Read by QxMD icon Read

Intrinsic atopic dermatitis

Takaaki Hiragun, Makiko Hiragun, Kaori Ishii, Takanobu Kan, Michihiro Hide
Sweat is an exacerbation factor in atopic dermatitis (AD) in all age groups. A body core temperature elevation with sweating triggers cholinergic urticaria (CholU). We recently reported that AD symptoms are improved by tannic acid-containing spray, which suppresses the basophil histamine release induced by semi-purified sweat antigen in vitro, and by showering, which removes antigens in sweat from the skin surface. Sweat contains small amount of proteins including proteases, protease inhibitors, and anti-microbial peptides...
March 9, 2017: Journal of Dermatological Science
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated TSLP production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. While TSLP and basophils have been implicated to promote food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites such as the gastrointestinal tract are poorly understood...
April 5, 2017: Journal of Allergy and Clinical Immunology
Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D Gruber, Burkhard Kleuser, Kateřina Vávrová, Sarah Hedtrich
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology. For example, thymic stromal lymphopoietin (TSLP) is highly expressed in lesional atopic skin and significantly contributes to the pathogenesis of AD by activating dendritic cells that then initiate downstream effects on, for example, T cells. However, little is known about the direct interplay between TSLP, filaggrin-deficient skin and other immune cells such as T lymphocytes...
April 4, 2017: Scientific Reports
Antonio Torrelo
BACKGROUND: The 4th generation topical corticosteroids (TCS) have demonstrated a most favorablerisk-benefit ratio. Methylprednisolone aceponate (MPA) is a non-halogenated corticosteroid with a methyl group at C6, which confers higher intrinsic activity. MPA is included in the group of potent TCS (category III/IV). METHODS: A literature review is carried out of the clinical efficacy, pharmacokinetics, and adverse effects of MPA, especially for the treatment of atopic dermatitis (AD)...
March 4, 2017: International Journal of Dermatology
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
Li-Ying Chen, Hsin-Fang Yang-Yen, Chun-Chou Tsai, Christina Li-Ping Thio, Hsiao-Li Chuang, Liang-Tung Yang, Li-Fen Shen, I-Wen Song, Kai-Ming Liu, Yen-Te Huang, Fu-Tong Liu, Ya-Jen Chang, Yuan-Tsong Chen, Jeffrey J Y Yen
Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder that results from intimate interactions between genetic predisposition, host environment, skin barrier defects, and immunological factors. However, a clear genetic roadmap leading to AD remains to be fully explored. From a genome-wide mutagenesis screen, deficiency of ZDHHC13, a palmitoylacyl transferase, has previously been associated with skin and multi-tissue inflammatory phenotypes. Here, we report that ZDHHC13 is required for skin barrier integrity and that deficiency of ZDHHC13 renders mice susceptible to environmental bacteria, resulting in persistent skin inflammation and an AD-like disease...
December 22, 2016: Journal of Investigative Dermatology
Ekaterina Avershina, Raul Cabrera Rubio, Krister Lundgård, Gaspar Perez Martinez, Maria Carmen Collado, Ola Storrø, Torbjørn Øien, Christian Kvikne Dotterud, Roar Johnsen, Knut Rudi
No abstract text is available yet for this article.
April 2017: Journal of Allergy and Clinical Immunology
Katja Bäsler, Johanna M Brandner
Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both. The specific processes, which mean the kind of cytokines and immune cells involved and the extent of the reaction, depend not only on the trigger but also on the predisposition of the individual. Tight junctions (TJs) in the skin have been shown to form a barrier in the granular cell layer of the epidermis...
January 2017: Pflügers Archiv: European Journal of Physiology
Thomas Marichal, Nicolas Gaudenzio, Sophie El Abbas, Riccardo Sibilano, Oliwia Zurek, Philipp Starkl, Laurent L Reber, Dimitri Pirottin, Jinah Kim, Pierre Chambon, Axel Roers, Nadine Antoine, Yuko Kawakami, Toshiaki Kawakami, Fabrice Bureau, See-Ying Tam, Mindy Tsai, Stephen J Galli
Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. RABGEF1-deficient keratinocytes exhibited aberrant activation of the intrinsic IL-1R/MYD88/NF-κB signaling pathway and MYD88-dependent abnormalities in expression of structural proteins that contribute to skin barrier function...
December 1, 2016: Journal of Clinical Investigation
M Fujimura, Y Nakatsuji, H Ishimaru
In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups...
September 1, 2016: Polish Journal of Veterinary Sciences
Chih-Hung Lee, Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Li-Fang Wang
BACKGROUND: Epicutaneous immunization with allergens is an important sensitization route for atopic dermatitis. We recently showed in addition to the Th2 response following single epicutaneous immunization, a remarkable Th1 response is induced in B6 mice, but not in BALB/c mice, mimicking the immune response to allergens in human non-atopics and atopics. OBJECTIVE: We investigated the underlying mechanisms driving this differential Th1 response between BALB/c and B6 mice...
December 2016: Journal of Dermatological Science
Jung Soo Kim, Jinyoung Choi, Hyung-Jin Hahn, Young-Bok Lee, Dong-Soo Yu, Jin-Wou Kim
The macrophage migration inhibitory factor (MIF) gene is located on human chromosome 22q11.2 and is linked to atopic phenotypes. Plasma MIF and log [total IgE] levels are significantly elevated in atopic dermatitis (AD) patients. The aim of this study was to evaluate the relationship between two MIF polymorphisms, -173 G to C and -794 CATT5-8, and total plasma IgE levels in AD patients in Korea. We performed PCR-RFLP analysis in 178 AD patients and 80 control subjects to determine whether MIF SNPs are associated with susceptibility to AD...
