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Endometrial cancer and biopsy

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https://www.readbyqxmd.com/read/28213057/utilization-of-sentinel-lymph-node-biopsy-for-uterine-cancer
#1
Jason D Wright, Stephanie Cham, Ling Chen, William M Burke, June Y Hou, Ana I Tergas, Vrunda Desai, Jim C Hu, Cande V Ananth, Alfred I Neugut, Dawn L Hershman
BACKGROUND: To limit the potential short and long-term morbidity of lymphadenectomy, sentinel lymph node (SLN) biopsy has been proposed for endometrial cancer. The principle of SLN biopsy relies on removal of a small number of lymph nodes that are the first drainage basins from a tumor and thus the most likely to harbor tumor cells. While the procedure may reduce morbidity, efficacy data is limited and little is known about how commonly the procedure is performed. OBJECTIVE: We examined the patterns and predictors of use of SLN biopsy and outcomes of the procedure in women with endometrial cancer who underwent hysterectomy...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28187097/agreement-between-preoperative-endometrial-sampling-and-surgical-specimen-findings-in-endometrial-carcinoma
#2
Tiago Selbach Garcia, Márcia Appel, Raquel Rivero, Lúcia Kliemann, Maria Celeste Osório Wender
OBJECTIVES: The aims of the study were to evaluate agreement between preoperative endometrial samples and surgical specimens in endometrial carcinoma and to correlate this agreement with sample and patient characteristics. METHODS: Patients who received primary surgical treatment for endometrial carcinoma at a tertiary care center and had undergone preoperative endometrial sampling were included. Medical records were reviewed to collect information from pathology reports and data on patient characteristics...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28176325/sterol-regulatory-element-binding-protein-1-srebp1-gene-expression-is-similarly-increased-in-polycystic-ovary-syndrome-and-endometrial-cancer
#3
Mohamad Nasir Shafiee, Nigel Mongan, Claire Seedhouse, Caroline Chapman, Suha Deen, Jafaru Abu, William Atiomo
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid profiles. MATERIAL AND METHODS: A cross-sectional study was performed at Nottingham University Hospital, United Kingdom...
February 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#4
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28133142/-lynch-syndrome-caused-by-germline-alteration-of-mlh1-in-a-young-patient-who-developed-colon-and-endometrial-cancer-a-case-report
#5
Azusa Yamamoto, Okihide Suzuki, Noriyasu Chika, Tetsuya Ito, Yusuke Tajima, Kensuke Kumamoto, Hidetaka Eguchi, Youichi Kumagai, Keiichiro Ishibashi, Erito Mochiki, Yasushi Okazaki, Hideyuki Ishida
A 39-year-old woman underwent right colectomy for type-3 transverse colon cancer, which was histologically identified as well-differentiated stage II A adenocarcinoma with a mucinous component and tumor-infiltrating lymphocytes. The patient was suspected of having Lynch syndrome(LS)since she fulfilled 2 of the revised Bethesda criteria, even though there was no family history of LS. Twelve months after colectomy, abdominal CT revealed thickening of the uterine endometrium. Histopathological examination of biopsy specimens revealed well-differentiated endometrioid carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28118070/endometrial-cancer-with-congenital-uterine-anomalies-three-case-reports-and-a-literature-review
#6
Jinping Gao, Jintian Zhang, Wenyan Tian, Fei Teng, Huiying Zhang, Xuhong Zhang, Yingmei Wang, Fengxia Xue
: Background Uterine malformation is a rare deformity in woman, and only a few cases concerning endometrial cancer arising in patients with congenital uterine anomalies have been reported. Herein, we present three cases of endometrial cancer with different congenital uterine anomalies, and review studies involving congenital uterine anomalies associated with endometrial cancer in the past 25 years, in order to identify similarities and differences in clinicopathologic characteristics and prognosis between endometrial cancer associated with uterine anomalies, and normal uterus...
January 24, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28108938/preoperative-work-up-for-definition-of-lymph-node-risk-involvement-in-early-stage-endometrial-cancer-5-year-follow-up
#7
Pietro Cignini, Salvatore Giovanni Vitale, Antonio Simone Laganà, Antonio Biondi, Valentina Lucia La Rosa, Giuseppe Cutillo
This prospective cohort study aimed to analyze the accuracy of magnetic resonance imaging (MRI) and hysteroscopic excisional biopsy (HEB) for predicting the low- and high-risk patients with endometrial carcinoma for nodal involvement at preoperative evaluation. From January 2005 to December 2006, all patients with a diagnosis of endometrial carcinoma were prospectively included in the study and underwent pelvic MRI and HEB. The pelvic MRI (without contrast) was aimed to evaluate the extent of myometrial invasion (MI < 50%, MI ≥ 50%), the possible involvement of cervical stroma, the ovarian, and lymph nodes status...
