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Endometrial cancer and biopsy

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https://www.readbyqxmd.com/read/29306233/vanishing-endometrial-carcinoma-in-hysterectomy-specimens-probable-implications-for-fertility-sparing-management
#1
Murat Öz, Alper Karalök, Levent Şirvan, Tolga Taşçı, Reyhan Öcalan, Ahmet Taner Turan, Tayfun Güngör, Mehmet Mutlu Meydanlı
Background/aim: The vanishing cancer phenomenon was first reported in radical prostatectomy specimens in the absence of neo-adjuvant treatment. Reported cases are mostly well-differentiated and low-volume tumors. A similar entity was described for hysterectomy specimens of patients with biopsy proven endometrial cancer (EC). In this study, we discuss the probable reasons for vanishing EC and long-term follow-up results of EC patients without residual tumors in hysterectomy specimens. Materials and methods: This study was carried at two institutions in Ankara, Turkey, in a retrospective design...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303931/prognostic-significance-of-omental-disease-and-the-role-of-omental-sampling-in-patients-with-uterine-carcinosarcoma
#2
Malcolm Strachan Ross, Esther Elishaev, Jessica Layne Berger, Joseph Leo Kelley, Sarah Elizabeth Taylor
OBJECTIVES: Uterine carcinosarcomas are an aggressive and rare form of endometrial cancer. Omentectomy is not part of routine staging, but biopsy is often done because omental disease is a known poor prognostic indicator. We sought to define the role of routine omental sampling during surgical staging. METHODS/MATERIALS: Patients who underwent staging for uterine carcinosarcoma at our institution from January 2000 to December 2013 were identified. Clinical and pathological data were abstracted...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29288227/endobronchial-metastasis-of-mixed-mullerian-tumour-of-the-uterus
#3
Vadsala Baskaran, Laura Pugh, Robert James Berg, John Anderson
Endobronchial metastasis occurs in only 2%-5% of non-pulmonary cancers. Here we report on an 84-year-old woman who presented with breathlessness and light-headedness while on holiday in Australia, 2 years post-treatment for endometrial cancer. Initial CT pulmonary angiogram identified a soft tissue mass in the left hemithorax. A chest radiograph performed after repatriation was consistent with a large left pleural effusion, but bedside ultrasound showed a lobulated mass involving the left hemidiaphragm. A pleural procedure in the traditional 'triangle of safety' would have resulted in inadvertent puncture of the underlying mass...
December 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29284899/myometrium-invasion-tumour-size-and-lymphovascular-invasion-as-a-prognostic-factor-in-dissemination-of-pelvic-lymphatics-at-endometrial-carcinoma
#4
Nenad Lucic, Dragica Draganovic, Sanja Sibincic, Vesna Ecim-Zlojutro, Snjezana Milicevic
Objective: The aim of this work is to show the importance of the depth of myometrium invasion, tumour size and lymphovascular invasion as prognostic factors in dissemination of lymphatic nodes at endometrial carcinoma (CE). Materials and methods: In the period from 2010 to 2015 at the University Clinic for Gynecology and Obstetrics in Banja Luka, 221 endometrial cancer surgeries were done (laparatomy 184-83%, laparascopy 37-16,74%). Patients who had uterus bleeding in peri/postmenopause or those whose endometrium thickness was bigger than 5 mm which was established by ultrasound, or those who had in their cavum uteri pathological (PH) diagnosis, underwent fractional curettage (FC) or hysteroscopy in order to obtain pathohistological endometrium diagnosis...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#5
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29247086/risk-of-high-grade-lesions-after-atypical-glandular-cells-in-cervical-screening-a-population-based-cohort-study
#6
Ingrid Norman, Anders Hjerpe, Joakim Dillner
OBJECTIVES: To determine how human papillomavirus (HPV) positivity of atypical glandular cells (AGCs) affects the predictive values for the presence of high-grade cervical lesions. DESIGN: Population-based cohort study. SETTING: Stockholm-Gotland region, Sweden. PARTICIPANTS: Between 17 February 2014 and 30 June 2016, there were 562 women with AGC detected in a cervical sample. Registry linkages up to 30 June 2016 identified 392 women with an associated HPV test and a histopathological follow-up...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29223698/risk-factors-for-unsuccessful-office-based-endometrial-biopsy-a-comparative-study-of-office-based-endometrial-biopsy-pipelle-and-diagnostic-dilation-and-curettage-d-c
#7
Bingying Xie, Cuifeng Qian, Bingyi Yang, Chengcheng Ning, Xiaoying Yao, Yan Du, Yue Shi, Xuezhen Luo, Xiaojun Chen
STUDY OBJECTIVE: To determine the risk factors for Pipelle diagnostic failure, which might help health care providers to choose the appropriate protocol for endometrial evaluation individually. DESIGN: A single-center prospective study (Canadian Task Force II) SETTING: The Obstetrics and Gynecology Hospital of Fudan University PATIENTS: 466 patients with an indication for endometrial biopsy INTERVENTIONS: All patients received Pipelle and then diagnostic dilation and curettage (D&C)...
