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Skin source infections

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https://www.readbyqxmd.com/read/29659450/aseptic-freeze-dried-vs-sterile-wet-packaged-human-cadaveric-acellular-dermal-matrix-adm-in-immediate-tissue-expander-breast-reconstruction-a-propensity-score-analysis-study
#1
Summer E Hanson, Jesse D Meaike, Jesse C Selber, Jun Liu, Liang Li, Victor J Hassid, Donald P Baumann, Charles E Butler, Patrick B Garvey
BACKGROUND: Although multiple acellular dermal matrix (ADM) sources exist, it is unclear how ADM processing impacts complication rates. We compared complications between two preparations of human cadaveric ADM (freeze dried [hADM-FD] and ready to use [hADM-RTU]) in immediate tissue expander (TE) breast reconstruction to analyze the effect of processing on complications. HADM-FD is aseptic while hADM-RTU is sterilized and wet-packaged. METHODS: We retrospectively reviewed all TE breast reconstructions with hADM-FD or hADM-RTU at a single center between 2006 and 2016...
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29657725/adherence-rate-of-quality-of-care-indicators-for-staphylococcus-aureus-bacteremia-is-extremely-low-in-japanese-emergency-and-critical-care-departments-a-multicenter-retrospective-observational-study
#2
Kyohei Miyamoto, Seiya Kato, Junichi Kitayama, Junpei Okawa, Ayana Okamoto, Jun Kamei, Kazuhisa Yoshiya, Hideki Asai, Shingo Adachi, Hidekazu Yukioka, Hiroshi Akimoto, Kazuo Okuchi
Aim: Staphylococcus aureus bacteremia causes significant morbidity and mortality and requires specific management to prevent complications. Most studies evaluating quality of care have been carried out in Europe and North America, and accurate epidemiological data are lacking in Asia. We aimed to describe the epidemiology and evaluate the quality of care for S. aureus bacteremia in Japan. Methods: From February 2011 to January 2014, we undertook a multicenter retrospective observational study in 10 departments of emergency and critical care in Japan...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29650263/-should-surgeons-keep-performing-drainage-after-breast-reduction
#3
N Vidali, A Chevet-Noel, P Ringenbach, J B Andreoletti
OBJECTIVE: Despite the absence of "evidence-based medicine", the use of closed suction drainage in breast surgery is currently the standard practice. Its goal is to minimize the amount of fluid at the operation site, the dead space that can involve postoperative complications. The purpose of this study is to demonstrate that with or without drainage the complication rate is unchanged. METHODS: We conducted a retrospective and comparative study of two groups of breast reduction with and without drainage...
April 9, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29644315/limb-salvage-and-reconstruction-following-a-zebra-attack
#4
Jacob T Carlson, James C Yuen, Matthew R Smeds
Animal bites are fairly rare events but can cause devastating traumatic injuries to the victim. In addition to the soft tissue, vascular, and orthopedic trauma inflicted by these occurrences, bite injuries also have the potential to introduce an inoculum of microbes, which may progress to an infection if not treated properly and expeditiously. We present the case of a healthy male who sustained multiple bite wounds from a domestic zebra to his left upper extremity. This attack caused severe damage, including devascularization of the arm at the brachial artery, disruption of the distal biceps and brachialis, stripping of the forearm nerves, and shearing of the overlying soft tissue...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29625989/a-cell-penetrating-peptide-fused-phage-lysin-kills-intracellular-mrsa-in-keratinocytes-and-treatment-for-skin-infections-of-mice
#5
ZhaoFei Wang, LiCheng Kong, Yang Liu, Qiang Fu, ZeLin Cui, Jian Wang, JingJiao Ma, HengAn Wang, YaXian Yan, JianHe Sun
Staphylococcus aureus ( S. aureus ) is the major pathogen that causes skin and skin structure infections, which is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multi-drug resistant bacteria, the use of phages and their lysins presents a promising alternative approach. In this study, a cell wall hydrolase (also called lysin) derived from Staphylococcus phage JD007, short for JDlys, was identified. The JDlys showed a strong lytic activity against MRSA strains from different sources and multilocus sequence typing (MLST) types...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29624209/withdrawn-grommets-ventilation-tubes-for-recurrent-acute-otitis-media-in-children
#6
REVIEW
Loretta Lau, Paul Mick, Desmond A Nunez
