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Degenerative disc disease

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https://www.readbyqxmd.com/read/28647468/influence-of-rabbit-notochordal-cells-on-symptomatic-intervertebral-disc-degeneration-anti-angiogenic-capacity-on-human-endothelial-cell-proliferation-under-hypoxia
#1
Woo-Keun Kwon, Hong Joo Moon, Taek-Hyun Kwon, Youn-Kwan Park, Joo Han Kim
OBJECTIVES: Symptomatic degenerative disc disease (DDD) is associated with neovascularization and nerve ingrowth into intervertebral discs (IVDs). Notochordal cells (NCs) are key cells that may lead to regeneration of IVDs. However, their activities under conditions of hypoxia, the real environment of IVD, are not well known. We hypothesized that NCs may inhibit neovascularization by interacting with endothelial cells (ECs) under hypoxia. DESIGN: Human IVDs were isolated and cultured to produce nucleus pulposus (NP) cell conditioned medium (NPCM)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28646343/clinical-outcome-following-anterior-cervical-discectomy-and-fusion-with-and-without-anterior-cervical-plating-for-the-treatment-of-cervical-disc-herniation-a-25-year-follow-up-study
#2
Benedikt W Burkhardt, Moritz Brielmaier, Karsten Schwerdtfeger, Joachim M Oertel
Extreme long-term clinical outcome studies following anterior cervical discectomy and fusion (ACDF) with an autologous iliac crest with and without Caspar plating (ACDF + CP) for the treatment of radiculopathy caused by cervical disc herniation (CDH) are extremely rare. Hospital records of patients who underwent ACDF or ACDF + CP for the treatment of CDH at least 17 years ago were reviewed. Information about diagnosis, surgery, pre- and postoperative clinical process, and repeated procedure was analyzed...
June 23, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28645219/pullulan-microbeads-si-hpmc-hydrogel-injectable-system-for-the-sustained-delivery-of-gdf-5-and-tgf-%C3%AE-1-new-insight-into-intervertebral-disc-regenerative-medicine
#3
Nina Henry, Johann Clouet, Audrey Fragale, Louise Griveau, Claire Chédeville, Joëlle Véziers, Pierre Weiss, Jean Le Bideau, Jérôme Guicheux, Catherine Le Visage
Discogenic low back pain is considered a major health concern and no etiological treatments are today available to tackle this disease. To clinically address this issue at early stages, there is a rising interest in the stimulation of local cells by in situ injection of growth factors targeting intervertebral disc (IVD) degenerative process. Despite encouraging safety and tolerability results in clinic, growth factors efficacy may be further improved. To this end, the use of a delivery system allowing a sustained release, while protecting growth factors from degradation appears of particular interest...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28640098/the-characteristics-of-stem-cells-in-human-degenerative-intervertebral-disc
#4
Lin Liang, Xuefeng Li, Dapeng Li, Weimin Jiang, Heng Wang, Jie Chen, Zhiyong Sun, Niannian Zhang, Yangyi Zhu
BACKGROUND: The aim of this study is to identify which possessed the best stem-cell-like characteristics in 3 kinds of cell in human degenerative intervertebral disc: NPSCs (nucleus pulposus-derived stem cells), AFSCs (annulus fibrosus-derived stem cells), or CESCs (cartilage endplate-derived stem cells). METHODS: We separated the disc samples obtained from 15 surgically treated patients with disc degenerative diseases into nucleus pulposus, annulus fibrosus, and cartilage endplate...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28632590/comparison-of-anterior-and-posterior-surgery-for-degenerative-cervical-myelopathy-an-mri-based-propensity-score-matched-analysis-using-data-from-the-prospective-multicenter-aospine-csm-north-america-and-international-studies
#5
So Kato, Aria Nouri, Dongjin Wu, Satoshi Nori, Lindsay Tetreault, Michael G Fehlings
