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Degenerative disc disease

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https://www.readbyqxmd.com/read/29322911/comparison-of-lumbar-pedicular-dynamic-stabilisation-systems-versus-fusion-for-the-treatment-of-lumbar-degenerative-disc-disease-a-meta-analysis
#1
Y-J Huang, S-J Zhao, Q Zhang, L-M Nong, N-W Xu
This study aimed to systematically compare the safety, effectiveness and radiological changes after lumbar pedicular dynamic stabilisation systems and fusion to treat lumbar degenerative disc disease . All studies that were performed to compare various lumbar pedicular dynamic stabilisation systems with any lumbar fusion to treat lumbar degenerative disc disease and were published until April 30, 2015 were acquired through a comprehensive search in various databases. A meta-analysis was performed after the methodological qualities of trials were assessed and after data were extracted...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29322313/implantation-of-an-empty-polyetheretherketone-cage-in-anterior-cervical-discectomy-and-fusion-a-prospective-randomised-controlled-study-with-2%C3%A2-years-follow-up
#2
Shang-Wen Feng, Ming-Chau Chang, Po-Hsin Chou, Hsi-Hsien Lin, Shih-Tien Wang, Chien-Lin Liu
PURPOSE: To compare the clinical outcomes, radiographic results and fusion rate of ACDF between empty PEEK cages and PEEK cages packed with β-tricalcium phosphate. METHODS: Forty-five patients were prospectively enrolled with cervical degenerative disc disease who requiring ACDF with a PEEK cage. 23 patients were randomised to the study group (empty cages) and 22 patients were in the control group (cages filled with β-tricalcium phosphate). Both patient groups were fixed with a cervical locking plate...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29320615/an-intervertebral-disc-whole-organ-culture-system-to-investigate-proinflammatory-and-degenerative-disc-disease-condition
#3
Gernot Lang, Yishan Liu, Janna Geries, Zhiyu Zhou, David Kubosch, Norbert Südkamp, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li
OBJECTIVE: The aim of this study was to compare the effect of different disease initiators of degenerative disc disease (DDD) within an intervertebral disc (IVD) organ culture system, and to understand the interplay between inflammation and degeneration in the early stage of DDD. DESIGN: Bovine caudal IVDs were cultured within a bioreactor for up to 11 days. Control group was cultured under physiological loading (0.02-0.2 MPa; 0.2 Hz; 2h/day) and high glucose (4...
January 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29315119/cervical-artificial-disc-replacement-with-discover-prosthesis-does-not-reduce-the-midterm-risk-of-heterotopic-ossification-results-of-a-cohort-study
#4
Jinhao Miao, Ye Shen, Chao Li, Lei Fang, Lei Zhang, Xiangyi Zhang, Yiman Li, Yong Kuang
STUDY DESIGN: A prospective cohort study with 79 patients. OBJECTIVE: To analyze the midterm incidence of heterotopic ossification (HO) after cervical artificial disc replacement with Discover prosthesis in treatment of cervical degenerative disc disease. MATERIALS AND METHODS: A cohort of 79 patients with 102 Discover prostheses (56 monosegment and 23 bisegments) was evaluated. Clinical and radiographic follow-up was performed. The performance of HO of the operative segments was assessed annually after the operation for 4 years...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29312639/progranulin-derived-engineered-protein-atsttrin-suppresses-tnf-%C3%AE-mediated-inflammation-in-intervertebral-disc-degenerative-disease
#5
Hong Ding, Jianlu Wei, Yunpeng Zhao, Yi Liu, Lian Liu, Lei Cheng
Atsttrin, an engineered molecule composed of three fragments of progranulin(PGRN), exerts comparable anti-inflammation ability. Intervertebral disc degeneration (IDD) is involved in inflammation in which TNF-α plays a key role. This study aims to examine the effect and the mechanism of Atsttrin in the pathogenesis of intervertebral disc degeneration. For this purpose, we took advantage of murine and human intervertebral disc (IVD) and examined the expression of TNF-α in IVD tissues using immunohistochemistry and TNF-α level in peripheral sera by ELISA assay...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310920/total-hip-arthroplasty-patients-with-fixed-spinopelvic-alignment-are-at-higher-risk-of-hip-dislocation
#6
Christina I Esposito, Kaitlin M Carroll, Peter K Sculco, Douglas E Padgett, Seth A Jerabek, David J Mayman
BACKGROUND: Sitting radiographs have been used as a pre-operative tool to plan patient-specific total hip arthroplasty (THA) component position that would improve hip stability. Previous work has demonstrated that spinal mobility may impact functional acetabular position when seated. We sought to determine whether patients who dislocate following THA have different sitting spinopelvic alignment or acetabular component orientation compared to patients who did not dislocate. METHODS: A consecutive series of 1000 patients underwent post-operative low-dose biplanar spine-to-ankle lateral radiographs in standing and sitting positions 1 year following THA...
