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Diabetic cerebrovascular disease

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https://www.readbyqxmd.com/read/27919487/inverse-comorbidity-in-multiple-sclerosis-findings-in-a-complete-nationwide-cohort
#1
Anja Thormann, Nils Koch-Henriksen, Bjarne Laursen, Per Soelberg Sørensen, Melinda Magyari
BACKGROUND: Inverse comorbidity is disease occurring at lower rates than expected among persons with a given index disease. The objective was to identify inverse comorbidity in MS. METHODS: We performed a combined case-control and cohort study in a total nationwide cohort of cases with clinical onset of MS 1980-2005. We randomly matched each MS-case with five population controls. Comorbidity data were obtained from multiple, independent nationwide registries. Cases and controls were followed from January 1977 to the index date, and from the index date through December 2012...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27917464/relation-of-dysglycemia-to-structural-brain-changes-in-a-multiethnic-elderly-cohort
#2
Christiane Reitz, Vanessa A Guzman, Atul Narkhede, Charles DeCarli, Adam M Brickman, José A Luchsinger
OBJECTIVES: Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The objective of this study was to examine the relation of dysglycemia clinical categories (normal glucose tolerance (NGT), pre-diabetes, undiagnosed diabetes, known diabetes) with brain structure in older adults. We also assessed the relation between dysglycemia and cognitive performance...
December 5, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27909151/cerebrovascular-disease-associated-risk-factors-and-antithrombotic-therapy-in-a-population-screening-cohort-insights-from-the-belgian-heart-rhythm-week-programme
#3
Marco Proietti, Georges H Mairesse, Peter Goethals, Christophe Scavee, Johan Vijgen, Ivan Blankoff, Yves Vandekerckhove, Gregory Yh Lip
BACKGROUND: Cerebrovascular disease confers a major healthcare burden worldwide and is a major cause of death and disability. Several well-established risk factors, such as atrial fibrillation (AF), are associated with cerebrovascular disease and antithrombotic therapy reduces risk. DESIGN: This study was a subgroup analysis from the Belgian Heart Rhythm Week, a nationwide AF awareness programme. METHODS: We studied subjects screened between 2012 and 2014 with available data on clinical risk factors and antithrombotic treatment...
December 1, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27905161/the-impact-of-co-morbidity-burden-on-appropriate-implantable-cardioverter-defibrillator-therapy-and-all-cause-mortality-insight-from-danish-nationwide-clinical-registers
#4
Anne Christine Ruwald, Michael Vinther, Gunnar H Gislason, Jens Brock Johansen, Jens Cosedis Nielsen, Helen Høgh Petersen, Sam Riahi, Christian Jons
AIMS: In a nationwide cohort of primary (PP-ICD) and secondary prevention (SP-ICD) implantable cardioverter defibrillator (ICD) patients, we aimed to investigate the association between co-morbidity burden and risk of appropriate ICD therapy and mortality. METHODS AND RESULTS: We identified all patients >18 years, implanted with first-time PP-ICD (n = 1873) or SP-ICD (n = 2461) in Denmark from 2007 to 2012. Co-morbidity was identified in administrative registers of hospitalization and drug prescription from pharmacies...
December 1, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27889950/retinopathy-a-sign-of-cerebral-small-vessel-disease-in-diabetes
#5
Toshitaka Umemura, Takahiko Kawamura
Cardio-cerebrovascular disease greatly influences the prognosis of diabetic patients. Silent lacunar infarcts, white matter lesions (WMLs), and cerebral microbleeds are magnetic resonance imaging (MRI) markers of cerebral small vessel disease (SVD) and as they are associated with stroke and dementia, prevention of their incidence and progression is important in clinical practice. The findings of previous autopsy and clinical studies suggest that lacunar infarcts are more prevalent in diabetic patients. On the other hand, the findings of studies on an association between diabetes and WMLs have been inconsistent...
