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Diabetic cerebrovascular disease

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https://www.readbyqxmd.com/read/29432676/genistein-a-dual-inhibitor-of-both-a%C3%AE-and-hiapp-peptides
#1
Baiping Ren, Yonglan Liu, Yanxian Zhang, Yongqing Cai, Xiong Gong, Yung Chang, Lijian Xu, Jie Zheng
Abnormal misfolding and aggregation of amyloid peptides into amyloid fibrils are a common and critical pathological event in many neurodegenerative diseases. Most of inhibitors or drugs have been developed to prevent amyloid aggregation of a specific peptide, exhibiting sequence-dependent inhibition mechanisms. It is more challenging to develop or discover inhibitors capable of preventing the aggregation of two or more different amyloid peptides. Genistein, a major phytoestrogen in soybean, has been widely used as anti-inflammation and cerebrovascular drugs due to their anti-oxidation and anti-acetylcholinesterase effects...
February 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29419786/disease-and-economic-burden-of-hospitalizations-attributable-to-diabetes-mellitus-and-its-complications-a-nationwide-study-in-brazil
#2
Michelle Quarti Machado Rosa, Roger Dos Santos Rosa, Marcelo G Correia, Denizar V Araujo, Luciana R Bahia, Cristiana M Toscano
Diabetes is associated with a significant burden globally. The costs of diabetes-related hospitalizations are unknown in most developing countries. The aim of this study was to estimate the total number and economic burden of hospitalizations attributable to diabetes mellitus (DM) and its complications in adults from the perspective of the Brazilian Public Health System in 2014. Data sources included the National Health Survey (NHS) and National database of Hospitalizations (SIH). We considered diabetes, its microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular complications (coronary heart disease, cerebrovascular disease, and peripheral arterial disease), respiratory and urinary tract infections, as well as selected cancers...
February 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29412119/sodium-glucose-cotransporter-2-inhibitors-and-ischemic-stroke
#3
Dimitrios Milonas, Konstantinos Tziomalos
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with substantially increased risk for cardiovascular events, including ischemic stroke. In turn, ischemic stroke represents a leading cause of mortality and long-term disability worldwide. The newest class of glucose-lowering agents is sodium-glucose cotransporter 2 (SGLT-2) inhibitors, which act through inhibition of glucose reabsorption in the kidney, resulting in glucose excretion without stimulating insulin release. Accumulating data suggests that these agents improve multiple risk factors for ischemic stroke except their glucose-lowering effect...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29410188/blunted-cerebral-oxygenation-during-exercise-in-women-with-gestational-diabetes-mellitus-associations-with-macrovascular-function-and-cardiovascular-risk-factors
#4
Evangelia Kintiraki, Konstantina Dipla, Areti Triantafyllou, Nikolaos Koletsos, Iris Grigoriadou, Pavlos Poulakos, Vasileios Sachpekidis, Ioannis S Vrabas, Andreas Zafeiridis, Eleni Bili, Stella Douma, Dimitrios G Goulis
AIM / HYPOTHESIS: This cross-sectional, observational, controlled study examined cerebral oxygenation during exercise, an index of cerebrovascular function and cortical activation, in pregnancies complicated by gestational diabetes mellitus (GDM) and unaffected pregnancies. The association of cerebral oxygenation with macrovascular and cardiovascular function indices was also evaluated. MATERIAL AND METHODS: Vascular function and structure [aortic pulse-wave-velocity (PWV), augmentation index (AI), carotid intima-media thickness], as well as 24-h ambulatory blood pressure (BP) were assessed in women with GDM (n = 21) and uncomplicated pregnancies (n = 16), at 26-32 gestational weeks...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29397139/management-of-antiplatelet-therapy-in-patients-with-coronary-stents-undergoing-noncardiac-surgery-association-with-adverse-events
#5
A Rodriguez, N Guilera, A Mases, P Sierra, J C Oliva, C Colilles
BACKGROUND: Perioperative discontinuation of antiplatelet therapy (APT) in patients with coronary stents has been associated with major adverse cardiac events. Our aim was to analyse the perioperative management of APT in such patients and its relationship to the incidence of major adverse cardiac and cerebrovascular events (MACCE) and major bleeding events (MBE) in noncardiac surgery. METHODS: We completed a prospective multicentre observational study of patients with coronary stents undergoing noncardiac surgery in 11 hospitals in Spain...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29395954/perioperative-and-long-term-outcomes-after-radical-cystectomy-in-hemodialysis-patients
#6
Scott C Johnson, Zachary L Smith, Shay Golan, Joseph F Rodriguez, Shane M Pearce, Norm D Smith, Gary D Steinberg
PURPOSE: Patients on hemodialysis have an increased risk of developing advanced stage bladder cancer. They also have a significant risk of noncancer-related mortality. Radical cystectomy (RC) is the standard of care for nonmetastatic muscle-invasive bladder cancer, however little is known regarding outcomes in this population. MATERIALS AND METHODS: The United States Renal Disease System database was used to identify all patients on hemodialysis who underwent RC for bladder cancer in the United States between 1984 and 2013...
