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https://www.readbyqxmd.com/read/28748704/understanding-the-experiences-of-married-southern-african-women-in-protecting-themselves-from-hiv-aids-a-systematic-review-and-meta-synthesis
#1
Tabeth Timba-Emmanuel, Thilo Kroll, Mary J Renfrew, Steve MacGillivray
BACKGROUND: Whilst marriage has been repeatedly identified in the literature as an HIV risk factor amongst Southern African women, not much is known about women's perception of their role, experiences and strategies used to address HIV risks in the context of a marriage. AIMS: The aim of the study was to synthesise perceptions, experiences and strategies of married Southern African women in the prevention of HIV. METHODS: A systematic review of qualitative studies was conducted...
July 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28748197/incidence-long-term-outcomes-and-healthcare-utilization-of-patients-with-human-immunodeficiency-virus-acquired-immune-deficiency-syndrome-and-disseminated-mycobacterium-avium-complex-from-1992-2015
#2
Lauren F Collins, Meredith E Clement, Jason E Stout
BACKGROUND: Despite the advent of combination antiretroviral therapy (cART), patients with human immunodeficiency virus (HIV) continue to develop late-stage complications including acquired immune deficiency syndrome (AIDS), disseminated Mycobacterium avium complex (DMAC), and death. METHODS: We performed an observational retrospective cohort study of HIV-infected adults who developed DMAC in the Duke University Health System from 1992 to 2015 to determine the incidence, long-term outcomes, and healthcare utilization of this population at high risk for poor outcomes...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28748017/-factors-associated-with-immunovirologic-dissociation-in-hiv-1-infected-patients-under-highly-active-antiretroviral-therapy-in-the-ambulatory-treatment-center-atc-in-dakar
#3
Daye Kà, Noël Magloire Manga, Ndéye Fatou Ngom-Guéye, Diop Ndiaga, Moustapha Diop, Viviane Marie Pierre Cisse-Diallo, Khardiata Diallo-Mbaye, Ndèye Aissatou Lakhe, Louise Fortès-Déguenonvo, Cheikh Tidiane Ndour, Sylvie Audrey Diop-Nyafouna, Moussa Seydi
INTRODUCTION: The objective of this work is to evaluate the different factors associated with immunovirologic dissociation despite highly active and effective antiretroviral treatment. METHODS: We conducted a retrospective, cohort, descriptive and analytical study of the medical records of HIV-1 infected patients having received at least 12 months of antiretroviral therapy, followed in the ATC cohort from 2001 to 2011 and with undetectable viral load in the last 6 months...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747447/long-term-aids-related-pcnsl-outcomes-with-hd-mtx-and-combined-antiretroviral-therapy
#4
Antoine Moulignier, Cédric Lamirel, Hervé Picard, Marie-Gisèle Lebrette, Corinne Amiel, Mohammed Hamidi, Marc Polivka, Jacqueline Mikol, Isabelle Cochereau, Gilles Pialoux
OBJECTIVE: To assess the characteristics and outcomes of patients with AIDS-related primary CNS lymphoma (AR-PCNSL) in the combined antiretroviral therapy (cART) era systematically treated with high-dose methotrexate (HD-MTX). METHODS: We retrospectively analyzed (intention-to-treat analysis) 51 consecutive patients with AR-PCNSL (median age 39 years) who were diagnosed from 1996 to 2014 and treated with a median of 6 (range 1-15) infusions of HD-MTX (3 g/m(2)) combined with cART...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28747207/lessons-learnt-from-the-magnet-malawian-german-hospital-partnership-the-german-perspective-on-contributions-to-patient-care-and-capacity-development
#5
Florian Neuhann, Sandra Barteit
BACKGROUND: Malawi is a low-income country with one of the highest HIV prevalence rates worldwide (Kendig et al., Trop Med Health 41:163-170, 2013). The health system depends largely on external funding. Official German development aid has supported health care in Malawi for many years (German Embassy Lilongwe, The German Development Cooperation in Malawi), including placing medical doctors in various departments of the Kamuzu Central Hospital (KCH) in Lilongwe. In 2008, a hospital partnership called MAGNET (Malawi German Networking for Capacity Building in Treatment, Training and Research at KCH) evolved as part of the German ESTHER network...
July 26, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28746656/mortality-due-to-noncommunicable-diseases-in-brazil-1990-to-2015-according-to-estimates-from-the-global-burden-of-disease-study
#6
Deborah Carvalho Malta, Elisabeth França, Daisy Maria Xavier Abreu, Rosângela Durso Perillo, Maíra Coube Salmen, Renato Azeredo Teixeira, Valeria Passos, Maria de Fátima Marinho Souza, Meghan Mooney, Mohsen Naghavi
CONTEXT AND OBJECTIVE: Noncommunicable diseases (NCDs) are the leading health problem globally and generate high numbers of premature deaths and loss of quality of life. The aim here was to describe the major groups of causes of death due to NCDs and the ranking of the leading causes of premature death between 1990 and 2015, according to the Global Burden of Disease (GBD) 2015 study estimates for Brazil. DESIGN AND SETTING: Cross-sectional study covering Brazil and its 27 federal states...
