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Adenocarcinoma large bowel

Michael B Cook, Jennifer Drahos, Shannon Wood, Lindsey Enewold, Ruth Parsons, Neal D Freedman, Philip R Taylor, Winnie Ricker, Christian C Abnet
BACKGROUND: The absolute risk of oesophageal adenocarcinoma (EA) among individuals with Barrett's oesophagus (BE) is low and a majority of EA cases are diagnosed among individuals with no prior BE diagnosis. To ensure that insights from EA case-control studies are transferable to clinical management of BE populations, we conducted a case-case study to compare the clinical presentation, medical history and survival of EA cases with and without a prior BE diagnosis in the Surveillance, Epidemiology and End Results Medicare database...
October 25, 2016: British Journal of Cancer
Kenneth G Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig, Ramakrishna Battini
BACKGROUND: Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease. CASE PRESENTATION: A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. In 2009, he was diagnosed with stage IA lung adenocarcinoma and also noted to have worsening leukocytosis and thrombocytosis with peak platelet count of 1,054,000/mL)...
2016: Biomarker Research
Rohen White, Farshad Foroudi, Joseph Sia, Mary Ann Marr, Daryl Lim Joon
INTRODUCTION: No consensus exists regarding the optimal treatment setup for neoadjuvant radiotherapy of rectal cancer using a 3D conformal (3D CRT) technique. Positioning the patient prone with a belly board aims to reduce the amount of small bowel irradiated. METHODS: Twenty-five patients with locally advanced rectal cancer underwent computed tomography (CT) planning for neoadjuvant chemoradiotherapy. Patients were simulated prone with a belly board and then in the supine position...
July 28, 2016: Journal of Medical Radiation Sciences
Nicole Wieghard, Solange Mongoue-Tchokote, J Isaac Young, Brett C Sheppard, V Liana Tsikitis
AIM: Limited data exist on Crohn's disease (CD)-associated small bowel adenocarcinoma [SBA]. A large-scale retrospective cohort study was conducted comparing the clinical features and outcome of Crohn's-associated SBA and de novo SBA. METHOD: Data for patients with small bowel adenocarcinoma was gathered from the 1992 to 2010 United States Surveillance, Epidemiology and End Results cancer registry (SEER)-Medicare linked database. 2,123 patients were identified, of whom 179 had CD-associated and 1,944 de novo SBA...
September 22, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Francesca Rappa, Alessandro Pitruzzella, Antonella Marino Gammazza, Rosario Barone, Emanuele Mocciaro, Giovanni Tomasello, Francesco Carini, Felicia Farina, Giovanni Zummo, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello
Large bowel carcinogenesis involves accumulation of genetic alterations leading to transformation of normal mucosa into dysplasia and, lastly, adenocarcinoma. It is pertinent to elucidate the molecular changes occurring in the pre-neoplastic lesions to facilitate early diagnosis and treatment. Heat shock proteins (Hsps), many of which are molecular chaperones, are implicated in carcinogenesis, and their variations with tumor progression encourage their study as biomarkers. There are many reports on Hsps and cancer but none to our knowledge on their systematic quantification in pre-neoplastic lesions of the large bowel...
September 2016: Cell Stress & Chaperones
Emmanuel K Abudu, Oluyinka S Akinbami
Colorectal carcinomas (CRC) were initially thought to be rare in Africa including Nigeria, but recent studies have shown a reverse trend in our environment. This study is aimed to identify the clinical and pathological characteristics of CRC diagnosed between July 2006 and June 2015 in the University of Uyo Teaching Hospital, and a Private Specialist Laboratory, Uyo, Akwa Ibom State, Nigeria. All histological diagnosed cases of CRC seen in the two laboratories (University teaching and a private facility) in Uyo, Akwa-Ibom state, Nigeria during the study period were retrieved noting their bio-data, pathological and clinical variables...