January 21, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29380913/vascular-dementia-clinicopathologic-and-genetic-considerations
#7
Harry V Vinters, Chris Zarow, Ewa Borys, Jeffrey D Whitman, Spencer Tung, William G Ellis, Ling Zheng, Helena C Chui
The incidence and severity of cerebrovascular disease (CVD) increase with advancing age, as does the risk of developing Alzheimer disease (AD). Not surprisingly, heterogeneous forms of CVD may coexist with AD changes in the 'aging brain'. These include angiopathies (affecting both large and small arteries) that result from 'classical' risk factors (hypertension, smoking, diabetes) and others (cerebral amyloid angiopathy) that are biochemically closely linked to AD. The morphologic consequences of these various vascular diseases are infarcts and/or haemorrhages of varying sizes within the brain, which lead to neurocognitive decline that may mimic AD-though the vascular abnormalities are usually detectable by neuroimaging...
January 30, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29374607/incidence-comorbidities-and-mortality-in-idiopathic-normal-pressure-hydrocephalus
#8
Okko T Pyykkö, Ossi Nerg, Hanna-Mari Niskasaari, Timo Niskasaari, Anne M Koivisto, Mikko Hiltunen, Jussi Pihlajamäki, Tuomas Rauramaa, Maria Kojoukhova, Irina Alafuzoff, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen
OBJECT: To investigate incidence, comorbidities, mortality, and causes of death in idiopathic normal pressure hydrocephalus (iNPH). METHODS: A cohort of 536 patients with possible NPH from a defined population with a median follow-up time of 5.1 years (range 0.04-19.9) was included in the study. Patients were evaluated by brain imaging and intraventricular pressure monitoring with a brain biopsy immunostained against amyloid-β and hyperphosphorylated tau. Hospital records were reviewed for vascular diseases and type 2 diabetes mellitus (T2DM)...
January 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29373707/cardiovascular-and-cerebrovascular-comorbidities-of-juvenile-dermatomyositis-in-us-children-an-analysis-of-the-national-inpatient-sample
#9
Jonathan I Silverberg, Lauren Kwa, Michael C Kwa, Anne E Laumann, Kaveh Ardalan
Objective: JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods: Data from the 2002-12 National Inpatient Sample was analysed, including ∼20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations)...
January 24, 2018: Rheumatology
https://www.readbyqxmd.com/read/29372939/can-statins-diminish-depression
#10
Devina Singh, Steven Lippmann
Depression is a common malady associated with numerous chronic medical conditions such as coronary artery disease, hypertension, and diabetes. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Statin medications also reduce inflammation. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression...