January 20, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28072606/an-innovative-approach-using-simulation-to-teach-primary-care-gynecologic-procedures
#8
Susan D Hellier, Denise R Ramponi, Alexander Wrynn, Stephanie Garofalo
INTRODUCTION: In response to the growing body of evidence that simulation is a satisfactory way to instruct procedural skills, we developed an innovative model to teach common gynecologic procedures such as cervical cancer screening, cervical polyp removal, intrauterine device removal, and endometrial biopsy. The objectives of this study were to describe the construction of the model and to assess participants' satisfaction and confidence in applying the learning objectives to their clinical practice...
January 9, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28058558/call-for-surgical-nodal-staging-in-women-with-esmo-esgo-estro-high-intermediate-risk-endometrial-cancer-a-multicentre-cohort-analysis-from-the-francogyn-study-group
#9
L Ouldamer, S Bendifallah, G Body, G Canlorbe, C Touboul, O Graesslin, E Raimond, P Collinet, C Coutant, V Lavoué, J Lévêque, E Daraï, M Ballester
BACKGROUND: The European Society of Medical Oncology (ESMO)/European Society of Gynaecological Oncology (ESGO)/European Society for Radiotherapy & Oncology (ESTRO) classification for endometrial cancer (EC) now includes a high-intermediate risk (HIR) group of recurrence due to the adverse prognostic role of lymphovascular space involvement (LVSI) and grade 3 for women at intermediate risk. However, optimal surgical staging, and especially the place of lymphadenectomy, remains to be elucidated...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28057913/humoral-hypercalcemia-in-uterine-cancers-a-case-report-and-literature-review
#10
Vijeyaluxmy Motilal Nehru, Gwenalyn Garcia, Juan Ding, Fanyi Kong, Qun Dai
BACKGROUND Paraneoplastic hypercalcemia is a well-described complication associated with a variety of malignancies. However, its incidence in gynecological malignancies is low. CASE REPORT A 53-year-old woman presented with progressive abdominal distention and irregular vaginal bleeding of several weeks' duration. A contrast CT abdomen and pelvis was significant for a mass in the lower uterine/cervical region, multiple peritoneal and omental masses, enlarged pelvic and paraaortic lymph nodes, and large-volume ascites...
January 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/27999680/new-classification-of-endometrial-cancers-the-development-and-potential-applications-of-genomic-based-classification-in-research-and-clinical-care
#11
REVIEW
A Talhouk, J N McAlpine
Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed world. Classification of ECs by histomorphologic criteria has limited reproducibility and better tools are needed to distinguish these tumors and enable a subtype-specific approach to research and clinical care. Based on the Cancer Genome Atlas, two research teams have developed pragmatic molecular classifiers that identify four prognostically distinct molecular subgroups. These methods can be applied to diagnostic specimens (e...
2016: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/27993884/misdiagnosis-analysis-of-cervical-minimal-deviation-adenocarcinoma-a-report-of-three-rare-cases-and-literature-review
#12
REVIEW
Mingxing Sui, Yanling Pei, Dong Li, Qiaori Li, Peining Zhu, Tianmin Xu, Manhua Cui
Cervical minimal deviation adenocarcinoma (MDA) is a rare variant of cervical adenocarcinoma that is difficult to diagnose due to the deep location, endogenous growth pattern, deceptively benign appearance of tumor cells, and lack of connection to human papillomavirus (HPV). Cytological evaluation and biopsies offer suboptimal detection and transvaginal sonography or Magnetic Resonance Imaging (MRI) only reveal multiple lesions that mimic multiple benign nabothian cysts. Besides, standard screening, diagnostic tools, and treatments are not established...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27928858/carcinoma-of-the-lower-uterine-segment-diagnosed-with-lynch-syndrome-based-on-msh6-germline-mutation-a-case-report
#13
Masataka Adachi, Kouji Banno, Kenta Masuda, Megumi Yanokura, Moito Iijima, Takashi Takeda, Haruko Kunitomi, Yusuke Kobayashi, Wataru Yamagami, Akira Hirasawa, Kaori Kameyama, Kokichi Sugano, Daisuke Aoki
Endometrial cancer in the lower uterine segment (LUS) is associated with Lynch syndrome with MLH1 or MSH2 germline mutation. Here, we report a case of carcinoma of the LUS diagnosed with Lynch syndrome based on MSH6 germline mutation in a 46-year-old woman with abnormal vaginal bleeding. She had had rectal cancer at age 39 with a family history of colon cancer (father, 75 years), pancreatic cancer (paternal grandmother, 74 years), and colon cancer (maternal grandmother, 85 years). Magnetic resonance imaging showed a tumor in the LUS...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27910946/ki-67-in-endometrial-cancer-scoring-optimization-and-prognostic-relevance-for-window-studies
#14
Sarah Kitson, Vanitha N Sivalingam, James Bolton, Rhona McVey, Mashid Nickkho-Amiry, Melanie E Powell, Alexandra Leary, Hans W Nijman, Remi A Nout, Tjalling Bosse, Andrew G Renehan, Henry C Kitchener, Richard J Edmondson, Emma J Crosbie
Ki-67, a marker of cellular proliferation, is increasingly being used in pre-surgical window studies in endometrial cancer as a primary outcome measure. Unlike in breast cancer, however, there are no guidelines standardizing its measurement and its clinical relevance as a response biomarker is undetermined. It is, therefore, imperative that Ki-67 scoring protocols are optimized and its association with patient survival rigorously evaluated, in order to be able to clinically interpret the results of these studies...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27909879/investigating-vaginal-bleeding-in-postmenopausal-women-found-to-have-an-endometrial-thickness-of-equal-to-or-greater-than-10%C3%A2-mm-on-ultrasonography
#15
Hilary L Turnbull, Nikolaos Akrivos, Paul Simpson, Timothy J Duncan, Joaquin J Nieto, Nikolaos Burbos
PURPOSE: This aim of this study is to determine the risk of endometrial cancer in symptomatic postmenopausal women, when endometrial thickness on transvaginal ultrasonography is equal to or greater than 10 mm, and subsequent office-based endometrial sampling histology is negative. METHODS: This is a prospective cross-sectional study, performed in a gynaecological oncology centre in the United Kingdom between February 2008 and July 2012. All postmenopausal women presenting with vaginal bleeding were investigated using transvaginal ultrasonography...
