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https://www.readbyqxmd.com/read/29028516/pravastatin-to-treat-and-prevent-preeclampsia-preclinical-and-clinical-studies
#1
Guillermina Girardi
Pre-eclampsia is a disease of pregnancy affecting 5%-8% of all pregnancies and a leading cause of maternal and fetal mortality. Despite improvements in the diagnosis, there is no effective method for prevention and treatment. While studies in women are of critical importance, investigation of pathological mechanisms in pregnant women is necessarily limited, and the ability to establish cause and effect relationships, difficult. Mouse models have been instrumental in defining pathogenic mechanisms in preeclampsia and in the identification of pravastatin as a potential treatment to prevent pregnancy complications associated with placental dysfunction...
September 29, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29026065/urethral-diverticulum-presenting-as-a-large-vaginal-mass-complicating-pregnancy-and-delivery
#2
Everett F Magann, Lisa S Newton, Susan A Barr
BACKGROUND A case report of urethral diverticulum complicating pregnancy is presented. The diagnosis and management are challenging because of the rare nature of this condition, the varied presentations and differential diagnoses, and the possibility of misdiagnosis. CASE REPORT A 25-year-old primigravida with scheduled induction of labor at 39 weeks gestation due to gestational diabetes mellitus presented for a routine antenatal appointment at 38 weeks and four days. On digital cervical examination, she was found to have a large semi-solid anterior vaginal mass, shown by trans-vaginal ultrasound to have a nearly solid appearance of a 5×7 cm mass with septation...
October 13, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29025835/the-climb-complex-lipids-in-mothers-and-babies-study-protocol-for-a-multicentre-three-group-parallel-randomised-controlled-trial-to-investigate-the-effect-of-supplementation-of-complex-lipids-in-pregnancy-on-maternal-ganglioside-status-and-subsequent-cognitive
#3
Shuai Huang, Ting-Ting Mo, Tom Norris, Si Sun, Ting Zhang, Ting-Li Han, Angela Rowan, Yin-Yin Xia, Hua Zhang, Hong-Bo Qi, Philip N Baker
INTRODUCTION: Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk lipids (CML) in pregnancy may increase the level of fetal gangliosides (GA), with the potential to improve cognitive outcomes. METHODS AND ANALYSIS: We aim to recruit approximately 1500 pregnant women in the first trimester (11-14 weeks) and randomise them into one of the three treatment groups: standard maternal milk formulation, CML-enhanced maternal milk formulation or no maternal milk intervention with standard pregnancy advice (ie, the standard care)...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025527/-being-a-mother-after-35-years-will-it-be-different
#4
Bárbara Marques, Francisca Palha, Edgar Moreira, Sandra Valente, Margarida Abrantes, Joana Saldanha
INTRODUCTION: Advanced maternal age is defined as maternity after 35 years old and is associated with more complications during pregnancy and neonatal period as well as decreased fertility. This study aims to examine the relationship between advanced maternal age and their maternal and fetal consequences, as well as maternal perception of the risk of pregnancy after 35 years old. MATERIAL AND METHODS: Observational, retrospective and comparative study, between two groups: advanced maternal age group (aged ≥ 35 years) and non-advanced maternal age group (age < 35 years), conducted between March and June 2015...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025051/integrating-behavioral-health-risk-assessment-into-centralized-intake-for-maternal-and-child-health-services
#5
Sarah Kye Price, D Crystal Coles, Tracey Wingold
Effectively promoting women's health during and around the time of pregnancy requires early, nonstigmatizing identification and assessment of behavioral health risks (such as depression, substance use, smoking, and interpersonal violence) combined with timely linkage to community support and specialized interventions. This article describes an integrated approach to behavioral health risk screening woven into a point of first contact with the health care delivery system: centralized intake for maternal and child health home visiting programs...
September 4, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29023968/pregnant-metaphors-and-surrogate-meanings-bringing-the-ethnography-of-pregnancy-and-surrogacy-into-conversation-in-israel-and-beyond
#6
Tsipy Ivry, Elly Teman
This article explores the way that surrogacy and normal pregnancy share cultural assumptions about pregnancy. Through a juxtaposition of our ethnographic studies of two groups of Jewish-Israeli women-women who have undergone "normal," low-risk pregnancies and women who have given birth as gestational surrogates-we argue that surrogacy and pregnancy emerge as potent metaphors for one another. Both pregnant women and surrogates divided their bodies into two separate realms: fetus and maternal pregnant body. Both trivialized the effect of gestational influence on fetal health, making the fetus seem detached from gestational capacities of the mother...
