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Pregnancy, maternal, fetal

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https://www.readbyqxmd.com/read/28820906/exposure-to-fine-particulate-matter-in-the-air-alters-placental-structure-and-the-renin-angiotensin-system
#1
Sônia de Fátima Soto, Juliana Oliveira de Melo, Guilherme D'Aprile Marchesi, Karen Lucasechi Lopes, Mariana Matera Veras, Ivone Braga de Oliveira, Regiane Machado de Souza, Isac de Castro, Luzia Naôko Shinohara Furukawa, Paulo Hilário Nascimento Saldiva, Joel C Heimann
METHODS: Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1 and RAS were evaluated by indirect ELISA and quantitative real-time PCR. RESULTS: Exposure to P decreased the placental mass, size, and surface area as well as the TGFβ1, VEGF-A and Flk-1 content...
2017: PloS One
https://www.readbyqxmd.com/read/28820871/genetic-predisposition-to-fetal-alcohol-syndrome-association-with-congenital-disorders-of-n-glycosylation
#2
María E de la Morena-Barrio, María J Ballesta-Martínez, Raquel López-Gálvez, Ana I Antón, Vanessa López-González, Laia Martínez-Ribot, José Padilla, Antonia Miñano, Oscar García-Algar, Miguel Del Campo, Javier Corral, Encarna Guillén-Navarro, Vicente Vicente
BACKGROUND: Fetal alcohol syndrome (FAS) is caused by maternal alcohol consumption during pregnancy, although additional factors must be involved, as development and severity are not directly related to alcohol intake. The abnormal glycosylation caused by alcohol might play a role in FAS according to the clinical similarities shared with congenital disorders of glycosylation (CDG). Thus, mutations underlying CDG, affecting genes involved in glycosylation, could also be involved in FAS...
August 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28820654/locus-specific-dna-methylation-in-the-placenta-is-associated-with-levels-of-pro-inflammatory-proteins-in-cord-blood-and-they-are-both-independently-affected-by-maternal-smoking-during-pregnancy
#3
Sanne D van Otterdijk, Alexandra M Binder, Karin B Michels
We investigated the impact of maternal smoking during pregnancy on placental DNA methylation and how this may mediate the association between maternal smoking and pro-inflammatory proteins in cord blood. The study population consisted of 27 individuals exposed to maternal smoking throughout pregnancy, 32 individuals exposed during a proportion of the pregnancy, and 61 unexposed individuals. Methylation of 11 regions within 6 genes in placenta tissue was assessed by pyrosequencing. Levels of 7 pro-inflammatory proteins in cord blood were assessed by electrochemiluminescence...
August 18, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28819941/maternal-and-neonatal-outcomes-of-pregnancy-at-39-weeks-and-beyond-with-mild-gestational-diabetes-mellitus
#4
Hanqing Chen, Suhua Zou, Jianbo Yang, Songqing Deng, Jian Cai, Zilian Wang
OBJECTIVES: The purpose of this study was to retrospectively analyze maternal and neonatal outcomes in pregnant women with mild gestational diabetes mellitus at 39 weeks compared to 40 weeks. MATERIAL AND METHODS: Clinical data of 372 cases of mild gestational diabetes mellitus form First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. There were 108 mild GDM patients that delivered at 40-40+6 weeks in our research group, and 264 patients that delivered in 39-39+6 weeks in the control group...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28817994/maternal-serum-and-fetal-cord-blood-ischemia-modified-albumin-concentrations-in-normal-pregnancy-and-preeclampsia-a-systematic-review-and-meta-analysis
#5
Varikasuvu Seshadri Reddy, Pragathi Duggina, Mrudula Vedhantam, Munikumar Manne, Neelakant Varma, Nagaram Srinivas
BACKGROUND/AIMS: A meta-analysis of maternal serum ischemia-modified albumin (IMA) and fetal cord blood IMA concentrations in normal pregnancy (NP) compared to nonpregnant healthy controls (HC) and in preeclampsia (PE) compared to normal pregnant controls were studied. METHODS: All major databases were searched for eligible studies. We included 8 studies comparing serum IMA between NP and HC, 14 studies comparing serum IMA between PE and NP and 5 studies comparing cord-blood IMA between PE and NP groups...
