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Intrinsic atopic dermatitis

M Fujimura, Y Nakatsuji, H Ishimaru
In this study, dogs were separated into two groups and treated with immunosuppressant (Cyclosporin A: CsA). The first group was the canine atopic dermatitis (CAD) group, which is similar to extrinsic atopic dermatitis (AD) in humans (treated with a CsA dose of 2.5-5.5 mg/kg, n=8), and the second group was the canine atopic-like dermatitis (ALD) group, which is similar to intrinsic AD in humans (treated with a CsA dose of 2.5-6.5 mg/kg, n=14). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (PRE) and after treatment (POST) to assess the effectiveness of CsA for the two groups...
September 1, 2016: Polish Journal of Veterinary Sciences
Chih-Hung Lee, Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Li-Fang Wang
BACKGROUND: Epicutaneous immunization with allergens is an important sensitization route for atopic dermatitis. We recently showed in addition to the Th2 response following single epicutaneous immunization, a remarkable Th1 response is induced in B6 mice, but not in BALB/c mice, mimicking the immune response to allergens in human non-atopics and atopics. OBJECTIVE: We investigated the underlying mechanisms driving this differential Th1 response between BALB/c and B6 mice...
October 3, 2016: Journal of Dermatological Science
Jung Soo Kim, Jinyoung Choi, Hyung-Jin Hahn, Young-Bok Lee, Dong-Soo Yu, Jin-Wou Kim
The macrophage migration inhibitory factor (MIF) gene is located on human chromosome 22q11.2 and is linked to atopic phenotypes. Plasma MIF and log [total IgE] levels are significantly elevated in atopic dermatitis (AD) patients. The aim of this study was to evaluate the relationship between two MIF polymorphisms, -173 G to C and -794 CATT5-8, and total plasma IgE levels in AD patients in Korea. We performed PCR-RFLP analysis in 178 AD patients and 80 control subjects to determine whether MIF SNPs are associated with susceptibility to AD...
2016: PloS One
Anna Rosińska-Więckowicz, Magdalena Czarnecka-Operacz, Zygmunt Adamski
INTRODUCTION: It has been suggested that soluble immune receptors (SIRs) such as sCD25 and sCD30 may serve as potential biomarkers in evaluation of atopic dermatitis (AD). Previous studies clearly indicated that serum levels of interleukin (IL)-13 and total IgE (tIgE) might be potentially useful in the evaluation of patents with AD. AIM: To evaluate whether serum levels of sCD25 and sCD30 are suitable biomarkers of AD. Moreover, we have decided to estimate the usefulness of tIgE and IL-13 serum level determination in the evaluated population...
June 2016: Postȩpy Dermatologii i Alergologii
Ružica Jurakić Tončić, Branka Marinović
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great variability of clinical presentation, and diagnosis can sometimes be challenging and difficult. Diagnosis mostly relies on clinical features and laboratory tests, but morphology alone cannot reliably establish the diagnosis, so the spectrum of features associated with AD must be considered...
June 2016: Acta Dermatovenerologica Croatica: ADC
Tatyana Vinnik, Michael Kirby, Maryia Bairachnaya, Igor Koman, Tatyana Tarkina, Sadykova Gulnaz, Gulshara Abildinova, Gulnara Batpenova, Albert Pinhasov
OBJECTIVES: To examine the effect of seasonality and rs6265 genotype on depression outcome and BDNF level with dermatitis patients from onset through remission. METHODS: Atopic dermatitis (AD:56) and psoriasis (PS:33) patients and healthy controls (HC:49) were recruited over the 2014 calendar year. Patients were subdivided by IgE sensitivity (AD only), season and rs6265 genotype. Assessments were performed at onset and week 10 (Hamilton Depression Rating Scale [HAM-D], SCORAD/PASI, IgE, BDNF)...
July 13, 2016: World Journal of Biological Psychiatry
Antonio Chuh, Vijay Zawar, Albert Lee, Gabriel Sciallis
OBJECTIVES: To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. METHODS: The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls...
September 2016: Pediatric Dermatology
X Dou, J Kim, C Y Ni, Y Shao, J Zhang
BACKGROUND: The atopy patch test (APT) has been defined as an important tool in the diagnosis of cutaneous hypersensitivity caused by house dust mites in atopic dermatitis (AD). OBJECTIVE: The aim of this study was to evaluate the diagnostic value of the APT to mite allergens by comparing its positive results with those of the skin prick test (SPT) and serum specific IgE test in Chinese AD patients. METHODS: The APT, SPT and serum specific IgE test with Dermatophagoiodes pteronyssinus and Dermatophagoides farina were performed on a total of 120 patients with atopic dermatitis...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Maria Magdalena Roth, Patricia Cristodor, George Kroumpouzos
Prurigo (PP) and pruritic folliculitis of pregnancy (PFP) are poorly characterized entities. Traditionally classified under specific dermatoses of pregnancy, they were reclassified under a new umbrella entity, atopic eruption of pregnancy (AEP), which also includes atopic dermatitis (AD) that can worsen or present for the first time in pregnancy. Still, several aspects of AEP have not been adequately elucidated. It needs to be clarified whether it is the intrinsic ("nonallergic" or "atopiform dermatitis") or extrinsic (immunoglobulin E-associated) AD that is affected by pregnancy...