December 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29194192/sentinel-node-biopsy-in-endometrial-cancer-with-dual-cervical-and-fundal-indocyanine-green-injection
#8
Ruben Ruiz, Mikel Gorostidi, Ibon Jaunarena, Constance Goiri, Justina Aguerre, Arantxa Lekuona
PURPOSE: The aim of this study was describe a novel sentinel lymph node (SLN) tracer injection procedure featuring dual cervical and fundal indocyanine green (ICG) injection for endometrial cancer and results of SLN biopsy. METHODS: Between June 26, 2014 and October 31, 2016, 111 patients underwent laparoscopic surgery for endometrial cancer at our institution. In all cases, we performed SLN biopsy with dual cervical and fundal ICG injection. All SLNs were processed with an ultrastaging technique...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29184876/feasibility-of-sentinel-lymph-node-dissection-using-tc-99m-phytate-in-papillary-thyroid-carcinoma
#9
Se Hyun Paek, Ka Hee Yi, Su-Jin Kim, June Young Choi, Kyu Eun Lee, Young Joo Park, Do-Joon Park, Keon Wook Kang, June-Key Chung
Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29173977/-european-guidelines-esmo-esgo-estro-consensus-conference-for-the-management-of-endometrial-cancer
#10
REVIEW
Marcos Ballester, Sofiane Bendifallah, Emile Daraï
Endometrial cancer (EC) is a major source of morbidity and mortality in women worldwide. In France, in 2015, EC was the first gynecological cancer in terms of incidence. Its prognosis is considered favorable because it is most often limited to the uterus at diagnosis. Nevertheless, it is a heterogeneous pathology and 5-year overall survival can vary from 92 % to 42 % in FIGO stage I depending on its histological characteristics. This great heterogeneity leads to important disparities in its surgical management as well as in indications for adjuvant therapies...
November 22, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29153060/using-pyruvate-kinase-as-a-predictor-for-patient-with-endometrial-cancer-having-complex-hyperplasia-with-atypia-to-prevent-hysterectomy-and-preserve-fertility-retrospective-immunohistochemical-study
#11
Susan Hosseini Nasab, Neda Jooya, Aryan Esmaeili, Neda Zarrin Khameh, Concepcion Diaz-Arrastia, Mazdak Momeni
OBJECTIVES: To explore whether the metabolic switches proceed or succeed the histological changes in precancerous lesions. To validate pyruvate kinase isoform 1 (PKM1) and pyruvate kinase isoform 2 (PKM2) as a histological biomarker to predict the progression of endometrial hyperplasia into invasive cancer status. METHODS: The records of 56 patients with a primary diagnosis of complex hyperplasia with atypia after endometrial biopsy were selected and analyzed retrospectively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#12
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid ((99m)Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29057431/is-routine-performance-of-the-uterine-cervix-canal-curettage-prior-to-the-curettage-of-the-uterine-cavity-justified
#13
Szymon Piątek, Jacek Lipa, Monika Górska, Katarzyna Malecha, Grzegorz Panek, Mirosław Wielgoś
OBJECTIVES: Endocervical curettage (ECC) together with the dilatation and curettage of the uterine cavity (D & C) is routinely performed in everyday clinical practice. The aim of this study is to assess the rationale of the performance of ECC prior to D & C in indications other than abnormal uterine bleeding (AUB). MATERIAL AND METHODS: Case histories of 736 patients after ECC performed in the 1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, were analyzed retrospectively, the indications for the procedure - age, menopausal status, parity, procedure operator's experience - as well as the result of the histopathology examination were taken into account...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29056441/use-of-a-novel-sentinel-lymph-node-mapping-algorithm-reduces-the-need-for-pelvic-lymphadenectomy-in-low-grade-endometrial-cancer
#14
Edward Tanner, Allison Puechl, Kimberly Levinson, Laura J Havrilesky, Abdulrahman Sinno, Angeles Alvarez Secord, Amanda N Fader, Paula S Lee
OBJECTIVES: To evaluate the capability of a novel sentinel lymph node (SLN) mapping algorithm to reduce the need for pelvic lymphadenectomy (PLND) in patients with low-grade (G1-2) endometrial cancer (LGEC). METHODS: Patients with LGEC underwent evaluation according to a novel lymphatic assessment algorithm during hysterectomy with SLN biopsy at two academic gynecologic oncology programs. Side-specific PLND was only performed if ipsilateral SLN mapping failed and high-risk uterine features were identified on frozen section (FS)...
