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Pulmonary hypertension in CKD

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https://www.readbyqxmd.com/read/27881110/prevalence-of-chronic-kidney-disease-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#1
Swarna Gaddam, Sameer K Gunukula, James W Lohr, Pradeep Arora
BACKGROUND: The incidence and prevalence of chronic kidney disease (CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and cigarette smoking are well-recognized risk factors for CKD. Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation leading to airway obstruction and parenchymal lung destruction. Due to some of the common pathogenic mechanisms, COPD has been associated with increased prevalence of CKD. METHODS: Systematic review of medical literature reporting the incidence and prevalence of CKD in patients with COPD using the Cochrane Collaboration Methodology, and conduct meta-analysis to study the cumulative effect of the eligible studies...
November 24, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27795624/rifampicin-and-anti-hypertensive-drugs-in-chronic-kidney-disease-pharmacokinetic-interactions-and-their-clinical-impact
#2
A Agrawal, S K Agarwal, T Kaleekal, Y K Gupta
Patients on dialysis have an increased incidence of tuberculosis (TB). Rifampicin, a first-line antitubercular therapy (ATT) drug, is a potent inducer of hepatic cytochrome P450 (CYP). There is potential for pharmacokinetic interaction between rifampicin and anti-hypertensives that are CYP substrates: amlodipine and metoprolol. Therefore, hypertensive patients receiving rifampicin-based ATT are at risk for worsening of hypertension. However, this hypothesis has not yet been systematically studied. In this prospective study, hypertensive CKD 5D patients with TB were followed after rifampicin initiation...
September 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27782764/oleanane-derivatives-for-pharmaceutical-use-a-patent-review-2000-2016
#3
Milena Masullo, Cosimo Pizza, Sonia Piacente
Oleanolic acid has been considered a good start molecule for synthetic exploitation. Thus hundreds of oleanane triterpenoids have been synthesized and patented. Also many oleanane saponins have been patented for their biological activities and possible pharmaceutical use. Areas covered: Patents reporting the biological activities of oleanane derivatives and saponins with oleanane-type aglycones were examined. Among the synthesized oleanane derivatives, the most promising seem to be 2-cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid derivatives which interfere with many pathways involved in inflammation, oxidative stress and cell proliferation...
October 26, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27754194/br-05-2-angioplasty-of-atherosclerotic-renal-artery-stenosis-who-benefits
#4
Donghoon Choi
: Atherosclerotic renal artery stenosis is an increasingly recognized medical problem especially in elderly patients. It commonly occurs with systemic manifestations including hypertension (HTN), chronic kidney disease (CKD) or atherosclerotic diseases including coronary or peripheral artery disease. Significant renal artery stenosis may result in HTN, ischemic nephropathy, however it is still in debate about the benefit of revascularization. Although several randomized controlled trials including Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) and Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study has failed to reveal a significant benefit of angioplasty, angioplasty with medical therapy is increasingly accepted in some patients with certain clinical conditions...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27704317/the-addition-of-renal-sympathetic-denervation-to-pulmonary-vein-isolation-reduces-recurrence-of-paroxysmal-atrial-fibrillation-in-chronic-kidney-disease-patients
#5
Márcio Galindo Kiuchi, Shaojie Chen, Gustavo Ramalho E Silva, Luis Marcelo Rodrigues Paz, Tetsuaki Kiuchi, Ary Getulio de Paula Filho, Gladyston Luiz Lima Souto
BACKGROUND: Atrial fibrillation (AF) frequently complicates chronic kidney disease (CKD). AF treatment is challenging and requires complete pulmonary vein isolation (PVI). Recently, renal sympathetic denervation (RSD) has been reported to reduce AF recurrence when performed alongside PVI. METHODS: A prospective therapeutic study of patients with controlled hypertension and paroxysmal AF was undertaken. Renal function was evaluated using estimated glomerular filtration rate...
October 4, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27680887/why-is-your-patient-still-short-of-breath-understanding-the-complex-pathophysiology-of-dyspnea-in-chronic-kidney-disease
#6
Fabio Rosario Salerno, Grace Parraga, Christopher William McIntyre
Dyspnea is one of the most common symptoms associated with CKD. It has a profound influence on the quality of life of CKD patients, and its underlying causes are often associated with a negative prognosis. However, its pathophysiology is poorly understood. While hemodialysis may address fluid overload, it often does not significantly improve breathlessness, suggesting multiple and co-existing alternative issues exist. The aim of this article is to discuss the main pathophysiologic mechanisms and the most important putative etiologies underlying dyspnea in CKD patients...