January 25, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29368891/-characterization-of-stroke-patients-attended-at-imss-hospitals-in-mexico-city
#11
Laura Del Pilar Torres-Arreola, Adriana Abigail Valenzuela-Flores, Juan Pablo Villa-Barragán
BACKGROUND: Cerebrovascular disease (CD) is considered a problem of huge social, economic and public health implications worldwide in adults and elderly. In Mexico, the information concerning the provision of services to people and their characteristics is limited. The objective is to describe the characteristics of patients with CV who attended the hospitals of the Instituto Mexicano del Seguro Social (IMSS) in Mexico City. METHODS: It was carried out a cohort study of patients with ischemic or hemorrhagic CD who arrived to IMSS...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29361829/barriers-to-hospice-care-in-trauma-patients-the-disparities-in-end-of-life-care
#12
Krista L Haines, Hee Soo Jung, Tiffany Zens, Scott Turner, Charles Warner-Hillard, Suresh Agarwal
INTRODUCTION: End-of-life and palliative care are important aspects of trauma care and are not well defined. This analysis evaluates the racial and socioeconomic disparities in terms of utilization of hospice services for critically ill trauma patients. METHODS: Trauma patients ≥15 years old from 2012 to 2015 were queried from the National Trauma Databank. Chi-square and multivariate logistic regression analyses for disposition to hospice were performed after controlling for age, gender, comorbidities, injury severity, insurance, race, and ethnicity...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29361126/changes-in-co-morbidity-pattern-in-patients-starting-renal-replacement-therapy-in-europe-data-from-the-era-edta-registry
#13
Maria L Ceretta, Marlies Noordzij, Rosario Luxardo, Johan De Meester, Jose M Abad Diez, Patrik Finne, James G Heaf, Cécile Couchoud, Reinhard Kramar, Frederic Collart, Aleix Cases, Runolfur Palsson, Anna V Reisæter, Helena Rydell, Ziad A Massy, Kitty J Jager, Anneke Kramer
Background: Patients starting renal replacement therapy (RRT) for end-stage renal disease often present with one or more co-morbidities. This study explored the prevalence of co-morbidities in patients who started RRT in Europe during the period from 2005 to 2014. Methods: Using data from patients aged 20 years or older from all 11 national or regional registries providing co-morbidity data to the European Renal Association - European Dialysis and Transplant Association Registry, we examined the prevalence of the following co-morbidities: diabetes mellitus (DM) (primary renal disease and/or co-morbidity), ischaemic heart disease (IHD), congestive heart failure (CHF), peripheral vascular disease (PVD), cerebrovascular disease (CVD) and malignancy...
January 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29360850/a-prospective-study-of-frequency-of-eating-restaurant-prepared-meals-and-subsequent-9-year-risk-of-all-cause-and-cardiometabolic-mortality-in-us-adults
#14
Ashima K Kant, Barry I Graubard
Restaurant prepared foods are known to be energy-dense and high in fat and sodium, but lower in protective nutrients. There is evidence of higher risk of adiposity, type II diabetes, and heart disease in frequent consumers of restaurant meals. However, the risk of mortality as a long-term health consequence of frequent consumption of restaurant meals has not been examined. We examined the prospective risk of all-cause and coronary heart disease, cerebrovascular disease and diabetes (cardiometabolic) mortality in relation to frequency of eating restaurant prepared meals in a national cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29352760/endothelial-function-estimated-by-digital-reactive-hyperemia-in-patients-with-atherosclerotic-risk-factors-or-coronary-artery-disease
#15
Jeehoon Kang, Hack-Lyoung Kim, Jae-Bin Seo, Jin-Yong Lee, Min-Kyong Moon, Woo-Young Chung
Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digital Reactive Hyperemia Index (RHI) in an actual population with multiple atherosclerotic risk factors or coronary artery disease (CAD). A total of 417 patients from the Seoul National University Boramae Medical Center RHI registry were enrolled in this study...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29350512/electronic-health-record-problem-lists-accurate-enough-for-risk-adjustment
#16
Timothy J Daskivich, Garen Abedi, Sherrie H Kaplan, Douglas Skarecky, Thomas Ahlering, Brennan Spiegel, Mark S Litwin, Sheldon Greenfield
OBJECTIVES: To determine whether comorbidity information derived from electronic health record (EHR) problem lists is accurate. STUDY DESIGN: Retrospective cohort study of 1596 men diagnosed with prostate cancer between 1998 and 2004 at 2 Southern California Veterans Affairs Medical Centers with long-term follow-up. METHODS: We compared EHR problem list-based comorbidity assessment with manual review of EHR free-text notes in terms of sensitivity and specificity for identification of major comorbidities and Charlson Comorbidity Index (CCI) scores...
