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https://www.readbyqxmd.com/read/29782837/phenylalanine-and-tryptophan-stimulate-gastrin-and-somatostatin-secretion-and-h-k-atpase-activity-in-pigs-through-calcium-sensing-receptor
#1
Yihan Xian, Xiuying Zhao, Chao Wang, Cuicui Kang, Liren Ding, Weiyun Zhu, Suqin Hang
In rodents and humans, aromatic amino acids increase gut hormone secretion and H+ -K+ -ATPase activity by modulating calcium-sensing receptor (CaSR). However, the role of CaSR and its related signaling molecules in amino acid-induced gut hormone secretion in swine has not been investigated. Here, we examined whether a CaSR-dependent pathway modulated gastrin and somatostatin (SS) secretion and H+ -K+ -ATPase activity in pigs. Perfusion of pig stomach tissues in the presence of extracellular 80 mM l-phenylalanine (Phe) or 20 mM l-tryptophan (Trp) and a CaSR agonist cinacalcet triggered gastrin and SS secretion and H+ -K+ -ATPase activity (P < 0...
May 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29765436/anti-thyroid-antibodies-parietal-cell-antibodies-and-tissue-transglutaminase-antibodies-in-patients-with-autoimmune-thyroid-disease
#2
Orit Twito, Yonatan Shapiro, Aviva Golan-Cohen, Yoav Dickstein, Rosane Ness-Abramof, Menachem Shapiro
Introduction: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20-25%, and that of celiac antibodies is 2-5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. Material and methods: The files of 120 Israeli Jews and Arabs with ATD were evaluated for anti-thyroglobulin antibodies (Tg-Ab), anti-thyroid peroxidase antibodies (TPO-Ab), PC-Ab and tTG-Ab...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29733520/mango-mangifera-indica-l-polyphenols-ameliorate-functional-constipation-symptoms-in-humans-beyond-equivalent-amount-of-fiber
#3
Vinicius P Venancio, Hyemee Kim, Maritza A Sirven, Carmen D Tekwe, Gilson Honvoh, Stephen T Talcott, Susanne U Mertens-Talcott
SCOPE: Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and considerably impaired quality of life, affecting about 20% of Americans. Dietary fiber and laxatives aid in its treatment but do not fully address all symptoms, such as intestinal inflammation. Mango (Mangifera indica L.), a fiber- and polyphenol-rich fruit may provide anti-inflammatory effects in constipation. METHODS AND RESULTS: The 4-week consumption of mango fruit (300 g) or the equivalent amount of fiber was investigated in otherwise healthy human volunteers with chronic constipation that were randomly assigned to either group...
May 7, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29729162/interrelation-between-ghrelin-and-gastrin-in-patients-with-combination-of-chronic-gastritis-and-type-2-diabetes-mellitus
#4
Elizaveta S Sirchak, Silviya V Patskun
OBJECTIVE: Introduction: Ghrelin is 28-amino-acid peptide that is produced by X/A-like cells present in the stomach. Gastrin is a hormone that stimulates gastric acid secretion and mucosal cell growth. The aim: to study the interrelation between ghrelin and gastrin levels in patients with combination of chronic gastritis and type 2 diabetes mellitus. PATIENTS AND METHODS: Materials and methods: 60 Helicobacter pylori positive patients with a combination of chronic gastritis and type 2 diabetes mellitus were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29721096/first-in-human-study-of-pet-and-optical-dual-modality-image-guided-surgery-in-glioblastoma-using-68-ga-irdye800cw-bbn
#5
Deling Li, Jingjing Zhang, Chongwei Chi, Xiong Xiao, Junmei Wang, Lixin Lang, Iqbal Ali, Gang Niu, Liwei Zhang, Jie Tian, Nan Ji, Zhaohui Zhu, Xiaoyuan Chen
Purpose : Despite the use of fluorescence-guided surgery (FGS), maximum safe resection of glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons between preoperative diagnosis and intraoperative treatment. Currently, an integrated approach combining preoperative assessment with intraoperative guidance would be a significant step in this direction. Experimental design : We developed a novel 68 Ga-IRDye800CW-BBN PET/near-infrared fluorescence (NIRF) dual-modality imaging probe targeting gastrin-releasing peptide receptor (GRPR) in GBM...