October 11, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/29023736/an-investigation-of-fetal-behavioural-states-during-maternal-sleep-in-healthy-late-gestation-pregnancy-an-observational-study
#7
Peter R Stone, Wendy Burgess, Jordan McIntyre, Alistair J Gunn, Christopher A Lear, Laura Bennet, Edwin A Mitchell, John M D Thompson
BACKGROUND: Fetal behavioural states (FBS) are measures of fetal wellbeing. Maternal position affects FBS with supine being associated with an increased likelihood of fetal quiescence consistent with the human fetus adapting to a lower oxygen consuming state. A number of studies now confirm the association of sleep position with risk of late intrauterine death. We designed this study to observe the effects of maternal sleep positions overnight in healthy late gestation pregnancy. METHOD: Twenty nine healthy women had continuous fetal ECG recordings overnight...
October 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29022925/anti-cytomegalovirus-immunoglobulin-m-titer-for-congenital-infection-in-first-trimester-pregnancy-with-primary-infection-a-multicenter-prospective-cohort-study
#8
K Toriyabe, F Morikawa, T Minematsu, M Ikejiri, S Suga, T Ikeda
OBJECTIVE: We evaluated cytomegalovirus (CMV) immunoglobulin M (IgM) titer in pregnant women with primary infection as a predictive factor for congenital infection. STUDY DESIGN: Maternal CMV antibody screening during the first trimester was conducted prospectively at 16 centers in Japan between September 2013 and 2015. Women with confirmed maternal primary infection underwent testing for fetal congenital infection, and we investigated the positive predictive value of CMV IgM titer levels for congenital infection in women with a low IgG avidity...
October 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29022924/listeriosis-in-pregnancy-under-diagnosis-despite-over-treatment
#9
Y Fouks, S Amit, A Many, A Haham, D Mandel, S Shinar
OBJECTIVE: To compare the symptomatology of pregnant women with suspected listeriosis to culture confirmed listeriosis. STUDY DESIGN: All cases of suspected and culture confirmed pregnancy-associated listeriosis from a single center were retrospectively reviewed assessing demographics, clinical, laboratory and pathological findings, and maternal, fetal and neonatal outcomes. RESULTS: Listeriosis was identified in seven patients, none of whom belonged to the 117 women with suspected listeriosis...
October 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29022922/rankl-mediated-harmonious-dialogue-between-fetus-and-mother-guarantees-smooth-gestation-by-inducing-decidual-m2-macrophage-polarization
#10
Yu-Han Meng, Wen-Jie Zhou, Li-Ping Jin, Li-Bing Liu, Kai-Kai Chang, Jie Mei, Hui Li, Jian Wang, Da-Jin Li, Ming-Qing Li
Decidual macrophages (dMϕ) contribute to maternal-fetal tolerance. However, the mechanism of dMϕ differentiation during pregnancy is still largely unknown. Here, we report that receptor activator for nuclear factor-κ B ligand (RANKL), secreted by human embryonic trophoblasts and maternal decidual stromal cells (DSCs), polarizes dMϕ toward a M2 phenotype. This polarization is mediated through activation of Akt/signal transducer and activator of transcription 6 (STAT6) signaling, which is associated with the upregulation of histone H3 lysine-27 demethylase Jmjd3 and IRF4 in dMϕ...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022513/discrepancies-in-animal-models-of-preterm-birth
#11
Clarence R Manuel, Charles R Ashby, Sandra E Reznik
BACKGROUND: Preterm birth (PTB) is a multifactorial syndrome occurring before the 37th week of full-term pregnancy [1]. Babies delivered preterm experience short-term and long-term complications affecting multiple organ systems, and serious maternal complications include hemorrhage and infection. Each year, an estimated 15 million babies are born preterm, and complications from prematurity are the leading cause of death among children up to 5 years of age [2]. With another increase in PTB rates over the last several years, the United States continues to have the highest incidence of any industrialized country [3]...
October 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29020789/-the-role-of-maternal-imunity-and-woman%C3%A2-s-microbiome-in-the-pathogenesis-of-preterm-labor
#12
M Koucký, K Malíčková, J Hrdý, A Černý, H Hrbáčková, P Šimják, A Pařízek
OBJECTIVE: To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice. SETTING: Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital. DESIGN: Review article. METHODS: Compilation od published data from scientific literature. CONCLUSION: Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29020697/effect-of-maternal-age-and-fetal-number-on-the-risk-of-hypertensive-disorders-of-pregnancy
#13
Devin D Smith, Audrey A Merriam, Julley Jung, Cynthia Gyamfi-Bannerman
No abstract text is available yet for this article.
