrauterine-system-over-a-9-year-period-in-brazil
#3
Jessica M Ferreira, Ilza Monteiro, Arlete Fernandes, Maria V Bahamondes, Ana Pitoli, Luis Bahamondes
BACKGROUND: The objective was to analyse the contribution of the provision at no cost to users of the 20 µg/day levonorgestrel-releasing intrauterine system (LNG-IUS) towards disability-adjusted life years (DALY) averted over a 9-year period. METHODS: We analysed data from 15 030 new users of the LNG-IUS who had the device inserted at 26 Brazilian teaching hospitals between January 2007 and December 2015. The devices came from the International Contraceptive Access Foundation (ICA), a not-for-profit foundation that donates the devices to developing countries for use by low-income women who desire long-term contraception and who freely choose to use this device...
March 22, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28330856/-my-friend-who-bought-it-for-me-she-has-had-an-abortion-before-the-influence-of-ghanaian-women-s-social-networks-in-determining-the-pathway-to-induced-abortion
#4
Sarah D Rominski, Jody R Lori, Emmanuel Sk Morhe
BACKGROUND: Even given the liberal abortion law in Ghana, abortion complications are a large contributor to maternal morbidity and mortality. This study sought to understand why young women seeking an abortion in a legally enabling environment chose to do this outside the formal healthcare system. METHODS: Women being treated for complications arising from a self-induced abortion as well as for elective abortions at three hospitals in Ghana were interviewed. Community-based focus groups were held with women as well as men, separately...
March 22, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28301806/the-effects-of-women-s-education-on-maternal-health-evidence-from-peru
#5
Abigail Weitzman
This article examines the causal effect of women's education on maternal health in Peru, a country where maternal mortality has declined by more than 70% in the last two and a half decades. To isolate the effects of education, the author employs an instrumented regression discontinuity that takes advantage of an exogenous source of variation-an amendment to compulsory schooling laws in 1993. The results indicate that extending women's years of schooling reduced the probability of several maternal health complications at last pregnancy/birth, sometimes by as much as 29%...
March 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28292296/sexual-and-reproductive-health-experience-knowledge-and-problems-among-university-students-in-ambo-central-ethiopia
#6
Abenezer Yared, Zekariyas Sahile, Mulugeta Mekuria
BACKGROUND: Youths in universities are at high risk of STIs and SRH problems in Ethiopia. However, students did not perceive themselves at risk of STI/HIV infection though reports showed they were sexually active, had multiple sexual partners and reported symptoms of STIs. Having recognized the threat posed by SRH problems, this study aimed to assess the SRH experiences, knowledge, and problems among university students at Ambo University in Ethiopia. METHODS: A cross-sectional study was conducted in Ambo University main campus from January to February 2015 using mixed approach of quantitative (survey) and qualitative (in-depth interview) methods...
March 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28285310/incidence-and-causes-of-intentional-fetal-or-neonatal-demise-in-twin-twin-transfusion-syndrome
#7
Marjolijn S Spruijt, Ellen Tameeris, De-Peng Zhao, Johanna M Middeldorp, Monique C Haak, Dick Oepkes, Enrico Lopriore
INTRODUCTION: The aim of this study is to evaluate the incidence and causes of intentional fetal and neonatal demise in twin-twin transfusion syndrome (TTTS). MATERIAL AND METHODS: All TTTS pregnancies managed at our centre between 2000 and 2014 were included. We evaluated incidence and causes of intentional fetal/neonatal demise, defined as termination of pregnancy, selective fetal reduction, or withdrawal of neonatal intensive care. RESULTS: Intentional fetal/neonatal demise occurred in 9...
March 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28283499/metabolite-identification-reaction-phenotyping-and-retrospective-drug-drug-interaction-predictions-of-17-deacetylnorgestimate-the-active-component-of-the-oral-contraceptive-norgestimate
#8
Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar, Murali Subramanian
Ortho-Tri-Cyclen® (OTC), a two drug cocktail comprising of ethinylestradiol (EE) and norgestimate (13-ethyl-17-acetoxy-18, 19-dinor-17α-pregn-4-en-20yn-3 oxime), is commonly prescribed to avert unwanted pregnancies in women of reproductive age. In vivo, norgestimate undergoes extensive and rapid deacetylation to produce 17-deacetylnorgestimate (NGMN), an active circulating metabolite that likely contributes significantly to norgestimate efficacy. Despite being of primary significance, the metabolism and reaction phenotyping of NGMN have not been previously reported...
