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Macrolide AND pneumonia

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https://www.readbyqxmd.com/read/29221755/unilateral-brachial-plexopathy-a-rare-complication-of-mycoplasma-pneumoniae-infection
#1
Barbara Robnik, Darja Keše, Tereza Rojko, Alenka Horvat-Ledinek, Aleš Pražnikar, Bojana Beović
Few reports in the literature describe isolated peripheral neuropathies in relation to Mycoplasma pneumoniae infection without concurrent damage to the central nervous system. To our knowledge only a single case of mononeuritis multiplex with brachial plexus neuropathy coincident with M. pneumoniae has been documented until now. Here we present the first clinical case of lobar M. pneumoniae pneumonia in a 19-year-old female patient, where coincident neurological complications manifested as unilateral brachial plexus neuropathy, affecting axillar and suprascapular nerves...
December 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29212838/long-term-macrolides-in-diffuse-interstitial-lung-diseases
#2
REVIEW
Paola Faverio, Francesco Bini, Adriano Vaghi, Alberto Pesci
In the present review we provide currently available evidence for the use of macrolides in the treatment of diffuse interstitial lung diseases (ILDs). Up to now, research on macrolides has mainly focused on three areas. First, macrolides have shown some promising results in cellular models and case reports as antifibrotic agents, by promoting autophagy and clearance of intracellular protein aggregates and acting as regulators of surfactant homeostasis. Secondly, macrolides have an immunomodulatory effect, which has been applied in some organising pneumonia cases...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29212389/antimicrobial-therapy-of-macrolide-resistant-mycoplasma-pneumoniae-pneumonia-in-children
#3
Hyunju Lee, Ki Wook Yun, Hoan Jong Lee, Eun Hwa Choi
Mycoplasma pneumoniae is an important cause of community-acquired pneumonia in children and young adolescents. Macrolides are recommended as the first-line therapy however, macrolide resistance rates in M. pneumoniae among children have been increasing substantially. Areas covered: This review focused on clinical characteristics and treatment of macrolide-resistant M. pneumoniae pneumonia in children. Expert commentary: Antibiotic choice should be based on in vitro activity, clinical efficacy and in consideration of potential adverse events...
December 7, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29201017/characterization-of-metagenomes-in-urban-aquatic-compartments-reveals-high-prevalence-of-clinically-relevant-antibiotic-resistance-genes-in-wastewaters
#4
Charmaine Ng, Martin Tay, Boonfei Tan, Thai-Hoang Le, Laurence Haller, Hongjie Chen, Tse H Koh, Timothy M S Barkham, Karina Y-H Gin
The dissemination of antimicrobial resistance (AMR) is an escalating problem and a threat to public health. Comparative metagenomics was used to investigate the occurrence of antibiotic resistant genes (ARGs) in wastewater and urban surface water environments in Singapore. Hospital and municipal wastewater (n = 6) were found to have higher diversity and average abundance of ARGs (303 ARG subtypes, 197,816 x/Gb) compared to treated wastewater effluent (n = 2, 58 ARG subtypes, 2,692 x/Gb) and surface water (n = 5, 35 subtypes, 7,985 x/Gb)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29200249/decision-and-cost-analysis-of-empirical-antibiotic-therapy-of-acute-sinusitis-in-the-era-of-increasing-antimicrobial-resistance-do-we-have-an-additional-tool-for-antibiotic-policy-decisions
#5
(no author information available yet)
OBJECTIVE: No previous analyses have attempted to determine optimal therapy for upper respiratory tract infections on the basis of cost-minimization models and the prevalence of antimicrobial resistance among respiratory pathogens in Slovakia. This investigation compares macrolides and cephalosporines for empirical therapy and look at this new tool from the aspect of potential antibiotic policy decision-making process. METHODS: We employed a decision tree model to determine the threshold level of macrolides and cephalosporines resistance among community respiratory pathogens that would make cephalosporines or macrolides cost-minimising...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29175796/antimicrobial-susceptibility-of-organisms-isolated-from-sputum-culture-of-karachi-pakistan