December 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29288377/outcomes-of-the-bryan-cervical-disc-replacement-fifteen-year-follow-up
#7
Vincent Pointillart, Jean-Etienne Castelain, Pierre Coudert, Derek Thomas Cawley, Olivier Gille, Jean-Marc Vital
BACKGROUND: The CTDR is a technique that treats cervical disc degenerative disease. Initial shorter-term studies showed good clinical and radiological results. PURPOSE: To assess the clinical and radiological results of Bryan cervical disc replacement (Medtronic Sofamor Danek Inc., Memphis, TN) at 15-year follow-up. RESULTS: This prospective study included 20 patients who underwent 22 CTDR, comprising a single-level procedure in 14 patients and two-level procedures in six patients...
December 29, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29286093/identifying-hub-genes-and-potential-mechanisms-associated-with-senescence-in-human-annulus-cells-by-gene-expression-profiling-and-bioinformatics-analysis
#8
Chao Liu, Nong Chen, Kai Huang, Minbo Jiang, He Liang, Zhongyi Sun, Jiwei Tian, Deguo Wang
The aim of the present study was to reveal the potential hub genes and regulatory mechanisms associated with senescence in human annulus cells by analyzing microarray data using bioinformatics. The gene expression dataset GSE17077, of senescent and non‑senescent annulus cells obtained from patients with disc degenerative diseases (DDD), was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified. Functional and pathway annotations were performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes terms, respectively...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29284234/chemometric-evaluation-of-concentrations-of-trace-elements-in-intervertebral-disc-tissue-in-patient-with-degenerative-disc-disease
#9
Łukasz Kubaszewski, Anetta Zioła-Frankowska, Zuzanna Gasik, Marcin Frankowski, Mikołaj Dąbrowski, Bartłomiej Molisak, Jacek Kaczmarczyk, Robert Gasik
BACKGROUND: The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fully understood. Trace elements are the basic components of the biological compound related both its metabolism as well as environmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of the disease. MATERIAL AND METHODS: We have analysed trace elements content in the 30 intervertebral disc from 22 patients with degenerative disc disease...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29283093/anterior-cervical-disc-fusion-does-not-affect-the-presence-of-cervical-vestibular-evoked-myogenic-potential
#10
Ioannis Kastanioudakis, Panagiotis Saravakos, Andreas Zigouris, Vasileios Ragos, Oliver Reichel, Nafsika Ziavra
OBJECTIVE: Cervical spondylosis and cervical disk herniation are the most frequent forms of degenerative disease in the cervical spine. Surgical treatment mainly includes anterior cervical disk fusion. However, information concerning vestibular-evoked myogenic potential (VEMP) recording in patients undergoing cervical spine surgery is limited. The present prospective study aimed to investigate the effect of anterior disk fusion surgery on cervical VEMP (cVEMP) parameters. MATERIALS AND METHODS: Twenty-five patients were enrolled in this study, and 20 patients (10 men and 10 women) completed cVEMP testing...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29279773/automatic-cdr-estimation-for-early-glaucoma-diagnosis
#11
M A Fernandez-Granero, A Sarmiento, D Sanchez-Morillo, S Jiménez, P Alemany, I Fondón
Glaucoma is a degenerative disease that constitutes the second cause of blindness in developed countries. Although it cannot be cured, its progression can be prevented through early diagnosis. In this paper, we propose a new algorithm for automatic glaucoma diagnosis based on retinal colour images. We focus on capturing the inherent colour changes of optic disc (OD) and cup borders by computing several colour derivatives in CIE L∗a∗b∗ colour space with CIE94 colour distance. In addition, we consider spatial information retaining these colour derivatives and the original CIE L∗a∗b∗ values of the pixel and adding other characteristics such as its distance to the OD centre...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29279739/evaluation-of-two-novel-integrated-stand-alone-spacer-designs-compared-with-anterior-and-anterior-posterior-single-level-lumbar-fusion-techniques-an-in-vitro-biomechanical-investigation
#12
Craig A Kuhns, Jonathan A Harris, Mir M Hussain, Aditya Muzumdar, Brandon S Bucklen, Saif Khalil
Study Design: In vitro biomechanical investigation. Purpose: To compare the biomechanics of integrated three-screw and four-screw anterior interbody spacer devices and traditional techniques for treatment of degenerative disc disease. Overview of Literature: Biomechanical literature describes investigations of operative techniques and integrated devices with four dual-stacked, diverging interbody screws; four alternating, converging screws through a polyether-ether-ketone (PEEK) spacer; and four converging screws threaded within the PEEK spacer...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29274453/comparative-cohort-study-of-non-navigated-versus-navigated-percutaneous-pedicle-screw-implantation-in-patients-undergoing-surgery-for-degenerative-lumbar-disc-disease
#13
Edward Fomekong, Julien Pierrard, Christian Raftopoulos