March 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28245457/steroids-and-autoimmunity
#9
Amelia Chiara Trombetta, Marianna Meroni, Maurizio Cutolo
From the middle of the 19th century, it is known that endocrine and immune systems interact bi-directionally in different processes that ensure organism homeostasis. Endocrine and nervous systems have a pivotal role in the balancing of pro- and anti-inflammatory functions of immune system, and constitute a complex circadian neuroendocrine network. Autoimmune diseases have in fact a complex pathogenic origin in which the importance of endocrine system was demonstrated. In this chapter, we will mention the structure and function of steroidal hormones involved in the neuroendocrine immune network and we will address the ways in which endocrine and immune systems influence each other, in a bi-directional fashion...
2017: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/28238998/factors-associated-with-contraceptive-use-among-women-of-reproductive-age-in-rural-districts-of-burkina-faso
#10
Joseph K Wulifan, Jacob Mazalale, Albrecht Jahn, Hervé Hien, Patrick Christian Ilboudo, Nicolas Meda, Paul Jacob Robyn, Saidou Hamadou, Ousmane Haidara, Manuela De Allegri
Given the current low contraceptive use and corresponding high levels of unwanted pregnancies leading to induced abortions and poor maternal health outcomes among rural populations, a detailed understanding of the factors that limit contraceptive use is essential. Our study investigated household and health facility factors that influence contraceptive use decisions among rural women in rural Burkina Faso. We collected data on fertile non-pregnant women in 24 rural districts in 2014. Of 8,657 women, 1,098 used a modern contraceptive...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28193721/women-s-limited-choice-and-availability-of-modern-contraception-at-retail-outlets-and-public-sector-facilities-in-luanda-angola-2012-2015
#11
Benjamin Nieto-Andrade, Eva Fidel, Rebecca Simmons, Dana Sievers, Anya Fedorova, Suzanne Bell, Karen Weidert, Ndola Prata
In Angola, many women want to use family planning but lack access to affordable and preferred methods. This article assesses the link between women's choice and availability of contraceptive methods in Luanda, Angola, drawing on data from 3 surveys: a 2012 survey among women ages 15-49 and 2 retail surveys conducted in 2014 and 2015 among outlets and facilities offering contraceptive methods. Descriptive statistics for women's contraceptive knowledge, use, and preferred methods were stratified by age group...
February 13, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28188146/abortion-and-fertility-control-in-pakistan-the-role-of-misoprostol
#12
Harneet Chahal, Zubia Mumtaz
OBJECTIVE: To examine how availability of misoprostol has impacted women's abortion-seeking behaviour in Pakistan. DESIGN: Focused ethnography. SETTING: A facility providing reproductive health services, including induced abortions in Chakwal, a small town in Northern Punjab, Pakistan. POPULATION: Women who came to the clinic seeking an abortion or who had had one in the last 6 months (n=23) and all healthcare providers working in the facility (n=14)...
February 10, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28178128/the-association-between-pregnancy-intendedness-and-experiencing-symptoms-of-postpartum-depression-among-new-mothers-in-the-united-states-2009-to-2011-a-secondary-analysis-of-prams-data
#13
Christina Gauthreaux, Jenesis Negron, Daniel Castellanos, Melissa Ward-Peterson, Grettel Castro, Pura Rodríguez de la Vega, Juan Manuel Acuña
Postpartum depression (PPD) is a form of major depressive disorder affecting approximately 13% of women worldwide. Unintended pregnancies, reaching close to 50% of the pregnancies in the United States, have become a major health concern. While many physiologic and psychosocial causes have been analyzed, few studies have examined the relationship between unintended pregnancy and symptoms of PPD.A cross-sectional study was conducted using surveillance data from the Centers for Disease Control and Prevention's Pregnancy Risk Assessment Monitoring System (PRAMS) from 2009 to 2011...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28155757/-introduction-despite-health-education-efforts-young-people-are-still-faced-with-major-health-problems-the-objective-of-this-study-was-to-assess-the-knowledge-and-attitude-regarding-hiv-prevention-and-unwanted-pregnancy-among-young-people-in-bobo-dioulasso
#14
Clétus Come Yélian Adohinzin, Nicolas Meda, Georges Anicet Ouédraogo, Adrien Marie Gaston Belem, Issiaka Sombié, Abdramane Berthé, Ngianga Bakwin Kandala, Georgette Damienne Avimadjenon, Laurence Fond-Harmant
A significant proportion of young people still has incomplete knowledge about HIV/AIDS and contraception. Actions designed to reinforce the knowledge of young people are of paramount importance. The capacities of parents and healthcare providers also need to be reinforced to improve the quality of relationship with young people.</ce:para>.