#6
Salman Mansoor, Shayan Qadir, Sehrish Javed, Faisal Shah Jehan, Maryam Kundi
Our study aims to contribute to developing antibiotics prescription guidelines at a national and a regional level directed by the antibiotics susceptibility patterns and rapidly emerging resistant organisms. This study is designed to observe the antimicrobial susceptibility in sputum culture isolates and drug resistance patterns against various antimicrobials. This was a retrospective cohort study; data was collected from two laboratories from 1st Jan to 15 July 2007. All laboratory reports were analyzed using SPSS version 19...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29163422/a-novel-inca-c1-group-conjugative-plasmid-encoding-vim-1-metallo-beta-lactamase-mediates-the-acquisition-of-carbapenem-resistance-in-st104-klebsiella-pneumoniae-isolates-from-neonates-in-the-intensive-care-unit-of-v-monaldi-hospital-in-naples
#7
Eliana P Esposito, Stefano Gaiarsa, Mariateresa Del Franco, Valeria Crivaro, Mariano Bernardo, Susanna Cuccurullo, Francesca Pennino, Maria Triassi, Piero Marone, Davide Sassera, Raffaele Zarrilli
The emergence of carbapenemase producing Enterobacteriaceae has raised major public health concern. The aim of this study was to investigate the molecular epidemiology and the mechanism of carbapenem resistance acquisition of multidrug-resistant Klebsiella pneumoniae isolates from 20 neonates in the neonatal intensive care unit (NICU) of the V. Monaldi Hospital in Naples, Italy, from April 2015 to March 2016. Genotype analysis by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) identified PFGE type A and subtypes A1 and A2 in 17, 2, and 1 isolates, respectively, and assigned all isolates to sequence type (ST) 104...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29155089/genotyping-and-macrolide-resistance-of-mycoplasma-pneumoniae-identified-in-children-with-community-acquired-pneumonia-cap-in-medellin-colombia
#8
Angela Rocio Copete, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Lázaro Agustín Vélez
OBJECTIVES: Our aim was to describe the genotypes and the main characteristics of the CAP cases caused by M. pneumoniae in hospitalized children in Medellin and in neighboring municipalities in 2011-2012. METHODOLOGY: The M. pneumoniae genotype was determined by PCR and sequencing of the p1 and 23S rRNA genes from induced sputum samples and nasopharyngeal swabs (NPS) from children with CAP who were hospitalized in 13 healthcare centers. In addition, a spatio-temporal analysis was performed to identify the potential risk areas and clustering of the cases over time...
November 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29132466/-association-of-drug-resistance-of-mycoplasma-pneumoniae-with-dna-load-and-genotypes-in-children-with-mycoplasma-pneumoniae-pneumonia
#9
Hui-Fen Zhang, Hai-Tao Bai, Ji-Ming Li, Hui Xie, Ye Wang
OBJECTIVE: To investigate the association of drug resistance of Mycoplasma pneumoniae (MP) with DNA load and genotypes in children with MP pneumonia. METHODS: A total of 230 children who were hospitalized and diagnosed with MP pneumonia between January 2012 and December 2016 were enrolled. Throat swabs were collected from the 230 children, and a rapid drug sensitivity assay was used to determine the sensitivity of clinical isolates of MP to nine commonly used antibacterial agents...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29115289/synthesis-and-antibacterial-activity-of-novel-lincomycin-derivatives-iv-optimization-of-an-n-6-substituent
#10
Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Yoko Hirai, Keiko Yamada, Keiichi Ajito
The design and synthesis of lincomycin derivatives modified at the C-6 and C-7 positions are described. A substituent at the C-7 position is a 5-aryl-1,3,4-thiadiazol-2-yl-thio group that generates antibacterial activities against macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes carrying an erm gene. An additional modification at the C-6 position was explored in application of information regarding pirlimycin and other related compounds. These dual modifications were accomplished by using methyl α-thiolincosaminide as a starting material...