November 27, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27879488/18f-naf-pet-demonstrating-unusual-focal-tracer-activity-in-the-brain
#6
Anuradha Thenkondar, Lida Jafari, Robbie Sooriash, Fereshteh Hajsadeghi, Gholam R Berenji, Yuxin Li
A 60-year-old man with enlarged prostate, hypertension, and diabetes was referred for F-NaF PET/CT to evaluate possible metastatic lesions. The patient appeared asymptomatic on the day of the study, without any signs indicating stroke. Patient also had no known history of malignancy or cerebrovascular disease. He had mild elevation of the prostate-specific antigen level, and biopsy of his prostate was not performed. Patient had long-standing history of chronic back pain and abdominal pain. The PET bone scan demonstrated a large area of very intense tracer uptake in the brain...
November 22, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27875539/secular-trends-in-admissions-and-mortality-rates-from-diabetes-mellitus-in-the-central-belt-of-ghana-a-31-year-review
#7
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Benjamin Eghan, Nana Kwame Ayisi-Boateng, Emmanuel Acheamfour-Akowuah
INTRODUCTION: Diabetes Mellitus is currently a leading cause of morbidity and mortality throughout the world, particularly in sub-Saharan Africa where a significant proportion of diabetes cases are now found. Longitudinal profiling of in-patient admissions and mortality trends from diabetes provide useful insights into the magnitude of the burden of diabetes, serve as a sentinel on the state of out-patient diabetes care and provide effective tools for planning, delivering and evaluating the health care needs relating to the disease in sub-Saharan Africa...
2016: PloS One
https://www.readbyqxmd.com/read/27862654/cerebral-small-vessel-disease-medial-temporal-lobe-atrophy-and-cognitive-status-in-patients-with-ischaemic-stroke-and-transient-ischaemic-attack
#8
F Arba, T Quinn, G J Hankey, M Ali, K R Lees, D Inzitari
BACKGROUND AND PURPOSE: Small vessel disease (SVD) and Alzheimer's disease (AD) are two common causes of cognitive impairment and dementia, traditionally considered as distinct processes. The relationship between radiological features suggestive of AD and SVD was explored, and the association of each of these features with cognitive status at 1 year was investigated in patients with stroke or transient ischaemic attack. METHODS: Anonymized data were accessed from the Virtual International Stroke Trials Archive (VISTA)...
November 14, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27856785/chronic-obstructive-pulmonary-disease-phenotypes-using-cluster-analysis-of-electronic-medical-records
#9
Rodrigo Vazquez Guillamet, Oleg Ursu, Gary Iwamoto, Pope L Moseley, Tudor Oprea
Chronic obstructive pulmonary disease is a heterogeneous disease. In this retrospective study, we hypothesize that it is possible to identify clinically relevant phenotypes by applying clustering methods to electronic medical records. We included all the patients >40 years with a diagnosis of chronic obstructive pulmonary disease admitted to the University of New Mexico Hospital between 1 January 2011 and 1 May 2014. We collected admissions, demographics, comorbidities, severity markers and treatments...
November 17, 2016: Health Informatics Journal
https://www.readbyqxmd.com/read/27851838/trends-and-outcomes-of-pulmonary-arterial-hypertension-related-hospitalizations-in-the-united-states-analysis-of-the-nationwide-inpatient-sample-database-from-2001-through-2012
#10
Vidhu Anand, Samit S Roy, Stephen L Archer, E Kenneth Weir, Sushil Kumar Garg, Sue Duval, Thenappan Thenappan
Importance: Recent trends and outcomes of pulmonary arterial hypertension (PAH)-related hospitalization in adults in the United States are unknown. Objective: To examine the characteristics of PAH-related hospitalizations. Design, Setting, and Participants: We analyzed the National Inpatient Sample database for all adult patients (≥18 years old) with PAH as the principal discharge diagnosis from January 1, 2001, through December 31, 2012...
