keyword
https://read.qxmd.com/read/38524182/characterization-of-a-straboviridae-%C3%A2-phage%C3%A2-vb_abam-shi-and-its-inhibition-effect-on-biofilms-of-acinetobacter-baumannii
#21
JOURNAL ARTICLE
Liming Jiang, Qian Xu, Ying Wu, Xianglian Zhou, Zhu Chen, Qiangming Sun, Jinsheng Wen
Acinetobacter baumannii ( A. baumannii ) is a popular clinical pathogen worldwide. Biofilm-associated antibiotic-resistant A. baumannii infection poses a great threat to human health. Bacteria in biofilms are highly resistant to antibiotics and disinfectants. Furthermore, inhibition or eradication of biofilms in husbandry, the food industry and clinics are almost impossible. Phages can move across the biofilm matrix and promote antibiotic penetration. In the present study, a lytic A. baumannii phage vB_AbaM-SHI, belonging to family Straboviridae , was isolated from sauce chop factory drain outlet in Wuxi, China...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38524181/a-comparative-study-of-genotyping-and-antimicrobial-resistance-between-carbapenem-resistant-klebsiella-pneumoniae-and-acinetobacter-baumannii-isolates-at-a-tertiary-pediatric-hospital-in-china
#22
JOURNAL ARTICLE
Xiaoli Jian, Yunyun Li, Haiping Wang, Cuilian Li, Feng Li, Jue Li, Jing Dong, Tingyi Du, Li Jiang
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolations have rapidly increased in pediatric patients. To investigate a possible health care-associated infections of CRKP in a tertiary pediatric hospital, the circulating clones and carbapenem-resistant pattern between CRKP and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates were compared to classify their epidemiological characteristics. The results will help to identify the epidemic pattern of the CRKP transmission in the hospital...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38522746/antimicrobial-efficacy-of-eravacycline-against-emerging-extensively-drug-resistant-xdr-acinetobacter-baumannii-isolates
#23
JOURNAL ARTICLE
Hitender Gautam, Shahid Raza, Jaya Biswas, Sarita Mohapatra, Seema Sood, Benu Dhawan, Arti Kapil, Bimal K Das
PURPOSE: Drug-resistant Acinetobacter baumannii is an emerging threat. This study has been conducted to observe the efficacy of eravacycline along with the RND-efflux pump system. METHODS: A cross-sectional study was done collecting 48 clinical isolates of Acinetobacter baumannii. MICs of 15 antibiotics were detected along with BMD of tigecycline and eravacycline. PCR products of drug-resistant regulatory genes were sequenced and analyzed. RESULTS: Of the total 48 Isolates, 35 (72...
March 22, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38520916/high-throughput-screening-of-small-molecules-libraries-identified-antibacterials-against-clinically-relevant-multidrug-resistant-a-%C3%A2-baumannii-and-k-%C3%A2-pneumoniae
#24
JOURNAL ARTICLE
Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J V Piddock
BACKGROUND: The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified by the World Health Organization (WHO) as a global health priority. New antibacterials acting through novel mechanisms of action are urgently needed. We aimed to identify new chemical entities (NCEs) with activity against Klebsiella pneumoniae and Acinetobacter baumannii that could be developed into a new treatment for drug-resistant infections...
March 22, 2024: EBioMedicine
https://read.qxmd.com/read/38518683/ineffectiveness-of-colistin-monotherapy-in-treating-carbapenem-resistant-acinetobacter-baumannii-pneumonia-a-retrospective-single-center-cohort-study
#25
JOURNAL ARTICLE
Cheon-Hoo Jeon, Si-Ho Kim, Hyoung-Tae Kim, Kyoung-Jin Park, Yu Mi Wi
BACKGROUND: Acinetobacter baumannii, a common carbapenem-resistant gram-negative bacillus, usually causes nosocomial infections. Colistin has been used for carbapenem-resistant A. baumannii (CRAB) infections; however, only a few studies have evaluated colistin as a treatment option compared to appropriate controls. We investigated the effectiveness of colistin monotherapy in treating CRAB pneumonia compared to those treated without an active drug. METHODS: Adult patients (≥ 18 years) with CRAB isolated from respiratory specimens were screened from September 2017 to August 2022...