November 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29111412/serotype-distribution-and-antibiotic-susceptibility-of-streptococcus-pneumoniae-strains-in-the-south-of-tunisia-a-five-year-study-2012-2016-of-pediatric-and-adult-populations
#11
Sonia Ktari, Ikram Jmal, Manel Mroua, Sonda Maalej, Nour ElHouda Ben Ayed, Basma Mnif, Faouzia Rhimi, Adnene Hammami
OBJECTIVES: To analyze the serotype distribution of Streptococcus pneumoniae clinical isolates collected in the south of Tunisia over a 5-year period in different age groups and to assess their antimicrobial susceptibility patterns. METHODS: A total of 305 non-duplicate S. pneumoniae isolates were collected between January 2012 and December 2016 at the university hospital in Sfax, Tunisia. All isolates were serotyped by multiplex PCR. The antibiotic susceptibility of all isolates was determined using the disk diffusion test or Etest assay...
October 27, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29107789/overcoming-the-challenges-of-low-drug-solubility-in-the-intravenous-formulation-of-solithromycin
#12
Daniel Evans, Samuel Yalkowsky, Sara Wu, David Pereira, Prabha Fernandes
Solithromycin is a fluoro-ketolide (a fourth-generation macrolide) antibiotic that has been undergoing clinical trials for the treatment of community acquired bacterial pneumonia. In this study, development of the tri-amino acid buffered solithromycin intravenous (IV) formulation was performed to minimize the occurrence of infusion associated local adverse events (infusion site pain or phlebitis) observed in patients who received the tartaric acid buffered IV formulation with a lower buffered capacity during Phase I clinical trials...
October 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29096010/macrolides-in-children-with-community-acquired-pneumonia-panacea-or-placebo
#13
Christopher C Blyth, Jeffrey S Gerber
Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromycin, and azithromycin, are prescribed frequently to children with acute lower respiratory infection. However, the significance of detecting "atypical" pathogens, including M pneumoniae, in children remains contentious...
October 31, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29095244/contribution-of-co-detected-respiratory-viruses-and-patient-age-to-the-clinical-manifestations-of-mycoplasma-pneumoniae-pneumonia-in-children
#14
Mi Seon Han, Ki Wook Yun, Hoan Jong Lee, Ji Young Park, Kyuyol Rhie, Joon Kee Lee, Hyunju Lee, Young Ho Kwak, Do Kyun Kim, Dong In Suh, Eun Hwa Choi
BACKGROUND: The clinical spectrum of Mycoplasma pneumoniae pneumonia is widely variable. This study evaluated the clinical manifestations of Mycoplasma pneumoniae pneumonia in children of different age groups and by the presence of co-detected respiratory virus. METHODS: This study included children hospitalized with M. pneumoniae pneumonia between 2010 and 2015. At the time of pneumonia diagnosis, a nasopharyngeal aspirate was analyzed for respiratory viruses by RT-PCR...
October 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29093323/multiple-locus-variable-number-tandem-repeat-analysis-of-mycoplasma-pneumoniae-isolates-between-2004-and-2014-in-yamagata-japan-change-of-molecular-characteristics-during-an-11-year-period
#15
Yu Suzuki, Junji Seto, Yoshitaka Shimotai, Tsutomu Itagaki, Yuriko Katsushima, Fumio Katsushima, Tatsuya Ikeda, Katsumi Mizuta, Seiji Hongo, Yoko Matsuzaki
Multiple-locus variable-number tandem-repeat analysis (MLVA) typing was performed of Mycoplasma pneumoniae strains isolated between 2004 and 2014 in Yamagata, Japan. The results were examined by combining P1 type and prevalence of macrolide resistance-associated mutations. Four-locus (Mpn13-16) MLVA classified 347 strains into nine MLVA types, including three major types: 3-5-6-2, 4-5-7-2, and 4-5-7-3. All type 3-5-6-2 strains (77 strains) were P1 type 2 variants (2a or 2c), while types 4-5-7-2 (181 strains) and 4-5-7-3 (75 strains) were P1 type 1...