November 16, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27849379/lower-serum-25-hydroxyvitamin-d-is-associated-with-obesity-but-not-common-chronic-conditions-an-observational-study-of-african-american-and-caucasian-male-veterans
#11
Jacqueline L Cartier, Subhash C Kukreja, Elena Barengolts
Objective The study examined whether vitamin D insufficiency is a predictor of prevalent and/or incident common chronic conditions in African American men (AAM) and Caucasian men (CAM). Methods 1,017 men were recruited at an urban VA medical center and followed prospectively for a mean of 5.4 years. Prevalent and incident chronic conditions evaluated were: obesity, type 2 diabetes (T2D), cancer, depression, dementia, and cardiovascular disease (CVD, including coronary artery disease [CAD], cerebrovascular accident [CVA], and congestive heart failure [CHF])...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27845997/impact-of-diabetes-duration-on-3-year-clinical-outcomes-following-coronary-revascularization
#12
Hai-Yang Gao, Er-Li Zhang, Qing-Rong Liu, Hong-Qiu Gu, Heng Zhang, Zhe Zheng, Yue-Jin Yang, Run-Lin Gao, Yong-Jian Wu
OBJECTIVE: The aim of this study was to evaluate the impact of diabetes duration on long-term clinical outcomes after drug-eluting stent (DES) implantation or coronary artery bypass grafting (CABG). METHODS: A total of 820 diabetic patients treated with initial DES (n=451) or CABG (n=369) were consecutively enrolled in this single-center follow-up study. The main outcomes included major adverse cardiac events and major adverse cardiac or cerebrovascular events (MACCEs)...
November 11, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27843655/moyamoya-disease-with-coexistent-hypertriglyceridemia-in-pediatric-patient
#13
Jacqueline Chan, Fabiola D'Ambrosio Rodriguez, Deepank Sahni, Claudia Boucher-Berry
Moyamoya disease is a rare chronic and progressive cerebrovascular disease of the arteries of the circle of Willis that can affect children and adults. It has been associated with multiple diseases, including immunologic, like Graves' disease, diabetes mellitus, and SLE. Hyperlipidemia has been recognized in patients with Moyamoya disease with an incidence of 27-37%. However, no case in pediatric patients has been reported of the coexistence of Moyamoya disease and hyperlipidemia. Here we present a case of a 9-year-old female diagnosed with Moyamoya disease after a stroke with incidental finding of familial hypercholesterolemia...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27833378/cardiovascular-risk-after-orthotopic-liver-transplantation-a-review-of-the-literature-and-preliminary-results-of-a-prospective-study
#14
REVIEW
Giuseppina Pisano, Anna L Fracanzani, Lucio Caccamo, Maria F Donato, Silvia Fargion
Improved surgical techniques and greater efficacy of new anti-rejection drugs have significantly improved the survival of patients undergoing orthotopic liver transplantation (OLT). This has led to an increased incidence of metabolic disorders as well as cardiovascular and cerebrovascular diseases as causes of morbidity and mortality in OLT patients. In the last decade, several studies have examined which predisposing factors lead to increased cardiovascular risk (i.e., age, ethnicity, diabetes, NASH, atrial fibrillation, and some echocardiographic parameters) as well as which factors after OLT (i...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27830026/puerarin-inhibits-cardiac-fibrosis-via-monocyte-chemoattractant-protein-mcp-1-and-the-transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-pathway-in-myocardial-infarction-mice
#15
Zhiwen Tao, Yingbin Ge, Ningtian Zhou, Yunle Wang, Weili Cheng, Zhijian Yang
Transforming growth factor-β1 (TGF-β1) and inflammation play important roles in the cardiac fibrosis development associated with myocardial infarction (MI). Puerarin is wildly used for treatment of diabetes, cardiovascular disease and cerebrovascular disease in China, and recently some studies have shown its anti-cardiac fibrotic effect on myocardial hypertrophy. The purpose of our study was to determine whether puerarin has an anti-cardiac fibrotic effect after MI and find the potential mechanism. A mouse model of MI was established by standard LAD coronary artery ligation, and cardiac fibrosis was confirmed by Masson's staining and the expression of collagen I, III and α-SMA...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27828975/end-stage-renal-disease-predicts-increased-risk-of-death-in-first-degree-relatives-in-the-norwegian-population
#16
Rannveig Skrunes, Einar Svarstad, Anna Varberg Reisæter, Hans-Peter Marti, Bjørn Egil Vikse
BACKGROUND: Increased risk of end stage renal disease (ESRD) and death in Norwegian living kidney donors has been reported, most of the donors were related to the recipient. The present study investigates risk of death in first degree relatives of ESRD patients. METHODS: The Norwegian Population Registry, The Norwegian Cause of Death Registry and the Norwegian Renal Registry were linked. All citizens born in Norway, alive in 1960 and with at least one registered first degree relative were included; individuals who died during the first year of life were excluded...