May 2016: Clinics in Dermatology
U Blume-Peytavi, J Tan, D Tennstedt, F Boralevi, G Fabbrocini, A Torrelo, R Soares-Oliveira, M Haftek, A B Rossi, M D Thouvenin, J Mangold, M F Galliano, H Hernandez-Pigeon, M F Aries, C Rouvrais, S Bessou-Touya, H Duplan, N Castex-Rizzi, V Mengeaud, P J Ferret, E Clouet, M Saint Aroman, C Carrasco, C Coutanceau, B Guiraud, S Boyal, A Herman, H Delga, K Biniek, R Dauskardt
Within their first days of life, newborns' skin undergoes various adaptation processes needed to accommodate the transition from the wet uterine environment to the dry atmosphere. The skin of newborns and infants is considered as a physiological fragile skin, a skin with lower resistance to aggressions. Fragile skin is divided into four categories up to its origin: physiological fragile skin (age, location), pathological fragile skin (acute and chronic), circumstantial fragile skin (due to environmental extrinsic factors or intrinsic factors such as stress) and iatrogenic fragile skin...
May 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Britta C Martel, Thomas Litman, Andreas Hald, Hanne Norsgaard, Paola Lovato, Beatrice Dyring-Andersen, Lone Skov, Kristian Thestrup-Pedersen, Søren Skov, Kresten Skak, Lars K Poulsen
Atopic dermatitis (AD) is a common inflammatory skin disease with underlying defects in epidermal function and immune responses. In this study, we used microarray analysis to investigate differences in gene expression in lesional skin from patients with mild extrinsic or intrinsic AD compared to skin from healthy controls and from lesional psoriasis skin. The primary aim was to identify differentially expressed genes involved in skin barrier formation and inflammation, and to compare our results with those reported for patients with moderate and severe AD...
June 2016: Experimental Dermatology
Britta C Martel, Beatrice Dyring-Andersen, Lone Skov, Kristian Thestrup-Pedersen, Søren Skov, Kresten Skak, Lars K Poulsen
OBJECTIVES: To investigate differences in expression of surface markers, cytokine profiles, and presence of CD4(+)CD8(+) T cells in skin-derived T cell cultures from patients with extrinsic atopic dermatitis (AD), intrinsic AD, and psoriasis expanded in the presence of IL-2 and IL-4. MATERIAL: Skin biopsies from patients with extrinsic AD (n = 6), intrinsic AD (n = 9) and psoriasis (n = 9). METHODS: Skin-derived T cell cultures were analyzed for expression of six surface markers, 11 intracellular cytokines, and three T cell subtype signature transcription factors by flow cytometry, and secreted cytokines by multiplex...
April 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Hyun Soo Park, Noo Ri Hong, Tae Seok Ahn, Hyungwoo Kim, Myeong Ho Jung, Byung Joo Kim
BACKGROUND: The root bark of Dictamnus dasycarpus Turcz has traditionally been used in East Asia to treat skin diseases such as eczema, atopic dermatitis, and psoriasis. However, it has also been reported to exhibit an anti-proliferative effect on cancer cells. OBJECTIVE: To investigate the anti-cancer effects of a methanol extract of Dictamnus dasycarpus root bark (MEDD) on AGS cells (a human gastric adenocarcinoma cell-line). MATERIALS AND METHODS: An 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium assay, a caspase activity assay, cell cycle analysis, mitochondrial membrane potential (MMP) measurements, and western blotting were used to investigate the anti-cancer effects of MEDD on AGS cells...