October 11, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29020282/elevated-levels-of-estradiol-in-hiv-positive-pregnant-women-on-protease-inhibitor-based-regimens
#14
Kayode A Balogun, Monica Guzman Lenis, Eszter Papp, Mona Loutfy, Mark H Yudin, Jay MacGillivray, Sharon L Walmsley, Michael Silverman, Lena Serghides
Background: HIV-positive pregnant women on protease inhibitor (PI)-based combination antiretroviral therapy (cART) have a greater risk for adverse birth outcomes, and an association with steroid hormone levels has been implicated. The objective of this study was to investigate the association between PI-cART and estradiol levels in pregnancy. Methods: Fifty-five HIV-positive and 49 HIV-negative Canadian pregnant women were followed prospectively throughout gestation...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018972/birth-management-and-fetal-outcome-in-multiple-gestation-analysis-of-1-444-births
#15
S Fill Malfertheiner, M Weigl, A Dudakova, B Seelbach-Göbel
PURPOSE: Since the late 1990s, controversies came up concerning the mode of delivery for multiples births. The twin birth study indicated no difference in maternal and fetal outcome between planned vaginal delivery and planned caesarean section, but did not analyze the influence of maternal and fetal characteristics or the obstetric management in vaginal birth. The purpose of this study is to analyze these parameters regarding fetal outcome. METHODS: A large-scale retrospective analysis of twin births (n = 1...
October 10, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29017990/healthy-beyond-pregnancy-a-web-based-intervention-to-improve-adherence-to-postpartum-care-randomized-controlled-feasibility-trial
#16
Katherine Park Himes, Heidi Donovan, Stephanie Wang, Carrie Weaver, Jillian Rae Grove, Francesca Lucia Facco
BACKGROUND: During the postpartum visit, health care providers address issues with short- and long-term implications for maternal and child health. Women with Medicaid insurance are less likely to return for a postpartum visit compared with women with private insurance. Behavioral economics acknowledges that people do not make exclusively rational choices, rather immediate gratification, cognitive and psychological biases, and social norms influence decision making. Drawing on insights from decision science, behavioral economists have examined how these biases can be modulated through carefully designed interventions...
October 10, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29017438/hsd11b2-runx3-and-line-1-methylation-in-placental-dna-of-hypertensive-disorders-of-pregnancy-patients
#17
Aleksandra Majchrzak-Celińska, Katarzyna Kosicka, Julia Paczkowska, Franciszek K Główka, Grzegorz H Bręborowicz, Mariola Krzyścin, Anna Siemiątkowska, Marcin Szaumkessel, Wanda Baer-Dubowska
Hypertensive Disorders of Pregnancy (HDsP) remain leading causes of maternal and perinatal morbidity and mortality. Growing evidence suggests the involvement of epigenetic factors, such as gene-specific and global DNA methylation changes, both in the etiology and as an effect of HDsP. In this study, we investigated the potential association between placental DNA methylation status in selected CpGs of HSD11B2 cortisol level controlling gene, RUNX3 tumor suppressor gene, and long interspersed nucleotide element-1 (LINE-1) repetitive elements and HDsP-preeclampsia (PE), gestational hypertension (GH), and chronic hypertension (CH)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017154/screening-performance-of-placental-growth-factor-for-the-prediction-of-low-birth-weight-and-adverse-intrapartum-and-neonatal-outcomes-in-a-term-low-risk-population
#18
Larissa N Bligh, Ristan M Greer, Sailesh Kumar
INTRODUCTION: Fetuses who fail to reach their genetic growth potential are thought to have sub-optimal placental function. Low placental growth factor (PlGF) levels have been shown to be predictive of placentally mediated conditions, such as pre-eclampsia or fetal growth restriction. We investigated the screening performance of PlGF for the prediction of low birth weight (<10th centile for gestation) and adverse intrapartum and neonatal outcomes in apparently low-risk term pregnancies...
October 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#19
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29016512/trial-of-labor-compared-with-cesarean-delivery-in-superobese-women
#20
Jennifer L Grasch, Jennifer L Thompson, J Michael Newton, Amy W Zhai, Sarah S Osmundson
OBJECTIVE: To examine whether labor compared with planned cesarean delivery is associated with increased maternal and neonatal morbidity. METHODS: We conducted a retrospective cohort study of all women with body mass indexes (BMIs) at delivery of 50 or greater delivering a live fetus at 34 weeks of gestation of greater between January 1, 2008, and December 31, 2015. Pregnancies with multiple gestations and major fetal anomalies were excluded. The primary outcome was a composite of maternal and neonatal morbidity and was estimated to be 50% in superobese women based on institutional data...
October 6, 2017: Obstetrics and Gynecology
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