2018: Theranostics
https://www.readbyqxmd.com/read/29720834/comparison-of-bran-processed-and-crude-atractylodes-lancea-effects-on-spleen-deficiency-syndrome-in-rats
#6
Dong-Hua Xue, Yu-Qiang Liu, Qian Cai, Ke Liang, Bing-Yuan Zheng, Fang-Xiao Li, Xue Pang
Background: The rhizome of Atractylodes lancea (AL) is usually used for the treatment of various diseases such as spleen deficiency syndrome (SDS). Both bran-processed and crude AL is included in Chinese Pharmacopoeia. The different efficacies of bran-processed and crude AL on SDS are largely unknown, and the mechanisms of AL effects have not been fully elucidated. Objective: The objective of the study was to compare the effects of bran-processed and crude AL and then assess the mechanisms of treating SDS...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29719814/transformation-to-small-cell-lung-cancer-after-first-line-afatinib-treatment
#7
Takayuki Shiroyama, Shingo Nasu, Ayako Tanaka, So Takata, Kentaro Masuhiro, Hiromune Takada, Satomu Morita, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Kunimitsu Kawahara, Tomonori Hirashima
Acquiring resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is inevitable. Transformation to small cell lung cancer (SCLC) is reported as a possible mechanism of this acquired resistance. We describe the case of a 35-year-old man with lung adenocarcinoma harboring EGFR exon 19 deletion. After 7 months of successful treatment with afatinib, he experienced relapse and rebiopsy revealed SCLC with EGFR exon 19 deletion. Tumor marker tests at this point showed normal levels of serum neuron-specific enolase and pro-gastrin releasing peptide...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29717112/gastrin-stimulates-pancreatic-cancer-cell-directional-migration-by-activating-the-g%C3%AE-12-13-rhoa-rock-signaling-pathway
#8
Ganggang Mu, Qianshan Ding, Hongyan Li, Li Zhang, Lingli Zhang, Ke He, Lu Wu, Yunchao Deng, Dongmei Yang, Lianlian Wu, Ming Xu, Jie Zhou, Honggang Yu
The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The process of directing polarized cancer cells toward the extracellular matrix is principally required for invasion and distant metastasis; however, whether gastrin can induce this process and its underlying mechanism remain to be elucidated. In this study, we found that gastrin-induced phosphorylation of paxillin at tyrosine 31/118 and RhoA activation as well as promoted the metastasis of PANC-1 cancer cells. Depletion of Gα12 and Gα13 inhibited the phosphorylation of paxillin and downstream activation of GTP-RhoA, blocked the formation and aggregation of focal adhesions and facilitated polarization of actin filaments induced by gastrin...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29707078/assessment-of-gastric-acidity-by-conventional-endoscopy-with-serological-gastric-markers
#9
Byung Chul Kim, Mi Ae Song, Sung Ho Kwon, Min Ji Kim
Background: Gastric acidity could determine Helicobacter pylori ( H. pylori )-associated gastritis patterns. In reverse, H. pylori infection could lead disturbance in gastric acid secretion. We attempted to elucidate gastric acid status by conventional endoscopy with pepsinogen test. Methods: A total of 196 subjects who visited our health promotion center were consecutively enrolled and evaluated by conventional endoscopy, and blood examinations with pepsinogen I, II, and fasting serum gastrin were conducted...
April 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29669290/non-canonical-opioid-signaling-inhibits-itch-transmission-in-the-spinal-cord-of-mice
#10
Admire Munanairi, Xian-Yu Liu, Devin M Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R Bruchas, Zhou-Feng Chen
Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the spinal cord, and KOR activation attenuated GRPR-mediated histamine-independent acute and chronic itch in mice. Notably, canonical KOR-mediated Gαi signaling is not required for desensitizing GRPR function...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29664606/radiometal-dependent-biological-profile-of-the-radiolabeled-grpr-antagonist-sb3-in-cancer-theranostics-metabolic-and-biodistribution-patterns-defined-by-neprilysin
#11
Emmanouil Lymperis, Aikaterini Kaloudi, Werner Sallegger, Ingrid L Bakker, Eric P Krenning, Marion DeJong, Theodosia Maina, Berthold Artur Nock
Recent advances in oncology involve the use of diagnostic/therapeutic radionuclide-carrier pairs that target cancer cells, offering exciting opportunities for personalized patient treatment. Theranostic gastrin-releasing peptide receptor (GRPR)-directed radiopeptides have been proposed for the management of GRPR-expressing prostate and breast cancers. We have recently introduced the PET tracer 68Ga-SB3 (SB3, DOTA-p-aminomethylaniline-diglycolic acid-DPhe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt), a receptor-radioantagonist that enables the visualization of GRPR-positive lesions in human...
April 17, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29662293/maintenance-for-healed-erosive-esophagitis-phase-iii-comparison-of-vonoprazan-with-lansoprazole
#12
Kiyoshi Ashida, Katsuhiko Iwakiri, Naoki Hiramatsu, Yuuichi Sakurai, Tetsuharu Hori, Kentarou Kudou, Akira Nishimura, Eiji Umegaki
AIM: To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis (EE). METHODS: A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg ( n = 201), vonoprazan 10 mg ( n = 202), or vonoprazan 20 mg ( n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29606921/overview-of-current-concepts-in-gastric-intestinal-metaplasia-and-gastric-cancer
#13
David S Jencks, Jason D Adam, Marie L Borum, Joyce M Koh, Sindu Stephen, David B Doman
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The pathogenesis to gastric cancer is proposed by the Correa hypothesis as the transition from normal gastric epithelium to invasive cancer via inflammation followed by intramucosal cancer and invasion. Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota...
