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Skin source infections

Bushra Uzair, Sarah Bint-E-Irshad, Barkat Ali Khan, Beenish Azad, Tariq Mahmood, Mujaddad Ur Rehman, Valdir A Braga
BACKGROUND: Scorpion venom is the most expensive and deadly venom with exciting medical prospects and having a potential as a source of drug candidates. A number of scorpion venom peptides have shown promising site specificity and are involved in the regulation of biological mechanisms. Due to the structural and functional specificity, the scorpion peptides are widely used for the development of specific drugs especially for the cardiovascular and other immune diseases. In this review, we summarize scorpion venom's biological activities such as antimicrobial, antiviral, anti-cancerous and in immune diseases...
June 13, 2018: Protein and Peptide Letters
Boyang Qiu, Kait Al, Ana M Pena-Diaz, George S Athwal, Darren Drosdowech, Kenneth J Faber, Jeremy P Burton, David B O'Gorman
BACKGROUND: Advances in DNA sequencing technologies have made it possible to detect microbial genome sequences (microbiomes) within tissues once thought to be sterile. We used this approach to gain insights into the likely sources of Cutibacterium acnes (formerly Propionibacterium acnes) infections within the shoulder. METHODS: Tissue samples were collected from the skin, subcutaneous fat, anterior supraspinatus tendon, middle glenohumeral ligament, and humeral head cartilage of 23 patients (14 male and 9 female patients) during primary arthroplasty surgery...
June 13, 2018: Journal of Shoulder and Elbow Surgery
Randy W Loftus, Franklin Dexter, Alysha D M Robinson
BACKGROUND: Increased awareness of the epidemiology of transmission of pathogenic bacterial strain characteristics may help to improve compliance with intraoperative infection control measures. Our aim was to characterize the epidemiology of intraoperative transmission of high-risk Staphylococcus aureus sequence types (STs). METHODS: S aureus isolates collected from 3 academic medical centers underwent whole cell genome analysis, analytical profile indexing, and biofilm absorbance...
June 12, 2018: American Journal of Infection Control
Hiba Zaaroura, Yuval Geffen, Reuven Bergman, Emily Avitan-Hersh
Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. The clinical files, bacterial cultures and histopathology reports of all S. lugdunensis isolates from skin infections over a period of 8 years (September 2009-September 2017) were reviewed. S. lugdunensis was isolated from 29 patients with skin infections, aged 7-89 years (mean 33...
June 13, 2018: Journal of Dermatology
K O Opara, I C Nwagbara
Background: : The management of soft-tissue defects following surgery for chronic osteomyelitis of the tibia is challenging. It often requires complex reconstructive procedures, especially when the distal third of the tibia is involved. We present a relatively simple method of addressing these defects. Aim: : This study aims to report our experience with the use of the sural Island musculo fasciocutaneous flap in the management of osteomyelitis of the tibia. Materials and Methods: : Consecutive patients with osteomyelitis of the tibia requiring soft-tissue cover were managed using the sural Island musculo fasciocutaneous flap, and the outcome was analyzed...
June 2018: Nigerian Journal of Clinical Practice
Yingli Song, Xiaolan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
Group A Streptococcus (GAS) requires iron for growth, and heme is an important source of iron for GAS. Streptococcus heme transporter A (HtsA) is the lipoprotein component of the GAS heme-specific ABC transporter (HtsABC). The objective of this study is to examine the contribution of HtsABC to virulence and host interaction of hypervirulent M1T1 GAS using an isogenic htsA deletion mutant (Δ htsA ). The htsA deletion exhibited a significantly increased survival rate, reduced skin lesion size, and reduced systemic GAS dissemination in comparison to the wild type strain...
2018: Frontiers in Microbiology
Michael Benson, Moneer K Hanna
INTRODUCTION: Congenital scrotal agenesis (CSA) is an extremely rare condition with fewer than 10 cases reported in the literature. These patients are often further complicated by undescended testicles as well as systemic developmental disorders. Herein, we report our experience and an innovative surgical technique for creation of a neo-scrotum in three children. MATERIALS AND METHODS: We evaluated the records of three children in our database who were labeled as having an absent (1 patient) or severely underdeveloped scrotum (2 patients)...
