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https://www.readbyqxmd.com/read/29670792/pyogenic-spondylitis-caused-by-methicillin-resistant-staphylococcus-aureus-associated-with-tracheostomy-followed-by-resection-of-ossification-of-the-anterior-longitudinal-ligament
#1
Michio Hongo, Naohisa Miyakoshi, Masashi Fujii, Yuji Kasukawa, Yoshinori Ishikawa, Daisuke Kudo, Yoichi Shimada
Symptomatic ossification of the anterior longitudinal ligament (OALL) is rare. However, when the osteophyte enlarges and obstructive symptoms occur, the patient may require surgery. We present a case of pyogenic spondylitis caused by methicillin-resistant Staphylococcus aureus associated with tracheostomy followed by resection of OALL. A 69-year-old woman with OALL complained of dysphagia and suffocation, which was caused by prominent OALL at C4-5. Tracheostomy was performed, followed by osteophytectomy 6 weeks later...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29669593/association-between-general-joint-hypermobility-and-knee-hip-and-lumbar-spine-osteoarthritis-by-race-a-cross-sectional-study
#2
Portia P E Flowers, Rebecca J Cleveland, Todd A Schwartz, Amanda E Nelson, Virginia B Kraus, Howard J Hillstrom, Adam P Goode, Marian T Hannan, Jordan B Renner, Joanne M Jordan, Yvonne M Golightly
BACKGROUND: Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). METHODS: Data were from the Johnston County OA project, collected 2003-2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back...
April 18, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29661110/alteration-of-gait-parameters-in-a-mouse-model-of-surgically-induced-knee-osteoarthritis
#3
Yuma Makii, Meiko Asaka, Susumu Setogawa, Soichiro Fujiki, Yoko Hosaka, Fumiko Yano, Hiroyuki Oka, Sakae Tanaka, Naoshi Fukui, Dai Yanagihara, Taku Saito
PURPOSE: Joint pain is the most common symptom of osteoarthritis (OA); however, its mechanism remains unclarified. The present study investigated hindlimb motion during locomotion on the treadmill using a three-dimensional (3D) motion analysis system with high-speed cameras to evaluate whether this method can be used as an indication of joint pain in a mouse model of surgically induced OA. METHODS: We resected the medial meniscus and medial collateral ligament in 8-week old C57BL/6 male mice and performed locomotion recording 6 months post-operatively...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29657142/age-and-sex-dependent-frequency-of-fat-metaplasia-and-other-structural-changes-of-the-sacroiliac-joints-in-patients-without-axial-spondyloarthritis-a-retrospective-cross-sectional-mri-study
#4
Katharina Ziegeler, Hamama Eshkal, Claudia Schorr, Joachim Sieper, Torsten Diekhoff, Marcus R Makowski, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVE: To determine the prevalence of fat metaplasia and other structural lesions of the sacroiliac joints associated with axial spondyloarthritis in a nonrheumatological patient population. METHODS: Magnetic resonance imaging examinations that included the pelvis and were performed in patients without known rheumatological disease were used for this retrospective cross-sectional study. These images were evaluated for sacroiliac fat metaplasia, sclerosis, osteophytes, and joint space alterations such as erosions or ankylosis...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#5
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29651769/superolateral-hoffa-s-fat-pad-shfp-oedema-and-patellar-cartilage-volume-loss-quantitative-analysis-using-longitudinal-data-from-the-foundation-for-the-national-institute-of-health-fnih-osteoarthritis-biomarkers-consortium
#6
Arya Haj-Mirzaian, Ali Guermazi, Nima Hafezi-Nejad, Christopher Sereni, Michael Hakky, David J Hunter, Bashir Zikria, Frank W Roemer, Shadpour Demehri
OBJECTIVES: To determine the association of superolateral Hoffa's fat pad (SHFP) oedema and patellofemoral joint structural damage in participants of Foundation for the National Institute of Health Osteoarthritis Biomarkers Consortium study. METHODS: Baseline and 24-month MRIs of 600 subjects were assessed. The presence of SHFP oedema (using 0-3 grading scale) and patellar morphology metrics were determined using baseline MRI. Quantitative patellar cartilage volume and semi-quantitative MRI osteoarthritis knee score (MOAKS) variables were extracted...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29622035/ccl17-blockade-as-a-therapy-for-osteoarthritis-pain-and-disease
#7
Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Förster, John A Hamilton, Andrew D Cook
BACKGROUND: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→interferon regulatory factor 4 (IRF4)→chemokine (c-c motif) ligand 17 (CCL17) pathway, which is important for the development of inflammatory arthritis pain and disease. Tumour necrosis factor (TNF) can also be linked with this pathway. Here we investigated the involvement of the pathway in OA pain and disease development using the GM-CSF-dependent collagenase-induced OA (CiOA) model...