September 28, 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27643151/br-05-2-angioplasty-of-atherosclerotic-renal-artery-stenosis-who-benefits
#7
Donghoon Choi
UNLABELLED: Atherosclerotic renal artery stenosis is an increasingly recognized medical problem especially in elderly patients. It commonly occurs with systemic manifestations including hypertension (HTN), chronic kidney disease (CKD) or atherosclerotic diseases including coronary or peripheral artery disease. Significant renal artery stenosis may result in HTN, ischemic nephropathy, however it is still in debate about the benefit of revascularization. Although several randomized controlled trials including Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) and Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study has failed to reveal a significant benefit of angioplasty, angioplasty with medical therapy is increasingly accepted in some patients with certain clinical conditions...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27459659/nephrotoxic-medication-exposure-in-u-s-adults-with-predialysis-chronic-kidney-disease-health-services-utilization-and-cost-outcomes
#8
Mary Lynn Davis-Ajami, Jeffery C Fink, Jun Wu
BACKGROUND: Nephrotoxic medication exposure increases risks for acute kidney injury, permanent renal function loss, and costly preventable adverse drug events. Exposure to medications associated with inducing acute tubular nephritis or tubular toxicity versus nonexposure among those with predialysis renal disease-a population vulnerable to increased risk of kidney injury-may affect health services utilization and cost outcomes. Few studies quantify nephrotoxic medication exposure in chronic kidney disease (CKD) and associated costs...
August 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27379919/impact-of-chronic-kidney-disease-on-clinical-outcomes-in-patients-with-non-st-elevation-myocardial-infarction-receiving-percutaneous-coronary-intervention-a-five-year-observational-study
#9
Hui-Ting Wang, Yung-Lung Chen, Chiung-Jen Wu
BACKGROUND: Patients with chronic kidney disease (CKD) experience poor outcomes after acute myocardial infarction. This study investigated how CKD affects clinical outcomes in patients with non-ST segment elevation myocardial infarction (NSTEMI) receiving PCI. METHODS: This retrospective study analyzed record-linked data for 314 patients who had received PCI for NSTEMI between January 2008 and September 2010. The 141 patients with advanced CKD were compared with 173 patients who had mild or no CKD...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27296259/-risk-factors-for-pulmonary-hypertension-at-the-predialysis-stage-of-chronic-kidney-disease
#10
T E Rudenko, M P Vasil'eva, N I Solomakhina, I M Kutyrina
AIM: To investigate the incidence and risk factors of pulmonary hypertension (PH) in patients with chronic kidney disease (CKD). SUBJECTS AND METHODS: 86 patients (53% men, 47% women; mean age, 45±13 years) with nondiabetic CKD were examined. According to the magnitude of glomerular filtration rate (GFR) decrease, all the patients were divided into 3 groups: 1) 33 patients with a GFR of 89--45 ml/min; 2) 33 with a GFR of 44--15 ml/min; 3) 20 with a GFR of <15 ml/min who were treated with hemodialysis...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27118234/soluble-guanylate-cyclase-stimulators-a-novel-treatment-option-for-heart-failure-associated-with-cardiorenal-syndromes
#11
REVIEW
Ruth F Dubin, Sanjiv J Shah
Heart failure in the setting of chronic kidney disease (CKD) is an increasingly common scenario and carries a poor prognosis. Clinicians lack tools for primary or secondary heart failure prevention in patients with cardiorenal syndromes. In patients without CKD, angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) and statins mitigate cardiovascular risk in large part due to salutary effects on the endothelium. In the setting of CKD, use of these therapies is limited by adverse effects of hyperkalemia in pre-dialysis CKD (ACE-I/ARB), or potential increased risk of stroke in end-stage renal disease (statins)...
June 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/26894597/hypoxia-inducible-factor-stabilizers-a-new-avenue-for-reducing-bp-while-helping-hemoglobin
#12
REVIEW
Farhanah Yousaf, Bruce Spinowitz
Anemia of chronic kidney disease (CKD) is common and is associated with diminished quality of life, cognitive impairment, cardiovascular morbidity, hospitalizations, and mortality. As the prevalence of end-stage renal disease continues to rise, the management of anemia represents a growing economic burden. Erythropoiesis-stimulating agents (ESA) are the mainstay of anemia management but their use is limited due to the associated cardiovascular adverse events. Prolyl hydroxylase domain enzyme (PHD) inhibitors are a new class of drugs that stabilize the hypoxia-inducible factors and are under clinical investigation for the treatment of renal anemia...
March 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/26891053/mortality-outcomes-of-patients-with-chronic-kidney-disease-and-chronic-obstructive-pulmonary-disease
#13
Sankar D Navaneethan, Jesse D Schold, Haiquan Huang, Georges Nakhoul, Stacey E Jolly, Susana Arrigain, Raed A Dweik, Joseph V Nally
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with higher mortality in the general population. We studied the associations between COPD and death among chronic kidney disease (CKD) patients along with reporting cause-specific death data. METHODS: We included 56,960 patients with stages 3 and 4 CKD who were followed in a large health care system. Associations between COPD and all-cause mortality and various causes of death (respiratory deaths, cardiovascular deaths, malignancy-related deaths and deaths due to other reasons) were studied using the Cox proportional hazards and competing risk models...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/26858715/macrophage-migration-inhibitory-factor-in-clinical-kidney-disease
#14
REVIEW
Annette Bruchfeld, Mårten Wendt, Edmund J Miller
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine implicated in acute and chronic inflammatory conditions, including sepsis, autoimmune disease, atherogenesis, plaque instability, and pulmonary arterial hypertension. MIF in plasma and urine is significantly elevated in patients with acute kidney injury (AKI) and elevated MIF in serum is associated with markers of oxidative stress, endothelial dysfunction, arterial stiffness, and markers of myocardial damage in chronic kidney disease (CKD)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26672999/use-of-calcium-channel-blockers-is-associated-with-mortality-in-patients-with-chronic-kidney-disease
#15
Dominik G Haider, Thomas Sauter, Gregor Lindner, Salome Masghati, Slobodan Peric, Alexander Friedl, Michael Wolzt, Walter H Hörl, Afschin Soleiman, Aristomenis Exadaktylos, Valentin Fuhrmann
BACKGROUND/AIMS: The use of antihypertensive medicines has been shown to reduce proteinuria, morbidity, and mortality in patients with chronic kidney disease (CKD). A specific recommendation for a class of antihypertensive drugs is not available in this population, despite the pharmacodynamic differences. We have therefore analysed the association between antihypertensive medicines and survival of patients with chronic kidney disease. METHODS: Out of 2687 consecutive patients undergoing kidney biopsy a cohort of 606 subjects with retrievable medical therapy was included into the analysis...