June 28, 2016: Rare Tumors
Jana M Rocker, Marcus C Tan, Lee W Thompson, Carlo M Contreras, Jack A DiPalma, Lewis K Pannell
OBJECTIVES: There are currently no reliable, non-invasive screening tests for pancreatic ductal adenocarcinoma. The fluid secreted from the pancreatic ductal system ("pancreatic juice") has been well-studied as a potential source of cancer biomarkers. However, it is invasive to collect. We recently observed that the proteomic profile of intestinal effluent from the bowel in response to administration of an oral bowel preparation solution (also known as whole-gut lavage fluid, WGLF) contains large amounts of pancreas-derived proteins...
May 26, 2016: Clinical and Translational Gastroenterology
Seyed Mohammad Reza Nejatollahi, Omid Etemad
An intestinal obstruction occurs when either the small or large intestine is partly or completely blocked so it prevents passing the food or fluid through the small/large bowel. This blockage is due to the existence of a mechanical obstruction such as foreign material, mass, hernia, or volvulus. Common symptoms include cramping pain, nausea and vomiting, changes in bowel habits, inability to pass stool, and lack of gas. We present a case of an 83-year-old man who had been referred to Taleghani Hospital with symptoms of bowel obstruction...
2016: Case Reports in Surgery
Cornelius A Thiels, Nimesh D Naik, John R Bergquist, Blake A Spindler, Elizabeth B Habermann, Scott R Kelley, Bruce G Wolff, Kellie L Mathis
BACKGROUND: Synchronous colon cancers, defined as two or more primary colon cancer detected simultaneously at the time of initial diagnosis, account for up to 5% of all colon cancer diagnoses. Management principles and outcomes remain largely undefined. METHODS: A retrospective institutional review of patients undergoing curative intent resection for colon adenocarcinoma (Stages I-III) from 1995 to 2007 was performed. Hereditary causes or inflammatory bowel disease were excluded...
July 2016: Journal of Surgical Oncology
Mark Bettington, Ian S Brown, Christophe Rosty
Patients with serrated polyposis develop multiple serrated polyps throughout the large bowel: hyperplastic polyps (HP), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). The frequency and the characteristics of serrated lesions of the appendix have not been reported in serrated polyposis patients. We conducted a retrospective study of 34 serrated polyposis patients who underwent a total or right hemicolectomy for adenocarcinoma or polyp burden. An appendiceal serrated lesion was identified in 23 (68%): 13 SSAs, three SSAs with dysplasia, four HPs and three TSAs...
January 2016: Pathology
Benjamin Norton, Jemimah Denson, Christopher Briggs, Matthew Bowles, David Stell, Somaiah Aroori
Post-hepatectomy liver failure (PHLF) is a leading cause of morbidity and mortality following major liver resection. The development of PHLF is dependent on the volume of the remaining liver tissue and hepatocyte function. Without effective pre-operative assessment, patients with undiagnosed liver disease could be at increased risk of PHLF. We report a case of a 60-year-old male patient with PHLF secondary to undiagnosed alpha-1-antitrypsin deficiency (AATD) following major liver resection. He initially presented with acute large bowel obstruction secondary to a colorectal adenocarcinoma, which had metastasized to the liver...
March 21, 2016: World Journal of Gastroenterology: WJG
Adrian Kobe, Alberto Posabella, Athanasios Tampakis, Markus von Fluee, Martin Bolli
No abstract text is available yet for this article.
August 2016: International Journal of Colorectal Disease
Rasmus Dahlin Bojesen, Mikael Andersson, Lene Buhl Riis, Ole Haagen Nielsen, Tine Jess
BACKGROUND: Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994-2010. METHODS: The study population included all individuals aged 16 years or older living in Denmark during 1994-2010 (n = 7,070,142)...
September 2016: Journal of Gastroenterology
María Dolores Pérez Valderas, Óscar Nogales Rincón, Javier García Lledó, Leticia Pérez Carazo, Beatriz Merino Rodríguez, Ignacio Marín Jiménez, Cecilia González Asanza, Pedro Menchén Fernández-Pacheco
No abstract text is available yet for this article.