May 5, 2018: Journal of Pediatric Urology
Annadurai Senthilkumar, Noushad Karuvantevida, Luca Rastrelli, Shyam S Kurup, Abdul J Cheruth
Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values. The plant parts are used in folk medicine for many human health care purposes including diabetes, wound healing, disinfectant, fever, constipation, muscle pains, slimness, burns, labor pain, hypertension, malaria, stomach disorder, asthma, skin problems, and to expel a retained placenta...
2018: Frontiers in Pharmacology
Raynell Lang, Jessica Minion, Stuart Skinner, Alexander Wong
BACKGROUND: Exophiala dermatitidis is a melanized fungus isolated from many environmental sources. Infections caused by Exophiala species are typically seen in immunocompromised hosts and manifest most commonly as cutaneous or subcutaneous disease. Systemic infections are exceedingly rare and associated with significant morbidity and mortality CASE PRESENTATION: A 28-year-old female originally from India presented with fevers, chills, weight loss and increasing back pain. She had a recent diffuse maculopapular rash that resulted in skin biopsy and a tentative diagnosis of sarcoidosis, leading to administration of azathioprine and prednisone...
June 4, 2018: BMC Infectious Diseases
Hossein Fazeli, Sharareh Moghim, Donya Zare
Background: Nosocomial infections are one of the most leading causes of morbidity and mortality in patients with cancer. The emergence of multiple-drug-resistant (MDR) strains of Gram-negative bacteria causing nosocomial infection has become a serious concern in cancer patients. Therefore, the present study aimed to determine the spectrum and antibiotic resistance pattern of Gram-negative bacteria related nosocomial infections among Iranian cancer patients. Materials and Methods: This descriptive cross-sectional study was conducted during the 6 months from December 2015 to May 2016 in two tertiary care centers located in Isfahan and Arak Province...
2018: Advanced Biomedical Research
Parisa Goodarzi, Sepideh Alavi-Moghadam, Masoumeh Sarvari, Akram Tayanloo Beik, Khadijeh Falahzadeh, Hamidreza Aghayan, Moloud Payab, Bagher Larijani, Kambiz Gilany, Fakher Rahim, Hossein Adibi, Babak Arjmand
Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient's general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge...
June 2, 2018: Advances in Experimental Medicine and Biology
Mariele De Santi, Caroline do Couto, Karin Werther
Digenetic eucotylids of the Paratanaisia genus are widely reported parasites of the avian renal system. The infection, commonly reported in free-living and zoo-housed birds, is described for the first time in a domiciled bird, a cockatiel kept as pet bird with free access to the yard outdoors. The bird was received at Veterinary Hospital, where clinical and radiographic evaluations suggested a case of heavy-metal poisoning. Although the bird received supportive care and a chelating agent, it died the next day...
May 24, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
S R Brailsford, J Tossell, R Morrison, C P McDonald, T L Pitt
BACKGROUND AND OBJECTIVES: Between February 2011 and December 2016, over 1·6 million platelet units, 36% pooled platelets, underwent bacterial screening prior to issue. Contamination rates for apheresis and pooled platelets were 0·02% and 0·07%, respectively. Staphylococcus aureus accounted for 21 contaminations, including four pooled platelets, one confirmed transfusion-transmitted infection (TTI) and three 'near-miss' incidents detected on visual inspection which were negative on screening...
May 24, 2018: Vox Sanguinis
Taylor J Ridley, Christopher T Rud, Aaron J Krych, Jeffrey A Macalena
Background: A sterile surgical marking pen is commonly used during anterior cruciate ligament reconstruction (ACLR) to outline the proposed skin incision and then to mark the graft during preparation. Once in contact with the skin, the pen is a potential source of bacterial transmission and subsequent infections after ACLR. Purpose/Hypothesis: The purpose of this study was to assess whether the skin marking pen is a fomite for contamination during arthroscopic ACLR...
