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Sense of Agency

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https://www.readbyqxmd.com/read/28440706/agency-and-communion-in-people-with-alzheimer-s-disease-as-described-by-themselves-and-their-spousal-carers
#1
Ragnhild Hedman, Astrid Norberg, Ingrid Hellström
Agency (individuality) and communion (togetherness) are vital to a positive sense of self. People with Alzheimer's disease are at risk of experiencing diminished agency and decreased communion. Their family members', especially their partner's, view on their agency and communion is also likely to influence their sense of agency, communion, and self. In the present study, individual interviews with 10 people with Alzheimer's disease and their spousal carers were qualitatively analysed to describe how in each couple the two spouses viewed the agency and communion of the person with Alzheimer's disease from an individual perspective...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28440630/a-hydrolytically-stable-luminescent-cationic-metal-organic-framework-for-highly-sensitive-and-selective-sensing-of-chromate-anion-in-natural-water-systems
#2
Wei Liu, Yanlong Wang, Zhuanling Bai, Yuxiang Li, Yaxing Wang, Lanhua Chen, Lin Xu, Juan Diwu, Zhifang Chai, Shuao Wang
The effective detection of chromate anion in aqueous solution is highly desirable due to its high solubility, environmental mobility, carcinogenicity, and bioaccumulation effect. New strategy for precise detection of chromate anion in the presence of large excess of other anions such as Cl-, NO3-, HCO3- in drinking water and natural water systems remains a challenge. Herein, a hydrolytically stable cationic luminescent europium(III) based metal organic framework (MOF) 1 is successfully synthesized and investigated as a luminescent sensor which exhibits instant and selective luminescence quenching property toward CrO42- in aqueous solutions...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436924/harnessing-the-promise-of-moral-distress-a-call-for-re-orientation
#3
Alisa Carse, Cynda Hylton Rushton
Despite over three decades of research into the sources and costs of what has become an "epidemic" of moral distress among healthcare professionals, spanning many clinical disciplines and roles, there has been little significant progress in effectively addressing moral distress. We believe the persistent sense of frustration, helplessness, and despair still dominating the clinical moral distress narrative signals a need for re-orientation in the way moral distress is understood and worked with. Most fundamentally, moral distress reveals moral investment and energy...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28436314/metabolomic-approaches-in-the-discovery-of-potential-urinary-biomarkers-of-drug-induced-liver-injury-dili
#4
Ana Margarida Araújo, Márcia Carvalho, Félix Carvalho, Maria de Lourdes Bastos, Paula Guedes de Pinho
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is substantial. Therefore, new biomarkers for early identification of hepatotoxicity during the drug discovery process are needed, thus resulting in lower development costs and safer drugs...
April 24, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28416095/self-and-other-agency-in-people-with-passivity-first-rank-symptoms-in-schizophrenia
#5
Kyran T Graham-Schmidt, Mathew T Martin-Iverson, Flavie A V Waters
Individuals with passivity (first-rank) symptoms report that their actions, thoughts and sensations are influenced or controlled by an external (non-self) agent. Passivity symptoms are closely linked to schizophrenia and related disorders yet they remain poorly understood. One dominant framework posits a role for deficits in the sense of agency. An important question is whether deficits in self-agency can be differentiated from other-agency in schizophrenia and passivity symptoms. This study aimed to evaluate self- and other-agency in 51 people with schizophrenia (n=20 current, 10 past, 21 no history of passivity symptoms), and 48 healthy controls...
April 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28413978/advances-and-challenges-in-drug-design-of-ppar%C3%AE-ligands
#6
Vinicius Gonçalves Maltarollo, Thales Kronenberger, Björn Windshügel, Carsten Wrenger, Gustavo Henrique Goulart Trossini, Kathia Maria Honorio
Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors activated by endogenous fatty acids and prostaglandins that are classified into three types: α, γ and δ, which have different functions and tissue distribution. PPAR modulators have been exploited to the treatment of important metabolic diseases, such as type 2 diabetes mellitus and metabolic syndrome, which are considered relevant epidemic diseases currently. Along the last decades, several studies have reported structural differences between the three PPAR subtypes associated with the discovery of selective ligands, dual and pan-agonists...
