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Degenerative disc disease

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https://www.readbyqxmd.com/read/28929036/factors-affecting-length-of-stay-following-elective-anterior-and-posterior-cervical-spine-surgery
#1
Frank J Yuk, Akbar Y Maniya, Jonathan J Rasouli, Alexa M Dessy, Patrick J McCormick, Tanvir F Choudhri
Background Disease of the cervical spine is widely prevalent, most commonly secondary to degenerative disc changes and spondylosis. Objective The goal of the paper was to identify a possible discrepancy regarding the length of stay (LOS) between the anterior and posterior approaches to elective cervical spine surgery and identify contributing factors. Methods A retrospective study was performed on 587 patients (341 anterior, 246 posterior) that underwent elective cervical spinal surgery between October 2001 and March 2014...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28927213/ten-step-minimally-invasive-spine-lumbar-decompression-and-dural-repair-through-tubular-retractors
#2
Mohamed Abdelatif Boukebir, Connor David Berlin, Rodrigo Navarro-Ramirez, Tim Heiland, Karsten Schöller, Cameron Rawanduzy, Sertaç Kirnaz, Ajit Jada, Roger Härtl
BACKGROUND: Minimally invasive spine (MIS) surgery utilizing tubular retractors has become an increasingly popular approach for decompression in the lumbar spine. However, a better understanding of appropriate indications, efficacious surgical techniques, limitations, and complication management is required to effectively teach the procedure and to facilitate the learning curve. OBJECTIVE: To describe our experience and recommendations regarding tubular surgery for lumbar disc herniations, foraminal compression with unilateral radiculopathy, lumbar spinal stenosis, synovial cysts, and dural repair...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28918116/atherosclerotic-disease-and-its-relationship-to-lumbar-degenerative-disc-disease-facet-arthritis-and-stenosis-with-computed-tomography-angiography
#3
William J Beckworth, John F Holbrook, Lisa G Foster, Laura A Ward, James R Welle
BACKGROUND: The intervertebral disc is the largest avascular structure in the body. It relies on passive diffusion from arteries at the periphery of the disc for nutrition. Prior studies have suggested a correlation between vascular disease and lumbar degenerative disc disease (DDD) but the association with facet arthritis and stenosis has not been evaluated. OBJECTIVE: To evaluate the degree of lumbar artery stenosis, aortic atherosclerosis on computed tomography angiography (CTAs) and its relationship to lumbar DDD, facet arthritis and spinal canal stenosis...
September 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28894792/influence-of-hla-matching-on-the-efficacy-of-allogeneic-mesenchymal-stromal-cell-therapies-for-osteoarthritis-and-degenerative-disc-disease
#4
Javier García-Sancho, Ana Sánchez, Aurelio Vega, David C Noriega, Mercedes Nocito
BACKGROUND: The necessity for more effective therapies for chronic osteoarticular diseases has led to the development of treatments based on mesenchymal stem cells (MSCs), the natural precursors of musculoskeletal tissue. Treatments with autologous MSCs yielded excellent results, with nearly 70% improvement of pain and disability in osteoarthritis and degenerative disc disease. Using allogeneic MSCs is logistically more convenient and would widen the pool of eligible patients, but potential immune rejection should be considered...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28894678/radiographic-risk-factors-of-reoperation-following-minimally-invasive-decompression-for-lumbar-canal-stenosis-associated-with-degenerative-scoliosis-and-spondylolisthesis
#5
Minori Kato, Takashi Namikawa, Akira Matsumura, Sadahiko Konishi, Hiroaki Nakamura
STUDY DESIGN: Prospective cohort study. OBJECTIVE: Microsurgical bilateral decompression via a unilateral approach (MBDU), a minimally invasive surgical (MIS) decompression method, has been performed for numerous degenerative lumbar diseases, including degenerative lumbar scoliosis (DLS) or degenerative spondylolisthesis (DS), at our institution. In this study, we evaluated the appropriateness of MBDU for DLS or DS patients. METHODS: A total of 207 patients treated by MBDU were included (88 women and 119 men; mean age, 70 [40-86] years)...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28894375/impact-of-t1-slope-on-surgical-and-adjacent-segment-degeneration-after-bryan-cervical-disc-arthroplasty
#6
Peng Yang, Yongqian Li, Jia Li, Yong Shen
BACKGROUND: This retrospective study investigated an association between preoperative T1 slope and surgical and adjacent segment degeneration (SASD) after Bryan cervical disc arthroplasty (BCDA) in patients with cervical degenerative disc disease. METHODS: Based on preoperative standing lateral radiographs, 90 patients were classified according to T1 slope that was higher or lower than the 50th percentile (high T1 or low T1, 28 and 62 patients, respectively). Patients were also classified as SASD or non-SASD (38 and 52 patients, respectively) determined by radiographs at final follow-up...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28890222/identifying-subsets-of-patients-with-single-level-degenerative-disc-disease-for-lumbar-fusion-the-value-of-prognostic-tests-in-surgical-decision-making
#7
Victor E Staartjes, Pieter-Paul A Vergroesen, Dick J Zeilstra, Marc L Schröder
BACKGROUND CONTEXT: Fusion surgery for degenerative disc disease (DDD) has become a standard of care, albeit not without controversy. Outcomes are inconsistent and a superiority over conservative treatment is debatable. Proper patient selection is key to clinical success, and a comprehensive understanding of prognostic tests does not currently exist. PURPOSE: To investigate the value of prognostic tests and sociodemographic factors in predicting outcomes following lumbar fusion surgery for DDD...