October 31, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29084336/effectiveness-of-%C3%AE-lactam-monotherapy-vs-macrolide-combination-therapy-for-children-hospitalized-with-pneumonia
#16
Derek J Williams, Kathryn M Edwards, Wesley H Self, Yuwei Zhu, Sandra R Arnold, Jonathan A McCullers, Krow Ampofo, Andrew T Pavia, Evan J Anderson, Lauri A Hicks, Anna M Bramley, Seema Jain, Carlos G Grijalva
Importance: β-Lactam monotherapy and β-lactam plus macrolide combination therapy are both common empirical treatment strategies for children hospitalized with pneumonia, but few studies have evaluated the effectiveness of these 2 treatment approaches. Objective: To compare the effectiveness of β-lactam monotherapy vs β-lactam plus macrolide combination therapy among a cohort of children hospitalized with pneumonia. Design, Setting, and Participants: We analyzed data from the Etiology of Pneumonia in the Community Study, a multicenter, prospective, population-based study of community-acquired pneumonia hospitalizations conducted from January 1, 2010, to June 30, 2012, in 3 children's hospitals in Nashville, Tennessee; Memphis, Tennessee; and Salt Lake City, Utah...
December 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29084314/macrolides-and-pediatric-community-acquired-pneumonia-time-for-a-paradigm-shift
#17
Michael J Smith
No abstract text is available yet for this article.
October 30, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29077003/antibiotic-prescribing-for-uncomplicated-acute-bronchitis-is-highest-in-younger-adults
#18
Larissa Grigoryan, Roger Zoorob, Jesal Shah, Haijun Wang, Monisha Arya, Barbara W Trautner
Reducing inappropriate antibiotic prescribing is currently a global health priority. Current guidelines recommend against antibiotic treatment for acute uncomplicated bronchitis. We studied antibiotic prescribing patterns for uncomplicated acute bronchitis and identified predictors of inappropriate antibiotic prescribing. We used the Epic Clarity database (electronic medical record system) to identify all adult patients with acute bronchitis in family medicine clinics from 2011 to 2016. We excluded factors that could justify antibiotic use, such as suspected pneumonia, COPD or immunocompromising conditions...
October 27, 2017: Antibiotics
https://www.readbyqxmd.com/read/29063318/method-of-selection-of-bacteria-antibiotic-resistance-genes-based-on-clustering-of-similar-nucleotide-sequences
#19
I S Balashov, V A Naumov, P I Borovikov, A B Gordeev, D V Dubodelov, L A Lyubasovskaya, Yu V Rodchenko, A A Bystritskii, N V Aleksandrova, D Yu Trofimov, T V Priputnevich
A new method for selection of bacterium antibiotic resistance genes is proposed and tested for solving the problems related to selection of primers for PCR assay. The method implies clustering of similar nucleotide sequences and selection of group primers for all genes of each cluster. Clustering of resistance genes for six groups of antibiotics (aminoglycosides, β-lactams, fluoroquinolones, glycopeptides, macrolides and lincosamides, and fusidic acid) was performed. The method was tested for 81 strains of bacteria of different genera isolated from patients (K...
October 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29052538/antimicrobial-resistance-in-rhodococcus-equi
#20
Steeve Giguère, Londa J Berghaus, Jennifer M Willingham-Lane
Pneumonia caused by Rhodococcus equi remains an important cause of disease and death in foals. The combination of a macrolide (erythromycin, azithromycin, or clarithromycin) with rifampin has been the recommended treatment for foals with clinical signs of infection caused by R. equi since the early 1980s with, until recently, only rare reports of resistance. Resistance to macrolides and rifampin in isolates of R. equi cultured from horses is increasing, with isolates resistant to all macrolides and rifampin now being cultured from up to 40% of infected foals at some farms...
October 2017: Microbiology Spectrum
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