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Diabetic cerebrovascular disease

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https://www.readbyqxmd.com/read/29240808/altered-cerebral-hemodyamics-and-cortical-thinning-in-asymptomatic-carotid-artery-stenosis
#1
Randolph S Marshall, Iris Asllani, Marykay A Pavol, Ying-Kuen Cheung, Ronald M Lazar
Cortical thinning is a potentially important biomarker, but the pathophysiology in cerebrovascular disease is unknown. We investigated the association between regional cortical blood flow and regional cortical thickness in patients with asymptomatic unilateral high-grade internal carotid artery disease without stroke. Twenty-nine patients underwent high resolution anatomical and single-delay, pseudocontinuous arterial spin labeling magnetic resonance imaging with partial volume correction to assess gray matter baseline flow...
2017: PloS One
https://www.readbyqxmd.com/read/29240062/-carotid-revascularization-in-type-2-diabetes-mellitus-significance-of-chronic-hyperglycaemia
#2
M M Tanashian, S I Skrylev, K V Antonova, R B Medvedev
Patients with type 2 diabetes mellitus (type 2 DM) are typically prone to the development of cerebral atherosclerosis. Presented herein are the results of examination of patients suffering from ischaemic cerebrovascular diseases on the background of type 2 DM subjected to open surgical or endovascular interventions. In patients with cerebrovascular pathology and type 2 DM, atherosclerosis progresses on the background of chronic hyperglycaemia combined with dyslipidaemia, leading to increased incidence of the development of cerebral circulatory impairments and detection of the indications for carrying out angioreconstructive operations on the internal carotid arteries...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29239331/ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-are-risk-factors-for-ischemic-stroke-in-patients-with-type-2-diabetes
#3
Ting Li, Xiu-Juan Wu, Xiao-Min Chen, Si-Bo Wang, Kang-Ding Liu, Ying-Qi Xing
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity (BaPWV) and ankle-brachial index (ABI) are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group (n = 55) and a diabetes and ischemic stroke group (n = 62)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29237922/outcomes-of-coronary-artery-bypass-graft-surgery-versus-percutaneous-coronary-intervention-in-patients-aged-18-45-years-with-diabetes-mellitus
#4
Yang Li, Ran Dong, Kun Hua, Tao-Shuai Liu, Shao-You Zhou, Ning Zhou, Hong-Jia Zhang
BACKGROUND: Debate on treatment for young patients with coronary artery disease still exists. This study aimed to investigate the intermediate- and long-term outcomes between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in patients aged 18-45 years with diabetes mellitus (DM). METHODS: Between January 2006 and March 2016, a total of 2018 DM patients aged 18-45 years including 517 cases of CABG and 1501 cases of PCI were enrolled in the study...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29235984/deaths-leading-causes-for-2015
#5
Melonie Heron
Objectives-This report presents final 2015 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements "Deaths: Final Data for 2015," the National Center for Health Statistics' annual report of final mortality statistics. Methods-Data in this report are based on information from all death certificates filed in the 50 states and the District of Columbia in 2015. Causes of death classified by the International Classification of Diseases, Tenth Revision (ICD-10) are ranked according to the number of deaths assigned to rankable causes...
November 2017: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29235658/baseline-characteristics-and-outcomes-of-older-adults-seeking-care-in-ambulatory-urgent-care-clinics
#6
Bernardo J Reyes, Javier M Lopez, Diana J Galindo, Maria Briceno, Joseph G Ouslander
OBJECTIVES: To determine the most common clinical conditions associated with older adults visiting Urgent care centers (UCCs) and the potential need for further resource use. DESIGN: Cross-sectional retrospective study. SETTING: Nonprofit academic medical center with campuses and multiple satellite offices in Ohio and Florida. PARTICIPANTS: Individuals aged 55 and older who visited UCCs between August 2014 and March 2015 (N = 9,445; average age 63...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29232032/erosive-pustular-dermatosis-of-the-scalp-reappraisal-of-an-underrecognized-entity
#7
REVIEW
Michael Wilk, Bettina G Zelger, Undine Hauser, Reinhard Höpfl, Bernhard Zelger
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. A history of previous surgery at the same site - as observed in four of our patients - is common. Coronary artery disease, cerebrovascular insult, arterial hypertension, diabetes mellitus, and severe cases of cancer were frequent comorbidities...
December 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29225000/-validity-of-the-abdominal-ecography-in-primary-care-for-detection-of-aorta-abdominal-aneurism-in-male-between-65-and-75-years
#8
Laura Bravo-Merino, Noelia González-Lozano, Ruth Maroto-Salmón, Gloria Meijide-Santos, Patricio Suárez-Gil, Ana Fañanás-Mastral
OBJECTIVE: To determine the usefulness of ultrasound examination in Primary Care (PC) for the detection of abdominal aortic aneurysm (AAA) in male patients from 65-75 years old, as well as the consistency between observers on the diagnosis between general practitioners and the reference specialty in this area, Vascular Surgery. To estimate the prevalence of AAA in that population and its association with risk factors. DESIGN: Cross-sectional descriptive study. LOCATION: Healthcare Centres of Coto and Calzada II (Gijón, Spain)...