September 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28888674/geographical-variations-in-clinical-presentation-and-outcomes-of-decompressive-surgery-in-patients-with-symptomatic-degenerative-cervical-myelopathy-analysis-of-a-prospective-international-multicenter-cohort-study-of-757-patients
#8
Michael G Fehlings, Branko Kopjar, Ahmed Ibrahim, Lindsay A Tetreault, Paul M Arnold, Helton Defino, Shashank Sharad Kale, S Tim Yoon, Giuseppe M Barbagallo, Ronald H M Bartels, Qiang Zhou, Alexander R Vaccaro, Mehmet Zileli, Gamaliel Tan, Yasutsugu Yukawa, Darrel S Brodke, Christopher I Shaffrey, Osmar Santos de Moraes, Eric J Woodard, Massimo Scerrati, Masato Tanaka, Tomoaki Toyone, Rick C Sasso, Michael E Janssen, Ziya L Gokaslan, Manuel Alvarado, Ciaran Bolger, Christopher M Bono, Mark B Dekutoski
BACKGROUND CONTEXT: Degenerative cervical myelopathy (DCM) is a progressive degenerative spine disease and the most common cause of spinal cord impairment in adults worldwide. There is a paucity of studies reporting on regional variations in demographics, clinical presentation, disease causation and surgical effectiveness. PURPOSE: To evaluate differences in demographics, causative pathology, management strategies, surgical outcomes, length of hospital stay and complications across four geographic regions...
September 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28887690/cervical-sagittal-alignment-after-different-anterior-discectomy-procedures-for-single-level-cervical-degenerative-disc-disease-randomized-controlled-trial
#9
Roland D Donk, Hisse Arnts, Wim I M Verhagen, Hans Groenewoud, Andre Verbeek, Ronald H M A Bartels
BACKGROUND: The effect of anterior cervical discectomy without fusion (ACD), ACD with fusion by stand-alone cage (ACDF) or with arthroplasty (ACDA) on cervical sagittal alignment is not known and is the subject of this study. METHODS: A total of 142 adult patients with single-level cervical disease were at random allocated to different procedures: ACD (45), ACDF (47) and ACDA (50). Upright cervical spine radiographs were obtained. Angles of the involved angle and the angle between C2 and C7 were determined...
September 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28881110/endoscopic-spine-surgery
#10
REVIEW
Gun Choi, Chetan S Pophale, Bhupesh Patel, Priyank Uniyal
Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit degenerated disc segment and again with the discography it is possible to diagnose the pain generator and pathological degenerated disc very precisely and its treatment with minimally invasive approach...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28874973/inhibiting-vascular-endothelial-growth-factor-in-injured-intervertebral-discs-attenuates-pain-related-neuropeptide-expression-in-dorsal-root-ganglia-in-rats
#11
Jun Sato, Kazuhide Inage, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Masao Koda, Takeo Furuya, Junichi Nakamura, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori, Sumihisa Orita
STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia in a rat model. OVERVIEW OF LITERATURE: Increased expression of VEGF in degenerative disc disease increases the levels of inflammatory cytokines and nerve ingrowth into the damaged discs. In animal models, increased levels of VEGF can persist for up to 2 weeks after an injury...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28861198/lumbar-single-level-dynamic-stabilization-with-semi-rigid-and-full-dynamic-systems-a-retrospective-clinical-and-radiological-analysis-of-71-patients
#12
Ali Fahir Ozer, Tunc Oktenoglu, Emrah Egemen, Mehdi Sasani, Atilla Yilmaz, Deniz Ufuk Erbulut, Onur Yaman, Tuncer Suzer
BACKGROUND: This study compares the clinical and radiological results of three most commonly used dynamic stabilization systems in the field of orthopedic surgery. METHODS: A total of 71 patients underwent single-level posterior transpedicular dynamic stabilization between 2011 and 2014 due to lumbar degenerative disc disease. Three different dynamic systems used include: (1) the Dynesys system; (2) a dynamic screw with a PEEK rod; and (3) a full dynamic system (a dynamic screw with a dynamic rod; BalanC)...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28843706/variation-of-facet-joint-orientation-and-tropism-in-lumbar-degenerative-spondylolisthesis-and-disc-herniation-at-l4-l5-a-systematic-review-and-meta-analysis
#13
REVIEW
Ziyang Liu, Yuchen Duan, Xin Rong, Beiyu Wang, Hua Chen, Hao Liu
Although degenerative spondylolisthesis (DS) and lumber disc herniation (LDH) are common causes of back pain, the associations between the lumbar facet joint angle orientation and tropism in these conditions are still contentious. The objective of the meta-analysis was to identify the role of facet joint orientation and tropism on the development of lumbar degenerative disease, including DS and LDH. Electronic searches of PubMed and Embase were conducted up to April 2017. P value<0.05 was regarded as significant...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28816821/adjacent-segment-disease-after-cervical-spine-fusion-evaluation-of-a-70-patient-long-term-follow-up
#14
Mohamed Alhashash, Mootaz Shousha, Heinrich Boehm
STUDY DESIGN: A retrospective study of 70 patients undergoing surgical treatment for adjacent segment disease (ASD) after anterior cervical decompression and fusion (ACDF). OBJECTIVES: To analyze the risk factors for the development of ASD in patients who underwent ACDF. SUMMARY OF BACKGROUND DATA: ACDF has provided a high rate of clinical success for the cervical degenerative disc disease; nevertheless, adjacent segment degeneration has been reported as a complication at the adjacent level secondary to the rigid fixation...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28815167/response-to-objective-functional-testing-in-patients-with-lumbar-degenerative-disc-disease
#15
Kevin Phan, Ralph J Mobbs
No abstract text is available yet for this article.
