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Intrinsic atopic dermatitis

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https://www.readbyqxmd.com/read/28869867/atopic-dermatitis-and-psoriasis-two-different-immune-diseases-or-one-spectrum
#1
REVIEW
Emma Guttman-Yassky, James G Krueger
Psoriasis and atopic dermatitis (AD) are common T-cell mediated inflammatory diseases of the skin that can be treated by specific cytokine antagonists or more broad immunosuppressive drugs. The diseases are similar in that epidermal keratinocytes respond to T-cell derived cytokines by altering growth and differentiation responses, accounting for major parts of the overall disease phenotype. When studied across European-American populations, psoriasis and AD display differing T-cell polarity and different arrays of cytokines...
September 1, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28709570/systemic-therapies-in-atopic-dermatitis-the-pipeline
#2
Yael Renert-Yuval, Emma Guttman-Yassky
Atopic dermatitis (AD), the most prevalent inflammatory skin disease, is characterized by robust T-cell activation. The disease has several subtypes, all having a common T helper type 2 (Th2)/Th22 polarization, but it also displays differential immune skewing, such as increased Th17/interleukin 23 skewing in the skin of intrinsic, Asian, and early pediatric AD patients. Current systemic treatments for moderate to severe AD are largely unsatisfactory, associated with significant adverse effects and low compliance...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28653395/parp14-limits-severity-of-allergic-skin-disease
#3
Purna Krishnamurthy, Sonia Da-Silva-Arnold, Matthew J Turner, Jeffrey B Travers, Mark H Kaplan
Poly-ADP ribose polymerase-14 (PARP14 or ARTD8) was initially identified as a transcriptional co-activator for Stat6, where the presence of IL-4 and activated Stat6 induces the enzymatic activity of PARP14 that promotes Th2 differentiation and allergic airway disease. To further our understanding of PARP14 in allergic disease, we studied the function of PARP14 in allergic inflammation of skin using mice that express constitutively active Stat6 in T cells (Stat6VT) and develop spontaneous inflammation of the skin...
June 27, 2017: Immunology
https://www.readbyqxmd.com/read/28416076/sweat-allergy-extrinsic-or-intrinsic
#4
REVIEW
Takaaki Hiragun, Makiko Hiragun, Kaori Ishii, Takanobu Kan, Michihiro Hide
Sweat is an exacerbation factor in atopic dermatitis (AD) in all age groups. A body core temperature elevation with sweating triggers cholinergic urticaria (CholU). We recently reported that AD symptoms are improved by tannic acid-containing spray, which suppresses the basophil histamine release induced by semi-purified sweat antigen in vitro, and by showering, which removes antigens in sweat from the skin surface. Sweat contains small amount of proteins including proteases, protease inhibitors, and anti-microbial peptides...
July 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28390860/basophil-derived-il-4-promotes-epicutaneous-antigen-sensitization-concomitant-with-the-development-of-food-allergy
#5
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated thymic stromal lymphopoietin (TSLP) production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. Although TSLP and basophils have been implicated in promotion of food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites, such as the gastrointestinal tract, are poorly understood...
April 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28377574/tslp-is-a-direct-trigger-for-t-cell-migration-in-filaggrin-deficient-skin-equivalents
#6
Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D Gruber, Burkhard Kleuser, Kateřina Vávrová, Sarah Hedtrich
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology. For example, thymic stromal lymphopoietin (TSLP) is highly expressed in lesional atopic skin and significantly contributes to the pathogenesis of AD by activating dendritic cells that then initiate downstream effects on, for example, T cells. However, little is known about the direct interplay between TSLP, filaggrin-deficient skin and other immune cells such as T lymphocytes...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28258632/methylprednisolone-aceponate-for-atopic-dermatitis
#7
Antonio Torrelo
BACKGROUND: The 4th generation topical corticosteroids (TCS) have demonstrated a most favorablerisk-benefit ratio. Methylprednisolone aceponate (MPA) is a non-halogenated corticosteroid with a methyl group at C6, which confers higher intrinsic activity. MPA is included in the group of potent TCS (category III/IV). METHODS: A literature review is carried out of the clinical efficacy, pharmacokinetics, and adverse effects of MPA, especially for the treatment of atopic dermatitis (AD)...