2016: PloS One
https://www.readbyqxmd.com/read/27824916/association-between-functional-capacity-decline-and-nutritional-status-based-on-the-nutrition-screening-initiative-checklist-a-2-year-cohort-study-of-japanese-community-dwelling-elderly
#17
Yumiko Sugiura, Yoshimi Tanimoto, Ayumi Imbe, Yuiko Inaba, Satoshi Sakai, Kanako Shishikura, Keiji Tanimoto, Toshiaki Hanafusa
AIM: To assess whether nutritional status based on the Nutrition Screening Initiative Checklist is useful for predicting functional capacity decline in community-dwelling Japanese elderly. METHODS: This two-year observational cohort study included 536 community-dwelling Japanese (65 years and older at baseline) who were independent in both activities and instrumental activities of daily living. Demographic attributes, chronic illness, lifestyle-related habits, nutritional status, functional capacity, and anthropometric measurements were assessed, with decline in functional capacity used as the outcome measure...
2016: PloS One
https://www.readbyqxmd.com/read/27809453/long-term-study-of-the-association-of-adipokines-and-glucose-variability-with-diabetic-complications
#18
Jin Joo Cha, Hye Sook Min, Kitae Kim, Mi Jin Lee, Mi Hwa Lee, Jung Eun Kim, Hye Kyoung Song, Dae Ryong Cha, Young Sun Kang
Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit-to-visit glucose variability were measured in diabetic patients...
November 4, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27803140/rate-of-comorbidities-in-giant-cell-arteritis-a-population-based-study
#19
Aladdin J Mohammad, Martin Englund, Carl Turesson, Gunnar Tomasson, Peter A Merkel
OBJECTIVE: To compare the rate of occurrence of comorbidities, including severe infections, in a population-based cohort of patients with biopsy-proven giant cell arteritis (GCA) with a reference population in Southern Sweden. METHODS: The study included a population-based cohort of biopsy-proven GCA cases diagnosed between 1998 and 2010 from the Skåne region in Southern Sweden (population: 1.2 million). For each patient, 4 reference subjects were identified from the general population and matched for age, sex, area of residence, and date of diagnosis of GCA...
November 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27801932/antidepressant-exposure-and-risk-of-dementia-in-older-adults-with-major-depressive-disorder
#20
Joy E Brodrick, Monica L Mathys
OBJECTIVES: To identify whether duration of antidepressant use in depressed elderly veterans differed between those who later developed dementia and those who did not. DESIGN: Single-center, retrospective, observational, electronic chart review. SETTING: Medical charts from a Veterans Affairs Mental Health Clinic. PARTICIPANTS: Veterans aged 65 and older with history of depression. MEASUREMENTS: Information on sociodemographic characteristics; duration of antidepressant, antipsychotic, and benzodiazepine therapy; diagnosis of dementia; and comorbid disease states was collected...
November 1, 2016: Journal of the American Geriatrics Society
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