March 6, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38517956/supercharged-precision-killers-genetically-engineered-biomimetic-drugs-of-screened-metalloantibiotics-against-acinetobacter-baumanni
#26
JOURNAL ARTICLE
Xianyuan Wei, Bin Xue, Shuangchen Ruan, Jintong Guo, Yujing Huang, Xiaorui Geng, Dan Wang, Cangtao Zhou, Jun Zheng, Zhen Yuan
To eliminate multidrug-resistant bacteria of Acinetobacter baumannii , we screened 1100 Food and Drug Administration-approved small molecule drugs and accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that the prepared Zn(Bq)2 complex showed ultralow minimum inhibitory concentration of ~0.21 micrograms per milliliter with no resistance after 30 passages. We then constructed the nano zeolitic imidazolate framework-8 (ZIF-8) as a drug carrier of Zn(Bq)2 and also incorporated the photosensitizer chlorin e6 (Ce6) to trace and boost the antibacterial effect...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38516533/antibiotic-resistance-of-eskape-group-microorganisms-in-health-institutions-from-hermosillo-and-ciudad-obreg%C3%A3-n-sonora-m%C3%A3-xico
#27
JOURNAL ARTICLE
Maritza Lizeth Álvarez-Ainza, Pedro Alejandro Fong-Coronado, Eduardo Ruiz-Bustos, Lucía Guadalupe Castillón-Campaña, Idania Emedith Quintero-Reyes, Luis Armando Duarte-Zambrano, Enrique Bolado-Martínez
INTRODUCTION: Enterococcus faecium, Staphylococcus aureus , Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter spp. are microorganisms referred as the ESKAPE group pathogens. These microorganisms have generated great concern in health institutions around the world since most of them have resistance to multiple antibiotics and cause most infections associated with healthcare, as well as community infections. The aim of this study was the analysis of antibiotic resistance in microorganisms of the ESKAPE group, recovered from clinical samples in 11 health institutions from Hermosillo and Ciudad Obregón in the State of Sonora, México, during the period from 2019 to 2020...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38516017/a-multiplex-rpa-coupled-with-crispr-cas12a-system-for-rapid-and-cost-effective-identification-of-carbapenem-resistant-acinetobacter-baumannii
#28
JOURNAL ARTICLE
Zihan Zhou, Lina Liang, Chuan Liao, Lele Pan, Chunfang Wang, Jiangmei Ma, Xueli Yi, Meiying Tan, Xuebin Li, Guijiang Wei
BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a severe nosocomial threat, prompting a need for efficient detection methods. Traditional approaches, such as bacterial culture and PCR, are time-consuming and cumbersome. The CRISPR-based gene editing system offered a potential approach for point-of-care testing of CRAB. METHODS: We integrated recombinase polymerase amplification (RPA) and CRISPR-Cas12a system to swiftly diagnose CRAB-associated genes, OXA-51 and OXA-23 ...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38515285/comparative-phenotypic-and-genotypic-analysis-of-community-acquired-and-hospital-acquired-intra-abdominal-infections-among-liver-transplanted-patients
#29
JOURNAL ARTICLE
Arwa R Elmanakhly, Nesreen Safwat, Sally T K Tohamy, Khaled M Elsayed, Heba M ElSherif, Mahitab Elsayed, Reham M El-Tarabili, Majid Alhomrani, Abdulhakeem S Alamri, Mohammed M Ghoneim, Mohammed Abdulrahman Alshahrani, Ahmed Saif, Abdallah Tageldein Mansour, Mahmoud M Bendary
AIM: During liver transplantation, both hospital-acquired (HA) and community-acquired (CA) intra-abdominal infections (IAIs) are involved causing life-threatening diseases. Therefore, comparative studies of aerobic and facultative anaerobic HA-IAIs and CA-IAIs after liver transplantation surgery are necessary. METHODS AND RESULTS: the species of detected isolates (310) from intra-abdominal fluid were identified and classified into HA-IAIs and CA-IAIs. Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii were the most commonly detected species...
March 21, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38511828/restricted-rotational-flexibility-of-the-c5%C3%AE-methyl-substituted-carbapenem-na-1-157-leads-to-potent-inhibition-of-the-ges-5-carbapenemase
#30
JOURNAL ARTICLE
Nichole K Stewart, Marta Toth, Pojun Quan, Michael Beer, John D Buynak, Clyde A Smith, Sergei B Vakulenko
Carbapenem antibiotics are used as a last-resort treatment for infections caused by multidrug-resistant bacteria. The wide spread of carbapenemases in Gram-negative bacteria has severely compromised the utility of these drugs and represents a serious public health threat. To combat carbapenemase-mediated resistance, new antimicrobials and inhibitors of these enzymes are urgently needed. Here, we describe the interaction of the atypically C5α-methyl-substituted carbapenem, NA-1-157, with the GES-5 carbapenemase...