March 4, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#8
L H Blom, B C Martel, L F Larsen, C V Hansen, M P Christensen, N Juel-Berg, T Litman, L K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T cells were short-term activated in the presence or absence of IL-4 and analyzed for expression of >300 cell-surface proteins...
July 2017: Allergy
https://www.readbyqxmd.com/read/28017833/protein-palmitoylation-by-zdhhc13-protects-skin-against-microbial-driven-dermatitis
#9
Li-Ying Chen, Hsin-Fang Yang-Yen, Chun-Chou Tsai, Christina Li-Ping Thio, Hsiao-Li Chuang, Liang-Tung Yang, Li-Fen Shen, I-Wen Song, Kai-Ming Liu, Yen-Te Huang, Fu-Tong Liu, Ya-Jen Chang, Yuan-Tsong Chen, Jeffrey J Y Yen
Atopic dermatitis is a complex chronic inflammatory skin disorder that results from intimate interactions among genetic predisposition, host environment, skin barrier defects, and immunological factors. However, a clear genetic roadmap leading to atopic dermatitis remains to be fully explored. From a genome-wide mutagenesis screen, deficiency of ZDHHC13, a palmitoylacyl transferase, has previously been associated with skin and multitissue inflammatory phenotypes. Here, we report that ZDHHC13 is required for skin barrier integrity and that deficiency of ZDHHC13 renders mice susceptible to environmental bacteria, resulting in persistent skin inflammation and an atopic dermatitis-like disease...
April 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27931973/effect-of-probiotics-in-prevention-of-atopic-dermatitis-is-dependent-on-the-intrinsic-microbiota-at-early-infancy
#10
Ekaterina Avershina, Raul Cabrera Rubio, Krister Lundgård, Gaspar Perez Martinez, Maria Carmen Collado, Ola Storrø, Torbjørn Øien, Christian Kvikne Dotterud, Roar Johnsen, Knut Rudi
No abstract text is available yet for this article.
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27853878/tight-junctions-in-skin-inflammation
#11
REVIEW
Katja Bäsler, Johanna M Brandner
Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both. The specific processes, which mean the kind of cytokines and immune cells involved and the extent of the reaction, depend not only on the trigger but also on the predisposition of the individual. Tight junctions (TJs) in the skin have been shown to form a barrier in the granular cell layer of the epidermis...
January 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27820702/guanine-nucleotide-exchange-factor-rabgef1-regulates-keratinocyte-intrinsic-signaling-to-maintain-skin-homeostasis
#12
Thomas Marichal, Nicolas Gaudenzio, Sophie El Abbas, Riccardo Sibilano, Oliwia Zurek, Philipp Starkl, Laurent L Reber, Dimitri Pirottin, Jinah Kim, Pierre Chambon, Axel Roers, Nadine Antoine, Yuko Kawakami, Toshiaki Kawakami, Fabrice Bureau, See-Ying Tam, Mindy Tsai, Stephen J Galli
Epidermal keratinocytes form a structural and immune barrier that is essential for skin homeostasis. However, the mechanisms that regulate epidermal barrier function are incompletely understood. Here we have found that keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. RABGEF1-deficient keratinocytes exhibited aberrant activation of the intrinsic IL-1R/MYD88/NF-κB signaling pathway and MYD88-dependent abnormalities in expression of structural proteins that contribute to skin barrier function...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27760033/cyclosporin-a-treatment-in-intrinsic-canine-atopic-dermatitis-atopic-like-dermatitis-open-trial-study
#13
M Fujimura, Y Nakatsuji, H Ishimaru
In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27756516/differential-activation-behavior-of-dermal-dendritic-cells-underlies-the-strain-specific-th1-responses-to-single-epicutaneous-immunization
#14
Chih-Hung Lee, Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Li-Fang Wang
BACKGROUND: Epicutaneous immunization with allergens is an important sensitization route for atopic dermatitis. We recently showed in addition to the Th2 response following single epicutaneous immunization, a remarkable Th1 response is induced in B6 mice, but not in BALB/c mice, mimicking the immune response to allergens in human non-atopics and atopics. OBJECTIVE: We investigated the underlying mechanisms driving this differential Th1 response between BALB/c and B6 mice...