BACKGROUND: This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2008 and previously updated in 2011.Acute suppurative otitis media is one of the most common infectious diseases in childhood. Recurrent acute otitis media is defined for the purposes of this review as either three or more acute infections of the middle ear cleft in a six-month period, or at least four episodes in a year. Strategies for managing the condition include the assessment and modification of risk factors where possible, repeated courses of antibiotics for each new infection, antibiotic prophylaxis and the insertion of ventilation tubes (grommets)...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29619014/host-and-aquatic-environment-shape-the-amphibian-skin-microbiome-but-effects-on-downstream-resistance-to-the-pathogen-batrachochytrium-dendrobatidis-are-variable
#7
Andrea J Jani, Cheryl J Briggs
Symbiotic microbial communities play key roles in the health and development of their multicellular hosts. Understanding why microbial communities vary among different host species or individuals is an important step toward understanding the diversity and function of the microbiome. The amphibian skin microbiome may affect resistance to the fungal pathogen Batrachochytrium dendrobatidis (Bd). Still, the factors that determine the diversity and composition of the amphibian skin microbiome, and therefore may ultimately contribute to disease resistance, are not well understood...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29611491/defining-the-role-of-the-environment-in-the-emergence-and-persistence-of-vana-vancomycin-resistant-enterococcus-vre-in-an-intensive-care-unit-a-molecular-epidemiological-study
#8
Andie S Lee, Elizabeth White, Leigh G Monahan, Slade O Jensen, Raymond Chan, Sebastiaan J van Hal
OBJECTIVETo describe the transmission dynamics of the emergence and persistence of vanA vancomycin-resistant enterococcus (VRE) in an intensive care unit (ICU) using whole-genome sequencing of patient and environmental isolates.DESIGNRetrospective cohort study.SETTINGICU in a tertiary referral center.PARTICIPANTSPatients admitted to the ICU over an 11-month period.METHODS VanA VRE isolated from patients (n=31) were sequenced using the Illumina MiSeq platform. Environmental samples from bed spaces, equipment, and waste rooms were collected...
April 3, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29609860/prophylaxis-of-surgical-site-infection-in-adult-spine-surgery-a-systematic-review
#9
REVIEW
Reina Yao, Terence Tan, Jin Wee Tee, John Street
INTRODUCTION: Surgical site infection (SSI) remains a significant source of morbidity in spine surgery, with reported rates varying from 0.7 to 16%. OBJECTIVE: To systematically review and evaluate the evidence for strategies for prophylaxis of SSI in adult spine surgery in the last twenty years. METHODS: Two independent systematic searches were conducted, at two international spine centers, encompassing PubMed, ClinicalTrials.gov, Cochrane Database, EBSCO Medline, ScienceDirect, Ovid Medline, EMBASE (Ovid), and MEDLINE...
March 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29609530/high-frequency-of-m-leprae-dna-detection-in-asymptomatic-household-contacts
#10
Rafael Silva Gama, Thalisson Artur Ribeiro Gomides, Chaiana Fróes Magalhães Gama, Suelen Justo Maria Moreira, Fernanda Saloum de Neves Manta, Lorena Bruna P de Oliveira, Pedro Henrique Ferreira Marçal, Euzenir Nunes Sarno, Milton Ozório Moraes, Raúl Marcel González Garcia, Lucia Alves de Oliveira Fraga
BACKGROUND: Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical efficiency of quantitative PCR (qPCR) makes it a promising tool for early diagnosis of leprosy. Index cases that are multibacillary spread the bacillus silently, even before they are clinically diagnosed. Early detection and treatment could prevent transmission in endemic areas...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29608022/ivermectin-and-permethrin-for-treating-scabies
#11
REVIEW
Stefanie Rosumeck, Alexander Nast, Corinna Dressler
BACKGROUND: Scabies is an intensely itchy parasitic infection of the skin. It occurs worldwide, but is particularly problematic in areas of poor sanitation, overcrowding, and social disruption. In recent years, permethrin and ivermectin have become the most relevant treatment options for scabies. OBJECTIVES: To assess the efficacy and safety of topical permethrin and topical or systemic ivermectin for scabies in people of all ages. SEARCH METHODS: We searched the following databases up to 25 April 2017: the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, and IndMED...
April 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29606170/false-positive-tuberculin-skin-test-results-among-low-risk-healthcare-workers-following-implementation-of-fifty-dose-vials-of-purified-protein-derivative
#12
Jeffrey M Collins, Mary Hunter, Wanda Gordon, Russell R Kempker, Henry M Blumberg, Susan M Ray
Following large declines in tuberculosis transmission the United States, large-scale screening programs targeting low-risk healthcare workers are increasingly a source of false-positive results. We report a large cluster of presumed false-positive tuberculin skin test results in healthcare workers following a change to 50-dose vials of Tubersol tuberculin.Infect Control Hosp Epidemiol 2018;1-3.
