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Skin source infections

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https://www.readbyqxmd.com/read/27891222/epidemiology-of-klebsiella-pneumoniae-bloodstream-infections-in-a-teaching-hospital-factors-related-to-the-carbapenem-resistance-and-patient-mortality
#1
Lijun Tian, Ruoming Tan, Yang Chen, Jingyong Sun, Jialin Liu, Hongping Qu, Xiaoli Wang
BACKGROUND: Although Klebsiella pneumoniae bloodstream infections (KP-BSIs) have recently attracted attention due to an alarming raise in morbidity and mortality, there have been few reports on the epidemiology of KP-BSIs in mainland China. We sought to describe the epidemiological, microbiological, and clinical characteristics of KP-BSIs, focusing on the risk factors of carbapenem resistance and patient mortality. METHODS: A retrospective analysis of WHONET data of KP-BSI patients admitted to a teaching hospital in Shanghai, China, between January 1, 2011 and December 31, 2015 was performed, and the annual percentage of patients with carbapenem-resistant K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27891094/anti-acne-activity-of-italian-medicinal-plants-used-for-skin-infection
#2
Kate Nelson, James T Lyles, Tracy Li, Alessandro Saitta, Eugenia Addie-Noye, Paula Tyler, Cassandra L Quave
Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27885468/staphylococcus-lugdunensis-infections-filling-in-the-gaps-a-3-year-retrospective-review-from-a-comprehensive-cancer-center
#3
Lior Nesher, Jeffery Tarrand, Roy F Chemaly, Kenneth Vi Rolston
OBJECTIVE: Staphylococcus lugdunensis is considered to be more aggressive than other coagulase-negative staphylococci (CoNS). There are gaps in knowledge regarding the importance of isolating S. lugdunensis from different sources and in different patient subsets. Our objective was to describe the spectrum, clinical manifestations, and outcomes of infections caused by S. lugdunensis in patients with cancer. METHODS: A retrospective review of all cancer patients from whom S...
November 24, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27876971/isolation-of-acanthamoeba-spp-from-different-water-sources-in-isfahan-central-iran-2014
#4
Reza Mohammadi Manesh, Maryam Niyyati, Hossein Ali Yousefi, Abbas Ali Eskandarian
Acanthamoeba spp. are free-living amoeba found in a wide variety of natural habitats. The high percentage of the presence of Acanthamoeba in different environmental sources represents a sanitary risk for public health, especially immunocompromised patients and contact lens wearers. Acanthamoeba can cause granulomatous amoebic encephalitis, otitis, lung lesions, and skin infections in individuals with immune deficiencies. In the present study, the status of contamination of water sources in Isfahan, central Iran is analyzed through parasitological method...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876141/sers-as-an-analytical-tool-in-environmental-science-the-detection-of-sulfamethoxazole-in-the-nanomolar-range-by-applying-a-microfluidic-cartridge-setup
#5
Sophie Patze, Uwe Huebner, Falk Liebold, Karina Weber, Dana Cialla-May, Juergen Popp
Sulfamethoxazole (SMX) is a commonly applied antibiotic for treating urinary tract infections; however, allergic reactions and skin eczema are known side effects that are observed for all sulfonamides. Today, this molecule is present in drinking and surface water sources. The allowed concentration in tap water is 2·10(-7) mol L(-1). SMX could unintentionally be ingested by healthy people when drinking contaminated tap water, representing unnecessary drug intake. To assess the quality of tap water, fast, specific and sensitive detection methods are required, in which consequence measures for improving the purification of water might be initiated in the short term...