BACKGROUND: Surgeons often choose between 2 different approaches (anterior and posterior) for surgical treatment of degenerative cervical myelopathy on the basis of imaging features of spinal cord compression, the number of levels affected, and the spinal alignment. However, there is a lack of consensus on which approach is preferable. The objective of the present study was to use magnetic resonance imaging (MRI)-based propensity-score-matched analysis to compare postoperative outcomes between the anterior and posterior surgical approaches for degenerative cervical myelopathy...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28623897/altered-somatosensory-profile-according-to-quantitative-sensory-testing-in-patients-with-degenerative-lumbar-spine-disorders-scheduled-for-surgery
#6
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott, Birgitta Öberg
BACKGROUND: Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to identify the proportion with altered somatosensory profile, and to analyze demographic characteristics, self-reported function, pain, and health pre- and 3 months post-surgery...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28608941/tgf-%C3%AE-stimulates-expression-of-chondroitin-polymerizing-factor-in-nucleus-pulposus-cells-through-the-smad3-rhoa-rock1-and-mapk-signaling-pathways
#7
Bo Hu, Chen Xu, Peng Cao, Ye Tian, Ying Zhang, Changgui Shi, Jun Xu, Wen Yuan, Huajiang Chen
The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the chondroitin sulfate backbone required for the synthesis of sulfated glycosaminoglycan (sGAG). Transforming growth factor beta (TGF-β) upregulates sGAG synthesis in nucleus pulposus cells; however, the mechanisms mediating this induction are incompletely understood. Our study demonstrated that ChPF expression was negatively correlated with the grade of degenerative intervertebral disc disease. Treatment of nucleus pulposus cells with TGF-β induced ChPF expression and enhanced Smad2/3, RhoA/ ROCK activation, and the JNK, p38 and ERK1/2 MAPK signaling pathways...
June 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#8
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28603572/fibroblast-transplantation-results-to-the-degenerated-rabbit-lumbar-intervertebral-discs
#9
Ibrahim Halil Ural, Kerem Alptekin, Aysegul Ketenci, Seyhun Solakoglu, Hasan Alpak, Süleyman Özyalçın
BACKGROUND: Our study is an analysis of the histological and radiological changes in degenerated lumbar intervertebral discs, after transplantation of fibroblasts in rabbits. With that study we aimed to show the viability of the fibroblasts injected to the degenerated discs, and observe their potential for further studies. METHOD: The apoptosis of the cell is one of the factors at the disc degeneration process. Fibroblasts may act as mesenchymal stem cells at the tissue to which they are injected and they may replace the apoptotic cells...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28600230/cytokine-and-chemokine-profile-changes-in-patients-with-lower-segment-lumbar-degenerative-spondylolisthesis
#10
Juraj Sutovsky, Martin Benco, Martina Sutovska, Michaela Kocmalova, Lenka Pappova, Juraj Miklusica, Andrej Frano, Egon Kurca
BACKGROUND: Lumbar degenerative spondylolisthesis (DS) develops as a result of inflammatory and remodeling processes in facet joints (FJs). Several inflammatory cytokines are involved in the osteoarthritic and remodeling changes that occur and in low-back and/or radicular pain, the most prevalent clinical symptom of disease. This study improves knowledge related to the roles that 27 cytokines, chemokines and growth factors play in the pathophysiology of lumbar DS. MATERIAL AND METHODS: Cytokine levels were examined using capture sandwich immunoassay using the Bio-Plex(®) 200 System and the Bio-PlexTM Human Cytokine Standard 27-Plex, Group I (Bio-Rad, Hercules, California, USA) separately in intervertebral discs (IVDs) and FJ bone tissue...
June 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28598895/the-concurrent-use-of-lumbar-total-disc-arthroplasty-and-anterior-lumbar-interbody-fusion-the-lumbar-hybrid-procedure-for-the-treatment-of-multi-level-symptomatic-degenerative-disc-disease-a-prospective-study
#11
Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen
STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes...