January 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29344329/major-adverse-cardiovascular-event-reduction-with-glp-1-and-sglt2-agents-evidence-and-clinical-potential
#17
REVIEW
Michael E Røder
Treatment of patients with type 2 diabetes is directed against treating symptoms of hyperglycemia, minimizing the risk of hypoglycemia, and the risk of microvascular and macrovascular complications. The majority of patients with type 2 diabetes die from cardiovascular or cerebrovascular disease. Future therapies should therefore focus on reducing cardiovascular morbidity in this high-risk population. Glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are two drug classes with proven antihyperglycemic effect in type 2 diabetes...
January 2018: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29340912/predictors-of-hypoglycemia-in-hospitalized-patients-with-diabetes-mellitus
#18
Amit Akirov, Oren Amitai, Hiba Masri-Iraqi, Talia Diker-Cohen, Tzipora Shochat, Yoav Eizenberg, Ilan Shimon
Hypoglycemia is common among hospitalized patients with diabetes mellitus (DM), and is associated with increased morbidity and mortality. Identify pre-admission risk factors associated with in-hospital hypoglycemia. Historical prospectively collected data of adult DM patients hospitalized to medical wards between 2011 and 2013. Hypoglycemia and serious hypoglycemia were defined as at least one blood glucose measurement ≤ 70 and < 54 mg/dl, respectively, during hospitalization. The primary outcome was in-hospital hypoglycemia...
January 16, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29339691/rationale-design-and-methodology-of-the-evaluation-of-perceptions-knowledge-and-compliance-with-the-guidelines-in-real-life-practice-a-survey-on-the-under-treatment-of-hypercholesterolemia
#19
Volkan Doğan, Özcan Başaran, Bülent Özlek, Oğuzhan Çelik, Eda Özlek, Kadir Uğur Mert, İbrahim Rencüzoğulları, Gurbet Özge Mert, Marwa Mouline Doğan, Murat Biteker, Meral Kayıkçıoğlu
OBJECTIVE: A wide gap exists between dyslipidemia guidelines and their implementation in the real world, which is primarily attributed to physician and patient compliance. The aim of this study is to determine physician and patient adherence to dyslipidemia guidelines and various influential factors. METHODS: The Evaluation of Perceptions, Knowledge, and Compliance with the Guidelines in Real Life Practice: A Survey on the Under-treatment of Hypercholesterolemia (EPHESUS) trial (ClinicalTrials...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29337985/increased-risk-of-ischemic-heart-disease-hypertension-and-type-2-diabetes-in-women-with-previous-gestational-diabetes-mellitus-a-target-group-in-general-practice-for-preventive-interventions-a-population-based-cohort-study
#20
Barbara Daly, Konstantinos A Toulis, Neil Thomas, Krishna Gokhale, James Martin, Jonathan Webber, Deepi Keerthy, Kate Jolly, Ponnusamy Saravanan, Krishnarajah Nirantharakumar
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with developing type 2 diabetes, but very few studies have examined its effect on developing cardiovascular disease. METHODS AND FINDINGS: We conducted a retrospective cohort study utilizing a large primary care database in the United Kingdom. From 1 February 1990 to 15 May 2016, 9,118 women diagnosed with GDM were identified and randomly matched with 37,281 control women by age and timing of pregnancy (up to 3 months)...
January 2018: PLoS Medicine
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