2015: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/26609681/pretransplant-echocardiographic-parameters-as-markers-of-posttransplant-outcomes-in-liver-transplant-recipients
#16
Daniel Bushyhead, James N Kirkpatrick, David Goldberg
Despite advances in liver transplantation and preoperative risk stratification, there remains significant posttransplant morbidity and mortality from cardiovascular and renal disease. There are limited and conflicting data on the role of pretransplant echocardiography to predict these outcomes. The purpose of our study was to determine if pretransplant echocardiographic parameters were associated with posttransplant survival and the development of incident cardiovascular events and chronic kidney disease (CKD)...
March 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26386072/prevalence-predictors-and-outcomes-of-pulmonary-hypertension-in-ckd
#17
MULTICENTER STUDY
Sankar D Navaneethan, Jason Roy, Kelvin Tao, Carolyn S Brecklin, Jing Chen, Rajat Deo, John M Flack, Akinlolu O Ojo, Theodore J Plappert, Dominic S Raj, Ghulam Saydain, James H Sondheimer, Ruchi Sood, Susan P Steigerwalt, Raymond R Townsend, Raed A Dweik, Mahboob Rahman
Pulmonary hypertension (PH) is associated with poor outcomes in the dialysis and general populations, but its effect in CKD is unclear. We evaluated the prevalence and predictors of PH measures and their associations with long-term clinical outcomes in patients with nondialysis-dependent CKD. Chronic Renal Insufficiency Cohort (CRIC) Study participants who had Doppler echocardiography performed were considered for inclusion. PH was defined as the presence of estimated pulmonary artery systolic pressure (PASP) >35 mmHg and/or tricuspid regurgitant velocity (TRV) >2...
March 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26386071/pulmonary-hypertension-in-ckd-some-answers-yet-more-questions
#18
EDITORIAL
Mark J Sarnak, Kari E Roberts
No abstract text is available yet for this article.
March 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26376386/preexisting-diabetes-and-risks-of-morbidity-and-mortality-after-gastrectomy-for-gastric-cancer-a-nationwide-database-study
#19
Ming-Shian Tsai, Yu-Chiao Wang, Yin-Hsien Kao, Long-Bin Jeng, Chia-Hung Kao
The purpose of this study was to determine the risk of surgical mortality and morbidity in patients with diabetes mellitus (DM) undergoing a gastrectomy for gastric cancer (GC). Using the Taiwan National Health Insurance Research Database, we identified 6284 patients who underwent gastrectomy for GC from 1999 to 2010. In addition, we created a non-DM control cohort consisting of 6268 patients who received gastrectomy during the same period. Compared with the non-DM cohort, the DM cohort exhibited a higher prevalence of preoperative coexisting medical conditions, namely hypertension, hyperlipidemia, coronary artery disease, chronic kidney disease, chronic pulmonary disease, stroke, and cirrhosis...
September 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26352407/genome-wide-association-study-with-targeted-and-non-targeted-nmr-metabolomics-identifies-15-novel-loci-of-urinary-human-metabolic-individuality
#20
Johannes Raffler, Nele Friedrich, Matthias Arnold, Tim Kacprowski, Rico Rueedi, Elisabeth Altmaier, Sven Bergmann, Kathrin Budde, Christian Gieger, Georg Homuth, Maik Pietzner, Werner Römisch-Margl, Konstantin Strauch, Henry Völzke, Melanie Waldenberger, Henri Wallaschofski, Matthias Nauck, Uwe Völker, Gabi Kastenmüller, Karsten Suhre
Genome-wide association studies with metabolic traits (mGWAS) uncovered many genetic variants that influence human metabolism. These genetically influenced metabotypes (GIMs) contribute to our metabolic individuality, our capacity to respond to environmental challenges, and our susceptibility to specific diseases. While metabolic homeostasis in blood is a well investigated topic in large mGWAS with over 150 known loci, metabolic detoxification through urinary excretion has only been addressed by few small mGWAS with only 11 associated loci so far...
September 2015: PLoS Genetics
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