January 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27869623/contamination-of-the-surgical-field-with-propionibacterium-acnes-in-primary-shoulder-arthroplasty
#6
Travis M Falconer, Mohammed Baba, Lisa M Kruse, Oscar Dorrestijn, Matthew J Donaldson, Margaret M Smith, Melanie C Figtree, Bernard J Hudson, Benjamin Cass, Allan A Young
BACKGROUND: Propionibacterium acnes is a common pathogen identified in postoperative shoulder infection. It has been shown to be present in culture specimens during primary shoulder arthroplasty; however, recent work has suggested that it is most likely to be a contaminant. Our aim was to identify the potential sources of contamination in shoulder arthroplasty. METHODS: Tissue swabs were obtained for microbiological analysis from consecutive patients undergoing primary shoulder arthroplasty...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27864837/risk-factors-for-non-purulent-leg-cellulitis-a-systematic-review-and-meta-analysis
#7
REVIEW
M Quirke, F Ayoub, A McCabe, F Boland, B Smith, R O'Sullivan, A Wakai
Non-purulent cellulitis is an acute bacterial infection of the dermal and subdermal tissues that is not associated with purulent drainage, discharge or abscess. The objective of this systematic review and meta-analysis (SRMA) was to identify and appraise all controlled observational studies that have examined risk factors for the development of non-purulent cellulitis of the leg (NPLC). A systematic literature search of electronic databases and grey literature sources was performed in July 2015. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality of included studies...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27842758/characterisation-of-successive-acinetobacter-baumannii-isolates-from-a-deceased-haemophagocytic-lymphohistiocytosis-patient
#8
Hyeon Jin Choi, Min Cheol Kil, Ji-Young Choi, Sun Ju Kim, Ki-Sup Park, Yae-Jean Kim, Kwan Soo Ko
In this study, 38 Acinetobacter baumannii isolates successively isolated from blood, skin swabs and tracheal aspirates from a single patient who died from haemophagocytic lymphohistiocytosis were investigated. The isolates were collected between March 2012 and August 2012. A. baumannii genotypes were determined by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). In vitro antimicrobial susceptibility testing was performed and colistin heteroresistance and persistence were evaluated...
November 8, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27836205/effectiveness-of-cyanoacrylate-microbial-sealant-in-the-reduction-of-surgical-site-infection-in-gynecologic-oncology-procedures-a-phase-iii-single-institution-prospective-randomized-trial
#9
Eric D Thomas, Elizabeth K Nugent, Matthew C MacAllister, Katherine M Moxley, Lisa Landrum, Joan L Walker, D S McMeekin, Robert S Mannel, Gerald McGwin, Kathleen N Moore
OBJECTIVES: Surgery is a cornerstone for patients with gynecologic malignancies. Surgical site infections (SSI) remain a source of post-operative morbidity. Consequences range from escalated costs, delay in adjuvant therapy, and increased morbidity. Our primary objective was to evaluate the effectiveness of a cyanoacrylate microbial sealant (CMS) to reduce post-operative SSI following laparotomy for suspected gynecologic malignancy. METHODS: Patients were randomized using a 1:1 allocation to receive either standard skin preparation or standard preparation with CMS and stratified by BMI...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27829416/tyrosinase-inhibition-and-antioxidant-properties-of-asphodelus-microcarpus-extracts
#10
Amalia Di Petrillo, Ana Maria González-Paramás, Benedetta Era, Rosaria Medda, Francesca Pintus, Celestino Santos-Buelga, Antonella Fais
BACKGROUND: Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. microcarpus...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27824599/progression-to-tuberculosis-disease-increases-with-multiple-exposures
#11
Robyn S Lee, Jean-François Proulx, Dick Menzies, Marcel A Behr
During a single year, a Canadian village had 34 individuals with microbiologically confirmed tuberculosis (TB) among 169 people with a new infection (20%). A contact investigation revealed multiple exposures for each person. We investigated whether the intensity of exposure might contribute to this extraordinary risk of disease.We carried out a case-control study using a public health database. Among those with a new infection, 34 had culture-confirmed TB (cases) and 118 did not progress to disease (controls)...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27822524/from-sample-to-multi-omics-conclusions-in-under-48-hours
#12
Robert A Quinn, Jose A Navas-Molina, Embriette R Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J Minich, Alexey V Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C Dorrestein, Rob Knight
Multi-omics methods have greatly advanced our understanding of the biological organism and its microbial associates. However, they are not routinely used in clinical or industrial applications, due to the length of time required to generate and analyze omics data. Here, we applied a novel integrated omics pipeline for the analysis of human and environmental samples in under 48 h. Human subjects that ferment their own foods provided swab samples from skin, feces, oral cavity, fermented foods, and household surfaces to assess the impact of home food fermentation on their microbial and chemical ecology...
March 2016: MSystems
https://www.readbyqxmd.com/read/27809281/ph-dependent-antimicrobial-peptides-and-proteins-their-mechanisms-of-action-and-potential-as-therapeutic-agents
#13
REVIEW
Erum Malik, Sarah R Dennison, Frederick Harris, David A Phoenix
Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have been extensively investigated as a potential solution to the global problem of infectious diseases caused by pathogenic microbes. A group of AMPs that are increasingly being reported are those that utilise pH dependent antimicrobial mechanisms, and here we review research into this area. This review shows that these antimicrobial molecules are produced by a diverse spectrum of creatures, including vertebrates and invertebrates, and are primarily cationic, although a number of anionic examples are known...
November 1, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27798123/the-contribution-of-interleukin-2-to-effective-wound-healing
#14
Karen M Doersch, Daniel J DelloStritto, M Karen Newell-Rogers
Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment...