February 2016: Revista Española de Enfermedades Digestivas
A Arezzo, S Arolfo, M E Allaix, A Bullano, A Miegge, S Marola, M Morino
AIM: Transanal endoscopic microsurgery (TEM) was originally invented by Buess et al. (Chirurg, 1984, 55, 677-80) for the treatment of infraperitoneal rectal adenomas. Its indications have progressively expanded to include larger and more advanced lesions. The aim of the study was to report the results of TEM used for the treatment of circumferential rectal lesions. METHOD: We retrospectively reviewed the medical records of 17 consecutive patients [median age 69 (32-89) years; nine men] who underwent TEM for a circumferential rectal lesion in our department between September 2010 and January 2015...
September 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Anjie Yang, Jocelyn Brown, Ernie Mak
BACKGROUND: Neurolytic celiac plexus block is increasingly used to treat refractory pain associated with abdominal malignancies, especially pancreatic cancer. While self-limiting diarrhea can occur commonly in patients post procedure, a very rare risk of persistent diarrhea exists. OBJECTIVE: We present a case of a 70 year old female with locally advanced pancreatic adenocarcinoma who was hospitalized for persistent severe diarrhea post celiac plexus block and discuss management options for this adverse effect...
January 2016: Journal of Palliative Medicine
Cuneyt Kayaalp, Koray Kutluturk, Mehmet Ali Yagci, Mustafa Ates
AIM: To study the transcolonic extraction of the proximally resected colonic specimens by colonoscopic assistance at laparoscopic colonic surgery. METHODS: The diagnoses of our patients were Crohn's disease, carcinoid of appendix and adenocarcinoma of cecum. We preferred laparoscopic total mesocolic resections. Colon and terminal ileum were divided with endoscopic staplers. A colonoscope was placed per anal and moved proximally in the colon till to reach the colonic closed end under the laparoscopic guidance...
September 10, 2015: World Journal of Gastrointestinal Endoscopy
Carlo Calabrese, Paolo Gionchetti, Andrea Calafiore, Nico Pagano, Massimo Campieri, Fernando Rizzello
Intestinal tumors represent less than 6% of digestive tumors, and, because of the limitations of intestinal investigations, these tumors are difficult to diagnose. In this context, capsule endoscopy has proven effective, especially in patients with obscure digestive bleeding. In a large series of patients undergoing capsule endoscopy, small bowel tumors are found in 2.4-8.9% of cases. The aim of this retrospective, single-center study, based on prospective database, is to evaluate the frequency of small bowel tumors detected by capsule endoscopy in patients with occult gastrointestinal bleeding...
October 2015: Internal and Emergency Medicine
Zoltan Farkas Kispal, Daniel Kardos, Tamas Jilling, Laszlo Kereskai, Marla Isaacs, Daniel L Balogh, Andrew B Pinter, Holger Till, Peter Vajda
INTRODUCTION: Bladder augmentation is widely used to treat otherwise unmanageable urinary incontinence. However, it is associated with a large number of complications, of which tumor formation is the most severe. Mucin proteins and MUC genes are linked, among others, to malignancies of the urinary bladder and the gastrointestinal system. OBJECTIVE: To investigate histological alterations as well as changes in expression of MUC1 and MUC2 genes and proteins following different types of urinary bladder augmentation or substitution performed in children and adolescents...
December 2015: Journal of Pediatric Urology
Rossella Ponte, Luca Mastracci, Stefano Di Domenico, Carlotta Ferretti, Franco De Cian, Roberto Fiocca, Federica Grillo
BACKGROUND: Filiform polyposis (FP) is an uncommon cause of non-neoplastic and non-syndromic polyposis. Several hypotheses concerning its pathogenesis have been published. FP is most frequently associated with a post-inflammatory reparative process; indeed, the most frequent association is with inflammatory bowel disease (IBD). FP is characterized by one to hundreds of uniform, slender, arborizing, vermiform projections of the large bowel mucosa and submucosa lined by normal or inflamed colonic mucosa...
February 2015: Viszeralmedizin
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