May 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28746573/quality-of-life-socioeconomic-and-clinical-factors-and-physical-exercise-in-persons-living-with-hiv-aids
#7
Rafaela Catherine da Silva Cunha de Medeiros, Jason Azevedo de Medeiros, Tatiane Andreza Lima da Silva, Ricardo Dias de Andrade, Danielle Coutinho de Medeiros, Juliany de Souza Araújo, Antônio Manuel Gouveia de Oliveira, Marcos Aurélio de Albuquerque Costa, Paulo Moreira Silva Dantas
OBJECTIVE: To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS: This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise...
July 20, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28746533/frequency-of-indeterminate-results-from-an-interferon-gamma-release-assay-among-hiv-infected-individuals
#8
Sandra Maria do Valle Leone de Oliveira, Anete Trajman, Anamaria Mello Miranda Paniago, Ana Rita Coimbra Motta-Castro, Antonio Ruffino-Netto, Ethel Leonor Noia Maciel, Julio Croda, Maria da Gloria Bonecini-Almeida
Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28746165/effect-of-immediate-initiation-of-antiretroviral-treatment-in-hiv-positive-individuals-aged-50-years-or-older
#9
Sara Lodi, Dominique Costagliola, Caroline Sabin, Julia Del Amo, Roger Logan, Sophie Abgrall, Peter Reiss, Ard van Sighem, Sophie Jose, Jose-Ramon Blanco, Victoria Hernando, Heiner C Bucher, Helen Kovari, Ferran Segura, Juan Ambrosioni, Charalambos A Gogos, Nikos Pantazis, Francois Dabis, Marie-Anne Vandenhende, Laurence Meyer, Rémonie Seng, John Gill, Hartmut Krentz, Andrew Phillips, Kholoud Porter, Beatriz Grinsztejn, Antonio G Pacheco, Roberto Muga, Janet Tate, Amy Justice, Miguel A Hernán
BACKGROUND: Clinical guidelines recommend immediate initiation of combined antiretroviral therapy (ART) for all HIV-positive individuals. However, those guidelines are based on trials of relatively young participants. METHODS: We included HIV-positive ART-naïve, AIDS-free individuals aged 50-70 years after 2004 in the HIV-CAUSAL Collaboration. We used the parametric g-formula to estimate the 5-year risk of all-cause and non-AIDS mortality under: i) immediate initiation at baseline, and initiation at CD4 count ii) <500 cells/mm, and iii) <350 cells/mm...
July 21, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28745592/the-international-aids-society-lancet-commission-on-the-future-of-the-hiv-response-and-global-health
#10
Chris Beyrer, Pamela Das, Richard Horton, Owen Ryan, Linda-Gail Bekker
No abstract text is available yet for this article.
July 22, 2017: Lancet
https://www.readbyqxmd.com/read/28745587/the-global-hiv-aids-epidemic-progress-and-challenges
#11
EDITORIAL
The Lancet
No abstract text is available yet for this article.
July 22, 2017: Lancet
https://www.readbyqxmd.com/read/28745207/hiv-drug-resistance-testing-in-a-resource-limited-setting-with-high-viral-diversity-the-first-twenty-eight-months-experience
#12
Elodie Teclaire Ngo-Malabo, Paul Alain Ngoupo, Serge Alain Sadeuh-Mba, Emmanuel Akongnwi, Robert Banaï, Laure Ngono, Richard Njouom, Charles Felix Bilong-Bilong, Anfumbom Kfutwah
BACKGROUND: First line antiretroviral therapy in a resource-limited setting consists of nucleotide and non-nucleotide reverse transcriptase inhibitors. Protease inhibitors are the hub of second line therapy. The decision to change antiretroviral therapy for a patient is frequently presumptive because of the lack of genotypic resistance tests in routine follow-up. We describe here the resistance profiles observed in patients with varying terms of antiretroviral therapy in Cameroon after implementation of HIV genotypic resistance testing in routine practice...
July 25, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28744883/doubly-robust-inference-for-targeted-minimum-loss-based-estimation-in-randomized-trials-with-missing-outcome-data
#13
Iván Díaz, Mark J van der Laan
Missing outcome data is a crucial threat to the validity of treatment effect estimates from randomized trials. The outcome distributions of participants with missing and observed data are often different, which increases bias. Causal inference methods may aid in reducing the bias and improving efficiency by incorporating baseline variables into the analysis. In particular, doubly robust estimators incorporate 2 nuisance parameters: the outcome regression and the missingness mechanism (ie, the probability of missingness conditional on treatment assignment and baseline variables), to adjust for differences in the observed and unobserved groups that can be explained by observed covariates...