April 14, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28412643/my-action-lasts-longer-potential-link-between-subjective-time-and-agency-during-voluntary-action
#7
Shu Imaizumi, Tomohisa Asai
Time perception distorts across different phases of bodily movement. During motor execution, sensory feedback matching an internal sensorimotor prediction is perceived to last longer. The sensorimotor prediction also underlies sense of agency. We investigated association between subjective time and agency during voluntary action. Participants performed hand action while watching a video feedback of their hand with various delays to manipulate agency. The perceived duration and agency over the video feedback were judged...
April 13, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28410470/the-action-congruency-effect-on-the-feelings-of-agency
#8
Roberta Vastano, Thierry Pozzo, Marcel Brass
Previous studies suggest that the sense of agency (SoA), the feeling of control about one's own actions and ensuing effects is also generated during action selection processes. We investigate whether the conflict at the action selection stage induced by a supraliminal stimulus, modulates an implicit measure of SoA, namely intentional binding. Furthermore, we were interested to investigate the influence of different types of stimulus-response compatibility on SoA. To this aim we compared the influence of an automatic imitation task and a stroop-like task on intentional binding...
April 11, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28370705/ratiometric-hg2-ag-probes-with-orange-red-white-blue-fluorescence-response-constructed-by-integrating-vibration-induced-emission-with-an-aie-motif
#9
Yiru Li, Yang Liu, Haitao Zhou, Wei Chen, Ju Mei, Jianhua Su
Two novel ratiometric fluorometric probes 6a and 6b have been successfully designed and synthesized for the detection of Hg2+ and Ag+, respectively. Each of these probes is comprised of a 9,14-diphenyl-9,14-dihydrodibenzo[a,c]phenazine (DPAC) skeleton, a tetraphenylethylene (TPE) unit, and two thymine/adenine groups. In this proof-of-concept work, the DPAC unit featured with vibration-induced emission (VIE) characteristics serves as a dual-emission chromogen, while the TPE moiety which is noted for its aggregation-induced emission (AIE) properties functions mainly as a signal amplifier...
March 29, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28365489/subliminal-modulation-of-voluntary-action-experience-a-neuropsychological-investigation
#10
N Khalighinejad, A Kunnumpurath, C Bertini, E Ladavas, P Haggard
Human voluntary actions are often associated with a distinctive subjective experience termed 'sense of agency'. This experience could be a reconstructive inference triggered by monitoring one's actions and their outcomes, or a read-out of brain processes related to action preparation, or some hybrid of these. Participants pressed a key with the right index finger at a time of their own choice, while viewing a rotating clock. Occasionally they received a mild shock on the same finger. They were instructed to press the key as quickly as possible if they felt a shock...
March 10, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28328372/psychiatric-genomics-and-mental-health-treatment-setting-the-ethical-agenda
#11
Camillia Kong, Michael Dunn, Michael Parker
Realizing the benefits of translating psychiatric genomics research into mental health care is not straightforward. The translation process gives rise to ethical challenges that are distinctive from challenges posed within psychiatric genomics research itself, or that form part of the delivery of clinical psychiatric genetics services. This article outlines and considers three distinct ethical concerns posed by the process of translating genomic research into frontline psychiatric practice and policy making...
April 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28325711/investigating-the-perceptions-of-care-coordinators-on-using-behavior-theory-based-mobile-health-technology-with-medicaid-populations-a-grounded-theory-study
#12
Brittany Erika Sigler
BACKGROUND: Medicaid populations are less engaged in their health care than the rest of the population, translating to worse health outcomes and increased health care costs. Since theory-based mobile health (mHealth) interventions have been shown to increase patient engagement, mobile phones may be an optimal strategy to reach this population. With increased development of theory-based mHealth technology, these interventions must now be evaluated with these medically underserved populations in a real-world setting...
March 21, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28321973/cortical-and-subcortical-mechanisms-of-brain-machine-interfaces
#13
Silvia Marchesotti, Roberto Martuzzi, Aaron Schurger, Maria Laura Blefari, José R Del Millán, Hannes Bleuler, Olaf Blanke
Technical advances in the field of Brain-Machine Interfaces (BMIs) enable users to control a variety of external devices such as robotic arms, wheelchairs, virtual entities and communication systems through the decoding of brain signals in real time. Most BMI systems sample activity from restricted brain regions, typically the motor and premotor cortex, with limited spatial resolution. Despite the growing number of applications, the cortical and subcortical systems involved in BMI control are currently unknown at the whole-brain level...