March 21, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38508114/comparative-analysis-of-chlorine-resistant-bacteria-after-chlorination-and-chloramination-in-drinking-water-treatment-plants
#31
JOURNAL ARTICLE
Yijun Wei, Haiyan Wu, Xudong Zhang, Yongbing Liang, Danyang Shi, Lin Wang, Haibei Li, Hongling Yu, Dong Yang, Shuqing Zhou, Tianjiao Chen, Zhongwei Yang, Junwen Li, Min Jin
Chlorine-resistant bacteria (CRB) in drinking water treatment plants (DWTPs) jeopardize water quality and pose a potential risk to human health. However, the specific response of CRB to chlorination and chloramination remains uncharacterized. Therefore, we analyzed 16 S rRNA sequencing data from water samples before and after chlorination and chloramination taken between January and December 2020. Proteobacteria and Firmicutes dominated all finished water samples. After chloramination, Acinetobacter, Pseudomonas, Methylobacterium, Ralstonia, and Sphingomonas were the dominant CRB, whereas Ralstonia, Bacillus, Acinetobacter, Pseudomonas, and Enterococcus were prevalent after chlorination...
March 18, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38507790/co-immobilization-of-ciprofloxacin-and-chlorhexidine-as-a-broad-spectrum-antimicrobial-dual-drug-coating-for-poly-vinyl-chloride-pvc-based-endotracheal-tubes
#32
JOURNAL ARTICLE
Diana Filipa Alves, Maria Olívia Pereira, Susana Patrícia Lopes
The endotracheal tube (ETT) affords support for intubated patients, but the increasing incidence of ventilator-associated pneumonia (VAP) is jeopardizing its application. ETT surfaces promote (poly)microbial colonization and biofilm formation, with a heavy burden for VAP. Devising safe, broad-spectrum antimicrobial materials to tackle the ETT bioburden is needful. Herein, we immobilized ciprofloxacin (CIP) and/or chlorhexidine (CHX), through polydopamine (pDA)-based functionalization, onto poly(vinyl chloride) (PVC) surfaces...
March 20, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38506718/-in-vitro-and-in-silico-assessment-of-anti-biofilm-and-anti-quorum-sensing-properties-of-2-4-di-tert-butylphenol-against-acinetobacter-baumannii
#33
JOURNAL ARTICLE
Nisha Kumari Jha, Venkadesaperumal Gopu, Chandran Sivasankar, Satya Ranjan Singh, Palanisamy Bruntha Devi, Ayaluru Murali, Prathapkumar Halady Shetty
Introduction. Acinetobacter baumannii is a nosocomial pathogen with a high potential to cause food-borne infections. It is designated as a critical pathogen by the World Health Organization due to its multi-drug resistance and mortalities reported. Biofilm governs major virulence factors, which promotes drug resistance in A. baumannii . Thus, a compound with minimum selection pressure on the pathogen can be helpful to breach biofilm-related virulence. Hypothesis/Gap Statement. To identify anti-biofilm and anti-virulent metabolites from extracts of wild Mangifera indica (mango) brine pickle bacteria that diminishes pathogenesis and resistance of A...
March 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38506530/bacterial-hemophilin-homologs-and-their-specific-type-eleven-secretor-proteins-have-conserved-roles-in-heme-capture-and-are-diversifying-as-a-family
#34
JOURNAL ARTICLE
Alex S Grossman, David A Gell, Derek G Wu, Dana L Carper, Robert L Hettich, Heidi Goodrich-Blair
Cellular life relies on enzymes that require metals, which must be acquired from extracellular sources. Bacteria utilize surface and secreted proteins to acquire such valuable nutrients from their environment. These include the cargo proteins of the type eleven secretion system (T11SS), which have been connected to host specificity, metal homeostasis, and nutritional immunity evasion. This Sec-dependent, Gram-negative secretion system is encoded by organisms throughout the phylum Proteobacteria, including human pathogens Neisseria meningitidis, Proteus mirabilis, Acinetobacter baumannii, and Haemophilus influenzae ...