2016: PloS One
Anna Rosińska-Więckowicz, Magdalena Czarnecka-Operacz, Zygmunt Adamski
INTRODUCTION: It has been suggested that soluble immune receptors (SIRs) such as sCD25 and sCD30 may serve as potential biomarkers in evaluation of atopic dermatitis (AD). Previous studies clearly indicated that serum levels of interleukin (IL)-13 and total IgE (tIgE) might be potentially useful in the evaluation of patents with AD. AIM: To evaluate whether serum levels of sCD25 and sCD30 are suitable biomarkers of AD. Moreover, we have decided to estimate the usefulness of tIgE and IL-13 serum level determination in the evaluated population...
June 2016: Postȩpy Dermatologii i Alergologii
Ružica Jurakić Tončić, Branka Marinović
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great variability of clinical presentation, and diagnosis can sometimes be challenging and difficult. Diagnosis mostly relies on clinical features and laboratory tests, but morphology alone cannot reliably establish the diagnosis, so the spectrum of features associated with AD must be considered...
June 2016: Acta Dermatovenerologica Croatica: ADC
Tatyana Vinnik, Michael Kirby, Maryia Bairachnaya, Igor Koman, Tatyana Tarkina, Sadykova Gulnaz, Gulshara Abildinova, Gulnara Batpenova, Albert Pinhasov
OBJECTIVES: To examine the effect of seasonality and rs6265 genotype on depression outcome and BDNF level with dermatitis patients from onset through remission. METHODS: Atopic dermatitis (AD:56) and psoriasis (PS:33) patients and healthy controls (HC:49) were recruited over the 2014 calendar year. Patients were subdivided by IgE sensitivity (AD only), season and rs6265 genotype. Assessments were performed at onset and week 10 (Hamilton Depression Rating Scale [HAM-D], SCORAD/PASI, IgE, BDNF)...
July 13, 2016: World Journal of Biological Psychiatry
Antonio Chuh, Vijay Zawar, Albert Lee, Gabriel Sciallis
OBJECTIVES: To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. METHODS: The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls...
September 2016: Pediatric Dermatology
X Dou, J Kim, C Y Ni, Y Shao, J Zhang
BACKGROUND: The atopy patch test (APT) has been defined as an important tool in the diagnosis of cutaneous hypersensitivity caused by house dust mites in atopic dermatitis (AD). OBJECTIVE: The aim of this study was to evaluate the diagnostic value of the APT to mite allergens by comparing its positive results with those of the skin prick test (SPT) and serum specific IgE test in Chinese AD patients. METHODS: The APT, SPT and serum specific IgE test with Dermatophagoiodes pteronyssinus and Dermatophagoides farina were performed on a total of 120 patients with atopic dermatitis...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Maria Magdalena Roth, Patricia Cristodor, George Kroumpouzos
Prurigo (PP) and pruritic folliculitis of pregnancy (PFP) are poorly characterized entities. Traditionally classified under specific dermatoses of pregnancy, they were reclassified under a new umbrella entity, atopic eruption of pregnancy (AEP), which also includes atopic dermatitis (AD) that can worsen or present for the first time in pregnancy. Still, several aspects of AEP have not been adequately elucidated. It needs to be clarified whether it is the intrinsic ("nonallergic" or "atopiform dermatitis") or extrinsic (immunoglobulin E-associated) AD that is affected by pregnancy...
May 2016: Clinics in Dermatology
U Blume-Peytavi, J Tan, D Tennstedt, F Boralevi, G Fabbrocini, A Torrelo, R Soares-Oliveira, M Haftek, A B Rossi, M D Thouvenin, J Mangold, M F Galliano, H Hernandez-Pigeon, M F Aries, C Rouvrais, S Bessou-Touya, H Duplan, N Castex-Rizzi, V Mengeaud, P J Ferret, E Clouet, M Saint Aroman, C Carrasco, C Coutanceau, B Guiraud, S Boyal, A Herman, H Delga, K Biniek, R Dauskardt
Within their first days of life, newborns' skin undergoes various adaptation processes needed to accommodate the transition from the wet uterine environment to the dry atmosphere. The skin of newborns and infants is considered as a physiological fragile skin, a skin with lower resistance to aggressions. Fragile skin is divided into four categories up to its origin: physiological fragile skin (age, location), pathological fragile skin (acute and chronic), circumstantial fragile skin (due to environmental extrinsic factors or intrinsic factors such as stress) and iatrogenic fragile skin...
May 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Britta C Martel, Thomas Litman, Andreas Hald, Hanne Norsgaard, Paola Lovato, Beatrice Dyring-Andersen, Lone Skov, Kristian Thestrup-Pedersen, Søren Skov, Kresten Skak, Lars K Poulsen
Atopic dermatitis (AD) is a common inflammatory skin disease with underlying defects in epidermal function and immune responses. In this study, we used microarray analysis to investigate differences in gene expression in lesional skin from patients with mild extrinsic or intrinsic AD compared to skin from healthy controls and from lesional psoriasis skin. The primary aim was to identify differentially expressed genes involved in skin barrier formation and inflammation, and to compare our results with those reported for patients with moderate and severe AD...
June 2016: Experimental Dermatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"