April 5, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29608037/pain-and-structural-alterations-in-knee-joints-in-patients-with-haemophilia
#8
S Krüger, M Hoffmeister, T Hilberg
INTRODUCTION: Patients with haemophilia (PwH) suffer from haemophilic arthropathy which leads to an enhanced pain sensitivity. The aim of this study was to determine whether the individual pain condition in terms of pressure pain thresholds (PPT) at the knee joints is linked to changes of underlying anatomical structures in PwH. MATERIAL AND METHODS: Eleven landmarks at both knee joints of 36 PwH and 36 controls were examined in terms of PPT and ultrasound sonography (US)...
April 2, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29581944/osseous-changes-in-the-temporomandibular-joint-in-rheumatoid-arthritis-a-cone-beam-computed-tomography-study
#9
Ola Mohamed Rehan, Hoda Abdel Kader Saleh, Hala Ahmed Raffat, Noha Saleh Abu-Taleb
Purpose: To evaluate osseous changes of temporomandibular joint (TMJ) in patients with rheumatoid arthritis (RA) using cone-beam computed tomography (CBCT) and to correlate the imaging findings with the severity of TMJ dysfunction, clinical findings, and laboratory findings. Materials and Methods: This study consisted of 28 subjects, including 14 RA patients and 14 controls, who were scheduled to undergo CBCT imaging for the diagnosis of a complaint not related to or affecting the TMJ...
March 2018: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29575548/evidence-that-mir-146a-attenuates-aging-and-trauma-induced-osteoarthritis-by-inhibiting-notch1-il-6-and-il-1-mediated-catabolism
#10
Ying-Jie Guan, Jing Li, Xu Yang, Shaohua Du, Jing Ding, Yun Gao, Ying Zhang, Kun Yang, Qian Chen
Primary osteoarthritis (OA) is associated with aging, while post-traumatic OA (PTOA) is associated with mechanical injury and inflammation. It is not clear whether the two types of osteoarthritis share common mechanisms. We found that miR-146a, a microRNA-associated with inflammation, is activated by cyclic load in the physiological range but suppressed by mechanical overload in human articular chondrocytes. Furthermore, miR-146a expression is decreased in the OA lesions of human articular cartilage. To understand the role of miR-146a in osteoarthritis, we systemically characterized mice in which miR-146a is either deficient in whole body or overexpressed in chondrogenic cells specifically...
March 24, 2018: Aging Cell
https://www.readbyqxmd.com/read/29554899/effects-of-stanozolol-on-normal-and-il-1%C3%AE-stimulated-equine-chondrocytes-in-vitro
#11
Mariana Castro Martins, Mandy J Peffers, Katie Lee, Luis M Rubio-Martinez
BACKGROUND: Intra-articular administration of stanozolol has shown promising results by improving the clinical management of lameness associated with naturally-occurring osteoarthritis (OA) in horses, and by decreasing osteophyte formation and subchondral bone reaction in sheep following surgically induced OA. However, there is limited evidence on the anti-inflammatory and modulatory properties of stanozolol on articular tissues. The objective of the current study was to evaluate the effects of stanozolol on chondrocyte viability and gene expression in normal equine chondrocytes and an inflammatory in vitro system of OA (interleukin-1β (IL-1β) treated chondrocytes)...
March 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29549054/knocking-out-or-pharmaceutical-inhibition-of-fatty-acid-binding-protein-4-fabp4-alleviates-osteoarthritis-induced-by-high-fat-diet-in-mice
#12
Chaofan Zhang, Kwong Yuen Chiu, Boris Pok Man Chan, Teng Li, Chunyi Wen, Aimin Xu, Chun Hoi Yan
OBJECTIVES: Adipokines play roles in the pathogenesis of osteoarthritis (OA). Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. The aim of this study was to discover the potential role of FABP4 in OA. METHODS: Seventy-two FABP4 knockout mice (KO) in C57BL/6N background and wild-type littermates (WT) (male, 6-week-old) were fed with a high-fat diet (HFD, 60% calorie) or standard diet (STD, 11...
March 13, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29540952/cricoid-and-cervical-osteophytes-causing-dysphagia-an-extremely-rare-and-interesting-case
#13
Puneet Gupta, Manik Mahajan, Poonam Sharma, Arti Khurana, Indu Bhasin
No abstract text is available yet for this article.
January 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29538033/lumbar-osteophyte-avid-on-68ga-prostate-specific-membrane-antigen-pet-ct
#14
Mads Ryø Jochumsen, Michael Alle Madsen, Lise Gammelgaard, Kirsten Bouchelouche
A 75-year-old man with recently diagnosed high-risk prostate cancer was referred for primary staging with Ga-prostate-specific membrane antigen (PSMA) PET/CT. The scan revealed intense Ga-PSMA uptake in a lumbar osteophyte on the right side of level L2/L3, whereas several other spinal osteophytes showed no Ga-PSMA uptake. MRI findings in the L3 vertebra was consistent with a benign Modic type 1 lesion, but MRI showed no signs of malignancy in the osteophyte with high Ga-PMSA uptake. This case presents an osteophyte as an addition to the list of potential benign pitfalls to be aware of when interpreting Ga-PSMA PET/CT...