October 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29050779/transcriptome-landscape-of-long-intergenic-non-coding-rnas-in-endometrial-cancer
#15
Bei Jun Chen, Frances L Byrne, Konii Takenaka, Susan C Modesitt, Ellen M Olzomer, James D Mills, Rhonda Farrell, Kyle L Hoehn, Michael Janitz
Endometrial cancer is the most common gynecological malignancy in the developed world. It is the fifth most common cancer and accounts for 4.8% of all cancers in women. Long intergenic non-coding RNAs (lincRNAs), a subclass of long non-coding RNAs, are pervasively transcribed throughout the human genome. OBJECTIVE: LincRNA expression patterns in endometrial cancer compared to normal healthy tissue are poorly characterised. In this study, the lincRNA transcriptome of endometrial cancers and adjacent normal endometrium from the same patients was sequenced and compared with transcriptomes of other gynaecologic malignancies including ovarian and cervical cancers...
October 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29038041/minilaparoscopy-vs-standard-laparoscopy-for-sentinel-node-dissection-a-pilot-study
#16
Stefano Uccella, Alessandro Buda, Chiara Morosi, Giampaolo Di Martino, Martina Delle Marchette, Claudio Reato, Jvan Casarin, Fabio Ghezzi
OBJECTIVE: To compare 3-mm minilaparoscopy and standard 5-mm laparoscopy for sentinel node (SLN) detection in apparent early stage endometrial cancer (EC). DESIGN: Retrospective study (Canadian Task Force II-2). SETTING: Two academic research centers. PATIENTS: Consecutive women with apparent early stage EC, who underwent surgical staging with SLN between November 2015 and April 2016. INTERVENTIONS: Total laparoscopic extrafascial hysterectomy + bilateral salpingo-oophorectomy and SLN attempt...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29031505/-histological-and-molecular-classification-of-endometrial-carcinoma-and-therapeutical-implications
#17
REVIEW
Catherine Genestie, Alexandra Leary, Mojgan Devassoux-Shisheboran, Aurélie Auguste
Endometrial cancer is the fourth cause of cancer in women in France and is the second most common cancer of the gynecologic cancer after breast cancer with 7275 new cases in 2012. The incidence of this neoplasm tends to increase with population aging, diabetes and obesity's augmentation. In rare cases, a hereditary factor has been described: Lynch's syndrome. The therapeutic management of the patient depends on the endometrial biopsy which specifies the histological type and the histo-prognostic grade as well as the MRI which allow the tumor staging...
October 12, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28986185/fertility-sparing-management-using-progestin-for-young-women-with-endometrial-cancer-from-a-population-based-study
#18
Soyoun Rachel Kim, Carlijn van der Zanden, Habibe Ikiz, Boris Kuzelijevic, Jon Havelock, Janice S Kwon
OBJECTIVE: For young women with complex atypical endometrial hyperplasia (CAH) and endometrial cancer (EC) who choose to preserve fertility, progestin therapy is the mainstay of treatment. The objective of this study was to evaluate oncologic and reproductive outcomes associated with progestin therapy among these women from a population-based cancer registry. METHODS: This was a retrospective population-based cohort study of women under age 45 in British Columbia from 2003 to 2015 with CAH or grade I endometrioid EC who used progestins as initial management...
October 3, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28954449/-clinical-analysis-of-76-cases-of-sentinel-lymph-node-detection-in-cervical-cancer-and-endometrial-cancer
#19
S C Liang, Z Q Wang, J L Wang
Objective: To evaluate the feasibility and clinical value of identifying sentinel lymph node (SLN) and to assess possible factors associated with detection rate in both cervical cancer and endometrial cancer. Methods: Retrospective study of 76 cases (39 with cervical cancer and 37 with endometrial cancer) were conducted in Peking University People's Hospital. All patients underwent SLN biopsy with tracers of indocyanine green (ICG) and (or) carbon nanoparticles. All mapped SLN was resected and followed by procedures that systematic pelvic lymphadenectomy and hysterectomy according to National Comprehensive Cancer Network (NCCN) guidelines...
September 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28949442/cervical-cancer-screening-cotesting-with-cytology-and-mrna-hpv-e6-e7-yields-high-rates-of-cin2-lesions-in-young-women
#20
Rosario Granados, Hilda Tellez-Safina, Isabel Solis, Francisco Mateos, Jose Maria Rodriguez-Barbero, Jose Antonio Aramburu, Miguel Angel Huertas, Paloma Bajo, Encarnacion Camarmo, Teresa Corrales, Pedro Medina, Beatriz Calvo, Esther Martin, Laura Anta, Manuel Zamora, Teresa Alcaide
BACKGROUND: European guidelines recommend primary HPV testing for cervical cancer screening. However, the starting age remains to be defined, with an undecided window between 30 and 35 years. This pilot study compares the effectiveness of primary HPV testing to that of cytology for the detection of high-grade (CIN2+) lesions stratified by age. METHODS: Cotesting with LBC cytology and APTIMA(®) HPV (AHPV) was performed in 5053 women aged 25-65 in an opportunistic screening program in Madrid...
September 26, 2017: Diagnostic Cytopathology
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