December 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27598332/association-of-macrophage-migration-inhibitory-factor-polymorphisms-with-total-plasma-ige-levels-in-patients-with-atopic-dermatitis-in-korea
#15
Jung Soo Kim, Jinyoung Choi, Hyung-Jin Hahn, Young-Bok Lee, Dong-Soo Yu, Jin-Wou Kim
The macrophage migration inhibitory factor (MIF) gene is located on human chromosome 22q11.2 and is linked to atopic phenotypes. Plasma MIF and log [total IgE] levels are significantly elevated in atopic dermatitis (AD) patients. The aim of this study was to evaluate the relationship between two MIF polymorphisms, -173 G to C and -794 CATT5-8, and total plasma IgE levels in AD patients in Korea. We performed PCR-RFLP analysis in 178 AD patients and 80 control subjects to determine whether MIF SNPs are associated with susceptibility to AD...
2016: PloS One
https://www.readbyqxmd.com/read/27512357/selected-immunological-parameters-in-clinical-evaluation-of-patients-with-atopic-dermatitis
#16
Anna Rosińska-Więckowicz, Magdalena Czarnecka-Operacz, Zygmunt Adamski
INTRODUCTION: It has been suggested that soluble immune receptors (SIRs) such as sCD25 and sCD30 may serve as potential biomarkers in evaluation of atopic dermatitis (AD). Previous studies clearly indicated that serum levels of interleukin (IL)-13 and total IgE (tIgE) might be potentially useful in the evaluation of patents with AD. AIM: To evaluate whether serum levels of sCD25 and sCD30 are suitable biomarkers of AD. Moreover, we have decided to estimate the usefulness of tIgE and IL-13 serum level determination in the evaluated population...
June 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27477169/the-role-of-impaired-epidermal-barrier-function-in-atopic-dermatitis
#17
REVIEW
Ružica Jurakić Tončić, Branka Marinović
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great variability of clinical presentation, and diagnosis can sometimes be challenging and difficult. Diagnosis mostly relies on clinical features and laboratory tests, but morphology alone cannot reliably establish the diagnosis, so the spectrum of features associated with AD must be considered...
June 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27409526/seasonality-and-bdnf-polymorphism-influences-depression-outcome-in-patients-with-atopic-dermatitis-and-psoriasis
#18
Tatyana Vinnik, Michael Kirby, Maryia Bairachnaya, Igor Koman, Tatyana Tarkina, Gulnaz Sadykova, Gulshara Abildinova, Gulnara Batpenova, Albert Pinhasov
OBJECTIVES: To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission. METHODS: Atopic dermatitis (AD, 56) and psoriasis (PS, 33) patients and healthy controls (HC, 49) were recruited over the 2014 calendar year. Patients were subdivided by immunoglobulin E (IgE) sensitivity (AD only), season and rs6265 genotype. Assessments were performed at onset and week 10 (Hamilton Depression Rating Scale [HAM-D], SCORAD/PASI, IgE, BDNF)...
August 16, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27339179/is-gianotti-crosti-syndrome-associated-with-atopy-a-case-control-study-and-a-postulation-on-the-intrinsic-host-factors-in-gianotti-crosti-syndrome
#19
COMPARATIVE STUDY
Antonio Chuh, Vijay Zawar, Albert Lee, Gabriel Sciallis
OBJECTIVES: To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. METHODS: The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27329364/atopy-patch-test-with-house-dust-mite-in-chinese-patients-with-atopic-dermatitis
#20
X Dou, J Kim, C Y Ni, Y Shao, J Zhang
BACKGROUND: The atopy patch test (APT) has been defined as an important tool in the diagnosis of cutaneous hypersensitivity caused by house dust mites in atopic dermatitis (AD). OBJECTIVE: The aim of this study was to evaluate the diagnostic value of the APT to mite allergens by comparing its positive results with those of the skin prick test (SPT) and serum specific IgE test in Chinese AD patients. METHODS: The APT, SPT and serum specific IgE test with Dermatophagoiodes pteronyssinus and Dermatophagoides farina were performed on a total of 120 patients with atopic dermatitis...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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