February 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29599609/correlation-between-serum-vitamin-b12-level-and-peripheral-neuropathy-in-atrophic-gastritis
#14
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong
AIM: To explore the correlation between serum vitamin B12 level and peripheral neuropathy in patients with chronic atrophic gastritis (CAG). METHODS: A total of 593 patients diagnosed with chronic gastritis by gastroscopy and pathological examination from September 2013 to September 2016 were selected for this study. The age of these patients ranged within 18- to 75-years-old. Blood pressure, height and weight were measured in each patient, and the body mass index value was calculated...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29587283/old-and-new-gut-hormone-gastrin-and-acid-suppressive-therapy
#15
Ken Haruma, Tomoari Kamada, Noriaki Manabe, Mitsuhiko Suehiro, Hirofumi Kawamoto, Akiko Shiotani
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29564060/comparison-of-helicobacter-pylori-eradication-regimens-in-patients-with-end-stage-renal-disease
#16
Mohammadreza Seyyed Majidi, Peyman Sanjari Pirayvatlou, Majid Rajabikashani, Mona Firoozabadi, Seyed Ali Seyed Majidi, Jamshid Vafaeimanesh
Aim: The aim of this study was to compare the Helicobacter pylori (HP) eradication regimens in patients with end stage renal disease. Background: In patients undergoing hemodialysis, the pathologic changes seen in the stomach may be the result of high serum levels of gastrin, delayed gastric emptying or HP infection. Methods: Our study was a randomized clinical trial in which 120 patients with ESRD (Patients who undergo hemodialysis) confirmed HP infection, were divided to four groups having 2-week eradication regimens; Group I: LCA (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD, amoxicillin 500 mg-BD), Group II: LCM (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD, metronidazole 500 mg-BD), Group III: LCAM (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD,amoxicillin 500 mg-BD, metronidazole 500 mg-BD) and Group IV: Sequential (lansoprazole 30 mg-BDfor two weeks; first week: amoxicillin 500 mg-BD and second week: clarithromycin 250 mg-BD, metronidazole 500 mg-BD)...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29556947/in-vivo-stabilized-sb3-an-attractive-grpr-antagonist-for-pre-and-intra-operative-imaging-for-prostate-cancer
#17
Ingrid L Bakker, Sandra T van Tiel, Joost Haeck, Gabriela N Doeswijk, Erik de Blois, Marcel Segbers, Theodosia Maina, Berthold A Nock, Marion de Jong, Simone U Dalm
PURPOSE: The gastrin-releasing peptide receptor (GRPR), overexpressed on various tumor types, is an attractive target for receptor-mediated imaging and therapy. Another interesting approach would be the use of GRPR radioligands for pre-operative imaging and subsequent radio-guided surgery, with the goal to improve surgical outcome. GRPR radioligands were successfully implemented in clinical studies, especially Sarabesin 3 (SB3) is an appealing GRPR antagonist with high receptor affinity...
March 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29534195/effects-of-sex-steroids-on-the-spinal-gastrin-releasing-peptide-system-controlling-male-sexual-function-in-rats
#18
Takumi Oti, Keiko Takanami, Saya Ito, Takashi Ueda, Ken Ichi Matsuda, Mitsuhiro Kawata, Jintetsu Soh, Osamu Ukimura, Tatsuya Sakamoto, Hirotaka Sakamoto
The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord controls male sexual function in rats. In contrast, in female rats, GRP neurons could scarcely be detected around puberty when circulating ovarian steroid hormones such as estradiol and progesterone levels are increasing. However, little information is available on feminizing or demasculinizing effects of ovarian steroids on the central nervous system in female puberty and adulthood. In this study, to visualize the spinal GRP neurons in vivo, we generated a GRP-promoter-Venus transgenic (Tg) rat line and studied the effects of the sex steroid hormones on GRP expression in the rat lumbar cord by examining the Venus fluorescence...
April 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29527318/study-for-every-other-day-administration-of-vonoprazan-in-maintenance-treatment-of-erosive-gerd-study-protocol-for-a-multicentre-randomised-cross-over-study
#19
Mototsugu Kato, Noriko Ito, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29518896/use-of-metabolomics-as-a-complementary-omic-approach-to-implement-risk-criteria-for-first-degree-relatives-of-gastric-cancer-patients
#20
Giuseppe Corona, Renato Cannizzaro, Gianmaria Miolo, Laura Caggiari, Mariangela De Zorzi, Ombretta Repetto, Agostino Steffan, Valli De Re
A positive family history is a strong and consistently reported risk factor for gastric cancer (GC). So far, it has been demonstrated that serum pepsinogens (PGs), and gastrin 17 (G17) are useful for screening individuals at elevated risk to develop atrophic gastritis but they are suboptimal biomarkers to screen individuals for GC. The main purpose of this study was to investigate serum metabolomic profiles to find additional biomarkers that could be integrated with serum PGs and G17 to improve the diagnosis of GC and the selection of first-degree relatives (FDR) at higher risk of GC development...
March 7, 2018: International Journal of Molecular Sciences
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