June 8, 2017: Spine
https://www.readbyqxmd.com/read/28586025/protective-role-of-17%C3%AE-estradiol-on-tumor-necrosis-factor-%C3%AE-induced-apoptosis-in-human-nucleus-pulposus-cells
#12
Huan Liu, Si-Dong Yang, Ying Xu, Sheng-Hua Ning, Tao Wang, Da-Long Yang, Wen-Yuan Ding
The molecular mechanisms underlying protection and pathogenesis in spinal degenerative diseases remain unclear. Tumor necrosis factor-α (TNF-α) has been demonstrated to induce apoptosis of inte rvertebral disc (IVD) cells during IVD degeneration, and 17β‑estradiol (17β‑E2) has a protective effect against IVD cell apoptosis. However, the underlying molecular mechanism by which 17β‑E2 protects nucleus pulposus (NP) cells remains to be investigated. The aim of the present study was to evaluate whether 17β‑E2 modulates apoptosis of human NP cells induced by TNF‑α...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28582418/an-in-vivo-comparison-study-in-goats-for-a-novel-motion-preserving-cervical-joint-system
#13
Jie Qin, Chenguang Zhao, Dong Wang, Bo Zhao, Jun Dong, Haopeng Li, Rongxia Sang, Shuang Wang, Jiao Fu, Rangrang Kong, Xijing He
Cervical degenerative disease is one of the most common spinal disorders worldwide, especially in older people. Anterior cervical corpectomy and fusion (ACCF) is a useful method for the surgical treatment of multi-level cervical degenerative disease. Anterior cervical disc replacement (ACDR) is considered as an alternative surgical method. However, both methods have drawbacks, particularly the neck motion decrease observed after arthrodesis, and arthroplasty should only be performed on patients presenting with cervical disc disease but without any vertebral body disease...
2017: PloS One
https://www.readbyqxmd.com/read/28575461/adjacent-segment-degeneration-after-anterior-cervical-discectomy-and-fusion-with-an-autologous-iliac-crest-graft-a-magnetic-resonance-imaging-study-of-59-patients-with-a-mean-follow-up-of-27%C3%A2-yr
#14
Benedikt W Burkhardt, Andreas Simgen, Gudrun Wagenpfeil, Wolfgang Reith, Joachim M Oertel
BACKGROUND: Anterior cervical decompression and fusion (ACDF) is a widely accepted surgical technique for the treatment of degenerative disc disease. ACDF is associated with adjacent segment degeneration (ASD). OBJECTIVE: To assess whether physiological aging of the spine would overcome ASD by comparing adjacent to adjoining segments more than 18 yr after ACDF. METHODS: Magnetic resonance imaging of 59 (36 male, 23 female) patients who underwent ACDF was performed to assess degeneration...
May 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28574978/adjacent-segment-degeneration-following-anterior-cervical-discectomy-and-fusion-versus-the-bryan-cervical-disc-arthroplasty
#15
Suo-Zhou Yan, Jun Di, Yong Shen
BACKGROUND Anterior cervical discectomy and fusion (ACDF) is an established treatment for degenerative disease of the cervical disc, but adjacent segment degeneration or instability may develop long term. The aim of this study was to investigate the risk factors for adjacent segment degeneration following ACDF compared with the use of the Bryan artificial disc for cervical disc arthroplasty (CDA). MATERIAL AND METHODS A prospective comparative study included 93 patients who underwent ACDF or CDA with the Bryan artificial cervical disc between 2002 and 2004, and who had more than eight years of follow-up...
June 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28560408/collagen-derived-n-acetylated-proline-glycine-proline-upregulates-the-expression-of-pro-inflammatory-cytokines-and-extracellular-matrix-proteases-in-nucleus-pulposus-cells-via-the-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#16
Chencheng Feng, Jinyue He, Yang Zhang, Minghong Lan, Minghui Yang, Huan Liu, Bo Huang, Yong Pan, Yue Zhou
N-acetylated proline-glycine-proline (N-Ac-PGP) is a chemokine involved in inflammatory diseases and is found to accumulate in degenerative discs. N-Ac-PGP has been demonstrated to have a pro-inflammatory effect on human cartilage endplate stem cells. However, the effect of N-Ac-PGP on human intervertebral disc cells, especially nucleus pulposus (NP) cells, remains unknown. The purpose of this study was to investigate the effect of N-Ac-PGP on the expression of pro-inflammatory factors and extracellular matrix (ECM) proteases in NP cells and the molecular mechanism underlying this effect...