December 7, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29220869/non-obese-fatty-liver-disease-is-associated-with-lacunar-infarct
#9
Min-Sun Kwak, Kyung Won Kim, Hyobin Seo, Goh-Eun Chung, Jeong Yoon Yim, Donghee Kim
BACKGROUND/AIMS: Lacunar infarct, a small subcortical ischemic lesion, is a known risk factor for future cognitive impairment, dementia, and stroke. We evaluated the relationship between fatty liver disease(FLD) and lacunar infarct in a healthy general population. METHODS: Subjects who underwent brain magnetic resonance imaging(MRI) and abdominal ultrasonography(US) during health check-ups from 2007-2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis, or cerebral small vessel disease were excluded...
December 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29217002/the-delta-2-registry-a-multicenter-registry-evaluating-percutaneous-coronary-intervention-with-new-generation-drug-eluting-stents-in-patients-with-obstructive-left-main-coronary-artery-disease
#10
Alaide Chieffo, Akihito Tanaka, Gennaro Giustino, Ieva Briede, Fadi J Sawaya, Joost Daemen, Hiroyoshi Kawamoto, Emanuele Meliga, Fabrizio D'Ascenzo, Enrico Cerrato, Giulio G Stefanini, Davide Capodanno, Andrea Mangiameli, Christian Templin, Andrejs Erglis, Marie Claude Morice, Roxana Mehran, Nicolas M Van Mieghem, Sunao Nakamura, Mauro De Benedictis, Marco Pavani, Ferdinando Varbella, Marco Pisaniello, Samin K Sharma, Corrado Tamburino, Didier Tchetche, Antonio Colombo
OBJECTIVES: The aim of this study was to evaluate clinical outcomes of unprotected left main coronary artery percutaneous coronary intervention (PCI) with new-generation drug-eluting stents in a "real world" population. BACKGROUND: PCI of the unprotected left main coronary artery is currently recommended as an alternative to coronary artery bypass grafting (CABG) in selected patients. METHODS: All consecutive patients with unprotected left main coronary artery stenosis treated by PCI with second-generation drug-eluting stents were analyzed in this international, all-comers, multicenter registry...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29213240/dipeptidyl-peptidase-4-inhibitors-use-and-relative-risk-of-ischemic-cerebrovascular-disease-in-type-2-diabetic-patients-in-a-case-control-study
#11
Shih-Wei Lai, Kuan-Fu Liao, Cheng-Li Lin, Hsien-Feng Lin
Background and Objectives: Limited research focuses on the risk of ischemic cerebrovascular disease associated with use of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) in patients with type 2 diabetes mellitus in Taiwan. This study aimed to investigate the association between DPP-4 inhibitors use and the first episode of ischemic cerebrovascular disease. Methods: We designed a case-control study using the database of the Taiwan National Health Insurance Program. There were 1999 type 2 diabetic subjects aged 20-84 years with the first episode of ischemic cerebrovascular disease from 2000 to 2013 as the cases, and 7996 sex- and age-matched, randomly selected type 2 diabetic subjects aged 20-84 years without any type of cerebrovascular diseases as the matched controls...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29209923/plasma-microparticles-in-alzheimer-s-disease-the-role-of-vascular-dysfunction
#12
Soheila Hosseinzadeh, Maryam Noroozian, Esmaeil Mortaz, Kazem Mousavizadeh
Cerebrovascular lesions, a potent stimulus for endothelial cell activation, trigger cognitive and degenerative changes and contribute to pathology of Alzheimer's disease (AD). Circulating microparticles (MPs) are actively involved in the pathogenesis of AD and cerebrovascular diseases, which share common vascular risk factors. We examined the plasma changes of endothelial MPs (EMPs) and platelet MPs (PMPs) in AD patients with vascular risk factors. The plasma Annexin V+ CD 41a- CD144+ EMPs and Annexin V+ CD41a+ CD144- PMPs of 37 patients with AD, with or without vascular risk factors (hypertension, diabetes, dyslipidemia, stroke, coronary artery disease, and smoking), and 10 age-matched controls were quantified by flow cytometry...