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28815166/objective-functional-testing-in-patients-with-lumbar-degenerative-disc-disease
#16
Holger Joswig, Martin N Stienen, Nicolas R Smoll, Oliver P Gautschi
No abstract text is available yet for this article.
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28815162/clinical-application-of-ceramics-in-anterior-cervical-discectomy-and-fusion-a-review-and-update
#17
REVIEW
Shayan Abdollah Zadegan, Aidin Abedi, Seyed Behnam Jazayeri, Hirbod Nasiri Bonaki, Alexander R Vaccaro, Vafa Rahimi-Movaghar
STUDY DESIGN: Narrative review. OBJECTIVES: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited availability and donor site morbidities have led to a constant search for new materials. Clinically, it has been shown that calcium phosphate ceramics, including hydroxyapatite (HA) and tricalcium phosphate (TCP), are effective as osteoconductive materials and bone grafts...
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811990/clinical-outcomes-of-total-disc-replacement-versus-anterior-lumbar-interbody-fusion-for-surgical-treatment-of-lumbar-degenerative-disc-disease
#18
Tobias A Mattei, Jennifer Beer, Alisson R Teles, Azeem A Rehman, Jean Aldag, Dzung Dinh
STUDY DESIGN: The authors performed a retrospective controlled study of patients diagnosed with lumbar degenerative disc disease who received surgical intervention (either total disc replacement [TDR]/Activ-L or anterior lumbar interbody fusion [ALIF]) at a single tertiary-care hospital from 2007-2010. OBJECTIVES: To investigate the clinical outcomes after TDR in comparison with ALIF for surgical treatment of lumbar degenerative disc disease (DDD). METHODS: Analyzed data included intra-operative blood loss, time to return to work, and clinical outcomes as evaluated through the Oswestry Disability Index (ODI) and the Visual Analog Scale (VAS) pain questionnaires pre-operatively and at 6 weeks, 3 months, 6 months, and 1 year postoperative follow-up...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28803345/substantial-clinical-benefit-for-neck-disability-index-revisited-establishing-the-goal-for-treatment
#19
Roland D Donk, Andre L M Verbeek, Wim I M Verhagen, Hans Groenewoud, Allard T F Hosman, Ronald H M A Bartels
PURPOSE: It is difficult for clinicians to inform patients about the success rate of a treatment as a cervical anterior discectomy procedure. Ideally, a proportion of good outcome as rated by patients is known. Patient-reported outcome measurements are helpful. The purpose is to relate the difference in Neck Disability Index (NDI) after a cervical anterior discectomy procedure for single level cervical degenerative disc disease with the patients' rating of their actual clinical situation after long-term follow-up to define the substantial clinical benefit (SCB)...
August 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28797605/space-available-for-cord-motion-and-disc-degeneration-at-the-adjacent-segments-level-of-degenerative-cervical-spondylolisthesis-using-kinematic-mri
#20
Permsak Paholpak, Alexander Nazareth, Kaku Barkoh, Larry V Lee, Joshua Lucas, Zorica Buser, Jeffrey C Wang
The objective was to evaluate motion, disc degeneration and Space Available for Cord (SAC) at the adjacent segments of degenerative cervical spondylolisthesis (DCS) using kinematic Magnetic Resonance Imaging (kMRI). The cervical spine kMRI of sixty-one DCS spinal levels (38 anterolisthesis and 23 retrolisthesis) were analyzed at the listhesis level and its adjacent segments in three position using kMRI. MRAnalyzer3 was used to analyze translation, angular motion and SAC. The caudad level had significantly less translation motion than the listhesis level in overall DCS or grade 2 anterolisthesis group (P<0...
August 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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