October 2015: Pharmacognosy Magazine
Alexandra Y Kreins, Michael J Ciancanelli, Satoshi Okada, Xiao-Fei Kong, Noé Ramírez-Alejo, Sara Sebnem Kilic, Jamila El Baghdadi, Shigeaki Nonoyama, Seyed Alireza Mahdaviani, Fatima Ailal, Aziz Bousfiha, Davood Mansouri, Elma Nievas, Cindy S Ma, Geetha Rao, Andrea Bernasconi, Hye Sun Kuehn, Julie Niemela, Jennifer Stoddard, Paul Deveau, Aurelie Cobat, Safa El Azbaoui, Ayoub Sabri, Che Kang Lim, Mikael Sundin, Danielle T Avery, Rabih Halwani, Audrey V Grant, Bertrand Boisson, Dusan Bogunovic, Yuval Itan, Marcela Moncada-Velez, Ruben Martinez-Barricarte, Melanie Migaud, Caroline Deswarte, Laia Alsina, Daniel Kotlarz, Christoph Klein, Ingrid Muller-Fleckenstein, Bernhard Fleckenstein, Valerie Cormier-Daire, Stefan Rose-John, Capucine Picard, Lennart Hammarstrom, Anne Puel, Saleh Al-Muhsen, Laurent Abel, Damien Chaussabel, Sergio D Rosenzweig, Yoshiyuki Minegishi, Stuart G Tangye, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, and staphylococcal abscesses. We identified seven other TYK2-deficient patients from five families and four different ethnic groups. These patients were homozygous for one of five null mutations, different from that seen in P1. They displayed mycobacterial and/or viral infections, but no HIES...
September 21, 2015: Journal of Experimental Medicine
Yasaman Mansouri, Emma Guttman-Yassky
Atopic dermatitis (AD) is the most common inflammatory skin disease. Recent research findings have provided an insight into the complex pathogenic mechanisms involved in this disease. Despite a rising prevalence, effective and safe therapeutics for patients with moderate-to-severe AD are still lacking. Biomarkers of lesional, nonlesional skin, and blood have been developed for baseline as well as after treatment with broad and specific treatments (i.e., cyclosporine A and dupilumab). These biomarkers will help with the development of novel targeted therapeutics and assessment of disease reversal, with the promise of a more personalized treatment approach...
2015: Journal of Clinical Medicine
Chante Karimkhani, Jonathan I Silverberg, Robert P Dellavalle
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition characterized by eczematous lesions, i.e. ill-demarcated erythematous patches and plaques. AD is commonly associated with elevated immunoglobulin E (IgE) and atopic disorders, such as asthma, hay fever, and food allergies. Rackemann and Mallory were some of the first to distinguish between asthma based on the presence ("extrinsic") or absence ("intrinsic") of allergy. This distinction has subsequently been applied to AD based on the presence ("extrinsic") or absence ("intrinsic") of increased IgE and atopic disease...
June 2015: Dermatology Online Journal
Susanne Hradetzky, Thomas Werfel, Lennart M Rösner
The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent insights into the autoallergic inflammation in AD. Different mechanisms underlying the allergenicity of autoallergens are discussed at the moment: intrinsic functions modulating the immune system as well as molecular mimicry may influence the allergenic potential of these proteins...
2015: Allergo Journal International
Jung-Hyun Namkung, Eugene Kim, Yong-Doo Park, Geontae Park, Jun-Mo Yang
BACKGROUND: The histologic characteristics of atopic dermatitis (AD) include perivascular edema and dilated tortuous vessels in the papillary dermis. A single nucleotide polymorphism (SNP) of the fms-related tyrosine kinase 4 (FLT4) gene is associated with AD. OBJECTIVE: To investigate the associations between podoplanin (PDPN) gene SNPs and AD. METHODS: We genotyped 9 SNPs from 5 genes of 1,119 subjects (646 AD patients and 473 controls)...
June 2015: Annals of Dermatology
John R Lukens, Prajwal Gurung, Patrick J Shaw, Maggie J Barr, Md Hasan Zaki, Scott A Brown, Peter Vogel, Hongbo Chi, Thirumala-Devi Kanneganti
Missense mutations in the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are associated with periodic fever syndromes and atopic dermatitis in humans. Here, we have demonstrated a crucial role for NLRP12 in negatively regulating pathogenic T cell responses. Nlrp12(-/-) mice responded to antigen immunization with hyperinflammatory T cell responses. Furthermore, transfer of CD4(+)CD45RB(hi)Nlrp12(-/-) T cells into immunodeficient mice led to more severe colitis and atopic dermatitis...
April 21, 2015: Immunity
Tali Czarnowicki, James G Krueger, Emma Guttman-Yassky
Atopic dermatitis is the most common chronic inflammatory skin disease. Its pathogenesis combines barrier defects, immune dysregulation, and increased skin infections; however, the relative contribution of each of these components is yet to be determined. Uninvolved atopic dermatitis skin also displays broad immune and barrier abnormalities, which highlights a role for proactive treatment strategy. The residual disease genomic profile that accompanies clinical resolution provides further support for proactive treatment approaches...
July 2014: Journal of Allergy and Clinical Immunology in Practice
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