August 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28816612/protecting-pregnant-workers-while-fighting-sexism-work-pregnancy-balance-and-pregnant-nurses-resistance-in-qu%C3%A3-bec-hospitalsprot%C3%A3-ger-les-travailleuses-enceintes-en-luttant-contre-le-sexisme-%C3%A3-quilibre-travail-grossesse-et-r%C3%A3-sistance-d-infirmi%C3%A3-res-enceintes
#6
Anne Renée Gravel, Jessica Riel, Karen Messing
Women's workplaces should guarantee healthy pregnancies while supporting pregnant women as workers. In Québec (Canada), a pregnant worker exposed to a "danger" for herself or her fetus may ask her employer to be reassigned to other work appropriate to her skills. This approach differs from other regulatory contexts in North America in that protection of fetal and maternal health is embedded in the health and safety legislation. The advantage is that the pregnant worker is guaranteed access to her full salary, but some may question whether specific provisions for pregnant women single out such women and produce risks for their careers or, conversely, pregnancy should receive even more special consideration...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28816360/c-c-motif-chemokine-ligand-2-regulates-lps-induced-inflammation-and-er-stress-to-enhance-proliferation-of-bovine-endometrial-epithelial-cells
#7
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Sung-Man Kim, Gwonhwa Song
Chemokines play an important role in regulating the complex immune system at the maternal-fetal interface during pregnancy. Among various chemokines, C-C motif chemokine ligand 2 (CCL2) plays a role in the recruitment of immune regulatory cells to implantation sites within the endometrium. In cattle, CCL2 is abundantly expressed in the uterine endometrium. However, its intracellular signaling has not been identified. In this study, we examined the effects of CCL2 on bovine endometrial (BEND) cell proliferation...
August 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28815546/clusters-of-week-specific-maternal-gestational-weight-gain-pattern-and-their-association-with-birthweight-an-observational-cohort-study
#8
Huan Liang, Chuanmin Yin, Xinran Dong, Ganesh Acharya, Xiaotian Li
INTRODUCTION: Gestational weight gain (GWG) varies widely among different populations, and an inappropriate GWG is associated with adverse pregnancy outcomes. We aimed to investigate week-specific serial changes in GWG in an urban Chinese population to derive clusters of GWG pattern and explore the impact of GWG patterns on birthweight. MATERIAL AND METHODS: This was an observational cohort study of 6130 women delivered at a university hospital in Shanghai, China...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28814477/iodine-excess-exposure-during-pregnancy-and-lactation-impairs-maternal-thyroid-function-in-rats
#9
Caroline Serrano-Nascimento, Rafael Salgueiro, Kaio Vitzel, Thiago Urgal Pantaleao, Vania Maria Correa da Costa, Maria Tereza Nunes
Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Therefore, this study aimed to investigate the impact of IE exposure during pregnancy and lactation periods on maternal hypothalamus-pituitary-thyroid axis...
August 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28813528/maternal-and-fetal-risk-factors-for-stillbirth-in-northern-tanzania-a-registry-based-retrospective-cohort-study
#10
Francisca S Chuwa, Amasha H Mwanamsangu, Benjamin G Brown, Sia E Msuya, Elizabeth E Senkoro, Oresta P Mnali, Festo Mazuguni, Michael J Mahande
BACKGROUND: Stillbirth is a major cause of perinatal mortality and occurs disproportionately in developing countries including Tanzania. However, there is scant information regarding the predictors of this condition in Tanzania. This study aimed to determine maternal and fetal risk factors for stilbirth in northen Tanzania. METHODOLOGY: A retrospective cohort study was performed using maternally-linked data from the Kilimanjaro Christian Medical Centre birth registry...
2017: PloS One
https://www.readbyqxmd.com/read/28811141/the-pharmacokinetic-profile-of-synthetic-cathinones-in-a-pregnancy-model
#11
Lauren G Strange, Kerri Kochelek, Robert Keasling, Stacy D Brown, Brooks B Pond
In recent years, the abuse of synthetic cathinones or 'bath salts' has become a major public health concern. Although these compounds were initially sold legally and labeled "not for human consumption", the 'bath salts' are psychostimulants, with similar structures and pharmacologic mechanisms to cocaine, the amphetamines, and 3,4 methylendioxymethamphetamine (MDMA, Molly, or Ecstasy). The reported use of these substances by women of child-bearing age highlights the necessity of studies seeking to delineate risks of prenatal exposure...
August 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28810692/resveratrol-protects-from-lipopolysaccharide-induced-inflammation-in-the-uterus-and-prevents-experimental-preterm-birth
#12
María Victoria Bariani, Fernando Correa, Emma Leishman, Ana Paula Domínguez Rubio, Andreína Arias, Aníbal Stern, Heather B Bradshaw, Ana María Franchi
STUDY QUESTION: Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? SUMMARY ANSWER: Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. WHAT IS KNOWN ALREADY: Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28809844/the-4-vessel-sampling-approach-to-integrative-studies-of-human-placental-physiology-in-vivo
#13
Ane M Holme, Maia B Holm, Marie C P Roland, Hildegunn Horne, Trond M Michelsen, Guttorm Haugen, Tore Henriksen
The human placenta is highly inaccessible for research while still in utero. The current understanding of human placental physiology in vivo is therefore largely based on animal studies, despite the high diversity among species in placental anatomy, hemodynamics and duration of the pregnancy. The vast majority of human placenta studies are ex vivo perfusion studies or in vitro trophoblast studies. Although in vitro studies and animal models are essential, extrapolation of the results from such studies to the human placenta in vivo is uncertain...