December 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29209102/the-incidence-of-depression-among-the-population-of-central-kazakhstan-and-its-relationship-with-sociodemographic-characteristics
#13
L Turgunova, Ye Laryushina, A Turmukhambetova, B Koichubekov, M Sorokina, I Korshukov
It has been established that the presence of depression is accompanied by an increased risk of morbidity and mortality in cerebrovascular and cardiovascular diseases and diabetes. The aim of this research was to estimate depressive symptom prevalence among the population in Central Kazakhstan and to define the relationship with social-demographic and behavioral factors. 1820 respondents of the population of Central Kazakhstan, aged 25 to 65, were performed. Participants included 777 urban and 1043 rural residents...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/29203738/mathematical-model-of-diabetic-encephalopathy
#14
Alla A Popruha, Lyudmyla E Bobyreva, Larisa A Samarchenko, Tatyana E Mykhaylychenko
INTRODUCTION: Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular disorders. The risk of stroke is 3-4 times higher in this population. In 10% of cases of vascular accidents in diabetic patients leads to fatal. The mortality rate for ischemic stroke is undergoing 50-60% and 70-95% of hemorrhagic form. It is known that diabetes increases the course of acute disorders of cerebral circulation. At the same time, there are data that about 415 million of the inhabitants of the planet suffer from diabetes, in 95% of cases they have type 2 diabetes, which is the second risk factor for the development of ischemic stroke after an arterial hypertension...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29202645/influence-of-specific-comorbidities-on-survival-after-early-stage-breast-cancer
#15
Marianne Ewertz, Lotte Holm Land, Susanne Oksbjerg Dalton, Deirdre Cronin-Fenton, Maj-Britt Jensen
BACKGROUND: While comorbidity indices are useful for describing trends in survival, information on specific comorbidities is needed for the clinician advising the individual breast cancer patient on her treatment. Here we present an analysis of overall survival, breast cancer-specific mortality, and effect of medical adjuvant treatment among breast cancer patients suffering from 12 major comorbidities compared with breast cancer patients without comorbidities. MATERIAL AND METHODS: The study population was identified from the Danish Breast Cancer Cooperative Group and included 59,673 women without prior cancer diagnosed with early-stage breast cancer in Denmark from 1990 to 2008 with an estimated median potential follow-up of 14 years and 10 months...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29199410/non-alcoholic-fatty-liver-disease-the-emerging-burden-in-cardiometabolic-and-renal-diseases
#16
REVIEW
Eugene Han, Yong Ho Lee
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes...
November 17, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29190572/increased-prevalence-and-risk-of-anxiety-disorders-in-adults-with-tinnitus-a-population-based-study-in-taiwan
#17
Ching-En Lin, Li-Fen Chen, Po-Han Chou, Chi-Hsiang Chung
OBJECTIVE: Tinnitus is a common disorder that may cause psychological distress and anxiety. The aim of this study was to investigate the association between anxiety disorders (ADs) and tinnitus in a large population. METHOD: We conducted a cross-sectional study using the National Health Insurance Research Database in Taiwan. Study subjects included 14,772 patients with tinnitus and 709,963 people in the general population who sought treatment in 2005. Distributions in ADs, age, sex, and medical comorbidities were compared between groups using chi-squared tests...
November 16, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29188858/modest-overweight-and-healthy-dietary-habits-reduce-risk-of-dementia-a-nationwide-survey-in-taiwan
#18
C-Y Lee, Y Sun, H-J Lee, T-F Chen, P-N Wang, K-N Lin, L-Y Tang, C-C Lin, M-J Chiu
BACKGROUND: Evidence of the associations of dietary habits and body mass index with dementia is inconsistent and limited in East Asian countries. OBJECTIVE: We aim to explore the associations of dietary habits and body mass index with the odds of dementia. DESIGN: Cross-sectional observational study. SETTING: A nationwide, population-based, door-to-door, in-person survey. PARTICIPANTS: Selected by computerized random sampling from all 19 counties in Taiwan...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186300/un-sweetening-the-heart-possible-pleiotropic-effects-of-sglt2-inhibitors-on-cardio-and-cerebrovascular-alterations-in-resistant-hypertensive-subjects
#19
Mariana R Pioli, Alessandra M V Ritter, Rodrigo Modolo
Resistant hypertension is a multifactorial disease associated with several target organ damage, such as microalbuminuria, left ventricular hypertrophy and arterial stiffness. These subjects have high cardiovascular complications, especially when associated with diabetes condition. SGLT-2 inhibitors represent a new class of oral antidiabetic drugs that have shown positive effects in diabetics and even hypertensives subjects. Several studies demonstrated positive outcomes related to blood pressure levels, body weight and glycemic control...
November 23, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29180133/cognitive-neurohistological-and-mortality-outcomes-following-the-four-vessel-occlusion-internal-carotid-artery-model-of-chronic-cerebral-hypoperfusion-the-impact-of-diabetes-and-aging
#20
Amanda Nunes Santiago, Emilene Dias Fiuza Ferreira, Rúbia M Weffort de Oliveira, Humberto Milani
Chronic cerebral hypoperfusion (CCH) may be involved in the etiology of aging-related dementias, and several risk factors contribute to their development and/or aggravation. We previously reported on the development of the 4-VO/ICA model of CCH, and the impact of hypertension on the cognitive and histological outcomes of CCH. Here, we advanced those studies by investigating how 4-VO/ICA alone or in combination with diabetes affects survival, body weight and cognitive performance in both young and middle-aged rats...
November 24, 2017: Behavioural Brain Research
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