March 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28299535/the-self-in-movement-being-identified-and-identifying-oneself-in-the-process-of-migration-and-asylum-seeking
#14
Meike Watzlawik, Ignacio Brescó de Luna
How migration influences the processes of identity development has been under longstanding scrutiny in the social sciences. Usually, stage models have been suggested, and different strategies for acculturation (e.g., integration, assimilation, separation, and marginalization) have been considered as ways to make sense of the psychological transformations of migrants as a group. On an individual level, however, identity development is a more complex endeavor: Identity does not just develop by itself, but is constructed as an ongoing process...
March 15, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28292639/oculomotor-prediction-a-window-into-the-psychotic-mind
#15
REVIEW
Katharine N Thakkar, Vaibhav A Diwadkar, Martin Rolfs
Psychosis - an impaired contact with reality - is a hallmark of schizophrenia. Many psychotic symptoms are associated with disruptions in agency - the sense that 'I' cause my actions. A failure to predict sensory consequences of one's own actions may underlie agency disturbances. Such predictions rely on corollary discharge (CD) signals, 'copies' of movement commands sent to sensory regions prior to action execution. Here, we make a case that the oculomotor system is a promising model for understanding CD in psychosis, building on advances in our understanding of the behavioral and neurophysiological correlates of CD associated with eye movements...
May 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28277248/electrochemical-biosensors-for-early-stage-zika-diagnostics
#16
REVIEW
Ajeet Kaushik, Sneham Tiwari, Rahul D Jayant, Arti Vashist, Roozbeh Nikkhah-Moshaie, Nazira El-Hage, Madhavan Nair
Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for efficient analytical devices to detect ZIKV infection. However, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of reverse transcriptase-PCR methods for rapid diagnostics...
April 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28251993/sense-of-agency-in-the-human-brain
#17
REVIEW
Patrick Haggard
In adult life, people normally know what they are doing. This experience of controlling one's own actions and, through them, the course of events in the outside world is called 'sense of agency'. It forms a central feature of human experience; however, the brain mechanisms that produce the sense of agency have only recently begun to be investigated systematically. This recent progress has been driven by the development of better measures of the experience of agency, improved design of cognitive and behavioural experiments, and a growing understanding of the brain circuits that generate this distinctive but elusive experience...
April 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28226290/changes-in-the-sense-of-agency-during-hypnosis-the-hungarian-version-of-the-sense-of-agency-rating-scale-soars-hu-and-its-relationship-with-phenomenological-aspects-of-consciousness
#18
András Költő, Vince Polito
Changes in the sense of agency are defining feature of hypnosis. The Sense of Agency Rating Scale (SOARS) is a 10-item questionnaire, administered after a hypnosis session to assess alteration in the sense of agency. In the present study, a Hungarian version of the measure (SOARS-HU) is presented. The SOARS-HU and the Phenomenology of Consciousness Inventory (PCI) were administered to 197 subjects following hypnotizability screening with the Harvard Group Scale of Hypnotic Susceptibility Scale, Form A (HGSHS:A)...
March 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28223954/a-principle-of-intentionality
#19
Charles K Turner
The mainstream theories and models of the physical sciences, including neuroscience, are all consistent with the principle of causality. Wholly causal explanations make sense of how things go, but are inherently value-neutral, providing no objective basis for true beliefs being better than false beliefs, nor for it being better to intend wisely than foolishly. Dennett (1987) makes a related point in calling the brain a syntactic (procedure-based) engine. He says that you cannot get to a semantic (meaning-based) engine from there...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28223666/-geriatric-oncology
#20
Satoko Maeno, Fumio Nagashima, Daisuke Naruge, Naohiro Okano, Kirio Kawai, Takaaki Kobayashi, Hiroshi Kitamura, Junji Furuse
The number of older adults in Japan is rising, and healthcare for older patients differs from those of younger patients.We have limited available data regarding the outcomes of cancer treatment in this population.In addition, we have few guidelines to address the evaluation and treatment of older cancer patients in Japan.The Japan Agency for Medical Research and Development(AMED)has funded clinical research focusing on elderly cancer patients.We organized the Geriatric Study Committee in Japan Clinical Oncology Group(JCOG)to develop geriatric research policy in this area...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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