August 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28808675/acute-appendicitis-in-pregnancy-and-the-developing-world
#14
Tika Ram Bhandari, Sudha Shahi, Sarita Acharya
BACKGROUND: Acute appendicitis is the commonest nonobstetric surgical emergency during pregnancy. The aim of the study was to compare perioperative outcomes of acute appendicitis in pregnant and nonpregnant patients. METHODS: A retrospective review of medical records of 56 pregnant patients between 2011 and 2016 who were compared with 164 nonpregnant women of reproductive age who underwent open appendectomy between 2014 and 2016 for acute appendicitis. The patient's demographics and perioperative data were analyzed...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28808585/spinal-cord-injury-during-the-second-trimester-of-pregnancy
#15
Ahmad Zaheer Qureshi, Sami Ullah, Anas Jehad AlSaleh, Rubina' Ullah
INTRODUCTION: Pregnancies in women with spinal cord injury (SCI) are at greater risk of morbidity and mortality. Although pregnancy after SCI is well elaborated in the literature, SCI occurring during pregnancy is rarely reported. Abrupt changes in the body physiology because of SCI and the resulting disability add a risk to maternal and fetal well-being. Not only is the burden of care increased but there is also a higher risk of developing pressure ulcers, urinary tract infections, autonomic instability, intrauterine growth retardation and venous thromboembolism...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28807719/maternal-hypothyroidism-an-overview-of-current-experimental-models
#16
REVIEW
Mahboubeh Ghanbari, Asghar Ghasemi
Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. To obtain comparable results with different clinical conditions, which lead to MH in humans, several factors have been suggested for researchers to consider before designing the experimental models. Regarding development of fetal body systems during pregnancy, interference at different times provides different results and the appropriate time for induction of hypothyroidism should be selected based on accurate time of development of the system under assessment...
August 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28807280/immunization-with-inactivated-antigens-of-neospora-caninum-induces-toll-like-receptors-3-7-8-and-9-in-maternal-fetal-interface-of-infected-pregnant-heifers
#17
M S Marin, Y P Hecker, S Quintana, S E Pérez, M R Leunda, G J Cantón, E R Cobo, D P Moore, A C Odeón
Neospora caninum is an obligate parasite and a major cause of abortion in cattle. Pregnancy failures appear to be associated with weak innate defences on the maternal-fetal interface during infection with N. caninum. Herein, we studied the gene expression of Toll-like receptors (TLRs) in pregnant heifers immunized with different vaccine formulations against N. caninum before mating and then challenged the heifers with live N. caninum on day 70 of gestation. TLR7 and TLR8 expression was upregulated in the placental caruncle of infected-pregnant heifers previously exposed to live N...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806624/bcl-2-bax-protein-and-mrna-expression-in-yak-bos-grunniens-placentomes
#18
JiangFeng Fan, SiJiu Yu, Yan Cui, Gengquan Xu, Libin Wang, Yangyang Pan, Honghong He
Placental function is complex and influenced by various factors; furthermore, it depends on a delicate balance between cell proliferation, cell differentiation, and cell death. Bcl-2 and Bax proteins are key apoptosis regulators and are considered to play an important role in the maintenance of both dynamic balance and integrity of many tissues. Changes in Bcl-2 and Bax expressions have been described during different developmental stages in normal human placentas. Studies furthermore indicated several pathological placental changes to be related to abnormal Bcl-2 and Bax expressions...
July 29, 2017: Theriogenology
https://www.readbyqxmd.com/read/28805341/treatment-options-for-severe-pulmonary-embolism-during-pregnancy-and-the-postpartum-period-a-systematic-review
#19
G Martillotti, F Boehlen, H Robert-Ebadi, N Jastrow, M Righini, M Blondon
BACKGROUND: Massive pulmonary embolism (PE) during pregnancy or the postpartum period is a rare but dramatic event. Our aim was to systematically review the evidence to guide its management. METHODS: We searched Pubmed, Embase, conference proceedings and the RIETE registry for published cases of severe (submassive/massive) PE treated with thrombolysis, percutaneous or surgical thrombectomy and/or with ECMO, occurring during pregnancy or within 6 weeks of delivery...
August 14, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28805116/bisphenol-a-and-adverse-pregnancy-outcomes-a-systematic-review-of-the-literature
#20
Vasilios Pergialiotis, Paraskevi Kotrogianni, Evangelos Christopoulos-Timogiannakis, Diamanto Koutaki, Georgios Daskalakis, Nikolaos Papantoniou
PURPOSE: Bisphenol A is a chemical compound related to adverse maternal and neonatal outcomes. The purpose of the present systematic review is to summarize current knowledge in the field. MATERIALS AND METHODS: We systematically searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases. RESULTS: Thirty-five studies were included in the present systematic review...
August 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
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