December 1, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27865222/endometrial-tuberculosis-simulating-an-ovarian-cancer-a-case-report
#16
Silvia Eleonora Di Giovanni, Teresa Margarida Cunha, Ana Luisa Duarte, Ines Alves
Female genital tuberculosis remains a major health problem in developing countries and is an important cause of infertility. As symptoms, laboratory data and physical findings are non-specific, its diagnosis can be difficult. We describe a case of a 39-year-old woman suffering from peri-umbilical pain and increased abdominal size for one year, anorexia, asthenia, weight loss, occasionally dysuria and dyspareunia, and four months amenorrhea. Laboratory data revealed cancer antigen 125 (CA-125) level of 132.3 U/mL, erythrocyte sedimentation rate of 42 mm/h, and gamma-globulins of 2...
June 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27864117/microcystic-elongated-and-fragmented-melf-pattern-invasion-is-mainly-associated-with-isolated-tumor-cell-pattern-metastases-in-figo-grade-i-endometrioid-endometrial-cancer-eec
#17
Mathieu P Pelletier, Vincent Q Trinh, Philippe Stephenson, Anne-Marie Mes-Masson, Vanessa Samouelian, Diane M Provencher, Kurosh Rahimi
While many studies have evaluated the impact of mismatch repair protein loss of expression (MMR LOE) or microcystic, elongated and fragmented (MELF) pattern of myometrial invasion as individual factors in endometrial cancer, we analyzed the combined impact of both. We reviewed every case of FIGO grade 1 endometrioid endometrial cancers (EEC) from our institution, between 2011 and 2015, that had a sentinel lymph node biopsy and/or a lymphadenectomy, and examined the following data: age, myometrial infiltration, MELF infiltration, lymphovascular space invasion and lymph node status...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#18
COMPARATIVE STUDY
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
January 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27812854/sentinel-lymph-node-mapping-in-patients-with-stage-i-endometrial-carcinoma-a-focus-on-bilateral-mapping-identification-by-comparing-radiotracer-tc99-m-with-blue-dye-versus-indocyanine-green-fluorescent-dye
#19
Andrea Papadia, Ignacio Zapardiel, Beatrice Bussi, Fabio Ghezzi, Marcello Ceccaroni, Elena De Ponti, Federica Elisei, Sara Imboden, Begoña Diaz de la Noval, Maria Luisa Gasparri, Giampaolo Di Martino, Javier De Santiago, Michael Mueller, Francesca Vecchione, Federica Dell'Orto, Alessandro Buda
PURPOSE: The aim of this study was to compare technetium radiocolloid (Tc99(m)) + blue dye (BD) versus Indocyanine green (ICG) fluorescent dye in terms of the overall detection rate and bilateral sentinel lymph node (SLN) mapping in patients with endometrial carcinoma. METHODS: Patients from five European centers with apparently confined clinical stage I endometrial cancer were reviewed. A comparison was made between women who received SLN mapping with pelvic and/or aortic lymphadenectomy (LND), and women who underwent SLN algorithm (SA), was also performed between the two groups...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27803780/apoptosis-induction-of-human-endometriotic-epithelial-and-stromal-cells-by-noscapine
#20
Mohammad Rasoul Khazaei, Zahra Rashidi, Farzaneh Chobsaz, Mozafar Khazaei
OBJECTIVES: Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells in vitro. MATERIALS AND METHODS: In this in vitro study, endometrial biopsies from endometriosis patients (n=9) were prepared and digested by an enzymatic method (collagenase I, 2 mg/ml)...
September 2016: Iranian Journal of Basic Medical Sciences
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