May 2018: Orthopaedic Journal of Sports Medicine
Elena Vallino Costassa, Antonio D'Angelo, Maria Mazza, Daniela Meloni, Elisa Baioni, Cristiana Maurella, Silvia Colussi, Nicola Martinelli, Monica Lo Faro, Elena Berrone, Alessandra Favole, Paola Crociara, Silvia Grifoni, Marina Gallo, Guerino Lombardi, Barbara Iulini, Cristina Casalone, Cristiano Corona
Monitoring of small ruminants for transmissible spongiform encephalopathies (TSEs) has recently become more relevant after two natural scrapie suspected cases of goats were found to be positive for classical BSE (C-BSE). C-BSE probably established itself in this species unrecognized, undermining disease control measures. This opens the possibility that TSEs in goats may remain an animal source for human prion diseases. Currently, there are no data regarding the natural presence of the atypical BSE in caprines...
2018: PloS One
Jessica J Evans, Aaron Bost, Karim H Muci-Küchler, Linda C DeVeaux
BACKGROUND: Ballistics gelatin is a common tissue surrogate used in bacterial contamination models for projectile wounds. Although these studies have demonstrated that bacteria are transferred from the surface of the gelatin to the wound track by a projectile, quantifiable results have been inconsistent and not repeatable in successive tests. METHODS: In this study, five areas of a typical contamination model in which bacterial recovery or survival are affected were identified for optimization...
May 25, 2018: Military Medical Research
J S Munday, A A Cullum, N A Thomson, M Bestbier, T McCormack, A F Julian
CASE HISTORY: Anal warts were observed in heifers in two unrelated groups of animals. Heifers in one group developed visible warts 4 months after manual rectal examination and heifers in the other group developed warts 5 months after examination using a hand-held rectal ultrasound probe. CLINICAL FINDINGS: Large exophytic proliferative anal masses were observed in 5/15 (33%) heifers in one group and 13/149 (9%) heifers in the second group. Heifers in the second group were also noted to have similar masses on the underside of the tail at sites previously used for venepuncture and some of the heifers had skin warts...
May 23, 2018: New Zealand Veterinary Journal
Vanessa Aparecida Vilas-Boas, Carlos Emílio Levy, Maria Isabel Pedreira de Freitas, Kevin Woo
Surgical site infection (SSI) is a common complication that is associated with delayed recovery, prolonged length of hospital stay, exorbitant cost, and mortality. The present prospective longitudinal study aimed to evaluate the relationships between the microbial load of trocars used in laparoscopic gynecological surgery, microbiota in surgical sites, and SSI. The final sample consisted of 24 patients, including 68 swab samples and 48 trocars. Microorganisms were recovered in 100.0% of the swabs collected from the umbilicus and vaginal fornix and in 58...
June 1, 2018: Surgical Technology International
Shotaro Nakagun, Masako Okazaki, Takahito Toyotome, Nobuki Sugiyama, Kenichi Watanabe, Noriyuki Horiuchi, Yoshiyasu Kobayashi
A 4-year-old captive ringed seal (Pusa hispida) was treated with subcutaneous antibacterial injections for pus exuding wounds in the skin and associated blubber following a bite attack. Three months after the incident, the animal presented nystagmus and died the following day. At necropsy, there was a 25 × 18 × 25 mm well-delineated, opaque nodular mass in the lung, besides the skin ulcers and localized areas of discoloration in the blubber correlating with the bite wound and injection sites. Histopathology of the pulmonary mass demonstrated severe eosinophilic inflammatory infiltration among numerous intralesional fungal hyphae...
May 22, 2018: Mycopathologia
Kerstin Wernike, Anna Michelitsch, Andrea Aebischer, Uwe Schaarschmidt, Andrea Konrath, Hermann Nieper, Julia Sehl, Jens P Teifke, Martin Beer
The major source for the spread of bovine viral diarrhea virus (BVDV) are in-utero infected, immunotolerant, persistently infected (PI) animals since they shed enormous amounts of viruses throughout their lives. During the sequence-based virus typing of diagnostic ear notch samples performed in the context of the obligatory German BVDV eradication program, the commercial Npro and Erns double mutant BVDV-1 live-vaccine strain KE-9 was detected in seven newborn calves; their mothers were immunized in the first trimester of gestation...
May 19, 2018: Viruses
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