March 20, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38506388/post-trauma-acinetobacter-baumanii-meningitis-treatment-approach
#35
Cem Erdoğan, Zeynep Betul Balcioglu, Isa Seida, Denız Kizilaslan
A. baumannii, which is said to be associated with nosocomial infections is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur in the aftermath of surgery or trauma. Our patient developed complicated A. baumannii meningitis with lateral ventriculitis and a lumbar abscess post surgery after suffering from a fall. The patient was treated with a 21-day regimen of intrathecally administered colistin and polymyxin B. Following this therapeutic period, the patient's condition improved, ultimately leading to successful recovery and subsequent discharge...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/38505565/analysis-of-carbapenem-resistant-acinetobacter-baumannii-carbapenemase-gene-distribution-and-biofilm-formation
#36
JOURNAL ARTICLE
Lin Wang, Qi-Wei Chen, Yan-Chun Qin, Xue-Li Yi, Hong Zeng
OBJECTIVE: In recent years, Acinetobacter baumannii has been appearing in hospitals with high drug resistance and strong vitality, which brings many difficulties to clinical treatment. In this study, 255 strains of A. baumannii were isolated from Youjiang Medical University for Nationalities Affiliated Hospital clinical samples and found to be highly resistant to carbapenems. The drug resistance, biofilm-forming ability, and carbapenase gene distribution of 145 carbapenem-resistant A...
2024: International Journal of Molecular Epidemiology and Genetics
https://read.qxmd.com/read/38504783/hijacking-the-epigenetic-mechanisms-of-a-baumannii
#37
REVIEW
S A Smiline Girija
Epigenetic mechanisms attribute to the resistance and virulence of Acinetobacter baumannii sparking a renewed area of research. Unveiling the targets pertained to the epigenetic modulation in the bacterium would aid in the curbing its complications in various recalcitrant infections. This review thus throws light on the various epigenetic mechanisms exhibited by A. bauamnnii , urging the need to implement epigenetic based novel strategies in precision medicine.
2024: Molecular Biology Research Communications
https://read.qxmd.com/read/38503380/antimicrobial-resistance-landscape-in-a-metropolitan-city-context-using-open-drain-wastewater-based-metagenomic-analysis
#38
JOURNAL ARTICLE
Manas Kumar Madhukar, Nirupama Singh, V Rajesh Iyer, Divya Tej Sowpati, Karthik Bharadwaj Tallapaka, Rakesh Kumar Mishra, Shivranjani Chandrashekhar Moharir
One Health concept recognizes the inextricable interactions of diverse ecosystems and their subsequent effect on human, animal and plant health. Antimicrobial resistance (AMR) is a major One Health concern and is predicted to cause catastrophes if appropriate measures are not implemented. To understand the AMR landscape in a south Indian metropolitan city, metagenomic analysis of open drains was performed. The data suggests that in January 2022, macrolide class of antibiotics contributed the highest resistance of 40...
March 17, 2024: Environmental Research
https://read.qxmd.com/read/38501781/draft-genome-sequence-of-acinetobacter-baumannii-ab10-a-clinical-isolate-from-hospital-university-sains-malaysia-husm-malaysia
#39
JOURNAL ARTICLE
Nik Zakuan Hakim Nik Mohd Nazri, Kirnpal Kaur Banga Singh, Mohamad Izwan Ismail
Acinetobacter baumannii strain Ab10 retrieved in Malaysia in 2017 represents a pathogen carrying multiple antibiotic-resistant genes ( blaOXA-23 , ant(3")-Ila , blaADC-32 , and blaOXA-699 ). We introduce the 3.89 Mbp genome sequence from short-read sequencing (Illumina's NovaSeq6000).
March 19, 2024: Microbiology Resource Announcements
https://read.qxmd.com/read/38501368/in-vitro-activity-of-apramycin-ebl-1003-in-combination-with-colistin-meropenem-minocycline-or-sulbactam-against-xdr-pdr-acinetobacter-baumannii-isolates-from-greece
#40
JOURNAL ARTICLE
I Galani, M Souli, D Katsala, I Karaiskos, H Giamarellou, A Antoniadou
OBJECTIVES: To evaluate the in vitro activity of the combination of apramycin with colistin, meropenem, minocycline or sulbactam, against some well-characterized XDR Acinetobacter baumannii clinical isolates from Greece, to understand how apramycin can be best incorporated into clinical practice and optimize effectiveness. METHODS: In vitro interactions of apramycin (0.5×, 1× and 2× the MIC value) with colistin (2 mg/L), meropenem (30 mg/L), minocycline (3...
March 19, 2024: Journal of Antimicrobial Chemotherapy
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