BACKGROUND/OBJECTIVE: The major limitation of computer-based 3D fluoroscopy is the increased radiation exposure of patients and the operating room (OR) staff. Adjunction of spine navigation to intraoperative 3D fluoroscopy (io3DF) can likely overcome this shortcoming while increasing the pedicle screw accuracy rate. Thus, we compared data from a cohort of patients undergoing lumbar percutaneous pedicle screw (PPS) placement utilizing io3DF alone or in combination with spine navigation...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29274450/does-obesity-affect-peri-and-postoperative-morbidity-and-complication-rates-after-minimal-access-spinal-technologies-mast-in-surgery-for-lumbar-degenerative-disc-disease
#14
Wolfgang Senker, Harald Stefanits, Matthias Gmeiner, Wolfgang Trutschnig, Ingo Weinfurter, Andreas Gruber
OBJECTIVE: The impact of obesity on spine surgery has been studied extensively, but just a few investigations have been focused on minimally invasive spinal fusion techniques and complication rates in normal-weight, preobese, or obese patients. Obesity was found to be a risk factor for intraoperative complications. Published data tend to favor minimal access surgery techniques (MAST) for obese patients. In a prospective study, we assessed the perioperative and postoperative complications of MAST in a large population of 187 patients...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29258934/lentivirus-is-an-efficient-and-stable-transduction-vector-for-intervertebral-disc-cells
#15
Yue-Hui Zhang, Yang-Lu Zhao, Bo Li, Jia Song, Jing Zhang, Jiang Shao
OBJECTIVES: To evaluate the transduction efficacy and sustainability of lentiviral vector for intervertebral disc cells, both in vitro and in vivo. METHORDS: Human nuclear pulposus and annulus fibrosus cells isolated from disc tissue of 28 patients during surgical disc procedures were cultured, and subsequently transduced using recombinant lentivirus carrying a gene for enhanced green fluorescent protein (EGFP) at multiplicities of infection (MOI) of 0, 15, 30, 60, 90, and 150...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29258803/antioxidant-functionalized-polymer-capsules-to-prevent-oxidative-stress
#16
Aitor Larrañaga, Isma Liza Mohd Isa, Vaibhav Patil, Sagana Thamboo, Mihai Lomora, Marc A Fernández-Yague, Jose-Ramon Sarasua, Cornelia G Palivan, Abhay Pandit
Polymeric capsules exhibit significant potential for therapeutic applications as microreactors, where the bio-chemical reactions of interest are efficiently performed in a spatial and time defined manner due to the encapsulation of an active biomolecule (e.g., enzyme) and control over the transfer of reagents and products through the capsular membrane. In this work, catalase loaded polymer capsules functionalized with an external layer of tannic acid (TA) are fabricated via a layer-by-layer approach using calcium carbonate as a sacrificial template...
December 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29245217/efficacy-and-safety-of-mobi-c-cervical-artificial-disc-versus-anterior-discectomy-and-fusion-in-patients-with-symptomatic-degenerative-disc-disease-a-meta-analysis
#17
Hui Lu, Lihua Peng
BACKGROUND: Total disc replacement (TDR) using Mobi-C cervical artificial disc might be promising to treat symptomatic degenerative disc disease. However, the results remained controversial. We conducted a systematic review and meta-analysis to compare the efficacy and safety of Mobi-C cervical artificial disc and anterior cervical discectomy and fusion (ACDF) in patients with symptomatic degenerative disc disease. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243996/validation-of-the-visual-analog-scale-in-the-cervical-spine
#18
Anna MacDowall, Martin Skeppholm, Yohan Robinson, Claes Olerud
OBJECTIVE The visual analog scale (VAS) is frequently used to measure treatment outcome in patients with cervical spine disorders. The minimum clinically important difference (MCID) is the smallest change in a score that has clinical importance to the patient. Although it has been established for other medical fields, knowledge of the VAS MCID for the cervical spine is sparse, and it has rarely been considered in relation to measurement noise. The goals in this study were as follows: 1) to validate the VAS-neck and VAS-arm instruments for the cervical spine (e...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29238643/factors-associated-with-clinical-outcomes-after-lumbar-interbody-fusion-with-a-porous-nitinol-implant
#19
Fahad H Abduljabbar, Asim M Makhdom, Mona Rajeh, Alisson R Tales, Jacob Mathew, Jean Ouellet, Michael Weber, Peter Jarzem
Study Design: A retrospective cohort study. Objective: The aim of this study is to assess the association of demographic and perioperative factors with clinical outcomes of lumbar interbody fusion with a porous nitinol (TiNi) implant for degenerative disc disease. Methods: Forty-one patients with degenerative lumbar disease were prospectively followed for a mean of 4.8 years. All patients were instrumented with porous TiNi interbody fusion devices...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237492/pentosan-polysulfate-binds-to-stro-1-mesenchymal-progenitor-cells-is-internalized-and-modifies-gene-expression-a-novel-approach-of-pre-programing-stem-cells-for-therapeutic-application-requiring-their-chondrogenesis
#20
Jiehua Wu, Susan Shimmon, Sharon Paton, Christopher Daly, Tony Goldschlager, Stan Gronthos, Andrew C W Zannettino, Peter Ghosh
BACKGROUND: The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS in mediating these effects remains unresolved. In the present report we address this issue by investigating the binding and uptake of PPS by MPCs and monitoring gene expression and proteoglycan biosynthesis before and after the cells had been exposed to limited concentrations of PPS and then re-established in culture in the absence of the drug (MPC priming)...
December 13, 2017: Stem Cell Research & Therapy
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