October 24, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27796621/fatal-disseminated-cowpox-virus-infection-in-an-adolescent-renal-transplant-recipient
#15
Paul Gazzani, Joanna E Gach, Isabel Colmenero, Jeff Martin, Hugh Morton, Kevin Brown, David V Milford
BACKGROUND: A 17-year-old boy on long-term immunosuppression following renal transplantation for chronic kidney disease (CKD), the result of dysplastic kidneys, initially presented with a swelling in his neck while attending hospital for an unrelated problem. A clinical diagnosis of tonsillitis was made, and he was treated with broad-spectrum antibiotics. Over a few days, his condition deteriorated, and he developed multiple vesicopustular skin lesions and required an emergency tonsillectomy due to respiratory distress...
October 28, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27788747/the-risk-of-bacterial-infection-after-tattooing
#16
Ralf Dieckmann, Ides Boone, Stefan O Brockmann, Jens A Hammerl, Annette Kolb-Mäurer, Matthias Goebeler, Andreas Luch, Sascha Al Dahouk
BACKGROUND: Tattooing is a globally growing trend. Overall prevalence among adults in industrialized countries is around 10-20%. Given the high and increasing numbers of tattooed people worldwide, medical and public health implications emerging from tattooing trends require greater attention not only by the public, but also by medical professionals and health policy makers. METHODS: We performed a systematic review of the literature on tattooassociated bacterial infections and bacterial contamination of tattoo inks...
October 7, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27777596/acmella-oleracea-and-achyrocline-satureioides-as-sources-of-natural-products-in-topical-wound-care
#17
Lais Thiemi Yamane, Eneida de Paula, Michelle Pedroza Jorge, Verônica Santana de Freitas-Blanco, Ílio Montanari Junior, Glyn Mara Figueira, Luís Adriano Anholeto, Patricia Rosa de Oliveira, Rodney Alexandre Ferreira Rodrigues
The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27761504/data-on-medicinal-plants-used-in-central-america-to-manage-diabetes-and-its-sequelae-skin-conditions-cardiovascular-disease-kidney-disease-urinary-problems-and-vision-loss
#18
Peter Giovannini, Melanie-Jayne R Howes, Sarah E Edwards
The data described in this article is related to the review article "Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: a review" (Giovannini et al., 2016) [1]. We searched publications on the useful plants of Central America in databases and journals by using selected relevant keywords. We then extracted reported uses of medicinal plants within the disease categories: diabetes mellitus, kidney disease, urinary problems, skin diseases and infections, cardiovascular disease, sexual dysfunction, vision loss, and nerve damage...
June 2016: Data in Brief
https://www.readbyqxmd.com/read/27760831/identification-of-the-causative-dermatophyte-of-tinea-capitis-in-children-attending-mbarara-regional-referral-hospital-in-uganda-by-pcr-elisa-and-comparison-with-conventional-mycological-diagnostic-methods
#19
Cornelia Wiegand, Peter Mugisha, Grace K Mulyowa, Peter Elsner, Uta-Christina Hipler, Yvonne Gräser, Silke Uhrlaß, Pietro Nenoff
Tinea capitis is a dermatophyte infection common among prepubertal children in sub-Saharan Africa and mainly caused by Trichophyton and Microsporum species. Accurate identification is challenging as conventional methods like culture and microscopy are slow and mostly based on morphological characteristics, which make them less sensitive and specific. Modern molecular methods, like polymerase chain reaction (PCR) assays, are gaining acceptance and are quick as well as accurate. The aim of this study was to investigate the clinical patterns of tinea capitis and to accurately identify the most common causative dermatophytes affecting the scalps of children aged 1 to 16 years attending the Skin Clinic at Mbarara University of Science and Technology (MUST), Mbarara, Uganda, East Africa, using both conventional mycological methods and PCR-ELISA for detection of dermatophyte DNA...
October 19, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27740540/domestic-shower-hose-biofilms-contain-fungal-species-capable-of-causing-opportunistic-infection
#20
John Moat, Athanasios Rizoulis, Graeme Fox, Mathew Upton
The domestic environment can be a source of pathogenic bacteria. We show here that domestic shower hoses may harbour potentially pathogenic bacteria and fungi. Well-developed biofilms were physically removed from the internal surface of shower hoses collected in four locations in England and Scotland. Amplicon pyrosequencing of 16S and 18S rRNA targets revealed the presence of common aquatic and environmental bacteria, including members of the Actinobacteria, Alphaproteobacteria, Bacteroidetes and non-tuberculous Mycobacteria...
October 2016: Journal of Water and Health
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