March 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29531783/atlas-for-the-omeract-thumb-base-osteoarthritis-mri-scoring-system-toms
#15
REVIEW
Féline P B Kroon, Charles G Peterfy, Philip G Conaghan, Violaine Foltz, Frédérique Gandjbakhch, Iris Eshed, Harry K Genant, Mikkel Østergaard, Monique Reijnierse, Johan L Bloem, Ida K Haugen, Margreet Kloppenburg
This paper presents an atlas for the Outcome Measures in Rheumatology Clinical Trials (OMERACT) thumb base osteoarthritis MRI scoring system (TOMS). The atlas includes reference images of each grade of each feature that is assessed in TOMS (synovitis grade 0-3, subchondral bone defects grade 0-3, osteophytes grade 0-3, cartilage assessment grade 0-3, subluxation and bone marrow lesions grade 0-3) in the first carpometacarpal and scapho-trapezio-trapezoid joint. The presented reference images can be used to guide scoring of thumb base MRIs in patients with hand osteoarthritis according to the OMERACT TOMS...
2018: RMD Open
https://www.readbyqxmd.com/read/29523155/the-selective-cathepsin-k-inhibitor-miv-711-attenuates-joint-pathology-in-experimental-animal-models-of-osteoarthritis
#16
Erik Lindström, Biljana Rizoska, Karin Tunblad, Charlotte Edenius, Alison M Bendele, Don Maul, Michael Larson, Neha Shah, Valerie Yoder Otto, Chris Jerome, Urszula Grabowska
BACKGROUND: MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transection (ACLT), and the prophylactic effects on joint pathology in dogs subjected to partial medial meniscectomy, two surgical models of osteoarthritis (OA). METHODS: Starting 1 week after surgery, rabbits were dosed daily via oral gavage with either MIV-711 or vehicle (n = 7/group) for 7 weeks...
March 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29521748/delayed-diagnosis-of-gorlin-goltz-syndrome-the-importance-of-the-multidisciplinary-approach
#17
Jéssica Araújo Figueira, Fábio Roberto de Souza Batista, Karina Rosso, Vanessa Cristina Veltrini, Angelo José Pavan
Gorlin-Goltz syndrome (GGS), also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder with high penetrance and variable expressivity. The classic triad originally described by Gorlin and Goltz in 1960 is composed of multiple nevoid basal cell carcinomas (NBCCs), odontogenic keratocysts (OKCs) in the jaws and bifid ribs. in 1977, this triad was modified by Rayner et al, and to GGS diagnosis, the OKCs had to appear in combination with calcification of the cerebellar falx or palmar and plantar pits...
March 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29520537/radiological-glenohumeral-osteoarthritis-in-long-term-type-1-diabetes-prevalence-and-reliability-of-three-classification-systems-the-dialong-shoulder-study
#18
Niels Gunnar Juel, Jens I Brox, Johan C Hellund, Else Merckoll, Kristine B Holte, Tore J Berg
OBJECTIVE: In the present study, we evaluate the intra- and interrater agreement of radiological glenohumeral OA using three different classification systems and estimate the prevalence of radiological and clinical glenohumeral OA in patients with type 1 diabetes mellitus (DM1), for over 45 years and controls (The Dialong study). MATERIALS AND METHODS: We included 102 patients with DM1 (49% women, mean age, 61.9 years) and 73 controls (57% women, mean age, 62...
March 8, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29517667/aggravation-and-subsequent-disappearance-of-cervical-disc-herniation-after-cervical-open-door-laminoplasty-a-case-report
#19
Yang Meng, Xiaofei Wang, Beiyu Wang, Tingkui Wu, Hao Liu
RATIONALE: Cervical open-door laminoplasty can enlarge the volume of the cervical vertebral canal and thus has become an effective and safe treatment for multilevel cervical disc herniation and cervical stenosis. Some post-surgery complications exist, such as reduction of cervical alignment and local kyphosis. However, aggravation of cervical disc herniation at the surgical level during short-term follow-up has not been discussed. Additionally, spontaneous disappearance of herniated disc pulposus is a common phenomenon in the lumbar region but is relatively rare in the cervical region...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29501222/predictive-findings-on-magnetic-resonance-imaging-in-patients-with-symptomatic-acromioclavicular-osteoarthritis
#20
Egbert J D Veen, Cornelia M Donders, Robin E Westerbeek, Rosalie P H Derks, Ellie B M Landman, Cornelis T Koorevaar
BACKGROUND: A magnetic resonance imaging (MRI) scan of the shoulder can have added value in diagnosing symptomatic osteoarthritis of the acromioclavicular (AC) joint. Specific MRI signs have been recognized but not analyzed extensively before. This study aims to identify predictive MRI signs in patients with symptomatic AC osteoarthritis. METHODS: The MRI scans of 70 patients with symptomatic AC osteoarthritis were compared with those of 70 patients with subacromial pain syndrome and no clinical signs of symptomatic AC osteoarthritis...
February 28, 2018: Journal of Shoulder and Elbow Surgery
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