October 19, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28104040/sexual-health-knowledge-and-behaviour-of-young-sudanese-queenslanders-a-cross-sectional-study
#15
Judith Dean, Marion Mitchell, Donald Stewart, Joseph Debattista
Background: Forced migration is associated with sexual vulnerability. However, little is known about the sexual health literacy and needs of refugee-background youth post resettlement. Methods: Conducted in partnership with the Queensland Sudanese community, this study used a cross-sectional survey to explore the sexual health knowledge, attitudes and behaviours of a convenience sample of 16- to 24-year-old Sudanese-background youth in Australia (n=229). Results: Sexually transmissible infection (STI) and HIV knowledge scores were generally low, although they were found to significantly improve the longer participants had lived in Australia (P<0...
January 20, 2017: Sexual Health
https://www.readbyqxmd.com/read/28103918/the-effects-of-asking-a-fertility-intention-question-in-primary-care-settings-a-systematic-review-protocol
#16
Paul A Henning, Carolyne K Burgess, Heidi E Jones, Wendy V Norman
BACKGROUND: Planning for pregnancy has been associated with reduced unwanted pregnancies and improved pregnancy outcomes. Despite the benefits of planned pregnancy, there are no guideline recommendations on routine counseling regarding pregnancy intention in primary care settings. The objective of the systematic review is to determine the effectiveness of incorporating questions of pregnancy intention into primary care. METHODS: A systematic search of the literature will be conducted for any studies comparing questions of pregnancy intention in primary care settings with no intervention or a control intervention...
January 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28103896/sexual-and-reproductive-health-services-utilization-by-female-sex-workers-is-context-specific-results-from-a-cross-sectional-survey-in-india-kenya-mozambique-and-south-africa
#17
Yves Lafort, Ross Greener, Anuradha Roy, Letitia Greener, Wilkister Ombidi, Faustino Lessitala, Jolene Skordis-Worrall, Mags Beksinska, Peter Gichangi, Sushena Reza-Paul, Jenni A Smit, Matthew Chersich, Wim Delva
BACKGROUND: Female sex workers (FSWs) are extremely vulnerable to adverse sexual and reproductive health (SRH) outcomes. To mitigate these risks, they require access to services covering not only HIV prevention but also contraception, cervical cancer screening and sexual violence. To develop context-specific intervention packages to improve uptake, we identified gaps in service utilization in four different cities. METHODS: A cross-sectional survey was conducted, as part of the baseline assessment of an implementation research project...
January 19, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28097182/the-role-of-mass-media-in-iranian-youth-s-premarital-sexual-relationships-a-qualitative-study
#18
Fariba Taleghani, Effat Al Sadat Merghati Khoie, Mahnaz Noroozi, Mahgol Tavakoli, Ali Gholami
BACKGROUND: Youth's sexual behaviors have various consequences such as unwanted pregnancy, acquired immunodeficiency syndrome and sexually transmitted infections. Little information is available about the impact of mass media in the development of premarital sexual relationships. This study aimed to explore the role of mass media on premarital sexual relationships among Iranian youth. METHODS: This qualitative study was conducted with 26 single boys and girls aged 18-24 years who were living in Isfahan, Iran and have already been started their sexual relationships...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28024683/how-can-a-state-control-swallowing-the-home-use-of-abortion-pills-in-ireland
#19
Sally Sheldon
Evidence suggests that there is widespread home use of abortion pills in Ireland and that ending a pregnancy in this way is potentially safer than the alternatives available to many women. This paper argues that there is a strong case for women with unwanted pregnancies to be offered truthful and objective information regarding the use of abortion pills by trusted local professionals and, further, that this is possible within existing law. A move in this direction would not, however, negate the need for legal reform to address the fundamental moral incoherence of a law that treats women who terminate pregnancies within Ireland as criminals but those who travel to access services overseas as victims in need of support...
November 2016: Reproductive Health Matters
https://www.readbyqxmd.com/read/28013257/use-of-proton-pump-inhibitors-and-the-risk-of-listeriosis-a-nationwide-registry-based-case-control-study
#20
Anne Kvistholm Jensen, Jacob Simonsen, Steen Ethelberg
BACKGROUND: Recent studies suggest that proton pump inhibitors (PPIs) may increase the risk for listeriosis. We aimed to investigate a potential association in cases of non-pregnancy associated listeriosis, using registry data. METHODS: We conducted a population-based case-control study using Danish health registries. Case-patients (n=721) were defined as patients ≥45 years notified with listeriosis, July 1994 to December 2012. We selected 34,800 control-subjects by risk-set sampling...
December 24, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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