July 25, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28743661/chronic-pain-patient-physician-engagement-and-family-communication-associated-with-drug-using-hiv-patients-discussing-advanced-care-planning-with-their-physicians
#14
Eric D Hansen, Mary M Mitchell, Tom Smith, Nancy Hutton, Jeanne Keruly, Amy R Knowlton
CONTEXT: In the era of effective antiretroviral therapy, persons living with HIV/AIDS (PLWHA) are living longer, transforming HIV into a serious chronic illness, warranting patient-provider discussion about advanced care planning (ACP). Evidence is needed to inform physicians on how to approach ACP for these patients. Chronic pain is common in PLWHA, particularly in those who have substance use disorders; although it is known this population is at risk for poorer patient-physician engagement, the effects on ACP are unknown...
July 22, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28743254/association-between-serotonin-transporter-gene-polymorphisms-and-increased-suicidal-risk-among-hiv-positive-patients-in-uganda
#15
Allan Kalungi, Soraya Seedat, Sian M J Hemmings, Lize van der Merwe, Moses L Joloba, Ann Nanteza, Noeline Nakassujja, Harriet Birabwa, Jennifer Serwanga, Pontiano Kaleebu, Eugene Kinyanda
BACKGROUND: Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA...
July 25, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28742829/community-burden-of-undiagnosed-hiv-infection-among-adolescents-in-zimbabwe-following-primary-healthcare-based-provider-initiated-hiv-testing-and-counselling-a-cross-sectional-survey
#16
Victoria Simms, Ethel Dauya, Subathira Dakshina, Tsitsi Bandason, Grace McHugh, Shungu Munyati, Prosper Chonzi, Katharina Kranzer, Getrude Ncube, Collen Masimirembwa, Roslyn Thelingwani, Tsitsi Apollo, Richard Hayes, Helen A Weiss, Rashida A Ferrand
BACKGROUND: Children living with HIV who are not diagnosed in infancy often remain undiagnosed until they present with advanced disease. Provider-initiated testing and counselling (PITC) in health facilities is recommended for high-HIV-prevalence settings, but it is unclear whether this approach is sufficient to achieve universal coverage of HIV testing. We aimed to investigate the change in community burden of undiagnosed HIV infection among older children and adolescents following implementation of PITC in Harare, Zimbabwe...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742529/risk-factors-for-early-mortality-on-antiretroviral-therapy-in-advanced-hiv-infected-adults
#17
Gregory P Bisson, Ritesh Ramchandani, Sachiko Miyahara, Rosie Mngqibisa, Mitch Matoga, McNeil Ngongondo, Wadzanai Samaneka, Lucy Koech, Kogieleum Naidoo, Mohammed Rassool, Fredrick Kirui, Peter Banda, Vidya Mave, Dileep Kadam, Paul Leger, German Henostroza, Yukari C Manabe, Jing Bao, Johnstone Kumwenda, Amita Gupta, Mina C Hosseinipour
BACKGROUND: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. METHODS: We used data from a multi-site randomized trial comparing empiric versus preventive TB therapy in HIV-infected adults initiating ART with CD4 counts <50 cells/mm to evaluate risk factors for death within 48 weeks after ART initiation...
July 24, 2017: AIDS
https://www.readbyqxmd.com/read/28742447/a-crisis-emerges-lesbian-health-between-breast-cancer-and-hiv-aids
#18
Mairead Sullivan
In this essay, I argue that lesbians have come to be a population of concern for state-based health organizations as a result of lesbian health activism that drew connections between breast cancer and HIV/AIDS. In order to develop this analysis, I tell the story of the rise of lesbian breast cancer activism in concert with HIV/AIDS in San Francisco in the early 1990s. The state recognition of lesbian health needs, and with it the solidification of lesbian as a biopolitical category, was catalyzed by associations with the AIDS crisis and HIV activism, but also required an articulated difference, or lesbian specificity, which breast cancer provided...
July 25, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28742103/impact-of-teachers-training-on-hiv-aids-education-program-among-secondary-school-students-in-bangladesh-a-cross-sectional-survey
#19
Haribondhu Sarma, Mohammad Ashraful Islam, Jahidur Rahman Khan, Kamal Ibne Amin Chowdhury, Rukhsana Gazi
BACKGROUND: In 2007, the Government of Bangladesh incorporated a chapter on HIV/AIDS into the national curriculum for an HIV-prevention program for school students. For the efficient dissemination of knowledge, an intervention was designed to train the teachers and equip them to educate on the topic of HIV/AIDS. The present study intended to understand the impact of this intervention by assessing the knowledge, attitudes and behaviours related to HIV/AIDS, among the targeted students...
2017: PloS One
https://www.readbyqxmd.com/read/28741983/-taking-care-in-the-age-of-aids-older-rural-south-africans-strategies-for-surviving-the-hiv-epidemic
#20
Nicole Angotti, Sanyu A Mojola, Enid Schatz, Jill R Williams, F Xavier Gómez-Olivé
Older adults have been largely overlooked in community studies of HIV in highly endemic African countries. In our rural study site in Mpumalanga Province, South Africa, HIV prevalence among those aged 50 and older is 16.5%, suggesting that older adults are at risk of both acquiring and transmitting HIV. This paper utilises community-based focus-group interviews with older rural South African men and women to better understand the normative environment in which they come to understand and make decisions about their health as they age in an HIV endemic setting...
July 25, 2017: Culture, Health & Sexuality
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