April 2, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29600828/an-electrical-plasma-dissection-tool-for-surgical-treatment-of-chronic-ulcers-results-of-a-prospective-randomised-trial
#13
Giovanni F Marangi, Tiziano Pallara, Daniela Lamberti, Eleonora Perrella, Raffaele Serra, Francesco Stilo, Giovanni De Caridi, Andrea Onetti Muda, Paolo Persichetti
Cutaneous ulceration is a difficult medical problem and a major source of morbidity for patients. In the surgical treatment of ulcers, debridement is the first step, and it can be carried out using several surgical tools. Recently, new surgical devices have emerged using plasma-mediated electrical discharges with a lower peak temperature. A prospective single-blind trial was conducted on chronic ulcers not responsive to common non-surgical management. Patients were randomly separated into 2 groups: Group A received surgical debridement with conventional electrocautery, and Group B received surgical debridement using the plasma-mediated device...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29595103/application-of-medicinal-plants-as-a-source-for-therapeutic-agents-against-streptococcus-pyogenes-infections
#14
Adil Mohd, H P Vasantha Rupasinghe
Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis. This Gram-positive bacterium has an ability to form mature biofilm and this sessile lifestyle plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29594067/route-of-glucose-uptake-in-the-group-a-streptococcus-impacts-sls-mediated-hemolysis-and-survival-in-human-blood
#15
Ganesh S Sundar, Emrul Islam, Rezia D Braza, Aliyah B Silver, Yoann Le Breton, Kevin S McIver
The transport and metabolism of glucose has been shown to have far reaching consequences in the transcriptional profile of many bacteria. As glucose is most often the preferred carbon source for bacteria, its presence in the environment leads to the repression of many alternate carbohydrate pathways, a condition known as carbon catabolite repression (CCR). Additionally, the expression of many virulence factors is also dependent on the presence of glucose. Despite its importance, little is known about the transport routes of glucose in the human pathogen Streptococcus pyogenes ...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29577991/the-effect-of-an-exfoliating-skincare-regimen-on-the-numbers-of-epithelial-squames-on-the-skin-of-operating-theatre-staff-studied-by-surface-microscopy
#16
A G Wernham, O L Cain, A M Thomas
BACKGROUND: The shedding of epithelial squames (skin scales) by staff in operating theatre air is an important source for deep infection following joint replacement surgery. This is a serious complication resulting in significant morbidity for the patient and substantial cost implications for healthcare systems. Much effort has been put into providing clean-air in operating theatres, yet little attention has been given to reducing the shedding of surface skin scales at source. AIM: Our aim was to develop a novel method for calculating surface skin scale density using surface microscopy and to use it to evaluate the effect of a skin care regimen on operating theatre staff...
March 22, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29575271/oct-image-atlas-of-healthy-skin-on-sun-exposed-areas
#17
S O'Leary, A Fotouhi, D Turk, P Sriranga, A Rajabi-Estarabadi, K Nouri, S Daveluy, D Mehregan, M Nasiriavanaki
BACKGROUND: Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diagnosis of malignant melanoma could result in metastasis or death. Therefore, developing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infections, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins...
March 25, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29574997/fractional-ablative-carbon-dioxide-laser-followed-by-topical-sodium-stibogluconate-application-a-treatment-option-for-pediatric-cutaneous-leishmaniasis
#18
Yuval Hilerowicz, Amir Koren, Jacob Mashiah, Oren Katz, Eli Sprecher, Ofir Artzi
BACKGROUND: Leishmaniasis is a protozoan zoonotic parasitic infection with cutaneous, mucocutaneous, and visceral manifestations. Israel is endemic for cutaneous leishmaniasis, which is a self-limited disease but is associated with scarring, which is often a source of psychological and social burden for patients. Scars can be especially devastating for children and teenagers. A wide range of physical and medical approaches is used to treat cutaneous leishmaniasis, among which intralesional injections of sodium stibogluconate rank among the most frequently used...
March 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29570867/an-outbreak-of-microsporum-canis-infection-at-a-military-base-associated-with-stray-cat-exposure-and-person-to-person-transmission
#19
Tal Brosh-Nissimov, Ronen Ben-Ami, Nadav Astman, Alex Malin, Yaron Baruch, Inbal Galor
BACKGROUND: Tinea corporis caused by Microsporum canis is usually associated with exposure to animals, but outbreaks with anthropophilic transmission were described. A large outbreak in a military base was investigated. OBJECTIVES: To investigate the outbreak's source and risk factors for infection in order to contain and eliminate it. PATIENTS/METHODS: All staff-members at the base were interviewed and examined. A case-control analysis of symptomatic patients was used to elucidate risk factors...
March 23, 2018: Mycoses
https://www.readbyqxmd.com/read/29564998/biological-concepts-in-recurrent-plasmodium-vivax-malaria
#20
Miles B Markus
A curious aspect of the evolution of the hypnozoite theory of malarial relapse is its transmogrification from theory into 'fact', this being of historical, linguistic, scientific and sociological interest. As far as it goes, the hypnozoite explanation for relapse is almost certainly correct. I contend, however, that many of the genotypically homologous, non-reinfection, relapse-like Plasmodium vivax recurrences that researchers ascribe to hypnozoite activation are probably hypnozoite-independent. Indeed, some malariologists are starting to recognize that homologous P...
March 22, 2018: Parasitology
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