May 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28559201/dysregulated-mir-127-5p-contributes-to-type-ii-collagen-degradation-by-targeting-matrix-metalloproteinase-13-in-human-intervertebral-disc-degeneration
#17
Wen-Bin Hua, Xing-Huo Wu, Yu-Kun Zhang, Yu Song, Ji Tu, Liang Kang, Kang-Cheng Zhao, Shuai Li, Kun Wang, Wei Liu, Zeng-Wu Shao, Shu-Hua Yang, Cao Yang
BACKGROUND: Intervertebral disc degeneration (IDD) is a chronic disease associated with the degradation of extracellular matrix (ECM). Matrix metalloproteinase (MMP)-13 is a major enzyme that mediates the degradation of ECM components. MMP-13 has been predicted to be a potential target of miR-127-5p. However, the exact function of miR-127-5p in IDD is still unclear. OBJECTIVE: We designed this study to evaluate the correlation between miR-127-5p level and the degeneration of human intervertebral discs and explore the potential mechanisms...
May 27, 2017: Biochimie
https://www.readbyqxmd.com/read/28559077/incidence-and-risk-factors-of-postoperative-adjacent-segment-degeneration-following-anterior-decompression-and-instrumented-fusion-for-degenerative-disorders-of-the-cervical-spine
#18
Hui Wang, Lei Ma, Dalong Yang, Sidong Yang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of postoperative adjacent segment degeneration following anterior decompression and instrumented fusion for degenerative disorders of the cervical spine, and hope to provide references in decision making and surgical planning for spinal surgeons. METHODS: By retrieving the medical records from January 2005 to September 2011, 283 patients were retrospectively reviewed. According to the occurrence of adjacent segment degeneration at follow up, patients were divided into two groups: ASD group and no ASD group...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28549000/a-comparison-of-anterior-and-posterior-lumbar-interbody-fusions-complications-readmissions-discharge-dispositions-and-costs
#19
Rabia Qureshi, Varun Puvanesarajah, Amit Jain, Adam L Shimer, Francis H Shen, Hamid Hassanzadeh
STUDY DESIGN: Retrospective Database Review OBJECTIVE.: To understand medical complication rates, readmission rates, costs and discharge dispositions in ALIFs versus TLIF/PLIFs for lumbar degenerative disease. SUMMARY OF BACKGROUND DATA: Indications for anterior (ALIFs) vs posterior lumbar interbody fusions (PLIFs) can vary, though benefits of anterior approach surgery include full access to the anterior column and ability to place fusion devices. METHODS: The PearlDiver Database of Medicare records was utilized for this retrospective database review...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28544701/intradiscal-application-of-a-pcla-peg-pcla-hydrogel-loaded-with-celecoxib-for-the-treatment-of-back-pain-in-canines-what-s-in-it-for-humans
#20
Anna R Tellegen, Nicole Willems, Martijn Beukers, Guy C M Grinwis, Saskia G M Plomp, Clemens Bos, Maarten van Dijk, Mike de Leeuw, Laura B Creemers, Marianna A Tryfonidou, Björn P Meij
Chronic low back pain is a common clinical problem in both the human and canine population. Current pharmaceutical treatment often consists of oral anti-inflammatory drugs to alleviate pain. Novel treatments for degenerative disc diseases focus on local application of sustained released drug formulations. The aim of this study was to determine safety and feasibility of intradiscal application of a PCLA-PEG-PCLA hydrogel releasing celecoxib, a COX-2 inhibitor. Biocompatibility was evaluated after subcutaneous injection in mice and safety of intradiscal injection of the hydrogel was evaluated in experimental dogs with early spontaneous intervertebral disc (IVD) degeneration...
May 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
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